Transcriptional Landscape of Human Tissue Lymphocytes Unveils Uniqueness of Tumor-Infiltrating T Regulatory Cells

Marco De Simone ¹, Alberto Arrigoni ¹, Grazisa Rossetti ¹, Paola Gruarin ¹, Valeria Ranzani ¹, Claudia Politano ¹, Raoul J P Bonnal ¹, Elena Provasi ¹, Maria Lucia Sarnicola ¹, Ilaria Panzeri ¹, Monica Moro ¹, Mariacristina Crosti ¹, Saveria Mazzara ¹, Valentina Vaira ², Silvano Bosari ³, Alessandro Palleschi ⁴, Luigi Santambrogio ⁵, Giorgio Bovo ⁶, Nicola Zucchini ⁶, Mauro Totis ⁷, Luca Gianotti ⁸, Giancarlo Cesana ⁹, Roberto A Perego ⁹, Nirvana Maroni ¹⁰, Andrea Pisani Ceretti ¹⁰, Enrico Opocher ¹¹, Raffaele De Francesco ¹, Jens Geginat ¹, Hendrik G Stunnenberg ¹², Sergio Abrignani ¹³, Massimiliano Pagani ¹⁴

Affiliations

¹ Istituto Nazionale Genetica Molecolare INGM 'Romeo ed Enrica Invernizzi,' Milan 20122, Italy.
² Istituto Nazionale Genetica Molecolare INGM 'Romeo ed Enrica Invernizzi,' Milan 20122, Italy; Division of Pathology, IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan 20122, Italy; Department of Pathophysiology and Organ Transplantation, Università degli Studi di Milano, Milano 20122, Italy.
³ Division of Pathology, IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan 20122, Italy; Department of Pathophysiology and Organ Transplantation, Università degli Studi di Milano, Milano 20122, Italy.
⁴ Division of Thoracic Surgery, IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan 20122, Italy.
⁵ Division of Thoracic Surgery, IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan 20122, Italy; Department of Pathophysiology and Organ Transplantation, Università degli Studi di Milano, Milano 20122, Italy.
⁶ Department of Pathology, San Gerardo Hospital, Monza 20900, Italy.
⁷ Department of Surgery, San Gerardo Hospital, Monza 20900, Italy.
⁸ Department of Surgery, San Gerardo Hospital, Monza 20900, Italy; School of Medicine and Surgery, Milano-Bicocca University, Monza 20900 Italy.
⁹ School of Medicine and Surgery, Milano-Bicocca University, Monza 20900 Italy.
¹⁰ UO Chirurgia Epatobiliopancreatica e Digestiva Ospedale San Paolo, Milan 20142, Italy.
¹¹ UO Chirurgia Epatobiliopancreatica e Digestiva Ospedale San Paolo, Milan 20142, Italy; Department of Health Sciences, Università degli Studi di Milano, Milano 20122, Italy.
¹² Department of Molecular Biology, Faculty of Science, Radboud University, Nijmegen, The Netherlands.
¹³ Istituto Nazionale Genetica Molecolare INGM 'Romeo ed Enrica Invernizzi,' Milan 20122, Italy; Department of Clinical Sciences and Community Health, Università degli Studi di Milano, Milano 20122, Italy. Electronic address: abrignani@ingm.org.
¹⁴ Istituto Nazionale Genetica Molecolare INGM 'Romeo ed Enrica Invernizzi,' Milan 20122, Italy; Department of Medical Biotechnology and Translational Medicine, Università degli Studi di Milano, Milano 20129, Italy. Electronic address: pagani@ingm.org.

PMID: 27851914
56 References
219 citations

Abstract

Tumor-infiltrating regulatory T lymphocytes (Treg) can suppress effector T cells specific for tumor antigens. Deeper molecular definitions of tumor-infiltrating-lymphocytes could thus offer therapeutic opportunities. Transcriptomes of T helper 1 (Th1), Th17, and Treg cells infiltrating colorectal or non-small-cell lung cancers were compared to transcriptomes of the same subsets from normal tissues and validated at the single-cell level. We found that tumor-infiltrating Treg cells were highly suppressive, upregulated several immune-checkpoints, and expressed on the cell surfaces specific signature molecules such as interleukin-1 receptor 2 (IL1R2), programmed death (PD)-1 Ligand1, PD-1 Ligand2, and CCR8 chemokine, which were not previously described on Treg cells. Remarkably, high expression in whole-tumor samples of Treg cell signature genes, such as LAYN, MAGEH1, or CCR8, correlated with poor prognosis. Our findings provide insights into the molecular identity and functions of human tumor-infiltrating Treg cells and define potential targets for tumor immunotherapy.

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Cancer Immunotherapies Targeting Tumor-Associated Regulatory T Cells. Xiaoxu Ge, Yamei Zhao, +2 authors, Chao Chen, Jian Wang, Lifeng Sun. less Onco Targets Ther, 2020 Jan 31; 12. PMID: 31997881 Free PMC article. Review.
Targeting ST2 expressing activated regulatory T cells in Kras-mutant lung cancer. Byung-Seok Kim, Jelita Clinton, Qing Wang, Seon Hee Chang. Oncoimmunology, 2020 Feb 01; 9(1). PMID: 32002289 Free PMC article.
Understanding the glioblastoma immune microenvironment as basis for the development of new immunotherapeutic strategies. Ana Rita Pombo Antunes, Isabelle Scheyltjens, +3 authors, Jo A Van Ginderachter. less Elife, 2020 Feb 06; 9. PMID: 32014107 Free PMC article. Review.
Cancer immunosurveillance by CD8 T cells. José C Crispin, George C Tsokos. F1000Res, 2020 Feb 25; 9. PMID: 32089832 Free PMC article. Review.
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A novel signature derived from immunoregulatory and hypoxia genes predicts prognosis in liver and five other cancers. Wai Hoong Chang, Donall Forde, Alvina G Lai. J Transl Med, 2019 Jan 11; 17(1). PMID: 30626396 Free PMC article.
Correlate tumor mutation burden with immune signatures in human cancers. Xiaosheng Wang, Mengyuan Li. BMC Immunol, 2019 Jan 13; 20(1). PMID: 30634925 Free PMC article. Highly Cited.
Tumor-infiltrating human CD4+ regulatory T cells display a distinct TCR repertoire and exhibit tumor and neoantigen reactivity. Mojgan Ahmadzadeh, Anna Pasetto, +4 authors, Steven A Rosenberg. less Sci Immunol, 2019 Jan 13; 4(31). PMID: 30635355 Free PMC article. Highly Cited.
IL-27 confers a protumorigenic activity of regulatory T cells via CD39. Young-Jun Park, Heeju Ryu, +4 authors, Yeonseok Chung. less Proc Natl Acad Sci U S A, 2019 Feb 06; 116(8). PMID: 30718407 Free PMC article.
Single-Cell Transcriptomics of Regulatory T Cells Reveals Trajectories of Tissue Adaptation. Ricardo J Miragaia, Tomás Gomes, +13 authors, Sarah A Teichmann. less Immunity, 2019 Feb 10; 50(2). PMID: 30737144 Free PMC article. Highly Cited.
LAYN Is a Prognostic Biomarker and Correlated With Immune Infiltrates in Gastric and Colon Cancers. Jing-Hua Pan, Hong Zhou, +6 authors, Lijun Rong. less Front Immunol, 2019 Feb 15; 10. PMID: 30761122 Free PMC article. Highly Cited.
Treg programming and therapeutic reprogramming in cancer. Mariela A Moreno Ayala, Zehui Li, Michel DuPage. Immunology, 2019 Mar 14; 157(3). PMID: 30866047 Free PMC article. Review.
Guidance factors orchestrating regulatory T cell positioning in tissues during development, homeostasis, and response. Thorsten R Mempel, Francesco Marangoni. Immunol Rev, 2019 Apr 13; 289(1). PMID: 30977195 Free PMC article. Review.
Regulation of regulatory T cells in cancer. Julie Stockis, Rahul Roychoudhuri, Timotheus Y F Halim. Immunology, 2019 Apr 30; 157(3). PMID: 31032905 Free PMC article. Review.
Dysregulation of EMT Drives the Progression to Clinically Aggressive Sarcomatoid Bladder Cancer. Charles C Guo, Tadeusz Majewski, +22 authors, Bogdan Czerniak. less Cell Rep, 2019 May 09; 27(6). PMID: 31067463 Free PMC article.
Identification of three subtypes of triple-negative breast cancer with potential therapeutic implications. Pascal Jézéquel, Olivier Kerdraon, +11 authors, Mario Campone. less Breast Cancer Res, 2019 May 19; 21(1). PMID: 31101122 Free PMC article.
Estimation of immune cell content in tumor using single-cell RNA-seq reference data. Xiaoqing Yu, Y Ann Chen, +2 authors, Xuefeng Wang. less BMC Cancer, 2019 Jul 22; 19(1). PMID: 31324168 Free PMC article.
Regulatory T Cells in Tumor Microenvironment and Approach for Anticancer Immunotherapy. Jung-Ho Kim, Beom Seok Kim, Sang-Kyou Lee. Immune Netw, 2020 Mar 12; 20(1). PMID: 32158592 Free PMC article. Review.
The role of FOXP3+ regulatory T cells in human autoimmune and inflammatory diseases. A Mohr, M Atif, +2 authors, R Balderas, G Gorochov, M Miyara. less Clin Exp Immunol, 2019 Mar 05; 197(1). PMID: 30830965 Free PMC article. Review.
Mechanisms of human FoxP3+ Treg cell development and function in health and disease. M Attias, T Al-Aubodah, C A Piccirillo. Clin Exp Immunol, 2019 Mar 14; 197(1). PMID: 30864147 Free PMC article. Review.
Relationships Between Immune Landscapes, Genetic Subtypes and Responses to Immunotherapy in Colorectal Cancer. Emilie Picard, Chris P Verschoor, Grace W Ma, Graham Pawelec. Front Immunol, 2020 Mar 27; 11. PMID: 32210966 Free PMC article. Review.
Depleting tumor-associated Tregs via nanoparticle-mediated hyperthermia to enhance anti-CTLA-4 immunotherapy. Hongwei Chen, Xin Luan, +7 authors, Duxin Sun. less Nanomedicine (Lond), 2019 Dec 24; 15(1). PMID: 31868112 Free PMC article.
Preferential Infiltration of Unique Vγ9Jγ2-Vδ2 T Cells Into Glioblastoma Multiforme. Mijeong Lee, Chanho Park, +8 authors, Tae Jin Kim. less Front Immunol, 2019 Apr 11; 10. PMID: 30967876 Free PMC article.
Tumour grade significantly correlates with total dysfunction of tumour tissue-infiltrating lymphocytes in renal cell carcinoma. Atsunari Kawashima, Takayuki Kanazawa, +19 authors, Norio Nonomura. less Sci Rep, 2020 Apr 12; 10(1). PMID: 32277125 Free PMC article.
Interleukin-1 and Related Cytokines in the Regulation of Inflammation and Immunity. Alberto Mantovani, Charles A Dinarello, Martina Molgora, Cecilia Garlanda. Immunity, 2019 Apr 18; 50(4). PMID: 30995499 Free PMC article. Highly Cited. Review.
The application and prospect of CDK4/6 inhibitors in malignant solid tumors. Qi Du, Xiang Guo, +3 authors, Miao Wang, Yongfu Li, Xiaoyi Sun, Qin Li. less J Hematol Oncol, 2020 May 03; 13(1). PMID: 32357912 Free PMC article. Review.
Targeting T cell activation in immuno-oncology. S D Saibil, P S Ohashi. Curr Oncol, 2020 May 06; 27(Suppl 2). PMID: 32368179 Free PMC article. Review.
The liver as an immunological barrier redefined by single-cell analysis. Zania Stamataki, Leo Swadling. Immunology, 2020 Mar 17; 160(2). PMID: 32176810 Free PMC article. Review.
Inducers, Attractors and Modulators of CD4+ Treg Cells in Non-Small-Cell Lung Cancer. Mengxiao Xie, Jia Wei, Jian Xu. Front Immunol, 2020 May 20; 11. PMID: 32425930 Free PMC article. Review.
Recirculation and Residency of T Cells and Tregs: Lessons Learnt in Anacapri. Silvia Piconese, Silvia Campello, Ambra Natalini. Front Immunol, 2020 May 21; 11. PMID: 32431695 Free PMC article. Review.
IRF4 instructs effector Treg differentiation and immune suppression in human cancer. Giorgia Alvisi, Jolanda Brummelman, +18 authors, Enrico Lugli. less J Clin Invest, 2020 Mar 04; 130(6). PMID: 32125291 Free PMC article.
Bcl6 Preserves the Suppressive Function of Regulatory T Cells During Tumorigenesis. Yiding Li, Zhiming Wang, +16 authors, Lifan Xu. less Front Immunol, 2020 Jun 02; 11. PMID: 32477338 Free PMC article.
A conserved intratumoral regulatory T cell signature identifies 4-1BB as a pan-cancer target. Zachary T Freeman, Thomas R Nirschl, +17 authors, Charles G Drake. less J Clin Invest, 2020 Feb 06; 130(3). PMID: 32015231 Free PMC article.
T1D progression is associated with loss of CD3+CD56+ regulatory T cells that control CD8+ T cell effector functions. Giuseppe Terrazzano, Sara Bruzzaniti, +20 authors, Mario Galgani. less Nat Metab, 2020 Jun 06; 2(2). PMID: 32500117 Free PMC article.
Assessment of Luminal and Basal Phenotypes in Bladder Cancer. Charles C Guo, Jolanta Bondaruk, +18 authors, Bogdan Czerniak. less Sci Rep, 2020 Jun 18; 10(1). PMID: 32546765 Free PMC article.
Regulatory T cells specifically suppress conventional CD8αβ T cells in intestinal tumors of APCMin/+ mice. Louis Szeponik, Paulina Akeus, +2 authors, William Rodin, Sukanya Raghavan, Marianne Quiding-Järbrink. less Cancer Immunol Immunother, 2020 Mar 19; 69(7). PMID: 32185408 Free PMC article.
Unravelling the heterogeneity and dynamic relationships of tumor-infiltrating T cells by single-cell RNA sequencing analysis. Xin Yu, Lei Zhang, +2 authors, Ashutosh Chaudhry, Aaron S Rapaport, Wenjun Ouyang. less J Leukoc Biol, 2020 Apr 10; 107(6). PMID: 32272497 Free PMC article. Review.
Intratumoral CD4+ T Cells Mediate Anti-tumor Cytotoxicity in Human Bladder Cancer. David Y Oh, Serena S Kwek, +17 authors, Lawrence Fong. less Cell, 2020 Jun 05; 181(7). PMID: 32497499 Free PMC article.
Tumor infiltrating T cells influence prognosis in stage I-III non-small cell lung cancer. Arik Bernard Schulze, Georg Evers, +6 authors, Birthe Heitkötter. less J Thorac Dis, 2020 Jul 10; 12(5). PMID: 32642087 Free PMC article.
Two gene set variation indexes as potential diagnostic tool for sepsis. Junyu Lu, Qian Li, +6 authors, Jianfeng Zhang. less Am J Transl Res, 2020 Jul 14; 12(6). PMID: 32655806 Free PMC article.
CD70 expression determines the therapeutic efficacy of expanded human regulatory T cells. Rebeca Arroyo Hornero, Christos Georgiadis, +8 authors, Joanna Hester. less Commun Biol, 2020 Jul 16; 3(1). PMID: 32665635 Free PMC article.
Circulating immune cell phenotype dynamics reflect the strength of tumor-immune cell interactions in patients during immunotherapy. Jason I Griffiths, Pierre Wallet, +13 authors, Andrea H Bild. less Proc Natl Acad Sci U S A, 2020 Jun 24; 117(27). PMID: 32571915 Free PMC article.
Analyzing and validating the prognostic value and mechanism of colon cancer immune microenvironment. Xinyi Wang, Jinzhong Duanmu, +2 authors, Xiaorui Fu, Taiyuan Li, Qunguang Jiang. less J Transl Med, 2020 Aug 30; 18(1). PMID: 32859214 Free PMC article.
Tumor-infiltrating CD62L+PD-1-CD8 T cells retain proliferative potential via Bcl6 expression and replenish effector T cells within the tumor. Yu Gong, Toshihiro Suzuki, +2 authors, Haruo Kozono, Masato Kubo, Naoko Nakano. less PLoS One, 2020 Aug 28; 15(8). PMID: 32845913 Free PMC article.
Clinical and prognostic significance of CC chemokine receptor type 8 protein expression in gastrointestinal stromal tumors. Huai-Liang Li, Lin-Hua Wang, +6 authors, Wan-Jiang Xue. less World J Gastroenterol, 2020 Sep 05; 26(31). PMID: 32884223 Free PMC article.
Layilin augments integrin activation to promote antitumor immunity. Kelly M Mahuron, Joshua M Moreau, +18 authors, Michael D Rosenblum. less J Exp Med, 2020 Jun 17; 217(9). PMID: 32539073 Free PMC article.
Turning the Tide Against Regulatory T Cells. SeongJun Han, Aras Toker, Zhe Qi Liu, Pamela S Ohashi. Front Oncol, 2019 May 07; 9. PMID: 31058083 Free PMC article. Review.
TP53 Mutations Promote Immunogenic Activity in Breast Cancer. Zhixian Liu, Zehang Jiang, +3 authors, Yingsheng Gao, Lirui Wang, Cai Chen, Xiaosheng Wang. less J Oncol, 2019 Jul 06; 2019. PMID: 31275382 Free PMC article.
Correlate the TP53 Mutation and the HRAS Mutation with Immune Signatures in Head and Neck Squamous Cell Cancer. Haoyu Lyu, Mengyuan Li, +2 authors, Zehang Jiang, Zhixian Liu, Xiaosheng Wang. less Comput Struct Biotechnol J, 2019 Aug 21; 17. PMID: 31428295 Free PMC article.
Human Tregs at the materno-fetal interface show site-specific adaptation reminiscent of tumor Tregs. Judith Wienke, Laura Brouwers, +5 authors, Femke van Wijk. less JCI Insight, 2020 Aug 19; 5(18). PMID: 32809975 Free PMC article.
Immunomodulation by anticancer cell cycle inhibitors. Giulia Petroni, Silvia C Formenti, Selina Chen-Kiang, Lorenzo Galluzzi. Nat Rev Immunol, 2020 Apr 30; 20(11). PMID: 32346095 Free PMC article. Review.
Ovarian Cancer Cells Promote Glycolysis Metabolism and TLR8-Mediated Metabolic Control of Human CD4+ T Cells. Wenwen Shang, Rui Xu, +3 authors, Ting Xu, Ming Wu, Juan Xu, Fang Wang. less Front Oncol, 2020 Oct 27; 10. PMID: 33102225 Free PMC article.
Intrahepatic TH17/TReg Cells in Homeostasis and Disease-It's All About the Balance. Hannah K Drescher, Lea M Bartsch, Sabine Weiskirchen, Ralf Weiskirchen. Front Pharmacol, 2020 Oct 31; 11. PMID: 33123017 Free PMC article. Review.
Comprehensive analysis of prognostic immune-related genes associated with the tumor microenvironment of pancreatic ductal adenocarcinoma. Shibai Yan, Juntao Fang, +2 authors, Yuanqiang Zhu, Yong Xie, Feng Fang. less Oncol Lett, 2020 Nov 03; 20(6). PMID: 33133266 Free PMC article.
Transcriptional Control of Regulatory T Cells in Cancer: Toward Therapeutic Targeting? Pierre Stéphan, Raphaëlle Lautraite, Allison Voisin, Yenkel Grinberg-Bleyer. Cancers (Basel), 2020 Nov 05; 12(11). PMID: 33143070 Free PMC article. Review.
CD39+ regulatory T cells accumulate in colon adenocarcinomas and display markers of increased suppressive function. Filip Ahlmanner, Patrik Sundström, +6 authors, Marianne Quiding-Järbrink. less Oncotarget, 2019 Jan 18; 9(97). PMID: 30651930 Free PMC article.
Tumors establish resistance to immunotherapy by regulating Treg recruitment via CCR4. Lisa A Marshall, Sachie Marubayashi, +16 authors, Oezcan Talay. less J Immunother Cancer, 2020 Nov 28; 8(2). PMID: 33243932 Free PMC article.
Immune suppressive landscape in the human esophageal squamous cell carcinoma microenvironment. Yingxia Zheng, Zheyi Chen, +16 authors, Lisong Shen. less Nat Commun, 2020 Dec 10; 11(1). PMID: 33293583 Free PMC article.
Lung Cancer Survival in Patients With Autoimmune Disease. Saya Jacob, Kian Rahbari, +8 authors, Victoria Villaflor. less JAMA Netw Open, 2020 Dec 15; 3(12). PMID: 33315114 Free PMC article.
Applications of Single-Cell Omics to Dissect Tumor Microenvironment. Tingting Guo, Weimin Li, Xuyu Cai. Front Genet, 2020 Dec 18; 11. PMID: 33329692 Free PMC article. Review.
Human Tissue-Resident Memory T Cells in the Maternal-Fetal Interface. Lost Soldiers or Special Forces? Caitlin S DeJong, Nicholas J Maurice, Stephen A McCartney, Martin Prlic. Cells, 2020 Dec 20; 9(12). PMID: 33339211 Free PMC article. Review.
Recirculating IL-1R2+ Tregs fine-tune intrathymic Treg development under inflammatory conditions. Eirini Nikolouli, Yassin Elfaki, +7 authors, Jochen Huehn. less Cell Mol Immunol, 2020 Jan 29; 18(1). PMID: 31988493 Free PMC article.
Alternative Pathways of IL-1 Activation, and Its Role in Health and Disease. Katerina Pyrillou, Laura C Burzynski, Murray C H Clarke. Front Immunol, 2021 Jan 05; 11. PMID: 33391283 Free PMC article. Review.
Interleukin-38 ameliorates poly(I:C) induced lung inflammation: therapeutic implications in respiratory viral infections. Xun Gao, Paul Kay Sheung Chan, +7 authors, Chun-Kwok Wong. less Cell Death Dis, 2021 Jan 09; 12(1). PMID: 33414457 Free PMC article.
TISCH: a comprehensive web resource enabling interactive single-cell transcriptome visualization of tumor microenvironment. Dongqing Sun, Jin Wang, +13 authors, Chenfei Wang. less Nucleic Acids Res, 2020 Nov 13; 49(D1). PMID: 33179754 Free PMC article.
Tissue-Resident Lymphocytes: Implications in Immunotherapy for Hepatocellular Carcinoma. Ji Won Han, Seung Kew Yoon. Int J Mol Sci, 2021 Jan 01; 22(1). PMID: 33379384 Free PMC article. Review.
Mechanisms of Immunosuppression in Colorectal Cancer. Yang Zhang, Ashwani Rajput, Ning Jin, Jing Wang. Cancers (Basel), 2021 Jan 10; 12(12). PMID: 33419310 Free PMC article. Review.
Oleic acid restores suppressive defects in tissue-resident FOXP3 Tregs from patients with multiple sclerosis. Saige L Pompura, Allon Wagner, +4 authors, David A Hafler. less J Clin Invest, 2020 Nov 11; 131(2). PMID: 33170805 Free PMC article.
Wilms' Tumor Primary Cells Display Potent Immunoregulatory Properties on NK Cells and Macrophages. Piera Filomena Fiore, Paola Vacca, +8 authors, Bruno Azzarone. less Cancers (Basel), 2021 Jan 14; 13(2). PMID: 33435455 Free PMC article.
IFN-γ and CD38 in Hyperprogressive Cancer Development. Stefania Angelicola, Francesca Ruzzi, +6 authors, Arianna Palladini. less Cancers (Basel), 2021 Jan 21; 13(2). PMID: 33467713 Free PMC article. Review.
Mapping the immune environment in clear cell renal carcinoma by single-cell genomics. Nicholas Borcherding, Ajaykumar Vishwakarma, +7 authors, Weizhou Zhang. less Commun Biol, 2021 Jan 29; 4(1). PMID: 33504936 Free PMC article.
Regulation of Treg Functions by the Ubiquitin Pathway. Elena Montauti, Deyu Fang. Adv Exp Med Biol, 2021 Feb 02; 1278. PMID: 33523442
Intestinal Regulatory T Cells. Vanessa R Figliuolo da Paz, Deepa R Jamwal, Pawel R Kiela. Adv Exp Med Biol, 2021 Feb 02; 1278. PMID: 33523448
Understanding and Targeting Human Cancer Regulatory T Cells to Improve Therapy. H Ryan Kolb, Nicholas Borcherding, Weizhou Zhang. Adv Exp Med Biol, 2021 Feb 02; 1278. PMID: 33523451
The Therapeutic Potential of Regulatory T Cells: Challenges and Opportunities. Fatemeh Bayati, Mahsa Mohammadi, +3 authors, Ehsan Sharif-Paghaleh. less Front Immunol, 2021 Feb 02; 11. PMID: 33519807 Free PMC article. Review.
Tumour heterogeneity and intercellular networks of nasopharyngeal carcinoma at single cell resolution. Yang Liu, Shuai He, +18 authors, Jin-Xin Bei. less Nat Commun, 2021 Feb 04; 12(1). PMID: 33531485 Free PMC article.
KRAS mutations are negatively correlated with immunity in colon cancer. Xiaorui Fu, Xinyi Wang, +2 authors, Jinzhong Duanmu, Taiyuan Li, Qunguang Jiang. less Aging (Albany NY), 2020 Dec 01; 13(1). PMID: 33254149 Free PMC article.
Evaluation of glucocorticoid-induced TNF receptor (GITR) expression in breast cancer and across multiple tumor types. Mayanne M T Zhu, Samantha Burugu, +5 authors, Torsten O Nielsen. less Mod Pathol, 2020 May 01; 33(9). PMID: 32350416
The Adhesome Network: Key Components Shaping the Tumour Stroma. Pinelopi A Nikolopoulou, Maria A Koufaki, Vassiliki Kostourou. Cancers (Basel), 2021 Feb 13; 13(3). PMID: 33573141 Free PMC article. Review.
Modulation of regulatory T cell function and stability by co-inhibitory receptors. Liliana E Lucca, Margarita Dominguez-Villar. Nat Rev Immunol, 2020 Apr 10; 20(11). PMID: 32269380 Review.
Single-Cell Analysis Reveals Characterization of Infiltrating T Cells in Moderately Differentiated Colorectal Cancer. Xi Yang, Quan Qi, +6 authors, Shuwen Han. less Front Immunol, 2021 Feb 16; 11. PMID: 33584715 Free PMC article.
Interleukin-1 as Innate Mediator of T Cell Immunity. Bram Van Den Eeckhout, Jan Tavernier, Sarah Gerlo. Front Immunol, 2021 Feb 16; 11. PMID: 33584721 Free PMC article. Review.
CCR8 blockade primes anti-tumor immunity through intratumoral regulatory T cells destabilization in muscle-invasive bladder cancer. Tao Wang, Quan Zhou, +17 authors, Jiejie Xu. less Cancer Immunol Immunother, 2020 May 06; 69(9). PMID: 32367308
Systems biology analysis identifies TNFRSF9 as a functional marker of tumor-infiltrating regulatory T-cell enabling clinical outcome prediction in lung cancer. Jae-Won Cho, Jimin Son, Sang-Jun Ha, Insuk Lee. Comput Struct Biotechnol J, 2021 Feb 19; 19. PMID: 33598101 Free PMC article.
Common clonal origin of conventional T cells and induced regulatory T cells in breast cancer patients. Maria Xydia, Raheleh Rahbari, +22 authors, Philipp Beckhove. less Nat Commun, 2021 Feb 20; 12(1). PMID: 33602930 Free PMC article.
Progress and Clinical Application of Single-Cell Transcriptional Sequencing Technology in Cancer Research. Jian Liu, Tianmin Xu, +2 authors, Yuemei Jin, Bingyu Huang, Yan Zhang. less Front Oncol, 2021 Feb 23; 10. PMID: 33614479 Free PMC article. Review.
Crosstalk between Macrophages, T Cells, and Iron Metabolism in Tumor Microenvironment. Lesang Shen, Yunxiang Zhou, +6 authors, Jian Huang. less Oxid Med Cell Longev, 2021 Feb 26; 2021. PMID: 33628389 Free PMC article. Review.
Screening and Identification of Four Prognostic Genes Related to Immune Infiltration and G-Protein Coupled Receptors Pathway in Lung Adenocarcinoma. Yan Wang, Liwei Qiu, +3 authors, Yu Chen, Xia Zhang, Peng Yang, Feng Xu. less Front Oncol, 2021 Feb 26; 10. PMID: 33628734 Free PMC article.
Age-Related Gene Alteration in Naïve and Memory T cells Using Precise Age-Tracking Model. Xiaofeng Yang, Xin Wang, +17 authors, Baojun Zhang. less Front Cell Dev Biol, 2021 Mar 02; 8. PMID: 33644036 Free PMC article.
Therapeutic depletion of CCR8+ tumor-infiltrating regulatory T cells elicits antitumor immunity and synergizes with anti-PD-1 therapy. Helena Van Damme, Bruno Dombrecht, +26 authors, Jo Agnes Van Ginderachter. less J Immunother Cancer, 2021 Feb 17; 9(2). PMID: 33589525 Free PMC article.
Advances in Human Immune System Mouse Models for Personalized Treg-Based Immunotherapies. Isabelle Serr, Maria Kral, Martin G Scherm, Carolin Daniel. Front Immunol, 2021 Mar 09; 12. PMID: 33679808 Free PMC article. Review.
The Impact of Tregs on the Anticancer Immunity and the Efficacy of Immune Checkpoint Inhibitor Therapies. Jose M González-Navajas, Dengxia Denise Fan, +4 authors, Jongdae Lee. less Front Immunol, 2021 Mar 16; 12. PMID: 33717139 Free PMC article. Review.
A Simplified Amino Acidic Alphabet to Unveil the T-Cells Receptors Antigens: A Computational Perspective. Raffaele Iannuzzi, Grazisa Rossetti, +3 authors, Luca Mollica. less Front Chem, 2021 Mar 16; 9. PMID: 33718327 Free PMC article.
Critical Roles of Balanced T Helper 9 Cells and Regulatory T Cells in Allergic Airway Inflammation and Tumor Immunity. Muhua Huang, Jingcheng Dong. J Immunol Res, 2021 Mar 23; 2021. PMID: 33748292 Free PMC article. Review.
Protective low-avidity anti-tumour CD8+ T cells are selectively attenuated by regulatory T cells. Gessa Sugiyarto, David Prossor, +3 authors, Edward James. less Immunother Adv, 2021 Mar 23; 1(1). PMID: 33748824 Free PMC article.
Single-Cell Sequencing, an Advanced Technology in Lung Cancer Research. Hao Wang, Die Meng, +14 authors, Yayi He. less Onco Targets Ther, 2021 Mar 25; 14. PMID: 33758510 Free PMC article. Review.
Preoperative immune landscape predisposes adverse outcomes in hepatocellular carcinoma patients with liver transplantation. Sang-Ho Yoon, Seo-Won Choi, +2 authors, Suk Woo Nam, Kyoung Bun Lee, Jin-Wu Nam. less NPJ Precis Oncol, 2021 Mar 28; 5(1). PMID: 33772139 Free PMC article.
Immunosuppressive Cell Subsets and Factors in Myeloid Leukemias. Julian Swatler, Laura Turos-Korgul, Ewa Kozlowska, Katarzyna Piwocka. Cancers (Basel), 2021 Apr 04; 13(6). PMID: 33801964 Free PMC article. Review.
IL-1R2 expression in human gastric cancer and its clinical significance. Maoling Yuan, Lei Wang, +4 authors, Jingting Jiang. less Biosci Rep, 2021 Mar 12; 41(3). PMID: 33704402 Free PMC article.
Improved understanding of gastrointestinal stromal tumors biology as a step for developing new diagnostic and therapeutic schemes. Marta Magdalena Fudalej, Anna Maria Badowska-Kozakiewicz. Oncol Lett, 2021 Apr 13; 21(5). PMID: 33841578 Free PMC article. Review.
ADPRH is a prognosis-related biomarker and correlates with immune infiltrates in low grade glioma. Chunyu Zhang, Long Wang, +7 authors, Daofeng Tian. less J Cancer, 2021 Apr 16; 12(10). PMID: 33854592 Free PMC article.
Immunotherapy for Hepatocellular Carcinoma: Current Limits and Prospects. Cheng Zhong, Yirun Li, +5 authors, Hui Lin. less Front Oncol, 2021 Apr 16; 11. PMID: 33854960 Free PMC article. Review.
Single-Cell Sequencing Reveals the Transcriptome and TCR Characteristics of pTregs and in vitro Expanded iTregs. Zhenzhen Hui, Jiali Zhang, +5 authors, Xiubao Ren. less Front Immunol, 2021 Apr 20; 12. PMID: 33868236 Free PMC article.
Single-cell chromatin accessibility landscape identifies tissue repair program in human regulatory T cells. Michael Delacher, Malte Simon, +26 authors, Markus Feuerer. less Immunity, 2021 Apr 01; 54(4). PMID: 33789089 Free PMC article.
Single-cell RNA-seq reveals dynamic change in tumor microenvironment during pancreatic ductal adenocarcinoma malignant progression. Kai Chen, Qi Wang, +5 authors, Yinmo Yang. less EBioMedicine, 2021 Apr 06; 66. PMID: 33819739 Free PMC article.
Exhaustion in tumor-infiltrating Mucosal-Associated Invariant T (MAIT) cells from colon cancer patients. William Rodin, Patrik Sundström, +5 authors, Marianne Quiding Järbrink. less Cancer Immunol Immunother, 2021 Apr 23; 70(12). PMID: 33885944 Free PMC article.
TNFR2: Role in Cancer Immunology and Immunotherapy. Yang Yang, Md Sahidul Islam, Yuanjia Hu, Xin Chen. Immunotargets Ther, 2021 Apr 29; 10. PMID: 33907692 Free PMC article. Review.
GBP5 Repression Suppresses the Metastatic Potential and PD-L1 Expression in Triple-Negative Breast Cancer. Shun-Wen Cheng, Po-Chih Chen, +3 authors, Yuan-Feng Lin. less Biomedicines, 2021 May 01; 9(4). PMID: 33916322 Free PMC article.
Hyperprogressive Disease: Main Features and Key Controversies. Hugo Arasanz, Miren Zuazo, +15 authors, Ruth Vera. less Int J Mol Sci, 2021 May 01; 22(7). PMID: 33916696 Free PMC article. Review.
Recruitment and Expansion of Tregs Cells in the Tumor Environment-How to Target Them? Justine Cinier, Margaux Hubert, +5 authors, Christine Ménétrier-Caux. less Cancers (Basel), 2021 May 01; 13(8). PMID: 33924428 Free PMC article. Review.
STARTRAC analyses of scRNAseq data from tumor models reveal T cell dynamics and therapeutic targets. Dev Bhatt, Boxi Kang, +13 authors, Wenjun Ouyang. less J Exp Med, 2021 Apr 27; 218(6). PMID: 33900375 Free PMC article.
Conserved human effector Treg cell transcriptomic and epigenetic signature in arthritic joint inflammation. Gerdien Mijnheer, Lisanne Lutter, +16 authors, Femke van Wijk. less Nat Commun, 2021 May 13; 12(1). PMID: 33976194 Free PMC article.
Clonally expanded EOMES+ Tr1-like cells in primary and metastatic tumors are associated with disease progression. Raoul J P Bonnal, Grazisa Rossetti, +43 authors, Massimiliano Pagani. less Nat Immunol, 2021 May 22; 22(6). PMID: 34017124
Natural Killer Cell Interactions With Myeloid Derived Suppressor Cells in the Tumor Microenvironment and Implications for Cancer Immunotherapy. Cristina Zalfa, Silke Paust. Front Immunol, 2021 May 25; 12. PMID: 34025641 Free PMC article. Review.
PP2A in LepR+ mesenchymal stem cells contributes to embryonic and postnatal endochondral ossification through Runx2 dephosphorylation. Yu-Ting Yen, May Chien, Pei-Yi Wu, Shih-Chieh Hung. Commun Biol, 2021 Jun 04; 4(1). PMID: 34079065 Free PMC article.
A risk model developed based on tumor microenvironment predicts overall survival and associates with tumor immunity of patients with lung adenocarcinoma. Jie Wu, Lan Li, +4 authors, Bin Xu. less Oncogene, 2021 Jun 11; 40(26). PMID: 34108619
Peritumoral Tertiary Lymphoid Structures Correlate With Protective Immunity and Improved Prognosis in Patients With Hepatocellular Carcinoma. Hui Li, Hailing Liu, +4 authors, Hong Wu. less Front Immunol, 2021 Jun 15; 12. PMID: 34122408 Free PMC article.
Intratumoral follicular regulatory T cells curtail anti-PD-1 treatment efficacy. Simon Eschweiler, James Clarke, +14 authors, Pandurangan Vijayanand. less Nat Immunol, 2021 Jun 26; 22(8). PMID: 34168370 Free PMC article.
Single-cell analyses reveal suppressive tumor microenvironment of human colorectal cancer. Yan Mei, Weiwei Xiao, +15 authors, Guangshuai Jia. less Clin Transl Med, 2021 Jun 30; 11(6). PMID: 34185431 Free PMC article.
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T Cell-Intrinsic CDK6 Is Dispensable for Anti-Viral and Anti-Tumor Responses In Vivo. Klara Klein, Agnieszka Witalisz-Siepracka, +6 authors, Veronika Sexl. less Front Immunol, 2021 Jul 13; 12. PMID: 34248938 Free PMC article.
CCR8 marks highly suppressive Treg cells within tumours but is dispensable for their accumulation and suppressive function. Sarah K Whiteside, Francis M Grant, +14 authors, Rahul Roychoudhuri. less Immunology, 2021 Apr 11; 163(4). PMID: 33838058 Free PMC article.
CD30+OX40+ Treg is associated with improved overall survival in colorectal cancer. Jian Hang Lam, Michelle Hong, +10 authors, Tong Seng Lim. less Cancer Immunol Immunother, 2021 Feb 03; 70(8). PMID: 33527196 Free PMC article.
Identification of Prognostic miRNAs Associated With Immune Cell Tumor Infiltration Predictive of Clinical Outcomes in Patients With Non-Small Cell Lung Cancer. Yuepeng Zhang, Kai Mi, +5 authors, Shoude Jin. less Front Oncol, 2021 Jul 20; 11. PMID: 34277450 Free PMC article.
Regulatory T-cell Transcriptomic Reprogramming Characterizes Adverse Events by Checkpoint Inhibitors in Solid Tumors. Maria Grigoriou, Aggelos Banos, +13 authors, Panayotis Verginis. less Cancer Immunol Res, 2021 Apr 07; 9(7). PMID: 33820810 Free PMC article.
TIGIT, the Next Step Towards Successful Combination Immune Checkpoint Therapy in Cancer. Zhouhong Ge, Maikel P Peppelenbosch, Dave Sprengers, Jaap Kwekkeboom. Front Immunol, 2021 Aug 10; 12. PMID: 34367161 Free PMC article. Review.
Intratumoral regulatory T cells from colon cancer patients comprise several activated effector populations. Louis Szeponik, Filip Ahlmanner, +5 authors, Marianne Quiding-Järbrink. less BMC Immunol, 2021 Aug 20; 22(1). PMID: 34407765 Free PMC article.
PIP4Ks impact on PI3K, FOXP3, and UHRF1 signaling and modulate human regulatory T cell proliferation and immunosuppressive activity. Alessandro Poli, Shidqiyyah Abdul-Hamid, +7 authors, Nullin Divecha. less Proc Natl Acad Sci U S A, 2021 Jul 28; 118(31). PMID: 34312224 Free PMC article.
Mechanisms of regulatory T cell infiltration in tumors: implications for innovative immune precision therapies. Hiroyoshi Nishikawa, Shohei Koyama. J Immunother Cancer, 2021 Aug 01; 9(7). PMID: 34330764 Free PMC article. Review.
Natural killer cells and cytotoxic T lymphocytes are required to clear solid tumor in a patient-derived xenograft. Duy Tri Le, Tridu R Huynh, +7 authors, Silke Paust. less JCI Insight, 2021 Jun 04; 6(13). PMID: 34081628 Free PMC article.
Chemokines and the immune response to cancer. Aleksandra J Ozga, Melvyn T Chow, Andrew D Luster. Immunity, 2021 Apr 12; 54(5). PMID: 33838745 Free PMC article. Review.
GDF15 induces immunosuppression via CD48 on regulatory T cells in hepatocellular carcinoma. Zhaowei Wang, Lei He, +19 authors, Meng Li. less J Immunother Cancer, 2021 Sep 08; 9(9). PMID: 34489334 Free PMC article.
Editorial: CD4+ T Cells in Cancer Immunotherapies. José M González-Navajas, Eyad Elkord, Jongdae Lee. Front Immunol, 2021 Sep 24; 12. PMID: 34552596 Free PMC article.
CD177 modulates the function and homeostasis of tumor-infiltrating regulatory T cells. Myung-Chul Kim, Nicholas Borcherding, +32 authors, Weizhou Zhang. less Nat Commun, 2021 Oct 03; 12(1). PMID: 34599187 Free PMC article.
Profound Treg perturbations correlate with COVID-19 severity. Silvia Galván-Peña, Juliette Leon, +16 authors, Christophe Benoist. less Proc Natl Acad Sci U S A, 2021 Aug 27; 118(37). PMID: 34433692 Free PMC article.
Layilin Anchors Regulatory T Cells in Skin. Pooja Mehta, Victoire Gouirand, +20 authors, Michael D Rosenblum. less J Immunol, 2021 Sep 03; 207(7). PMID: 34470859 Free PMC article.
Effector T cell responses unleashed by regulatory T cell ablation exacerbate oral squamous cell carcinoma. Jaime L Chao, Michael Korzinkin, +6 authors, Peter A Savage. less Cell Rep Med, 2021 Oct 09; 2(9). PMID: 34622236 Free PMC article.
Regulatory T-Cells and Multiple Myeloma: Implications in Tumor Immune Biology and Treatment. Christina Hadjiaggelidou, Eirini Katodritou. J Clin Med, 2021 Oct 14; 10(19). PMID: 34640606 Free PMC article. Review.
Integrated analysis reveals distinct molecular, clinical, and immunological features of B7-H3 in acute myeloid leukemia. Ling-Yi Zhang, Ye Jin, +9 authors, Jun Qian. less Cancer Med, 2021 Sep 26; 10(21). PMID: 34562306 Free PMC article.
mTOR-dependent translation drives tumor infiltrating CD8+ effector and CD4+ Treg cells expansion. Benedetta De Ponte Conti, Annarita Miluzio, +3 authors, Sara Ricciardi. less Elife, 2021 Nov 18; 10. PMID: 34787568 Free PMC article.
Novel CircRNAs in Hub ceRNA Axis Regulate Gastric Cancer Prognosis and Microenvironment. Xianghui Li, Zhiyan Li, +7 authors, Song Liu. less Front Med (Lausanne), 2021 Nov 26; 8. PMID: 34820403 Free PMC article.
Immune checkpoint inhibition for pancreatic ductal adenocarcinoma: limitations and prospects: a systematic review. Hong-Bo Li, Zi-Han Yang, Qing-Qu Guo. Cell Commun Signal, 2021 Nov 26; 19(1). PMID: 34819086 Free PMC article. Review.
Chemokine Pathways in Cutaneous Melanoma: Their Modulation by Cancer and Exploitation by the Clinician. Rebecca Adams, Bernhard Moser, Sophia N Karagiannis, Katie E Lacy. Cancers (Basel), 2021 Nov 28; 13(22). PMID: 34830780 Free PMC article. Review.
Pushing Past the Blockade: Advancements in T Cell-Based Cancer Immunotherapies. Jessica Waibl Polania, Emily C Lerner, +2 authors, Peter E Fecci. less Front Immunol, 2021 Dec 07; 12. PMID: 34868044 Free PMC article. Review.
Personalized Immunotherapy in Colorectal Cancers: Where Do We Stand? Li-Feng Hu, Huan-Rong Lan, +2 authors, Dong Huang, Xue-Min Li, Ke-Tao Jin. less Front Oncol, 2021 Dec 11; 11. PMID: 34888246 Free PMC article. Review.
Application and prospects of single cell sequencing in tumors. Ruo Han Huang, Le Xin Wang, Jing He, Wen Gao. Biomark Res, 2021 Dec 14; 9(1). PMID: 34895349 Free PMC article. Review.
Expansion of tumor-associated Treg cells upon disruption of a CTLA-4-dependent feedback loop. Francesco Marangoni, Ademi Zhakyp, +10 authors, Thorsten R Mempel. less Cell, 2021 Jun 23; 184(15). PMID: 34157302 Free PMC article.
Depletion of central memory CD8+ T cells might impede the antitumor therapeutic effect of Mogamulizumab. Yuka Maeda, Hisashi Wada, +17 authors, Hiroyoshi Nishikawa. less Nat Commun, 2021 Dec 16; 12(1). PMID: 34907192 Free PMC article.
Single cell analysis of spondyloarthritis regulatory T cells identifies distinct synovial gene expression patterns and clonal fates. Davide Simone, Frank Penkava, +3 authors, Paul Bowness. less Commun Biol, 2021 Dec 16; 4(1). PMID: 34907325 Free PMC article.
Breast cancer metastasis: immune profiling of lymph nodes reveals exhaustion of effector T cells and immunosuppression. Inga Hansine Rye, Kanutte Huse, +9 authors, Hege G Russnes. less Mol Oncol, 2021 Jun 25; 16(1). PMID: 34165864 Free PMC article.
Tumor-Associated Regulatory T Cell Expression of LAIR2 Is Prognostic in Lung Adenocarcinoma. Dalam Ly, Quan Li, +6 authors, Li Zhang. less Cancers (Basel), 2022 Jan 12; 14(1). PMID: 35008369 Free PMC article.
Spatial immune heterogeneity of hypoxia-induced exhausted features in high-grade glioma. A-Reum Kim, Seong Jin Choi, +9 authors, Eui-Cheol Shin. less Oncoimmunology, 2022 Jan 18; 11(1). PMID: 35036078 Free PMC article.
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Single-Cell RNA Sequencing in Lung Cancer: Revealing Phenotype Shaping of Stromal Cells in the Microenvironment. Jianhong Zhang, Chengyang Song, Ye Tian, Xueying Yang. Front Immunol, 2022 Feb 08; 12. PMID: 35126365 Free PMC article. Review.
Functional and molecular characterization of PD1+ tumor-infiltrating lymphocytes from lung cancer patients. Jesse J Lipp, Limei Wang, +14 authors, Sean R R Hall. less Oncoimmunology, 2022 Feb 15; 11(1). PMID: 35154905 Free PMC article.
CCR8-targeted specific depletion of clonally expanded Treg cells in tumor tissues evokes potent tumor immunity with long-lasting memory. Yujiro Kidani, Wataru Nogami, +39 authors, Shimon Sakaguchi. less Proc Natl Acad Sci U S A, 2022 Feb 11; 119(7). PMID: 35140181 Free PMC article.
Chemokine Receptor-Targeted Therapies: Special Case for CCR8. Bernhard Moser. Cancers (Basel), 2022 Feb 16; 14(3). PMID: 35158783 Free PMC article. Review.
Negative Regulation of the IL-1 System by IL-1R2 and IL-1R8: Relevance in Pathophysiology and Disease. Domenico Supino, Luna Minute, +3 authors, Cecilia Garlanda. less Front Immunol, 2022 Feb 26; 13. PMID: 35211118 Free PMC article. Review.
4-1BBL-containing leukemic extracellular vesicles promote immunosuppressive effector regulatory T cells. Julian Swatler, Laura Turos-Korgul, +16 authors, Katarzyna Piwocka. less Blood Adv, 2022 Feb 08; 6(6). PMID: 35130345 Free PMC article.
Tissue Resident Foxp3+ Regulatory T Cells: Sentinels and Saboteurs in Health and Disease. Juyeun Lee, Dongkyun Kim, Booki Min. Front Immunol, 2022 Apr 02; 13. PMID: 35359918 Free PMC article. Review.
The impact of CCR8+ regulatory T cells on cytotoxic T cell function in human lung cancer. Miya Haruna, Azumi Ueyama, +13 authors, Hisashi Wada. less Sci Rep, 2022 Apr 01; 12(1). PMID: 35354899 Free PMC article.
Prevalence of intratumoral regulatory T cells expressing neuropilin-1 is associated with poorer outcomes in patients with cancer. Christopher A Chuckran, Anthony R Cillo, +26 authors, Dario A A Vignali. less Sci Transl Med, 2021 Dec 09; 13(623). PMID: 34878821 Free PMC article.
Direct targeting of FOXP3 in Tregs with AZD8701, a novel antisense oligonucleotide to relieve immunosuppression in cancer. Alexey Revenko, Larissa S Carnevalli, +25 authors, A Robert MacLeod. less J Immunother Cancer, 2022 Apr 08; 10(4). PMID: 35387780 Free PMC article.
A Risk Model Developed Based on Necroptosis Predicts Overall Survival for Hepatocellular Carcinoma and Identification of Possible Therapeutic Drugs. Zedong Li, Jianyu Fang, +5 authors, Yu Peng. less Front Immunol, 2022 Apr 16; 13. PMID: 35422802 Free PMC article.
Exploring the Mechanisms Underlying the Cardiotoxic Effects of Immune Checkpoint Inhibitor Therapies. Daniel Ronen, Aseel Bsoul, +4 authors, Rabea Asleh. less Vaccines (Basel), 2022 Apr 24; 10(4). PMID: 35455289 Free PMC article. Review.
Different subpopulations of regulatory T cells in human autoimmune disease, transplantation, and tumor immunity. Zhongyi Jiang, Haitao Zhu, +4 authors, Futian Du. less MedComm (2020), 2022 Apr 28; 3(2). PMID: 35474948 Free PMC article. Review.
Tumor-Associated Regulatory T Cells in Non-Small-Cell Lung Cancer: Current Advances and Future Perspectives. Jiaqi Liang, Guoshu Bi, +3 authors, Guangyao Shan, Xing Jin, Yunyi Bian, Qun Wang. less J Immunol Res, 2022 May 03; 2022. PMID: 35497874 Free PMC article. Review.
Landscape of helper and regulatory antitumour CD4+ T cells in melanoma. Giacomo Oliveira, Kari Stromhaug, +24 authors, Catherine J Wu. less Nature, 2022 May 05; 605(7910). PMID: 35508657
Identification of Tumor Microenvironment and DNA Methylation-Related Prognostic Signature for Predicting Clinical Outcomes and Therapeutic Responses in Cervical Cancer. Bangquan Liu, Jiabao Zhai, +6 authors, Fubin Zhang. less Front Mol Biosci, 2022 May 07; 9. PMID: 35517856 Free PMC article.
Single-cell landscape of immunocytes in patients with extrahepatic cholangiocarcinoma. Lei Xu, Yun Lu, +5 authors, Jianming Wang. less J Transl Med, 2022 May 14; 20(1). PMID: 35562760 Free PMC article.

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