. 2016 Oct; 40(12):e94-e102.
doi: 10.1097/PAS.0000000000000749.

The Surveillance, Epidemiology, and End Results (SEER) Program and Pathology: Toward Strengthening the Critical Relationship

Máire A Duggan 1 William F Anderson  Sean Altekruse  Lynne Penberthy  Mark E Sherman  
  • PMID: 27740970
  •     40 References
  •     83 citations


The Surveillance, Epidemiology, and End Results (SEER) program of the National Cancer Institute collects data on cancer diagnoses, treatment, and survival for approximately 30% of the United States (US) population. To reflect advances in research and oncology practice, approaches to cancer control are evolving from simply enumerating the development of cancers by organ site in populations to including monitoring of cancer occurrence by histopathologic and molecular subtype, as defined by driver mutations and other alterations. SEER is an important population-based resource for understanding the implications of pathology diagnoses across demographic groups, geographic regions, and time and provides unique insights into the practice of oncology in the US that are not attainable from other sources. It provides incidence, survival, and mortality data for histopathologic cancer subtypes, and data by molecular subtyping are expanding. The program is developing systems to capture additional biomarker data, results from special populations, and expand biospecimen banking to enable cutting-edge cancer research and oncology practice. Pathology has always been central and critical to the effectiveness of SEER, and strengthening this relationship in this modern era of cancer diagnosis could be mutually beneficial. Achieving this goal requires close interactions between pathologists and the SEER program. This review provides a brief overview of SEER, focuses on facets relevant to pathology practice and research, and highlights the opportunities and challenges for pathologists to benefit from and enhance the value of SEER data.

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Cancer Epidemiol Biomarkers Prev, 2020 Dec 18; 30(1). PMID: 33328255    Free PMC article.
Clinicopathological characteristics and prognostic factors of pulmonary sarcomatoid carcinoma: a large population analysis.
Jin Gang, Qiao Yan, +2 authors, Lujun Zhao.
Ann Transl Med, 2021 Feb 12; 9(2). PMID: 33569423    Free PMC article.
Mixture Cure Models in Oncology: A Tutorial and Practical Guidance.
Federico Felizzi, Noman Paracha, Johannes Pöhlmann, Joshua Ray.
Pharmacoecon Open, 2021 Feb 28; 5(2). PMID: 33638063
The Value of Real-World Data in Understanding Prostate Cancer Risk and Improving Clinical Care: Examples from Swedish Registries.
Kerri Beckmann, Hans Garmo, Ingela Franck Lissbrant, Pär Stattin.
Cancers (Basel), 2021 Mar 07; 13(4). PMID: 33669624    Free PMC article.
Dynamic changes in marital status and survival in women with breast cancer: a population-based study.
Wu Ding, Guodong Ruan, +3 authors, Zhian Li.
Sci Rep, 2021 Mar 10; 11(1). PMID: 33686220    Free PMC article.
Racial Disparities in the Incidence and Survival of Spinal Meningioma.
Mahmoud Dibas, Ahmad Mamoun Rajab, +4 authors, Nazmus Saquib.
Asian J Neurosurg, 2021 Mar 13; 15(4). PMID: 33708657    Free PMC article.
Survival analysis of second primary malignancies after cervical cancer using a competing risk model: implications for prevention and surveillance.
Runmei Li, Yue Zhang, +3 authors, Zhenyu Wu.
Ann Transl Med, 2021 Mar 13; 9(3). PMID: 33708866    Free PMC article.
Lung Cancer Attributed Mortality Among 316,336 Early Stage Breast Cancer Cases Treated by Radiotherapy and/or Chemotherapy, 2000-2015: Evidence From the SEER Database.
Semaw Ferede Abera, Rafael T Mikolajczyk, +6 authors, Daniel Medenwald.
Front Oncol, 2021 Mar 16; 10. PMID: 33718108    Free PMC article.
Construction of a clinical survival prognostic model for middle-aged and elderly patients with stage III rectal adenocarcinoma.
Hao Liu, Yu Li, +4 authors, Jian Zhang.
World J Clin Cases, 2021 Mar 18; 9(7). PMID: 33728300    Free PMC article.
Assessing spatial confounding in cancer disease mapping using R.
Douglas R M Azevedo, Dipankar Bandyopadhyay, +2 authors, Dina Garcia.
Cancer Rep (Hoboken), 2020 Jul 29; 3(4). PMID: 32721138    Free PMC article.
Travel, Treatment Choice, and Survival Among Breast Cancer Patients: A Population-Based Analysis.
Colleen F Longacre, Hannah T Neprash, +2 authors, Beth A Virnig.
Womens Health Rep (New Rochelle), 2021 Apr 01; 2(1). PMID: 33786524    Free PMC article.
Disruption of Endoplasmic Reticulum and ROS Production in Human Ovarian Cancer by Campesterol.
Hyocheol Bae, Sunwoo Park, +2 authors, Whasun Lim.
Antioxidants (Basel), 2021 Apr 04; 10(3). PMID: 33802602    Free PMC article.
Contemporary North-American population-based validation of the International Germ Cell Consensus Classification for metastatic germ cell tumors of the testis.
Elio Mazzone, Sophie Knipper, +9 authors, Pierre I Karakiewicz.
World J Urol, 2019 Aug 30; 38(6). PMID: 31463562
Failure of an Ancient Breast Implant Can Lead to Significant Morbidity.
Ali K Mohammed, Sherif Monib.
Cureus, 2021 Apr 10; 13(3). PMID: 33833920    Free PMC article.
Breast Cancer in the Presence of Failed Saline Breast Implants.
Sherif Monib, Simon Thomson.
Cureus, 2021 May 04; 13(3). PMID: 33936908    Free PMC article.
The role of sex genotype in paediatric CNS tumour incidence and survival.
Wai Cheong Soon, Edward Goacher, +5 authors, Ryan Koshy Mathew.
Childs Nerv Syst, 2021 May 06;. PMID: 33950317
Geospatial analysis, web-based mapping and determinants of prostate cancer incidence in Georgia counties: evidence from the 2012-2016 SEER data.
Justice Moses K Aheto, Ovie A Utuama, Getachew A Dagne.
BMC Cancer, 2021 May 08; 21(1). PMID: 33957887    Free PMC article.
Development of a nomogram model to predict survival outcomes in patients with primary hepatic neuroendocrine tumors based on SEER database.
Ziteng Zhang, Xin Zhao, +4 authors, Guobao Li.
BMC Cancer, 2021 May 20; 21(1). PMID: 34006241    Free PMC article.