Review
. 2016 Sep; 20(2):284-8.
doi: 10.4103/0973-029X.185921.

"Slide less pathology": Fairy tale or reality?

M Indu 1 R Rathy 1 M P Binu 2 
Affiliations
  • PMID: 27601824
  •     31 References
  •     7 citations

Abstract

Pathology practice is significantly advanced in various frontiers. Therefore, "slide less digital" pathology will not be a mere imagination in near future. Digitalization of histopathological slides (whole slide imaging [WSI]) is possible with the help of whole slide scanner. The WSI has a positive impact not only in routine practice but also in research field, medical education and bioindustry. Even if digital pathology has definitive advantages, its widespread use is not yet possible. As it is an upcoming technology in our field, this article is aimed to discussessential aspects of WSI.

Keywords: Digital pathology; medical education; telepathology; whole slide imaging.

A relationship between slide quality and image quality in whole slide imaging (WSI).
Yukako Yagi, John R Gilbertson.
Diagn Pathol, 2008 Aug 05; 3 Suppl 1. PMID: 18673500    Free PMC article.
Beyond morphology: whole slide imaging, computer-aided detection, and other techniques.
Michael D Feldman.
Arch Pathol Lab Med, 2008 May 10; 132(5). PMID: 18466019
TuBaFrost 6: virtual microscopy in virtual tumour banking.
I Teodorovic, M Isabelle, +26 authors, P H J Riegman.
Eur J Cancer, 2006 Oct 10; 42(18). PMID: 17027253
Autofocus methods of whole slide imaging systems and the introduction of a second-generation independent dual sensor scanning method.
Michael C Montalto, Richard R McKay, Robert J Filkins.
J Pathol Inform, 2011 Nov 08; 2. PMID: 22059145    Free PMC article.
Virtual slides: application in pulmonary pathology consultations.
Janina Słodkowska, Lech Chyczewski, Michał Wojciechowski.
Folia Histochem Cytobiol, 2008 Feb 26; 46(1). PMID: 18296275
Digital slide and virtual microscopy based routine and telepathology evaluation of routine gastrointestinal biopsy specimens.
B Molnar, L Berczi, +4 authors, Z Tulassay.
J Clin Pathol, 2003 Jun 05; 56(6). PMID: 12783970    Free PMC article.
Multispectral imaging and pathology: seeing and doing more.
Richard M Levenson, Alessandro Fornari, Massimo Loda.
Expert Opin Med Diagn, 2008 Sep 01; 2(9). PMID: 23495926
Utility of whole slide imaging and virtual microscopy in prostate pathology.
Philippe Camparo, Lars Egevad, +12 authors, Murali Varma.
APMIS, 2012 Mar 21; 120(4). PMID: 22429212
Review.
Credentialing preclinical pediatric xenograft models using gene expression and tissue microarray analysis.
Craig C Whiteford, Sven Bilke, +16 authors, Javed Khan.
Cancer Res, 2007 Jan 11; 67(1). PMID: 17210681
Personalized Oncology Suite: integrating next-generation sequencing data and whole-slide bioimages.
Andreas Dander, Matthias Baldauf, +3 authors, Zlatko Trajanoski.
BMC Bioinformatics, 2014 Sep 19; 15. PMID: 25230706    Free PMC article.
Whole slide imaging for educational purposes.
Liron Pantanowitz, Janusz Szymas, Yukako Yagi, David Wilbur.
J Pathol Inform, 2013 Feb 02; 3. PMID: 23372987    Free PMC article.
Evaluation of whole slide image immunohistochemistry interpretation in challenging prostate needle biopsies.
Jeffrey L Fine, Dana M Grzybicki, +8 authors, Drazen M Jukic.
Hum Pathol, 2008 Feb 01; 39(4). PMID: 18234276
Digital pathology: exploring its applications in diagnostic surgical pathology practice.
Ana Richelia Jara-Lazaro, Thomas Paulraj Thamboo, Ming Teh, Puay Hoon Tan.
Pathology, 2010 Sep 22; 42(6). PMID: 20854068
Review.
Reliability of whole slide images as a diagnostic modality for renal allograft biopsies.
Kuang-Yu Jen, Jean L Olson, +3 authors, Zoltan G Laszik.
Hum Pathol, 2012 Dec 04; 44(5). PMID: 23199528
Digital images and the future of digital pathology.
Liron Pantanowitz.
J Pathol Inform, 2010 Oct 06; 1. PMID: 20922032    Free PMC article.
Concordance between telepathologic diagnosis and conventional histopathologic diagnosis: a multiobserver store-and-forward study on 20 skin specimens.
D Piccolo, H Peter Soyer, +18 authors, H Kerl.
Arch Dermatol, 2002 Jan 16; 138(1). PMID: 11790167
Use of the virtual slide and the dynamic real-time telepathology systems for a consultation and the frozen section intra-operative diagnosis in thoracic/pulmonary pathology.
Janina Słodkowska, Juliusz Pankowski, Krystyna Siemiatkowska, Lech Chyczewski.
Folia Histochem Cytobiol, 2009 Jan 01; 47(4). PMID: 20430738
Digital pathology at the crossroads of major health care trends: corporate innovation as an engine for change.
Dirk Soenksen.
Arch Pathol Lab Med, 2009 Apr 28; 133(4). PMID: 19391651
Fine-needle aspiration of follicular adenoma versus parathyroid adenoma: the utility of multispectral imaging in differentiating lesions with subtle cytomorphologic differences.
Ibrahim Mansoor, Carola Zalles, +3 authors, David L Rimm.
Cancer, 2007 Dec 19; 114(1). PMID: 18085636
Open source tools for management and archiving of digital microscopy data to allow integration with patient pathology and treatment information.
Matloob Khushi, Georgina Edwards, +3 authors, Christine L Clarke.
Diagn Pathol, 2013 Feb 14; 8. PMID: 23402499    Free PMC article.
Accuracy of a remote quantitative image analysis in the whole slide images.
Janina Słodkowska, Tomasz Markiewicz, +4 authors, Piotr Murawski.
Diagn Pathol, 2011 Apr 22; 6 Suppl 1. PMID: 21489191    Free PMC article.
Quality evaluation of microscopy and scanned histological images for diagnostic purposes.
R Redondo, G Bueno, +6 authors, J González.
Micron, 2011 Nov 22; 43(2-3). PMID: 22099388
Transition of a dental histology course from light to virtual microscopy.
Frank J Weaker, Damon C Herbert.
J Dent Educ, 2009 Oct 07; 73(10). PMID: 19805786
Validating whole slide imaging for diagnostic purposes in pathology: guideline from the College of American Pathologists Pathology and Laboratory Quality Center.
Liron Pantanowitz, John H Sinard, +8 authors, College of American Pathologists Pathology and Laboratory Quality Center.
Arch Pathol Lab Med, 2013 May 03; 137(12). PMID: 23634907    Free PMC article.
Highly Cited. Review.
Use of mobile high-resolution device for remote frozen section evaluation of whole slide images.
Joel Ramey, Kar Ming Fung, Lewis A Hassell.
J Pathol Inform, 2011 Oct 05; 2. PMID: 21969922    Free PMC article.
Review of the current state of whole slide imaging in pathology.
Liron Pantanowitz, Paul N Valenstein, +5 authors, Terence J Colgan.
J Pathol Inform, 2011 Sep 03; 2. PMID: 21886892    Free PMC article.
Highly Cited.
Five years of experience teaching pathology to dental students using the WebMicroscope.
Janusz Szymas, Mikael Lundin.
Diagn Pathol, 2011 Apr 22; 6 Suppl 1. PMID: 21489183    Free PMC article.
Digital imaging in pathology: whole-slide imaging and beyond.
Farzad Ghaznavi, Andrew Evans, Anant Madabhushi, Michael Feldman.
Annu Rev Pathol, 2012 Nov 20; 8. PMID: 23157334
Review.
Enhanced accuracy and reliability of HER-2/neu immunohistochemical scoring using digital microscopy.
Kenneth Bloom, Douglas Harrington.
Am J Clin Pathol, 2004 May 21; 121(5). PMID: 15151201
Multi-institutional comparison of whole slide digital imaging and optical microscopy for interpretation of hematoxylin-eosin-stained breast tissue sections.
Savitri Krishnamurthy, Kurt Mathews, +12 authors, Kevin Liang.
Arch Pathol Lab Med, 2013 Aug 21; 137(12). PMID: 23947655
Slide2Go: A virtual slide collection for pathology education.
Richard Conran, Paul Fontelo, +2 authors, Elizabeth White.
AMIA Annu Symp Proc, 2008 Aug 13;. PMID: 18694018
Comparison between digital and optical microscopy: Analysis in a mouse gut inflammation model.
Airton Pereira E Silva, Sylvia Maria Nicolau Campos, Isabelle Mazza Guimarães, Gerlinde Agate Platais Brasil Teixeira.
Biomed Rep, 2017 Sep 13; 7(3). PMID: 28894572    Free PMC article.
Development of a reliable and accurate algorithm to quantify the tumor immune stroma (QTiS) across tumor types.
Rainer Christoph Miksch, Jingcheng Hao, +10 authors, Alexandr V Bazhin.
Oncotarget, 2018 Feb 01; 8(70). PMID: 29383131    Free PMC article.
Digital Microscopy, Image Analysis, and Virtual Slide Repository.
Famke Aeffner, Hibret A Adissu, +8 authors, Kristin Wilson.
ILAR J, 2018 Dec 12; 59(1). PMID: 30535284    Free PMC article.
Inter-observer Variability in the Diagnosis of Proliferative Verrucous Leukoplakia: Clinical Implications for Oral and Maxillofacial Surgeon Understanding: A Collaborative Pilot Study.
Jasbir D Upadhyaya, Sarah G Fitzpatrick, +13 authors, Lester D R Thompson.
Head Neck Pathol, 2019 Apr 12; 14(1). PMID: 30972634    Free PMC article.
Whole Slide Imaging (WSI) in Pathology: Current Perspectives and Future Directions.
Neeta Kumar, Ruchika Gupta, Sanjay Gupta.
J Digit Imaging, 2020 May 30; 33(4). PMID: 32468487    Free PMC article.
Review.
Immune contexture analysis in immuno-oncology: applications and challenges of multiplex fluorescent immunohistochemistry.
Reshma Shakya, Tam Hong Nguyen, Nigel Waterhouse, Rajiv Khanna.
Clin Transl Immunology, 2020 Oct 20; 9(10). PMID: 33072322    Free PMC article.
Review.
Alternative Strategy Adopted in Practical Assessment for Pathology Postgraduate Certification Examination Amidst COVID-19 Nationwide Lockdown: An Indian Experience with a Novel Hybrid Method of Assessment.
Shalinee Rao, Nilotpal Chowdhury, +4 authors, Rajesh Kathrotia.
Adv Med Educ Pract, 2021 Jan 16; 12. PMID: 33447127    Free PMC article.