Review
. 2016 Nov;389(10074).
doi: 10.1016/S0140-6736(16)31891-8.

Breast cancer

Nadia Harbeck 1 Michael Gnant 2 
Affiliations
  • PMID: 27865536
  •     248 citations

Abstract

Breast cancer is one of the three most common cancers worldwide. Early breast cancer is considered potentially curable. Therapy has progressed substantially over the past years with a reduction in therapy intensity, both for locoregional and systemic therapy; avoiding overtreatment but also undertreatment has become a major focus. Therapy concepts follow a curative intent and need to be decided in a multidisciplinary setting, taking molecular subtype and locoregional tumour load into account. Primary conventional surgery is not the optimal choice for all patients any more. In triple-negative and HER2-positive early breast cancer, neoadjuvant therapy has become a commonly used option. Depending on clinical tumour subtype, therapeutic backbones include endocrine therapy, anti-HER2 targeting, and chemotherapy. In metastatic breast cancer, therapy goals are prolongation of survival and maintaining quality of life. Advances in endocrine therapies and combinations, as well as targeting of HER2, and the promise of newer targeted therapies make the prospect of long-term disease control in metastatic breast cancer an increasing reality.

Increased trace amine-associated receptor 1 (TAAR1) expression is associated with a positive survival rate in patients with breast cancer.
Aurelia Vattai, Elif Akyol, +12 authors, Nina Ditsch.
J Cancer Res Clin Oncol, 2017 Apr 15; 143(9). PMID: 28409272
Bioinformatic Prediction of Possible Targets and Mechanisms of Action of the Green Tea Compound Epigallocatechin-3-Gallate Against Breast Cancer.
Xinqiang Song, Mu Zhang, Lei Chen, Qingsong Lin.
Front Mol Biosci, 2017 Jul 18; 4. PMID: 28713815    Free PMC article.
Impact of Etoposide on BRCA1 Expression in Various Breast Cancer Cell Lines.
Xi Zhang, Simone Hofmann, +2 authors, Sophie Sixou.
Drugs R D, 2017 Sep 08; 17(4). PMID: 28879638    Free PMC article.
Cardiovascular disease and mortality after breast cancer in postmenopausal women: Results from the Women's Health Initiative.
Na-Jin Park, Yuefang Chang, +7 authors, Lewis H Kuller.
PLoS One, 2017 Sep 22; 12(9). PMID: 28934233    Free PMC article.
Using a novel T-lymph node ratio model to evaluate the prognosis of nonmetastatic breast cancer patients who received preoperative radiotherapy followed by mastectomy: An observational study.
Yang Wang, Yuanyuan Zhao, +5 authors, Shengying Wang.
Medicine (Baltimore), 2017 Oct 20; 96(42). PMID: 29049205    Free PMC article.
The influence of stage at diagnosis and molecular subtype on breast cancer patient survival: a hospital-based multi-center study.
Tingting Zuo, Hongmei Zeng, +9 authors, Wanqing Chen.
Chin J Cancer, 2017 Oct 27; 36(1). PMID: 29070080    Free PMC article.
Aptamer selection and applications for breast cancer diagnostics and therapy.
Mei Liu, Xiaocheng Yu, +9 authors, Nongyue He.
J Nanobiotechnology, 2017 Nov 15; 15(1). PMID: 29132385    Free PMC article.
Review.
The Predictive Value of PITX2 DNA Methylation for High-Risk Breast Cancer Therapy: Current Guidelines, Medical Needs, and Challenges.
Michaela Aubele, Manfred Schmitt, +8 authors, Marion Kiechle.
Dis Markers, 2017 Nov 16; 2017. PMID: 29138528    Free PMC article.
Review.
Effect of exosome biomarkers for diagnosis and prognosis of breast cancer patients.
M Wang, S Ji, +4 authors, A Wu.
Clin Transl Oncol, 2017 Nov 17; 20(7). PMID: 29143228
Systematic Review.
Triptorelin: A Review of its Use as an Adjuvant Anticancer Therapy in Early Breast Cancer.
James E Frampton.
Drugs, 2017 Nov 28; 77(18). PMID: 29177573
Review.
Risk Factors and Preventions of Breast Cancer.
Yi-Sheng Sun, Zhao Zhao, +7 authors, Han-Ping Zhu.
Int J Biol Sci, 2017 Dec 07; 13(11). PMID: 29209143    Free PMC article.
Highly Cited. Review.
A prognostic 4-gene expression signature for patients with HER2-negative breast cancer receiving taxane and anthracycline-based chemotherapy.
Pu Cheng, Zhen Wang, +3 authors, Jian Huang.
Oncotarget, 2017 Dec 22; 8(61). PMID: 29262565    Free PMC article.
GOLPH3: a novel biomarker that correlates with poor survival and resistance to chemotherapy in breast cancer.
Shicong Tang, Hong Pan, +3 authors, Rirong Yang.
Oncotarget, 2017 Dec 30; 8(62). PMID: 29285241    Free PMC article.
PITX2 DNA-methylation predicts response to anthracycline-based adjuvant chemotherapy in triple-negative breast cancer patients.
Magdalena Absmaier, Rudolf Napieralski, +9 authors, Manfred Schmitt.
Int J Oncol, 2018 Jan 13; 52(3). PMID: 29328369    Free PMC article.
Score for the Survival Probability in Metastasis Breast Cancer: A Nomogram-Based Risk Assessment Model.
Zhenchong Xiong, Guangzheng Deng, +5 authors, Xi Wang.
Cancer Res Treat, 2018 Jan 16; 50(4). PMID: 29334609    Free PMC article.
Elevated Aromatase (CYP19A1) Expression Is Associated with a Poor Survival of Patients with Estrogen Receptor Positive Breast Cancer.
Andrea Friesenhengst, Tamara Pribitzer-Winner, +2 authors, Martin Schreiber.
Horm Cancer, 2018 Jan 25; 9(2). PMID: 29363090    Free PMC article.
Triple Negative Breast Cancer Depends on Sphingosine Kinase 1 (SphK1)/Sphingosine-1-Phosphate (S1P)/Sphingosine 1-Phosphate Receptor 3 (S1PR3)/Notch Signaling for Metastasis.
Shushu Wang, Yueyang Liang, +2 authors, Yi Zhang.
Med Sci Monit, 2018 Apr 02; 24. PMID: 29605826    Free PMC article.
Up-regulation of ceRNA TINCR by SP1 contributes to tumorigenesis in breast cancer.
Yun Liu, Yaying Du, +2 authors, Wenfei Xia.
BMC Cancer, 2018 Apr 05; 18(1). PMID: 29614984    Free PMC article.
Angiogenic role of miR-20a in breast cancer.
Gines Luengo-Gil, Enrique Gonzalez-Billalabeitia, +6 authors, Francisco Ayala de la Peña.
PLoS One, 2018 Apr 05; 13(4). PMID: 29617404    Free PMC article.
99mTc-labeled sodium phytate and stannous chloride injection accurately detects sentinel lymph node in axillary of early stage breast cancer: a randomized, controlled study.
Suisheng Yang, Weiyu Bao, +3 authors, Zhuanji Jiang.
Onco Targets Ther, 2018 Apr 20; 11. PMID: 29670364    Free PMC article.
Current Therapies for Human Epidermal Growth Factor Receptor 2-Positive Metastatic Breast Cancer Patients.
Alexey A Larionov.
Front Oncol, 2018 Apr 20; 8. PMID: 29670855    Free PMC article.
Review.
Spatiotemporal assessment of spontaneous metastasis formation using multimodal in vivo imaging in HER2+ and triple negative metastatic breast cancer xenograft models in mice.
Inga B Fricke, Raquel De Souza, +4 authors, Jinzi Zheng.
PLoS One, 2018 May 04; 13(5). PMID: 29723251    Free PMC article.
Temozolomide Enhances Triple-Negative Breast Cancer Virotherapy In Vitro.
Rodolfo Garza-Morales, Roxana Gonzalez-Ramos, +4 authors, Jorge G Gomez-Gutierrez.
Cancers (Basel), 2018 May 19; 10(5). PMID: 29772755    Free PMC article.
Betulinic acid chemosensitizes breast cancer by triggering ER stress-mediated apoptosis by directly targeting GRP78.
Youli Cai, Yifeng Zheng, +7 authors, Zhiyu Wang.
Cell Death Dis, 2018 May 29; 9(6). PMID: 29802332    Free PMC article.
LRP5 regulates the expression of STK40, a new potential target in triple-negative breast cancers.
Sylvie Maubant, Tania Tahtouh, +16 authors, Thierry Dubois.
Oncotarget, 2018 Jun 02; 9(32). PMID: 29854300    Free PMC article.
Precision cardio-oncology: understanding the cardiotoxicity of cancer therapy.
Xinqiang Han, Yun Zhou, Wendi Liu.
NPJ Precis Oncol, 2018 Jun 07; 1(1). PMID: 29872712    Free PMC article.
Review.
Identification and validation of single-sample breast cancer radiosensitivity gene expression predictors.
Martin Sjöström, Johan Staaf, +6 authors, Irma Fredriksson.
Breast Cancer Res, 2018 Jul 06; 20(1). PMID: 29973242    Free PMC article.
Neoadjuvant treatment of HER2-positive breast cancer: should therapy differ based on hormone receptor status?
Nadia Harbeck.
Ther Adv Med Oncol, 2018 Jul 24; 10. PMID: 30034548    Free PMC article.
LncRNA MIR100HG promotes cell proliferation in triple-negative breast cancer through triplex formation with p27 loci.
Shaowei Wang, Hao Ke, +8 authors, Baowei Jiao.
Cell Death Dis, 2018 Jul 26; 9(8). PMID: 30042378    Free PMC article.
Co-expressed genes enhance precision of receptor status identification in breast cancer patients.
Michael Kenn, Dan Cacsire Castillo-Tong, +3 authors, Wolfgang Schreiner.
Breast Cancer Res Treat, 2018 Aug 18; 172(2). PMID: 30117066    Free PMC article.
Scinderin-knockdown inhibits proliferation and promotes apoptosis in human breast carcinoma cells.
Wenjing Jian, Xiaoli Zhang, +4 authors, Renbin Liu.
Oncol Lett, 2018 Aug 22; 16(3). PMID: 30127916    Free PMC article.
Mitochondria-targeted delivery of doxorubicin to enhance antitumor activity with HER-2 peptide-mediated multifunctional pH-sensitive DQAsomes.
Menghao Shi, Jiulong Zhang, +7 authors, Xiuli Zhao.
Int J Nanomedicine, 2018 Aug 25; 13. PMID: 30140154    Free PMC article.
Differences in Breast Cancer Characteristics by Mammography Screening Participation or Non-Participation.
Bettina Braun, Laura Khil, +4 authors, Hans-Werner Hense.
Dtsch Arztebl Int, 2018 Aug 29; 115(31-32). PMID: 30149831    Free PMC article.
Economic Evaluation of Letrozole for Early Breast Cancer in a Health Resource-Limited Setting.
Ming Ye, Jingsong Lu, Fan Yang, Bin Wu.
Biomed Res Int, 2018 Aug 30; 2018. PMID: 30155484    Free PMC article.
miR-376a inhibits breast cancer cell progression by targeting neuropilin-1 NR.
Lansheng Zhang, Yanwei Chen, +3 authors, Zhengxiang Han.
Onco Targets Ther, 2018 Sep 15; 11. PMID: 30214235    Free PMC article.
The efficacy and safety of targeted therapy plus fulvestrant in postmenopausal women with hormone-receptor positive advanced breast cancer: A meta-analysis of randomized-control trials.
Gao Chanchan, Su Xiangyu, +2 authors, Gu Xiaoyi.
PLoS One, 2018 Sep 21; 13(9). PMID: 30235292    Free PMC article.
A Mendelian randomization study of the effects of blood lipids on breast cancer risk.
Christoph Nowak, Johan Ärnlöv.
Nat Commun, 2018 Sep 29; 9(1). PMID: 30262900    Free PMC article.
Long Noncoding RNA Signature and Disease Outcome in Estrogen Receptor-Positive Breast Cancer Patients Treated with Tamoxifen.
Gen Wang, Xiaosong Chen, +3 authors, Kunwei Shen.
J Breast Cancer, 2018 Oct 03; 21(3). PMID: 30275856    Free PMC article.
AFF3 upregulation mediates tamoxifen resistance in breast cancers.
Yawei Shi, Yang Zhao, +5 authors, Shenming Wang.
J Exp Clin Cancer Res, 2018 Oct 18; 37(1). PMID: 30326937    Free PMC article.
Clinical performance of an analytically validated assay in comparison to microarray technology to assess PITX2 DNA-methylation in breast cancer.
Gabriele Schricker, Rudolf Napieralski, +12 authors, Olaf G Wilhelm.
Sci Rep, 2018 Nov 18; 8(1). PMID: 30442983    Free PMC article.
Association between sleep-disordered breathing and breast cancer aggressiveness.
Francisco Campos-Rodriguez, Antonio Cruz-Medina, +5 authors, Miguel Angel Martinez-Garcia.
PLoS One, 2018 Nov 22; 13(11). PMID: 30462710    Free PMC article.
Global treatment costs of breast cancer by stage: A systematic review.
Li Sun, Rosa Legood, +2 authors, Zia Sadique.
PLoS One, 2018 Nov 27; 13(11). PMID: 30475890    Free PMC article.
Systematic Review.
Increasing intratumor C/EBP-β LIP and nitric oxide levels overcome resistance to doxorubicin in triple negative breast cancer.
Iris C Salaroglio, Elena Gazzano, +8 authors, Joanna Kopecka.
J Exp Clin Cancer Res, 2018 Nov 30; 37(1). PMID: 30482226    Free PMC article.
Whole genome sequencing of breast cancer.
Maria Rossing, Claus Storgaard Sørensen, Bent Ejlertsen, Finn Cilius Nielsen.
APMIS, 2019 Jan 29; 127(5). PMID: 30689231    Free PMC article.
Review.
Bone Sialoprotein Shows Enhanced Expression in Early, High-Proliferation Stages of Three-Dimensional Spheroid Cell Cultures of Breast Cancer Cell Line MDA-MB-231.
Valeh Rustamov, Florian Keller, +2 authors, Rüdiger Rudolf.
Front Oncol, 2019 Feb 26; 9. PMID: 30805306    Free PMC article.
High expression of DLG3 is associated with decreased survival from breast cancer.
Jie Liu, Pingping Li, +4 authors, Peijun Liu.
Clin Exp Pharmacol Physiol, 2019 Jul 05; 46(10). PMID: 31271664    Free PMC article.
Integrin α7 high expression correlates with deteriorative tumor features and worse overall survival, and its knockdown inhibits cell proliferation and invasion but increases apoptosis in breast cancer.
Xiaorong Bai, Chen Gao, Lifeng Zhang, Suisheng Yang.
J Clin Lab Anal, 2019 Jul 22; 33(8). PMID: 31325216    Free PMC article.
Relationships of protein biomarkers of the urokinase plasminogen activator system with expression of their cognate genes in primary breast carcinomas.
Seth B Sereff, Michael W Daniels, James L Wittliff.
J Clin Lab Anal, 2019 Jul 31; 33(9). PMID: 31359505    Free PMC article.
Primary tumor resection for initially staged IV breast cancer: An emphasis on programmed death-ligand 1 expression, promoter methylation status, and survival.
Timuçin Erol, Nazli Eylem İmamoğlu, +4 authors, Ataç Baykal.
Medicine (Baltimore), 2019 Aug 16; 98(33). PMID: 31415379    Free PMC article.
circFBXW7 Inhibits Malignant Progression by Sponging miR-197-3p and Encoding a 185-aa Protein in Triple-Negative Breast Cancer.
Feng Ye, Guanfeng Gao, +5 authors, Hailin Tang.
Mol Ther Nucleic Acids, 2019 Sep 20; 18. PMID: 31536884    Free PMC article.
Highly Cited.
Plasma extracellular vesicle‑packaged microRNAs as candidate diagnostic biomarkers for early‑stage breast cancer.
Chen Yan, Jintao Hu, +4 authors, Nan Xu.
Mol Med Rep, 2019 Sep 24; 20(5). PMID: 31545424    Free PMC article.
Low CYP24A1 mRNA expression and its role in prognosis of breast cancer.
Hongqiao Cai, Yan Jiao, +3 authors, Yahui Liu.
Sci Rep, 2019 Sep 25; 9(1). PMID: 31548577    Free PMC article.
Antitumor Activity of Abnormal Cannabidiol and Its Analog O-1602 in Taxol-Resistant Preclinical Models of Breast Cancer.
Andrea Tomko, Lauren O'Leary, +5 authors, Denis J Dupré.
Front Pharmacol, 2019 Oct 16; 10. PMID: 31611800    Free PMC article.
Identification of RAD54 homolog B as a promising therapeutic target for breast cancer.
Jing Feng, Juanjuan Hu, Ying Xia.
Oncol Lett, 2019 Oct 16; 18(5). PMID: 31612045    Free PMC article.
miR‑425‑5p is associated with poor prognosis in patients with breast cancer and promotes cancer cell progression by targeting PTEN.
Sheng Xiao, Hongjia Zhu, +2 authors, Mingjun Xie.
Oncol Rep, 2019 Oct 23; 42(6). PMID: 31638259    Free PMC article.
Recent Advances in Nuclear Imaging of Receptor Expression to Guide Targeted Therapies in Breast Cancer.
Barbara Salvatore, Maria Grazia Caprio, +3 authors, Antonella Zannetti.
Cancers (Basel), 2019 Oct 28; 11(10). PMID: 31652624    Free PMC article.
Review.
Subtype-Based Prognostic Analysis of Cell-in-Cell Structures in Early Breast Cancer.
Xin Zhang, Zubiao Niu, +10 authors, Qiang Sun.
Front Oncol, 2019 Nov 05; 9. PMID: 31681557    Free PMC article.
Long non-coding RNA UCA1 promotes breast cancer by upregulating PTP1B expression via inhibiting miR-206.
Yi Li, Qingan Zeng, +3 authors, Xuexia Zhang.
Cancer Cell Int, 2019 Nov 07; 19. PMID: 31695578    Free PMC article.
Neoadjuvant Chemotherapy Plays an Adverse Role in the Prognosis of Grade 2 Breast Cancer.
Xudong Zhu, Jinqi Xue, +7 authors, Yixiao Zhang.
J Cancer, 2019 Nov 19; 10(23). PMID: 31737103    Free PMC article.
The Prognosis Of Peroxiredoxin Family In Breast Cancer.
Gang Wang, Wan-Chao Zhong, +4 authors, A-Man Xu.
Cancer Manag Res, 2019 Dec 10; 11. PMID: 31814764    Free PMC article.
Association Between Metabolic Syndrome and Breast Cancer Risk: An Updated Meta-Analysis of Follow-Up Studies.
Meng Guo, Tingting Liu, +7 authors, Ruopeng Zhang.
Front Oncol, 2019 Dec 12; 9. PMID: 31824862    Free PMC article.
Systematic Review.
Association between obstructive sleep apnoea and breast cancer: The Korean National Health Insurance Service Data 2007-2014.
Ji Ho Choi, Jae Yong Lee, +2 authors, Jae Hoon Cho.
Sci Rep, 2019 Dec 15; 9(1). PMID: 31836779    Free PMC article.
Circulating non‑coding RNA‑biomarker potential in neoadjuvant chemotherapy of triple negative breast cancer?
Andrea Ritter, Marc Hirschfeld, +8 authors, Thalia Erbes.
Int J Oncol, 2019 Dec 04; 56(1). PMID: 31789396    Free PMC article.
Methylene Blue-Based Near-Infrared Fluorescence Imaging for Breast Cancer Visualization in Resected Human Tissues.
Chong Zhang, Daqing Jiang, +7 authors, Yahong Luo.
Technol Cancer Res Treat, 2019 Dec 15; 18. PMID: 31835962    Free PMC article.
The role of exosomal long non-coding RNAs in cancer drug resistance.
Mireia Cruz De Los Santos, Mihnea P Dragomir, George A Calin.
Cancer Drug Resist, 2019 Dec 24; 2. PMID: 31867576    Free PMC article.
Treatment of Advanced Hormone Receptor-Positive (HR+) HER2-negative Breast Cancer.
Nina Ditsch, Marcus Schmidt.
Geburtshilfe Frauenheilkd, 2019 Dec 27; 79(12). PMID: 31875862    Free PMC article.
Incorporation of drug efflux inhibitor and chemotherapeutic agent into an inorganic/organic platform for the effective treatment of multidrug resistant breast cancer.
Yang Dong, Hongze Liao, +5 authors, Yourong Duan.
J Nanobiotechnology, 2019 Dec 25; 17(1). PMID: 31870362    Free PMC article.
Clinical and transcriptional signatures of human CD204 reveal an applicable marker for the protumor phenotype of tumor-associated macrophages in breast cancer.
Yunjie He, Siying Zhou, +10 authors, Zuomin Zhou.
Aging (Albany NY), 2019 Dec 05; 11(23). PMID: 31799941    Free PMC article.
LINC00365-SCGB2A1 axis inhibits the viability of breast cancer through targeting NF-κB signaling.
Lichao Zhang, Xiaoyu Yan, +5 authors, Jing Su.
Oncol Lett, 2020 Jan 04; 19(1). PMID: 31897191    Free PMC article.
Bioinformatics analysis of the expression of HOXC13 and its role in the prognosis of breast cancer.
Changyou Li, Junwei Cui, +2 authors, Wei Wei.
Oncol Lett, 2020 Jan 04; 19(1). PMID: 31897205    Free PMC article.
Antiangiogenic effect of crocin on breast cancer cell MDA-MB-231.
Shuang-Shuang Chen, Yuan Gu, +5 authors, Zheng-Hong Yu.
J Thorac Dis, 2020 Jan 07; 11(11). PMID: 31903234    Free PMC article.
Baicalin Inhibits Cell Viability, Migration and Invasion in Breast Cancer by Regulating miR-338-3p and MORC4.
Xin Duan, Guangcheng Guo, +4 authors, Xinguang Qiu.
Onco Targets Ther, 2020 Jan 08; 12. PMID: 31908485    Free PMC article.
Downregulation of CXXC Finger Protein 4 Leads to a Tamoxifen-resistant Phenotype in Breast Cancer Cells Through Activation of the Wnt/β-catenin Pathway.
Yijie Fu, Zhu Wang, +4 authors, Hong Zheng.
Transl Oncol, 2020 Jan 09; 13(2). PMID: 31911277    Free PMC article.
A Case-Control Study of the Association Between the SPP1 Gene SNPs and the Susceptibility to Breast Cancer in Guangxi, China.
Lina Liang, Guanming Lu, +6 authors, Guijiang Wei.
Front Oncol, 2020 Jan 11; 9. PMID: 31921672    Free PMC article.
MicroRNA-130a reduces drug resistance in breast cancer.
Jin Huang, Min Zhao, +3 authors, Li Zheng.
Int J Clin Exp Pathol, 2020 Jan 15; 12(7). PMID: 31934100    Free PMC article.
Enhanced JunD/RSK3 signalling due to loss of BRD4/FOXD3/miR-548d-3p axis determines BET inhibition resistance.
Fang Tai, Kunxiang Gong, +2 authors, Jian Shi.
Nat Commun, 2020 Jan 16; 11(1). PMID: 31937753    Free PMC article.
Bioinformatic analysis of differential expression and core GENEs in breast cancer.
Hongchang Dong, Shuai Zhang, +5 authors, Jin Huang.
Int J Clin Exp Pathol, 2018 Mar 01; 11(3). PMID: 31938209    Free PMC article.
Expression of VEGF, COX-2 and MMP-9 in breast cancer and their relationship with ultrasound findings.
Zhangshen Ran, Lixia Hou, +2 authors, Xiangqi Li.
Int J Clin Exp Pathol, 2018 Sep 01; 11(9). PMID: 31949822    Free PMC article.
Review.
Radiomics based on 18 F-FDG PET/CT could differentiate breast carcinoma from breast lymphoma using machine-learning approach: A preliminary study.
Xuejin Ou, Jing Zhang, +4 authors, Xuelei Ma.
Cancer Med, 2019 Nov 27; 9(2). PMID: 31769230    Free PMC article.
MicroRNA-181d-5p-Containing Exosomes Derived from CAFs Promote EMT by Regulating CDX2/HOXA5 in Breast Cancer.
Hongbin Wang, Hong Wei, +3 authors, Zhigao Li.
Mol Ther Nucleic Acids, 2020 Jan 20; 19. PMID: 31955007    Free PMC article.
Upregulated tumor sirtuin 2 expression correlates with reduced TNM stage and better overall survival in surgical breast cancer patients.
Pengfei Shi, Min Zhou, Yonggang Yang.
Ir J Med Sci, 2019 Aug 17; 189(1). PMID: 31418154
The efficacy and safety of neoadjuvant buparlisib for breast cancer: A meta-analysis of randomized controlled studies.
Qian Luo, Hui Lu, Xian Zhou, Ying Wang.
Medicine (Baltimore), 2019 Nov 07; 98(44). PMID: 31689768    Free PMC article.
Phase 1 Dose Escalation Study of the Allosteric AKT Inhibitor BAY 1125976 in Advanced Solid Cancer-Lack of Association between Activating AKT Mutation and AKT Inhibition-Derived Efficacy.
Andreas Schneeweiss, Dagmar Hess, +12 authors, Matthias Ocker.
Cancers (Basel), 2019 Dec 15; 11(12). PMID: 31835495    Free PMC article.
Association between metabolic syndrome and prognosis of breast cancer: a meta-analysis of follow-up studies.
Peiting Li, Tianying Wang, +4 authors, Wei Wu.
Diabetol Metab Syndr, 2020 Feb 06; 12. PMID: 32015762    Free PMC article.
Molecular and Cellular Risk Assessment of Healthy Human Cells and Cancer Human Cells Exposed to Nanoparticles.
Edward Helal-Neto, Aline Oliveira da Silva de Barros, +9 authors, Ralph Santos-Oliveira.
Int J Mol Sci, 2020 Jan 08; 21(1). PMID: 31905708    Free PMC article.
Cytoplasmic and Nuclear Forms of Thyroid Hormone Receptor β1 Are Inversely Associated with Survival in Primary Breast Cancer.
Wanting Shao, Christina Kuhn, +8 authors, Sophie Sixou.
Int J Mol Sci, 2020 Jan 18; 21(1). PMID: 31947762    Free PMC article.
Shear-Wave Elastography of the Breast: Added Value of a Quality Map in Diagnosis and Prediction of the Biological Characteristics of Breast Cancer.
Xueyi Zheng, Yini Huang, +5 authors, Jianhua Zhou.
Korean J Radiol, 2020 Jan 31; 21(2). PMID: 31997592    Free PMC article.
Predicting the response to neoadjuvant chemotherapy for breast cancer: wavelet transforming radiomics in MRI.
Jiali Zhou, Jinghui Lu, +5 authors, Maosheng Xu.
BMC Cancer, 2020 Feb 07; 20(1). PMID: 32024483    Free PMC article.
A Risk Stratification Model for Predicting Overall Survival and Surgical Benefit in Triple-Negative Breast Cancer Patients With de novo Distant Metastasis.
Zheng Wang, Hui Wang, +5 authors, Kun-Wei Shen.
Front Oncol, 2020 Feb 11; 10. PMID: 32038988    Free PMC article.
Circular RNA hsa_circRNA_002178 silencing retards breast cancer progression via microRNA-328-3p-mediated inhibition of COL1A1.
Ting Liu, Ping Ye, +2 authors, Baosan Han.
J Cell Mol Med, 2020 Jan 21; 24(3). PMID: 31957232    Free PMC article.
Resibufogenin suppresses tumor growth and Warburg effect through regulating miR-143-3p/HK2 axis in breast cancer.
Ying Guo, Fei Liang, Fuli Zhao, Jian Zhao.
Mol Cell Biochem, 2020 Feb 02; 466(1-2). PMID: 32006291
Comprehensive analysis of the association between tumor glycolysis and immune/inflammation function in breast cancer.
Wenhui Li, Ming Xu, +7 authors, Pengfei Yi.
J Transl Med, 2020 Feb 20; 18(1). PMID: 32070368    Free PMC article.
The transcriptional landscape of lncRNAs reveals the oncogenic function of LINC00511 in ER-negative breast cancer.
Jian Zhang, Shiyao Sui, +4 authors, Da Pang.
Cell Death Dis, 2019 Aug 10; 10(8). PMID: 31395854    Free PMC article.
Demethylation of the Cosmc Promoter Alleviates the Progression of Breast Cancer Through Downregulation of the Tn and Sialyl-Tn Antigens.
Feng Xu, Dong Wang, +2 authors, Hongchuan Jiang.
Cancer Manag Res, 2020 Feb 28; 12. PMID: 32104083    Free PMC article.
Cytoplasmic PPARγ is a marker of poor prognosis in patients with Cox-1 negative primary breast cancers.
Wanting Shao, Christina Kuhn, +8 authors, Sophie Sixou.
J Transl Med, 2020 Feb 23; 18(1). PMID: 32085795    Free PMC article.
Post-mastectomy Radiotherapy in T1-2 Breast Cancer Patients With One to Three Lymph Node Metastases: A Propensity Score Matching Analysis.
Maoshan Chen, Yunhui Huang, +4 authors, Lingmi Hou.
Front Oncol, 2020 Mar 03; 9. PMID: 32117784    Free PMC article.
Hypoxia-induced switch in SNAT2/SLC38A2 regulation generates endocrine resistance in breast cancer.
Matteo Morotti, Esther Bridges, +16 authors, Adrian L Harris.
Proc Natl Acad Sci U S A, 2019 Jun 04; 116(25). PMID: 31152137    Free PMC article.
Association between socioeconomic factors at diagnosis and survival in breast cancer: A population-based study.
Peng Ji, Yue Gong, +3 authors, Zhi-Ming Shao.
Cancer Med, 2020 Jan 22; 9(5). PMID: 31960597    Free PMC article.
DLG5 suppresses breast cancer stem cell-like characteristics to restore tamoxifen sensitivity by inhibiting TAZ expression.
Jie Liu, Juan Li, +5 authors, Peijun Liu.
J Cell Mol Med, 2018 Nov 20; 23(1). PMID: 30450766    Free PMC article.
A Bayesian network meta-analysis of the efficacy of targeted therapies and chemotherapy for treatment of triple-negative breast cancer.
Huihui Chen, Wei Lu, +3 authors, Yiding Chen.
Cancer Med, 2018 Dec 14; 8(1). PMID: 30525293    Free PMC article.
An Aptamer-Based Probe for Molecular Subtyping of Breast Cancer.
Mei Liu, Zhifei Wang, +6 authors, Nongyue He.
Theranostics, 2018 Dec 18; 8(20). PMID: 30555580    Free PMC article.
LRP8 is overexpressed in estrogen-negative breast cancers and a potential target for these tumors.
Virginie Maire, Faisal Mahmood, +7 authors, Thierry Dubois.
Cancer Med, 2018 Dec 24; 8(1). PMID: 30575334    Free PMC article.
Depletion of dAKAP1-protein kinase A signaling islands from the outer mitochondrial membrane alters breast cancer cell metabolism and motility.
Stacey Aggarwal, Laura Gabrovsek, +4 authors, John D Scott.
J Biol Chem, 2019 Jan 02; 294(9). PMID: 30598507    Free PMC article.
Drug Combinations in Breast Cancer Therapy.
Funmilola A Fisusi, Emmanuel O Akala.
Pharm Nanotechnol, 2019 Jan 23; 7(1). PMID: 30666921    Free PMC article.
Review.
Licochalcone A Inhibits Cellular Motility by Suppressing E-cadherin and MAPK Signaling in Breast Cancer.
Wen-Chung Huang, Haiso-Han Su, +2 authors, Chian-Jiun Liou.
Cells, 2019 Mar 08; 8(3). PMID: 30841634    Free PMC article.
Cancer-associated fibroblasts: how do they contribute to metastasis?
Mei Qi Kwa, Kate M Herum, Cord Brakebusch.
Clin Exp Metastasis, 2019 Mar 09; 36(2). PMID: 30847799
Review.
Study of diffusion-weighted magnetic resonance imaging in the evaluation of the response to AAV2-VEGF-Trap neoadjuvant treatment in a triple-negative breast cancer animal model.
Jianhua Li, Pengjin Zhu, +3 authors, Fabao Gao.
Cancer Med, 2019 Mar 23; 8(4). PMID: 30900382    Free PMC article.
Microbiome-Microbial Metabolome-Cancer Cell Interactions in Breast Cancer-Familiar, but Unexplored.
Edit Mikó, Tünde Kovács, +7 authors, Péter Bai.
Cells, 2019 Apr 03; 8(4). PMID: 30934972    Free PMC article.
Review.
Integrin α9 depletion promotes β-catenin degradation to suppress triple-negative breast cancer tumor growth and metastasis.
Zhishan Wang, Yunfei Li, +5 authors, Chengfeng Yang.
Int J Cancer, 2019 Apr 23; 145(10). PMID: 31008533    Free PMC article.
There Is Something Fishy About Liver Cancer: Zebrafish Models of Hepatocellular Carcinoma.
Paul J Wrighton, Isaac M Oderberg, Wolfram Goessling.
Cell Mol Gastroenterol Hepatol, 2019 May 21; 8(3). PMID: 31108233    Free PMC article.
Review.
Simvastatin induces breast cancer cell death through oxidative stress up-regulating miR-140-5p.
Fuliang Bai, Ze Yu, +3 authors, Feifei Liu.
Aging (Albany NY), 2019 May 30; 11(10). PMID: 31138773    Free PMC article.
Highly Cited.
Mitochondrial ncRNA targeting induces cell cycle arrest and tumor growth inhibition of MDA-MB-231 breast cancer cells through reduction of key cell cycle progression factors.
Christopher Fitzpatrick, Maximiliano F Bendek, +14 authors, Verónica A Burzio.
Cell Death Dis, 2019 May 31; 10(6). PMID: 31142736    Free PMC article.
Knockdown of TM9SF4 boosts ER stress to trigger cell death of chemoresistant breast cancer cells.
Yifei Zhu, Mingxu Xie, +6 authors, Xiaoqiang Yao.
Oncogene, 2019 Jun 30; 38(29). PMID: 31249383
The volumetric-tumour histogram-based analysis of intravoxel incoherent motion and non-Gaussian diffusion MRI: association with prognostic factors in HER2-positive breast cancer.
Chao You, Jianwei Li, +4 authors, Weijun Peng.
J Transl Med, 2019 Jul 03; 17(1). PMID: 31262334    Free PMC article.
Checkpoint Blockade Strategies in the Treatment of Breast Cancer: Where We Are and Where We Are Heading.
Jeremy Force, Jorge Henrique Santos Leal, Heather L McArthur.
Curr Treat Options Oncol, 2019 Mar 30; 20(4). PMID: 30923913
Review.
An Expanded Agenda for the Primary Prevention of Breast Cancer: Charting a Course for the Future.
Mary C White, Marion Mhel H E Kavanaugh-Lynch, Shauntay Davis-Patterson, Nancy Buermeyer.
Int J Environ Res Public Health, 2020 Jan 26; 17(3). PMID: 31979073    Free PMC article.
miR-15b-5p Promotes Growth and Metastasis in Breast Cancer by Targeting HPSE2.
Balu Wu, Guohong Liu, +6 authors, Yongchang Wei.
Front Oncol, 2020 Mar 17; 10. PMID: 32175269    Free PMC article.
Downregulation of GPSM2 is associated with primary resistance to paclitaxel in breast cancer.
Zhe Zhang, Zhi Li, +5 authors, Qingjie Lv.
Oncol Rep, 2020 Feb 06; 43(3). PMID: 32020211    Free PMC article.
Encapsulation of Variabilin in Stearic Acid Solid Lipid Nanoparticles Enhances Its Anticancer Activity in Vitro.
Mookho S Lerata, Sarah D'Souza, +5 authors, Denzil R Beukes.
Molecules, 2020 Feb 23; 25(4). PMID: 32074951    Free PMC article.
circGNB1 Facilitates Triple-Negative Breast Cancer Progression by Regulating miR-141-5p-IGF1R Axis.
Peng Liu, Yutian Zou, +5 authors, Yanan Kong.
Front Genet, 2020 Mar 21; 11. PMID: 32194644    Free PMC article.
Adverse effects of being underweight on young female breast cancer patients with lymph node metastases.
Bo Chen, Jianguo Lai, +4 authors, Ning Liao.
J Cancer, 2020 Mar 21; 11(7). PMID: 32194809    Free PMC article.
Performance of Computer-Aided Diagnosis in Ultrasonography for Detection of Breast Lesions Less and More Than 2 cm: Prospective Comparative Study.
Liang Yongping, Ping Zhou, +3 authors, Yifan Shi.
JMIR Med Inform, 2020 Mar 05; 8(3). PMID: 32130149    Free PMC article.
The Vascular Index of Superb Microvascular Imaging Can Improve the Diagnostic Accuracy for Breast Imaging Reporting and Data System Category 4 Breast Lesions.
Si-Man Cai, Hong-Yan Wang, +5 authors, Yu-Xin Jiang.
Cancer Manag Res, 2020 Mar 27; 12. PMID: 32210624    Free PMC article.
PIWI-interacting RNAs: new biomarkers for diagnosis and treatment of breast cancer.
Parisa Maleki Dana, Mohammad Ali Mansournia, Seyyed Mehdi Mirhashemi.
Cell Biosci, 2020 Mar 27; 10. PMID: 32211149    Free PMC article.
Review.
XIAOPI formula inhibits the pre-metastatic niche formation in breast cancer via suppressing TAMs/CXCL1 signaling.
Yifeng Zheng, Neng Wang, +5 authors, Zhiyu Wang.
Cell Commun Signal, 2020 Mar 28; 18(1). PMID: 32213179    Free PMC article.
Lapatinib in combination with capecitabine versus continued use of trastuzumab in breast cancer patients with trastuzumab-resistance: a retrospective study of a Chinese population.
Fan Yang, Xiang Huang, +17 authors, Zefei Jiang.
BMC Cancer, 2020 Apr 01; 20(1). PMID: 32223744    Free PMC article.
Targeting the ROS/PI3K/AKT/HIF-1α/HK2 axis of breast cancer cells: Combined administration of Polydatin and 2-Deoxy-d-glucose.
Tao Zhang, Xinying Zhu, +5 authors, Changwei Qiu.
J Cell Mol Med, 2019 Mar 29; 23(5). PMID: 30920152    Free PMC article.
Long non-coding RNA LINC00968 reduces cell proliferation and migration and angiogenesis in breast cancer through up-regulation of PROX1 by reducing hsa-miR-423-5p.
Xianfu Sun, Tao Huang, +4 authors, Zhenzhen Liu.
Cell cycle (Georgetown, Tex.), 2019 Jun 20; 18(16). PMID: 31213129    Free PMC article.
Dietary Compound Isoliquiritigenin, an Antioxidant from Licorice, Suppresses Triple-Negative Breast Tumor Growth via Apoptotic Death Program Activation in Cell and Xenograft Animal Models.
Po-Han Lin, Yi-Fen Chiang, +8 authors, Shih-Min Hsia.
Antioxidants (Basel), 2020 Mar 14; 9(3). PMID: 32164337    Free PMC article.
Adrenomedullin inhibits tumor metastasis and is associated with good prognosis in triple-negative breast cancer patients.
Li-Li Liu, Shi-Lu Chen, +5 authors, Rong-Zhen Luo.
Am J Transl Res, 2020 Apr 10; 12(3). PMID: 32269711    Free PMC article.
Everolimus versus alpelisib in advanced hormone receptor-positive HER2-negative breast cancer: targeting different nodes of the PI3K/AKT/mTORC1 pathway with different clinical implications.
Claudio Vernieri, Francesca Corti, +7 authors, Filippo de Braud.
Breast Cancer Res, 2020 Apr 08; 22(1). PMID: 32252811    Free PMC article.
Review.
Moderate Exercise Modulates Tumor Metabolism of Triple-Negative Breast Cancer.
Anderson Vulczak, Anderson de Oliveira Souza, +3 authors, Luciane Carla Alberici.
Cells, 2020 Mar 11; 9(3). PMID: 32151035    Free PMC article.
LncRNA MIR503HG inhibits cell migration and invasion via miR-103/OLFM4 axis in triple negative breast cancer.
Jia Fu, Guanjun Dong, +7 authors, Bin Xiong.
J Cell Mol Med, 2019 May 08; 23(7). PMID: 31062436    Free PMC article.
Prognostic nomogram based on immune scores for breast cancer patients.
Ju Wang, Yanling Li, +4 authors, Xiaowei Qi.
Cancer Med, 2019 Jul 26; 8(11). PMID: 31342666    Free PMC article.
Cone-beam breast CT features associated with HER2/neu overexpression in patients with primary breast cancer.
Yueqiang Zhu, Yuwei Zhang, +9 authors, Zhaoxiang Ye.
Eur Radiol, 2020 Jan 05; 30(5). PMID: 31900700
Ki-67 index, progesterone receptor expression, histologic grade and tumor size in predicting breast cancer recurrence risk: A consecutive cohort study.
Yanna Zhang, Yidong Zhou, +2 authors, Qiang Sun.
Cancer Commun (Lond), 2020 Apr 16; 40(4). PMID: 32291973    Free PMC article.
Inhibition of PI3K/AKT molecular pathway mediated by membrane estrogen receptor GPER accounts for cryptotanshinone induced antiproliferative effect on breast cancer SKBR-3 cells.
Danning Shi, Piwen Zhao, +4 authors, Meng Chen.
BMC Pharmacol Toxicol, 2020 May 03; 21(1). PMID: 32357920    Free PMC article.
Targeting ANXA1 abrogates Treg-mediated immune suppression in triple-negative breast cancer.
Fang Bai, Peng Zhang, +6 authors, Kejin Wu.
J Immunother Cancer, 2020 Apr 18; 8(1). PMID: 32300050    Free PMC article.
Metformin suppresses proliferation and invasion of drug-resistant breast cancer cells by activation of the Hippo pathway.
Jie Liu, Juan Li, +4 authors, Peijun Liu.
J Cell Mol Med, 2020 Apr 14; 24(10). PMID: 32281270    Free PMC article.
High Galectin-7 and Low Galectin-8 Expression and the Combination of both are Negative Prognosticators for Breast Cancer Patients.
Anna Trebo, Nina Ditsch, +8 authors, Anna Hester.
Cancers (Basel), 2020 Apr 16; 12(4). PMID: 32290551    Free PMC article.
Checking NEKs: Overcoming a Bottleneck in Human Diseases.
Andressa Peres de Oliveira, Luidy Kazuo Issayama, +4 authors, Jörg Kobarg.
Molecules, 2020 Apr 17; 25(8). PMID: 32294979    Free PMC article.
Review.
EHD2 is a Predictive Biomarker of Chemotherapy Efficacy in Triple Negative Breast Carcinoma.
Wei-Wei Shen, Ivan Bièche, +4 authors, Christophe Lamaze.
Sci Rep, 2020 May 16; 10(1). PMID: 32409676    Free PMC article.
Dysregulation of TLR2 Serves as a Prognostic Biomarker in Breast Cancer and Predicts Resistance to Endocrine Therapy in the Luminal B Subtype.
Yunmei Wang, Shuguang Liu, Yanjun Zhang, Jin Yang.
Front Oncol, 2020 May 20; 10. PMID: 32426275    Free PMC article.
The Effects of Pharmacological and Non-Pharmacological Interventions on Symptom Management and Quality of Life among Breast Cancer Survivors Undergoing Adjuvant Endocrine Therapy: A Systematic Review.
Carmen W H Chan, Daria Tai, +3 authors, Bernard M H Law.
Int J Environ Res Public Health, 2020 Apr 30; 17(8). PMID: 32344759    Free PMC article.
Systematic Review.
The Anti-Breast Cancer Effect and Mechanism of Glimepiride-Metformin Adduct.
Liangyuan Long, Xiangnan Hu, +6 authors, Weiying Zhou.
Onco Targets Ther, 2020 May 23; 13. PMID: 32440146    Free PMC article.
Evaluation of the Quadri-Planes Method in Computer-Aided Diagnosis of Breast Lesions by Ultrasonography: Prospective Single-Center Study.
Liang Yongping, Zhang Juan, +3 authors, Yifan Shi.
JMIR Med Inform, 2020 May 06; 8(5). PMID: 32369039    Free PMC article.
Current practice in mammographic imaging of the augmented breast in Australia.
Jacquelyn R O'Keefe, Jenny Maree Wilkinson, Kelly Maree Spuur.
J Med Radiat Sci, 2020 Jan 26; 67(2). PMID: 31981297    Free PMC article.
Integrative analysis of DNA methylation and gene expression profiles identified potential breast cancer-specific diagnostic markers.
Xinhua Liu, Yonglin Peng, Ju Wang.
Biosci Rep, 2020 May 16; 40(5). PMID: 32412047    Free PMC article.
SRPK1 acetylation modulates alternative splicing to regulate cisplatin resistance in breast cancer cells.
Cheng Wang, Zhihong Zhou, +5 authors, Qidong Hu.
Commun Biol, 2020 May 29; 3(1). PMID: 32461560    Free PMC article.
Combination cyclin-dependent kinase 4/6 inhibitors and endocrine therapy versus endocrine monotherapy for hormonal receptor-positive, human epidermal growth factor receptor 2-negative advanced breast cancer: A systematic review and meta-analysis.
Jiani Zheng, Jingxun Wu, +3 authors, Feng Ye.
PLoS One, 2020 Jun 05; 15(6). PMID: 32497134    Free PMC article.
Systematic Review.
Prognostic value of the systemic immune-inflammation index in patients with breast cancer: a meta-analysis.
Yantao Zhang, Yong Sun, Qiwen Zhang.
Cancer Cell Int, 2020 Jun 13; 20. PMID: 32528232    Free PMC article.
The Burden and Trends of Breast Cancer From 1990 to 2017 at the Global, Regional, and National Levels: Results From the Global Burden of Disease Study 2017.
Peng Ji, Yue Gong, +3 authors, Zhi-Ming Shao.
Front Oncol, 2020 Jun 13; 10. PMID: 32528870    Free PMC article.
Interleukin-31 Receptor α Is Required for Basal-Like Breast Cancer Progression.
Yanling He, Xinyuan Zhang, +3 authors, Jian Shi.
Front Oncol, 2020 Jun 13; 10. PMID: 32528891    Free PMC article.
Application of a Biphasic Mathematical Model of Cancer Cell Drug Response for Formulating Potent and Synergistic Targeted Drug Combinations to Triple Negative Breast Cancer Cells.
Jinyan Shen, Li Li, +2 authors, Gongqin Sun.
Cancers (Basel), 2020 May 01; 12(5). PMID: 32349331    Free PMC article.
HER2-targeted therapy influences CTC status in metastatic breast cancer.
Thomas M Deutsch, Sabine Riethdorf, +9 authors, Markus Wallwiener.
Breast Cancer Res Treat, 2020 May 22; 182(1). PMID: 32436146    Free PMC article.
ESMO Management and treatment adapted recommendations in the COVID-19 era: Breast Cancer.
Evandro de Azambuja, Dario Trapani, +10 authors, Giuseppe Curigliano.
ESMO Open, 2020 May 23; 5(Suppl 3). PMID: 32439716    Free PMC article.
Review.
Vitamin D in Triple-Negative and BRCA1-Deficient Breast Cancer-Implications for Pathogenesis and Therapy.
Janusz Blasiak, Elzbieta Pawlowska, +3 authors, Cezary Chojnacki.
Int J Mol Sci, 2020 May 28; 21(10). PMID: 32456160    Free PMC article.
Review.
Pharmacological Modulation of Steroid Activity in Hormone-Dependent Breast and Prostate Cancers: Effect of Some Plant Extract Derivatives.
Bagora Bayala, Abdou Azaque Zoure, +3 authors, Jean-Marc A Lobaccaro.
Int J Mol Sci, 2020 May 28; 21(10). PMID: 32456259    Free PMC article.
Review.
Macrophage-cancer hybrid membrane-coated nanoparticles for targeting lung metastasis in breast cancer therapy.
Chunai Gong, Xiaoyan Yu, +6 authors, Yongfang Yuan.
J Nanobiotechnology, 2020 Jun 18; 18(1). PMID: 32546174    Free PMC article.
ZNF367-induced transcriptional activation of KIF15 accelerates the progression of breast cancer.
Huijuan Zeng, Tianfu Li, +5 authors, Ying Lin.
Int J Biol Sci, 2020 Jun 19; 16(12). PMID: 32549756    Free PMC article.
Low-dose metronomic chemotherapy as an efficient treatment option in metastatic breast cancer-results of an exploratory case-control study.
S Krajnak, C Schnatz, +9 authors, M J Battista.
Breast Cancer Res Treat, 2020 Jun 05; 182(2). PMID: 32495001    Free PMC article.
β-Blocker use is not associated with improved clinical outcomes in women with breast cancer: a meta-analysis.
Chaoran Li, Tian Li, +2 authors, Weihong Zhang.
Biosci Rep, 2020 May 22; 40(6). PMID: 32436935    Free PMC article.
Prognostic characterization of OAS1/OAS2/OAS3/OASL in breast cancer.
Yujie Zhang, Chaoran Yu.
BMC Cancer, 2020 Jun 21; 20(1). PMID: 32560641    Free PMC article.
Long non-coding RNA SNHG22 facilitates the malignant phenotypes in triple-negative breast cancer via sponging miR-324-3p and upregulating SUDS3.
Xuan Fang, Jin Zhang, +3 authors, Peng Zhou.
Cancer Cell Int, 2020 Jun 23; 20. PMID: 32565736    Free PMC article.
Inhibition of JK184-Induced Cytoprotective Autophagy Potentiates JK184 Antitumor Effects in Breast Cancer.
Xiaoya Xi, Tao He.
J Oncol, 2020 Jun 23; 2020. PMID: 32565796    Free PMC article.
Effect of COL4A1 Expression on the Survival of Neoadjuvant Chemotherapy Breast Cancer Patients.
Shin-Mae Wang, Po-Ming Chen, +3 authors, Pei-Yi Chu.
J Oncol, 2020 Jun 23; 2020. PMID: 32565804    Free PMC article.
Correlation of sex-determining region Y-box 30 with tumor characteristics and its prognostic value in breast cancer.
Hui Peng, Yang Luo, Jing Wu, Wanling Yin.
J Clin Lab Anal, 2020 Mar 12; 34(6). PMID: 32157740    Free PMC article.
Quality of Life of Women with Breast Cancer and Socio-Demographic Factors.
Magdalena Konieczny, Elżbieta Cipora, Katarzyna Sygit, Andrzej Fal.
Asian Pac J Cancer Prev, 2020 Jan 28; 21(1). PMID: 31983183    Free PMC article.
Relative Survival Benefit by Hormonal Receptor Status of Adding Trastuzumab to Neoadjuvant Chemotherapy in Breast Cancer Patients.
Jean Schneider, Hyouk Jin Lee, +6 authors, Hongki Gwak.
J Breast Cancer, 2020 Jul 01; 23(3). PMID: 32595988    Free PMC article.
Diagnosis, Prognosis, and Management of Breast Cancer in an 81-Year-Old Male Patient.
Jimmy George, Audrey Albach, +2 authors, Quan D Nguyen.
Cureus, 2020 Jul 01; 12(5). PMID: 32601553    Free PMC article.
High levels of KLK7 protein expression are related to a favorable prognosis in triple-negative breast cancer patients.
Xiaocong Geng, Lamiya Babayeva, +7 authors, Julia Dorn.
Am J Cancer Res, 2020 Jul 10; 10(6). PMID: 32642290    Free PMC article.
CircMMP11 acts as a ce-circRNA in breast cancer progression by regulating miR-1204.
Zehuan Li, Zhanghan Chen, +2 authors, Ying Jiang.
Am J Transl Res, 2020 Jul 14; 12(6). PMID: 32655792    Free PMC article.
Breast Cancer Chemotherapeutic Options: A General Overview on the Preclinical Validation of a Multi-Target Ruthenium(III) Complex Lodged in Nucleolipid Nanosystems.
Maria Grazia Ferraro, Marialuisa Piccolo, +6 authors, Carlo Irace.
Cells, 2020 Jun 11; 9(6). PMID: 32517101    Free PMC article.
Review.
Long Noncoding RNAs Involved in the Endocrine Therapy Resistance of Breast Cancer.
Toshihiko Takeiwa, Kazuhiro Ikeda, +2 authors, Satoshi Inoue.
Cancers (Basel), 2020 Jun 04; 12(6). PMID: 32486413    Free PMC article.
Review.
EP3 Is an Independent Prognostic Marker Only for Unifocal Breast Cancer Cases.
Alaleh Zati Zehni, Udo Jeschke, +7 authors, Theresa Vilsmaier.
Int J Mol Sci, 2020 Jun 26; 21(12). PMID: 32580276    Free PMC article.
A Novel Circular RNA hsa_circRPPH1_015 Exerts an Oncogenic Role in Breast Cancer by Impairing miRNA-326-Mediated ELK1 Inhibition.
Chunming Zhao, Linlin Li, +5 authors, Rui Jiang.
Front Oncol, 2020 Jul 17; 10. PMID: 32670874    Free PMC article.
Exercise for fatigue in breast cancer patients: An umbrella review of systematic reviews.
Mengyao Jiang, Yuxia Ma, +3 authors, Lin Han.
Int J Nurs Sci, 2020 Jul 21; 7(2). PMID: 32685623    Free PMC article.
Review.
Circular RNA La-related RNA-binding protein 4 correlates with reduced tumor stage, as well as better prognosis, and promotes chemosensitivity to doxorubicin in breast cancer.
Xiaoyi Zhang, Xinyu Su, +2 authors, Xun Li.
J Clin Lab Anal, 2020 Mar 19; 34(7). PMID: 32187743    Free PMC article.
ESM-1 Overexpression is Involved in Increased Tumorigenesis of Radiotherapy-Resistant Breast Cancer Cells.
Hana Jin, Trojan Rugira, +3 authors, Hye Jung Kim.
Cancers (Basel), 2020 May 30; 12(6). PMID: 32466580    Free PMC article.
Computer-Aided Ligand Discovery for Estrogen Receptor Alpha.
Divya Bafna, Fuqiang Ban, +2 authors, Artem Cherkasov.
Int J Mol Sci, 2020 Jun 18; 21(12). PMID: 32545494    Free PMC article.
Review.
Coordinate β-adrenergic inhibition of mitochondrial activity and angiogenesis arrest tumor growth.
Cristina Nuevo-Tapioles, Fulvio Santacatterina, +4 authors, José M Cuezva.
Nat Commun, 2020 Jul 19; 11(1). PMID: 32681016    Free PMC article.
CXCR4 Antagonist AMD3100 Reverses the Resistance to Tamoxifen in Breast Cancer via Inhibiting AKT Phosphorylation.
Jun Zhou, Kehao Le, +7 authors, Tao Huang.
Mol Ther Oncolytics, 2020 Jul 22; 18. PMID: 32691010    Free PMC article.
The identification of candidate effective combination regimens for pancreatic cancer using the histoculture drug response assay.
Eunsung Jun, Yejong Park, +9 authors, Song Cheol Kim.
Sci Rep, 2020 Jul 21; 10(1). PMID: 32686712    Free PMC article.
Longitudinal HER2 amplification tracked in circulating tumor DNA for therapeutic effect monitoring and prognostic evaluation in patients with breast cancer.
Xiuwen Guan, Binliang Liu, +9 authors, Fei Ma.
Breast, 2020 Jan 14; 49. PMID: 31927339    Free PMC article.
Safety and efficacy of sirolimus combined with endocrine therapy in patients with advanced hormone receptor-positive breast cancer and the exploration of biomarkers.
Zongbi Yi, Binliang Liu, +10 authors, Binghe Xu.
Breast, 2020 Apr 27; 52. PMID: 32335491    Free PMC article.
Ambiguous roles and potential therapeutic strategies of innate lymphoid cells in different types of tumor.
Shijie Wang, Pin Wu, Yongyuan Chen, Ying Chai.
Oncol Lett, 2020 Jul 30; 20(2). PMID: 32724393    Free PMC article.
Review.
Flubendazole elicits anti-cancer effects via targeting EVA1A-modulated autophagy and apoptosis in Triple-negative Breast Cancer.
Yongqi Zhen, Rongyan Zhao, +5 authors, Xian-Li Zhou.
Theranostics, 2020 Jul 30; 10(18). PMID: 32724459    Free PMC article.
Combination of Detoxified Pneumolysin Derivative ΔA146Ply and Berbamine as a Treatment Approach for Breast Cancer.
Hong Zhang, Tao Zhu, +8 authors, Xuemei Zhang.
Mol Ther Oncolytics, 2020 Jul 31; 18. PMID: 32728613    Free PMC article.
IL-22 promotes tumor growth of breast cancer cells in mice.
Ying Zhang, Cong Liu, +4 authors, Bin Pan.
Aging (Albany NY), 2020 Jul 11; 12(13). PMID: 32649314    Free PMC article.
A DNA Methylation-Based Panel for the Prognosis and Dagnosis of Patients With Breast Cancer and Its Mechanisms.
Xiao-Ping Liu, Jinxuan Hou, +3 authors, Sheng Li.
Front Mol Biosci, 2020 Aug 01; 7. PMID: 32733914    Free PMC article.
Ectodermal-neural cortex 1 as a novel biomarker predicts poor prognosis and induces metastasis in breast cancer by promoting Wnt/β-catenin pathway.
Yuhui Zhou, Xiaojiang Tang, +3 authors, Jianjun He.
J Cell Mol Med, 2020 Jul 04; 24(15). PMID: 32618411    Free PMC article.
Patterns of Chest Wall Recurrence and Suggestions on the Clinical Target Volume of Breast Cancer: A Retrospective Analysis of 121 Postmastectomy Patients.
Lin-Wei Wang, Li Li, +2 authors, Ya-Hua Zhong.
Cancer Manag Res, 2020 Aug 09; 12. PMID: 32765092    Free PMC article.
Circulating Tumor Cells in Metastatic Breast Cancer: From Genome Instability to Metastasis.
Ekaterina Ivanova, Ambber Ward, Adrian P Wiegmans, Derek John Richard.
Front Mol Biosci, 2020 Aug 09; 7. PMID: 32766277    Free PMC article.
Review.
Strategies to enable large-scale proteomics for reproducible research.
Rebecca C Poulos, Peter G Hains, +24 authors, Qing Zhong.
Nat Commun, 2020 Aug 01; 11(1). PMID: 32732981    Free PMC article.
Fibrinogen-Like Protein 2 (FGL2) is a Novel Biomarker for Clinical Prediction of Human Breast Cancer.
Yanyan Feng, Chunguang Guo, +6 authors, Guangrui Huang.
Med Sci Monit, 2020 Jul 28; 26. PMID: 32716910    Free PMC article.
How shall we treat locally advanced triple negative breast cancer?
Paulo Luz, David Dias, +2 authors, Beatriz Gosalbez.
F1000Res, 2020 Aug 21; 8. PMID: 32802311    Free PMC article.
WNT signaling pathway regulator-FRAT2 affects oncogenesis and prognosis of basal-like breast cancer.
Yao Zhou, Can Li, +5 authors, Taiyuan Li.
J Thorac Dis, 2020 Aug 18; 12(7). PMID: 32802426    Free PMC article.
RelB sustains endocrine resistant malignancy: an insight of noncanonical NF-κB pathway into breast Cancer progression.
Mei Wang, Yanyan Zhang, +7 authors, Jinhai Tang.
Cell Commun Signal, 2020 Aug 19; 18(1). PMID: 32807176    Free PMC article.
Clinical implications of prospective genomic profiling of metastatic breast cancer patients.
Courtney T van Geelen, Peter Savas, +11 authors, Sherene Loi.
Breast Cancer Res, 2020 Aug 20; 22(1). PMID: 32811538    Free PMC article.
CircRNA inhibits DNA damage repair by interacting with host gene.
Xiaolong Xu, Jingwei Zhang, +9 authors, Lei Wei.
Mol Cancer, 2020 Aug 26; 19(1). PMID: 32838810    Free PMC article.
Iron(II) phthalocyanine Loaded and AS1411 Aptamer Targeting Nanoparticles: A Nanocomplex for Dual Modal Imaging and Photothermal Therapy of Breast Cancer.
Yubei He, Mengzhu Wang, +7 authors, Gengbiao Yuan.
Int J Nanomedicine, 2020 Aug 28; 15. PMID: 32848397    Free PMC article.
Dietary intervention, a promising adjunct for cancer therapy.
Rongchen Shi, Hongming Miao.
Signal Transduct Target Ther, 2020 Aug 26; 5(1). PMID: 32839431    Free PMC article.
Comprehensive Analysis of LincRNAs in Classical and Basal-Like Subtypes of Pancreatic Cancer.
Markus Glaß, Agnes Dorn, +2 authors, Tony Gutschner.
Cancers (Basel), 2020 Jul 31; 12(8). PMID: 32727085    Free PMC article.
The Biology of Exosomes in Breast Cancer Progression: Dissemination, Immune Evasion and Metastatic Colonization.
Cinzia Giordano, Giusi La Camera, +4 authors, Stefania Catalano.
Cancers (Basel), 2020 Aug 09; 12(8). PMID: 32764376    Free PMC article.
Review.
Integral membrane protein 2A inhibits cell growth in human breast cancer via enhancing autophagy induction.
Cefan Zhou, Ming Wang, +3 authors, Jingfeng Tang.
Cell Commun Signal, 2019 Aug 24; 17(1). PMID: 31438969    Free PMC article.
RP11-480I12.5-004 Promotes Growth and Tumorigenesis of Breast Cancer by Relieving miR-29c-3p-Mediated AKT3 and CDK6 Degradation.
Weiyang Lou, Bisha Ding, +3 authors, Peifen Fu.
Mol Ther Nucleic Acids, 2020 Aug 19; 21. PMID: 32810693    Free PMC article.
Tearable and Fillable Composite Sponges Capable of Heat Generation and Drug Release in Response to Alternating Magnetic Field.
Koichiro Hayashi, Atsuto Tokuda, +2 authors, Chikara Ohtsuki.
Materials (Basel), 2020 Aug 23; 13(16). PMID: 32824485    Free PMC article.
Efficacy and safety of Xiaoaiping injection for breast cancer: A protocol for systematic review and meta-analysis.
Daorui Hou, Jian Xiong, +2 authors, Lu Xiong.
Medicine (Baltimore), 2020 Sep 03; 99(35). PMID: 32871934    Free PMC article.
Malic Enzyme 1 Indicates Worse Prognosis in Breast Cancer and Promotes Metastasis by Manipulating Reactive Oxygen Species.
Chang Liu, Jun Cao, +4 authors, Xichun Hu.
Onco Targets Ther, 2020 Sep 15; 13. PMID: 32922044    Free PMC article.
Down-regulation of FOS-like antigen 1 enhances drug sensitivity in breast cancer.
Lingdi Duan, Min Zhao, +6 authors, Wei Dong.
Int J Clin Exp Pathol, 2020 Sep 15; 13(8). PMID: 32922605    Free PMC article.
Managing therapeutic resistance in breast cancer: from the lncRNAs perspective.
Liyuan Peng, Jingwen Jiang, +3 authors, Na Xie.
Theranostics, 2020 Sep 16; 10(23). PMID: 32929354    Free PMC article.
Review.
The efficacy of first-line chemotherapy in endocrine-resistant hormone receptor-positive (HR+), human epidermal growth factor receptor 2-negative (HER2-) metastatic breast cancer.
Sudpreeda Chainitikun, James P Long, +4 authors, Naoto T Ueno.
Breast Cancer Res Treat, 2020 Jul 29; 183(3). PMID: 32720114    Free PMC article.
An individual reference limit of the serum CEA-TPA-CA 15-3 tumor marker panel in the surveillance of asymptomatic women following surgery for primary breast cancer.
Andrea Nicolini, Angelo Carpi, +4 authors, Michael J Duffy.
Cancer Manag Res, 2018 Dec 28; 10. PMID: 30588093    Free PMC article.
Facets of Communication: Gap Junction Ultrastructure and Function in Cancer Stem Cells and Tumor Cells.
Anja Beckmann, Nadine Hainz, Thomas Tschernig, Carola Meier.
Cancers (Basel), 2019 Mar 03; 11(3). PMID: 30823688    Free PMC article.
Review.
Thyronamine regulation of TAAR1 expression in breast cancer cells and investigation of its influence on viability and migration.
Eileen Tremmel, Simone Hofmann, +10 authors, Aurelia Vattai.
Breast Cancer (Dove Med Press), 2019 Mar 13; 11. PMID: 30858725    Free PMC article.
The antiestrogenic effects of black cohosh on BRCA1 and steroid receptors in breast cancer cells.
Michael Crone, Kelly Hallman, +4 authors, Sumi Dinda.
Breast Cancer (Dove Med Press), 2019 Mar 13; 11. PMID: 30858726    Free PMC article.
Caveolin-1: a multifaceted driver of breast cancer progression and its application in clinical treatment.
Xian-Ling Qian, Yi-Hang Pan, +4 authors, Li-Xia Xiong.
Onco Targets Ther, 2019 Mar 19; 12. PMID: 30881011    Free PMC article.
Review.
Integrated Somatic and Germline Whole-Exome Sequencing Analysis in Women with Lung Cancer after a Previous Breast Cancer.
Simona Coco, Silvia Bonfiglio, +17 authors, Francesco Grossi.
Cancers (Basel), 2019 Mar 31; 11(4). PMID: 30925779    Free PMC article.
Effect of 21-gene recurrence score in decision-making for surgery in early stage breast cancer.
San-Gang Wu, Wen-Wen Zhang, +3 authors, Zhen-Yu He.
Onco Targets Ther, 2019 Apr 10; 12. PMID: 30962690    Free PMC article.
Tumor location of the central and nipple portion is associated with impaired survival for women with breast cancer.
Fei Ji, Wei-Kai Xiao, +10 authors, Kun Wang.
Cancer Manag Res, 2019 May 02; 11. PMID: 31040717    Free PMC article.
Targeting Palbociclib-Resistant Estrogen Receptor-Positive Breast Cancer Cells via Oncolytic Virotherapy.
Nadiia Lypova, Lilibeth Lanceta, +6 authors, Yoannis Imbert-Fernandez.
Cancers (Basel), 2019 May 19; 11(5). PMID: 31100952    Free PMC article.
Emerging Fluorescent Molecular Tracers to Guide Intra-Operative Surgical Decision-Making.
Pieterjan Debie, Sophie Hernot.
Front Pharmacol, 2019 May 30; 10. PMID: 31139085    Free PMC article.
Review.
Characterization of frequently mutated cancer genes in Chinese breast tumors: a comparison of Chinese and TCGA cohorts.
Guochun Zhang, Yulei Wang, +20 authors, Ning Liao.
Ann Transl Med, 2019 Jun 07; 7(8). PMID: 31168460    Free PMC article.
Epigenetic IVD Tests for Personalized Precision Medicine in Cancer.
Jesús Beltrán-García, Rebeca Osca-Verdegal, Salvador Mena-Mollá, José Luis García-Giménez.
Front Genet, 2019 Jul 19; 10. PMID: 31316555    Free PMC article.
Review.
TUFT1 Promotes Triple Negative Breast Cancer Metastasis, Stemness, and Chemoresistance by Up-Regulating the Rac1/β-Catenin Pathway.
Weiguang Liu, Guanglei Chen, +6 authors, Bo Chen.
Front Oncol, 2019 Jul 25; 9. PMID: 31338333    Free PMC article.
Avoidable Cancer Mortality in Germany Since Reunification: Regional Variation and Sex Differences.
Ronny Westerman, Michael Mühlichen.
Front Public Health, 2019 Jul 30; 7. PMID: 31355174    Free PMC article.
Association between circulating tumor cells and peripheral blood monocytes in metastatic breast cancer.
Ugo De Giorgi, Michal Mego, +7 authors, James M Reuben.
Ther Adv Med Oncol, 2019 Aug 28; 11. PMID: 31452692    Free PMC article.
Combined high expression of CD47 and CD68 is a novel prognostic factor for breast cancer patients.
Jingping Yuan, Huihua He, +3 authors, Honglin Yan.
Cancer Cell Int, 2019 Sep 19; 19. PMID: 31528120    Free PMC article.
Network-based approach to identify biomarkers predicting response and prognosis for HER2-negative breast cancer treatment with taxane-anthracycline neoadjuvant chemotherapy.
Cui Jiang, Shuo Wu, +5 authors, Tao Sun.
PeerJ, 2019 Sep 20; 7. PMID: 31534839    Free PMC article.
Estrogen Induces Selective Transcription of Caveolin1 Variants in Human Breast Cancer through Estrogen Responsive Element-Dependent Mechanisms.
Antonella Romano, Antonia Feola, +6 authors, Candida Zuchegna.
Int J Mol Sci, 2020 Aug 23; 21(17). PMID: 32825330    Free PMC article.
[Preparation of warangalone-loaded liposomes and its inhibitory effect on breast cancer cells].
Lianzhi Mao, Huiping Liu, +4 authors, Suxia Sun.
Nan Fang Yi Ke Da Xue Xue Bao, 2020 Sep 09; 40(6). PMID: 32895205    Free PMC article.
Celastrol Inhibits Migration and Invasion of Triple-Negative Breast Cancer Cells by Suppressing Interleukin-6 via Downregulating Nuclear Factor-κB (NF-κB).
Fei Yan, Zihong Wu, Zihui Li, Li Liu.
Med Sci Monit, 2020 Sep 14; 26. PMID: 32920591    Free PMC article.
Whole-exome sequencing of 79 xenografts as a potential approach for the identification of genetic variants associated with sensitivity to cytotoxic anticancer drugs.
Chihiro Udagawa, Yasushi Sasaki, +5 authors, Hitoshi Zembutsu.
PLoS One, 2020 Sep 29; 15(9). PMID: 32986753    Free PMC article.
Novel insights on targeting ferroptosis in cancer therapy.
Sipeng Zuo, Jie Yu, Hui Pan, Linna Lu.
Biomark Res, 2020 Oct 08; 8. PMID: 33024562    Free PMC article.
Review.
Molecular phenotype discordance between primary and synchronous metastatic lesions of breast cancer and its determinant role in guiding treatment decisions: a case report.
Jing-Hao Yao, Wu-Qiong Zhang, +4 authors, Yan Yang.
Am J Transl Res, 2020 Oct 13; 12(9). PMID: 33042465    Free PMC article.
Transcriptome-Based Network Analysis Unveils Eight Immune-Related Genes as Molecular Signatures in the Immunomodulatory Subtype of Triple-Negative Breast Cancer.
Jinguo Zhang, Li Wang, +4 authors, Guoxiong Xu.
Front Oncol, 2020 Oct 13; 10. PMID: 33042828    Free PMC article.
Development and validation of an LC-MS/MS method for simultaneous quantification of co-administered trastuzumab and pertuzumab.
Sandor Schokker, Fabrizia Fusetti, +3 authors, Hanneke W M van Laarhoven.
MAbs, 2020 Aug 04; 12(1). PMID: 32744170    Free PMC article.
MiR-548c-3p inhibits the proliferation, migration and invasion of human breast cancer cell by targeting E2F3.
Pei-Yi Tan, Liu-Jing Wen, Hua-Nan Li, Shi-Wei Chai.
Cytotechnology, 2020 Sep 10; 72(5). PMID: 32902720    Free PMC article.
Circulating MicroRNAs as Prognostic and Therapeutic Biomarkers in Breast Cancer Molecular Subtypes.
Veronica Zelli, Chiara Compagnoni, +7 authors, Edoardo Alesse.
J Pers Med, 2020 Aug 28; 10(3). PMID: 32842653    Free PMC article.
Review.
In Situ Metabolic Characterisation of Breast Cancer and Its Potential Impact on Therapy.
Gábor Petővári, Titanilla Dankó, +10 authors, Anna Sebestyén.
Cancers (Basel), 2020 Sep 10; 12(9). PMID: 32899149    Free PMC article.
Potent antitumor activity of cepharanthine against triple-negative breast cancer spheroids compared with tetrandrine.
Anna Kiyomi, Risako Miyakawa, +5 authors, Munetoshi Sugiura.
Oncol Lett, 2020 Oct 27; 20(6). PMID: 33101499    Free PMC article.
The Signaling Duo CXCL12 and CXCR4: Chemokine Fuel for Breast Cancer Tumorigenesis.
Karolina A Zielińska, Vladimir L Katanaev.
Cancers (Basel), 2020 Oct 25; 12(10). PMID: 33096815    Free PMC article.
Review.
Assessment of the WAP-Myc mouse mammary tumor model for spontaneous metastasis.
Begüm Utz, Rita Turpin, +2 authors, Juha Klefström.
Sci Rep, 2020 Nov 01; 10(1). PMID: 33127915    Free PMC article.
Association Between Statin Use and Prognosis of Breast Cancer: A Meta-Analysis of Cohort Studies.
Hui Lv, Ding Shi, +5 authors, Peiying Hu.
Front Oncol, 2020 Nov 13; 10. PMID: 33178584    Free PMC article.
Systematic Review.
Current Targets and Bioconjugation Strategies in Photodynamic Diagnosis and Therapy of Cancer.
Salvador Gomez, Allan Tsung, Zhiwei Hu.
Molecules, 2020 Oct 31; 25(21). PMID: 33121022    Free PMC article.
Review.
Oncotype DX Breast Recurrence Score Distribution and Chemotherapy Benefit Among Women of Different Age Groups With HR-Positive, HER2-Negative, Node-Negative Breast Cancer in the SEER Database.
Ran Cheng, Xiangyi Kong, +2 authors, Jing Wang.
Front Oncol, 2020 Nov 17; 10. PMID: 33194568    Free PMC article.
ZLM-7 inhibits the occurrence and angiogenesis of breast cancer through miR-212-3p/Sp1/VEGFA signal axis.
Xuan Li, Zi-Zheng Zou, +7 authors, Zhi-Yong Luo.
Mol Med, 2020 Nov 15; 26(1). PMID: 33187481    Free PMC article.
Identification of long-term survival-associated gene in breast cancer.
Shipeng Ning, Hui Li, +10 authors, Da Pang.
Aging (Albany NY), 2020 Oct 21; 12(20). PMID: 33080569    Free PMC article.