. 2016 Nov;14(3).
doi: 10.1038/nrclinonc.2016.162.

Imaging biomarker roadmap for cancer studies

James P B O'Connor 1 Eric O Aboagye 2 Judith E Adams 3 Hugo J W L Aerts 4 Sally F Barrington 5 Ambros J Beer 6 Ronald Boellaard 7 Sarah E Bohndiek 8 Michael Brady 9 Gina Brown 10 David L Buckley 11 Thomas L Chenevert 12 Laurence P Clarke 13 Sandra Collette 14 Gary J Cook 5 Nandita M deSouza 15 John C Dickson 16 Caroline Dive 17 Jeffrey L Evelhoch 18 Corinne Faivre-Finn 19 Ferdia A Gallagher 8 Fiona J Gilbert 8 Robert J Gillies 20 Vicky Goh 5 John R Griffiths 8 Ashley M Groves 16 Steve Halligan 16 Adrian L Harris 9 David J Hawkes 16 Otto S Hoekstra 21 Erich P Huang 22 Brian F Hutton 16 Edward F Jackson 23 Gordon C Jayson 24 Andrew Jones 25 Dow-Mu Koh 15 Denis Lacombe 26 Philippe Lambin 27 Nathalie Lassau 28 Martin O Leach 15 Ting-Yim Lee 29 Edward L Leen 2 Jason S Lewis 30 Yan Liu 26 Mark F Lythgoe 31 Prakash Manoharan 1 Ross J Maxwell 32 Kenneth A Miles 16 Bruno Morgan 33 Steve Morris 34 Tony Ng 5 Anwar R Padhani 35 Geoff J M Parker 1 Mike Partridge 9 Arvind P Pathak 36 Andrew C Peet 37 Shonit Punwani 16 Andrew R Reynolds 38 Simon P Robinson 15 Lalitha K Shankar 13 Ricky A Sharma 16 Dmitry Soloviev 8 Sigrid Stroobants 39 Daniel C Sullivan 40 Stuart A Taylor 16 Paul S Tofts 41 Gillian M Tozer 42 Marcel van Herk 19 Simon Walker-Samuel 31 James Wason 43 Kaye J Williams 1 Paul Workman 44 Thomas E Yankeelov 45 Kevin M Brindle 8 Lisa M McShane 22 Alan Jackson 1 John C Waterton 1 
  • PMID: 27725679
  •     139 References
  •     220 citations


Imaging biomarkers (IBs) are integral to the routine management of patients with cancer. IBs used daily in oncology include clinical TNM stage, objective response and left ventricular ejection fraction. Other CT, MRI, PET and ultrasonography biomarkers are used extensively in cancer research and drug development. New IBs need to be established either as useful tools for testing research hypotheses in clinical trials and research studies, or as clinical decision-making tools for use in healthcare, by crossing 'translational gaps' through validation and qualification. Important differences exist between IBs and biospecimen-derived biomarkers and, therefore, the development of IBs requires a tailored 'roadmap'. Recognizing this need, Cancer Research UK (CRUK) and the European Organisation for Research and Treatment of Cancer (EORTC) assembled experts to review, debate and summarize the challenges of IB validation and qualification. This consensus group has produced 14 key recommendations for accelerating the clinical translation of IBs, which highlight the role of parallel (rather than sequential) tracks of technical (assay) validation, biological/clinical validation and assessment of cost-effectiveness; the need for IB standardization and accreditation systems; the need to continually revisit IB precision; an alternative framework for biological/clinical validation of IBs; and the essential requirements for multicentre studies to qualify IBs for clinical use.

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Dependence of DCE-MRI biomarker values on analysis algorithm.
Chaan S Ng, Wei Wei, +6 authors, Edward F Jackson.
PLoS One, 2015 Jul 25; 10(7). PMID: 26208254    Free PMC article.
Statistical validation of intermediate endpoints for chronic diseases.
L S Freedman, B I Graubard, A Schatzkin.
Stat Med, 1992 Jan 30; 11(2). PMID: 1579756
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Diffusion-weighted magnetic resonance imaging as a cancer biomarker: consensus and recommendations.
Anwar R Padhani, Guoying Liu, +11 authors, Peter L Choyke.
Neoplasia, 2009 Feb 04; 11(2). PMID: 19186405    Free PMC article.
Highly Cited.
Chemical biology approaches to target validation in cancer.
Julian Blagg, Paul Workman.
Curr Opin Pharmacol, 2014 Sep 02; 17. PMID: 25175311
Dynamic contrast enhanced ultrasound assessment of the vascular effects of novel therapeutics in early stage trials.
Edward Leen, Michalakis Averkiou, +5 authors, Olivier Lucidarme.
Eur Radiol, 2012 Feb 04; 22(7). PMID: 22302501
Prospective study evaluating the relative sensitivity of 18F-NaF PET/CT for detecting skeletal metastases from renal cell carcinoma in comparison to multidetector CT and 99mTc-MDP bone scintigraphy, using an adaptive trial design.
E L Gerety, E M Lawrence, +13 authors, F A Gallagher.
Ann Oncol, 2015 Jul 24; 26(10). PMID: 26202597    Free PMC article.
Role of imaging in the staging and response assessment of lymphoma: consensus of the International Conference on Malignant Lymphomas Imaging Working Group.
Sally F Barrington, N George Mikhaeel, +13 authors, Bruce D Cheson.
J Clin Oncol, 2014 Aug 13; 32(27). PMID: 25113771    Free PMC article.
Highly Cited.
Cost-effectiveness analysis in the assessment of diagnostic imaging technologies.
G Scott Gazelle, Pamela M McMahon, Uwe Siebert, Molly T Beinfeld.
Radiology, 2005 Apr 29; 235(2). PMID: 15858079
Biomarkers in preclinical cancer imaging.
Monique R Bernsen, Klazina Kooiman, +2 authors, Marion de Jong.
Eur J Nucl Med Mol Imaging, 2015 Feb 13; 42(4). PMID: 25673052    Free PMC article.
Publication of tumor marker research results: the necessity for complete and transparent reporting.
Lisa M McShane, Daniel F Hayes.
J Clin Oncol, 2012 Oct 17; 30(34). PMID: 23071235    Free PMC article.
Correlation of computed tomography and positron emission tomography in patients with metastatic gastrointestinal stromal tumor treated at a single institution with imatinib mesylate: proposal of new computed tomography response criteria.
Haesun Choi, Chuslip Charnsangavej, +6 authors, Robert S Benjamin.
J Clin Oncol, 2007 May 02; 25(13). PMID: 17470865
Highly Cited.
Evaluation of the anti-vascular effects of combretastatin in rodent tumours by dynamic contrast enhanced MRI.
Ross J Maxwell, John Wilson, +4 authors, Gillian M Tozer.
NMR Biomed, 2002 Mar 01; 15(2). PMID: 11870904
Meta-analysis of the technical performance of an imaging procedure: guidelines and statistical methodology.
Erich P Huang, Xiao-Feng Wang, +10 authors, Meta-Analysis Working Group.
Stat Methods Med Res, 2014 May 30; 24(1). PMID: 24872353    Free PMC article.
Systematic Review.
Breast cancer therapy-associated cardiovascular disease.
Timothy M Zagar, Daniela M Cardinale, Lawrence B Marks.
Nat Rev Clin Oncol, 2015 Nov 26; 13(3). PMID: 26598943
Minimally invasive pharmacokinetic and pharmacodynamic technologies in hypothesis-testing clinical trials of innovative therapies.
Paul Workman, Eric O Aboagye, +8 authors, Cancer Research UK Pharmacodynamic/Pharmacokinetic Technologies Advisory Committee.
J Natl Cancer Inst, 2006 May 04; 98(9). PMID: 16670384
Strategic paths for biomarker qualification.
Federico M Goodsaid, Felix W Frueh, William Mattes.
Toxicology, 2008 Feb 19; 245(3). PMID: 18280028
Tumorigenicity and genetic profiling of circulating tumor cells in small-cell lung cancer.
Cassandra L Hodgkinson, Christopher J Morrow, +23 authors, Caroline Dive.
Nat Med, 2014 Jun 02; 20(8). PMID: 24880617
Highly Cited.
The APL paradigm and the "co-clinical trial" project.
Caterina Nardella, Andrea Lunardi, +2 authors, Pier Paolo Pandolfi.
Cancer Discov, 2011 Nov 26; 1(2). PMID: 22116793    Free PMC article.
Looking back on the millennium in medicine.
N Engl J Med, 2000 Jan 06; 342(1). PMID: 10620649
Translational Research Working Group developmental pathway for biospecimen-based assessment modalities.
Sudhir Srivastava, Joe W Gray, +4 authors, Translational Research Working Group.
Clin Cancer Res, 2008 Sep 17; 14(18). PMID: 18794074    Free PMC article.
Personalized cancer medicine: molecular diagnostics, predictive biomarkers, and drug resistance.
D Gonzalez de Castro, P A Clarke, B Al-Lazikani, P Workman.
Clin Pharmacol Ther, 2013 Jan 31; 93(3). PMID: 23361103    Free PMC article.
Highly Cited. Review.
Reporting recommendations for tumor marker prognostic studies (REMARK).
Lisa M McShane, Douglas G Altman, +4 authors, Statistics Subcommittee of the NCI-EORTC Working Group on Cancer Diagnostics.
J Natl Cancer Inst, 2005 Aug 18; 97(16). PMID: 16106022
Highly Cited.
Measuring response in a post-RECIST world: from black and white to shades of grey.
Laura C Michaelis, Mark J Ratain.
Nat Rev Cancer, 2006 Apr 25; 6(5). PMID: 16633367
Recommendations on the use of 18F-FDG PET in oncology.
James W Fletcher, Benjamin Djulbegovic, +13 authors, Anthony F Shields.
J Nucl Med, 2008 Feb 22; 49(3). PMID: 18287273
Highly Cited.
The diagnostic accuracy and cost-effectiveness of magnetic resonance spectroscopy and enhanced magnetic resonance imaging techniques in aiding the localisation of prostate abnormalities for biopsy: a systematic review and economic evaluation.
G Mowatt, G Scotland, +9 authors, E Tassie.
Health Technol Assess, 2013 May 24; 17(20). PMID: 23697373    Free PMC article.
Systematic Review.
Bicalutamide 150 mg plus standard care vs standard care alone for early prostate cancer.
David G McLeod, Peter Iversen, +4 authors, Casodex Early Prostate Cancer Trialists' Group.
BJU Int, 2006 Jan 25; 97(2). PMID: 16430622
Quantifying antivascular effects of monoclonal antibodies to vascular endothelial growth factor: insights from imaging.
James P B O'Connor, Richard A D Carano, +26 authors, Gordon C Jayson.
Clin Cancer Res, 2009 Oct 29; 15(21). PMID: 19861458    Free PMC article.
Qualification of imaging biomarkers for oncology drug development.
John C Waterton, Liisa Pylkkanen.
Eur J Cancer, 2012 Jan 10; 48(4). PMID: 22226478
Decoding tumour phenotype by noninvasive imaging using a quantitative radiomics approach.
Hugo J W L Aerts, Emmanuel Rios Velazquez, +15 authors, Philippe Lambin.
Nat Commun, 2014 Jun 04; 5. PMID: 24892406    Free PMC article.
Highly Cited.
2-Deoxy-2-[18F]fluoro-D-glucose positron emission tomography demonstrates target inhibition with the potential to predict anti-tumour activity following treatment with the AKT inhibitor AZD5363.
Juliana Maynard, Sally-Ann Ricketts, +2 authors, Barry R Davies.
Mol Imaging Biol, 2013 Jan 25; 15(4). PMID: 23344784
RECIST - learning from the past to build the future.
Saskia Litière, Sandra Collette, +2 authors, Jan Bogaerts.
Nat Rev Clin Oncol, 2016 Dec 21; 14(3). PMID: 27995946
3D volume reconstruction from serial breast specimen radiographs for mapping between histology and 3D whole specimen imaging.
Thomy Mertzanidou, John H Hipwell, +10 authors, Ritse Mann.
Med Phys, 2017 Jan 09; 44(3). PMID: 28064435    Free PMC article.
Beyond the margins: real-time detection of cancer using targeted fluorophores.
Ray R Zhang, Alexandra B Schroeder, +6 authors, Jamey P Weichert.
Nat Rev Clin Oncol, 2017 Jan 18; 14(6). PMID: 28094261    Free PMC article.
Highly Cited. Review.
Defining Clinical Response Criteria and Early Response Criteria for Precision Oncology: Current State-of-the-Art and Future Perspectives.
Vivek Subbiah, Hubert H Chuang, Dhiraj Gambhire, Kalevi Kairemo.
Diagnostics (Basel), 2017 Feb 18; 7(1). PMID: 28212290    Free PMC article.
Charged-particle therapy in cancer: clinical uses and future perspectives.
Marco Durante, Roberto Orecchia, Jay S Loeffler.
Nat Rev Clin Oncol, 2017 Mar 16; 14(8). PMID: 28290489
Highly Cited. Review.
Molecularly targeted therapies in cancer: a guide for the nuclear medicine physician.
S Lheureux, C Denoyelle, +2 authors, F M Mottaghy.
Eur J Nucl Med Mol Imaging, 2017 Apr 12; 44(Suppl 1). PMID: 28396911    Free PMC article.
Predicting breast cancer response to neoadjuvant chemotherapy using pretreatment diffuse optical spectroscopic texture analysis.
William T Tran, Mehrdad J Gangeh, +12 authors, Gregory J Czarnota.
Br J Cancer, 2017 Apr 19; 116(10). PMID: 28419079    Free PMC article.
The prognostic value of dynamic contrast-enhanced MRI contrast agent transfer constant Ktrans in cervical cancer is explained by plasma flow rather than vessel permeability.
Ben R Dickie, Chris J Rose, +5 authors, Catharine M L West.
Br J Cancer, 2017 Apr 28; 116(11). PMID: 28449009    Free PMC article.
Multiparametric Magnetic Resonance Imaging of the Prostate: Repeatability of Volume and Apparent Diffusion Coefficient Quantification.
Andriy Fedorov, Mark G Vangel, Clare M Tempany, Fiona M Fennessy.
Invest Radiol, 2017 May 04; 52(9). PMID: 28463931    Free PMC article.
Implications of neurovascular uncoupling in functional magnetic resonance imaging (fMRI) of brain tumors.
Rebecca W Pak, Darian H Hadjiabadi, +4 authors, Arvind P Pathak.
J Cereb Blood Flow Metab, 2017 May 12; 37(11). PMID: 28492341    Free PMC article.
Management of unresectable intrahepatic cholangiocarcinoma: how do we decide among the various liver-directed treatments?
Eugene J Koay, Bruno C Odisio, +2 authors, Christopher H Crane.
Hepatobiliary Surg Nutr, 2017 May 16; 6(2). PMID: 28503558    Free PMC article.
Monitoring the Vascular Response and Resistance to Sunitinib in Renal Cell Carcinoma In Vivo with Susceptibility Contrast MRI.
Simon P Robinson, Jessica K R Boult, Naveen S Vasudev, Andrew R Reynolds.
Cancer Res, 2017 Jun 02; 77(15). PMID: 28566330    Free PMC article.
Imaging biomarkers exist and they underpin clinical decision-making.
John C Waterton, Lisa M McShane, James P B O'Connor.
Nat Rev Clin Oncol, 2017 Jun 14; 14(7). PMID: 28607515
Independent imaging biomarkers do not exist.
Harry B Burke.
Nat Rev Clin Oncol, 2017 Jun 14; 14(7). PMID: 28607518
T1 mapping in cardiac MRI.
Dina Radenkovic, Sebastian Weingärtner, +2 authors, Gabriella Captur.
Heart Fail Rev, 2017 Jun 18; 22(4). PMID: 28623475    Free PMC article.
Diffusion magnetic resonance imaging: A molecular imaging tool caught between hope, hype and the real world of "personalized oncology".
Abhishek Mahajan, Sneha S Deshpande, Meenakshi H Thakur.
World J Radiol, 2017 Jul 19; 9(6). PMID: 28717412    Free PMC article.
Defining the biological basis of radiomic phenotypes in lung cancer.
Patrick Grossmann, Olya Stringfield, +8 authors, Hugo Jwl Aerts.
Elife, 2017 Jul 22; 6. PMID: 28731408    Free PMC article.
Highly Cited.
Detecting human melanoma cell re-differentiation following BRAF or heat shock protein 90 inhibition using photoacoustic and magnetic resonance imaging.
Anant Shah, Teresa Delgado-Goni, +6 authors, Mounia Beloueche-Babari.
Sci Rep, 2017 Aug 16; 7(1). PMID: 28811486    Free PMC article.
Oxygen Enhanced Optoacoustic Tomography (OE-OT) Reveals Vascular Dynamics in Murine Models of Prostate Cancer.
Michal R Tomaszewski, Isabel Quiros Gonzalez, +5 authors, Sarah E Bohndiek.
Theranostics, 2017 Aug 22; 7(11). PMID: 28824724    Free PMC article.
Highly Cited.
Data-driven mapping of hypoxia-related tumor heterogeneity using DCE-MRI and OE-MRI.
Adam K Featherstone, James P B O'Connor, +6 authors, Geoff J M Parker.
Magn Reson Med, 2017 Sep 01; 79(4). PMID: 28856728    Free PMC article.
Rethinking the role of clinical imaging.
James Pb O'Connor.
Elife, 2017 Sep 07; 6. PMID: 28876221    Free PMC article.
Targeted gadofullerene for sensitive magnetic resonance imaging and risk-stratification of breast cancer.
Zheng Han, Xiaohui Wu, +3 authors, Zheng-Rong Lu.
Nat Commun, 2017 Sep 28; 8(1). PMID: 28947734    Free PMC article.
Implementing diffusion-weighted MRI for body imaging in prospective multicentre trials: current considerations and future perspectives.
N M deSouza, J M Winfield, +11 authors, Y Liu.
Eur Radiol, 2017 Sep 29; 28(3). PMID: 28956113    Free PMC article.
Standardization of Small Animal Imaging-Current Status and Future Prospects.
Julia G Mannheim, Firat Kara, +7 authors, Marc C Huisman.
Mol Imaging Biol, 2017 Oct 04; 20(5). PMID: 28971332
Radiomics in Brain Tumor: Image Assessment, Quantitative Feature Descriptors, and Machine-Learning Approaches.
M Zhou, J Scott, +10 authors, R Gatenby.
AJNR Am J Neuroradiol, 2017 Oct 07; 39(2). PMID: 28982791    Free PMC article.
Highly Cited. Review.
Rapid volumetric photoacoustic tomographic imaging with a Fabry-Perot ultrasound sensor depicts peripheral arteries and microvascular vasomotor responses to thermal stimuli.
Andrew A Plumb, Nam Trung Huynh, +2 authors, Paul Beard.
Eur Radiol, 2017 Oct 12; 28(3). PMID: 29018924    Free PMC article.
Has molecular imaging delivered to drug development?
Philip S Murphy, Neel Patel, Timothy J McCarthy.
Philos Trans A Math Phys Eng Sci, 2017 Oct 19; 375(2107). PMID: 29038381    Free PMC article.
Characterisation of fibrosis in chemically-induced rat mammary carcinomas using multi-modal endogenous contrast MRI on a 1.5T clinical platform.
Neil P Jerome, Jessica K R Boult, +6 authors, Simon P Robinson.
Eur Radiol, 2017 Oct 19; 28(4). PMID: 29038934    Free PMC article.
Quantitative magnetic resonance imaging biomarkers in oncological clinical trials: Current techniques and standardization challenges.
Jie Deng, Yi Wang.
Chronic Dis Transl Med, 2017 Oct 25; 3(1). PMID: 29063052    Free PMC article.
UK quantitative WB-DWI technical workgroup: consensus meeting recommendations on optimisation, quality control, processing and analysis of quantitative whole-body diffusion-weighted imaging for cancer.
Anna Barnes, Roberto Alonzi, +22 authors, Shonit Punwani.
Br J Radiol, 2017 Oct 28; 91(1081). PMID: 29076749    Free PMC article.
Data Science in Radiology: A Path Forward.
Hugo J W L Aerts.
Clin Cancer Res, 2017 Nov 04; 24(3). PMID: 29097379    Free PMC article.
Molecular Imaging to Predict Response to Targeted Therapies in Renal Cell Carcinoma.
Ingrid Leguerney, Ludovic de Rochefort, +8 authors, Nathalie Lassau.
Contrast Media Mol Imaging, 2017 Nov 04; 2017. PMID: 29097936    Free PMC article.
A biomimetic tumor tissue phantom for validating diffusion-weighted MRI measurements.
Damien J McHugh, Feng-Lei Zhou, +4 authors, Geoffrey J M Parker.
Magn Reson Med, 2017 Nov 21; 80(1). PMID: 29154442    Free PMC article.
Towards enhanced PET quantification in clinical oncology.
Habib Zaidi, Nicolas Karakatsanis.
Br J Radiol, 2017 Nov 23; 91(1081). PMID: 29164924    Free PMC article.
Non-Invasive Prostate Cancer Characterization with Diffusion-Weighted MRI: Insight from In silico Studies of a Transgenic Mouse Model.
Deborah K Hill, Andreas Heindl, +10 authors, Matthew D Blackledge.
Front Oncol, 2017 Dec 19; 7. PMID: 29250485    Free PMC article.
A Bayesian framework for performance assessment and comparison of imaging biomarker quantification methods.
Brian J Smith, Reinhard R Beichel.
Stat Methods Med Res, 2017 Dec 23; 28(4). PMID: 29271301    Free PMC article.
Cancer imaging phenomics toolkit: quantitative imaging analytics for precision diagnostics and predictive modeling of clinical outcome.
Christos Davatzikos, Saima Rathore, +22 authors, Despina Kontos.
J Med Imaging (Bellingham), 2018 Jan 18; 5(1). PMID: 29340286    Free PMC article.
Highly Cited.
Fc-Mediated Anomalous Biodistribution of Therapeutic Antibodies in Immunodeficient Mouse Models.
Sai Kiran Sharma, Andrew Chow, +8 authors, Jason S Lewis.
Cancer Res, 2018 Jan 25; 78(7). PMID: 29363548    Free PMC article.
Highly Cited.
The prognostic and predictive value of vascular response parameters measured by dynamic contrast-enhanced-CT, -MRI and -US in patients with metastatic renal cell carcinoma receiving sunitinib.
John M Hudson, Colleen Bailey, +6 authors, Georg A Bjarnason.
Eur Radiol, 2018 Feb 01; 28(6). PMID: 29383520
Radiomics and radiogenomics for precision radiotherapy.
Jia Wu, Khin Khin Tha, Lei Xing, Ruijiang Li.
J Radiat Res, 2018 Feb 01; 59(suppl_1). PMID: 29385618    Free PMC article.
Review of quantitative multiscale imaging of breast cancer.
Michael A Pinkert, Lonie R Salkowski, +3 authors, Kevin W Eliceiri.
J Med Imaging (Bellingham), 2018 Feb 03; 5(1). PMID: 29392158    Free PMC article.
Challenges and Promises of PET Radiomics.
Gary J R Cook, Gurdip Azad, +2 authors, Vicky Goh.
Int J Radiat Oncol Biol Phys, 2018 Feb 06; 102(4). PMID: 29395627    Free PMC article.
How to perform Contrast-Enhanced Ultrasound (CEUS).
Christoph F Dietrich, Michalakis Averkiou, +40 authors, Sue Westerway.
Ultrasound Int Open, 2018 Feb 10; 4(1). PMID: 29423461    Free PMC article.
Highly Cited. Review.
A methodology review on the incremental prognostic value of computed tomography biomarkers in addition to Framingham risk score in predicting cardiovascular disease: the use of association, discrimination and reclassification.
Chun Lap Pang, Nicola Pilkington, +3 authors, Chris Hyde.
BMC Cardiovasc Disord, 2018 Feb 23; 18(1). PMID: 29466951    Free PMC article.
Systematic Review.
Multiparametric PET/MR imaging biomarkers are associated with overall survival in patients with pancreatic cancer.
Bang-Bin Chen, Yu-Wen Tien, +8 authors, Tiffany Ting-Fang Shih.
Eur J Nucl Med Mol Imaging, 2018 Feb 25; 45(7). PMID: 29476229
Integration of pharmacology, molecular pathology, and population data science to support precision gastrointestinal oncology.
Shuji Ogino, Iny Jhun, +9 authors, Andrew T Chan.
NPJ Precis Oncol, 2017 Jan 01; 1. PMID: 29552640    Free PMC article.
Quantitative perfusion imaging of neoplastic liver lesions: A multi-institution study.
Shivani Pahwa, Hao Liu, +14 authors, Vikas Gulani.
Sci Rep, 2018 Mar 23; 8(1). PMID: 29563601    Free PMC article.
Multiregional radiomics features from multiparametric MRI for prediction of MGMT methylation status in glioblastoma multiforme: A multicentre study.
Zhi-Cheng Li, Hongmin Bai, +6 authors, Hairong Zheng.
Eur Radiol, 2018 Mar 23; 28(9). PMID: 29564594
Optoacoustics delineates murine breast cancer models displaying angiogenesis and vascular mimicry.
Isabel Quiros-Gonzalez, Michal R Tomaszewski, +6 authors, Sarah E Bohndiek.
Br J Cancer, 2018 Mar 27; 118(8). PMID: 29576623    Free PMC article.
Data Analysis Strategies in Medical Imaging.
Chintan Parmar, Joseph D Barry, +2 authors, Hugo J W L Aerts.
Clin Cancer Res, 2018 Mar 28; 24(15). PMID: 29581134    Free PMC article.
Magnetic resonance imaging in active surveillance-a modern approach.
Francesco Giganti, Caroline M Moore.
Transl Androl Urol, 2018 Mar 30; 7(1). PMID: 29594026    Free PMC article.
Molecular Imaging in Oncology Using Positron Emission Tomography.
Thorsten Derlin, Viktor Grünwald, +2 authors, Tobias L Ross.
Dtsch Arztebl Int, 2018 Apr 03; 115(11). PMID: 29607803    Free PMC article.
The future of image-guided radiotherapy-is image everything?
David J Noble, Neil G Burnet.
Br J Radiol, 2018 Apr 05; 91(1087). PMID: 29616822    Free PMC article.
Reproducibility and Repeatability of Semiquantitative 18F-Fluorodihydrotestosterone Uptake Metrics in Castration-Resistant Prostate Cancer Metastases: A Prospective Multicenter Study.
Hebert Alberto Vargas, Gem M Kramer, +24 authors, Michael J Morris.
J Nucl Med, 2018 Apr 08; 59(10). PMID: 29626121    Free PMC article.
The search for drug-targetable diagnostic, prognostic and predictive biomarkers in chronic graft-versus-host disease.
Hong-Gang Ren, Djamilatou Adom, Sophie Paczesny.
Expert Rev Clin Immunol, 2018 Apr 10; 14(5). PMID: 29629613    Free PMC article.
Motion model ultrasound localization microscopy for preclinical and clinical multiparametric tumor characterization.
Tatjana Opacic, Stefanie Dencks, +8 authors, Fabian Kiessling.
Nat Commun, 2018 Apr 20; 9(1). PMID: 29670096    Free PMC article.
Circulating Tumor Cell Analysis in Preclinical Mouse Models of Metastasis.
Jenna Kitz, Lori E Lowes, David Goodale, Alison L Allan.
Diagnostics (Basel), 2018 May 02; 8(2). PMID: 29710776    Free PMC article.
Imaging biomarkers from multiparametric magnetic resonance imaging are associated with survival outcomes in patients with brain metastases from breast cancer.
Bang-Bin Chen, Yen-Shen Lu, +5 authors, Tiffany Ting-Fang Shih.
Eur Radiol, 2018 May 18; 28(11). PMID: 29770848
Artificial intelligence in radiology.
Ahmed Hosny, Chintan Parmar, +2 authors, Hugo J W L Aerts.
Nat Rev Cancer, 2018 May 20; 18(8). PMID: 29777175    Free PMC article.
Highly Cited. Review.
Utilizing Peptide Ligand GPCRs to Image and Treat Pancreatic Cancer.
Gail L Matters, John F Harms.
Biomedicines, 2018 Jun 06; 6(2). PMID: 29865257    Free PMC article.
Magnetic Resonance Fingerprinting-An Overview.
Ananya Panda, Bhairav B Mehta, +5 authors, Vikas Gulani.
Curr Opin Biomed Eng, 2018 Jun 06; 3. PMID: 29868647    Free PMC article.
Role of DCE-MR in predicting breast cancer subtypes.
Marco Macchini, Martina Ponziani, +4 authors, Gian Marco Giuseppetti.
Radiol Med, 2018 Jun 06; 123(10). PMID: 29869226
Mapping Hypoxia in Renal Carcinoma with Oxygen-enhanced MRI: Comparison with Intrinsic Susceptibility MRI and Pathology.
Ross A Little, Yann Jamin, +17 authors, James P B O'Connor.
Radiology, 2018 Jun 06; 288(3). PMID: 29869970    Free PMC article.
Brain tumors disrupt the resting-state connectome.
Darian H Hadjiabadi, Leland Pung, +6 authors, Arvind P Pathak.
Neuroimage Clin, 2018 Jun 08; 18. PMID: 29876248    Free PMC article.
What is the prognostic impact of FDG PET in locally advanced head and neck squamous cell carcinoma treated with concomitant chemo-radiotherapy? A systematic review and meta-analysis.
Pierluigi Bonomo, A Merlotti, +8 authors, S Caini.
Eur J Nucl Med Mol Imaging, 2018 Jun 28; 45(12). PMID: 29948105    Free PMC article.
Simultaneous Estimation of Bias and Resolution in PET Images With a Long-Lived "Pocket" Phantom System.
Paul E Kinahan, Darrin W Byrd, +6 authors, Ricardo S Avila.
Tomography, 2018 Jul 10; 4(1). PMID: 29984312    Free PMC article.
Future directions for therapeutic strategies in post-ischaemic vascularization: a position paper from European Society of Cardiology Working Group on Atherosclerosis and Vascular Biology.
Andrea Caporali, Magnus Bäck, +13 authors, Paul C Evans.
Cardiovasc Res, 2018 Jul 18; 114(11). PMID: 30016405    Free PMC article.
Survival Prediction in High-grade Osteosarcoma Using Radiomics of Diagnostic Computed Tomography.
Yan Wu, Lei Xu, +13 authors, Zhaoming Ye.
EBioMedicine, 2018 Jul 22; 34. PMID: 30026116    Free PMC article.
The Potential of In Vivo Imaging for Optimization of Molecular and Cellular Anti-cancer Immunotherapies.
Gilbert O Fruhwirth, Manfred Kneilling, +3 authors, Erik H J G Aarntzen.
Mol Imaging Biol, 2018 Jul 22; 20(5). PMID: 30030697    Free PMC article.
Evaluating Imaging Biomarkers of Acquired Resistance to Targeted EGFR Therapy in Xenograft Models of Human Head and Neck Squamous Cell Carcinoma.
Lauren C J Baker, Arti Sikka, +10 authors, Simon P Robinson.
Front Oncol, 2018 Aug 08; 8. PMID: 30083516    Free PMC article.
Multicentre analysis of PET SUV using vendor-neutral software: the Japanese Harmonization Technology (J-Hart) study.
Yuji Tsutsui, Hiromitsu Daisaki, +10 authors, J-Hart study group.
EJNMMI Res, 2018 Aug 22; 8(1). PMID: 30128776    Free PMC article.
Challenges and Technological Trends Toward Improved Medical Imaging-based Predictive Data-mining.
Assaf Zaritsky.
EBioMedicine, 2018 Aug 23; 35. PMID: 30131304    Free PMC article.
Magnetic resonance imaging biomarkers for chronic kidney disease: a position paper from the European Cooperation in Science and Technology Action PARENCHIMA.
Nicholas M Selby, Peter J Blankestijn, +31 authors, Steven Sourbron.
Nephrol Dial Transplant, 2018 Aug 24; 33(suppl_2). PMID: 30137584    Free PMC article.
Optical in vivo imaging detection of preclinical models of gut tumors through the expression of integrin αVβ3.
Giulia Marelli, Roberta Avigni, +4 authors, Marco Erreni.
Oncotarget, 2018 Aug 25; 9(59). PMID: 30140377    Free PMC article.
Machine Learning Applications in Head and Neck Radiation Oncology: Lessons From Open-Source Radiomics Challenges.
Hesham Elhalawani, Timothy A Lin, +45 authors, Clifton D Fuller.
Front Oncol, 2018 Sep 04; 8. PMID: 30175071    Free PMC article.
Radiomics signature of computed tomography imaging for prediction of survival and chemotherapeutic benefits in gastric cancer.
Yuming Jiang, Chuanli Chen, +10 authors, Guoxin Li.
EBioMedicine, 2018 Sep 19; 36. PMID: 30224313    Free PMC article.
Translational molecular imaging in exocrine pancreatic cancer.
Bart Cornelissen, James C Knight, +8 authors, Fijs W B van Leeuwen.
Eur J Nucl Med Mol Imaging, 2018 Sep 19; 45(13). PMID: 30225616    Free PMC article.
Standardization of [F-18]FDG PET/CT for response evaluation by the Radiologic Society of North America-Quantitative Imaging Biomarker Alliance (RSNA-QIBA) profile: preliminary results from the Japan-QIBA (J-QIBA) activities for Asian international multicenter phase II trial.
Hyeyeol Bae, Junichi Tsuchiya, +5 authors, Ukihide Tateishi.
Jpn J Radiol, 2018 Sep 27; 36(11). PMID: 30251115
Non-invasive imaging of disrupted protein homeostasis induced by proteasome inhibitor treatment using chemical exchange saturation transfer MRI.
Yanan Zhu, Rajiv Ramasawmy, +8 authors, Simon Walker-Samuel.
Sci Rep, 2018 Oct 12; 8(1). PMID: 30305717    Free PMC article.
A radiogenomic dataset of non-small cell lung cancer.
Shaimaa Bakr, Olivier Gevaert, +14 authors, Sandy Napel.
Sci Data, 2018 Oct 17; 5. PMID: 30325352    Free PMC article.
Predicting the response to neoadjuvant therapy for early-stage breast cancer: tumor-, blood-, and imaging-related biomarkers.
Wenyong Tan, Ming Yang, +2 authors, Weixi Shen.
Cancer Manag Res, 2018 Oct 24; 10. PMID: 30349367    Free PMC article.
Repeatability of dynamic contrast enhanced vp parameter in healthy subjects and patients with brain tumors.
Moran Artzi, Gilad Liberman, +3 authors, Dafna Ben Bashat.
J Neurooncol, 2018 Nov 06; 140(3). PMID: 30392091
Metabolic Volumetric Parameters in 11C-Choline PET/MR Are Superior PET Imaging Biomarkers for Primary High-Risk Prostate Cancer.
Jing-Ren Tseng, Lan-Yan Yang, +5 authors, Li-Jen Wang.
Contrast Media Mol Imaging, 2018 Dec 12; 2018. PMID: 30532664    Free PMC article.
Decision Support Systems in Oncology.
Seán Walsh, Evelyn E C de Jong, +13 authors, Philippe Lambin.
JCO Clin Cancer Inform, 2019 Feb 08; 3. PMID: 30730766    Free PMC article.
Translating preclinical MRI methods to clinical oncology.
David A Hormuth, Anna G Sorace, +11 authors, Thomas E Yankeelov.
J Magn Reson Imaging, 2019 Mar 30; 50(5). PMID: 30925001    Free PMC article.
Radiomics in peritumoral non-enhancing regions: fractional anisotropy and cerebral blood volume improve prediction of local progression and overall survival in patients with glioblastoma.
Jung Youn Kim, Min Jae Yoon, +3 authors, Ho Sung Kim.
Neuroradiology, 2019 Jul 11; 61(11). PMID: 31289886
AI-based applications in hybrid imaging: how to build smart and truly multi-parametric decision models for radiomics.
Isabella Castiglioni, Francesca Gallivanone, +5 authors, Marco Salvatore.
Eur J Nucl Med Mol Imaging, 2019 Jul 12; 46(13). PMID: 31292700
Impact of Molybdenum Compounds as Anticancer Agents.
Ayodele T Odularu, Peter A Ajibade, Johannes Z Mbese.
Bioinorg Chem Appl, 2019 Oct 05; 2019. PMID: 31582964    Free PMC article.
Imaging of T-cells and their responses during anti-cancer immunotherapy.
Massis Krekorian, Gilbert O Fruhwirth, +4 authors, Erik H J G Aarntzen.
Theranostics, 2019 Oct 28; 9(25). PMID: 31656546    Free PMC article.
A Scoping Review of Non-invasive Imaging Modalities in Dermatological Disease: Potential Novel Biomarkers in Hidradenitis Suppurativa.
David Grand, Kristina Navrazhina, John W Frew.
Front Med (Lausanne), 2019 Nov 30; 6. PMID: 31781567    Free PMC article.
VERDICT MRI for Prostate Cancer: Intracellular Volume Fraction versus Apparent Diffusion Coefficient.
Edward W Johnston, Elisenda Bonet-Carne, +24 authors, Shonit Punwani.
Radiology, 2019 Apr 03; 291(2). PMID: 30938627    Free PMC article.
Machine learning and glioma imaging biomarkers.
T C Booth, M Williams, +3 authors, H Shuaib.
Clin Radiol, 2019 Aug 03; 75(1). PMID: 31371027    Free PMC article.
REVIEW: MR elastography of brain tumors.
Adomas Bunevicius, Katharina Schregel, +2 authors, Samuel Patz.
Neuroimage Clin, 2019 Dec 07; 25. PMID: 31809993    Free PMC article.
Harmonizing brain magnetic resonance imaging methods for vascular contributions to neurodegeneration.
Eric E Smith, Geert Jan Biessels, +46 authors, Joanna M Wardlaw.
Alzheimers Dement (Amst), 2019 Mar 13; 11. PMID: 30859119    Free PMC article.
Prostate cancer androgen receptor splice variant 7 biomarker study - a multicentre randomised feasibility trial of biomarker-guided personalised treatment in patients with advanced prostate cancer (the VARIANT trial) study protocol.
Emma Clark, Miranda Morton, +14 authors, Rakesh Heer.
BMJ Open, 2019 Dec 21; 9(12). PMID: 31857319    Free PMC article.
Quality of science and reporting of radiomics in oncologic studies: room for improvement according to radiomics quality score and TRIPOD statement.
Ji Eun Park, Donghyun Kim, +5 authors, Jeong Hoon Kim.
Eur Radiol, 2019 Jul 28; 30(1). PMID: 31350588
Vascular contributions to cognitive impairment and dementia: Research consortia that focus on etiology and treatable targets to lessen the burden of dementia worldwide.
Jordan T Gladman, Roderick A Corriveau, +5 authors, Geert Jan Biessels.
Alzheimers Dement (N Y), 2020 Jan 11; 5. PMID: 31921967    Free PMC article.
A systematic review reporting quality of radiomics research in neuro-oncology: toward clinical utility and quality improvement using high-dimensional imaging features.
Ji Eun Park, Ho Sung Kim, +4 authors, Jeong Hoon Kim.
BMC Cancer, 2020 Jan 12; 20(1). PMID: 31924170    Free PMC article.
Systematic Review.
Molecular imaging biomarkers for immune checkpoint inhibitor therapy.
Pim P van de Donk, Laura Kist de Ruijter, +6 authors, Elisabeth Ge de Vries.
Theranostics, 2020 Feb 12; 10(4). PMID: 32042331    Free PMC article.
Development of an embedded multimodality imaging platform for onco-pharmacology using a smart anticancer prodrug as an example.
Florian Raes, Serigne Moussa Badiane, +3 authors, Alain Le Pape.
Sci Rep, 2020 Feb 16; 10(1). PMID: 32060400    Free PMC article.
Imaging biomarkers in oncology: Basics and application to MRI.
Isabel Dregely, Davide Prezzi, +3 authors, Vicky Goh.
J Magn Reson Imaging, 2018 Jul 04; 48(1). PMID: 29969192    Free PMC article.
Repeatability of Multiparametric Prostate MRI Radiomics Features.
Michael Schwier, Joost van Griethuysen, +7 authors, Andriy Fedorov.
Sci Rep, 2019 Jul 03; 9(1). PMID: 31263116    Free PMC article.
Highly Cited.
Cousins at work: How combining medical with optical imaging enhances in vivo cell tracking.
Alessia Volpe, Ewelina Kurtys, Gilbert O Fruhwirth.
Int J Biochem Cell Biol, 2018 Jul 01; 102. PMID: 29960079    Free PMC article.
Histogram Analysis Parameters Derived from Conventional T1- and T2-Weighted Images Can Predict Different Histopathological Features Including Expression of Ki67, EGFR, VEGF, HIF-1α, and p53 and Cell Count in Head and Neck Squamous Cell Carcinoma.
Hans Jonas Meyer, Leonard Leifels, +2 authors, Alexey Surov.
Mol Imaging Biol, 2018 Oct 05; 21(4). PMID: 30284155
Towards a 'resolution limit' for DW-MRI tumor microstructural models: A simulation study investigating the feasibility of distinguishing between microstructural changes.
Damien J McHugh, Penny L Hubbard Cristinacce, Josephine H Naish, Geoffrey J M Parker.
Magn Reson Med, 2018 Oct 20; 81(4). PMID: 30338871    Free PMC article.
Triply Loaded Nitroxide Brush-Arm Star Polymers Enable Metal-Free Millimetric Tumor Detection by Magnetic Resonance Imaging.
Hung V-T Nguyen, Alexandre Detappe, +12 authors, Jeremiah A Johnson.
ACS Nano, 2018 Nov 06; 12(11). PMID: 30387988    Free PMC article.
Ultrasensitive detection of miRNA with an antimonene-based surface plasmon resonance sensor.
Tianyu Xue, Weiyuan Liang, +12 authors, Qiaoliang Bao.
Nat Commun, 2019 Jan 04; 10(1). PMID: 30604756    Free PMC article.
Radiomic signature of 18F fluorodeoxyglucose PET/CT for prediction of gastric cancer survival and chemotherapeutic benefits.
Yuming Jiang, Qingyu Yuan, +13 authors, Guoxin Li.
Theranostics, 2019 Jan 08; 8(21). PMID: 30613271    Free PMC article.
NCTN Assessment on Current Applications of Radiomics in Oncology.
Ke Nie, Hania Al-Hallaq, +15 authors, Issam El Naqa.
Int J Radiat Oncol Biol Phys, 2019 Feb 04; 104(2). PMID: 30711529    Free PMC article.
The use of digital pathology and image analysis in clinical trials.
Robert Pell, Karin Oien, +6 authors, UK National Cancer Research Institute (NCRI) Cellular-Molecular Pathology (CM-Path) quality assurance working group.
J Pathol Clin Res, 2019 Feb 16; 5(2). PMID: 30767396    Free PMC article.
Hybrid PET/MR Kernelised Expectation Maximisation Reconstruction for Improved Image-Derived Estimation of the Input Function from the Aorta of Rabbits.
Daniel Deidda, Nicolas A Karakatsanis, +6 authors, Charalampos Tsoumpas.
Contrast Media Mol Imaging, 2019 Feb 26; 2019. PMID: 30800014    Free PMC article.
Multiparameter MRI Predictors of Long-Term Survival in Glioblastoma Multiforme.
Olya Stringfield, John A Arrington, +9 authors, Natarajan Raghunand.
Tomography, 2019 Mar 12; 5(1). PMID: 30854451    Free PMC article.
The Applications of Radiomics in Precision Diagnosis and Treatment of Oncology: Opportunities and Challenges.
Zhenyu Liu, Shuo Wang, +8 authors, Jie Tian.
Theranostics, 2019 Mar 15; 9(5). PMID: 30867832    Free PMC article.
Highly Cited. Review.
MRI Imaging of the Hemodynamic Vasculature of Neuroblastoma Predicts Response to Antiangiogenic Treatment.
Konstantinos Zormpas-Petridis, Neil P Jerome, +18 authors, Yann Jamin.
Cancer Res, 2019 Mar 17; 79(11). PMID: 30877107    Free PMC article.
How rapid advances in imaging are defining the future of precision radiation oncology.
Laura Beaton, Steve Bandula, Mark N Gaze, Ricky A Sharma.
Br J Cancer, 2019 Mar 27; 120(8). PMID: 30911090    Free PMC article.
FDG PET based prediction of response in head and neck cancer treatment: Assessment of new quantitative imaging features.
Reinhard R Beichel, Ethan J Ulrich, +6 authors, John M Buatti.
PLoS One, 2019 Apr 20; 14(4). PMID: 31002689    Free PMC article.
Longitudinal radiomics of cone-beam CT images from non-small cell lung cancer patients: Evaluation of the added prognostic value for overall survival and locoregional recurrence.
Janna E van Timmeren, Wouter van Elmpt, +11 authors, Philippe Lambin.
Radiother Oncol, 2019 Apr 25; 136. PMID: 31015133    Free PMC article.
Quantifying blood-brain barrier leakage in small vessel disease: Review and consensus recommendations.
Michael J Thrippleton, Walter H Backes, +9 authors, Joanna M Wardlaw.
Alzheimers Dement, 2019 Apr 30; 15(6). PMID: 31031101    Free PMC article.
Highly Cited. Review.
Biobanking in health care: evolution and future directions.
Luigi Coppola, Alessandra Cianflone, +7 authors, Marco Salvatore.
J Transl Med, 2019 May 24; 17(1). PMID: 31118074    Free PMC article.
Photoacoustic imaging as a tool to probe the tumour microenvironment.
Emma Brown, Joanna Brunker, Sarah E Bohndiek.
Dis Model Mech, 2019 Jul 25; 12(7). PMID: 31337635    Free PMC article.
A Novel Comprehensive Clinical Stratification Model to Refine Prognosis of Glioblastoma Patients Undergoing Surgical Resection.
Tamara Ius, Fabrizio Pignotti, +14 authors, Giovanni Sabatino.
Cancers (Basel), 2020 Feb 13; 12(2). PMID: 32046132    Free PMC article.
Gastric cancer and imaging biomarkers: Part 1 - a critical review of DW-MRI and CE-MDCT findings.
Francesco Giganti, Lei Tang, Hideo Baba.
Eur Radiol, 2018 Oct 04; 29(4). PMID: 30280246    Free PMC article.
Development and validation of a prognostic index for efficacy evaluation and prognosis of first-line chemotherapy in stage III-IV lung squamous cell carcinoma.
Jiangdian Song, Jie Tian, +10 authors, Mingfang Zhao.
Eur Radiol, 2019 Jan 16; 29(5). PMID: 30643941    Free PMC article.
Image-based biomarkers for solid tumor quantification.
Peter Savadjiev, Jaron Chong, +4 authors, Benoit Gallix.
Eur Radiol, 2019 Apr 10; 29(10). PMID: 30963275
OncoMX: A Knowledgebase for Exploring Cancer Biomarkers in the Context of Related Cancer and Healthy Data.
Hayley M Dingerdissen, Frederic Bastian, +12 authors, Raja Mazumder.
JCO Clin Cancer Inform, 2020 Mar 07; 4. PMID: 32142370    Free PMC article.
Imaging tumour hypoxia with oxygen-enhanced MRI and BOLD MRI.
James P B O'Connor, Simon P Robinson, John C Waterton.
Br J Radiol, 2018 Oct 03; 92(1095). PMID: 30272998    Free PMC article.
PRIMAGE project: predictive in silico multiscale analytics to support childhood cancer personalised evaluation empowered by imaging biomarkers.
Luis Martí-Bonmatí, Ángel Alberich-Bayarri, +31 authors, Emanuele Neri.
Eur Radiol Exp, 2020 Apr 05; 4(1). PMID: 32246291    Free PMC article.
Methodological consensus on clinical proton MRS of the brain: Review and recommendations.
Martin Wilson, Ovidiu Andronesi, +46 authors, Franklyn A Howe.
Magn Reson Med, 2019 Mar 29; 82(2). PMID: 30919510    Free PMC article.
Highly Cited. Review.
Quantitative imaging biomarkers alliance (QIBA) recommendations for improved precision of DWI and DCE-MRI derived biomarkers in multicenter oncology trials.
Amita Shukla-Dave, Nancy A Obuchowski, +14 authors, Edward F Jackson.
J Magn Reson Imaging, 2018 Nov 20; 49(7). PMID: 30451345    Free PMC article.
Highly Cited. Review.
How Non-invasive in vivo Cell Tracking Supports the Development and Translation of Cancer Immunotherapies.
Madeleine Iafrate, Gilbert O Fruhwirth.
Front Physiol, 2020 Apr 25; 11. PMID: 32327996    Free PMC article.
Current and Future Imaging Methods for Evaluating Response to Immunotherapy in Neuro-Oncology.
Benjamin B Kasten, Neha Udayakumar, +7 authors, Jason M Warram.
Theranostics, 2019 Aug 15; 9(17). PMID: 31410203    Free PMC article.
The Image Biomarker Standardization Initiative: Standardized Quantitative Radiomics for High-Throughput Image-based Phenotyping.
Alex Zwanenburg, Martin Vallières, +60 authors, Steffen Löck.
Radiology, 2020 Mar 11; 295(2). PMID: 32154773    Free PMC article.
Highly Cited.
How to develop a meaningful radiomic signature for clinical use in oncologic patients.
Nikolaos Papanikolaou, Celso Matos, Dow Mu Koh.
Cancer Imaging, 2020 May 03; 20(1). PMID: 32357923    Free PMC article.
Medical physics challenges in clinical MR-guided radiotherapy.
Christopher Kurz, Giulia Buizza, +8 authors, Marco Riboldi.
Radiat Oncol, 2020 May 07; 15(1). PMID: 32370788    Free PMC article.
Report on computational assessment of Tumor Infiltrating Lymphocytes from the International Immuno-Oncology Biomarker Working Group.
Mohamed Amgad, Elisabeth Specht Stovgaard, +66 authors, International Immuno-Oncology Biomarker Working Group.
NPJ Breast Cancer, 2020 May 16; 6. PMID: 32411818    Free PMC article.
Osteoarthritis of the Temporomandibular Joint can be diagnosed earlier using biomarkers and machine learning.
Jonas Bianchi, Antônio Carlos de Oliveira Ruellas, +15 authors, Lucia Helena Soares Cevidanes.
Sci Rep, 2020 May 18; 10(1). PMID: 32415284    Free PMC article.
Repeatability of Quantitative Imaging Features in Prostate Magnetic Resonance Imaging.
Hong Lu, Nestor A Parra, +8 authors, Yoganand Balagurunathan.
Front Oncol, 2020 May 28; 10. PMID: 32457827    Free PMC article.
Tissue-specific and interpretable sub-segmentation of whole tumour burden on CT images by unsupervised fuzzy clustering.
Leonardo Rundo, Lucian Beer, +6 authors, Ramona Woitek.
Comput Biol Med, 2020 May 19; 120. PMID: 32421652    Free PMC article.
Radiomics of computed tomography and magnetic resonance imaging in renal cell carcinoma-a systematic review and meta-analysis.
Stephan Ursprung, Lucian Beer, +4 authors, Evis Sala.
Eur Radiol, 2020 Feb 16; 30(6). PMID: 32060715    Free PMC article.
Systematic Review.
Quantitative Imaging Informatics for Cancer Research.
Andrey Fedorov, Reinhard Beichel, +18 authors, Ron Kikinis.
JCO Clin Cancer Inform, 2020 May 12; 4. PMID: 32392097    Free PMC article.
CT-based radiomics scores predict response to neoadjuvant chemotherapy and survival in patients with gastric cancer.
Kai-Yu Sun, Hang-Tong Hu, +12 authors, Jian-Bo Xu.
BMC Cancer, 2020 May 27; 20(1). PMID: 32450841    Free PMC article.
Machine-learning based MRI radiomics models for early detection of radiation-induced brain injury in nasopharyngeal carcinoma.
Bin Zhang, Zhouyang Lian, +8 authors, Shuixing Zhang.
BMC Cancer, 2020 Jun 04; 20(1). PMID: 32487085    Free PMC article.
Reproducibility and Generalizability in Radiomics Modeling: Possible Strategies in Radiologic and Statistical Perspectives.
Ji Eun Park, Seo Young Park, Hwa Jung Kim, Ho Sung Kim.
Korean J Radiol, 2019 Jul 05; 20(7). PMID: 31270976    Free PMC article.
Highly Cited. Review.
Noninvasive diffusion magnetic resonance imaging of brain tumour cell size for the early detection of therapeutic response.
Thomas A Roberts, Harpreet Hyare, +15 authors, Simon Walker-Samuel.
Sci Rep, 2020 Jun 10; 10(1). PMID: 32514049    Free PMC article.
Quantitative imaging for radiotherapy purposes.
Oliver J Gurney-Champion, Faisal Mahmood, +6 authors, Kathrine R Redalen.
Radiother Oncol, 2020 Mar 03; 146. PMID: 32114268    Free PMC article.
Multisite Technical and Clinical Performance Evaluation of Quantitative Imaging Biomarkers from 3D FDG PET Segmentations of Head and Neck Cancer Images.
Brian J Smith, John M Buatti, +17 authors, Reinhard R Beichel.
Tomography, 2020 Jun 18; 6(2). PMID: 32548282    Free PMC article.
Diffusion model comparison identifies distinct tumor sub-regions and tracks treatment response.
Damien J McHugh, Grazyna Lipowska-Bhalla, +9 authors, Geoffrey J M Parker.
Magn Reson Med, 2020 Feb 15; 84(3). PMID: 32057115    Free PMC article.
Measuring diffusion exchange across the cell membrane with DEXSY (Diffusion Exchange Spectroscopy).
James O Breen-Norris, Bernard Siow, +8 authors, Simon Walker-Samuel.
Magn Reson Med, 2020 Feb 16; 84(3). PMID: 32060975    Free PMC article.
Cyclo-oxygenase-2 expression is associated with mean standardised uptake value on 18F-Fluorodeoxyglucose positron emission tomography in oesophageal adenocarcinoma.
Kieran G Foley, Adam Christian, +4 authors, Ashley Roberts.
Br J Radiol, 2019 Apr 16; 92(1099). PMID: 30982333    Free PMC article.
Combining imaging- and gene-based hypoxia biomarkers in cervical cancer improves prediction of chemoradiotherapy failure independent of intratumour heterogeneity.
Christina S Fjeldbo, Tord Hompland, +5 authors, Heidi Lyng.
EBioMedicine, 2020 Jun 25; 57. PMID: 32580139    Free PMC article.
Application of PET Tracers in Molecular Imaging for Breast Cancer.
Jorianne Boers, Erik F J de Vries, +2 authors, Carolina P Schröder.
Curr Oncol Rep, 2020 Jul 07; 22(8). PMID: 32627087    Free PMC article.
Single-layer boron-doped graphene quantum dots for contrast-enhanced in vivo T1-weighted MRI.
Hui Wang, Richard Revia, +3 authors, Miqin Zhang.
Nanoscale Horiz, 2020 Mar 03; 5(3). PMID: 32118222    Free PMC article.
Radiomics as a personalized medicine tool in lung cancer: Separating the hope from the hype.
Isabella Fornacon-Wood, Corinne Faivre-Finn, James P B O'Connor, Gareth J Price.
Lung Cancer, 2020 Jun 21; 146. PMID: 32563015    Free PMC article.
A new prognostic hypoxia biomarker consisting of imaging and gene-based data.
Elisa Thomas, Mechthild Krause.
EBioMedicine, 2020 Aug 03; 58. PMID: 32739865    Free PMC article.
Initial clinical experience of Stereotactic Body Radiation Therapy (SBRT) for liver metastases, primary liver malignancy, and pancreatic cancer with 4D-MRI based online adaptation and real-time MRI monitoring using a 1.5 Tesla MR-Linac.
William A Hall, Michael W Straza, +7 authors, Eric S Paulson.
PLoS One, 2020 Aug 09; 15(8). PMID: 32764748    Free PMC article.
Pathological validation and prognostic potential of quantitative MRI in the characterization of pancreas cancer: preliminary experience.
Remy Klaassen, Anne Steins, +15 authors, Hanneke W M van Laarhoven.
Mol Oncol, 2020 Apr 15; 14(9). PMID: 32285559    Free PMC article.
Immunohistochemistry and Radiomic Features for Survival Prediction in Small Cell Lung Cancer.
Eleni Gkika, Matthias Benndorf, +13 authors, Gian Kayser.
Front Oncol, 2020 Sep 10; 10. PMID: 32903606    Free PMC article.
National Trends in Oncologic Diagnostic Imaging.
Andrew B Rosenkrantz, Laura Chaves Cerdas, +3 authors, Hedvig Hricak.
J Am Coll Radiol, 2020 Jul 09; 17(9). PMID: 32640248    Free PMC article.
COVID-19 Biomarkers in research: Extension of the OncoMX cancer biomarker data model to capture biomarker data from other diseases.
N Gogate, D Lyman, +4 authors, R Mazumder.
bioRxiv, 2020 Sep 17;. PMID: 32935101    Free PMC article.
Radiomics Nomogram for Prediction of Peritoneal Metastasis in Patients With Gastric Cancer.
Weicai Huang, Kangneng Zhou, +13 authors, Guoxin Li.
Front Oncol, 2020 Sep 26; 10. PMID: 32974149    Free PMC article.
Emerging Functional Imaging Biomarkers of Tumour Responses to Radiotherapy.
Alan Campbell, Laura M Davis, Sophie K Wilkinson, Richard L Hesketh.
Cancers (Basel), 2019 Jan 27; 11(2). PMID: 30678055    Free PMC article.
How clinical imaging can assess cancer biology.
Roberto García-Figueiras, Sandra Baleato-González, +7 authors, Herbert Alberto Vargas.
Insights Imaging, 2019 Mar 05; 10(1). PMID: 30830470    Free PMC article.
Quantitative SPECT: the time is now.
John Dickson, James Ross, Stefan Vöö.
EJNMMI Phys, 2019 Mar 05; 6(1). PMID: 30830530    Free PMC article.
The surgical perspective in precision treatment of diffuse gliomas.
Niklas Thon, Joerg-Christian Tonn, Friedrich-Wilhelm Kreth.
Onco Targets Ther, 2019 Mar 14; 12. PMID: 30863116    Free PMC article.
Reproducibility and non-redundancy of radiomic features extracted from arterial phase CT scans in hepatocellular carcinoma patients: impact of tumor segmentation variability.
Qingtao Qiu, Jinghao Duan, +6 authors, Yong Yin.
Quant Imaging Med Surg, 2019 Apr 30; 9(3). PMID: 31032192    Free PMC article.
Radiomics Signature on Computed Tomography Imaging: Association With Lymph Node Metastasis in Patients With Gastric Cancer.
Yuming Jiang, Wei Wang, +12 authors, Guoxin Li.
Front Oncol, 2019 May 21; 9. PMID: 31106158    Free PMC article.
Validated imaging biomarkers as decision-making tools in clinical trials and routine practice: current status and recommendations from the EIBALL* subcommittee of the European Society of Radiology (ESR).
Nandita M deSouza, Eric Achten, +18 authors, European Society of Radiology.
Insights Imaging, 2019 Aug 31; 10(1). PMID: 31468205    Free PMC article.
A Good Practice-Compliant Clinical Trial Imaging Management System for Multicenter Clinical Trials: Development and Validation Study.
Youngbin Shin, Kyung Won Kim, +7 authors, Seong Ho Park.
JMIR Med Inform, 2019 Sep 01; 7(3). PMID: 31471962    Free PMC article.
Clinical Value of Serum S100A8/A9 and CA15-3 in the Diagnosis of Breast Cancer.
Samaneh Khorrami, Masoumeh Tavakoli, Elahe Safari.
Iran J Pathol, 2019 Sep 19; 14(2). PMID: 31528166    Free PMC article.
Reliability and prognostic value of radiomic features are highly dependent on choice of feature extraction platform.
Isabella Fornacon-Wood, Hitesh Mistry, +5 authors, James P B O'Connor.
Eur Radiol, 2020 Jun 03; 30(11). PMID: 32483644    Free PMC article.
First clinical study of a pegylated diabody 124I-labeled PEG-AVP0458 in patients with tumor-associated glycoprotein 72 positive cancers.
Andrew M Scott, Timothy Akhurst, +19 authors, Peter J Hudson.
Theranostics, 2020 Oct 15; 10(25). PMID: 33052222    Free PMC article.
Imaging for Response Assessment in Cancer Clinical Trials.
Anna G Sorace, Asser A Elkassem, +10 authors, Andrew D Smith.
Semin Nucl Med, 2020 Oct 17; 50(6). PMID: 33059819    Free PMC article.
The Unique Pharmacometrics of Small Molecule Therapeutic Drug Tracer Imaging for Clinical Oncology.
Mark P S Dunphy, Nagavarakishore Pillarsetty.
Cancers (Basel), 2020 Sep 26; 12(9). PMID: 32971780    Free PMC article.
Application of Radiomics for the Prediction of Radiation-Induced Toxicity in the IMRT Era: Current State-of-the-Art.
Isacco Desideri, Mauro Loi, +3 authors, Pierluigi Bonomo.
Front Oncol, 2020 Oct 30; 10. PMID: 33117669    Free PMC article.
Pharmacokinetic Principles and Their Application to Central Nervous System Tumors.
Joelle P Straehla, Katherine E Warren.
Pharmaceutics, 2020 Oct 11; 12(10). PMID: 33036139    Free PMC article.
Development and validation of radiomics model built by incorporating machine learning for identifying liver fibrosis and early-stage cirrhosis.
Qing-Tao Qiu, Jing Zhang, +3 authors, Yong Yin.
Chin Med J (Engl), 2020 Oct 04; 133(22). PMID: 33009025    Free PMC article.
Diffusion-weighted imaging of the breast: current status as an imaging biomarker and future role.
Julia Camps-Herrero.
BJR Open, 2019 Mar 08; 1(1). PMID: 33178933    Free PMC article.
Imaging biomarkers in upper gastrointestinal cancers.
Michela Gabelloni, Lorenzo Faggioni, Emanuele Neri.
BJR Open, 2019 Jun 24; 1(1). PMID: 33178936    Free PMC article.
Shortwave infrared emitting multicolored nanoprobes for biomarker-specific cancer imaging in vivo.
Harini Kantamneni, Shravani Barkund, +9 authors, Prabhas V Moghe.
BMC Cancer, 2020 Nov 12; 20(1). PMID: 33172421    Free PMC article.
Use of machine learning in geriatric clinical care for chronic diseases: a systematic literature review.
Avishek Choudhury, Emily Renjilian, Onur Asan.
JAMIA Open, 2020 Nov 21; 3(3). PMID: 33215079    Free PMC article.
Multiparametric Magnetic Resonance Imaging for Bladder Cancer: Development of VI-RADS (Vesical Imaging-Reporting And Data System).
Valeria Panebianco, Yoshifumi Narumi, +15 authors, James W F Catto.
Eur Urol, 2018 May 15; 74(3). PMID: 29755006    Free PMC article.
A risk-based approach to identifying oligometastatic disease on imaging.
Nandita M deSouza, Clare M Tempany.
Int J Cancer, 2018 Aug 12; 144(3). PMID: 30098215    Free PMC article.
Repeatability and Reproducibility of Radiomic Features: A Systematic Review.
Alberto Traverso, Leonard Wee, Andre Dekker, Robert Gillies.
Int J Radiat Oncol Biol Phys, 2018 Sep 02; 102(4). PMID: 30170872    Free PMC article.
Highly Cited. Systematic Review.
Radiomics with artificial intelligence for precision medicine in radiation therapy.
Hidetaka Arimura, Mazen Soufi, +2 authors, Masahiro Yamada.
J Radiat Res, 2018 Sep 25; 60(1). PMID: 30247662    Free PMC article.
A comparison of pseudo-continuous arterial spin labelling and dynamic susceptibility contrast MRI with and without contrast agent leakage correction in paediatric brain tumours.
Jan Novak, Stephanie Barbara Withey, +3 authors, Andrew C Peet.
Br J Radiol, 2018 Oct 26; 92(1094). PMID: 30358415    Free PMC article.
Clinical significance of the EMD/mesorectum ratio of T3 mid-low rectal cancer: A retrospective observational study.
Chaoyang Gu, Xuyang Yang, +8 authors, Ziqiang Wang.
Medicine (Baltimore), 2018 Dec 05; 97(48). PMID: 30508974    Free PMC article.
Repeatability and reproducibility of longitudinal relaxation rate in 12 small-animal MRI systems.
John C Waterton, Catherine D G Hines, +24 authors, Gunnar Schütz.
Magn Reson Imaging, 2019 Mar 16; 59. PMID: 30872166    Free PMC article.
Magnetic resonance imaging in categorization of ovarian epithelial cancer and survival analysis with focus on apparent diffusion coefficient value: correlation with Ki-67 expression and serum cancer antigen-125 level.
Guofu Zhang, Weigen Yao, +6 authors, He Zhang.
J Ovarian Res, 2019 Jun 28; 12(1). PMID: 31242916    Free PMC article.
Three-dimensional (3D) magnetic resonance volume assessment and loco-regional failure in anal cancer: early evaluation case-control study.
Hema Sekhar, Rohit Kochhar, +7 authors, Andrew G Renehan.
BMC Cancer, 2020 Dec 02; 20(1). PMID: 33256671    Free PMC article.
Radiology in the era of value-based healthcare: a multi-society expert statement from the ACR, CAR, ESR, IS3R, RANZCR, and RSNA.
Adrian P Brady, Jaqueline A Bello, +11 authors, James A Brink.
Insights Imaging, 2020 Dec 22; 11(1). PMID: 33345287    Free PMC article.
Generating patient-specific virtual tumor populations with reaction-diffusion models and molecular imaging data.
Nick Henscheid.
Math Biosci Eng, 2021 Jan 01; 17(6). PMID: 33378865    Free PMC article.
Hypoxia gene expression signatures as predictive biomarkers for personalising radiotherapy.
Lingjian Yang, Catharine Ml West.
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Targeting the vasculature of tumours: combining VEGF pathway inhibitors with radiotherapy.
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Laure Fournier, Lena Costaridou, +31 authors, European Society Of Radiology.
Eur Radiol, 2021 Jan 26;. PMID: 33492473
Radiomics and Dosiomics for Predicting Local Control after Carbon-Ion Radiotherapy in Skull-Base Chordoma.
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Classification of paediatric brain tumours by diffusion weighted imaging and machine learning.
Jan Novak, Niloufar Zarinabad, +18 authors, Andrew Peet.
Sci Rep, 2021 Feb 06; 11(1). PMID: 33542327    Free PMC article.
The Value of Early Tumor Size Response to Chemotherapy in Pediatric Rhabdomyosarcoma.
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A systematic review of radiomics in osteosarcoma: utilizing radiomics quality score as a tool promoting clinical translation.
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Br J Dermatol, 2020 Jul 01; 184(4). PMID: 32602132    Free PMC article.
A Position Statement on the Utility of Interval Imaging in Standard of Care Brain Tumour Management: Defining the Evidence Gap and Opportunities for Future Research.
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Front Oncol, 2021 Feb 27; 11. PMID: 33634034    Free PMC article.
Nanomaterials for Antiangiogenic Therapies for Cancer: A Promising Tool for Personalized Medicine.
Hashem O Alsaab, Alanoud S Al-Hibs, +5 authors, Yusuf S Althobaiti.
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Identifying Robust Radiomics Features for Lung Cancer by Using In-Vivo and Phantom Lung Lesions.
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Parametric Response Mapping of FLAIR MRI Provides an Early Indication of Progression Risk in Glioblastoma.
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Contrast-Enhanced Ultrasound (CEUS) in Non-Traumatic Abdominal Emergencies.
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Ultrasound Int Open, 2021 Mar 18; 6(3). PMID: 33728394    Free PMC article.
Decoding and Systematization of Medical Imaging Features of Multiple Human Malignancies.
Lu Wang, Zhaoyu Liu, +8 authors, Jiangdian Song.
Radiol Imaging Cancer, 2021 Mar 30; 2(5). PMID: 33778732    Free PMC article.
MR-Guided Radiotherapy for Head and Neck Cancer: Current Developments, Perspectives, and Challenges.
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Mass spectrometry imaging to detect lipid biomarkers and disease signatures in cancer.
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Impact of CT convolution kernel on robustness of radiomic features for different lung diseases and tissue types.
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Repeatability and reproducibility of apparent diffusion coefficient and fat fraction measurement of focal myeloma lesions on whole body magnetic resonance imaging.
Tara Barwick, Matthew Orton, +5 authors, Christina Messiou.
Br J Radiol, 2021 Mar 19; 94(1120). PMID: 33733812    Free PMC article.
Radiomic analysis of magnetic resonance fingerprinting in adult brain tumors.
Sara Dastmalchian, Ozden Kilinc, +9 authors, Chaitra Badve.
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Predicting treatment response from longitudinal images using multi-task deep learning.
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