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doi: 10.1016/j.cell.2017.01.014.

Applications of Immunogenomics to Cancer

X Shirley Liu 1 Elaine R Mardis 2 
  • PMID: 28187283
  •     131 References
  •     67 citations


Cancer immunogenomics originally was framed by research supporting the hypothesis that cancer mutations generated novel peptides seen as "non-self" by the immune system. The search for these "neoantigens" has been facilitated by the combination of new sequencing technologies, specialized computational analyses, and HLA binding predictions that evaluate somatic alterations in a cancer genome and interpret their ability to produce an immune-stimulatory peptide. The resulting information can characterize a tumor's neoantigen load, its cadre of infiltrating immune cell types, the T or B cell receptor repertoire, and direct the design of a personalized therapeutic.

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