Review
. 2017 Feb; 168(4):644-656.
doi: 10.1016/j.cell.2017.01.002.

Endogenous DNA Damage as a Source of Genomic Instability in Cancer

Anthony Tubbs 1 André Nussenzweig 2 
Affiliations
  • PMID: 28187286
  •     94 References
  •     298 citations

Abstract

Genome instability, defined as higher than normal rates of mutation, is a double-edged sword. As a source of genetic diversity and natural selection, mutations are beneficial for evolution. On the other hand, genomic instability can have catastrophic consequences for age-related diseases such as cancer. Mutations arise either from inactivation of DNA repair pathways or in a repair-competent background due to genotoxic stress from celluar processes such as transcription and replication that overwhelm high-fidelity DNA repair. Here, we review recent studies that shed light on endogenous sources of mutation and epigenomic features that promote genomic instability during cancer evolution.

Keywords: DNA damage; DNA repair; DNA replication; Genome instability; cancer; mutagenesis; transcription.

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Activation of CaMKIIγ potentiates T-cell acute lymphoblastic leukemia leukemogenesis via phosphorylating FOXO3a.
Xudong Jiang, Zhaoxing Wu, +14 authors, Rongzhen Xu.
Oncotarget, 2017 Nov 02; 8(43). PMID: 29088844    Free PMC article.
Therapeutic targeting of PGBD5-induced DNA repair dependency in pediatric solid tumors.
Anton G Henssen, Casie Reed, +14 authors, Alex Kentsis.
Sci Transl Med, 2017 Nov 03; 9(414). PMID: 29093183    Free PMC article.
Molecular determinants of prostate cancer metastasis.
Kiera Rycaj, Dean G Tang.
Oncotarget, 2017 Nov 21; 8(50). PMID: 29152153    Free PMC article.
Review.
TDP2, TOP2, and SUMO: what is ZATT about?
Guido Zagnoli-Vieira, Keith W Caldecott.
Cell Res, 2017 Nov 22; 27(12). PMID: 29160298    Free PMC article.
DNA Damage Emanating From a Neutral Purine Radical Reveals the Sequence Dependent Convergence of the Direct and Indirect Effects of γ-Radiolysis.
Liwei Zheng, Marc M Greenberg.
J Am Chem Soc, 2017 Dec 01; 139(49). PMID: 29190086    Free PMC article.
The end-joining factor Ku acts in the end-resection of double strand break-free arrested replication forks.
Ana Teixeira-Silva, Anissia Ait Saada, +4 authors, Sarah A E Lambert.
Nat Commun, 2017 Dec 08; 8(1). PMID: 29215009    Free PMC article.
LncRNA lnc-RI regulates homologous recombination repair of DNA double-strand breaks by stabilizing RAD51 mRNA as a competitive endogenous RNA.
Liping Shen, Qi Wang, +4 authors, Zhidong Wang.
Nucleic Acids Res, 2017 Dec 08; 46(2). PMID: 29216366    Free PMC article.
HIV-1 Tat protein induces DNA damage in human peripheral blood B-lymphocytes via mitochondrial ROS production.
Rawan El-Amine, Diego Germini, +11 authors, Yegor S Vassetzky.
Redox Biol, 2017 Dec 09; 15. PMID: 29220699    Free PMC article.
Replication Stress Shapes a Protective Chromatin Environment across Fragile Genomic Regions.
Jeongkyu Kim, David Sturgill, +11 authors, Philipp Oberdoerffer.
Mol Cell, 2017 Dec 19; 69(1). PMID: 29249653    Free PMC article.
Family A and B DNA Polymerases in Cancer: Opportunities for Therapeutic Interventions.
Vinit Shanbhag, Shrikesh Sachdev, +2 authors, Kamalendra Singh.
Biology (Basel), 2018 Jan 06; 7(1). PMID: 29301327    Free PMC article.
Review.
Cytosolic HSC20 integrates de novo iron-sulfur cluster biogenesis with the CIAO1-mediated transfer to recipients.
Ki Soon Kim, Nunziata Maio, Anamika Singh, Tracey A Rouault.
Hum Mol Genet, 2018 Jan 09; 27(5). PMID: 29309586    Free PMC article.
AATF suppresses apoptosis, promotes proliferation and is critical for Kras-driven lung cancer.
Daniela Welcker, Manaswita Jain, +14 authors, Katja Höpker.
Oncogene, 2018 Jan 13; 37(11). PMID: 29321668
Main steps in DNA double-strand break repair: an introduction to homologous recombination and related processes.
Lepakshi Ranjha, Sean M Howard, Petr Cejka.
Chromosoma, 2018 Jan 13; 127(2). PMID: 29327130
Highly Cited. Review.
Maintenance of Genome Integrity by Mi2 Homologs CHD-3 and LET-418 in Caenorhabditis elegans.
Carolyn A Turcotte, Solomon A Sloat, +4 authors, Paula M Checchi.
Genetics, 2018 Jan 18; 208(3). PMID: 29339410    Free PMC article.
Caught with One's Zinc Fingers in the Genome Integrity Cookie Jar.
Caroline K Vilas, Lara E Emery, Eros Lazzerini Denchi, Kyle M Miller.
Trends Genet, 2018 Jan 27; 34(4). PMID: 29370947    Free PMC article.
Review.
Clonal Hematopoiesis and Evolution to Hematopoietic Malignancies.
Robert L Bowman, Lambert Busque, Ross L Levine.
Cell Stem Cell, 2018 Feb 06; 22(2). PMID: 29395053    Free PMC article.
Highly Cited. Review.
Missed cleavage opportunities by FEN1 lead to Okazaki fragment maturation via the long-flap pathway.
Manal S Zaher, Fahad Rashid, +5 authors, Samir M Hamdan.
Nucleic Acids Res, 2018 Feb 09; 46(6). PMID: 29420814    Free PMC article.
APOBEC-mediated mutagenesis in urothelial carcinoma is associated with improved survival, mutations in DNA damage response genes, and immune response.
Alexander P Glaser, Damiano Fantini, +5 authors, Joshua J Meeks.
Oncotarget, 2018 Feb 13; 9(4). PMID: 29435122    Free PMC article.
Co-exposure to environmental carcinogens in vivo induces neoplasia-related hallmarks in low-genotoxicity events, even after removal of insult.
Marta Martins, Ana Silva, +2 authors, Pedro M Costa.
Sci Rep, 2018 Feb 28; 8(1). PMID: 29483554    Free PMC article.
Investigating structure-property relationships of biomineralized calcium phosphate compounds as fluorescent quenching-recovery platform.
Liuzheng Wang, Xiang He, +3 authors, Ying Zhang.
R Soc Open Sci, 2018 Mar 09; 5(2). PMID: 29515827    Free PMC article.
Detecting Rare Mutations and DNA Damage with Sequencing-Based Methods.
Daniel B Sloan, Amanda K Broz, Joel Sharbrough, Zhiqiang Wu.
Trends Biotechnol, 2018 Mar 20; 36(7). PMID: 29550161    Free PMC article.
Review.
Response to "Unexpected mutations after CRISPR-Cas9 editing in vivo".
Reynald M Lescarbeau, Bradley Murray, Thomas M Barnes, Nessan Bermingham.
Nat Methods, 2018 Mar 31; 15(4). PMID: 29600988
Somatic POLE exonuclease domain mutations are early events in sporadic endometrial and colorectal carcinogenesis, determining driver mutational landscape, clonal neoantigen burden and immune response.
Daniel Temko, Inge C Van Gool, +23 authors, Ian Tomlinson.
J Pathol, 2018 Apr 01; 245(3). PMID: 29604063    Free PMC article.
Negative regulator of E2F transcription factors links cell cycle checkpoint and DNA damage repair.
Lili Wang, Hanchen Chen, +2 authors, Shunping Yan.
Proc Natl Acad Sci U S A, 2018 Apr 04; 115(16). PMID: 29610335    Free PMC article.
Genomic and Molecular Landscape of DNA Damage Repair Deficiency across The Cancer Genome Atlas.
Theo A Knijnenburg, Linghua Wang, +36 authors, Chen Wang.
Cell Rep, 2018 Apr 05; 23(1). PMID: 29617664    Free PMC article.
Highly Cited.
Endocrine disruptor exposure during development increases incidence of uterine fibroids by altering DNA repair in myometrial stem cells.
Lauren E Prusinski Fernung, Qiwei Yang, +3 authors, Ayman Al-Hendy.
Biol Reprod, 2018 Apr 25; 99(4). PMID: 29688260    Free PMC article.
Non-viral delivery systems for CRISPR/Cas9-based genome editing: Challenges and opportunities.
Ling Li, Shuo Hu, Xiaoyuan Chen.
Biomaterials, 2018 Apr 29; 171. PMID: 29704747    Free PMC article.
Highly Cited. Review.
Integrating the DNA damage and protein stress responses during cancer development and treatment.
Vassilis G Gorgoulis, Dafni-Eleftheria Pefani, Ioannis S Pateras, Ioannis P Trougakos.
J Pathol, 2018 May 15; 246(1). PMID: 29756349    Free PMC article.
Review.
Targeting Oxidatively Induced DNA Damage Response in Cancer: Opportunities for Novel Cancer Therapies.
Pierpaola Davalli, Gaetano Marverti, Angela Lauriola, Domenico D'Arca.
Oxid Med Cell Longev, 2018 May 18; 2018. PMID: 29770165    Free PMC article.
Review.
PAM-OBG: A monoamine oxidase B specific prodrug that inhibits MGMT and generates DNA interstrand crosslinks, potentiating temozolomide and chemoradiation therapy in intracranial glioblastoma.
Martyn A Sharpe, Sudhir Raghavan, David S Baskin.
Oncotarget, 2018 May 31; 9(35). PMID: 29844863    Free PMC article.
Fibroblasts in the Tumor Microenvironment: Shield or Spear?
Twana Alkasalias, Lidia Moyano-Galceran, Marie Arsenian-Henriksson, Kaisa Lehti.
Int J Mol Sci, 2018 Jun 09; 19(5). PMID: 29883428    Free PMC article.
Highly Cited. Review.
Gene promoter and exon DNA methylation changes in colon cancer development - mRNA expression and tumor mutation alterations.
Béla Molnár, Orsolya Galamb, +11 authors, Zsolt Tulassay.
BMC Cancer, 2018 Jun 28; 18(1). PMID: 29945573    Free PMC article.
Initiation of homologous recombination at DNA nicks.
Nancy Maizels, Luther Davis.
Nucleic Acids Res, 2018 Jul 10; 46(14). PMID: 29986051    Free PMC article.
Review.
Persistent Increased Frequency of Genomic Instability in Women Diagnosed with Breast Cancer: Before, during, and after Treatments.
Márcia Fernanda Correia Jardim Paz, André Luiz Pinho Sobral, +9 authors, Juliana da Silva.
Oxid Med Cell Longev, 2018 Jul 18; 2018. PMID: 30013718    Free PMC article.
Parvovirus minute virus of mice interacts with sites of cellular DNA damage to establish and amplify its lytic infection.
Kinjal Majumder, Juexin Wang, +4 authors, David J Pintel.
Elife, 2018 Jul 22; 7. PMID: 30028293    Free PMC article.
Genomics and Epigenetics of Malignant Mesothelioma.
Adam P Sage, Victor D Martinez, +8 authors, Wan L Lam.
High Throughput, 2018 Aug 01; 7(3). PMID: 30060501    Free PMC article.
Review.
Role of MCM2-7 protein phosphorylation in human cancer cells.
Liangru Fei, Hongtao Xu.
Cell Biosci, 2018 Aug 01; 8. PMID: 30062004    Free PMC article.
Review.
Genome-wide Map of R-Loop-Induced Damage Reveals How a Subset of R-Loops Contributes to Genomic Instability.
Lorenzo Costantino, Douglas Koshland.
Mol Cell, 2018 Aug 07; 71(4). PMID: 30078723    Free PMC article.
Highly Cited.
Single-Strand Break End Resection in Genome Integrity: Mechanism and Regulation by APE2.
Md Akram Hossain, Yunfeng Lin, Shan Yan.
Int J Mol Sci, 2018 Aug 17; 19(8). PMID: 30110897    Free PMC article.
Review.
How does inflammation drive mutagenesis in colorectal cancer?
Chia Wei Hsu, Mark L Sowers, +7 authors, Lawrence C Sowers.
Trends Cancer Res, 2017 Jan 01; 12. PMID: 30147278    Free PMC article.
Somatic mutation load and spectra: A record of DNA damage and repair in healthy human cells.
Natalie Saini, Dmitry A Gordenin.
Environ Mol Mutagen, 2018 Aug 29; 59(8). PMID: 30152078    Free PMC article.
Review.
SHLD2/FAM35A co-operates with REV7 to coordinate DNA double-strand break repair pathway choice.
Steven Findlay, John Heath, +24 authors, Alexandre Orthwein.
EMBO J, 2018 Aug 30; 37(18). PMID: 30154076    Free PMC article.
Highly Cited.
APOBEC3B Activity Is Prevalent in Urothelial Carcinoma Cells and Only Slightly Affected by LINE-1 Expression.
Ananda Ayyappan Jaguva Vasudevan, Ulrike Kreimer, +5 authors, Wolfgang Goering.
Front Microbiol, 2018 Sep 21; 9. PMID: 30233553    Free PMC article.
Multiple links connect central carbon metabolism to DNA replication initiation and elongation in Bacillus subtilis.
Hamid Nouri, Anne-Françoise Monnier, +8 authors, Laurent Janniere.
DNA Res, 2018 Sep 27; 25(6). PMID: 30256918    Free PMC article.
Mutagenic assessment of chemotherapy and Smac mimetic drugs in cells with defective DNA damage response pathways.
Mark A Miles, Christine J Hawkins.
Sci Rep, 2018 Sep 28; 8(1). PMID: 30258062    Free PMC article.
Bone morphogenetic protein signaling is required for RAD51-mediated maintenance of genome integrity in vascular endothelial cells.
Sanna Vattulainen-Collanus, Mark Southwood, +5 authors, Akiko Hata.
Commun Biol, 2018 Oct 03; 1. PMID: 30272025    Free PMC article.
Oxidative stress in sperm affects the epigenetic reprogramming in early embryonic development.
Sarah Wyck, Carolina Herrera, +4 authors, Raffaella Santoro.
Epigenetics Chromatin, 2018 Oct 20; 11(1). PMID: 30333056    Free PMC article.
DNA-PKcs promotes chromatin decondensation to facilitate initiation of the DNA damage response.
Huiming Lu, Janapriya Saha, +2 authors, Anthony J Davis.
Nucleic Acids Res, 2019 Aug 10; 47(18). PMID: 31396623    Free PMC article.
Nickel Carcinogenesis Mechanism: DNA Damage.
Hongrui Guo, Huan Liu, +7 authors, Ling Zhao.
Int J Mol Sci, 2019 Sep 25; 20(19). PMID: 31546657    Free PMC article.
Review.
The correlation of BER protein, IRF3 with CD8+ T cell and their prognostic significance in upper tract urothelial carcinoma.
Lin-Ang Wang, Bo Yang, +3 authors, Jun Jiang.
Onco Targets Ther, 2019 Oct 03; 12. PMID: 31576137    Free PMC article.
Regional Gene Repression by DNA Double-Strand Breaks in G1 Phase Cells.
Caitlin E Purman, Patrick L Collins, +4 authors, Eugene M Oltz.
Mol Cell Biol, 2019 Oct 09; 39(24). PMID: 31591143    Free PMC article.
Broken by the Cut: A Journey into the Role of Topoisomerase II in DNA Fragility.
Naomi D Atkin, Heather M Raimer, Yuh-Hwa Wang.
Genes (Basel), 2019 Oct 17; 10(10). PMID: 31614754    Free PMC article.
Review.
PIAS1 is not suitable as a urothelial carcinoma biomarker protein and pharmacological target.
Holger Hans Hermann Erb, Marlies Ebert, +4 authors, Eva Jüngel.
PLoS One, 2019 Oct 23; 14(10). PMID: 31639157    Free PMC article.
Fanconi-BRCA pathway mutations in childhood T-cell acute lymphoblastic leukemia.
Gayle P Pouliot, James Degar, +18 authors, Alejandro Gutierrez.
PLoS One, 2019 Nov 14; 14(11). PMID: 31721781    Free PMC article.
MDC1 PST-repeat region promotes histone H2AX-independent chromatin association and DNA damage tolerance.
Israel Salguero, Rimma Belotserkovskaya, +5 authors, Stephen P Jackson.
Nat Commun, 2019 Nov 16; 10(1). PMID: 31729360    Free PMC article.
Rpd3L and Hda1 histone deacetylases facilitate repair of broken forks by promoting sister chromatid cohesion.
Pedro Ortega, Belén Gómez-González, Andrés Aguilera.
Nat Commun, 2019 Nov 16; 10(1). PMID: 31729385    Free PMC article.
DNA Repair Footprint Uncovers Contribution of DNA Repair Mechanism to Mutational Signatures.
Damian Wojtowicz, Mark D M Leiserson, Roded Sharan, Teresa M Przytycka.
Pac Symp Biocomput, 2019 Dec 05; 25. PMID: 31797602    Free PMC article.
Type II DNA Topoisomerases Cause Spontaneous Double-Strand Breaks in Genomic DNA.
Suguru Morimoto, Masataka Tsuda, +3 authors, Shunichi Takeda.
Genes (Basel), 2019 Nov 02; 10(11). PMID: 31671674    Free PMC article.
Review.
Role of Focal Adhesion Kinase in Small-Cell Lung Cancer and Its Potential as a Therapeutic Target.
Frank Aboubakar Nana, Marie Vanderputten, Sebahat Ocak.
Cancers (Basel), 2019 Nov 02; 11(11). PMID: 31671774    Free PMC article.
Review.
Cell Death Response to DNA Damage.
Jean Y J Wang.
Yale J Biol Med, 2019 Dec 24; 92(4). PMID: 31866794    Free PMC article.
Review.
DNA repair fidelity in stem cell maintenance, health, and disease.
Chinnadurai Mani, P Hemachandra Reddy, Komaraiah Palle.
Biochim Biophys Acta Mol Basis Dis, 2019 Apr 07; 1866(4). PMID: 30953688    Free PMC article.
Review.
RAD51 is a potential marker for prognosis and regulates cell proliferation in pancreatic cancer.
Xiaomeng Zhang, Ningyi Ma, +2 authors, Zhigang Ren.
Cancer Cell Int, 2020 Jan 01; 19. PMID: 31889908    Free PMC article.
MicroRNA-140 impedes DNA repair by targeting FEN1 and enhances chemotherapeutic response in breast cancer.
Xiao Lu, Rui Liu, +5 authors, Zhigang Guo.
Oncogene, 2019 Sep 01; 39(1). PMID: 31471584
The Influence of (5'R)- and (5'S)-5',8-Cyclo-2'-Deoxyadenosine on UDG and hAPE1 Activity. Tandem Lesions are the Base Excision Repair System's Nightmare.
Bolesław T Karwowski.
Cells, 2019 Oct 28; 8(11). PMID: 31652769    Free PMC article.
Absence of XRCC4 and its paralogs in human cells reveal differences in outcomes for DNA repair and V(D)J recombination.
Brian Ruis, Amy Molan, Taylor Takasugi, Eric A Hendrickson.
DNA Repair (Amst), 2019 Nov 16; 85. PMID: 31731258    Free PMC article.
Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.
Jae Jin Kim, Seo Yun Lee, +10 authors, Kyle M Miller.
Genes Dev, 2019 Nov 23; 33(23-24). PMID: 31753913    Free PMC article.
Genomic analyses of flow-sorted Hodgkin Reed-Sternberg cells reveal complementary mechanisms of immune evasion.
Kirsty Wienand, Bjoern Chapuy, +19 authors, Margaret A Shipp.
Blood Adv, 2019 Dec 10; 3(23). PMID: 31816062    Free PMC article.
TNF-α G-308A genetic variants, serum CRP-hs concentration and DNA damage in obese women.
Marta Włodarczyk, Michał Ciebiera, Grażyna Nowicka.
Mol Biol Rep, 2019 Mar 23; 47(2). PMID: 30900134    Free PMC article.
A unique mutator phenotype reveals complementary oncogenic lesions leading to acute leukemia.
Mianmian Yin, Timour Baslan, +9 authors, Peter D Aplan.
JCI Insight, 2019 Oct 18; 4(23). PMID: 31622281    Free PMC article.
Chromosome arm aneuploidies shape tumour evolution and drug response.
Ankit Shukla, Thu H M Nguyen, +10 authors, Pascal H G Duijf.
Nat Commun, 2020 Jan 25; 11(1). PMID: 31974379    Free PMC article.
Interplay of Guanine Oxidation and G-Quadruplex Folding in Gene Promoters.
Aaron M Fleming, Cynthia J Burrows.
J Am Chem Soc, 2019 Dec 28; 142(3). PMID: 31880930    Free PMC article.
The genomics of oxidative DNA damage, repair, and resulting mutagenesis.
Anna R Poetsch.
Comput Struct Biotechnol J, 2020 Jan 30; 18. PMID: 31993111    Free PMC article.
Review.
Cops5 safeguards genomic stability of embryonic stem cells through regulating cellular metabolism and DNA repair.
Peng Li, Lulu Gao, +3 authors, Lingyi Chen.
Proc Natl Acad Sci U S A, 2020 Jan 23; 117(5). PMID: 31964807    Free PMC article.
Hallmarks of ribosomopathies.
Kim R Kampen, Sergey O Sulima, Stijn Vereecke, Kim De Keersmaecker.
Nucleic Acids Res, 2019 Jul 28; 48(3). PMID: 31350888    Free PMC article.
Review.
Breakage-Fusion-Bridge Events Trigger Complex Genome Rearrangements and Amplifications in Developmentally Arrested T Cell Lymphomas.
Joy J Bianchi, Valentine Murigneux, +2 authors, Ludovic Deriano.
Cell Rep, 2019 Jun 06; 27(10). PMID: 31167132    Free PMC article.
A novel DNA damage response signature of IDH-mutant grade II and grade III astrocytoma at transcriptional level.
Qi Liu, Kuanyu Wang, +4 authors, Pei Yang.
J Cancer Res Clin Oncol, 2020 Feb 16; 146(3). PMID: 32060643
Clustered DNA Double-Strand Breaks: Biological Effects and Relevance to Cancer Radiotherapy.
Jac A Nickoloff, Neelam Sharma, Lynn Taylor.
Genes (Basel), 2020 Jan 19; 11(1). PMID: 31952359    Free PMC article.
Review.
APE1 senses DNA single-strand breaks for repair and signaling.
Yunfeng Lin, Jude Raj, +5 authors, Shan Yan.
Nucleic Acids Res, 2019 Dec 13; 48(4). PMID: 31828326    Free PMC article.
A Sticky Multinomial Mixture Model of Strand-Coordinated Mutational Processes in Cancer.
Itay Sason, Damian Wojtowicz, +3 authors, Roded Sharan.
iScience, 2020 Feb 24; 23(3). PMID: 32088392    Free PMC article.
A universal fluorescence-based toolkit for real-time quantification of DNA and RNA nuclease activity.
Emily C Sheppard, Sally Rogers, Nicholas J Harmer, Richard Chahwan.
Sci Rep, 2019 Jun 22; 9(1). PMID: 31222049    Free PMC article.
Enhancer reprogramming in tumor progression: a new route towards cancer cell plasticity.
Luca Fagnocchi, Vittoria Poli, Alessio Zippo.
Cell Mol Life Sci, 2018 Apr 25; 75(14). PMID: 29691590
Review.
Stochastic Endogenous Replication Stress Causes ATR-Triggered Fluctuations in CDK2 Activity that Dynamically Adjust Global DNA Synthesis Rates.
Leighton H Daigh, Chad Liu, +2 authors, Tobias Meyer.
Cell Syst, 2018 Jun 18; 7(1). PMID: 29909278    Free PMC article.
The roles of RNA in DNA double-strand break repair.
Aldo S Bader, Ben R Hawley, Ania Wilczynska, Martin Bushell.
Br J Cancer, 2020 Jan 03; 122(5). PMID: 31894141    Free PMC article.
Review.
DNA Sequencing of Small Bowel Adenocarcinomas Identifies Targetable Recurrent Mutations in the ERBB2 Signaling Pathway.
Liana Adam, F Anthony San Lucas, +13 authors, Michael J Overman.
Clin Cancer Res, 2018 Oct 26; 25(2). PMID: 30352910    Free PMC article.
ITCH nuclear translocation and H1.2 polyubiquitination negatively regulate the DNA damage response.
Lufen Chang, Lei Shen, +9 authors, Binghui Shen.
Nucleic Acids Res, 2018 Dec 06; 47(2). PMID: 30517763    Free PMC article.
The frequencies of micronuclei, nucleoplasmic bridges and nuclear buds as biomarkers of genomic instability in patients with urothelial cell carcinoma.
Arjeta Podrimaj-Bytyqi, Ana Borovečki, +3 authors, Isa R Elezaj.
Sci Rep, 2018 Dec 16; 8(1). PMID: 30552338    Free PMC article.
Bacteria-to-Human Protein Networks Reveal Origins of Endogenous DNA Damage.
Jun Xia, Li-Ya Chiu, +31 authors, Susan M Rosenberg.
Cell, 2019 Jan 12; 176(1-2). PMID: 30633903    Free PMC article.
Highly Cited.
Nucleostemin reveals a dichotomous nature of genome maintenance in mammary tumor progression.
Tao Lin, Tsung-Chin Lin, +7 authors, Robert Y L Tsai.
Oncogene, 2019 Jan 30; 38(20). PMID: 30692636    Free PMC article.
Mitochondrial fusion supports increased oxidative phosphorylation during cell proliferation.
Cong-Hui Yao, Rencheng Wang, +3 authors, Gary J Patti.
Elife, 2019 Jan 30; 8. PMID: 30694178    Free PMC article.
Highly Cited.
From genome integrity to cancer.
Serena Nik-Zainal.
Genome Med, 2019 Jan 31; 11(1). PMID: 30696459    Free PMC article.
The Molecular Chaperone Heat Shock Protein 70 Controls Liver Cancer Initiation and Progression by Regulating Adaptive DNA Damage and Mitogen-Activated Protein Kinase/Extracellular Signal-Regulated Kinase Signaling Pathways.
Wonkyoung Cho, Xiongjie Jin, +3 authors, Demetrius Moskophidis.
Mol Cell Biol, 2019 Feb 13; 39(9). PMID: 30745413    Free PMC article.
Base excision repair regulates PD-L1 expression in cancer cells.
Tiara Bunga Mayang Permata, Yoshihiko Hagiwara, +6 authors, Atsushi Shibata.
Oncogene, 2019 Feb 14; 38(23). PMID: 30755733
IDH1-R132H acts as a tumor suppressor in glioma via epigenetic up-regulation of the DNA damage response.
Felipe J Núñez, Flor M Mendez, +32 authors, Maria G Castro.
Sci Transl Med, 2019 Feb 15; 11(479). PMID: 30760578    Free PMC article.
Highly Cited.
A meiosis-specific BRCA2 binding protein recruits recombinases to DNA double-strand breaks to ensure homologous recombination.
Jingjing Zhang, Yasuhiro Fujiwara, Shohei Yamamoto, Hiroki Shibuya.
Nat Commun, 2019 Feb 15; 10(1). PMID: 30760716    Free PMC article.
Determination of the activity of uracil-DNA glycosylase by using two-tailed reverse transcription PCR and gold nanoparticle-mediated silver nanocluster fluorescence: a new method for gene therapy-related enzyme detection.
Kai Zhang, Wanting Huang, +3 authors, Minhao Xie.
Mikrochim Acta, 2019 Feb 17; 186(3). PMID: 30771014
A new perspective on oxidation of DNA repair proteins and cancer.
Khadijeh S Alnajjar, Joann B Sweasy.
DNA Repair (Amst), 2019 Mar 01; 76. PMID: 30818170    Free PMC article.
Review.
Genomic stratification and liquid biopsy in a rare adrenocortical carcinoma (ACC) case, with dual lung metastases.
Mark J McCabe, Mark Pinese, +19 authors, Mark J Cowley.
Cold Spring Harb Mol Case Stud, 2019 Apr 03; 5(2). PMID: 30936196    Free PMC article.
p62-mediated Selective autophagy endows virus-transformed cells with insusceptibility to DNA damage under oxidative stress.
Ling Wang, Mary E A Howell, +7 authors, Shunbin Ning.
PLoS Pathog, 2019 Apr 25; 15(4). PMID: 31017975    Free PMC article.
Ca2+-Stimulated AMPK-Dependent Phosphorylation of Exo1 Protects Stressed Replication Forks from Aberrant Resection.
Shan Li, Zeno Lavagnino, +10 authors, Zhongsheng You.
Mol Cell, 2019 May 06; 74(6). PMID: 31053472    Free PMC article.
SSB1/SSB2 Proteins Safeguard B Cell Development by Protecting the Genomes of B Cell Precursors.
Matthias Pfeifer, Reto Brem, +5 authors, Niklas Feldhahn.
J Immunol, 2019 May 16; 202(12). PMID: 31085591    Free PMC article.
Methods for Studying DNA Single-Strand Break Repair and Signaling in Xenopus laevis Egg Extracts.
Yunfeng Lin, Anh Ha, Shan Yan.
Methods Mol Biol, 2019 May 28; 1999. PMID: 31127575    Free PMC article.
Preserving genome integrity and function: the DNA damage response and histone modifications.
Jae Jin Kim, Seo Yun Lee, Kyle M Miller.
Crit Rev Biochem Mol Biol, 2019 Jun 06; 54(3). PMID: 31164001    Free PMC article.
Review.
ABCB1 protects bat cells from DNA damage induced by genotoxic compounds.
Javier Koh, Yoko Itahana, +6 authors, Koji Itahana.
Nat Commun, 2019 Jun 30; 10(1). PMID: 31249297    Free PMC article.
Chk1 loss creates replication barriers that compromise cell survival independently of excess origin firing.
Marina A González Besteiro, Nicolás L Calzetta, +7 authors, Vanesa Gottifredi.
EMBO J, 2019 Jul 12; 38(16). PMID: 31294866    Free PMC article.
SPRTN protease and checkpoint kinase 1 cross-activation loop safeguards DNA replication.
Swagata Halder, Ignacio Torrecilla, +12 authors, Kristijan Ramadan.
Nat Commun, 2019 Jul 19; 10(1). PMID: 31316063    Free PMC article.
CtIP is essential for telomere replication.
Susanna Stroik, Kevin Kurtz, Eric A Hendrickson.
Nucleic Acids Res, 2019 Aug 06; 47(17). PMID: 31378812    Free PMC article.
A cohesin/HUSH- and LINC-dependent pathway controls ribosomal DNA double-strand break repair.
Aline Marnef, Anne-Laure Finoux, +7 authors, Gaëlle Legube.
Genes Dev, 2019 Aug 10; 33(17-18). PMID: 31395742    Free PMC article.
Oncogenic Roles of GOLPH3 in the Physiopathology of Cancer.
Stefano Sechi, Anna Frappaolo, +2 authors, Maria Grazia Giansanti.
Int J Mol Sci, 2020 Feb 07; 21(3). PMID: 32023813    Free PMC article.
Review.
A Novel Long Non-coding RNA, MSTRG.51053.2 Regulates Cisplatin Resistance by Sponging the miR-432-5p in Non-small Cell Lung Cancer Cells.
Jie Zhang, Chuanqin Xu, +6 authors, Yufeng Wan.
Front Oncol, 2020 Mar 12; 10. PMID: 32158694    Free PMC article.
Association between DNA damage repair gene somatic mutations and immune-related gene expression in ovarian cancer.
Wenjuan Tian, Boer Shan, +11 authors, Huaying Wang.
Cancer Med, 2020 Jan 29; 9(6). PMID: 31991061    Free PMC article.
PARP and PARG inhibitors in cancer treatment.
Dea Slade.
Genes Dev, 2020 Feb 08; 34(5-6). PMID: 32029455    Free PMC article.
Review.
TEX264 coordinates p97- and SPRTN-mediated resolution of topoisomerase 1-DNA adducts.
John Fielden, Katherine Wiseman, +14 authors, Kristijan Ramadan.
Nat Commun, 2020 Mar 11; 11(1). PMID: 32152270    Free PMC article.
RAD52: Viral Friend or Foe?
Eric A Hendrickson.
Cancers (Basel), 2020 Feb 13; 12(2). PMID: 32046320    Free PMC article.
Review.
Nuclear myosin 1 activates p21 gene transcription in response to DNA damage through a chromatin-based mechanism.
Tomas Venit, Khairunnisa Semesta, +4 authors, Piergiorgio Percipalle.
Commun Biol, 2020 Mar 13; 3(1). PMID: 32161327    Free PMC article.
Fanconi anemia pathway as a prospective target for cancer intervention.
Wenjun Liu, Anna Palovcak, +3 authors, Yanbin Zhang.
Cell Biosci, 2020 Mar 20; 10. PMID: 32190289    Free PMC article.
Review.
Prospects for combining immune checkpoint blockade with PARP inhibition.
Anping Li, Ming Yi, +3 authors, Kongming Wu.
J Hematol Oncol, 2019 Sep 16; 12(1). PMID: 31521196    Free PMC article.
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Molecular flexibility of DNA as a key determinant of RAD51 recruitment.
Federico Paoletti, Afaf H El-Sagheer, +3 authors, Fumiko Esashi.
EMBO J, 2020 Jan 17; 39(7). PMID: 31943278    Free PMC article.
Comprehensive analysis of indels in whole-genome microsatellite regions and microsatellite instability across 21 cancer types.
Akihiro Fujimoto, Masashi Fujita, +10 authors, Hidewaki Nakagawa.
Genome Res, 2020 Mar 27;. PMID: 32209592    Free PMC article.
Phosphatase 1 Nuclear Targeting Subunit Mediates Recruitment and Function of Poly (ADP-Ribose) Polymerase 1 in DNA Repair.
Feifei Wang, Songli Zhu, +5 authors, Aimin Peng.
Cancer Res, 2019 Feb 09; 79(10). PMID: 30733193    Free PMC article.
Pan-cancer analysis reveals synergistic effects of CDK4/6i and PARPi combination treatment in RB-proficient and RB-deficient breast cancer cells.
Songyu Li, Yixiang Zhang, +6 authors, Qing-Kai Yang.
Cell Death Dis, 2020 Apr 07; 11(4). PMID: 32249776    Free PMC article.
Molecular-Clinical Correlation in Pediatric Medulloblastoma: A Cohort Series Study of 52 Cases in Taiwan.
Kuo-Sheng Wu, Donald Ming-Tak Ho, +24 authors, Tai-Tong Wong.
Cancers (Basel), 2020 Mar 15; 12(3). PMID: 32168907    Free PMC article.
Norepinephrine-Induced DNA Damage in Ovarian Cancer Cells.
Rocio Lamboy-Caraballo, Carmen Ortiz-Sanchez, +3 authors, Guillermo N Armaiz-Pena.
Int J Mol Sci, 2020 Mar 28; 21(6). PMID: 32213975    Free PMC article.
Job Opening for Nucleosome Mechanic: Flexibility Required.
Mary Pitman, Daniël P Melters, Yamini Dalal.
Cells, 2020 Mar 04; 9(3). PMID: 32121488    Free PMC article.
Review.
Screening common signaling pathways associated with drug resistance in non-small cell lung cancer via gene expression profile analysis.
Ting Sun, Qitai Zhao, +9 authors, Yi Zhang.
Cancer Med, 2019 Apr 27; 8(6). PMID: 31025554    Free PMC article.
Mycobacterium tuberculosis exploits host ATM kinase for survival advantage through SecA2 secretome.
Savita Lochab, Yogendra Singh, Sagar Sengupta, Vinay Kumar Nandicoori.
Elife, 2020 Apr 01; 9. PMID: 32223892    Free PMC article.
Physicochemical Foundations of Life that Direct Evolution: Chance and Natural Selection are not Evolutionary Driving Forces.
Didier Auboeuf.
Life (Basel), 2020 Jan 25; 10(2). PMID: 31973071    Free PMC article.
Methylation of the Suppressor Gene p16INK4a: Mechanism and Consequences.
Alfonso Tramontano, Francesca Ludovica Boffo, +3 authors, Antonio Pezone.
Biomolecules, 2020 Mar 19; 10(3). PMID: 32183138    Free PMC article.
FOXL2 directs DNA double-strand break repair pathways by differentially interacting with Ku.
Hanyong Jin, Boeun Lee, +10 authors, Jeehyeon Bae.
Nat Commun, 2020 Apr 26; 11(1). PMID: 32332759    Free PMC article.
A Preliminary Study: Human Fibroid Stro-1+/CD44+ Stem Cells Isolated From Uterine Fibroids Demonstrate Decreased DNA Repair and Genomic Integrity Compared to Adjacent Myometrial Stro-1+/CD44+ Cells.
Lauren E Prusinski Fernung, Ayman Al-Hendy, Qiwei Yang.
Reprod Sci, 2018 Jun 30; 26(5). PMID: 29954254    Free PMC article.
The antitumorigenic roles of BRCA1-BARD1 in DNA repair and replication.
Madalena Tarsounas, Patrick Sung.
Nat Rev Mol Cell Biol, 2020 Feb 26; 21(5). PMID: 32094664    Free PMC article.
Review.
Cooperation and interplay between base and nucleotide excision repair pathways: From DNA lesions to proteins.
Namrata Kumar, Natália C Moreno, +2 authors, Bennett Van Houten.
Genet Mol Biol, 2020 Mar 07; 43(1 suppl. 1). PMID: 32141475    Free PMC article.
DNA lesions and repair in trypanosomatids infection.
Bruno M Repolês, Carlos Renato Machado, Pilar T V Florentino.
Genet Mol Biol, 2020 Apr 03; 43(1 suppl. 1). PMID: 32236391    Free PMC article.
Mapping the breakome reveals tight regulation on oncogenic super-enhancers.
Sara Oster, Rami I Aqeilan.
Mol Cell Oncol, 2020 May 12; 7(3). PMID: 32391416    Free PMC article.
Modeling clinical and molecular covariates of mutational process activity in cancer.
Welles Robinson, Roded Sharan, Mark D M Leiserson.
Bioinformatics, 2019 Sep 13; 35(14). PMID: 31510643    Free PMC article.
A highly accurate platform for clone-specific mutation discovery enables the study of active mutational processes.
Mohammad KaramiNejadRanjbar, Sahand Sharifzadeh, +6 authors, Ahmed A Ahmed.
Elife, 2020 Apr 08; 9. PMID: 32255426    Free PMC article.
MiRNAs Targeting Double Strand DNA Repair Pathways Lurk in Genomically Unstable Rare Fragile Sites and Determine Cancer Outcomes.
Stephan Marquardt, Christin Richter, Brigitte M Pützer, Stella Logotheti.
Cancers (Basel), 2020 Apr 09; 12(4). PMID: 32260317    Free PMC article.
The BRUCE-ATR Signaling Axis Is Required for Accurate DNA Replication and Suppression of Liver Cancer Development.
Chunmin Ge, Chrystelle L Vilfranc, +11 authors, Chunying Du.
Hepatology, 2019 Jan 30; 69(6). PMID: 30693543    Free PMC article.
HDAC1 modulates OGG1-initiated oxidative DNA damage repair in the aging brain and Alzheimer's disease.
Ping-Chieh Pao, Debasis Patnaik, +15 authors, Li-Huei Tsai.
Nat Commun, 2020 May 20; 11(1). PMID: 32424276    Free PMC article.
Suppressing PARylation by 2',5'-oligoadenylate synthetase 1 inhibits DNA damage-induced cell death.
Anna A Kondratova, HyeonJoo Cheon, +7 authors, George R Stark.
EMBO J, 2020 Apr 24; 39(11). PMID: 32323871    Free PMC article.
Quantitative Estimation of Oxidative Stress in Cancer Tissue Cells Through Gene Expression Data Analyses.
Liyang Liu, Haining Cui, Ying Xu.
Front Genet, 2020 Jun 13; 11. PMID: 32528526    Free PMC article.
NORAD orchestrates endometrial cancer progression by sequestering FUBP1 nuclear localization to promote cell apoptosis.
Tong Han, Yukang Wu, +8 authors, Xiaoping Wan.
Cell Death Dis, 2020 Jun 20; 11(6). PMID: 32555178    Free PMC article.
DNA double-strand breaks induce H2Ax phosphorylation domains in a contact-dependent manner.
Patrick L Collins, Caitlin Purman, +8 authors, Eugene M Oltz.
Nat Commun, 2020 Jun 24; 11(1). PMID: 32572033    Free PMC article.
TRIP13 regulates DNA repair pathway choice through REV7 conformational change.
Connor S Clairmont, Prabha Sarangi, +7 authors, Alan D D'Andrea.
Nat Cell Biol, 2020 Jan 10; 22(1). PMID: 31915374    Free PMC article.
Overcoming cancer therapeutic bottleneck by drug repurposing.
Zhe Zhang, Li Zhou, +4 authors, Canhua Huang.
Signal Transduct Target Ther, 2020 Jul 04; 5(1). PMID: 32616710    Free PMC article.
Review.
Integrated bioinformatics analysis of expression and gene regulation network of COL12A1 in colorectal cancer.
Yibin Wu, Ye Xu.
Cancer Med, 2020 May 02; 9(13). PMID: 32356618    Free PMC article.
Interaction between RECQL4 and OGG1 promotes repair of oxidative base lesion 8-oxoG and is regulated by SIRT1 deacetylase.
Shunlei Duan, Xuerui Han, +3 authors, Vilhelm A Bohr.
Nucleic Acids Res, 2020 May 21; 48(12). PMID: 32432680    Free PMC article.
Topoisomerase II contributes to DNA secondary structure-mediated double-stranded breaks.
Karol Szlachta, Arkadi Manukyan, +5 authors, Yuh-Hwa Wang.
Nucleic Acids Res, 2020 Jun 06; 48(12). PMID: 32501506    Free PMC article.
Pathological mutations in PNKP trigger defects in DNA single-strand break repair but not DNA double-strand break repair.
Ilona Kalasova, Richard Hailstone, +5 authors, Keith W Caldecott.
Nucleic Acids Res, 2020 Jun 07; 48(12). PMID: 32504494    Free PMC article.
Genomic instability and cancer: lessons from Drosophila.
Stephan U Gerlach, Héctor Herranz.
Open Biol, 2020 Jun 03; 10(6). PMID: 32485126    Free PMC article.
Review.
Breast Cancer Chemotherapeutic Options: A General Overview on the Preclinical Validation of a Multi-Target Ruthenium(III) Complex Lodged in Nucleolipid Nanosystems.
Maria Grazia Ferraro, Marialuisa Piccolo, +6 authors, Carlo Irace.
Cells, 2020 Jun 11; 9(6). PMID: 32517101    Free PMC article.
Review.
Combined PARP Inhibition and Immune Checkpoint Therapy in Solid Tumors.
Florent Peyraud, Antoine Italiano.
Cancers (Basel), 2020 Jun 13; 12(6). PMID: 32526888    Free PMC article.
Review.
Role of Anillin in Tumour: From a Prognostic Biomarker to a Novel Target.
Nguyen Minh Tuan, Chang Hoon Lee.
Cancers (Basel), 2020 Jun 21; 12(6). PMID: 32560530    Free PMC article.
Review.
RECQ1 Helicase in Genomic Stability and Cancer.
Subrata Debnath, Sudha Sharma.
Genes (Basel), 2020 Jun 11; 11(6). PMID: 32517021    Free PMC article.
Review.
Increased MTH1-specific 8-oxodGTPase activity is a hallmark of cancer in colon, lung and pancreatic tissue.
Lisa A McPherson, Clara I Troccoli, +10 authors, James M Ford.
DNA Repair (Amst), 2019 Jul 18; 83. PMID: 31311767    Free PMC article.
The Impact of Dietary Supplementation of Whole Foods and Polyphenols on Atherosclerosis.
Abigail E Cullen, Ann Marie Centner, Riley Deitado, Javier Fernandez andGloria Salazar.
Nutrients, 2020 Jul 16; 12(7). PMID: 32664664    Free PMC article.
Review.
DNA Damage: From Threat to Treatment.
Antonio Carusillo, Claudio Mussolino.
Cells, 2020 Jul 16; 9(7). PMID: 32664329    Free PMC article.
Review.
Mutational signature SBS8 predominantly arises due to late replication errors in cancer.
Vinod Kumar Singh, Arnav Rastogi, +2 authors, Subhajyoti De.
Commun Biol, 2020 Aug 05; 3(1). PMID: 32747711    Free PMC article.
APOBEC3B expression in breast cancer cell lines and tumors depends on the estrogen receptor status.
Krizia-Ivana Udquim, Clara Zettelmeyer, +2 authors, Ludmila Prokunina-Olsson.
Carcinogenesis, 2020 Jan 14; 41(8). PMID: 31930332    Free PMC article.
The Importance of ATM and ATR in Physcomitrella patens DNA Damage Repair, Development, and Gene Targeting.
Martin Martens, Ralf Horres, Edelgard Wendeler, Bernd Reiss.
Genes (Basel), 2020 Jul 10; 11(7). PMID: 32640722    Free PMC article.
NME3 Regulates Mitochondria to Reduce ROS-Mediated Genome Instability.
Chih-Wei Chen, Ning Tsao, Wei Zhang, Zee-Fen Chang.
Int J Mol Sci, 2020 Jul 28; 21(14). PMID: 32708927    Free PMC article.
The Therapeutic Potential of DNA Damage Repair Pathways and Genomic Stability in Lung Cancer.
Joshua T Burgess, Maddison Rose, +7 authors, Emma Bolderson.
Front Oncol, 2020 Aug 28; 10. PMID: 32850380    Free PMC article.
Review.
BRD4 prevents the accumulation of R-loops and protects against transcription-replication collision events and DNA damage.
Fred C Lam, Yi Wen Kong, +4 authors, Michael B Yaffe.
Nat Commun, 2020 Aug 17; 11(1). PMID: 32796829    Free PMC article.
The Chromatin Response to Double-Strand DNA Breaks and Their Repair.
Radoslav Aleksandrov, Rossitsa Hristova, Stoyno Stoynov, Anastas Gospodinov.
Cells, 2020 Aug 14; 9(8). PMID: 32784607    Free PMC article.
Review.
Inhibition of non-homologous end joining of gamma ray-induced DNA double-strand breaks by cAMP signaling in lung cancer cells.
Sung-Eun Noh, Yong-Sung Juhnn.
Sci Rep, 2020 Sep 04; 10(1). PMID: 32879366    Free PMC article.
The human microbiome and its link in prostate cancer risk and pathogenesis.
Paul Katongole, Obondo J Sande, +2 authors, Nixon Niyonzima.
Infect Agent Cancer, 2020 Sep 05; 15. PMID: 32884579    Free PMC article.
Review.
Contribution of MUTYH Variants to Male Breast Cancer Risk: Results From a Multicenter Study in Italy.
Piera Rizzolo, Valentina Silvestri, +23 authors, Laura Ottini.
Front Oncol, 2018 Dec 20; 8. PMID: 30564557    Free PMC article.
Effective Distance for DNA-Mediated Charge Transport between Repair Proteins.
Edmund C M Tse, Theodore J Zwang, Sebastian Bedoya, Jacqueline K Barton.
ACS Cent Sci, 2019 Jan 30; 5(1). PMID: 30693326    Free PMC article.
Targeting androgen receptor-independent pathways in therapy-resistant prostate cancer.
Lingfan Xu, Junyi Chen, +3 authors, Jiaoti Huang.
Asian J Urol, 2019 Feb 19; 6(1). PMID: 30775252    Free PMC article.
Review.
Origin of mutations in genes associated with human glioblastoma multiform cancer: random polymerase errors versus deamination.
Min Zhang, Da Yang, Barry Gold.
Heliyon, 2019 Mar 23; 5(3). PMID: 30899826    Free PMC article.
The antioxidant components of milk and their role in processing, ripening, and storage: Functional food.
Imran Taj Khan, Mohammed Bule, +3 authors, Kamal Niaz.
Vet World, 2019 Apr 03; 12(1). PMID: 30936650    Free PMC article.
Entanglement of Genetics and Epigenetics in Parkinson's Disease.
H J van Heesbeen, Marten P Smidt.
Front Neurosci, 2019 Apr 16; 13. PMID: 30983962    Free PMC article.
Review.
Location analysis of 8-oxo-7,8-dihydroguanine in DNA by polymerase-mediated differential coding.
Feng Tang, Shan Liu, +5 authors, Yu-Qi Feng.
Chem Sci, 2019 Apr 25; 10(15). PMID: 31015952    Free PMC article.
From Powerhouse to Perpetrator-Mitochondria in Health and Disease.
Nima B Fakouri, Thomas Lau Hansen, +2 authors, Lene Juel Rasmussen.
Biology (Basel), 2019 May 15; 8(2). PMID: 31083572    Free PMC article.
Review.
DNA Repair Deficiency in Breast Cancer: Opportunities for Immunotherapy.
Elaine Gilmore, Nuala McCabe, Richard D Kennedy, Eileen E Parkes.
J Oncol, 2019 Jul 20; 2019. PMID: 31320901    Free PMC article.
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Potential Mechanisms of Age Acceleration Caused by Estrogen Deprivation: Do Endocrine Therapies Carry the Same Risks?
Mary E Sehl, Patricia A Ganz.
JNCI Cancer Spectr, 2019 Jul 31; 2(3). PMID: 31360862    Free PMC article.
Review.
Immunosurveillance of cancer cell stress.
Seila Lorenzo-Herrero, Christian Sordo-Bahamonde, Segundo González, Alejandro López-Soto.
Cell Stress, 2019 Sep 20; 3(9). PMID: 31535086    Free PMC article.
Review.
Misrepair in Context: TGFβ Regulation of DNA Repair.
Qi Liu, Kirsten Lopez, +2 authors, Mary Helen Barcellos-Hoff.
Front Oncol, 2019 Sep 26; 9. PMID: 31552165    Free PMC article.
Review.
The Electronic Property Differences between dA::dG and dA::dGoxo. A Theoretical Approach.
Boleslaw T Karwowski.
Molecules, 2020 Aug 28; 25(17). PMID: 32842464    Free PMC article.
Recent advances in the nucleolar responses to DNA double-strand breaks.
Lea Milling Korsholm, Zita Gál, +4 authors, Dorthe Helena Larsen.
Nucleic Acids Res, 2020 Aug 29; 48(17). PMID: 32857853    Free PMC article.
Review.
Matrix metalloproteinase 9 (MMP9) limits reactive oxygen species (ROS) accumulation and DNA damage in colitis-associated cancer.
Lewins Walter, Brandon Canup, +5 authors, Pallavi Garg.
Cell Death Dis, 2020 Sep 19; 11(9). PMID: 32943603    Free PMC article.
Inhibition of autophagy aggravates DNA damage response and gastric tumorigenesis via Rad51 ubiquitination in response to H. pylori infection.
Chuan Xie, Nianshuang Li, +10 authors, Nonghua Lu.
Gut Microbes, 2020 Jun 27; 11(6). PMID: 32588736    Free PMC article.
Relapse-related molecular signature in early-stage lung adenocarcinomas based on base excision repair, stimulator of interferon genes pathway and tumor-infiltrating lymphocytes.
Bo Yang, Wen Rao, +2 authors, Dong Wang.
Cancer Sci, 2020 Jul 13; 111(10). PMID: 32654272    Free PMC article.
Non-Coding RNAs as Cancer Hallmarks in Chronic Lymphocytic Leukemia.
Linda Fabris, Jaroslav Juracek, George Calin.
Int J Mol Sci, 2020 Sep 18; 21(18). PMID: 32937758    Free PMC article.
Review.
Origin of Genome Instability and Determinants of Mutational Landscape in Cancer Cells.
Sonam Mehrotra, Indraneel Mittra.
Genes (Basel), 2020 Sep 25; 11(9). PMID: 32967144    Free PMC article.
Review.
Fused in Sarcoma (FUS) in DNA Repair: Tango with Poly(ADP-ribose) Polymerase 1 and Compartmentalisation of Damaged DNA.
Maria V Sukhanova, Anastasia S Singatulina, David Pastré, Olga I Lavrik.
Int J Mol Sci, 2020 Sep 30; 21(19). PMID: 32987654    Free PMC article.
Review.
Integrating pathology, chromosomal instability and mutations for risk stratification in early-stage endometrioid endometrial carcinoma.
Yuan Li, Jiaqi Li, +20 authors, Gang Chen.
Cell Biosci, 2020 Oct 29; 10. PMID: 33110489    Free PMC article.
Copper Complexes as Anticancer Agents Targeting Topoisomerases I and II.
Caroline Molinaro, Alain Martoriati, Lydie Pelinski, Katia Cailliau.
Cancers (Basel), 2020 Oct 09; 12(10). PMID: 33027952    Free PMC article.
Review.
Making it or breaking it: DNA methylation and genome integrity.
Anusha Sriraman, Turja K Debnath, Blerta Xhemalce, Kyle M Miller.
Essays Biochem, 2020 Aug 19; 64(5). PMID: 32808652    Free PMC article.
Review.
Sustained androgen receptor signaling is a determinant of melanoma cell growth potential and tumorigenesis.
Min Ma, Soumitra Ghosh, +12 authors, G Paolo Dotto.
J Exp Med, 2020 Oct 29; 218(2). PMID: 33112375    Free PMC article.
Label-Free Proteomics Reveals the Molecular Mechanism of Subculture Induced Strain Degeneration and Discovery of Indicative Index for Degeneration in Pleurotus ostreatus.
Weiwei Zhu, Jinbo Hu, +7 authors, Yongming Bao.
Molecules, 2020 Oct 30; 25(21). PMID: 33114310    Free PMC article.
A Comprehensive Analysis of Alterations in DNA Damage Repair Pathways Reveals a Potential Way to Enhance the Radio-Sensitivity of Esophageal Squamous Cell Cancer.
Guangchao Wang, Shichao Guo, +5 authors, Qimin Zhan.
Front Oncol, 2020 Nov 13; 10. PMID: 33178606    Free PMC article.
Editorial: Exploiting DNA Damage Response in the Era of Precision Oncology.
Yitzhak Zimmer, Hans Christian Reinhardt, Michaela Medová.
Front Oncol, 2020 Nov 13; 10. PMID: 33178619    Free PMC article.
Ewing sarcoma protein promotes dissociation of poly(ADP-ribose) polymerase 1 from chromatin.
Seon-Gyeong Lee, Namwoo Kim, +9 authors, Kyungjae Myung.
EMBO Rep, 2020 Oct 03; 21(11). PMID: 33006225    Free PMC article.
In Vivo Imaging with Genetically Encoded Redox Biosensors.
Alexander I Kostyuk, Anastasiya S Panova, +5 authors, Dmitry S Bilan.
Int J Mol Sci, 2020 Nov 05; 21(21). PMID: 33142884    Free PMC article.
Review.
Targeting DNA Damage Response in Prostate and Breast Cancer.
Antje M Wengner, Arne Scholz, Bernard Haendler.
Int J Mol Sci, 2020 Nov 08; 21(21). PMID: 33158305    Free PMC article.
Review.
Transcriptional Characteristics of IDH-Wild Type Glioma Subgroups Highlight the Biological Processes Underlying Heterogeneity of IDH-Wild Type WHO Grade IV Gliomas.
Yu-Zhou Chang, Guan-Zhang Li, +5 authors, Rui-Chao Chai.
Front Cell Dev Biol, 2020 Nov 17; 8. PMID: 33195221    Free PMC article.
Yeast Rpn4 Links the Proteasome and DNA Repair via RAD52 Regulation.
Daria S Spasskaya, Nonna I Nadolinskaia, +3 authors, Dmitry S Karpov.
Int J Mol Sci, 2020 Nov 05; 21(21). PMID: 33143019    Free PMC article.
The involvement of nucleotide excision repair proteins in the removal of oxidative DNA damage.
Namrata Kumar, Sripriya Raja, Bennett Van Houten.
Nucleic Acids Res, 2020 Oct 04; 48(20). PMID: 33010169    Free PMC article.
Review.
From "Cellular" RNA to "Smart" RNA: Multiple Roles of RNA in Genome Stability and Beyond.
Flavia Michelini, Ameya P Jalihal, +13 authors, Fabrizio d'Adda di Fagagna.
Chem Rev, 2018 Mar 31; 118(8). PMID: 29600857    Free PMC article.
Review.
Mechanism for Synthetic Lethality in BRCA-Deficient Cancers: No Longer Lagging Behind.
Niek van Wietmarschen, Andre Nussenzweig.
Mol Cell, 2018 Sep 23; 71(6). PMID: 30241603    Free PMC article.
The Emerging Role of Cohesin in the DNA Damage Response.
Ireneusz Litwin, Ewa Pilarczyk, Robert Wysocki.
Genes (Basel), 2018 Nov 30; 9(12). PMID: 30487431    Free PMC article.
Review.
Endogenous DNA Double-Strand Breaks during DNA Transactions: Emerging Insights and Methods for Genome-Wide Profiling.
Britta A M Bouwman, Nicola Crosetto.
Genes (Basel), 2018 Dec 19; 9(12). PMID: 30558210    Free PMC article.
Review.
Regulation of Structure-Specific Endonucleases in Replication Stress.
Seong Min Kim, Susan L Forsburg.
Genes (Basel), 2018 Dec 19; 9(12). PMID: 30558228    Free PMC article.
Review.
Linking the organization of DNA replication with genome maintenance.
Balveer Singh, Pei-Yun Jenny Wu.
Curr Genet, 2019 Jan 03; 65(3). PMID: 30600398
Review.
Stress Marks on the Genome: Use or Lose?
Bayan Bokhari, Sudha Sharma.
Int J Mol Sci, 2019 Jan 19; 20(2). PMID: 30654540    Free PMC article.
Review.
Helicobacter pylori infection and gastric cancer biology: tempering a double-edged sword.
Alexios-Fotios A Mentis, Marina Boziki, Nikolaos Grigoriadis, Athanasios G Papavassiliou.
Cell Mol Life Sci, 2019 Feb 21; 76(13). PMID: 30783683
Computational analysis of data from a genome-wide screening identifies new PARP1 functional interactors as potential therapeutic targets.
Samuele Lodovichi, Alberto Mercatanti, Tiziana Cervelli, Alvaro Galli.
Oncotarget, 2019 May 21; 10(28). PMID: 31105872    Free PMC article.
Smooth Muscle Phenotype in Idiopathic Pulmonary Hypertension: Hyper-Proliferative but not Cancerous.
Frédéric Perros, Pierre Sentenac, +9 authors, Saadia Eddahibi.
Int J Mol Sci, 2019 Jul 25; 20(14). PMID: 31336611    Free PMC article.
Genetic and epigenetic determinants of diffuse large B-cell lymphoma.
Tanner J Bakhshi, Philippe T Georgel.
Blood Cancer J, 2020 Dec 06; 10(12). PMID: 33277464    Free PMC article.
Review.
Focus on DNA Glycosylases-A Set of Tightly Regulated Enzymes with a High Potential as Anticancer Drug Targets.
Fabienne Hans, Muge Senarisoy, Chandini Bhaskar Naidu, Joanna Timmins.
Int J Mol Sci, 2020 Dec 09; 21(23). PMID: 33287345    Free PMC article.
Review.
Evolving insights: how DNA repair pathways impact cancer evolution.
Jiadong Zhou, Xiao Albert Zhou, Ning Zhang, Jiadong Wang.
Cancer Biol Med, 2020 Dec 11; 17(4). PMID: 33299637    Free PMC article.
Review.
Long non-coding RNA: A recently accentuated molecule in chemoresistance in cancer.
Yang Peng, Dihong Tang, +3 authors, Yutaka Kondo.
Cancer Metastasis Rev, 2020 Jul 01; 39(3). PMID: 32594276
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A unified model for the G1/S cell cycle transition.
Samuel Hume, Grigory L Dianov, Kristijan Ramadan.
Nucleic Acids Res, 2020 Nov 10; 48(22). PMID: 33166394    Free PMC article.
Review.
Aberrant Activity of Histone-Lysine N-Methyltransferase 2 (KMT2) Complexes in Oncogenesis.
Elzbieta Poreba, Krzysztof Lesniewicz, Julia Durzynska.
Int J Mol Sci, 2020 Dec 12; 21(24). PMID: 33302406    Free PMC article.
Review.
DNA Damage Response in Prostate Cancer.
Matthew J Schiewer, Karen E Knudsen.
Cold Spring Harb Perspect Med, 2018 Mar 14; 9(1). PMID: 29530944    Free PMC article.
Review.
Impact of 2 Gy γ-irradiation on the hallmark characteristics of human bone marrow-derived MSCs.
Masaki Iwasa, Sumie Fujii, +5 authors, Yasuo Miura.
Int J Hematol, 2021 Jan 03; 113(5). PMID: 33386593
Dual Roles of Poly(dA:dT) Tracts in Replication Initiation and Fork Collapse.
Anthony Tubbs, Sriram Sridharan, +17 authors, André Nussenzweig.
Cell, 2018 Aug 07; 174(5). PMID: 30078706    Free PMC article.
Highly Cited.
Asbestos conceives Fe(II)-dependent mutagenic stromal milieu through ceaseless macrophage ferroptosis and β-catenin induction in mesothelium.
Fumiya Ito, Izumi Yanatori, +8 authors, Shinya Toyokuni.
Redox Biol, 2020 Aug 31; 36. PMID: 32863225    Free PMC article.
Haloferax volcanii-a model archaeon for studying DNA replication and repair.
Patricia Pérez-Arnaiz, Ambika Dattani, Victoria Smith, Thorsten Allers.
Open Biol, 2020 Dec 02; 10(12). PMID: 33259746    Free PMC article.
Ancient Sturgeons Possess Effective DNA Repair Mechanisms: Influence of Model Genotoxicants on Embryo Development of Sterlet, Acipenser ruthenus.
Ievgeniia Gazo, Roman Franěk, +4 authors, Christoph Steinbach.
Int J Mol Sci, 2020 Dec 31; 22(1). PMID: 33374934    Free PMC article.
DNA damage and mitochondria in cancer and aging.
Jaimin Patel, Beverly A Baptiste, +3 authors, Vilhelm A Bohr.
Carcinogenesis, 2020 Nov 05; 41(12). PMID: 33146705    Free PMC article.
Review.
Heritable pattern of oxidized DNA base repair coincides with pre-targeting of repair complexes to open chromatin.
Albino Bacolla, Shiladitya Sengupta, +9 authors, John A Tainer.
Nucleic Acids Res, 2020 Dec 11; 49(1). PMID: 33300026    Free PMC article.
ADP-ribosylation of histone variant H2AX promotes base excision repair.
Qian Chen, Chunjing Bian, +4 authors, Xiaochun Yu.
EMBO J, 2020 Dec 03; 40(2). PMID: 33264433    Free PMC article.
New Prognostic Biomarkers in Metastatic Castration-Resistant Prostate Cancer.
Vincenza Conteduca, Alessandra Mosca, +2 authors, Pasquale Rescigno.
Cells, 2021 Jan 23; 10(1). PMID: 33478015    Free PMC article.
Review.
Effects of Gut Microbiome on Carcinogenic DNA Damage.
Yun-Chung Hsiao, Chih-Wei Liu, +2 authors, Kun Lu.
Chem Res Toxicol, 2020 Jul 18; 33(8). PMID: 32677427    Free PMC article.
SUMOylation mediates CtIP's functions in DNA end resection and replication fork protection.
Andrew J Locke, Lazina Hossain, +7 authors, Ismail Hassan Ismail.
Nucleic Acids Res, 2021 Jan 07; 49(2). PMID: 33406258    Free PMC article.
UV-exposure, endogenous DNA damage, and DNA replication errors shape the spectra of genome changes in human skin.
Natalie Saini, Camille K Giacobone, +9 authors, Dmitry A Gordenin.
PLoS Genet, 2021 Jan 15; 17(1). PMID: 33444353    Free PMC article.
BRCA1 and RNAi factors promote repair mediated by small RNAs and PALB2-RAD52.
Elodie Hatchi, Liana Goehring, +8 authors, David M Livingston.
Nature, 2021 Feb 05; 591(7851). PMID: 33536619
The Dark Side of the Force: When the Immune System Is the Fuel of Tumor Onset.
Elisabeth Digifico, Silvia Balinzo, Cristina Belgiovine.
Int J Mol Sci, 2021 Jan 31; 22(3). PMID: 33513730    Free PMC article.
Review.
The Interactions of DNA Repair, Telomere Homeostasis, and p53 Mutational Status in Solid Cancers: Risk, Prognosis, and Prediction.
Pavel Vodicka, Ladislav Andera, Alena Opattova, Ludmila Vodickova.
Cancers (Basel), 2021 Jan 31; 13(3). PMID: 33513745    Free PMC article.
Review.
DNA Damage Response in Multiple Myeloma: The Role of the Tumor Microenvironment.
Takayuki Saitoh, Tsukasa Oda.
Cancers (Basel), 2021 Feb 03; 13(3). PMID: 33525741    Free PMC article.
Review.
Arsenic hexoxide has differential effects on cell proliferation and genome-wide gene expression in human primary mammary epithelial and MCF7 cells.
Donguk Kim, Na Yeon Park, +4 authors, Heeyoun Bunch.
Sci Rep, 2021 Feb 14; 11(1). PMID: 33580144    Free PMC article.
RNA: a double-edged sword in genome maintenance.
Dali Zong, Philipp Oberdoerffer, Pedro J Batista, André Nussenzweig.
Nat Rev Genet, 2020 Aug 09; 21(11). PMID: 32764716
Review.
Base and Nucleotide Excision Repair Pathways in DNA Plasmids Harboring Oxidatively Generated Guanine Lesions.
Marina Kolbanovskiy, Abraham Aharonoff, +2 authors, Vladimir Shafirovich.
Chem Res Toxicol, 2021 Jan 07; 34(1). PMID: 33405911    Free PMC article.
Widespread Transcriptional Scanning in the Testis Modulates Gene Evolution Rates.
Bo Xia, Yun Yan, +8 authors, Itai Yanai.
Cell, 2020 Jan 25; 180(2). PMID: 31978344    Free PMC article.
Comet assay: a versatile but complex tool in genotoxicity testing.
Eugenia Cordelli, Margherita Bignami, Francesca Pacchierotti.
Toxicol Res (Camb), 2021 Feb 23; 10(1). PMID: 33613974    Free PMC article.
Review.
DNA-double strand breaks enhance the expression of major histocompatibility complex class II through the ATM-NF-κΒ-IRF1-CIITA pathway.
Tsukasa Oda, Ruri Nakamura, +6 authors, Takayuki Yamashita.
Cancer Gene Ther, 2021 Feb 24;. PMID: 33619341
Loss of Mediator complex subunit 13 (MED13) promotes resistance to alkylation through cyclin D1 upregulation.
Miłosz Roliński, Nicola Pietro Montaldo, +10 authors, Barbara van Loon.
Nucleic Acids Res, 2021 Jan 15; 49(3). PMID: 33444446    Free PMC article.
Towards a comprehensive view of 8-oxo-7,8-dihydro-2'-deoxyguanosine: Highlighting the intertwined roles of DNA damage and epigenetics in genomic instability.
Francesca Gorini, Giovanni Scala, +2 authors, Stefano Amente.
DNA Repair (Amst), 2020 Dec 08; 97. PMID: 33285475    Free PMC article.
Review.
A unique arginine cluster in PolDIP2 enhances nucleotide binding and DNA synthesis by PrimPol.
Kazutoshi Kasho, Gorazd Stojkovič, +8 authors, Sjoerd Wanrooij.
Nucleic Acids Res, 2021 Feb 04; 49(4). PMID: 33533925    Free PMC article.
The Multiple Cellular Roles of SMUG1 in Genome Maintenance and Cancer.
Sripriya Raja, Bennett Van Houten.
Int J Mol Sci, 2021 Mar 07; 22(4). PMID: 33671338    Free PMC article.
Review.
Human RecQ Helicases in DNA Double-Strand Break Repair.
Huiming Lu, Anthony J Davis.
Front Cell Dev Biol, 2021 Mar 16; 9. PMID: 33718381    Free PMC article.
Review.
Nbs1-mediated DNA damage repair pathway regulates haematopoietic stem cell development and embryonic haematopoiesis.
Yu Chen, Jie Sun, +2 authors, Tangliang Li.
Cell Prolif, 2021 Feb 16; 54(3). PMID: 33586242    Free PMC article.
The DNA damage response network in the treatment of head and neck squamous cell carcinoma.
A Psyrri, M Gkotzamanidou, +5 authors, V L Souliotis.
ESMO Open, 2021 Mar 14; 6(2). PMID: 33714009    Free PMC article.
Cancer-associated mutations in the condensin II subunit CAPH2 cause genomic instability through telomere dysfunction and anaphase chromosome bridges.
Emily Weyburne, Giovanni Bosco.
J Cell Physiol, 2020 Oct 21; 236(5). PMID: 33078399    Free PMC article.
Super-resolution mapping of cellular double-strand break resection complexes during homologous recombination.
Donna R Whelan, Eli Rothenberg.
Proc Natl Acad Sci U S A, 2021 Mar 13; 118(11). PMID: 33707212    Free PMC article.
Night shift schedule causes circadian dysregulation of DNA repair genes and elevated DNA damage in humans.
Bala S C Koritala, Kenneth I Porter, +8 authors, Shobhan Gaddameedhi.
J Pineal Res, 2021 Feb 28; 70(3). PMID: 33638890    Free PMC article.
Genetic variations in base excision repair pathway genes and risk of hepatoblastoma: a seven-center case-control study.
Zhenjian Zhuo, Ao Lin, +7 authors, Jing He.
Am J Cancer Res, 2021 Apr 02; 11(3). PMID: 33791158    Free PMC article.
Emerging roles of RNA modifications in genome integrity.
Seo Yun Lee, Jae Jin Kim, Kyle M Miller.
Brief Funct Genomics, 2020 Dec 07; 20(2). PMID: 33279952    Free PMC article.
BIR repeat-containing ubiquitin conjugating enzyme (BRUCE) regulation of β-catenin signaling in the progression of drug-induced hepatic fibrosis and carcinogenesis.
Chrystelle L Vilfranc, Li-Xiao Che, +5 authors, Chun-Ying Du.
World J Hepatol, 2021 Apr 06; 13(3). PMID: 33815677    Free PMC article.
Exons and introns exhibit transcriptional strand asymmetry of dinucleotide distribution, damage formation and DNA repair.
Elisheva E Heilbrun, May Merav, Sheera Adar.
NAR Genom Bioinform, 2021 Apr 06; 3(1). PMID: 33817640    Free PMC article.
Excision of Oxidatively Generated Guanine Lesions by Competitive DNA Repair Pathways.
Vladimir Shafirovich, Nicholas E Geacintov.
Int J Mol Sci, 2021 Apr 04; 22(5). PMID: 33800059    Free PMC article.
Review.
DNA Damage Response during Replication Correlates with CIN70 Score and Determines Survival in HNSCC Patients.
Ioan T Bold, Ann-Kathrin Specht, +8 authors, Kerstin Borgmann.
Cancers (Basel), 2021 Apr 04; 13(6). PMID: 33801877    Free PMC article.
Alternative Non-Homologous End-Joining: Error-Prone DNA Repair as Cancer's Achilles' Heel.
Daniele Caracciolo, Caterina Riillo, +2 authors, Pierfrancesco Tassone.
Cancers (Basel), 2021 Apr 04; 13(6). PMID: 33808562    Free PMC article.
Review.
Cell Metabolism and DNA Repair Pathways: Implications for Cancer Therapy.
Thais Sobanski, Maddison Rose, +3 authors, Emma Bolderson.
Front Cell Dev Biol, 2021 Apr 10; 9. PMID: 33834022    Free PMC article.
Review.
Association of genetic variants of TMEM135 and PEX5 in the peroxisome pathway with cutaneous melanoma-specific survival.
Haijiao Wang, Hongliang Liu, +7 authors, Qingyi Wei.
Ann Transl Med, 2021 Apr 13; 9(5). PMID: 33842617    Free PMC article.
Neuronal enhancers are hotspots for DNA single-strand break repair.
Wei Wu, Sarah E Hill, +22 authors, André Nussenzweig.
Nature, 2021 Mar 27; 593(7859). PMID: 33767446
Obese Adipose Tissue as a Driver of Breast Cancer Growth and Development: Update and Emerging Evidence.
Priya Bhardwaj, Kristy A Brown.
Front Oncol, 2021 Apr 17; 11. PMID: 33859943    Free PMC article.
Review.
The Multifunctional Protein p62 and Its Mechanistic Roles in Cancers.
Shunbin Ning, Ling Wang.
Curr Cancer Drug Targets, 2018 Oct 20; 19(6). PMID: 30332964    Free PMC article.
Review.
Imaging the response to DNA damage in heterochromatin domains reveals core principles of heterochromatin maintenance.
Anna Fortuny, Audrey Chansard, +4 authors, Sophie E Polo.
Nat Commun, 2021 Apr 25; 12(1). PMID: 33893291    Free PMC article.
A Link between Replicative Stress, Lamin Proteins, and Inflammation.
Simon Willaume, Emilie Rass, +3 authors, Pascale Bertrand.
Genes (Basel), 2021 May 01; 12(4). PMID: 33918867    Free PMC article.
Review.
Role of the DNA damage response in prostate cancer formation, progression and treatment.
Wenhao Zhang, Dik C van Gent, +2 authors, Julie Nonnekens.
Prostate Cancer Prostatic Dis, 2019 Jun 15; 23(1). PMID: 31197228    Free PMC article.
Genome instability and loss of protein homeostasis: converging paths to neurodegeneration?
Anna Ainslie, Wouter Huiting, Lara Barazzuol, Steven Bergink.
Open Biol, 2021 Apr 22; 11(4). PMID: 33878947    Free PMC article.
Sweet Melody or Jazz? Transcription Around DNA Double-Strand Breaks.
Qilin Long, Zhichao Liu, Monika Gullerova.
Front Mol Biosci, 2021 May 08; 8. PMID: 33959637    Free PMC article.
Review.
Ongoing repair of migration-coupled DNA damage allows planarian adult stem cells to reach wound sites.
Sounak Sahu, Divya Sridhar, +5 authors, Aziz Aboobaker.
Elife, 2021 Apr 24; 10. PMID: 33890575    Free PMC article.
Melatonin in Cancer Treatment: Current Knowledge and Future Opportunities.
Wamidh H Talib, Ahmad Riyad Alsayed, +2 authors, Asma Ismail Mahmod.
Molecules, 2021 May 01; 26(9). PMID: 33923028    Free PMC article.
Review.
Mouse Models for Deciphering the Impact of Homologous Recombination on Tumorigenesis.
Gabriel Matos-Rodrigues, Emmanuelle Martini, Bernard S Lopez.
Cancers (Basel), 2021 May 01; 13(9). PMID: 33923105    Free PMC article.
Review.
Genomic Instability in Multiple Myeloma: A "Non-Coding RNA" Perspective.
Elisa Taiana, Maria Eugenia Gallo Cantafio, +5 authors, Nicola Amodio.
Cancers (Basel), 2021 May 01; 13(9). PMID: 33924959    Free PMC article.
Review.
Poly(ADP-ribose) binding and macroH2A mediate recruitment and functions of KDM5A at DNA lesions.
Ramhari Kumbhar, Anthony Sanchez, +9 authors, Kyle M Miller.
J Cell Biol, 2021 May 19; 220(7). PMID: 34003252    Free PMC article.
Development and validation of a prognostic nomogram for patients with lung adenocarcinoma based on a novel 6-DNA repair-related gene signature.
Minjie Chen, Hui Dong, Shengchang Deng, Ying Zhou.
Am J Transl Res, 2021 May 22; 13(4). PMID: 34017369    Free PMC article.
m6A regulators are associated with osteosarcoma metastasis and have prognostic significance: A study based on public databases.
Wenpeng Zhang, Lina Wang, Ping Zhang, Quanbin Zhang.
Medicine (Baltimore), 2021 May 21; 100(20). PMID: 34011074    Free PMC article.
New Faces of old Friends: Emerging new Roles of RNA-Binding Proteins in the DNA Double-Strand Break Response.
Julie A Klaric, Stas Wüst, Stephanie Panier.
Front Mol Biosci, 2021 May 25; 8. PMID: 34026839    Free PMC article.
Review.
Molecular characterization of ctDNA from Chinese patients with advanced gastric adenocarcinoma reveals actionable alterations for targeted and immune therapy.
Meng Zhang, Changsong Qi, +8 authors, Jiafu Ji.
J Mol Med (Berl), 2021 Jun 01;. PMID: 34057552
Combined Targeting of PARG and Wee1 Causes Decreased Cell Survival and DNA Damage in an S-Phase-Dependent Manner.
Lebaron C Agostini, Aditi Jain, +5 authors, Jonathan R Brody.
Mol Cancer Res, 2020 Dec 02; 19(2). PMID: 33257507    Free PMC article.
The lipid peroxidation derived DNA adduct γ-OHPdG levels in paraneoplastic liver tissues predict postoperative outcomes of hepatoma.
Yang-Yi Feng, Jen Yu, +2 authors, Chau-Ting Yeh.
J Cancer, 2021 Jun 08; 12(13). PMID: 34093810    Free PMC article.
A nine-gene signature to improve prognosis prediction of colon carcinoma.
Jinlai Zhao, Yigang Wang, +4 authors, Hua Li.
Cell Cycle, 2021 May 15; 20(10). PMID: 33985413    Free PMC article.