Journal Article
. 2017 Jan;35(2).
doi: 10.1080/07357907.2016.1267740.

Can Diffusion-Weighted Imaging and Related Apparent Diffusion Coefficient be a Prognostic Value in Women With Breast Cancer?

Paola Rabasco 1 Rocchina Caivano 2 Vittorio Simeon 3 Giuseppina Dinardo 1 Antonella Lotumolo 1 Matilde Gioioso 1 Antonio Villonio 1 Giancarlo Iannelli 1 Felice D'Antuono 1 Alexis Zandolino 1 Luca Macarini 4 Giuseppe Guglielmi 4 Aldo Cammarota 1 
Affiliations
  • PMID: 28107084
  •     8 citations

Abstract

Purpose: To analyze diffusion-weighted imaging (DWI) and the related apparent diffusion coefficient (ADC) in women with breast cancer, correlating these values with the presence at 3 years of distant metastases, and to demonstrate that DWI-Magnetic Resonance Imaging (MRI) and related ADC values may represent a prognostic value in the study of women with breast cancer.

Materials And Methods: Sixty women (aged 45-73 years) affected with breast cancer with a follow-up in 3 years were enrolled. On DWI, we obtained the ADC values, and these were correlated with the clinical condition of patients at 3 years. Moreover, tumour size, lymph node status, and molecular markers, including estrogens receptor, progesterone receptor, Ki-67 index, and human growth factor receptor 2 protein, were correlated with ADC values. This study was approved by the Scientific Committee of our institution.

Results: We considered patients with metastasis at 3 years (12 patients - 20%) and without metastasis (48 patients - 80%). The mean ADC value in patients with no metastases at 3 years was 1.06 ± 0.38, while for patients with metastases it was 0.74 ± 0.34 (p = .011). The receiver-operator curve analysis identified a value of 0.75 (<0.75 with risk to develop metastasis) as the best predictive cutoff for ADC values, with the highest sensitivity (81.25%) and higher specificity (66.67%). After regression analysis, ADC value, positivity to estrogen-progestin receptors, and presence of lymph nodes were the only prognostic factors found to be statistically significant.

Conclusions: DWI-MRI and related ADC values may represent a prognostic value in women with breast cancer.

Keywords: Breast cancer; apparent diffusion coefficient; diffusion-weighted imaging; magnetic resonance imaging; prognostic factors.

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