Journal Article
. 2016 Nov; 17(1):231.
doi: 10.1186/s13059-016-1092-z.

Tumor immune microenvironment characterization in clear cell renal cell carcinoma identifies prognostic and immunotherapeutically relevant messenger RNA signatures

Yasin Şenbabaoğlu 1 Ron S Gejman 2 Andrew G Winer 3 Ming Liu 4 Eliezer M Van Allen 5 Guillermo de Velasco 5 Diana Miao 5 Irina Ostrovnaya 6 Esther Drill 6 Augustin Luna 7 Nils Weinhold 7 William Lee 7 Brandon J Manley 3 Danny N Khalil 8 Samuel D Kaffenberger 3 Yingbei Chen 9 Ludmila Danilova 10 Martin H Voss 11 Jonathan A Coleman 3 Paul Russo 3 Victor E Reuter 9 Timothy A Chan 12 Emily H Cheng 9 David A Scheinberg 2 Ming O Li 4 Toni K Choueiri 5 James J Hsieh 11 Chris Sander 7 A Ari Hakimi 13 
Affiliations
  • PMID: 27855702
  •     84 References
  •     301 citations

Abstract

Background: Tumor-infiltrating immune cells have been linked to prognosis and response to immunotherapy; however, the levels of distinct immune cell subsets and the signals that draw them into a tumor, such as the expression of antigen presenting machinery genes, remain poorly characterized. Here, we employ a gene expression-based computational method to profile the infiltration levels of 24 immune cell populations in 19 cancer types.

Results: We compare cancer types using an immune infiltration score and a T cell infiltration score and find that clear cell renal cell carcinoma (ccRCC) is among the highest for both scores. Using immune infiltration profiles as well as transcriptomic and proteomic datasets, we characterize three groups of ccRCC tumors: T cell enriched, heterogeneously infiltrated, and non-infiltrated. We observe that the immunogenicity of ccRCC tumors cannot be explained by mutation load or neo-antigen load, but is highly correlated with MHC class I antigen presenting machinery expression (APM). We explore the prognostic value of distinct T cell subsets and show in two cohorts that Th17 cells and CD8+ T/Treg ratio are associated with improved survival, whereas Th2 cells and Tregs are associated with negative outcomes. Investigation of the association of immune infiltration patterns with the subclonal architecture of tumors shows that both APM and T cell levels are negatively associated with subclone number.

Conclusions: Our analysis sheds light on the immune infiltration patterns of 19 human cancers and unravels mRNA signatures with prognostic utility and immunotherapeutic biomarker potential in ccRCC.

Keywords: Cancer immunotherapy; Checkpoint blockade; Clear cell renal cell carcinoma (ccRCC); Computational deconvolution; Tumor immune microenvironment.

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Roberta Zappasodi, Taha Merghoub, Jedd D Wolchok.
Cancer Cell, 2018 Apr 11; 33(4). PMID: 29634946    Free PMC article.
Highly Cited. Review.
Mining TCGA database for genes of prognostic value in glioblastoma microenvironment.
Di Jia, Shenglan Li, +3 authors, Ying Liu.
Aging (Albany NY), 2018 Apr 21; 10(4). PMID: 29676997    Free PMC article.
Highly Cited.
Potent immunogenicity in BRCA1-mutated patients with high-grade serous ovarian carcinoma.
Ying Dai, Chengdu Sun, +2 authors, Bo Zhu.
J Cell Mol Med, 2018 Jun 02; 22(8). PMID: 29855141    Free PMC article.
Immune cell profiling in cancer: molecular approaches to cell-specific identification.
Yasmin A Lyons, Sherry Y Wu, +2 authors, Anil K Sood.
NPJ Precis Oncol, 2018 Jun 07; 1(1). PMID: 29872708    Free PMC article.
Highly Cited. Review.
An Empirical Approach Leveraging Tumorgrafts to Dissect the Tumor Microenvironment in Renal Cell Carcinoma Identifies Missing Link to Prognostic Inflammatory Factors.
Tao Wang, Rong Lu, +28 authors, James Brugarolas.
Cancer Discov, 2018 Jun 10; 8(9). PMID: 29884728    Free PMC article.
seq-ImmuCC: Cell-Centric View of Tissue Transcriptome Measuring Cellular Compositions of Immune Microenvironment From Mouse RNA-Seq Data.
Ziyi Chen, Lijun Quan, +8 authors, Aiping Wu.
Front Immunol, 2018 Jun 21; 9. PMID: 29922297    Free PMC article.
Pan-cancer adaptive immune resistance as defined by the Tumor Inflammation Signature (TIS): results from The Cancer Genome Atlas (TCGA).
Patrick Danaher, Sarah Warren, +6 authors, Alessandra Cesano.
J Immunother Cancer, 2018 Jun 23; 6(1). PMID: 29929551    Free PMC article.
Highly Cited.
Perspectives in immunotherapy: meeting report from the Immunotherapy Bridge (29-30 November, 2017, Naples, Italy).
Paolo A Ascierto, James Brugarolas, +16 authors, Igor Puzanov.
J Immunother Cancer, 2018 Jul 13; 6(1). PMID: 29996914    Free PMC article.
Review.
Immunological-based approaches for cancer therapy.
Luciana Barros, Marco Antonio Pretti, +3 authors, Martin Hernán Bonamino.
Clinics (Sao Paulo), 2018 Aug 23; 73(suppl 1). PMID: 30133560    Free PMC article.
Review.
Characterization of the Neuroendocrine Tumor Immune Microenvironment.
Annacarolina da Silva, Michaela Bowden, +10 authors, Matthew H Kulke.
Pancreas, 2018 Aug 29; 47(9). PMID: 30153220    Free PMC article.
Tumor infiltrating CD19+ B lymphocytes predict prognostic and therapeutic benefits in metastatic renal cell carcinoma patients treated with tyrosine kinase inhibitors.
Zhiyuan Lin, Li Liu, +7 authors, Jiejie Xu.
Oncoimmunology, 2018 Oct 06; 7(10). PMID: 30288343    Free PMC article.
Molecular Classification of Renal Cell Carcinoma and Its Implication in Future Clinical Practice.
Jozefina Casuscelli, Yann-Alexandre Vano, Wolf Herve Fridman, James J Hsieh.
Kidney Cancer, 2017 Jul 26; 1(1). PMID: 30334000    Free PMC article.
Review.
Chromosome 3p Loss-Orchestrated VHL, HIF, and Epigenetic Deregulation in Clear Cell Renal Cell Carcinoma.
James J Hsieh, Valerie H Le, +3 authors, Emily H Cheng.
J Clin Oncol, 2018 Oct 30;. PMID: 30372397    Free PMC article.
Review.
Tumor-infiltrating neutrophils predict therapeutic benefit of tyrosine kinase inhibitors in metastatic renal cell carcinoma.
Jiajun Wang, Li Liu, +7 authors, Jiejie Xu.
Oncoimmunology, 2018 Dec 14; 8(1). PMID: 30546957    Free PMC article.
Immune and genomic correlates of response to anti-PD-1 immunotherapy in glioblastoma.
Junfei Zhao, Andrew X Chen, +24 authors, Raul Rabadan.
Nat Med, 2019 Feb 12; 25(3). PMID: 30742119    Free PMC article.
Highly Cited.
Chemoimmunotherapy in Advanced Renal Cell Carcinoma: A Case Report of a Long-Term Survivor Adjunctly Treated with Viscum album Extracts.
Paul G Werthmann, Lothar Kindermann, Gunver S Kienle.
Complement Med Res, 2019 Mar 22; 26(4). PMID: 30897582    Free PMC article.
Tumor Microenvironment Dynamics in Clear-Cell Renal Cell Carcinoma.
Lynda Vuong, Ritesh R Kotecha, Martin H Voss, A Ari Hakimi.
Cancer Discov, 2019 Sep 19; 9(10). PMID: 31527133    Free PMC article.
Review.
Profiles of tumor-infiltrating immune cells in renal cell carcinoma and their clinical implications.
Gongmin Zhu, Lijiao Pei, +5 authors, Xin Gou.
Oncol Lett, 2019 Oct 16; 18(5). PMID: 31612034    Free PMC article.
A Pan-Cancer Approach to Predict Responsiveness to Immune Checkpoint Inhibitors by Machine Learning.
Maurizio Polano, Marco Chierici, +6 authors, Giuseppe Toffoli.
Cancers (Basel), 2019 Oct 18; 11(10). PMID: 31618839    Free PMC article.
miR-22 Regulates Invasion, Gene Expression and Predicts Overall Survival in Patients with Clear Cell Renal Cell Carcinoma.
Xue Gong, Hongjuan Zhao, +2 authors, James D Brooks.
Kidney Cancer, 2019 Nov 26; 3(2). PMID: 31763513    Free PMC article.
Antigen presentation and tumor immunogenicity in cancer immunotherapy response prediction.
Shixiang Wang, Zaoke He, +2 authors, Xue-Song Liu.
Elife, 2019 Nov 27; 8. PMID: 31767055    Free PMC article.
Identification of prognostic genes in the acute myeloid leukemia microenvironment.
Shaoxin Huang, Biyu Zhang, +4 authors, Denggang Fu.
Aging (Albany NY), 2019 Nov 20; 11(22). PMID: 31740623    Free PMC article.
Prognostic genes in the tumor microenvironment in cervical squamous cell carcinoma.
Xin-Bin Pan, Yan Lu, +2 authors, De-Sheng Yao.
Aging (Albany NY), 2019 Nov 20; 11(22). PMID: 31740624    Free PMC article.
Systematic analysis of gene expression profiles reveals prognostic stratification and underlying mechanisms for muscle-invasive bladder cancer.
Ping-Bao Zhang, Zi-Li Huang, +3 authors, Xiu-Yan Huang.
Cancer Cell Int, 2019 Dec 24; 19. PMID: 31866765    Free PMC article.
Putative biomarkers for predicting tumor sample purity based on gene expression data.
Yuanyuan Li, David M Umbach, +3 authors, Leping Li.
BMC Genomics, 2019 Dec 29; 20(1). PMID: 31881847    Free PMC article.
Prognostic value of immune-related genes in clear cell renal cell carcinoma.
Bangbei Wan, Bo Liu, +2 authors, Cai Lv.
Aging (Albany NY), 2019 Dec 11; 11(23). PMID: 31821170    Free PMC article.
Patterns of immune infiltration in lung adenocarcinoma revealed a prognosis-associated microRNA-mast cells network.
Chunlin Wang, Xi Tang, Jiaojian Wang, Yanhua Xu.
Hum Cell, 2019 Dec 22; 33(1). PMID: 31863291
Screening and Identifying Immune-Related Cells and Genes in the Tumor Microenvironment of Bladder Urothelial Carcinoma: Based on TCGA Database and Bioinformatics.
Jinlong Cao, Xin Yang, +5 authors, Junqiang Tian.
Front Oncol, 2020 Feb 06; 9. PMID: 32010623    Free PMC article.
Multi-dimensional omics characterization in glioblastoma identifies the purity-associated pattern and prognostic gene signatures.
Yi Xiong, Zujian Xiong, +3 authors, Xuejun Li.
Cancer Cell Int, 2020 Feb 06; 20. PMID: 32021566    Free PMC article.
Screening the Cancer Genome Atlas Database for Genes of Prognostic Value in Acute Myeloid Leukemia.
Jie Ni, Yang Wu, +5 authors, Yuxiao Zheng.
Front Oncol, 2020 Feb 11; 9. PMID: 32039005    Free PMC article.
Cancer stemness, intratumoral heterogeneity, and immune response across cancers.
Alex Miranda, Phineas T Hamilton, +7 authors, Brad H Nelson.
Proc Natl Acad Sci U S A, 2019 Apr 19; 116(18). PMID: 30996127    Free PMC article.
Single-Cell Map of Diverse Immune Phenotypes in the Breast Tumor Microenvironment.
Elham Azizi, Ambrose J Carr, +16 authors, Dana Pe'er.
Cell, 2018 Jul 03; 174(5). PMID: 29961579    Free PMC article.
Highly Cited.
The clinical applications of The Cancer Genome Atlas project for bladder cancer.
Chad J Creighton.
Expert Rev Anticancer Ther, 2018 Aug 08; 18(10). PMID: 30081681    Free PMC article.
Review.
Gene landscape and correlation between B-cell infiltration and programmed death ligand 1 expression in lung adenocarcinoma patients from The Cancer Genome Atlas data set.
Kuo-Hao Ho, Chih-Ju Chang, +5 authors, Ku-Chung Chen.
PLoS One, 2018 Dec 07; 13(12). PMID: 30521597    Free PMC article.
Transcriptomic Profiling of the Tumor Microenvironment Reveals Distinct Subgroups of Clear Cell Renal Cell Cancer: Data from a Randomized Phase III Trial.
A Ari Hakimi, Martin H Voss, +15 authors, Robert J Motzer.
Cancer Discov, 2019 Jan 10; 9(4). PMID: 30622105    Free PMC article.
Highly Cited.
Differential immune profiles distinguish the mutational subtypes of gastrointestinal stromal tumor.
Gerardo A Vitiello, Timothy G Bowler, +9 authors, Ronald P DeMatteo.
J Clin Invest, 2019 Feb 15; 129(5). PMID: 30762585    Free PMC article.
Genomic correlates of response to immune checkpoint blockade.
Tanya E Keenan, Kelly P Burke, Eliezer M Van Allen.
Nat Med, 2019 Mar 08; 25(3). PMID: 30842677    Free PMC article.
Highly Cited. Review.
NOTCH Signaling in T-Cell-Mediated Anti-Tumor Immunity and T-Cell-Based Immunotherapies.
Michelle A Kelliher, Justine E Roderick.
Front Immunol, 2019 Apr 11; 9. PMID: 30967879    Free PMC article.
Review.
The tumor microenvironment in renal cell cancer.
James W Mier.
Curr Opin Oncol, 2019 Apr 16; 31(3). PMID: 30985497    Free PMC article.
Review.
Immunogenic neoantigens derived from gene fusions stimulate T cell responses.
Wei Yang, Ken-Wing Lee, +31 authors, Luc G T Morris.
Nat Med, 2019 Apr 24; 25(5). PMID: 31011208    Free PMC article.
Highly Cited.
Tumor‑infiltrating M2 macrophages driven by specific genomic alterations are associated with prognosis in bladder cancer.
Yongping Xue, Liping Tong, +7 authors, Chuanliang Xu.
Oncol Rep, 2019 Jun 25; 42(2). PMID: 31233191    Free PMC article.
Cooperation Between the Inflammation and Coagulation Systems Promotes the Survival of Circulating Tumor Cells in Renal Cell Carcinoma Patients.
Li Wen, Liping Guo, +7 authors, Jianzhong Shou.
Front Oncol, 2019 Jul 03; 9. PMID: 31263677    Free PMC article.
Estimation of immune cell content in tumor using single-cell RNA-seq reference data.
Xiaoqing Yu, Y Ann Chen, +2 authors, Xuefeng Wang.
BMC Cancer, 2019 Jul 22; 19(1). PMID: 31324168    Free PMC article.
HIF-independent synthetic lethality between CDK4/6 inhibition and VHL loss across species.
Hilary E Nicholson, Zeshan Tariq, +5 authors, William G Kaelin.
Sci Signal, 2019 Oct 03; 12(601). PMID: 31575731    Free PMC article.
m6A regulator-mediated methylation modification patterns and tumor microenvironment infiltration characterization in gastric cancer.
Bo Zhang, Qiong Wu, +3 authors, You Lang Zhou.
Mol Cancer, 2020 Mar 14; 19(1). PMID: 32164750    Free PMC article.
Identification of prognostic immune-related genes in the tumor microenvironment of endometrial cancer.
Peigen Chen, Yuebo Yang, +3 authors, Jing Wan.
Aging (Albany NY), 2020 Feb 20; 12(4). PMID: 32074080    Free PMC article.
Analysis of immune-related signatures of lung adenocarcinoma identified two distinct subtypes: implications for immune checkpoint blockade therapy.
Qinghua Wang, Meiling Li, +5 authors, Kexin Chen.
Aging (Albany NY), 2020 Feb 25; 12(4). PMID: 32091408    Free PMC article.
Transcriptomic signatures related to the obesity paradox in patients with clear cell renal cell carcinoma: a cohort study.
Alejandro Sanchez, Helena Furberg, +16 authors, A Ari Hakimi.
Lancet Oncol, 2019 Dec 25; 21(2). PMID: 31870811    Free PMC article.
Immune-related prognosis biomarkers associated with osteosarcoma microenvironment.
Weifeng Hong, Hong Yuan, +5 authors, Liheng Ma.
Cancer Cell Int, 2020 Mar 20; 20. PMID: 32190007    Free PMC article.
Molecular classification of breast cancer using the mRNA expression profiles of immune-related genes.
Juan Mei, Ji Zhao, Yi Fu.
Sci Rep, 2020 Mar 18; 10(1). PMID: 32179831    Free PMC article.
Tumor-Infiltrating T Cells From Clear Cell Renal Cell Carcinoma Patients Recognize Neoepitopes Derived From Point and Frameshift Mutations.
Ulla Kring Hansen, Sofie Ramskov, +10 authors, Sine Reker Hadrup.
Front Immunol, 2020 Apr 01; 11. PMID: 32226429    Free PMC article.
Integrative -omics and HLA-ligandomics analysis to identify novel drug targets for ccRCC immunotherapy.
Anna Reustle, Moreno Di Marco, +19 authors, Elke Schaeffeler.
Genome Med, 2020 Apr 02; 12(1). PMID: 32228647    Free PMC article.
Prognostic value of immune-related genes in the tumor microenvironment of lung adenocarcinoma and lung squamous cell carcinoma.
Yan Qu, Bo Cheng, +4 authors, Jianbo Wang.
Aging (Albany NY), 2020 Mar 27; 12(6). PMID: 32209727    Free PMC article.
Tumor-associated macrophage expression of interferon regulatory Factor-8 (IRF8) is a predictor of progression and patient survival in renal cell carcinoma.
Jason B Muhitch, Nicholas C Hoffend, +5 authors, Scott I Abrams.
J Immunother Cancer, 2019 Jun 22; 7(1). PMID: 31221219    Free PMC article.
High expression of oxidative phosphorylation genes predicts improved survival in squamous cell carcinomas of the head and neck and lung.
Mitchell Frederick, Heath D Skinner, +2 authors, Vlad C Sandulache.
Sci Rep, 2020 Apr 15; 10(1). PMID: 32286489    Free PMC article.
An immune relevant signature for predicting prognoses and immunotherapeutic responses in patients with muscle-invasive bladder cancer (MIBC).
Wen Jiang, Dandan Zhu, Chenghe Wang, Yu Zhu.
Cancer Med, 2020 Feb 26; 9(8). PMID: 32096345    Free PMC article.
Predictive Analyses of Prognostic-Related Immune Genes and Immune Infiltrates for Glioblastoma.
Ping Liang, Yi Chai, He Zhao, Guihuai Wang.
Diagnostics (Basel), 2020 Mar 28; 10(3). PMID: 32214002    Free PMC article.
Screening TCGA database for prognostic genes in lower grade glioma microenvironment.
Jie Ni, Siwen Liu, +4 authors, Yuxiao Zheng.
Ann Transl Med, 2020 Apr 21; 8(5). PMID: 32309356    Free PMC article.
Identification and validation of dichotomous immune subtypes based on intratumoral immune cells infiltration in clear cell renal cell carcinoma patients.
Ying Xiong, Zewei Wang, +15 authors, Jiejie Xu.
J Immunother Cancer, 2020 Mar 29; 8(1). PMID: 32217761    Free PMC article.
The influence of tumour mutational burden on renal cancer immune infiltration and survival.
Matthew H V Byrne, Thomas J Mitchell.
Ann Transl Med, 2020 May 02; 8(6). PMID: 32355715    Free PMC article.
Identification of genes of prognostic value in the ccRCC microenvironment from TCGA database.
Bangbei Wan, Bo Liu, Yuan Huang, Cai Lv.
Mol Genet Genomic Med, 2020 Feb 06; 8(4). PMID: 32012488    Free PMC article.
Characterization of tumor mutation burden, PD-L1 and DNA repair genes to assess relationship to immune checkpoint inhibitors response in metastatic renal cell carcinoma.
Matthew Kyle Labriola, Jason Zhu, +9 authors, Tian Zhang.
J Immunother Cancer, 2020 Mar 30; 8(1). PMID: 32221016    Free PMC article.
Omics-wide quantitative B-cell infiltration analyses identify GPR18 for human cancer prognosis with superiority over CD20.
Yuchen Liu, Li Wang, Kwok-Wai Lo, Vivian Wai Yan Lui.
Commun Biol, 2020 May 14; 3(1). PMID: 32398659    Free PMC article.
CCR5 blockade inflames antitumor immunity in BAP1-mutant clear cell renal cell carcinoma.
Quan Zhou, Yangyang Qi, +17 authors, Jiejie Xu.
J Immunother Cancer, 2020 May 07; 8(1). PMID: 32371459    Free PMC article.
Tumor neoantigenicity assessment with CSiN score incorporates clonality and immunogenicity to predict immunotherapy outcomes.
Tianshi Lu, Shidan Wang, +11 authors, Tao Wang.
Sci Immunol, 2020 Feb 23; 5(44). PMID: 32086382    Free PMC article.
Angiogenesis and Immunity in Renal Carcinoma: Can We Turn an Unhappy Relationship into a Happy Marriage?
Alessia Mennitto, Veronica Huber, +9 authors, Elena Verzoni.
J Clin Med, 2020 Apr 02; 9(4). PMID: 32231117    Free PMC article.
Review.
Immunoscore Predicts Survival in Early-Stage Lung Adenocarcinoma Patients.
Zihuan Zhao, Dan Zhao, +2 authors, Buhai Wang.
Front Oncol, 2020 May 28; 10. PMID: 32457841    Free PMC article.
Exploring immune-related genes with prognostic value in microenvironment of breast cancer from TCGA database.
Hao Yang, Kankan Zhao, +2 authors, Aiguo Wu.
Medicine (Baltimore), 2020 Apr 04; 99(14). PMID: 32243373    Free PMC article.
Systematic Multiomic Analysis of Ly75 Gene Expression and Its Prognostic Value Through the Infiltration of Natural Killer (NK) Cells in Skin Cutaneous Melanoma.
Minchan Gil, Kyung Eun Kim.
J Clin Med, 2020 May 14; 9(5). PMID: 32397120    Free PMC article.
Characteristics, dynamic changes, and prognostic significance of TCR repertoire profiling in patients with renal cell carcinoma.
Liping Guo, Xingang Bi, +7 authors, Jianzhong Shou.
J Pathol, 2020 Feb 20; 251(1). PMID: 32073142    Free PMC article.
Identification of an immune-related long non-coding RNA signature and nomogram as prognostic target for muscle-invasive bladder cancer.
Yuxuan Song, Donghui Jin, +4 authors, Xiaoqiang Liu.
Aging (Albany NY), 2020 Jun 25; 12(12). PMID: 32579540    Free PMC article.
Comprehensive Genomic Analysis of Translocation Renal Cell Carcinoma Reveals Copy-Number Variations as Drivers of Disease Progression.
Julian Marcon, Renzo G DiNatale, +20 authors, Ed Reznik.
Clin Cancer Res, 2020 Mar 30; 26(14). PMID: 32220885    Free PMC article.
Pan-Cancer Analysis of Immune Cell Infiltration Identifies a Prognostic Immune-Cell Characteristic Score (ICCS) in Lung Adenocarcinoma.
Shuguang Zuo, Min Wei, +2 authors, Jiwu Wei.
Front Immunol, 2020 Jul 28; 11. PMID: 32714316    Free PMC article.
A DNA Methylation-Based Panel for the Prognosis and Dagnosis of Patients With Breast Cancer and Its Mechanisms.
Xiao-Ping Liu, Jinxuan Hou, +3 authors, Sheng Li.
Front Mol Biosci, 2020 Aug 01; 7. PMID: 32733914    Free PMC article.
Immune landscapes predict chemotherapy resistance and immunotherapy response in acute myeloid leukemia.
Jayakumar Vadakekolathu, Mark D Minden, +26 authors, Sergio Rutella.
Sci Transl Med, 2020 Jun 05; 12(546). PMID: 32493790    Free PMC article.
HIF-1α and HIF-2α differently regulate tumour development and inflammation of clear cell renal cell carcinoma in mice.
Rouven Hoefflin, Sabine Harlander, +22 authors, Ian J Frew.
Nat Commun, 2020 Aug 19; 11(1). PMID: 32807776    Free PMC article.
Prognostic value and immune infiltration of novel signatures in clear cell renal cell carcinoma microenvironment.
Wen-Hao Xu, Yue Xu, +7 authors, Ding-Wei Ye.
Aging (Albany NY), 2019 Sep 08; 11(17). PMID: 31493764    Free PMC article.
Highly Cited.
Identification of 12 immune-related lncRNAs and molecular subtypes for the clear cell renal cell carcinoma based on RNA sequencing data.
Weimin Zhong, Bin Chen, +7 authors, Jiyi Huang.
Sci Rep, 2020 Sep 04; 10(1). PMID: 32879362    Free PMC article.
Predictive Biomarkers of Response to Immunotherapy in Metastatic Renal Cell Cancer.
Alessandra Raimondi, Pierangela Sepe, +7 authors, Giuseppe Procopio.
Front Oncol, 2020 Sep 10; 10. PMID: 32903369    Free PMC article.
Review.
CCND1 Amplification Contributes to Immunosuppression and Is Associated With a Poor Prognosis to Immune Checkpoint Inhibitors in Solid Tumors.
Yu Chen, Yingying Huang, +13 authors, Chuanben Chen.
Front Immunol, 2020 Sep 10; 11. PMID: 32903763    Free PMC article.
APOBEC mutagenesis is tightly linked to the immune landscape and immunotherapy biomarkers in head and neck squamous cell carcinoma.
Daniel L Faden, Fei Ding, +5 authors, Robert L Ferris.
Oral Oncol, 2019 Aug 20; 96. PMID: 31422205    Free PMC article.
Identification of tumor-infiltrating immune cells and prognostic validation of tumor-infiltrating mast cells in adrenocortical carcinoma: results from bioinformatics and real-world data.
Xi Tian, Wenhao Xu, +10 authors, Dingwei Ye.
Oncoimmunology, 2020 Sep 15; 9(1). PMID: 32923148    Free PMC article.
Classification of Muscle-Invasive Bladder Cancer Based on Immunogenomic Profiling.
Xianghong Zhou, Shi Qiu, +5 authors, Qiang Wei.
Front Oncol, 2020 Sep 26; 10. PMID: 32974156    Free PMC article.
Long Non-Coding RNA Profile Study Identifies an Immune-Related lncRNA Prognostic Signature for Kidney Renal Clear Cell Carcinoma.
Zhuolun Sun, Changying Jing, Chutian Xiao, Tengcheng Li.
Front Oncol, 2020 Sep 26; 10. PMID: 32974157    Free PMC article.
Identifying Cancer Driver lncRNAs Bridged by Functional Effectors through Integrating Multi-omics Data in Human Cancers.
Yong Zhang, Gaoming Liao, +9 authors, Xia Li.
Mol Ther Nucleic Acids, 2019 Jul 16; 17. PMID: 31302496    Free PMC article.
Transcriptomic characterization and innovative molecular classification of clear cell renal cell carcinoma in the Chinese population.
Qiang Zhao, Jia Xue, +10 authors, Ning Zhang.
Cancer Cell Int, 2020 Sep 29; 20. PMID: 32982583    Free PMC article.
Anti-PD-1 Immunotherapy and Radiotherapy for Stage IV Intrahepatic Cholangiocarcinoma: A Case Report.
Ze-Long Liu, Xin Liu, +6 authors, Ming Kuang.
Front Med (Lausanne), 2020 Sep 29; 7. PMID: 32984358    Free PMC article.
Identification of Immune-Related Cells and Genes in Tumor Microenvironment of Clear Cell Renal Cell Carcinoma.
Bowen Du, Yulin Zhou, +10 authors, Wenquan Zhou.
Front Oncol, 2020 Oct 06; 10. PMID: 33014871    Free PMC article.
Assessment for prognostic value of differentially expressed genes in immune microenvironment of clear cell renal cell carcinoma.
Xiaoxue Yin, Xingming Zhang, +11 authors, Hao Zeng.
Am J Transl Res, 2020 Oct 13; 12(9). PMID: 33042428    Free PMC article.
Identification and validation of the prognostic value of immune-related genes in non-small cell lung cancer.
Rui Li, Xiao Liu, +4 authors, Yi-Qing Qu.
Am J Transl Res, 2020 Oct 13; 12(9). PMID: 33042464    Free PMC article.
A Molecular Subtype Model for Liver HBV-Related Hepatocellular Carcinoma Patients Based on Immune-Related Genes.
Qiyao Zhang, Xiao Yu, +2 authors, Wenzhi Guo.
Front Oncol, 2020 Oct 20; 10. PMID: 33072587    Free PMC article.
Mutations in the notch signalling pathway are associated with enhanced anti-tumour immunity in colorectal cancer.
Fei Wang, Jie Long, +10 authors, Jie Cao.
J Cell Mol Med, 2020 Sep 15; 24(20). PMID: 32924269    Free PMC article.
Construction of a 13-Gene Signature as a Novel Prognostic Marker for Patients with Clear Cell Renal Cell Carcinoma and the Role of XCR1 in Cell Proliferation.
Baoying Yuan, Feifei Li, Youbao Li, Yuhan Chen.
Cancer Manag Res, 2020 Oct 30; 12. PMID: 33116819    Free PMC article.
Prognosis Analysis and Validation of m6A Signature and Tumor Immune Microenvironment in Glioma.
Shaojian Lin, Houshi Xu, +5 authors, Meiqing Lou.
Front Oncol, 2020 Oct 31; 10. PMID: 33123464    Free PMC article.
Molecular correlates of cisplatin-based chemotherapy response in muscle invasive bladder cancer by integrated multi-omics analysis.
Ann Taber, Emil Christensen, +11 authors, Lars Dyrskjøt.
Nat Commun, 2020 Sep 27; 11(1). PMID: 32978382    Free PMC article.
High expression levels of DEF6 predicts a poor prognosis for patients with clear cell renal cell carcinoma.
Zhen-Peng Zhu, Lan-Ruo Lin, +3 authors, Jian Lin.
Oncol Rep, 2020 Oct 02; 44(5). PMID: 33000227    Free PMC article.
Functional and Clinical Characterization of Tumor-Infiltrating T Cell Subpopulations in Hepatocellular Carcinoma.
Jianguo Li, Jin Zhou, +3 authors, Jiying Jiang.
Front Genet, 2020 Nov 03; 11. PMID: 33133170    Free PMC article.
DNA Methylation-Based Panel Predicts Survival of Patients With Clear Cell Renal Cell Carcinoma and Its Correlations With Genomic Metrics and Tumor Immune Cell Infiltration.
Xiao-Ping Liu, Lingao Ju, +3 authors, Xinghuan Wang.
Front Cell Dev Biol, 2020 Nov 13; 8. PMID: 33178689    Free PMC article.
Proteomic analysis of hypopharyngeal and laryngeal squamous cell carcinoma sheds light on differences in survival.
Jiajia Liu, Weiming Zhu, +5 authors, Gangcai Zhu.
Sci Rep, 2020 Nov 12; 10(1). PMID: 33173143    Free PMC article.
A novel scoring method based on RNA-Seq immunograms describing individual cancer-immunity interactions.
Yukari Kobayashi, Yoshihiro Kushihara, +2 authors, Kazuhiro Kakimi.
Cancer Sci, 2020 Aug 19; 111(11). PMID: 32810311    Free PMC article.
Neoangiogenesis in Melanoma: An Issue in Biology and Systemic Treatment.
Davide Quaresmini, Michele Guida.
Front Immunol, 2020 Nov 17; 11. PMID: 33193402    Free PMC article.
Review.
A 14 immune-related gene signature predicts clinical outcomes of kidney renal clear cell carcinoma.
Yong Zou, Chuan Hu.
PeerJ, 2020 Nov 17; 8. PMID: 33194402    Free PMC article.
High-dimensional Cytometry (ExCYT) and Mass Spectrometry of Myeloid Infiltrate in Clinically Localized Clear Cell Renal Cell Carcinoma Identifies Novel Potential Myeloid Targets for Immunotherapy.
Debebe Theodros, Benjamin M Murter, +12 authors, Jelani C Zarif.
Mol Cell Proteomics, 2020 Aug 02; 19(11). PMID: 32737216    Free PMC article.
Immunotherapeutic Targets and Therapy for Renal Cell Carcinoma.
Pierangela Sepe, Alessia Mennitto, Francesca Corti, Giuseppe Procopio.
Immunotargets Ther, 2020 Nov 24; 9. PMID: 33224904    Free PMC article.
Review.
Characterization of the Immune Cell Infiltration Landscape in Head and Neck Squamous Cell Carcinoma to Aid Immunotherapy.
Xinhai Zhang, Mengqi Shi, Tielou Chen, Boxin Zhang.
Mol Ther Nucleic Acids, 2020 Nov 25; 22. PMID: 33230435    Free PMC article.
Local mutational diversity drives intratumoral immune heterogeneity in non-small cell lung cancer.
Qingzhu Jia, Wei Wu, +15 authors, Bo Zhu.
Nat Commun, 2018 Dec 19; 9(1). PMID: 30560866    Free PMC article.
Highly Cited.
A high-risk luminal A dominant breast cancer subtype with increased mobility.
Liping Guo, Guoji Chen, +6 authors, Kaitai Zhang.
Breast Cancer Res Treat, 2019 Feb 20; 175(2). PMID: 30778902    Free PMC article.
Immunomodulatory and immunotherapeutic implications of tobacco smoking in squamous cell carcinomas and normal airway epithelium.
Jingming Wang, Maximilian Linxweiler, +2 authors, Luc G T Morris.
Oncotarget, 2019 Jun 25; 10(39). PMID: 31231463    Free PMC article.
An elastic-net logistic regression approach to generate classifiers and gene signatures for types of immune cells and T helper cell subsets.
Arezo Torang, Paraag Gupta, David J Klinke.
BMC Bioinformatics, 2019 Aug 24; 20(1). PMID: 31438843    Free PMC article.
Tumor genotype, location, and malignant potential shape the immunogenicity of primary untreated gastrointestinal stromal tumors.
Daniela Gasparotto, Marta Sbaraglia, +8 authors, Roberta Maestro.
JCI Insight, 2020 Oct 14; 5(22). PMID: 33048845    Free PMC article.
B cells, plasma cells and antibody repertoires in the tumour microenvironment.
George V Sharonov, Ekaterina O Serebrovskaya, +2 authors, Dmitriy M Chudakov.
Nat Rev Immunol, 2020 Jan 29; 20(5). PMID: 31988391
Review.
Characterizing heterogeneity of non-small cell lung tumour microenvironment to identify signature prognostic genes.
Kai Mi, Fuhui Chen, +8 authors, Desi Shang.
J Cell Mol Med, 2020 Nov 14; 24(24). PMID: 33184998    Free PMC article.
Features of increased malignancy in eosinophilic clear cell renal cell carcinoma.
Helén Nilsson, David Lindgren, +4 authors, Martin E Johansson.
J Pathol, 2020 Aug 21; 252(4). PMID: 32815150    Free PMC article.
Heterogeneous Tumor-Immune Microenvironments between Primary and Metastatic Tumors in a Patient with ALK Rearrangement-Positive Large Cell Neuroendocrine Carcinoma.
Takahiro Tashiro, Kosuke Imamura, +10 authors, Takuro Sakagami.
Int J Mol Sci, 2020 Dec 24; 21(24). PMID: 33352665    Free PMC article.
Interaction network of immune-associated genes affecting the prognosis of patients with glioblastoma.
Xiaohong Hou, Jialin Chen, +5 authors, Shengtao Yao.
Exp Ther Med, 2020 Dec 29; 21(1). PMID: 33365061    Free PMC article.
Development and validation of a VHL-associated immune prognostic signature for clear cell renal cell carcinoma.
Jin Zhang, Aiting Yan, +3 authors, Xiaowu Liu.
Cancer Cell Int, 2020 Dec 30; 20(1). PMID: 33372609    Free PMC article.
Identification of Driver Genes Regulating the T-Cell-Infiltrating Levels in Hepatocellular Carcinoma.
Yi Cai, Ying Tian, +8 authors, Zhengxia Yang.
Front Genet, 2021 Jan 01; 11. PMID: 33381145    Free PMC article.
Identification of the Prognostic Value of Tumor Microenvironment-Related Genes in Esophageal Squamous Cell Carcinoma.
Donglei Zhang, Changlin Qian, Huabing Wei, Xiaozhe Qian.
Front Mol Biosci, 2021 Jan 01; 7. PMID: 33381521    Free PMC article.
Identification and Verification of Immune-Related Gene Prognostic Signature Based on ssGSEA for Osteosarcoma.
Bo Xiao, Liyan Liu, +4 authors, Tao Xiao.
Front Oncol, 2021 Jan 02; 10. PMID: 33384961    Free PMC article.
ACE2 Correlated With Immune Infiltration Serves As A Novel Prognostic Biomarker In Clear Cell Renal Cell Carcinoma: Implication For COVID-19.
Wuping Yang, Lei Li, +5 authors, Kan Gong.
Int J Biol Sci, 2021 Jan 05; 17(1). PMID: 33390830    Free PMC article.
Clonal architectures predict clinical outcome in clear cell renal cell carcinoma.
Yi Huang, Jiayin Wang, +9 authors, Baifeng Zhang.
Nat Commun, 2019 Mar 20; 10(1). PMID: 30886153    Free PMC article.
Decoding Immune Heterogeneity of Melanoma and identifying immune-prognostic hub genes.
Yu Zhang, Siyu Hao, +2 authors, Yuzhen Li.
J Cancer, 2021 Jan 07; 12(3). PMID: 33403028    Free PMC article.
Transcriptome Analysis of Ovarian and Uterine Clear Cell Malignancies.
Jill Alldredge, Leslie Randall, +7 authors, Farah Rahmatpanah.
Front Oncol, 2021 Jan 09; 10. PMID: 33415077    Free PMC article.
A Prognostic Microenvironment-Related Immune Signature via ESTIMATE (PROMISE Model) Predicts Overall Survival of Patients With Glioma.
Huaide Qiu, Yongqiang Li, +3 authors, Jianan Li.
Front Oncol, 2021 Jan 12; 10. PMID: 33425732    Free PMC article.
Beyond conventional immune-checkpoint inhibition - novel immunotherapies for renal cell carcinoma.
David A Braun, Ziad Bakouny, +4 authors, Toni K Choueiri.
Nat Rev Clin Oncol, 2021 Jan 14; 18(4). PMID: 33437048    Free PMC article.
Review.
Upregulation of KIF20A promotes tumor proliferation and invasion in renal clear cell carcinoma and is associated with adverse clinical outcome.
Xiaohan Ren, Xinglin Chen, +4 authors, Kai Fang.
Aging (Albany NY), 2020 Nov 25; 12(24). PMID: 33232285    Free PMC article.
The long noncoding RNA LINC01140/miR-140-5p/FGF9 axis modulates bladder cancer cell aggressiveness and macrophage M2 polarization.
Shuiqing Wu, Ran Xu, +5 authors, Xiaokun Zhao.
Aging (Albany NY), 2020 Nov 26; 12(24). PMID: 33234721    Free PMC article.
Tumor Microenvironment Features as Predictive Biomarkers of Response to Immune Checkpoint Inhibitors (ICI) in Metastatic Clear Cell Renal Cell Carcinoma (mccRCC).
Audrey Simonaggio, Nicolas Epaillard, +3 authors, Yann-Alexandre Vano.
Cancers (Basel), 2021 Jan 14; 13(2). PMID: 33435262    Free PMC article.
Review.
Mapping the immune environment in clear cell renal carcinoma by single-cell genomics.
Nicholas Borcherding, Ajaykumar Vishwakarma, +7 authors, Weizhou Zhang.
Commun Biol, 2021 Jan 29; 4(1). PMID: 33504936    Free PMC article.
SLAMF7 Signaling Reprograms T Cells toward Exhaustion in the Tumor Microenvironment.
Patrick O'Connell, Sean Hyslop, +3 authors, Yasser A Aldhamen.
J Immunol, 2020 Dec 09; 206(1). PMID: 33288545    Free PMC article.
Novel roles of VAT1 expression in the immunosuppressive action of diffuse gliomas.
Pei Yang, Kuanyu Wang, +5 authors, Xia Shan.
Cancer Immunol Immunother, 2021 Feb 13; 70(9). PMID: 33576871
Immunotherapy for advanced thyroid cancers - rationale, current advances and future strategies.
Jena D French.
Nat Rev Endocrinol, 2020 Aug 26; 16(11). PMID: 32839578
Review.
Construction of co-expression modules related to survival by WGCNA and identification of potential prognostic biomarkers in glioblastoma.
Jing Zhou, Hao Guo, +6 authors, Weiwei Zhang.
J Cell Mol Med, 2021 Jan 16; 25(3). PMID: 33449451    Free PMC article.
The immune-related biomarker TEK inhibits the development of clear cell renal cell carcinoma (ccRCC) by regulating AKT phosphorylation.
Siming Chen, Mengxue Yu, +4 authors, Xinghuan Wang.
Cancer Cell Int, 2021 Feb 20; 21(1). PMID: 33602230    Free PMC article.
Development of prognostic signature based on immune-related genes in muscle-invasive bladder cancer: bioinformatics analysis of TCGA database.
Kun Jin, Shi Qiu, +6 authors, Qiang Wei.
Aging (Albany NY), 2021 Jan 20; 13(2). PMID: 33465047    Free PMC article.
Comprehensive Analysis of the Immune Infiltrates and Aberrant Pathways Activation in Atherosclerotic Plaque.
Hukui Han, Rongsheng Du, +3 authors, Gang Li.
Front Cardiovasc Med, 2021 Feb 23; 7. PMID: 33614738    Free PMC article.
m6A modification patterns and tumor immune landscape in clear cell renal carcinoma.
Jiehui Zhong, Zezhen Liu, +3 authors, Guohua Zeng.
J Immunother Cancer, 2021 Feb 13; 9(2). PMID: 33574053    Free PMC article.
Glycolysis-associated lncRNAs identify a subgroup of cancer patients with poor prognoses and a high-infiltration immune microenvironment.
Kuo-Hao Ho, Tzu-Wen Huang, +4 authors, Ku-Chung Chen.
BMC Med, 2021 Feb 26; 19(1). PMID: 33627136    Free PMC article.
The Immune Microenvironment and Neoantigen Landscape of Aggressive Salivary Gland Carcinomas Differ by Subtype.
Maximilian Linxweiler, Fengshen Kuo, +13 authors, Luc G T Morris.
Clin Cancer Res, 2020 Feb 16; 26(12). PMID: 32060100    Free PMC article.
Transcriptomic characterization reveals prognostic molecular signatures of sorafenib resistance in hepatocellular carcinoma.
Wei Yuan, Ran Tao, +3 authors, Qin Ning.
Aging (Albany NY), 2021 Jan 27; 13(3). PMID: 33495404    Free PMC article.
Immune Infiltration Landscape in Clear Cell Renal Cell Carcinoma Implications.
Yongfeng Wang, Ci Yin, Lele Geng, Weiyang Cai.
Front Oncol, 2021 Mar 06; 10. PMID: 33665156    Free PMC article.
The Gene Expression Deconvolution Interactive Tool (GEDIT): accurate cell type quantification from gene expression data.
Brian B Nadel, David Lopez, +5 authors, Matteo Pellegrini.
Gigascience, 2021 Feb 17; 10(2). PMID: 33590863    Free PMC article.
The association of sex-biased ATRX mutation in female gastric cancer patients with enhanced immunotherapy-related anticancer immunity.
You Ge, Feiran Wei, +5 authors, Pingmin Wei.
BMC Cancer, 2021 Mar 09; 21(1). PMID: 33678158    Free PMC article.
Clear cell renal cell carcinoma ontogeny and mechanisms of lethality.
Eric Jonasch, Cheryl Lyn Walker, W Kimryn Rathmell.
Nat Rev Nephrol, 2020 Nov 05; 17(4). PMID: 33144689    Free PMC article.
Review.
Roles of the Dynamic Tumor Immune Microenvironment in the Individualized Treatment of Advanced Clear Cell Renal Cell Carcinoma.
Enyu Lin, Xuechao Liu, +5 authors, Yuming Yu.
Front Immunol, 2021 Mar 23; 12. PMID: 33746989    Free PMC article.
Review.
Promises and challenges of adoptive T-cell therapies for solid tumours.
Matteo Morotti, Ashwag Albukhari, +18 authors, Ahmed A Ahmed.
Br J Cancer, 2021 Mar 31; 124(11). PMID: 33782566    Free PMC article.
Review.
Global Characterization of Immune Infiltration in Clear Cell Renal Cell Carcinoma.
Yan Zheng, Yibo Wen, +6 authors, Fengmin Shao.
Onco Targets Ther, 2021 Apr 02; 14. PMID: 33790572    Free PMC article.
Immune Cell Infiltration-Based Characterization of Triple-Negative Breast Cancer Predicts Prognosis and Chemotherapy Response Markers.
Yufei Lv, Dongxu Lv, +3 authors, Yafang Zhang.
Front Genet, 2021 Apr 06; 12. PMID: 33815462    Free PMC article.
Abundance of Microvascular Endothelial Cells Is Associated with Response to Chemotherapy and Prognosis in Colorectal Cancer.
Masanori Oshi, Michelle R Huyser, +5 authors, Kazuaki Takabe.
Cancers (Basel), 2021 Apr 04; 13(6). PMID: 33807015    Free PMC article.
Investigating T Cell Immunity in Cancer: Achievements and Prospects.
Zhen Zeng, Hui Yi Chew, +2 authors, James W Wells.
Int J Mol Sci, 2021 Apr 04; 22(6). PMID: 33809369    Free PMC article.
Review.
Mutations in BRCA1 and BRCA2 differentially affect the tumor microenvironment and response to checkpoint blockade immunotherapy.
Robert M Samstein, Chirag Krishna, +25 authors, Nadeem Riaz.
Nat Cancer, 2021 Apr 10; 1(12). PMID: 33834176    Free PMC article.
An integrated multi-omics analysis identifies prognostic molecular subtypes of non-muscle-invasive bladder cancer.
Sia Viborg Lindskrog, Frederik Prip, +44 authors, Lars Dyrskjøt.
Nat Commun, 2021 Apr 18; 12(1). PMID: 33863885    Free PMC article.
Identification of Inflammatory Genes, Pathways, and Immune Cells in Necrotizing Enterocolitis of Preterm Infant by Bioinformatics Approaches.
Lili Zhang, Lizhen Sun, Mingli Wu, Jie Huang.
Biomed Res Int, 2021 Apr 22; 2021. PMID: 33880370    Free PMC article.
RB1 and TP53 co-mutations correlate strongly with genomic biomarkers of response to immunity checkpoint inhibitors in urothelial bladder cancer.
Ramon Gonzalez Manzano, Ana Catalan-Latorre, Antonio Brugarolas.
BMC Cancer, 2021 Apr 22; 21(1). PMID: 33879103    Free PMC article.
Comprehensive description of the current breast cancer microenvironment advancements via single-cell analysis.
Xueqi Yan, Yinghong Xie, +10 authors, Yongmei Yin.
J Exp Clin Cancer Res, 2021 Apr 29; 40(1). PMID: 33906694    Free PMC article.
Review.
Systematic Assessment of Transcriptomic Biomarkers for Immune Checkpoint Blockade Response in Cancer Immunotherapy.
Shangqin Sun, Liwen Xu, +8 authors, Yun Xiao.
Cancers (Basel), 2021 May 01; 13(7). PMID: 33915876    Free PMC article.
Systematic Chromatin Accessibility Analysis Based on Different Immunological Subtypes of Clear Cell Renal Cell Carcinoma.
Shiqiang Zhang, Wenzhong Zheng, +11 authors, Jun Pang.
Front Oncol, 2021 May 04; 11. PMID: 33937014    Free PMC article.
Identification of immune-related genes with prognostic significance in the microenvironment of cutaneous melanoma.
Yan Qu, Shuqing Zhang, +2 authors, Fengjuan Wang.
Virchows Arch, 2020 Nov 13; 478(5). PMID: 33179141
Pathological Findings of the Host Immune Reaction in the Tumor Microenvironment of Gastroenteropancreatic Neuroendocrine Neoplasms.
Sho Hasegawa, Noritoshi Kobayashi, +8 authors, Yasushi Ichikawa.
Intern Med, 2020 Nov 10; 60(7). PMID: 33162477    Free PMC article.
Seven-gene signature on tumor microenvironment for predicting the prognosis of patients with pancreatic cancer.
Bin Yang, Jinghua Xie, +6 authors, Yanan Lu.
Gland Surg, 2021 May 11; 10(4). PMID: 33968691    Free PMC article.
The Immune-Related Gene HCST as a Novel Biomarker for the Diagnosis and Prognosis of Clear Cell Renal Cell Carcinoma.
Yongying Zhou, Xiao Wang, +13 authors, Xinhua Zhang.
Front Oncol, 2021 May 11; 11. PMID: 33968730    Free PMC article.
Metastatic Renal Cell Carcinoma Management: From Molecular Mechanism to Clinical Practice.
Michela Roberto, Andrea Botticelli, +9 authors, Paolo Marchetti.
Front Oncol, 2021 May 11; 11. PMID: 33968762    Free PMC article.
Review.
Current and Prospective Methods for Assessing Anti-Tumor Immunity in Colorectal Cancer.
Yulia I Nussbaum, Yariswamy Manjunath, +5 authors, Jonathan B Mitchem.
Int J Mol Sci, 2021 May 06; 22(9). PMID: 33946558    Free PMC article.
Review.
Immunology and Immunotherapeutic Approaches for Advanced Renal Cell Carcinoma: A Comprehensive Review.
Yoon-Soo Hah, Kyo-Chul Koo.
Int J Mol Sci, 2021 May 01; 22(9). PMID: 33923219    Free PMC article.
Review.
Tumor and immune reprogramming during immunotherapy in advanced renal cell carcinoma.
Kevin Bi, Meng Xiao He, +27 authors, Eliezer M Van Allen.
Cancer Cell, 2021 Mar 13; 39(5). PMID: 33711272    Free PMC article.
Progressive immune dysfunction with advancing disease stage in renal cell carcinoma.
David A Braun, Kelly Street, +32 authors, Catherine J Wu.
Cancer Cell, 2021 Mar 13; 39(5). PMID: 33711273    Free PMC article.
Identification of immune subtypes of cervical squamous cell carcinoma predicting prognosis and immunotherapy responses.
Yimin Li, Shun Lu, +2 authors, Jinyi Lang.
J Transl Med, 2021 May 26; 19(1). PMID: 34030694    Free PMC article.
ADAMTS12 acts as a tumor microenvironment related cancer promoter in gastric cancer.
Yangming Hou, Yingjuan Xu, Dequan Wu.
Sci Rep, 2021 May 28; 11(1). PMID: 34040054    Free PMC article.
Identification of a Prognostic Signature for Ovarian Cancer Based on the Microenvironment Genes.
Xiao Huo, Hengzi Sun, +4 authors, Shuhong Li.
Front Genet, 2021 Jun 01; 12. PMID: 34054929    Free PMC article.
Characterization of the Immune Cell Infiltration Profile in Pancreatic Carcinoma to Aid in Immunotherapy.
De Luo, Fei Kuang, +7 authors, Song Su.
Front Oncol, 2021 Jun 01; 11. PMID: 34055645    Free PMC article.
Development of an Immune-Related Prognostic Index Associated With Glioblastoma.
Zhengye Jiang, Yanxi Shi, +5 authors, Zhanxiang Wang.
Front Neurol, 2021 Jun 08; 12. PMID: 34093386    Free PMC article.
Accumulation of CD45RO+CD8+ T cells is a diagnostic and prognostic biomarker for clear cell renal cell carcinoma.
Ke Wu, Xinyi Zheng, +6 authors, Junhua Zheng.
Aging (Albany NY), 2021 May 22; 13(10). PMID: 34016791    Free PMC article.
Current status of antigen-specific T-cell immunotherapy for advanced renal-cell carcinoma.
Yuexin Xu, Chris P Miller, Edus H Warren, Scott S Tykodi.
Hum Vaccin Immunother, 2021 Mar 06; 17(7). PMID: 33667140    Free PMC article.
Review.
The platelet to lymphocyte ratio predicts overall survival better than the neutrophil to lymphocyte ratio in metastatic renal cell carcinoma
Oktay Halit Aktepe, Gürkan Güner, +5 authors, Mustafa Erman.
Turk J Med Sci, 2020 Dec 23; 51(2). PMID: 33350295    Free PMC article.
The Tumor Microenvironment of Bladder Cancer.
Ken Hatogai, Randy F Sweis.
Adv Exp Med Biol, 2020 Jan 01; 1296. PMID: 34185299    Free PMC article.
Integrated transcriptional-phenotypic analysis captures systemic immunomodulation following antiangiogenic therapy in renal cell carcinoma patients.
Darawan Rinchai, Elena Verzoni, +15 authors, Licia Rivoltini.
Clin Transl Med, 2021 Jun 30; 11(6). PMID: 34185403    Free PMC article.
Single-cell sequencing links multiregional immune landscapes and tissue-resident T cells in ccRCC to tumor topology and therapy efficacy.
Chirag Krishna, Renzo G DiNatale, +30 authors, A Ari Hakimi.
Cancer Cell, 2021 Apr 17; 39(5). PMID: 33861994    Free PMC article.
Radiomics Analysis of Contrast-Enhanced CT Predicts Survival in Clear Cell Renal Cell Carcinoma.
Lei Yan, Guangjie Yang, +8 authors, Zhenguang Wang.
Front Oncol, 2021 Jul 13; 11. PMID: 34249712    Free PMC article.
Characterization of Hypoxia-Related Molecular Subtypes in Clear Cell Renal Cell Carcinoma to Aid Immunotherapy and Targeted Therapy via Multi-Omics Analysis.
Weimin Zhong, Hongbin Zhong, +3 authors, Jiyi Huang.
Front Mol Biosci, 2021 Jul 13; 8. PMID: 34250018    Free PMC article.
Associations between T cell infiltration, T cell receptor clonality, histology and recurrence in renal cell carcinoma.
Moran Gadot, Mordechay Gal, +6 authors, Raya Leibowitz.
Clin Exp Immunol, 2021 Apr 27; 205(2). PMID: 33899933    Free PMC article.
Identification of Prognostic miRNAs Associated With Immune Cell Tumor Infiltration Predictive of Clinical Outcomes in Patients With Non-Small Cell Lung Cancer.
Yuepeng Zhang, Kai Mi, +5 authors, Shoude Jin.
Front Oncol, 2021 Jul 20; 11. PMID: 34277450    Free PMC article.
m6A Regulator-Associated Modification Patterns and Immune Infiltration of the Tumor Microenvironment in Hepatocarcinoma.
Jianhao Li, Weiwei Wang, +8 authors, Ranran Sun.
Front Cell Dev Biol, 2021 Jul 20; 9. PMID: 34277630    Free PMC article.
A novel ferroptosis-related 12-gene signature predicts clinical prognosis and reveals immune relevancy in clear cell renal cell carcinoma.
Yingkai Hong, Mingen Lin, +2 authors, Peilin Shen.
BMC Cancer, 2021 Jul 21; 21(1). PMID: 34281531    Free PMC article.
CD3+, CD8+, CD4+ and FOXP3+ T Cells in the Immune Microenvironment of Small Bowel Neuroendocrine Tumors.
Niko Hiltunen, Juha P Väyrynen, Jan Böhm, Olli Helminen.
Diseases, 2021 Jul 03; 9(2). PMID: 34208144    Free PMC article.
A review of digital cytometry methods: estimating the relative abundance of cell types in a bulk of cells.
Trang Le, Rachel A Aronow, Arkadz Kirshtein, Leili Shahriyari.
Brief Bioinform, 2020 Oct 02; 22(4). PMID: 33003193    Free PMC article.
Review.
Development and Validation of a Radiomic Nomogram for Predicting the Prognosis of Kidney Renal Clear Cell Carcinoma.
Ruizhi Gao, Hui Qin, +13 authors, Hong Yang.
Front Oncol, 2021 Jul 24; 11. PMID: 34295804    Free PMC article.
Effect of Immune Cell Infiltration on Occurrence of Pulmonary Hypertension in Pulmonary Fibrosis Patients Based on Gene Expression Profiles.
Feng Zhu, Lili Zuo, +4 authors, Limin Feng.
Front Med (Lausanne), 2021 Jul 27; 8. PMID: 34307406    Free PMC article.
Exosomes derived from mesenchymal stem cells curbs the progression of clear cell renal cell carcinoma through T-cell immune response.
Daoyuan Li, Feifei Lin, Guoping Li, Fanchang Zeng.
Cytotechnology, 2021 Aug 06; 73(4). PMID: 34349349    Free PMC article.
Prognostic Implications of Immune-Related Gene Pairs Signatures in Bladder Cancer.
Hui Xiong, Hui Gao, +9 authors, Weiting Kang.
J Oncol, 2021 Aug 07; 2021. PMID: 34354750    Free PMC article.
Identification of prognostic immune-related gene signature associated with tumor microenvironment of colorectal cancer.
Yuanyuan Wang, Wei Li, +7 authors, Xiaosong Gu.
BMC Cancer, 2021 Aug 09; 21(1). PMID: 34364366    Free PMC article.
Immune infiltration phenotypes of prostate adenocarcinoma and their clinical implications.
Zehua Ma, Xiankui Cheng, +6 authors, Wei Xue.
Cancer Med, 2021 Jun 16; 10(15). PMID: 34128342    Free PMC article.
Identification of Somatic Mutation-Driven Immune Cells by Integrating Genomic and Transcriptome Data.
Ying Jiang, Baotong Zheng, +2 authors, Junwei Han.
Front Cell Dev Biol, 2021 Aug 10; 9. PMID: 34368166    Free PMC article.
Immune checkpoint blockade in renal cell carcinoma.
Phillip M Rappold, Andrew W Silagy, Ritesh R Kotecha, Ari A Hakimi.
J Surg Oncol, 2021 Feb 18; 123(3). PMID: 33595892    Free PMC article.
Review.
The Identification of Zinc-Finger Protein 433 as a Possible Prognostic Biomarker for Clear-Cell Renal Cell Carcinoma.
Simone O Heyliger, Karam F A Soliman, Marilyn D Saulsbury, Romonia Renee Reams.
Biomolecules, 2021 Aug 28; 11(8). PMID: 34439859    Free PMC article.
Gene Model Related to m6A Predicts the Prognostic Effect of Immune Infiltration on Head and Neck Squamous Cell Carcinoma.
Yaping Deng, Kehua Li, Fengwu Tan, Hanbo Liu.
J Oncol, 2021 Aug 31; 2021. PMID: 34457003    Free PMC article.
Integrated exome and RNA sequencing of TFE3-translocation renal cell carcinoma.
Guangxi Sun, Junru Chen, +33 authors, Hao Zeng.
Nat Commun, 2021 Sep 08; 12(1). PMID: 34489456    Free PMC article.
Molecular Subsets in Renal Cancer Determine Outcome to Checkpoint and Angiogenesis Blockade.
Robert J Motzer, Romain Banchereau, +19 authors, Brian Rini.
Cancer Cell, 2020 Nov 07; 38(6). PMID: 33157048    Free PMC article.
YTHDF2 is a Potential Biomarker and Associated with Immune Infiltration in Kidney Renal Clear Cell Carcinoma.
Ganglin Su, Tianshu Liu, +8 authors, Hongbing Mei.
Front Pharmacol, 2021 Sep 14; 12. PMID: 34512342    Free PMC article.
New approaches to first-line treatment of advanced renal cell carcinoma.
Daniel J George, Chung-Han Lee, Daniel Heng.
Ther Adv Med Oncol, 2021 Sep 17; 13. PMID: 34527080    Free PMC article.
Review.
Bioinformatics analysis reveals biomarkers with cancer stem cell characteristics in kidney renal clear cell carcinoma.
Zan Zhang, Xueyang Xiong, +3 authors, Lida Xu.
Transl Androl Urol, 2021 Sep 18; 10(8). PMID: 34532274    Free PMC article.
Establishment of a nomogram with EMP3 for predicting clinical outcomes in patients with glioma: A bi-center study.
Anke Zhang, Houshi Xu, +12 authors, Jianmin Zhang.
CNS Neurosci Ther, 2021 Jul 17; 27(10). PMID: 34268874    Free PMC article.
PD-1/PD-L1 inhibitors-based treatment for advanced renal cell carcinoma: Mechanisms affecting efficacy and combination therapies.
Lei Ding, Hui Yu Dong, +6 authors, Chao Liang.
Cancer Med, 2021 Aug 13; 10(18). PMID: 34382349    Free PMC article.
Review.
The Immune Landscape of Chinese Head and Neck Adenoid Cystic Carcinoma and Clinical Implication.
Shengjin Dou, Rongrong Li, +9 authors, Guopei Zhu.
Front Immunol, 2021 Sep 24; 12. PMID: 34552580    Free PMC article.
Characterization of hypoxia response patterns identified prognosis and immunotherapy response in bladder cancer.
Rui Cao, Bo Ma, +3 authors, Lushun Yuan.
Mol Ther Oncolytics, 2021 Sep 24; 22. PMID: 34553019    Free PMC article.
TBC1D3 family is a prognostic biomarker and correlates with immune infiltration in kidney renal clear cell carcinoma.
Bei Wang, Dandan Chen, Haiying Hua.
Mol Ther Oncolytics, 2021 Sep 24; 22. PMID: 34553038    Free PMC article.
Single-cell protein activity analysis identifies recurrence-associated renal tumor macrophages.
Aleksandar Obradovic, Nivedita Chowdhury, +14 authors, Charles G Drake.
Cell, 2021 May 22; 184(11). PMID: 34019793    Free PMC article.
Uncovering the Association Between m5C Regulator-Mediated Methylation Modification Patterns and Tumour Microenvironment Infiltration Characteristics in Hepatocellular Carcinoma.
Xinyu Gu, Haibo Zhou, +3 authors, Haihong Zhu.
Front Cell Dev Biol, 2021 Oct 01; 9. PMID: 34589490    Free PMC article.
CD177 modulates the function and homeostasis of tumor-infiltrating regulatory T cells.
Myung-Chul Kim, Nicholas Borcherding, +32 authors, Weizhou Zhang.
Nat Commun, 2021 Oct 03; 12(1). PMID: 34599187    Free PMC article.
Deciphering Intratumoral Molecular Heterogeneity in Clear Cell Renal Cell Carcinoma with a Radiogenomics Platform.
Durga Udayakumar, Ze Zhang, +24 authors, Ivan Pedrosa.
Clin Cancer Res, 2021 Jul 03; 27(17). PMID: 34210685    Free PMC article.
Intratumor heterogeneity: the hidden barrier to immunotherapy against MSI tumors from the perspective of IFN-γ signaling and tumor-infiltrating lymphocytes.
Wantao Wu, Yihan Liu, +2 authors, Hong Shen.
J Hematol Oncol, 2021 Oct 09; 14(1). PMID: 34620200    Free PMC article.
Review.
Key sunitinib-related biomarkers for renal cell carcinoma.
Yun Peng, Shiqiang Dong, +4 authors, Haitao Wang.
Cancer Med, 2021 Aug 18; 10(19). PMID: 34402193    Free PMC article.
Immune cell infiltration signatures identified molecular subtypes and underlying mechanisms in gastric cancer.
Yilin Lin, Xiaoxian Pan, +8 authors, Zhanlong Shen.
NPJ Genom Med, 2021 Oct 13; 6(1). PMID: 34635662    Free PMC article.
Decreased interferon regulatory factor 6 expression due to DNA hypermethylation predicts an unfavorable prognosis in clear cell renal cell carcinoma.
Zhi Li, Wuping Yang, +5 authors, Yuan Li.
J Cancer, 2021 Oct 19; 12(22). PMID: 34659554    Free PMC article.
Expression of Ferroptosis-Related Genes Shapes Tumor Microenvironment and Pharmacological Profile in Gastric Cancer.
Shilang Xiao, Xiaoming Liu, +2 authors, Fen Wang.
Front Cell Dev Biol, 2021 Oct 19; 9. PMID: 34660573    Free PMC article.
Immune-Related LncRNAs Affect the Prognosis of Osteosarcoma, Which Are Related to the Tumor Immune Microenvironment.
Qingshan Huang, Yilin Lin, +12 authors, Wei Guo.
Front Cell Dev Biol, 2021 Oct 26; 9. PMID: 34692688    Free PMC article.
Immunogenomic Analyses of the Prognostic Predictive Model for Patients With Renal Cancer.
Tao Feng, Jiahui Zhao, +8 authors, Yong Luo.
Front Immunol, 2021 Oct 30; 12. PMID: 34712244    Free PMC article.
A Cell Cycle Progression-Derived Gene Signature to Predict Prognosis and Therapeutic Response in Hepatocellular Carcinoma.
Yongfeng Hui, Junzhi Leng, +4 authors, Yanyang Wang.
Dis Markers, 2021 Nov 02; 2021. PMID: 34721731    Free PMC article.
Integrated analysis reveals distinct molecular, clinical, and immunological features of B7-H3 in acute myeloid leukemia.
Ling-Yi Zhang, Ye Jin, +9 authors, Jun Qian.
Cancer Med, 2021 Sep 26; 10(21). PMID: 34562306    Free PMC article.
BDNF Acts as a Prognostic Factor Associated with Tumor-Infiltrating Th2 Cells in Pancreatic Adenocarcinoma.
Yanan Zhu, Cangang Zhang, +4 authors, Dongyan Zhao.
Dis Markers, 2021 Nov 16; 2021. PMID: 34777634    Free PMC article.
Tumor-Infiltrating CD8+ T Cells Driven by the Immune Checkpoint-Associated Gene IDO1 Are Associated With Cervical Cancer Prognosis.
Shun Zhang, Junhui Wan, +3 authors, Qi Chen.
Front Oncol, 2021 Nov 16; 11. PMID: 34778035    Free PMC article.
Establishment and verification of a prognostic tumor microenvironment-based and immune-related gene signature in colon cancer.
Tianyu Guo, Zhe Wang, Yefu Liu.
J Gastrointest Oncol, 2021 Nov 19; 12(5). PMID: 34790383    Free PMC article.
Overexpressing IFITM family genes predict poor prognosis in kidney renal clear cell carcinoma.
Ying Xu, Danqi Huang, +4 authors, Hui Xiong.
Transl Androl Urol, 2021 Nov 23; 10(10). PMID: 34804826    Free PMC article.
AQP9 Is a Prognostic Factor for Kidney Cancer and a Promising Indicator for M2 TAM Polarization and CD8+ T-Cell Recruitment.
Jibo Jing, Jin Sun, +7 authors, Ming Chen.
Front Oncol, 2021 Nov 23; 11. PMID: 34804972    Free PMC article.
The Dark Side of Pyroptosis of Diffuse Large B-Cell Lymphoma in B-Cell Non-Hodgkin Lymphoma: Mediating the Specific Inflammatory Microenvironment.
Wei Wang, Shi-Wen Xu, +6 authors, Wen-da Luo.
Front Cell Dev Biol, 2021 Nov 23; 9. PMID: 34805183    Free PMC article.
Pyroptosis-related gene mediated modification patterns and immune cell infiltration landscapes in cutaneous melanoma to aid immunotherapy.
Jinzhi Meng, Xing Huang, +4 authors, Jun Yao.
Aging (Albany NY), 2021 Nov 11; 13(21). PMID: 34753832    Free PMC article.
Updates on Immunotherapy and Immune Landscape in Renal Clear Cell Carcinoma.
Myung-Chul Kim, Zeng Jin, +4 authors, Weizhou Zhang.
Cancers (Basel), 2021 Nov 28; 13(22). PMID: 34831009    Free PMC article.
Review.
From Bench to Bedside: How the Tumor Microenvironment Is Impacting the Future of Immunotherapy for Renal Cell Carcinoma.
Jonathan Anker, Justin Miller, +2 authors, Che-Kai Tsao.
Cells, 2021 Nov 28; 10(11). PMID: 34831452    Free PMC article.
Review.
Comprehensive analysis of prognostic immune-related genes and drug sensitivity in cervical cancer.
Ya-Nan Pi, Jun-Nan Guo, Ge Lou, Bin-Bin Cui.
Cancer Cell Int, 2021 Dec 03; 21(1). PMID: 34852825    Free PMC article.
Molecular Mechanisms of Resistance to Immunotherapy and Antiangiogenic Treatments in Clear Cell Renal Cell Carcinoma.
Pablo Álvarez Ballesteros, Jesús Chamorro, +6 authors, Javier Molina-Cerrillo.
Cancers (Basel), 2021 Dec 11; 13(23). PMID: 34885091    Free PMC article.
Review.
Identification of CCL4 as an Immune-Related Prognostic Biomarker Associated With Tumor Proliferation and the Tumor Microenvironment in Clear Cell Renal Cell Carcinoma.
Lu Zhang, Mengzhao Zhang, +9 authors, Jinhai Fan.
Front Oncol, 2021 Dec 14; 11. PMID: 34900664    Free PMC article.
Establishment of a Prognostic Signature of Stromal/Immune-Related Genes for Gastric Adenocarcinoma Based on ESTIMATE Algorithm.
Shan Yu, Yan Wang, +3 authors, Tianshu Liu.
Front Cell Dev Biol, 2021 Dec 14; 9. PMID: 34900998    Free PMC article.
Comprehensive Analysis of m6A Regulators Characterized by the Immune Cell Infiltration in Head and Neck Squamous Cell Carcinoma to Aid Immunotherapy and Chemotherapy.
Zhiqiang Yang, Xiaoping Ming, +3 authors, Jiayu Fang.
Front Oncol, 2021 Dec 18; 11. PMID: 34917507    Free PMC article.
DNA Methylation Modification Map to Predict Tumor Molecular Subtypes and Efficacy of Immunotherapy in Bladder Cancer.
Fangdie Ye, Yingchun Liang, +6 authors, Haowen Jiang.
Front Cell Dev Biol, 2021 Dec 21; 9. PMID: 34926451    Free PMC article.
CD248+ Cancer-Associated Fibroblasts: A Novel Prognostic and Therapeutic Target for Renal Cell Carcinoma.
Chao Xu, Keying Zhang, +12 authors, Weijun Qin.
Front Oncol, 2022 Jan 01; 11. PMID: 34970489    Free PMC article.
Identification of a Novel Defined Immune-Autophagy-Related Gene Signature Associated With Clinical and Prognostic Features of Kidney Renal Clear Cell Carcinoma.
Guangyuan Zhang, Lei Zhang, Si Sun, Ming Chen.
Front Mol Biosci, 2022 Jan 07; 8. PMID: 34988121    Free PMC article.
Genomic and Transcriptomic Correlates of Thyroid Carcinoma Evolution after BRAF Inhibitor Therapy.
Mark Lee, Brian R Untch, +14 authors, Luc G T Morris.
Mol Cancer Res, 2021 Oct 13; 20(1). PMID: 34635506    Free PMC article.
Prognostic Significance of NLR About NETosis and Lymphocytes Perturbations in Localized Renal Cell Carcinoma With Tumor Thrombus.
Bingqing Shang, Liping Guo, +12 authors, Jianzhong Shou.
Front Oncol, 2022 Jan 08; 11. PMID: 34993135    Free PMC article.
T and NK cell abundance defines two distinct subgroups of renal cell carcinoma.
Moon Hee Lee, Petrus Järvinen, +8 authors, Anna Kreutzman.
Oncoimmunology, 2022 Jan 11; 11(1). PMID: 35003893    Free PMC article.
External Validation of the Prognostic Value of an Immune-Associated Gene Panel for Clear Cell Renal Cell Carcinomas.
Zhiwen Xie, Lei Wu, +7 authors, Juntao Jiang.
Front Cell Dev Biol, 2022 Jan 11; 9. PMID: 35004689    Free PMC article.
Senescence as a dictator of patient outcomes and therapeutic efficacies in human gastric cancer.
Lulin Zhou, Zubiao Niu, +11 authors, Qiang Sun.
Cell Death Discov, 2022 Jan 12; 8(1). PMID: 35013121    Free PMC article.
Identification of a competing endogenous RNA network related to immune signature in clear cell renal cell carcinoma.
Yuke Zhang, Jiangwen Dai, +5 authors, Peng Zhang.
Aging (Albany NY), 2021 Dec 28; 13(24). PMID: 34958632    Free PMC article.
A Bioinformatic Analysis of Immune-Related Prognostic Genes in Clear Cell Renal Cell Carcinoma Based on TCGA and GEO Databases.
Jianpeng Li, Jinlong Cao, +4 authors, Junqiang Tian.
Int J Gen Med, 2022 Jan 18; 15. PMID: 35035230    Free PMC article.
Characteristics of the Immune Cell Infiltration Landscape in Gastric Cancer to Assistant Immunotherapy.
Chenlu Li, Jingjing Pan, +3 authors, Xupeng Chen.
Front Genet, 2022 Jan 25; 12. PMID: 35069691    Free PMC article.
Multi-tumor analysis of cancer-stroma interactomes of patient-derived xenografts unveils the unique homeostatic process in renal cell carcinomas.
Kuniyo Sueyoshi, Daisuke Komura, +10 authors, Shumpei Ishikawa.
iScience, 2022 Jan 27; 24(11). PMID: 35079698    Free PMC article.
Development of an Aging-Related Gene Signature for Predicting Prognosis, Immunotherapy, and Chemotherapy Benefits in Rectal Cancer.
Yangyang Wang, Yan Liu, +2 authors, Guodong Li.
Front Mol Biosci, 2022 Jan 28; 8. PMID: 35083278    Free PMC article.
Identification and immunoprofiling of key prognostic genes in the tumor microenvironment of hepatocellular carcinoma.
Tianbing Wang, Bang Chen, +2 authors, Wenyong Wu.
Bioengineered, 2021 May 07; 12(1). PMID: 33955820    Free PMC article.
Nucleolar protein NOP2 could serve as a potential prognostic predictor for clear cell renal cell carcinoma.
Gang Wang, Fangfang Qu, +2 authors, Yi Wang.
Bioengineered, 2021 Aug 03; 12(1). PMID: 34334108    Free PMC article.
Microenvironment-associated gene HSD11B1 may serve as a prognostic biomarker in clear cell renal cell carcinoma: a study based on TCGA, RT‑qPCR, Western blotting, and immunohistochemistry.
Di Han, Zhongjie Yu, +3 authors, Donmeng Qian.
Bioengineered, 2021 Dec 01; 12(2). PMID: 34845968    Free PMC article.
The prognostic value of plasma complement factor B (CFB) in thyroid carcinoma.
Pu Wu, Jinyuan Shi, Wei Sun, Hao Zhang.
Bioengineered, 2021 Dec 14; 12(2). PMID: 34898340    Free PMC article.
Immunotherapy: A new standard in the treatment of metastatic clear cell renal cell carcinoma.
Maja Popovic, Gorana Matovina-Brko, Masa Jovic, Lazar S Popovic.
World J Clin Oncol, 2022 Feb 05; 13(1). PMID: 35116230    Free PMC article.
Review.
PUM1 is upregulated by DNA methylation to suppress antitumor immunity and results in poor prognosis in pancreatic cancer.
Yishi Yang, Xingxing Su, +9 authors, Zhiyu Chen.
Transl Cancer Res, 2022 Feb 05; 10(5). PMID: 35116535    Free PMC article.
Tumor-derived exosomes facilitate tumor cells escape from drug therapy in clear cell renal cell carcinoma.
Xiaogang Wang, Qianqian Shi, +6 authors, Yunjie Cao.
Transl Cancer Res, 2020 May 01; 9(5). PMID: 35117707    Free PMC article.
Phase I clinical trial evaluating the safety and efficacy of ADP-A2M10 SPEAR T cells in patients with MAGE-A10+ advanced non-small cell lung cancer.
George R Blumenschein, Siddhartha Devarakonda, +24 authors, Paula M Fracasso.
J Immunother Cancer, 2022 Jan 29; 10(1). PMID: 35086946    Free PMC article.
Pan-cancer analyses reveal that increased Hedgehog activity correlates with tumor immunosuppression and resistance to immune checkpoint inhibitors.
Junjie Jiang, Yongfeng Ding, +6 authors, Lisong Teng.
Cancer Med, 2021 Nov 30; 11(3). PMID: 34841742    Free PMC article.
As a prognostic biomarker of clear cell renal cell carcinoma RUFY4 predicts immunotherapy responsiveness in a PDL1-related manner.
Daojia Miao, Jian Shi, +6 authors, Xiaoping Zhang.
Cancer Cell Int, 2022 Feb 10; 22(1). PMID: 35135552    Free PMC article.
Crosstalk Between Four Types of RNA Modification Writers Characterizes the Tumor Immune Microenvironment Infiltration Patterns in Skin Cutaneous Melanoma.
Shichao Zhang, Yu Xiong, +5 authors, Fuzhou Tang.
Front Cell Dev Biol, 2022 Feb 15; 10. PMID: 35155433    Free PMC article.
Metastatic Immune-Related Genes for Affecting Prognosis and Immune Response in Renal Clear Cell Carcinoma.
Si Sun, Weipu Mao, +5 authors, Ming Chen.
Front Mol Biosci, 2022 Feb 15; 8. PMID: 35155566    Free PMC article.
A Novel Prognostic Predictor of Immune Microenvironment and Therapeutic Response in Kidney Renal Clear Cell Carcinoma based on Necroptosis-related Gene Signature.
Wenwei Chen, Wenfeng Lin, +3 authors, Peng Huang.
Int J Med Sci, 2022 Feb 16; 19(2). PMID: 35165523    Free PMC article.
Analysis of m6A Methylation Modification Patterns and Tumor Immune Microenvironment in Breast Cancer.
Menglu Dong, Wenzhuang Shen, +2 authors, Xingrui Li.
Front Cell Dev Biol, 2022 Feb 19; 10. PMID: 35178386    Free PMC article.
Understanding the Critical Role of Glycolysis-Related lncRNAs in Lung Adenocarcinoma Based on Three Molecular Subtypes.
Peng Cao, Bo Zhao, +9 authors, Fan Li.
Biomed Res Int, 2022 Feb 19; 2022. PMID: 35178454    Free PMC article.
Alternative splicing and alternative polyadenylation define tumor immune microenvironment and pharmacogenomic landscape in clear cell renal carcinoma.
Weimin Zhong, Yulong Wu, +4 authors, Jiyi Huang.
Mol Ther Nucleic Acids, 2022 Feb 26; 27. PMID: 35211354    Free PMC article.
Histologic-Based Tumor-Associated Immune Cells Status in Clear Cell Renal Cell Carcinoma Correlates with Gene Signatures Related to Cancer Immunity and Clinical Outcomes.
Chisato Ohe, Takashi Yoshida, +10 authors, Koji Tsuta.
Biomedicines, 2022 Feb 26; 10(2). PMID: 35203532    Free PMC article.
Stem-like CD8 T cells mediate response of adoptive cell immunotherapy against human cancer.
Sri Krishna, Frank J Lowery, +19 authors, Steven A Rosenberg.
Science, 2020 Dec 12; 370(6522). PMID: 33303615    Free PMC article.
Links Between N 6-Methyladenosine and Tumor Microenvironments in Colorectal Cancer.
Yundi Zhang, Ke Zhang, +5 authors, Song Li.
Front Cell Dev Biol, 2022 Mar 01; 10. PMID: 35223837    Free PMC article.
From Mouse to Human: Cellular Morphometric Subtype Learned From Mouse Mammary Tumors Provides Prognostic Value in Human Breast Cancer.
Hang Chang, Xu Yang, +11 authors, Jian-Hua Mao.
Front Oncol, 2022 Mar 05; 11. PMID: 35242697    Free PMC article.
Molecular Characteristics, Oncogenic Roles, and Relevant Immune and Pharmacogenomic Features of EVA1B in Colorectal Cancer.
Bin Ma, Kangchun Wang, +2 authors, Yongmin Li.
Front Immunol, 2022 Mar 08; 13. PMID: 35250982    Free PMC article.
Characterization of m6A regulator-mediated methylation modification patterns and tumor microenvironment infiltration in acute myeloid leukemia.
Shiyu Han, Jiaqian Qi, +4 authors, Yue Han.
Cancer Med, 2022 Jan 14; 11(5). PMID: 35023630    Free PMC article.
Comprehensive analysis of pyroptosis regulation patterns and their influence on tumor immune microenvironment and patient prognosis in glioma.
Tianyu Fan, Yi Wan, +6 authors, Li Zhang.
Discov Oncol, 2022 Mar 12; 13(1). PMID: 35274175    Free PMC article.
An Oxidative Stress-Related Genes Signature for Predicting Survival in Bladder Cancer: Based on TCGA Database and Bioinformatics.
Min Zhang, Gang Du, +5 authors, Zhanhong Tang.
Int J Gen Med, 2022 Mar 19; 15. PMID: 35300137    Free PMC article.
Identification of a Methylation-Regulating Genes Prognostic Signature to Predict the Prognosis and Aid Immunotherapy of Clear Cell Renal Cell Carcinoma.
Li Zhang, Zhixiong Su, Fuyuan Hong, Lei Wang.
Front Cell Dev Biol, 2022 Mar 22; 10. PMID: 35309925    Free PMC article.
Angiogenesis Inhibitors and Immunomodulation in Renal Cell Cancers: The Past, Present, and Future.
Lawrence Kasherman, Derrick Ho Wai Siu, Rachel Woodford, Carole A Harris.
Cancers (Basel), 2022 Mar 26; 14(6). PMID: 35326557    Free PMC article.
Review.
Phase 1 Clinical Trial Evaluating the Safety and Anti-Tumor Activity of ADP-A2M10 SPEAR T-Cells in Patients With MAGE-A10+ Head and Neck, Melanoma, or Urothelial Tumors.
David S Hong, Marcus O Butler, +22 authors, Paula M Fracasso.
Front Oncol, 2022 Apr 05; 12. PMID: 35372008    Free PMC article.
Immunosuppressive tumor-associated macrophages expressing interlukin-10 conferred poor prognosis and therapeutic vulnerability in patients with muscle-invasive bladder cancer.
Yijia Xu, Han Zeng, +6 authors, Jiejie Xu.
J Immunother Cancer, 2022 Mar 27; 10(3). PMID: 35338085    Free PMC article.
Integrated Multi-Omics Analysis Identified PTPRG and CHL1 as Key Regulators of Immunophenotypes in Clear Cell Renal Cell Carcinoma(ccRCC).
Xing Zeng, Le Li, Zhiquan Hu, Dan Peng.
Front Oncol, 2022 Apr 19; 12. PMID: 35433461    Free PMC article.
Heterogeneity of neuroendocrine transcriptional states in metastatic small cell lung cancers and patient-derived models.
Delphine Lissa, Nobuyuki Takahashi, +16 authors, Anish Thomas.
Nat Commun, 2022 Apr 21; 13(1). PMID: 35440132    Free PMC article.
A proteogenomic analysis of clear cell renal cell carcinoma in a Chinese population.
Yuanyuan Qu, Jinwen Feng, +22 authors, Chen Ding.
Nat Commun, 2022 Apr 21; 13(1). PMID: 35440542    Free PMC article.
Clinicopathological and Prognostic Significance of Stromal Patterns in Oral Squamous Cell Carcinoma.
Yusuke Amano, Atsushi Kihara, +6 authors, Toshiro Niki.
Front Med (Lausanne), 2022 May 03; 9. PMID: 35492308    Free PMC article.
Comprehensive Analysis of Subtypes and Identification of Key lncRNAs Based on Glutamine Metabolism-Related Long Noncoding RNAs.
Yuwei Feng, Xiaowei Sun, +5 authors, Yanhua Wang.
Comput Math Methods Med, 2022 May 10; 2022. PMID: 35529265    Free PMC article.
Molecular characteristics of novel immune subtypes of HCC based on lncRNAs related to immune disorders.
Qiyao Zhang, Xiao Yu, +2 authors, Yuting He.
Sci Rep, 2022 May 27; 12(1). PMID: 35618810
mTOR pathway gene mutations predict response to immune checkpoint inhibitors in multiple cancers.
Lei Cheng, Yanan Wang, +10 authors, Baohui Han.
J Transl Med, 2022 Jun 02; 20(1). PMID: 35642038
A single-cell map of dynamic chromatin landscapes of immune cells in renal cell carcinoma.
Nikos Kourtis, Qingqing Wang, +19 authors, Dimitris Skokos.
Nat Cancer, 2022 Jun 07;. PMID: 35668194