Review
. 2017 Feb; 168(4):657-669.
doi: 10.1016/j.cell.2016.12.039.

Understanding the Intersections between Metabolism and Cancer Biology

Matthew G Vander Heiden 1 Ralph J DeBerardinis 2 
Affiliations
  • PMID: 28187287
  •     132 References
  •     494 citations

Abstract

Transformed cells adapt metabolism to support tumor initiation and progression. Specific metabolic activities can participate directly in the process of transformation or support the biological processes that enable tumor growth. Exploiting cancer metabolism for clinical benefit requires defining the pathways that are limiting for cancer progression and understanding the context specificity of metabolic preferences and liabilities in malignant cells. Progress toward answering these questions is providing new insight into cancer biology and can guide the more effective targeting of metabolism to help patients.

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Proc Natl Acad Sci U S A, 2014 Jul 09; 111(29). PMID: 25002509    Free PMC article.
Highly Cited.
Fructose-1,6-bisphosphatase opposes renal carcinoma progression.
Bo Li, Bo Qiu, +8 authors, M Celeste Simon.
Nature, 2014 Jul 22; 513(7517). PMID: 25043030    Free PMC article.
Highly Cited.
Chronic oxidative stress and radiation-induced late normal tissue injury: a review.
M E C Robbins, W Zhao.
Int J Radiat Biol, 2004 Jun 19; 80(4). PMID: 15204702
Review.
Fumarate induces redox-dependent senescence by modifying glutathione metabolism.
Liang Zheng, Simone Cardaci, +14 authors, Eyal Gottlieb.
Nat Commun, 2015 Jan 24; 6. PMID: 25613188    Free PMC article.
Highly Cited.
Metabolic modulation of glioblastoma with dichloroacetate.
E D Michelakis, G Sutendra, +10 authors, K C Petruk.
Sci Transl Med, 2010 May 14; 2(31). PMID: 20463368
Highly Cited.
Metformin inhibits mitochondrial complex I of cancer cells to reduce tumorigenesis.
William W Wheaton, Samuel E Weinberg, +8 authors, Navdeep S Chandel.
Elife, 2014 May 21; 3. PMID: 24843020    Free PMC article.
Highly Cited.
Effects of living at higher altitudes on mortality: a narrative review.
Martin Burtscher.
Aging Dis, 2014 Aug 12; 5(4). PMID: 25110611    Free PMC article.
Review.
What a difference a hydroxyl makes: mutant IDH, (R)-2-hydroxyglutarate, and cancer.
Julie-Aurore Losman, William G Kaelin.
Genes Dev, 2013 May 01; 27(8). PMID: 23630074    Free PMC article.
Highly Cited. Review.
Extreme Vulnerability of IDH1 Mutant Cancers to NAD+ Depletion.
Kensuke Tateishi, Hiroaki Wakimoto, +26 authors, Daniel P Cahill.
Cancer Cell, 2015 Dec 19; 28(6). PMID: 26678339    Free PMC article.
Highly Cited.
Epithelial-Mesenchymal Plasticity: A Central Regulator of Cancer Progression.
Xin Ye, Robert A Weinberg.
Trends Cell Biol, 2015 Oct 07; 25(11). PMID: 26437589    Free PMC article.
Highly Cited. Review.
Supporting Aspartate Biosynthesis Is an Essential Function of Respiration in Proliferating Cells.
Lucas B Sullivan, Dan Y Gui, +3 authors, Matthew G Vander Heiden.
Cell, 2015 Aug 02; 162(3). PMID: 26232225    Free PMC article.
Highly Cited.
Tissue of origin dictates branched-chain amino acid metabolism in mutant Kras-driven cancers.
Jared R Mayers, Margaret E Torrence, +14 authors, Matthew G Vander Heiden.
Science, 2016 Sep 10; 353(6304). PMID: 27609895    Free PMC article.
Highly Cited.
LKB1 inactivation dictates therapeutic response of non-small cell lung cancer to the metabolism drug phenformin.
David B Shackelford, Evan Abt, +8 authors, Reuben J Shaw.
Cancer Cell, 2013 Jan 29; 23(2). PMID: 23352126    Free PMC article.
Highly Cited.
Autophagy provides metabolic substrates to maintain energy charge and nucleotide pools in Ras-driven lung cancer cells.
Jessie Yanxiang Guo, Xin Teng, +7 authors, Eileen White.
Genes Dev, 2016 Aug 16; 30(15). PMID: 27516533    Free PMC article.
Highly Cited.
LDHA-Associated Lactic Acid Production Blunts Tumor Immunosurveillance by T and NK Cells.
Almut Brand, Katrin Singer, +36 authors, Marina Kreutz.
Cell Metab, 2016 Sep 20; 24(5). PMID: 27641098
Highly Cited.
Oncogene ablation-resistant pancreatic cancer cells depend on mitochondrial function.
Andrea Viale, Piergiorgio Pettazzoni, +27 authors, Giulio F Draetta.
Nature, 2014 Aug 15; 514(7524). PMID: 25119024    Free PMC article.
Highly Cited.
Stromal control of cystine metabolism promotes cancer cell survival in chronic lymphocytic leukaemia.
Wan Zhang, Dunyaporn Trachootham, +9 authors, Peng Huang.
Nat Cell Biol, 2012 Feb 22; 14(3). PMID: 22344033    Free PMC article.
Highly Cited.
Mutant IDH inhibits HNF-4α to block hepatocyte differentiation and promote biliary cancer.
Supriya K Saha, Christine A Parachoniak, +23 authors, Nabeel Bardeesy.
Nature, 2014 Jul 22; 513(7516). PMID: 25043045    Free PMC article.
Highly Cited.
DHODH modulates transcriptional elongation in the neural crest and melanoma.
Richard Mark White, Jennifer Cech, +17 authors, Leonard I Zon.
Nature, 2011 Mar 25; 471(7339). PMID: 21430780    Free PMC article.
Highly Cited.
Bacterial community morphogenesis is intimately linked to the intracellular redox state.
Lars E P Dietrich, Chinweike Okegbe, +3 authors, Dianne K Newman.
J Bacteriol, 2013 Jan 08; 195(7). PMID: 23292774    Free PMC article.
Highly Cited.
Metabolism of pyruvate by isolated rat mesenteric lymphocytes, lymphocyte mitochondria and isolated mouse macrophages.
R Curi, P Newsholme, E A Newsholme.
Biochem J, 1988 Mar 01; 250(2). PMID: 3128282    Free PMC article.
HIF2α-Dependent Lipid Storage Promotes Endoplasmic Reticulum Homeostasis in Clear-Cell Renal Cell Carcinoma.
Bo Qiu, Daniel Ackerman, +7 authors, M Celeste Simon.
Cancer Discov, 2015 Apr 02; 5(6). PMID: 25829424    Free PMC article.
Highly Cited.
Metabolic reprogramming during TGFβ1-induced epithelial-to-mesenchymal transition.
L Jiang, L Xiao, +5 authors, D A Boothman.
Oncogene, 2014 Oct 07; 34(30). PMID: 25284588    Free PMC article.
Metabolism of [U-13 C]glucose in human brain tumors in vivo.
Elizabeth A Maher, Isaac Marin-Valencia, +12 authors, Ralph J DeBerardinis.
NMR Biomed, 2012 Mar 16; 25(11). PMID: 22419606    Free PMC article.
Highly Cited.
A growing role for mTOR in promoting anabolic metabolism.
Jessica J Howell, Stéphane J H Ricoult, Issam Ben-Sahra, Brendan D Manning.
Biochem Soc Trans, 2013 Jul 19; 41(4). PMID: 23863154
Highly Cited. Review.
Suppression of nucleotide metabolism underlies the establishment and maintenance of oncogene-induced senescence.
Katherine M Aird, Gao Zhang, +8 authors, Rugang Zhang.
Cell Rep, 2013 Apr 09; 3(4). PMID: 23562156    Free PMC article.
Highly Cited.
Metabolomics reveals intratumor heterogeneity - Implications for precision medicine.
Xiaojing Liu, Jason W Locasale.
EBioMedicine, 2017 May 02; 19. PMID: 28457617    Free PMC article.
Autophagy and Tumor Metabolism.
Alec C Kimmelman, Eileen White.
Cell Metab, 2017 May 04; 25(5). PMID: 28467923    Free PMC article.
Highly Cited. Review.
Biochemical Underpinnings of Immune Cell Metabolic Phenotypes.
Benjamin A Olenchock, Jeffrey C Rathmell, Matthew G Vander Heiden.
Immunity, 2017 May 18; 46(5). PMID: 28514672    Free PMC article.
Highly Cited. Review.
Exploiting ROS and metabolic differences to kill cisplatin resistant lung cancer.
Medhi Wangpaichitr, Chunjing Wu, +8 authors, Niramol Savaraj.
Oncotarget, 2017 May 20; 8(30). PMID: 28525376    Free PMC article.
The glutamate/cystine antiporter SLC7A11/xCT enhances cancer cell dependency on glucose by exporting glutamate.
Pranavi Koppula, Yilei Zhang, +2 authors, Boyi Gan.
J Biol Chem, 2017 Jun 21; 292(34). PMID: 28630042    Free PMC article.
Highly Cited.
Cell state plasticity, stem cells, EMT, and the generation of intra-tumoral heterogeneity.
Geoffrey M Wahl, Benjamin T Spike.
NPJ Breast Cancer, 2017 Jun 27; 3. PMID: 28649654    Free PMC article.
Highly Cited.
Replication Study: The common feature of leukemia-associated IDH1 and IDH2 mutations is a neomorphic enzyme activity converting alpha-ketoglutarate to 2-hydroxyglutarate.
Megan Reed Showalter, Jason Hatakeyama, +4 authors, Reproducibility Project: Cancer Biology.
Elife, 2017 Jun 28; 6. PMID: 28653623    Free PMC article.
Warburg's vision.
James B Hurley.
Elife, 2017 Jul 07; 6. PMID: 28681722    Free PMC article.
Extracellular vesicles: Taking metabolism on the road.
Lucas B Sullivan.
Nat Chem Biol, 2017 Aug 19; 13(9). PMID: 28820875
Environmental cystine drives glutamine anaplerosis and sensitizes cancer cells to glutaminase inhibition.
Alexander Muir, Laura V Danai, +3 authors, Matthew G Vander Heiden.
Elife, 2017 Aug 23; 6. PMID: 28826492    Free PMC article.
Highly Cited.
Looking to the metabolic landscapes for prostate health monitoring.
Wun-Jae Kim, Jayoung Kim.
Prostate Int, 2017 Aug 23; 5(3). PMID: 28828350    Free PMC article.
Review.
Identification of the Consistently Altered Metabolic Targets in Human Hepatocellular Carcinoma.
Zeribe Chike Nwosu, Dominik Andre Megger, +5 authors, Steven Dooley.
Cell Mol Gastroenterol Hepatol, 2017 Aug 26; 4(2). PMID: 28840186    Free PMC article.
Nitric Oxide: The Forgotten Child of Tumor Metabolism.
Bahar Salimian Rizi, Abhinav Achreja, Deepak Nagrath.
Trends Cancer, 2017 Sep 05; 3(9). PMID: 28867169    Free PMC article.
Review.
A Predictive Model for Selective Targeting of the Warburg Effect through GAPDH Inhibition with a Natural Product.
Maria V Liberti, Ziwei Dai, +14 authors, Jason W Locasale.
Cell Metab, 2017 Sep 19; 26(4). PMID: 28918937    Free PMC article.
Highly Cited.
Targeting Metabolism for Cancer Therapy.
Alba Luengo, Dan Y Gui, Matthew G Vander Heiden.
Cell Chem Biol, 2017 Sep 25; 24(9). PMID: 28938091    Free PMC article.
Highly Cited. Review.
Obesity and Cancer Metabolism: A Perspective on Interacting Tumor-Intrinsic and Extrinsic Factors.
Steven S Doerstling, Ciara H O'Flanagan, Stephen D Hursting.
Front Oncol, 2017 Sep 30; 7. PMID: 28959684    Free PMC article.
Review.
Activation of the NRF2 antioxidant program generates an imbalance in central carbon metabolism in cancer.
Volkan I Sayin, Sarah E LeBoeuf, +15 authors, Thales Papagiannakopoulos.
Elife, 2017 Oct 03; 6. PMID: 28967864    Free PMC article.
Highly Cited.
Lactate Metabolism in Human Lung Tumors.
Brandon Faubert, Kevin Y Li, +21 authors, Ralph J DeBerardinis.
Cell, 2017 Oct 07; 171(2). PMID: 28985563    Free PMC article.
Highly Cited.
The impact of cellular metabolism on chromatin dynamics and epigenetics.
Michael A Reid, Ziwei Dai, Jason W Locasale.
Nat Cell Biol, 2017 Oct 24; 19(11). PMID: 29058720    Free PMC article.
Highly Cited. Review.
Metabolomics guided pathway analysis reveals link between cancer metastasis, cholesterol sulfate, and phospholipids.
Caroline H Johnson, Antonio F Santidrian, +11 authors, Gary Siuzdak.
Cancer Metab, 2017 Nov 03; 5. PMID: 29093815    Free PMC article.
Pyrimidine metabolic rate limiting enzymes in poorly-differentiated hepatocellular carcinoma are signature genes of cancer stemness and associated with poor prognosis.
Hsi-Wen Yeh, Szu-Shuo Lee, +2 authors, Yuh-Shan Jou.
Oncotarget, 2017 Nov 05; 8(44). PMID: 29100421    Free PMC article.
Comprehensive Characterization of Alternative Polyadenylation in Human Cancer.
Yu Xiang, Youqiong Ye, +17 authors, Leng Han.
J Natl Cancer Inst, 2017 Nov 07; 110(4). PMID: 29106591    Free PMC article.
Cancer Metabolism and Tumor Heterogeneity: Imaging Perspectives Using MR Imaging and Spectroscopy.
Gigin Lin, Kayvan R Keshari, Jae Mo Park.
Contrast Media Mol Imaging, 2017 Nov 09; 2017. PMID: 29114178    Free PMC article.
Review.
CDK8 Kinase Activity Promotes Glycolysis.
Matthew D Galbraith, Zdenek Andrysik, +5 authors, Joaquín M Espinosa.
Cell Rep, 2017 Nov 09; 21(6). PMID: 29117556    Free PMC article.
Systems Biology Approaches to Redox Metabolism in Stress and Disease States.
Rui-Sheng Wang, William M Oldham, Bradley A Maron, Joseph Loscalzo.
Antioxid Redox Signal, 2017 Nov 11; 29(10). PMID: 29121773    Free PMC article.
Review.
Molecular determinants of prostate cancer metastasis.
Kiera Rycaj, Dean G Tang.
Oncotarget, 2017 Nov 21; 8(50). PMID: 29152153    Free PMC article.
Review.
Reverse engineering the cancer metabolic network using flux analysis to understand drivers of human disease.
Mehmet G Badur, Christian M Metallo.
Metab Eng, 2017 Dec 05; 45. PMID: 29199104    Free PMC article.
Review.
A New Perspective on the Heterogeneity of Cancer Glycolysis.
Michael L Neugent, Justin Goodwin, +3 authors, Jung-Whan Kim.
Biomol Ther (Seoul), 2017 Dec 08; 26(1). PMID: 29212302    Free PMC article.
Review.
Metabolic Signaling to Epigenetic Alterations in Cancer.
Jung-Ae Kim, Young Il Yeom.
Biomol Ther (Seoul), 2017 Dec 08; 26(1). PMID: 29212308    Free PMC article.
Review.
Imaging Cancer Metabolism.
Milica Momcilovic, David B Shackelford.
Biomol Ther (Seoul), 2017 Dec 08; 26(1). PMID: 29212309    Free PMC article.
Review.
Ataxia-Telangiectasia Mutated Modulation of Carbon Metabolism in Cancer.
Erika S Dahl, Katherine M Aird.
Front Oncol, 2017 Dec 15; 7. PMID: 29238697    Free PMC article.
Review.
A novel small-molecule arylsulfonamide causes energetic stress and suppresses breast and lung tumor growth and metastasis.
Xin Dai, Stefan Kaluz, +6 authors, Chalet Tan.
Oncotarget, 2017 Dec 17; 8(59). PMID: 29245898    Free PMC article.
Oncogenic PI3K promotes methionine dependency in breast cancer cells through the cystine-glutamate antiporter xCT.
Evan C Lien, Laura Ghisolfi, +2 authors, Alex Toker.
Sci Signal, 2017 Dec 21; 10(510). PMID: 29259101    Free PMC article.
A molecular signature of lung cancer: potential biomarkers for adenocarcinoma and squamous cell carcinoma.
Varda Shoshan-Barmatz, Yael Bishitz, +6 authors, Yael Refaely.
Oncotarget, 2017 Dec 30; 8(62). PMID: 29285267    Free PMC article.
Amino acid and small GTPase regulation of mTORC1.
Thu P Nguyen, Anderson R Frank, Jenna L Jewell.
Cell Logist, 2018 Jan 04; 7(4). PMID: 29296509    Free PMC article.
Review.
FoxO transcription factors in cancer metabolism.
Raj Kumar Yadav, Anoop Singh Chauhan, Li Zhuang, Boyi Gan.
Semin Cancer Biol, 2018 Jan 09; 50. PMID: 29309929    Free PMC article.
Review.
Metabolic Barriers to T Cell Function in Tumors.
Ayaka Sugiura, Jeffrey C Rathmell.
J Immunol, 2018 Jan 10; 200(2). PMID: 29311381    Free PMC article.
Highly Cited. Review.
Editorial: Metabolic Adaptation to Cell Growth and Proliferation in Normal and Pathological Conditions.
Albert Giralt, Lluis Fajas.
Front Endocrinol (Lausanne), 2018 Jan 10; 8. PMID: 29312151    Free PMC article.
As Extracellular Glutamine Levels Decline, Asparagine Becomes an Essential Amino Acid.
Natalya N Pavlova, Sheng Hui, +6 authors, Ji Zhang.
Cell Metab, 2018 Jan 18; 27(2). PMID: 29337136    Free PMC article.
Highly Cited.
Mechanisms of redox metabolism and cancer cell survival during extracellular matrix detachment.
Mark A Hawk, Zachary T Schafer.
J Biol Chem, 2018 Jan 18; 293(20). PMID: 29339552    Free PMC article.
Review.
The redox requirements of proliferating mammalian cells.
Aaron M Hosios, Matthew G Vander Heiden.
J Biol Chem, 2018 Jan 18; 293(20). PMID: 29339555    Free PMC article.
Review.
Metabolism and Transcription in Cancer: Merging Two Classic Tales.
Natalia Martín-Martín, Arkaitz Carracedo, Verónica Torrano.
Front Cell Dev Biol, 2018 Jan 23; 5. PMID: 29354634    Free PMC article.
Review.
Phosphoglyceric acid mutase-1 contributes to oncogenic mTOR-mediated tumor growth and confers non-small cell lung cancer patients with poor prognosis.
Qian Sun, Shuzhan Li, +16 authors, Hongbing Zhang.
Cell Death Differ, 2018 Jan 25; 25(6). PMID: 29362480    Free PMC article.
LPA Induces Metabolic Reprogramming in Ovarian Cancer via a Pseudohypoxic Response.
Ji Hee Ha, Rangasudhagar Radhakrishnan, +9 authors, Danny N Dhanasekaran.
Cancer Res, 2018 Feb 02; 78(8). PMID: 29386184    Free PMC article.
COBRA methods and metabolic drug targets in cancer.
Iñigo Apaolaza, Edurne San José-Eneriz, +2 authors, Francisco J Planes.
Mol Cell Oncol, 2018 Feb 07; 5(1). PMID: 29404389    Free PMC article.
Identification of genomic expression differences between right-sided and left-sided colon cancer based on bioinformatics analysis.
Qiliang Peng, Kaisu Lin, +4 authors, Yaqun Zhu.
Onco Targets Ther, 2018 Feb 13; 11. PMID: 29430186    Free PMC article.
Lipid metabolism and lipophagy in cancer.
Meenu Maan, Jeffrey M Peters, Mainak Dutta, Andrew D Patterson.
Biochem Biophys Res Commun, 2018 Feb 14; 504(3). PMID: 29438712    Free PMC article.
Review.
Redox responses are preserved across muscle fibres with differential susceptibility to aging.
Neil T Smith, Ana Soriano-Arroquia, +2 authors, Brian McDonagh.
J Proteomics, 2018 Feb 14; 177. PMID: 29438851    Free PMC article.
Uncoupling FoxO3A mitochondrial and nuclear functions in cancer cells undergoing metabolic stress and chemotherapy.
Valentina Celestini, Tugsan Tezil, +17 authors, Cristiano Simone.
Cell Death Dis, 2018 Feb 16; 9(2). PMID: 29445193    Free PMC article.
A human-specific switch of alternatively spliced AFMID isoforms contributes to TP53 mutations and tumor recurrence in hepatocellular carcinoma.
Kuan-Ting Lin, Wai Kit Ma, +2 authors, Adrian R Krainer.
Genome Res, 2018 Feb 17;. PMID: 29449409    Free PMC article.
Serine Catabolism by SHMT2 Is Required for Proper Mitochondrial Translation Initiation and Maintenance of Formylmethionyl-tRNAs.
Denise R Minton, Minwoo Nam, +8 authors, Richard Possemato.
Mol Cell, 2018 Feb 18; 69(4). PMID: 29452640    Free PMC article.
Highly Cited.
Oncoprotein CIP2A promotes the disassembly of primary cilia and inhibits glycolytic metabolism.
Ae Lee Jeong, Hye In Ka, +10 authors, Young Yang.
EMBO Rep, 2018 Mar 02; 19(5). PMID: 29491003    Free PMC article.
Colorectal Tumors Require NUAK1 for Protection from Oxidative Stress.
Jennifer Port, Nathiya Muthalagu, +22 authors, Daniel J Murphy.
Cancer Discov, 2018 Mar 04; 8(5). PMID: 29500295    Free PMC article.
Revisiting the Crabtree/Warburg effect in a dynamic perspective: a fitness advantage against sugar-induced cell death.
Elisabetta de Alteriis, Fabrizio Cartenì, +2 authors, Stefano Mazzoleni.
Cell Cycle, 2018 Mar 07; 17(6). PMID: 29509056    Free PMC article.
Review.
Coordinated Regulation of Metabolic Transporters and Migration/Invasion by Carbonic Anhydrase IX.
Paul C McDonald, Mridula Swayampakula, Shoukat Dedhar.
Metabolites, 2018 Mar 09; 8(1). PMID: 29517989    Free PMC article.
Review.
Elucidating the Metabolic Plasticity of Cancer: Mitochondrial Reprogramming and Hybrid Metabolic States.
Dongya Jia, Jun Hyoung Park, +2 authors, Benny Abraham Kaipparettu.
Cells, 2018 Mar 14; 7(3). PMID: 29534029    Free PMC article.
Highly Cited. Review.
Reprogrammed lipid metabolism in bladder cancer with cisplatin resistance.
Min Young Lee, Austin Yeon, +5 authors, Jayoung Kim.
Oncotarget, 2018 Mar 24; 9(17). PMID: 29568353    Free PMC article.
Molecular Characterization and Clinical Relevance of Metabolic Expression Subtypes in Human Cancers.
Xinxin Peng, Zhongyuan Chen, +19 authors, Han Liang.
Cell Rep, 2018 Apr 05; 23(1). PMID: 29617665    Free PMC article.
Highly Cited.
Deciphering the Dichotomous Effects of PGC-1α on Tumorigenesis and Metastasis.
Simon-Pierre Gravel.
Front Oncol, 2018 Apr 10; 8. PMID: 29629336    Free PMC article.
Review.
A guide to 13C metabolic flux analysis for the cancer biologist.
Maciek R Antoniewicz.
Exp Mol Med, 2018 Apr 17; 50(4). PMID: 29657327    Free PMC article.
Highly Cited. Review.
Expanding the concepts of cancer metabolism.
Sang-Min Jeon, Nissim Hay.
Exp Mol Med, 2018 Apr 17; 50(4). PMID: 29657329    Free PMC article.
Applications of metabolomics to study cancer metabolism.
Akash K Kaushik, Ralph J DeBerardinis.
Biochim Biophys Acta Rev Cancer, 2018 Apr 28; 1870(1). PMID: 29702206    Free PMC article.
Review.
Myoferlin controls mitochondrial structure and activity in pancreatic ductal adenocarcinoma, and affects tumor aggressiveness.
Gilles Rademaker, Vincent Hennequière, +16 authors, Olivier Peulen.
Oncogene, 2018 May 04; 37(32). PMID: 29720728    Free PMC article.
The contributions of cancer cell metabolism to metastasis.
Gloria Pascual, Diana Domínguez, Salvador Aznar Benitah.
Dis Model Mech, 2018 May 10; 11(8). PMID: 29739810    Free PMC article.
Review.
Signaling Pathways Regulating Redox Balance in Cancer Metabolism.
Maria Chiara De Santis, Paolo Ettore Porporato, Miriam Martini, Andrea Morandi.
Front Oncol, 2018 May 10; 8. PMID: 29740540    Free PMC article.
Review.
Fueling thought: Management of glycolysis and oxidative phosphorylation in neuronal metabolism.
Gary Yellen.
J Cell Biol, 2018 May 13; 217(7). PMID: 29752396    Free PMC article.
Highly Cited. Review.
Arginase 2 Suppresses Renal Carcinoma Progression via Biosynthetic Cofactor Pyridoxal Phosphate Depletion and Increased Polyamine Toxicity.
Joshua D Ochocki, Sanika Khare, +16 authors, M Celeste Simon.
Cell Metab, 2018 May 15; 27(6). PMID: 29754953    Free PMC article.
Targeting cancer's metabolic co-dependencies: A landscape shaped by genotype and tissue context.
Junfeng Bi, Sihan Wu, Wenjing Zhang, Paul S Mischel.
Biochim Biophys Acta Rev Cancer, 2018 May 19; 1870(1). PMID: 29775654    Free PMC article.
Review.
Quantification of Cellular Folate Species by LC-MS after Stabilization by Derivatization.
Matthias Schittmayer, Ruth Birner-Gruenberger, Nicola Zamboni.
Anal Chem, 2018 May 25; 90(12). PMID: 29792680    Free PMC article.
Intravital imaging by simultaneous label-free autofluorescence-multiharmonic microscopy.
Sixian You, Haohua Tu, +8 authors, Stephen A Boppart.
Nat Commun, 2018 May 31; 9(1). PMID: 29844371    Free PMC article.
Highly Cited.
Aspartate is an endogenous metabolic limitation for tumour growth.
Lucas B Sullivan, Alba Luengo, +8 authors, Matthew G Vander Heiden.
Nat Cell Biol, 2018 Jun 27; 20(7). PMID: 29941931    Free PMC article.
Highly Cited.
Four Key Steps Control Glycolytic Flux in Mammalian Cells.
Lukas Bahati Tanner, Alexander G Goglia, +6 authors, Joshua D Rabinowitz.
Cell Syst, 2018 Jul 02; 7(1). PMID: 29960885    Free PMC article.
Highly Cited.
Actionable Metabolic Pathways in Heart Failure and Cancer-Lessons From Cancer Cell Metabolism.
Anja Karlstaedt, Walter Schiffer, Heinrich Taegtmeyer.
Front Cardiovasc Med, 2018 Jul 05; 5. PMID: 29971237    Free PMC article.
Review.
Weak HIF-1alpha expression indicates poor prognosis in resectable pancreatic ductal adenocarcinoma.
Joni Leppänen, Olli Helminen, +7 authors, Tuomo J Karttunen.
World J Surg Oncol, 2018 Jul 06; 16(1). PMID: 29973215    Free PMC article.
α-ketoglutarate dehydrogenase inhibition counteracts breast cancer-associated lung metastasis.
Sandra Atlante, Alessia Visintin, +13 authors, Carlo Gaetano.
Cell Death Dis, 2018 Jul 11; 9(7). PMID: 29988033    Free PMC article.
A precision therapeutic strategy for hexokinase 1-null, hexokinase 2-positive cancers.
Shili Xu, Arthur Catapang, +7 authors, Harvey R Herschman.
Cancer Metab, 2018 Jul 11; 6. PMID: 29988332    Free PMC article.
Editorial: Cell Stress, Metabolic Reprogramming, and Cancer.
Sergio Giannattasio, Mario G Mirisola, Cristina Mazzoni.
Front Oncol, 2018 Jul 11; 8. PMID: 29988568    Free PMC article.
Pyruvate carboxylase supports the pulmonary tropism of metastatic breast cancer.
Aparna Shinde, Tomasz Wilmanski, +2 authors, Michael K Wendt.
Breast Cancer Res, 2018 Jul 15; 20(1). PMID: 30005601    Free PMC article.
The Circadian Clock Regulates Metabolic Phenotype Rewiring Via HKDC1 and Modulates Tumor Progression and Drug Response in Colorectal Cancer.
Luise Fuhr, Rukeia El-Athman, +12 authors, Angela Relógio.
EBioMedicine, 2018 Jul 15; 33. PMID: 30005951    Free PMC article.
Inosine Monophosphate Dehydrogenase Dependence in a Subset of Small Cell Lung Cancers.
Fang Huang, Min Ni, +16 authors, Ralph J DeBerardinis.
Cell Metab, 2018 Jul 26; 28(3). PMID: 30043754    Free PMC article.
Highly Cited.
Utilizing 18F-FDG PET/CT Imaging and Quantitative Histology to Measure Dynamic Changes in the Glucose Metabolism in Mouse Models of Lung Cancer.
Milica Momcilovic, Sean T Bailey, +6 authors, David B Shackelford.
J Vis Exp, 2018 Aug 07; (137). PMID: 30080208    Free PMC article.
Interplay between base excision repair protein XRCC1 and ALDH2 predicts overall survival in lung and liver cancer patients.
Xin Chen, Arnaud J Legrand, +6 authors, Grigory L Dianov.
Cell Oncol (Dordr), 2018 Aug 09; 41(5). PMID: 30088263    Free PMC article.
AIF promotes a JNK1-mediated cadherin switch independently of respiratory chain stabilization.
Andrew J Scott, Sierra A Walker, +4 authors, John C Wilkinson.
J Biol Chem, 2018 Aug 11; 293(38). PMID: 30093403    Free PMC article.
A pan-cancer study of the transcriptional regulation of uricogenesis in human tumours: pathological and pharmacological correlates.
Zuzana Saidak, Christophe Louandre, +6 authors, Antoine Galmiche.
Biosci Rep, 2018 Aug 15; 38(5). PMID: 30104401    Free PMC article.
Potential Mechanisms Connecting Purine Metabolism and Cancer Therapy.
Jie Yin, Wenkai Ren, +3 authors, Yulong Yin.
Front Immunol, 2018 Aug 15; 9. PMID: 30105018    Free PMC article.
Review.
Metformin as an Anticancer Agent.
Ales Vancura, Pengli Bu, +2 authors, Ivana Vancurova.
Trends Pharmacol Sci, 2018 Aug 29; 39(10). PMID: 30150001    Free PMC article.
Highly Cited. Review.
The big picture: exploring the metabolic cross-talk in cancer.
Almut Schulze, Mariia Yuneva.
Dis Model Mech, 2018 Aug 30; 11(8). PMID: 30154190    Free PMC article.
Double genetic disruption of lactate dehydrogenases A and B is required to ablate the "Warburg effect" restricting tumor growth to oxidative metabolism.
Maša Ždralević, Almut Brand, +17 authors, Marina Kreutz.
J Biol Chem, 2018 Aug 31; 293(41). PMID: 30158244    Free PMC article.
Metabolomic analysis of uterine serous carcinoma with acquired resistance to paclitaxel.
Manabu Seino, Tsuyoshi Ohta, +8 authors, Satoru Nagase.
Oncotarget, 2018 Sep 04; 9(62). PMID: 30174791    Free PMC article.
Fueling the Cycle: CDKs in Carbon and Energy Metabolism.
Maria Solaki, Jennifer C Ewald.
Front Cell Dev Biol, 2018 Sep 04; 6. PMID: 30175098    Free PMC article.
Review.
Liver cancer cell lines distinctly mimic the metabolic gene expression pattern of the corresponding human tumours.
Zeribe C Nwosu, Nadia Battello, +9 authors, Steven Dooley.
J Exp Clin Cancer Res, 2018 Sep 05; 37(1). PMID: 30176945    Free PMC article.
Triglycerides Promote Lipid Homeostasis during Hypoxic Stress by Balancing Fatty Acid Saturation.
Daniel Ackerman, Sergey Tumanov, +6 authors, Jurre J Kamphorst.
Cell Rep, 2018 Sep 06; 24(10). PMID: 30184495    Free PMC article.
Highly Cited.
mTORC2 modulates the amplitude and duration of GFAT1 Ser-243 phosphorylation to maintain flux through the hexosamine pathway during starvation.
Joseph G Moloughney, Nicole M Vega-Cotto, +10 authors, Estela Jacinto.
J Biol Chem, 2018 Sep 12; 293(42). PMID: 30201609    Free PMC article.
Malic Enzyme 1 (ME1) is pro-oncogenic in ApcMin/+ mice.
Lorenzo M Fernandes, Ahmed Al-Dwairi, +4 authors, Frank A Simmen.
Sci Rep, 2018 Sep 27; 8(1). PMID: 30250042    Free PMC article.
Redox regulation of pyruvate kinase M2 by cysteine oxidation and S-nitrosation.
Alice Rose Mitchell, Meng Yuan, +9 authors, Malcolm D Walkinshaw.
Biochem J, 2018 Sep 27; 475(20). PMID: 30254098    Free PMC article.
Metabolic Targeting of Breast Cancer Cells With the 2-Deoxy-D-Glucose and the Mitochondrial Bioenergetics Inhibitor MDIVI-1.
Federico Lucantoni, Heiko Dussmann, Jochen H M Prehn.
Front Cell Dev Biol, 2018 Sep 27; 6. PMID: 30255019    Free PMC article.
Epigenetics and Metabolism in Health and Disease.
Evangelia Tzika, Tobias Dreker, Axel Imhof.
Front Genet, 2018 Oct 04; 9. PMID: 30279699    Free PMC article.
Biosynthetic energy cost for amino acids decreases in cancer evolution.
Hong Zhang, Yirong Wang, +5 authors, Jian Lu.
Nat Commun, 2018 Oct 10; 9(1). PMID: 30297703    Free PMC article.
The Krebs Cycle Connection: Reciprocal Influence Between Alternative Splicing Programs and Cell Metabolism.
Giuseppe Biamonti, Lucia Maita, Alessandra Montecucco.
Front Oncol, 2018 Oct 16; 8. PMID: 30319972    Free PMC article.
Review.
The p38α Stress Kinase Suppresses Aneuploidy Tolerance by Inhibiting Hif-1α.
Susana Simões-Sousa, Samantha Littler, +15 authors, Stephen S Taylor.
Cell Rep, 2018 Oct 18; 25(3). PMID: 30332653    Free PMC article.
Metabolic reprogramming by Dichloroacetic acid potentiates photodynamic therapy of human breast adenocarcinoma MCF-7 cells.
Zeiyad Alkarakooly, Qudes A Al-Anbaky, Krishnaswamy Kannan, Nawab Ali.
PLoS One, 2018 Oct 24; 13(10). PMID: 30352078    Free PMC article.
Stable Isotope Labeling Highlights Enhanced Fatty Acid and Lipid Metabolism in Human Acute Myeloid Leukemia.
Lucille Stuani, Fabien Riols, +10 authors, Justine Bertrand-Michel.
Int J Mol Sci, 2018 Oct 28; 19(11). PMID: 30366412    Free PMC article.
PGC-1α as a Pivotal Factor in Lipid and Metabolic Regulation.
Ching-Feng Cheng, Hui-Chen Ku, Heng Lin.
Int J Mol Sci, 2018 Nov 08; 19(11). PMID: 30400212    Free PMC article.
Review.
Aglycemic HepG2 Cells Switch From Aminotransferase Glutaminolytic Pathway of Pyruvate Utilization to Complete Krebs Cycle at Hypoxia.
Jan Ježek, Lydie Plecitá-Hlavatá, Petr Ježek.
Front Endocrinol (Lausanne), 2018 Nov 13; 9. PMID: 30416487    Free PMC article.
Combined Metabolic Targeting With Metformin and the NSAIDs Diflunisal and Diclofenac Induces Apoptosis in Acute Myeloid Leukemia Cells.
Kathrin Renner, Anton Seilbeck, +14 authors, Marina Kreutz.
Front Pharmacol, 2018 Nov 20; 9. PMID: 30450049    Free PMC article.
Exercise inhibits tumor growth and central carbon metabolism in patient-derived xenograft models of colorectal cancer.
Min Lu, Sydney M Sanderson, +5 authors, David S Hsu.
Cancer Metab, 2018 Nov 27; 6. PMID: 30473788    Free PMC article.
Probing carbohydrate metabolism using hyperpolarized 13 C-labeled molecules.
Jaspal Singh, Eul Hyun Suh, +3 authors, Zoltan Kovacs.
NMR Biomed, 2018 Nov 27; 32(10). PMID: 30474153    Free PMC article.
Review.
Critical role of AMPK in redox regulation under glucose starvation.
Yi Ren, Han-Ming Shen.
Redox Biol, 2019 Mar 12; 25. PMID: 30853530    Free PMC article.
Review.
Insulin Receptor Isoform A Modulates Metabolic Reprogramming of Breast Cancer Cells in Response to IGF2 and Insulin Stimulation.
Veronica Vella, Maria Luisa Nicolosi, +3 authors, Antonino Belfiore.
Cells, 2019 Sep 05; 8(9). PMID: 31480557    Free PMC article.
Tracking Photodynamic- and Chemotherapy-Induced Redox-State Perturbations in 3D Culture Models of Pancreatic Cancer: A Tool for Identifying Therapy-Induced Metabolic Changes.
Mans Broekgaarden, Anne-Laure Bulin, +2 authors, Tayyaba Hasan.
J Clin Med, 2019 Sep 11; 8(9). PMID: 31500115    Free PMC article.
Neural stem cell temporal patterning and brain tumour growth rely on oxidative phosphorylation.
Jelle van den Ameele, Andrea H Brand.
Elife, 2019 Sep 13; 8. PMID: 31513013    Free PMC article.
SLC1A3 contributes to L-asparaginase resistance in solid tumors.
Jianhui Sun, Remco Nagel, +12 authors, Reuven Agami.
EMBO J, 2019 Sep 17; 38(21). PMID: 31523835    Free PMC article.
Diverse Roads Taken by 13C-Glucose-Derived Metabolites in Breast Cancer Cells Exposed to Limiting Glucose and Glutamine Conditions.
Maria Gkiouli, Philipp Biechl, Wolfgang Eisenreich, Angela M Otto.
Cells, 2019 Sep 25; 8(10). PMID: 31547005    Free PMC article.
Effect of glutaminase inhibition on cancer-induced bone pain.
Jennifer Fazzari, Gurmit Singh.
Breast Cancer (Dove Med Press), 2019 Oct 02; 11. PMID: 31571981    Free PMC article.
Loss of thymidine kinase 1 inhibits lung cancer growth and metastatic attributes by reducing GDF15 expression.
Parmanand Malvi, Radoslav Janostiak, +2 authors, Narendra Wajapeyee.
PLoS Genet, 2019 Oct 08; 15(10). PMID: 31589613    Free PMC article.
Elevated Endogenous SDHA Drives Pathological Metabolism in Highly Metastatic Uveal Melanoma.
Chandrani Chattopadhyay, Junna Oba, +9 authors, Scott E Woodman.
Invest Ophthalmol Vis Sci, 2019 Oct 10; 60(13). PMID: 31596927    Free PMC article.
Cellular redox state constrains serine synthesis and nucleotide production to impact cell proliferation.
Frances F Diehl, Caroline A Lewis, Brian P Fiske, Matthew G Vander Heiden.
Nat Metab, 2019 Oct 11; 1(9). PMID: 31598584    Free PMC article.
RORγ is a targetable master regulator of cholesterol biosynthesis in a cancer subtype.
Demin Cai, Junjian Wang, +19 authors, Hong-Wu Chen.
Nat Commun, 2019 Oct 13; 10(1). PMID: 31604910    Free PMC article.
The Many Facets of Tumor Heterogeneity: Is Metabolism Lagging Behind?
Sara Loponte, Sara Lovisa, +2 authors, Andrea Viale.
Cancers (Basel), 2019 Oct 19; 11(10). PMID: 31623133    Free PMC article.
Review.
Amino acids signatures of distance-related surgical margins of oral squamous cell carcinoma.
Xi-Hu Yang, Xiao-Xin Zhang, +8 authors, Qin-Gang Hu.
EBioMedicine, 2019 Oct 22; 48. PMID: 31631041    Free PMC article.
The natural compound gracillin exerts potent antitumor activity by targeting mitochondrial complex II.
Hye-Young Min, Hyun-Ji Jang, +6 authors, Ho-Young Lee.
Cell Death Dis, 2019 Oct 28; 10(11). PMID: 31649278    Free PMC article.
Nuclear glycogenolysis modulates histone acetylation: a novel mechanism of epigenetic regulation in cancer.
Xifeng Dong.
Cancer Commun (Lond), 2019 Nov 11; 39(1). PMID: 31706347    Free PMC article.
The immunoregulatory protein B7-H3 promotes aerobic glycolysis in oral squamous carcinoma via PI3K/Akt/mTOR pathway.
Zhangao Li, Jiyuan Liu, Lin Que, Xiufa Tang.
J Cancer, 2019 Nov 19; 10(23). PMID: 31737114    Free PMC article.
The Interplay Between the Genetic and Immune Landscapes of AML: Mechanisms and Implications for Risk Stratification and Therapy.
Lourdes M Mendez, Ryan R Posey, Pier Paolo Pandolfi.
Front Oncol, 2019 Nov 30; 9. PMID: 31781488    Free PMC article.
Review.
A high-throughput screen identifies that CDK7 activates glucose consumption in lung cancer cells.
Chiara Ghezzi, Alicia Wong, +3 authors, Peter M Clark.
Nat Commun, 2019 Dec 01; 10(1). PMID: 31784510    Free PMC article.
An open-space microfluidic chip with fluid walls for online detection of VEGF via rolling circle amplification.
Shuo Feng, Sifeng Mao, +3 authors, Jin-Ming Lin.
Chem Sci, 2019 Dec 06; 10(37). PMID: 31803431    Free PMC article.
Strategies For Targeting Chronic Myeloid Leukaemia Stem Cells.
Giovanna Carrà, Antonio Cartellà, Beatrice Maffeo, Alessandro Morotti.
Blood Lymphat Cancer, 2019 Dec 07; 9. PMID: 31807112    Free PMC article.
Review.
Identification of Transcriptional Metabolic Dysregulation in Subtypes of Pituitary Adenoma by Integrated Bioinformatics Analysis.
Jintao Hu, Huachun Yin, Bo Li, Hui Yang.
Diabetes Metab Syndr Obes, 2019 Dec 11; 12. PMID: 31819570    Free PMC article.
The second genome: Effects of the mitochondrial genome on cancer progression.
Adam D Scheid, Thomas C Beadnell, Danny R Welch.
Adv Cancer Res, 2019 Mar 20; 142. PMID: 30885364    Free PMC article.
Mitochondrial fission regulator 2 (MTFR2) promotes growth, migration, invasion and tumour progression in breast cancer cells.
Guanming Lu, Yuanhui Lai, +7 authors, Jie Li.
Aging (Albany NY), 2019 Nov 20; 11(22). PMID: 31740625    Free PMC article.
mTORC2 links growth factor signaling with epigenetic regulation of iron metabolism in glioblastoma.
Kenta Masui, Mio Harachi, +11 authors, Noriyuki Shibata.
J Biol Chem, 2019 Nov 13; 294(51). PMID: 31712311    Free PMC article.
Metabolic heterogeneity confers differences in melanoma metastatic potential.
Alpaslan Tasdogan, Brandon Faubert, +14 authors, Sean J Morrison.
Nature, 2019 Dec 20; 577(7788). PMID: 31853067    Free PMC article.
Highly Cited.
Cell Death Response to DNA Damage.
Jean Y J Wang.
Yale J Biol Med, 2019 Dec 24; 92(4). PMID: 31866794    Free PMC article.
Review.
Toward a better understanding of folate metabolism in health and disease.
Yuxiang Zheng, Lewis C Cantley.
J Exp Med, 2018 Dec 28; 216(2). PMID: 30587505    Free PMC article.
Review.
Modulation of redox metabolism negates cancer-associated fibroblasts-induced treatment resistance in a heterotypic 3D culture platform of pancreatic cancer.
Mans Broekgaarden, Sriram Anbil, +5 authors, Tayyaba Hasan.
Biomaterials, 2019 Sep 09; 222. PMID: 31494503    Free PMC article.
A systematic flux analysis approach to identify metabolic vulnerabilities in human breast cancer cell lines.
Sheree D Martin, Sean L McGee.
Cancer Metab, 2020 Jan 01; 7. PMID: 31890204    Free PMC article.
Liver-Type Glutaminase GLS2 Is a Druggable Metabolic Node in Luminal-Subtype Breast Cancer.
Michael J Lukey, Ahmad A Cluntun, +9 authors, Richard A Cerione.
Cell Rep, 2019 Oct 03; 29(1). PMID: 31577957    Free PMC article.
Rewiring of Cancer Cell Metabolism by Mitochondrial VDAC1 Depletion Results in Time-Dependent Tumor Reprogramming: Glioblastoma as a Proof of Concept.
Tasleem Arif, Oriel Stern, +2 authors, Varda Shoshan-Barmatz.
Cells, 2019 Oct 31; 8(11). PMID: 31661894    Free PMC article.
Tissue of origin dictates GOT1 dependence and confers synthetic lethality to radiotherapy.
Barbara S Nelson, Lin Lin, +23 authors, Costas A Lyssiotis.
Cancer Metab, 2020 Jan 08; 8. PMID: 31908776    Free PMC article.
Fructose-1,6-Bisphosphatase 2 Inhibits Sarcoma Progression by Restraining Mitochondrial Biogenesis.
Peiwei Huangyang, Fuming Li, +7 authors, M Celeste Simon.
Cell Metab, 2019 Nov 26; 31(1). PMID: 31761563    Free PMC article.
O-GlcNAcylation of PGK1 coordinates glycolysis and TCA cycle to promote tumor growth.
Hao Nie, Haixing Ju, +6 authors, Wen Yi.
Nat Commun, 2020 Jan 09; 11(1). PMID: 31911580    Free PMC article.
MicroRNAs in Tumor Cell Metabolism: Roles and Therapeutic Opportunities.
Abraham Pedroza-Torres, Sandra L Romero-Córdoba, +9 authors, Luis A Herrera.
Front Oncol, 2020 Jan 11; 9. PMID: 31921661    Free PMC article.
Review.
Multiple Layers of Phospho-Regulation Coordinate Metabolism and the Cell Cycle in Budding Yeast.
Lichao Zhang, Sebastian Winkler, +4 authors, Jennifer C Ewald.
Front Cell Dev Biol, 2020 Jan 11; 7. PMID: 31921850    Free PMC article.
ASCT2 (SLC1A5)-dependent glutamine uptake is involved in the progression of head and neck squamous cell carcinoma.
Ze Zhang, Ruoyan Liu, +4 authors, Jingtao Luo.
Br J Cancer, 2019 Dec 11; 122(1). PMID: 31819178    Free PMC article.
Phospholipids are A Potentially Important Source of Tissue Biomarkers for Hepatocellular Carcinoma: Results of a Pilot Study Involving Targeted Metabolomics.
Erin B Evangelista, Sandi A Kwee, +5 authors, Linda L Wong.
Diagnostics (Basel), 2019 Nov 02; 9(4). PMID: 31671805    Free PMC article.
Compartment and hub definitions tune metabolic networks for metabolomic interpretations.
T Cameron Waller, Jordan A Berg, +2 authors, Jared Rutter.
Gigascience, 2020 Jan 24; 9(1). PMID: 31972021    Free PMC article.
Impaired lipid biosynthesis hinders anti-tumor efficacy of intratumoral iNKT cells.
Sicheng Fu, Kaixin He, +18 authors, Li Bai.
Nat Commun, 2020 Jan 25; 11(1). PMID: 31974378    Free PMC article.
The mitochondrial HSP90 paralog TRAP1 forms an OXPHOS-regulated tetramer and is involved in mitochondrial metabolic homeostasis.
Abhinav Joshi, Li Dai, +11 authors, Didier Picard.
BMC Biol, 2020 Jan 29; 18(1). PMID: 31987035    Free PMC article.
The Rise of Physiologic Media.
Jason R Cantor.
Trends Cell Biol, 2019 Oct 19; 29(11). PMID: 31623927    Free PMC article.
Review.
Activation of Oxidative Stress Response in Cancer Generates a Druggable Dependency on Exogenous Non-essential Amino Acids.
Sarah E LeBoeuf, Warren L Wu, +7 authors, Thales Papagiannakopoulos.
Cell Metab, 2019 Dec 10; 31(2). PMID: 31813821    Free PMC article.
Regulation of Tumor Initiation by the Mitochondrial Pyruvate Carrier.
Claire L Bensard, Dona R Wisidagama, +22 authors, Jared Rutter.
Cell Metab, 2019 Dec 10; 31(2). PMID: 31813825    Free PMC article.
Dynamic 13C Flux Analysis Captures the Reorganization of Adipocyte Glucose Metabolism in Response to Insulin.
Lake-Ee Quek, James R Krycer, +13 authors, Shinya Kuroda.
iScience, 2020 Feb 15; 23(2). PMID: 32058966    Free PMC article.
Immunometabolism at the interface between macrophages and pathogens.
David G Russell, Lu Huang, Brian C VanderVen.
Nat Rev Immunol, 2019 Jan 27; 19(5). PMID: 30679807    Free PMC article.
Highly Cited. Review.
CHCHD4 regulates tumour proliferation and EMT-related phenotypes, through respiratory chain-mediated metabolism.
Luke W Thomas, Cinzia Esposito, +5 authors, Margaret Ashcroft.
Cancer Metab, 2019 Jul 28; 7. PMID: 31346464    Free PMC article.
Comprehensive analysis of the association between tumor glycolysis and immune/inflammation function in breast cancer.
Wenhui Li, Ming Xu, +7 authors, Pengfei Yi.
J Transl Med, 2020 Feb 20; 18(1). PMID: 32070368    Free PMC article.
Increased Serine Synthesis Provides an Advantage for Tumors Arising in Tissues Where Serine Levels Are Limiting.
Mark R Sullivan, Katherine R Mattaini, +9 authors, Matthew G Vander Heiden.
Cell Metab, 2019 Mar 25; 29(6). PMID: 30905671    Free PMC article.
Highly Cited.
EGFR-Pak Signaling Selectively Regulates Glutamine Deprivation-Induced Macropinocytosis.
Szu-Wei Lee, Yijuan Zhang, +3 authors, Cosimo Commisso.
Dev Cell, 2019 Jul 02; 50(3). PMID: 31257175    Free PMC article.
The complexity of the serine glycine one-carbon pathway in cancer.
Miguel Reina-Campos, Maria T Diaz-Meco, Jorge Moscat.
J Cell Biol, 2019 Nov 07; 219(1). PMID: 31690618    Free PMC article.
Review.
p63 and SOX2 Dictate Glucose Reliance and Metabolic Vulnerabilities in Squamous Cell Carcinomas.
Meng-Hsiung Hsieh, Joshua H Choe, +28 authors, Jung-Whan Kim.
Cell Rep, 2019 Aug 15; 28(7). PMID: 31412252    Free PMC article.
TCA Cycle Rewiring as Emerging Metabolic Signature of Hepatocellular Carcinoma.
Simona Todisco, Paolo Convertini, Vito Iacobazzi, Vittoria Infantino.
Cancers (Basel), 2019 Dec 29; 12(1). PMID: 31881713    Free PMC article.
Review.
Metabolic Reprogramming and Vulnerabilities in Cancer.
Costas A Lyssiotis, Deepak Nagrath.
Cancers (Basel), 2020 Jan 08; 12(1). PMID: 31905922    Free PMC article.
Survival-Associated Metabolic Genes in Human Papillomavirus-Positive Head and Neck Cancers.
Martin A Prusinkiewicz, Steven F Gameiro, +6 authors, Joe S Mymryk.
Cancers (Basel), 2020 Jan 24; 12(1). PMID: 31968678    Free PMC article.
Dihydropyrimidinase protects from DNA replication stress caused by cytotoxic metabolites.
Jihane Basbous, Antoine Aze, +11 authors, Angelos Constantinou.
Nucleic Acids Res, 2019 Dec 20; 48(4). PMID: 31853544    Free PMC article.
Macropinocytosis confers resistance to therapies targeting cancer anabolism.
Vaishali Jayashankar, Aimee L Edinger.
Nat Commun, 2020 Mar 01; 11(1). PMID: 32111826    Free PMC article.
Inhibition of ERRα Prevents Mitochondrial Pyruvate Uptake Exposing NADPH-Generating Pathways as Targetable Vulnerabilities in Breast Cancer.
Sunghee Park, Rachid Safi, +6 authors, Donald P McDonnell.
Cell Rep, 2019 Jun 20; 27(12). PMID: 31216477    Free PMC article.
SREBP1-dependent de novo fatty acid synthesis gene expression is elevated in malignant melanoma and represents a cellular survival trait.
Su Wu, Anders M Näär.
Sci Rep, 2019 Jul 19; 9(1). PMID: 31316083    Free PMC article.
Drp1 Promotes KRas-Driven Metabolic Changes to Drive Pancreatic Tumor Growth.
Sarbajeet Nagdas, Jennifer A Kashatus, +9 authors, David F Kashatus.
Cell Rep, 2019 Aug 15; 28(7). PMID: 31412251    Free PMC article.
Evaluating Cell Metabolism Through Autofluorescence Imaging of NAD(P)H and FAD.
Olivia I Kolenc, Kyle P Quinn.
Antioxid Redox Signal, 2017 Dec 23; 30(6). PMID: 29268621    Free PMC article.
Review.
Eco-evolutionary causes and consequences of temporal changes in intratumoural blood flow.
Robert J Gillies, Joel S Brown, Alexander R A Anderson, Robert A Gatenby.
Nat Rev Cancer, 2018 Jun 13; 18(9). PMID: 29891961    Free PMC article.
Highly Cited. Review.
Cytosolic Aspartate Availability Determines Cell Survival When Glutamine Is Limiting.
H Furkan Alkan, Katharina E Walter, +11 authors, Juliane G Bogner-Strauss.
Cell Metab, 2018 Aug 21; 28(5). PMID: 30122555    Free PMC article.
Highly Cited.
PML-Regulated Mitochondrial Metabolism Enhances Chemosensitivity in Human Ovarian Cancers.
Géraldine Gentric, Yann Kieffer, +15 authors, Fatima Mechta-Grigoriou.
Cell Metab, 2018 Sep 25; 29(1). PMID: 30244973    Free PMC article.
Tumor-Stroma Mechanics Coordinate Amino Acid Availability to Sustain Tumor Growth and Malignancy.
Thomas Bertero, William M Oldham, +12 authors, Cedric Gaggioli.
Cell Metab, 2018 Oct 09; 29(1). PMID: 30293773    Free PMC article.
Highly Cited.
Real-Time Imaging of Mitochondrial ATP Dynamics Reveals the Metabolic Setting of Single Cells.
Maria R Depaoli, Felix Karsten, +8 authors, Roland Malli.
Cell Rep, 2018 Oct 12; 25(2). PMID: 30304688    Free PMC article.
Autophagy and Hallmarks of Cancer.
Tianzhi Huang, Xiao Song, +6 authors, Shi-Yuan Cheng.
Crit Rev Oncog, 2018 Oct 13; 23(5-6). PMID: 30311559    Free PMC article.
Review.
Assessment of Tumor Redox Status through (S)-4-(3-[18F]fluoropropyl)-L-Glutamic Acid PET Imaging of System xc - Activity.
Patrick N McCormick, Hannah E Greenwood, +14 authors, Timothy H Witney.
Cancer Res, 2018 Nov 08; 79(4). PMID: 30401715    Free PMC article.
Hyperactivity of the transcription factor Nrf2 causes metabolic reprogramming in mouse esophagus.
Junsheng Fu, Zhaohui Xiong, +8 authors, Xiaoxin Chen.
J Biol Chem, 2018 Nov 10; 294(1). PMID: 30409900    Free PMC article.
Targeting intermediary metabolism enhances the efficacy of BH3 mimetic therapy in hematologic malignancies.
Aoula Al-Zebeeby, Meike Vogler, +6 authors, Shankar Varadarajan.
Haematologica, 2018 Nov 24; 104(5). PMID: 30467206    Free PMC article.
An integrative theory for cancer (Review).
Guopei Luo, Na Liu.
Int J Mol Med, 2018 Nov 30; 43(2). PMID: 30483756    Free PMC article.
Review.
Toll-like receptor 2 regulates metabolic reprogramming in gastric cancer via superoxide dismutase 2.
You Dong Liu, Liang Yu, +10 authors, Ji Kun Li.
Int J Cancer, 2018 Dec 12; 144(12). PMID: 30536754    Free PMC article.
Mutant p53 as a guardian of the cancer cell.
Fiamma Mantovani, Licio Collavin, Giannino Del Sal.
Cell Death Differ, 2018 Dec 13; 26(2). PMID: 30538286    Free PMC article.
Highly Cited. Review.
Pan-cancer analysis of transcriptional metabolic dysregulation using The Cancer Genome Atlas.
S R Rosario, M D Long, +3 authors, D J Smiraglia.
Nat Commun, 2018 Dec 16; 9(1). PMID: 30552315    Free PMC article.
Highly Cited.
Spatially resolved metabolomics to discover tumor-associated metabolic alterations.
Chenglong Sun, Tiegang Li, +15 authors, Zeper Abliz.
Proc Natl Acad Sci U S A, 2018 Dec 19; 116(1). PMID: 30559182    Free PMC article.
Imaging Metabolic Processes to Predict Radiation Responses.
Sarwat Naz, Shun Kishimoto, James B Mitchell, Murali C Krishna.
Semin Radiat Oncol, 2018 Dec 24; 29(1). PMID: 30573188    Free PMC article.
Review.
Depletion of dAKAP1-protein kinase A signaling islands from the outer mitochondrial membrane alters breast cancer cell metabolism and motility.
Stacey Aggarwal, Laura Gabrovsek, +4 authors, John D Scott.
J Biol Chem, 2019 Jan 02; 294(9). PMID: 30598507    Free PMC article.
The coordinated action of VCP/p97 and GCN2 regulates cancer cell metabolism and proteostasis during nutrient limitation.
Katarzyna Parzych, Paula Saavedra-García, +16 authors, Holger W Auner.
Oncogene, 2019 Jan 11; 38(17). PMID: 30626938    Free PMC article.
HPV, tumour metabolism and novel target identification in head and neck squamous cell carcinoma.
Jason C Fleming, Jeongmin Woo, +13 authors, Gareth J Thomas.
Br J Cancer, 2019 Jan 19; 120(3). PMID: 30655616    Free PMC article.
Inhibiting neddylation modification alters mitochondrial morphology and reprograms energy metabolism in cancer cells.
Qiyin Zhou, Hua Li, +9 authors, Yi Sun.
JCI Insight, 2019 Jan 23; 4(4). PMID: 30668548    Free PMC article.
Targeting acidity in cancer and diabetes.
Robert J Gillies, Christian Pilot, Yoshinori Marunaka, Stefano Fais.
Biochim Biophys Acta Rev Cancer, 2019 Feb 02; 1871(2). PMID: 30708040    Free PMC article.
Review.
A Genome-wide Haploid Genetic Screen Identifies Regulators of Glutathione Abundance and Ferroptosis Sensitivity.
Jennifer Yinuo Cao, Aunoy Poddar, +10 authors, Scott J Dixon.
Cell Rep, 2019 Feb 07; 26(6). PMID: 30726737    Free PMC article.
Highly Cited.
Brivanib in combination with Notch3 silencing shows potent activity in tumour models.
Catia Giovannini, Anna Maria Salzano, +9 authors, Laura Gramantieri.
Br J Cancer, 2019 Feb 16; 120(6). PMID: 30765875    Free PMC article.
MiR-135 suppresses glycolysis and promotes pancreatic cancer cell adaptation to metabolic stress by targeting phosphofructokinase-1.
Ying Yang, Mari B Ishak Gabra, +9 authors, Mei Kong.
Nat Commun, 2019 Feb 20; 10(1). PMID: 30778058    Free PMC article.
Highly Cited.
Kindlin-2 links mechano-environment to proline synthesis and tumor growth.
Ling Guo, Chunhong Cui, +9 authors, Chuanyue Wu.
Nat Commun, 2019 Feb 21; 10(1). PMID: 30783087    Free PMC article.
ROS and Oxidative Stress Are Elevated in Mitosis during Asynchronous Cell Cycle Progression and Are Exacerbated by Mitotic Arrest.
Jesse C Patterson, Brian A Joughin, +3 authors, Michael B Yaffe.
Cell Syst, 2019 Feb 25; 8(2). PMID: 30797774    Free PMC article.
Gboxin is an oxidative phosphorylation inhibitor that targets glioblastoma.
Yufeng Shi, S Kyun Lim, +11 authors, Luis F Parada.
Nature, 2019 Mar 08; 567(7748). PMID: 30842654    Free PMC article.
Highly Cited.
Effective breast cancer combination therapy targeting BACH1 and mitochondrial metabolism.
Jiyoung Lee, Ali E Yesilkanal, +16 authors, Marsha Rich Rosner.
Nature, 2019 Mar 08; 568(7751). PMID: 30842661    Free PMC article.
Highly Cited.
SOX12 promotes colorectal cancer cell proliferation and metastasis by regulating asparagine synthesis.
Feng Du, Jie Chen, +10 authors, Limin Xia.
Cell Death Dis, 2019 Mar 13; 10(3). PMID: 30858360    Free PMC article.
PKM2 coordinates glycolysis with mitochondrial fusion and oxidative phosphorylation.
Tong Li, Jinbo Han, +3 authors, Yiguo Wang.
Protein Cell, 2019 Mar 20; 10(8). PMID: 30887444    Free PMC article.
A GPX4-dependent cancer cell state underlies the clear-cell morphology and confers sensitivity to ferroptosis.
Yilong Zou, Michael J Palte, +17 authors, Stuart L Schreiber.
Nat Commun, 2019 Apr 10; 10(1). PMID: 30962421    Free PMC article.
Highly Cited.
Genetic variants in the liver kinase B1-AMP-activated protein kinase pathway genes and pancreatic cancer risk.
Xinyuan Xu, Danwen Qian, +6 authors, Qingyi Wei.
Mol Carcinog, 2019 Apr 19; 58(8). PMID: 30997723    Free PMC article.
Nf1 loss promotes Kras-driven lung adenocarcinoma and results in Psat1-mediated glutamate dependence.
Xiaojing Wang, Shengping Min, +10 authors, Yuqing Chen.
EMBO Mol Med, 2019 May 01; 11(6). PMID: 31036704    Free PMC article.
Spectral tracing of deuterium for imaging glucose metabolism.
Luyuan Zhang, Lingyan Shi, +5 authors, Wei Min.
Nat Biomed Eng, 2019 May 01; 3(5). PMID: 31036888    Free PMC article.
A White-Box Machine Learning Approach for Revealing Antibiotic Mechanisms of Action.
Jason H Yang, Sarah N Wright, +9 authors, James J Collins.
Cell, 2019 May 14; 177(6). PMID: 31080069    Free PMC article.
Highly Cited.
Mitophagy in Cancer: A Tale of Adaptation.
Monica Vara-Perez, Blanca Felipe-Abrio, Patrizia Agostinis.
Cells, 2019 May 28; 8(5). PMID: 31121959    Free PMC article.
Review.
Cancer-associated mutation and beyond: The emerging biology of isocitrate dehydrogenases in human disease.
Serena Tommasini-Ghelfi, Kevin Murnan, +3 authors, Alexander H Stegh.
Sci Adv, 2019 May 28; 5(5). PMID: 31131326    Free PMC article.
Review.
High OGT activity is essential for MYC-driven proliferation of prostate cancer cells.
Harri M Itkonen, Alfonso Urbanucci, +5 authors, Ian G Mills.
Theranostics, 2019 Jun 01; 9(8). PMID: 31149037    Free PMC article.
mTOR Senses Intracellular pH through Lysosome Dispersion from RHEB.
Zandra E Walton, Rebekah C Brooks, Chi V Dang.
Bioessays, 2019 Jun 04; 41(7). PMID: 31157925    Free PMC article.
Role of tumor and host autophagy in cancer metabolism.
Laura Poillet-Perez, Eileen White.
Genes Dev, 2019 Jun 05; 33(11-12). PMID: 31160394    Free PMC article.
Highly Cited. Review.
Determinants of nutrient limitation in cancer.
Mark R Sullivan, Matthew G Vander Heiden.
Crit Rev Biochem Mol Biol, 2019 Jun 05; 54(3). PMID: 31162937    Free PMC article.
Review.
Identification of metabolic vulnerabilities of receptor tyrosine kinases-driven cancer.
Nan Jin, Aiwei Bi, +20 authors, Min Huang.
Nat Commun, 2019 Jun 22; 10(1). PMID: 31221965    Free PMC article.
Studying metabolic flux adaptations in cancer through integrated experimental-computational approaches.
Shoval Lagziel, Won Dong Lee, Tomer Shlomi.
BMC Biol, 2019 Jul 06; 17(1). PMID: 31272436    Free PMC article.
Review.
Exploiting metabolic vulnerabilities for personalized therapy in acute myeloid leukemia.
Lucille Stuani, Marie Sabatier, Jean-Emmanuel Sarry.
BMC Biol, 2019 Jul 20; 17(1). PMID: 31319822    Free PMC article.
Review.
Metabolic Dysregulations and Epigenetics: A Bidirectional Interplay that Drives Tumor Progression.
Fabiana Crispo, Valentina Condelli, +5 authors, Matteo Landriscina.
Cells, 2019 Aug 02; 8(8). PMID: 31366176    Free PMC article.
Review.
Imaging of glucose metabolism by 13C-MRI distinguishes pancreatic cancer subtypes in mice.
Shun Kishimoto, Jeffrey R Brender, +17 authors, Murali C Krishna.
Elife, 2019 Aug 14; 8. PMID: 31408004    Free PMC article.
Metabolic landscape of the tumor microenvironment at single cell resolution.
Zhengtao Xiao, Ziwei Dai, Jason W Locasale.
Nat Commun, 2019 Aug 23; 10(1). PMID: 31434891    Free PMC article.
Promoter demethylation of the asparagine synthetase gene is required for ATF4-dependent adaptation to asparagine depletion.
Jie Jiang, Sankalp Srivastava, +10 authors, Ji Zhang.
J Biol Chem, 2019 Oct 30; 294(49). PMID: 31659118    Free PMC article.
Reactive metabolite production is a targetable liability of glycolytic metabolism in lung cancer.
Alba Luengo, Keene L Abbott, +10 authors, Matthew G Vander Heiden.
Nat Commun, 2019 Dec 08; 10(1). PMID: 31811141    Free PMC article.
The molecular rationale for therapeutic targeting of glutamine metabolism in pulmonary hypertension.
Thomas Bertero, Dror Perk, Stephen Y Chan.
Expert Opin Ther Targets, 2019 May 06; 23(6). PMID: 31055988    Free PMC article.
Review.
The Tumor Metabolic Microenvironment: Lessons from Lactate.
Juan C García-Cañaveras, Li Chen, Joshua D Rabinowitz.
Cancer Res, 2019 Jun 07; 79(13). PMID: 31171526    Free PMC article.
Highly Cited. Review.
Metabolites in a mouse cancer model enhance venous thrombogenicity through the aryl hydrocarbon receptor-tissue factor axis.
Mostafa Belghasem, Daniel Roth, +13 authors, Vipul C Chitalia.
Blood, 2019 Dec 27; 134(26). PMID: 31877217    Free PMC article.
The Pentose Phosphate Pathway and Its Involvement in Cisplatin Resistance.
Isabella Giacomini, Eugenio Ragazzi, Gianfranco Pasut, Monica Montopoli.
Int J Mol Sci, 2020 Feb 07; 21(3). PMID: 32023830    Free PMC article.
Review.
How to starve cancer cells when nutrients are abundant.
Hamidullah Khan, Stefan M Schieke.
Mol Cell Oncol, 2020 Mar 12; 7(2). PMID: 32158929    Free PMC article.
SLC25A32 sustains cancer cell proliferation by regulating flavin adenine nucleotide (FAD) metabolism.
Valeria Santoro, Ilya Kovalenko, +5 authors, Sven Christian.
Oncotarget, 2020 Mar 14; 11(8). PMID: 32166001    Free PMC article.
Cancer associated fibroblast FAK regulates malignant cell metabolism.
Fevzi Demircioglu, Jun Wang, +22 authors, Kairbaan Hodivala-Dilke.
Nat Commun, 2020 Mar 12; 11(1). PMID: 32157087    Free PMC article.
Antioxidant-Conjugated Peptide Attenuated Metabolic Reprogramming in Pulmonary Hypertension.
Mathews Valuparampil Varghese, Maki Niihori, +4 authors, Ruslan Rafikov.
Antioxidants (Basel), 2020 Jan 30; 9(2). PMID: 31991719    Free PMC article.
Inhibition of Anaplerosis Attenuated Vascular Proliferation in Pulmonary Arterial Hypertension.
Mathews Valuparampil Varghese, Joel James, +3 authors, Ruslan Rafikov.
J Clin Med, 2020 Feb 12; 9(2). PMID: 32041182    Free PMC article.
A shift in glutamine nitrogen metabolism contributes to the malignant progression of cancer.
Manabu Kodama, Kiyotaka Oshikawa, +8 authors, Keiichi I Nakayama.
Nat Commun, 2020 Mar 19; 11(1). PMID: 32184390    Free PMC article.
Emerging Roles for Branched-Chain Amino Acid Metabolism in Cancer.
Sharanya Sivanand, Matthew G Vander Heiden.
Cancer Cell, 2020 Feb 13; 37(2). PMID: 32049045    Free PMC article.
Review.
Regulatory Role of Hexokinase 2 in Modulating Head and Neck Tumorigenesis.
Wan-Chun Li, Chien-Hsiang Huang, +8 authors, Kuo-Wei Chang.
Front Oncol, 2020 Mar 21; 10. PMID: 32195170    Free PMC article.
The PHGDH enigma: Do cancer cells only need serine or also a redox modulator?
Albert M Li, Jiangbin Ye.
Cancer Lett, 2020 Feb 08; 476. PMID: 32032680    Free PMC article.
Codependency of Metabolism and Epigenetics Drives Cancer Progression: A Review.
Kenta Masui, Mio Harachi, +2 authors, Noriyuki Shibata.
Acta Histochem Cytochem, 2020 Mar 24; 53(1). PMID: 32201436    Free PMC article.
Review.
Metabolic Plasticity in Chemotherapy Resistance.
Maria Andrea Desbats, Isabella Giacomini, Tommaso Prayer-Galetti, Monica Montopoli.
Front Oncol, 2020 Mar 27; 10. PMID: 32211323    Free PMC article.
Review.
Glucose Metabolism on Tumor Plasticity, Diagnosis, and Treatment.
Xiaoping Lin, Zizheng Xiao, +2 authors, Huiqin Guo.
Front Oncol, 2020 Mar 27; 10. PMID: 32211335    Free PMC article.
Review.
GLUT5-mediated fructose utilization drives lung cancer growth by stimulating fatty acid synthesis and AMPK/mTORC1 signaling.
Wen-Lian Chen, Xing Jin, +15 authors, Lijun Jia.
JCI Insight, 2020 Feb 14; 5(3). PMID: 32051337    Free PMC article.
O-GlcNAc Transferase Regulates Cancer Stem-like Potential of Breast Cancer Cells.
Neha M Akella, Giang Le Minh, +5 authors, Mauricio J Reginato.
Mol Cancer Res, 2020 Jan 25; 18(4). PMID: 31974291    Free PMC article.
Therapeutic strategies for diffuse midline glioma from high-throughput combination drug screening.
Grant L Lin, Kelli M Wilson, +30 authors, Michelle Monje.
Sci Transl Med, 2019 Nov 22; 11(519). PMID: 31748226    Free PMC article.
NAD metabolic dependency in cancer is shaped by gene amplification and enhancer remodelling.
Sudhir Chowdhry, Ciro Zanca, +12 authors, Paul S Mischel.
Nature, 2019 Apr 26; 569(7757). PMID: 31019297    Free PMC article.
Highly Cited.
Proteomics Analysis Reveals that Warburg Effect along with Modification in Lipid Metabolism Improves In Vitro Embryo Development under Low Oxygen.
Qaisar Shahzad, Liping Pu, +6 authors, Yangqing Lu.
Int J Mol Sci, 2020 Mar 19; 21(6). PMID: 32183390    Free PMC article.
Immune cell metabolism in autoimmunity.
X Teng, W Li, C Cornaby, L Morel.
Clin Exp Immunol, 2019 Feb 17; 197(2). PMID: 30770544    Free PMC article.
Review.
VISAGE Reveals a Targetable Mitotic Spindle Vulnerability in Cancer Cells.
Jesse C Patterson, Brian A Joughin, +9 authors, Michael B Yaffe.
Cell Syst, 2019 Jul 16; 9(1). PMID: 31302152    Free PMC article.
Celiac disease-associated Neisseria flavescens decreases mitochondrial respiration in CaCo-2 epithelial cells: Impact of Lactobacillus paracasei CBA L74 on bacterial-induced cellular imbalance.
Giuseppe Labruna, Merlin Nanayakkara, +9 authors, Lucia Sacchetti.
Cell Microbiol, 2019 May 02; 21(8). PMID: 31042331    Free PMC article.
Effect of IDH3a on glucose uptake in lung adenocarcinoma: A pilot study based on [18 F]FDG.
Bulin Du, Tong Sun, +2 authors, Yaming Li.
Cancer Med, 2019 Jul 30; 8(11). PMID: 31355526    Free PMC article.
Uncovering the Underlying Mechanisms of Cancer Metabolism through the Landscapes and Probability Flux Quantifications.
Wenbo Li, Jin Wang.
iScience, 2020 Apr 11; 23(4). PMID: 32276228    Free PMC article.
Role of Glucose Metabolism Reprogramming in the Pathogenesis of Cholangiocarcinoma.
Kishor Pant, Seth Richard, Estanislao Peixoto, Sergio A Gradilone.
Front Med (Lausanne), 2020 Apr 23; 7. PMID: 32318579    Free PMC article.
Review.
Metabolic determinants of lupus pathogenesis.
Xiangyu Teng, Josephine Brown, +2 authors, Laurence Morel.
Immunol Rev, 2020 Mar 13; 295(1). PMID: 32162304    Free PMC article.
Review.
Severe metabolic alterations in liver cancer lead to ERK pathway activation and drug resistance.
Zeribe Chike Nwosu, Weronika Piorońska, +23 authors, Steven Dooley.
EBioMedicine, 2020 Apr 25; 54. PMID: 32330875    Free PMC article.
Cancer Cells Tune the Signaling Pathways to Empower de Novo Synthesis of Nucleotides.
Elodie Villa, Eunus S Ali, Umakant Sahu, Issam Ben-Sahra.
Cancers (Basel), 2019 May 22; 11(5). PMID: 31108873    Free PMC article.
Review.
miR-27a is a master regulator of metabolic reprogramming and chemoresistance in colorectal cancer.
Giovannina Barisciano, Tommaso Colangelo, +16 authors, Lina Sabatino.
Br J Cancer, 2020 Mar 07; 122(9). PMID: 32132656    Free PMC article.
UCP2 Deficiency Increases Colon Tumorigenesis by Promoting Lipid Synthesis and Depleting NADPH for Antioxidant Defenses.
Esther Aguilar, Pauline Esteves, +9 authors, Marie-Clotilde Alves-Guerra.
Cell Rep, 2019 Aug 29; 28(9). PMID: 31461648    Free PMC article.
Integrated Non-targeted and Targeted Metabolomics Uncovers Amino Acid Markers of Oral Squamous Cell Carcinoma.
Xi-Hu Yang, Yue Jing, +6 authors, Yan-Hong Ni.
Front Oncol, 2020 May 01; 10. PMID: 32351881    Free PMC article.
Unveiling dynamic metabolic signatures in human induced pluripotent and neural stem cells.
João Vasconcelos E Sá, Daniel Simão, +5 authors, Manuel J T Carrondo.
PLoS Comput Biol, 2020 Apr 17; 16(4). PMID: 32298259    Free PMC article.
The 'Achilles Heel' of Metabolism in Renal Cell Carcinoma: Glutaminase Inhibition as a Rational Treatment Strategy.
Christian R Hoerner, Viola J Chen, Alice C Fan.
Kidney Cancer, 2019 Mar 12; 3(1). PMID: 30854496    Free PMC article.
Review.
The heterocyclic compound Tempol inhibits the growth of cancer cells by interfering with glutamine metabolism.
Shuangyan Ye, Pengfei Xu, +18 authors, Qiuzhen Liu.
Cell Death Dis, 2020 May 06; 11(5). PMID: 32366855    Free PMC article.
Drosophila estrogen-related receptor directs a transcriptional switch that supports adult glycolysis and lipogenesis.
Katherine Beebe, Marcy M Robins, +3 authors, Carl S Thummel.
Genes Dev, 2020 Mar 14; 34(9-10). PMID: 32165409    Free PMC article.
Insulin-like growth factor 1-induced enolase 2 deacetylation by HDAC3 promotes metastasis of pancreatic cancer.
Yan Zheng, Chao Wu, +16 authors, Qiongzhu Dong.
Signal Transduct Target Ther, 2020 May 14; 5(1). PMID: 32398667    Free PMC article.
Circadian Clocks and Cancer: Timekeeping Governs Cellular Metabolism.
Amandine Verlande, Selma Masri.
Trends Endocrinol Metab, 2019 Jun 04; 30(7). PMID: 31155396    Free PMC article.
Review.
Inhibition of the polyamine synthesis enzyme ornithine decarboxylase sensitizes triple-negative breast cancer cells to cytotoxic chemotherapy.
Renee C Geck, Jackson R Foley, +3 authors, Alex Toker.
J Biol Chem, 2020 Mar 07; 295(19). PMID: 32139506    Free PMC article.
Potent Anticancer Effect of the Natural Steroidal Saponin Gracillin Is Produced by Inhibiting Glycolysis and Oxidative Phosphorylation-Mediated Bioenergetics.
Hye-Young Min, Honglan Pei, +6 authors, Ho-Young Lee.
Cancers (Basel), 2020 Apr 12; 12(4). PMID: 32276500    Free PMC article.
Disrupting Mitochondrial Pyruvate Uptake Directs Glutamine into the TCA Cycle away from Glutathione Synthesis and Impairs Hepatocellular Tumorigenesis.
Sean C Tompkins, Ryan D Sheldon, +12 authors, Eric B Taylor.
Cell Rep, 2019 Sep 05; 28(10). PMID: 31484072    Free PMC article.
Synthetic Sphingolipids with 1,2-Pyridazine Appendages Improve Antiproliferative Activity in Human Cancer Cell Lines.
Sylvestre P J T Bachollet, Vito Vece, +7 authors, Stephen Hanessian.
ACS Med Chem Lett, 2020 May 22; 11(5). PMID: 32435371    Free PMC article.
Glutamine independence is a selectable feature of pluripotent stem cells.
Santosha A Vardhana, Paige K Arnold, +6 authors, Lydia W S Finley.
Nat Metab, 2019 Sep 13; 1(7). PMID: 31511848    Free PMC article.
Translational and HIF-1α-Dependent Metabolic Reprogramming Underpin Metabolic Plasticity and Responses to Kinase Inhibitors and Biguanides.
Laura Hulea, Simon-Pierre Gravel, +25 authors, Ivan Topisirovic.
Cell Metab, 2018 Sep 25; 28(6). PMID: 30244971    Free PMC article.
Parkin on serine: a Parkinson disease gene suppresses serine synthesis in cancer.
W Brian Dalton.
J Clin Invest, 2020 May 19; 130(6). PMID: 32420915    Free PMC article.
Molecular Imaging of the Tumor Microenvironment Reveals the Relationship between Tumor Oxygenation, Glucose Uptake, and Glycolysis in Pancreatic Ductal Adenocarcinoma.
Kazutoshi Yamamoto, Jeffrey R Brender, +10 authors, Murali C Krishna.
Cancer Res, 2020 Apr 05; 80(11). PMID: 32245793    Free PMC article.
Epigenetics and metabolism at the crossroads of stress-induced plasticity, stemness and therapeutic resistance in cancer.
Dinoop Ravindran Menon, Heinz Hammerlindl, +2 authors, Mayumi Fujita.
Theranostics, 2020 Jun 03; 10(14). PMID: 32483452    Free PMC article.
Review.
TGFβ-induced metabolic reprogramming during epithelial-to-mesenchymal transition in cancer.
Wan Hua, Peter Ten Dijke, +2 authors, Marten Hornsveld.
Cell Mol Life Sci, 2019 Dec 12; 77(11). PMID: 31822964    Free PMC article.
Review.
Metabolic Reprogramming and Epithelial-Mesenchymal Plasticity: Opportunities and Challenges for Cancer Therapy.
Nai-Yun Sun, Muh-Hwa Yang.
Front Oncol, 2020 Jun 09; 10. PMID: 32509584    Free PMC article.
Review.
Proteomic Profiling of Colon Cancer Tissues: Discovery of New Candidate Biomarkers.
Miriam Buttacavoli, Nadia Ninfa Albanese, +3 authors, Patrizia Cancemi.
Int J Mol Sci, 2020 May 02; 21(9). PMID: 32353950    Free PMC article.
Tumors defective in homologous recombination rely on oxidative metabolism: relevance to treatments with PARP inhibitors.
Álvaro Lahiguera, Petra Hyroššová, +22 authors, Francesc Viñals.
EMBO Mol Med, 2020 May 14; 12(6). PMID: 32400970    Free PMC article.
Survival model methods for analyses of cancer incidence trends in young adults.
Wan Yang, Rebecca D Kehm, Mary Beth Terry.
Stat Med, 2020 Feb 06; 39(7). PMID: 32022306    Free PMC article.
Normal Hematopoetic Stem and Progenitor Cells Can Exhibit Metabolic Flexibility Similar to Cancer Cells.
Marija Vlaski-Lafarge, Veronique Labat, +6 authors, Zoran Ivanovic.
Front Oncol, 2020 Jun 13; 10. PMID: 32528878    Free PMC article.
Large-Scale Differential Gene Expression Transcriptomic Analysis Identifies a Metabolic Signature Shared by All Cancer Cells.
Areej Abu Rmaileh, Balakrishnan Solaimuthu, +5 authors, Yoav D Shaul.
Biomolecules, 2020 May 06; 10(5). PMID: 32365991    Free PMC article.
Thioholgamide A, a New Anti-Proliferative Anti-Tumor Agent, Modulates Macrophage Polarization and Metabolism.
Charlotte Dahlem, Wei Xiong Siow, +9 authors, Alexandra K Kiemer.
Cancers (Basel), 2020 May 23; 12(5). PMID: 32438733    Free PMC article.
PCK1 and DHODH drive colorectal cancer liver metastatic colonization and hypoxic growth by promoting nucleotide synthesis.
Norihiro Yamaguchi, Ethan M Weinberg, +9 authors, Sohail F Tavazoie.
Elife, 2019 Dec 17; 8. PMID: 31841108    Free PMC article.
The Molecular Link from Diet to Cancer Cell Metabolism.
Shree Bose, Annamarie E Allen, Jason W Locasale.
Mol Cell, 2020 Jun 07; 78(6). PMID: 32504556    Free PMC article.
Review.
Compartmentalised acyl-CoA metabolism and roles in chromatin regulation.
Sophie Trefely, Claudia D Lovell, Nathaniel W Snyder, Kathryn E Wellen.
Mol Metab, 2020 Mar 23; 38. PMID: 32199817    Free PMC article.
Review.
New High-Throughput Screening Identifies Compounds That Reduce Viability Specifically in Liver Cancer Cells That Express High Levels of SALL4 by Inhibiting Oxidative Phosphorylation.
Justin L Tan, Feng Li, +34 authors, Li Chai.
Gastroenterology, 2019 Aug 26; 157(6). PMID: 31446059    Free PMC article.
Genomic and transcriptomic profiling of carcinogenesis in patients with familial adenomatous polyposis.
Jingyun Li, Rui Wang, +9 authors, Fuchou Tang.
Gut, 2019 Nov 21; 69(7). PMID: 31744909    Free PMC article.
Myc as a Regulator of Ribosome Biogenesis and Cell Competition: A Link to Cancer.
Francesca Destefanis, Valeria Manara, Paola Bellosta.
Int J Mol Sci, 2020 Jun 11; 21(11). PMID: 32516899    Free PMC article.
Review.
Evaluation of intercellular communication between breast cancer cells and adipose-derived stem cells via passive diffusion in a two-layer microfluidic device.
Sharif M Rahman, Joshua M Campbell, +4 authors, Adam T Melvin.
Lab Chip, 2020 May 08; 20(11). PMID: 32379852    Free PMC article.
Synergisms of genome and metabolism stabilizing antitumor therapy (GMSAT) in human breast and colon cancer cell lines: a novel approach to screen for synergism.
Jérôme Ruhnau, Jonas Parczyk, +2 authors, Andreas Klein.
BMC Cancer, 2020 Jul 04; 20(1). PMID: 32615946    Free PMC article.
Metabolomic Markers of Colorectal Tumor With Different Clinicopathological Features.
Zhiping Long, Junde Zhou, +10 authors, Yunfu Cui.
Front Oncol, 2020 Jul 07; 10. PMID: 32626659    Free PMC article.
Hexokinase 2 displacement from mitochondria-associated membranes prompts Ca2+ -dependent death of cancer cells.
Francesco Ciscato, Riccardo Filadi, +10 authors, Andrea Rasola.
EMBO Rep, 2020 May 10; 21(7). PMID: 32383545    Free PMC article.
Epigenetic Reprogramming of Cancer-Associated Fibroblasts Deregulates Glucose Metabolism and Facilitates Progression of Breast Cancer.
Lisa M Becker, Joyce T O'Connell, +14 authors, Raghu Kalluri.
Cell Rep, 2020 Jun 04; 31(9). PMID: 32492417    Free PMC article.
Targeting Metabolism to Improve the Tumor Microenvironment for Cancer Immunotherapy.
Jackie E Bader, Kelsey Voss, Jeffrey C Rathmell.
Mol Cell, 2020 Jun 20; 78(6). PMID: 32559423    Free PMC article.
Review.
Maintaining cytosolic aspartate levels is a major function of the TCA cycle in proliferating cells.
H Furkan Alkan, Juliane G Bogner-Strauss.
Mol Cell Oncol, 2019 Sep 19; 6(5). PMID: 31528687    Free PMC article.
Mechanisms underlying the predictive power of high skeletal muscle uptake of FDG in amyotrophic lateral sclerosis.
Cecilia Marini, Vanessa Cossu, +22 authors, Gianmario Sambuceti.
EJNMMI Res, 2020 Jul 09; 10(1). PMID: 32638178    Free PMC article.
Mass spectrometry imaging-based metabolomics to visualize the spatially resolved reprogramming of carnitine metabolism in breast cancer.
Chenglong Sun, Fukai Wang, +2 authors, Xiao Wang.
Theranostics, 2020 Jul 10; 10(16). PMID: 32641979    Free PMC article.
Metabolic Fingerprinting Links Oncogenic PIK3CA with Enhanced Arachidonic Acid-Derived Eicosanoids.
Nikos Koundouros, Evdoxia Karali, +15 authors, George Poulogiannis.
Cell, 2020 Jun 20; 181(7). PMID: 32559461    Free PMC article.
Untargeted Metabolomics Identifies Key Metabolic Pathways Altered by Thymoquinone in Leukemic Cancer Cells.
Asma Ahmed AlGhamdi, Mohammed Razeeth Shait Mohammed, +4 authors, Hani Choudhry.
Nutrients, 2020 Jun 21; 12(6). PMID: 32560283    Free PMC article.
Metabolic Landscape of a Genetically Engineered Mouse Model of IDH1 Mutant Glioma.
Victor Ruiz-Rodado, Tomohiro Seki, +7 authors, Mioara Larion.
Cancers (Basel), 2020 Jun 25; 12(6). PMID: 32575619    Free PMC article.
Exploiting Cancer's Tactics to Make Cancer a Manageable Chronic Disease.
Kambiz Afrasiabi, Mark E Linskey, Yi-Hong Zhou.
Cancers (Basel), 2020 Jun 26; 12(6). PMID: 32580319    Free PMC article.
Review.
Metabolic pathway alterations in microvascular endothelial cells in response to hypoxia.
Emily B Cohen, Renee C Geck, Alex Toker.
PLoS One, 2020 Jul 10; 15(7). PMID: 32645038    Free PMC article.
Metabolic Escape Routes of Cancer Stem Cells and Therapeutic Opportunities.
Alice Turdo, Gaetana Porcelli, +7 authors, Giorgio Stassi.
Cancers (Basel), 2020 Jun 04; 12(6). PMID: 32486505    Free PMC article.
Review.
Cancer Cells Don't Live Alone: Metabolic Communication within Tumor Microenvironments.
Fuming Li, M Celeste Simon.
Dev Cell, 2020 Jul 09; 54(2). PMID: 32640203    Free PMC article.
Review.
Nitrogen Metabolism in Cancer and Immunity.
Kiran Kurmi, Marcia C Haigis.
Trends Cell Biol, 2020 Apr 18; 30(5). PMID: 32302552    Free PMC article.
Review.
Identification of an ATP metabolism-related signature associated with prognosis and immune microenvironment in gliomas.
Ruoyu Huang, Guanzhang Li, +5 authors, Fan Wu.
Cancer Sci, 2020 May 18; 111(7). PMID: 32415873    Free PMC article.
Comprehensive analysis and establishment of a prediction model of alternative splicing events reveal the prognostic predictor and immune microenvironment signatures in triple negative breast cancer.
Shanshan Yu, Chuan Hu, +9 authors, Wenfeng Li.
J Transl Med, 2020 Jul 30; 18(1). PMID: 32723333    Free PMC article.
Mitochondrial pyruvate import is a metabolic vulnerability in androgen receptor-driven prostate cancer.
David A Bader, Sean M Hartig, +18 authors, Sean E McGuire.
Nat Metab, 2019 Jun 15; 1(1). PMID: 31198906    Free PMC article.
Highly Cited.
Imaging Mass Spectrometry Reveals Tumor Metabolic Heterogeneity.
Yang Zhang, Christelle Guillermier, +9 authors, Matthew L Steinhauser.
iScience, 2020 Jul 28; 23(8). PMID: 32712466    Free PMC article.
Dissecting cell-type-specific metabolism in pancreatic ductal adenocarcinoma.
Allison N Lau, Zhaoqi Li, +16 authors, Matthew G Vander Heiden.
Elife, 2020 Jul 11; 9. PMID: 32648540    Free PMC article.
Dynamically Shaping Chaperones. Allosteric Modulators of HSP90 Family as Regulatory Tools of Cell Metabolism in Neoplastic Progression.
Carlos Sanchez-Martin, Stefano A Serapian, Giorgio Colombo, Andrea Rasola.
Front Oncol, 2020 Aug 09; 10. PMID: 32766157    Free PMC article.
Review.
Glucose Starvation-Induced Rapid Death of Nrf1α-Deficient, but Not Nrf2-Deficient, Hepatoma Cells Results from Its Fatal Defects in the Redox Metabolism Reprogramming.
Yu-Ping Zhu, Ze Zheng, Yuancai Xiang, Yiguo Zhang.
Oxid Med Cell Longev, 2020 Aug 11; 2020. PMID: 32774674    Free PMC article.
PKCλ/ι Loss Induces Autophagy, Oxidative Phosphorylation, and NRF2 to Promote Liver Cancer Progression.
Yotaro Kudo, Masayuki Sugimoto, +16 authors, Jorge Moscat.
Cancer Cell, 2020 Jun 27; 38(2). PMID: 32589943    Free PMC article.
Identifying strategies to target the metabolic flexibility of tumours.
Andrés Méndez-Lucas, Wei Lin, +13 authors, Mariia Yuneva.
Nat Metab, 2020 Jul 23; 2(4). PMID: 32694609    Free PMC article.
A CRISPR knockout negative screen reveals synergy between CDKs inhibitor and metformin in the treatment of human cancer in vitro and in vivo.
Yarui Ma, Qing Zhu, +6 authors, Yuchen Jiao.
Signal Transduct Target Ther, 2020 Aug 20; 5(1). PMID: 32811807    Free PMC article.
Novel Antiproliferative Biphenyl Nicotinamide: NMR Metabolomic Study of its Effect on the MCF-7 Cell in Comparison with Cisplatin and Vinblastine.
Laura Del Coco, Maria Majellaro, +3 authors, Francesco Paolo Fanizzi.
Molecules, 2020 Aug 06; 25(15). PMID: 32752035    Free PMC article.
Cytosolic ME1 integrated with mitochondrial IDH2 supports tumor growth and metastasis.
Chang Shao, Wenjie Lu, +6 authors, Haiping Hao.
Redox Biol, 2020 Aug 28; 36. PMID: 32853879    Free PMC article.
Mitochondrial Metabolism in PDAC: From Better Knowledge to New Targeting Strategies.
Gabriela Reyes-Castellanos, Rawand Masoud, Alice Carrier.
Biomedicines, 2020 Aug 07; 8(8). PMID: 32756381    Free PMC article.
Review.
Stable Isotope Tracing Metabolomics to Investigate the Metabolic Activity of Bioactive Compounds for Cancer Prevention and Treatment.
Feroza K Choudhury, G Lavender Hackman, Alessia Lodi, Stefano Tiziani.
Cancers (Basel), 2020 Aug 07; 12(8). PMID: 32756373    Free PMC article.
Review.
Initial evaluation of (4S)-4-(3-[18F]fluoropropyl)-L-glutamate (FSPG) PET/CT imaging in patients with head and neck cancer, colorectal cancer, or non-Hodgkin lymphoma.
Sonya Y Park, Camila Mosci, +9 authors, Erik S Mittra.
EJNMMI Res, 2020 Aug 29; 10(1). PMID: 32857284    Free PMC article.
Reactivation of Dihydroorotate Dehydrogenase-Driven Pyrimidine Biosynthesis Restores Tumor Growth of Respiration-Deficient Cancer Cells.
Martina Bajzikova, Jaromira Kovarova, +46 authors, Jiri Neuzil.
Cell Metab, 2018 Nov 20; 29(2). PMID: 30449682    Free PMC article.
Highly Cited.
Mutant p53 on the Path to Metastasis.
Qiaosi Tang, Zhenyi Su, Wei Gu, Anil K Rustgi.
Trends Cancer, 2020 Jan 19; 6(1). PMID: 31952783    Free PMC article.
Review.
Nitrogen Trapping as a Therapeutic Strategy in Tumors with Mitochondrial Dysfunction.
Hanumantha Rao Madala, Iiro Taneli Helenius, +13 authors, Jing-Ruey Joanna Yeh.
Cancer Res, 2020 Jul 12; 80(17). PMID: 32651261    Free PMC article.
Mitochondrial Metabolism as a Target for Cancer Therapy.
Karthik Vasan, Marie Werner, Navdeep S Chandel.
Cell Metab, 2020 Jul 16; 32(3). PMID: 32668195    Free PMC article.
Review.
GLUT3 induced by AMPK/CREB1 axis is key for withstanding energy stress and augments the efficacy of current colorectal cancer therapies.
Weixing Dai, Ye Xu, +13 authors, Guoxiang Cai.
Signal Transduct Target Ther, 2020 Sep 03; 5(1). PMID: 32873793    Free PMC article.
The glutathione peroxidase 8 (GPX8)/IL-6/STAT3 axis is essential in maintaining an aggressive breast cancer phenotype.
Anees Khatib, Balakrishnan Solaimuthu, +7 authors, Yoav D Shaul.
Proc Natl Acad Sci U S A, 2020 Aug 21; 117(35). PMID: 32817494    Free PMC article.
Lysine oxidase exposes a dependency on the thioredoxin antioxidant pathway in triple-negative breast cancer cells.
Olga E Chepikova, Dmitry Malin, +3 authors, Vincent L Cryns.
Breast Cancer Res Treat, 2020 Jul 23; 183(3). PMID: 32696316    Free PMC article.
Location, Location, Location: Compartmentalization of NAD+ Synthesis and Functions in Mammalian Cells.
Xiaolu A Cambronne, W Lee Kraus.
Trends Biochem Sci, 2020 Jul 01; 45(10). PMID: 32595066    Free PMC article.
Review.
Prognostic implications of metabolism-associated gene signatures in colorectal cancer.
Yandong Miao, Qiutian Li, +4 authors, Denghai Mi.
PeerJ, 2020 Sep 22; 8. PMID: 32953273    Free PMC article.
Branched chain amino acid metabolism and cancer: the importance of keeping things in context.
Elizabeth M Selwan, Aimee L Edinger.
Transl Cancer Res, 2017 May 01; 6(Suppl 3). PMID: 30613481    Free PMC article.
Emerging Therapies for Acute Myelogenus Leukemia Patients Targeting Apoptosis and Mitochondrial Metabolism.
Germana Castelli, Elvira Pelosi, Ugo Testa.
Cancers (Basel), 2019 Mar 01; 11(2). PMID: 30813354    Free PMC article.
Review.
How clinical imaging can assess cancer biology.
Roberto García-Figueiras, Sandra Baleato-González, +7 authors, Herbert Alberto Vargas.
Insights Imaging, 2019 Mar 05; 10(1). PMID: 30830470    Free PMC article.
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Macrophage Origin, Metabolic Reprogramming and IL-1 Signaling: Promises and Pitfalls in Lung Cancer.
Emma Guilbaud, Emmanuel L Gautier, Laurent Yvan-Charvet.
Cancers (Basel), 2019 Mar 06; 11(3). PMID: 30832375    Free PMC article.
Review.
Metabolomics Contributions to the Discovery of Prostate Cancer Biomarkers.
Nuria Gómez-Cebrián, Ayelén Rojas-Benedicto, +3 authors, Leonor Puchades-Carrasco.
Metabolites, 2019 Mar 13; 9(3). PMID: 30857149    Free PMC article.
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Drosophila melanogaster: A Model Organism to Study Cancer.
Zhasmine Mirzoyan, Manuela Sollazzo, +3 authors, Paola Bellosta.
Front Genet, 2019 Mar 19; 10. PMID: 30881374    Free PMC article.
Highly Cited. Review.
The PGC-1/ERR network and its role in precision oncology.
Humberto De Vitto, Ann M Bode, Zigang Dong.
NPJ Precis Oncol, 2019 Mar 27; 3. PMID: 30911677    Free PMC article.
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Identification of a Clinically Relevant Signature for Early Progression in KRAS-Driven Lung Adenocarcinoma.
Sarah Neidler, Björn Kruspig, +10 authors, Daniel J Murphy.
Cancers (Basel), 2019 Apr 30; 11(5). PMID: 31032816    Free PMC article.
Activation of LXR Receptors and Inhibition of TRAP1 Causes Synthetic Lethality in Solid Tumors.
Trang Thi Thu Nguyen, Chiaki Tsuge Ishida, +4 authors, Markus D Siegelin.
Cancers (Basel), 2019 Jun 12; 11(6). PMID: 31181660    Free PMC article.
Starve Cancer Cells of Glutamine: Break the Spell or Make a Hungry Monster?
Jie Jiang, Sankalp Srivastava, Ji Zhang.
Cancers (Basel), 2019 Jun 20; 11(6). PMID: 31212591    Free PMC article.
Review.
Mitochondrial stress delays tumorigenesis in a Li-Fraumeni syndrome mouse model.
Matthew P Donnelly, Jie Li, Paul M Hwang.
Cell Stress, 2019 Jun 22; 3(4). PMID: 31225506    Free PMC article.
Role of IDO and TDO in Cancers and Related Diseases and the Therapeutic Implications.
Zixiang Ye, Linxiu Yue, +2 authors, Tao Wu.
J Cancer, 2019 Jul 02; 10(12). PMID: 31258785    Free PMC article.
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The role of Wnt signaling pathway in tumor metabolic reprogramming.
Yongzhen Mo, Yumin Wang, +9 authors, Can Guo.
J Cancer, 2019 Jul 25; 10(16). PMID: 31333796    Free PMC article.
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Topical Diclofenac Reprograms Metabolism and Immune Cell Infiltration in Actinic Keratosis.
Katrin Singer, Katja Dettmer, +10 authors, Elisabeth Datz.
Front Oncol, 2019 Jul 25; 9. PMID: 31334125    Free PMC article.
Malic enzyme 1 (ME1) is a potential oncogene in gastric cancer cells and is associated with poor survival of gastric cancer patients.
Yanyan Shi, Siliang Zhou, +3 authors, Shigang Ding.
Onco Targets Ther, 2019 Aug 03; 12. PMID: 31371996    Free PMC article.
Cancer Metabolism and the Evasion of Apoptotic Cell Death.
Aditi Sharma, Lawrence H Boise, Mala Shanmugam.
Cancers (Basel), 2019 Aug 14; 11(8). PMID: 31405035    Free PMC article.
Review.
Somatic multicellularity as a satisficing solution to the prediction-error minimization problem.
Chris Fields, Michael Levin.
Commun Integr Biol, 2019 Aug 16; 12(1). PMID: 31413788    Free PMC article.
Amino Acid Transporters as Targets for Cancer Therapy: Why, Where, When, and How.
Stefan Bröer.
Int J Mol Sci, 2020 Aug 30; 21(17). PMID: 32859034    Free PMC article.
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Pickled Vegetables Intake Impacts the Metabolites for Gastric Cancer.
Shuangfeng Yang, Yanping Lv, +3 authors, Yulan Lin.
Cancer Manag Res, 2020 Sep 29; 12. PMID: 32982422    Free PMC article.
mTOR-mediated cancer drug resistance suppresses autophagy and generates a druggable metabolic vulnerability.
Niklas Gremke, Pierfrancesco Polo, +9 authors, Thorsten Stiewe.
Nat Commun, 2020 Sep 19; 11(1). PMID: 32943635    Free PMC article.
Combined analysis of RNA-sequence and microarray data reveals effective metabolism-based prognostic signature for neuroblastoma.
Xinyao Meng, Chenzhao Feng, +2 authors, Xiang Zhao.
J Cell Mol Med, 2020 Jul 20; 24(18). PMID: 32683778    Free PMC article.
Oxidative pentose phosphate pathway and glucose anaplerosis support maintenance of mitochondrial NADPH pool under mitochondrial oxidative stress.
Sun Jin Moon, Wentao Dong, Gregory N Stephanopoulos, Hadley D Sikes.
Bioeng Transl Med, 2020 Oct 03; 5(3). PMID: 33005744    Free PMC article.
Nutrient metabolism and cancer in the in vivo context: a metabolic game of give and take.
Patricia Altea-Manzano, Alejandro M Cuadros, Lindsay A Broadfield, Sarah-Maria Fendt.
EMBO Rep, 2020 Sep 24; 21(10). PMID: 32964587    Free PMC article.
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A powerful drug combination strategy targeting glutamine addiction for the treatment of human liver cancer.
Haojie Jin, Siying Wang, +11 authors, Rene Bernards.
Elife, 2020 Oct 06; 9. PMID: 33016874    Free PMC article.
The knockdown of the sepiapterin reductase gene suppresses the proliferation of breast cancer by inducing ROS-mediated apoptosis.
Xiaojing Zhang, Yuzhong Chen, +4 authors, Xianfu Liu.
Int J Clin Exp Pathol, 2020 Oct 13; 13(9). PMID: 33042327    Free PMC article.
The role of Nrf2/PIWIL2/purine metabolism axis in controlling radiation-induced lung fibrosis.
Guan-Lian Zou, Xiao-Ran Zhang, +4 authors, Yan-Yang Wang.
Am J Cancer Res, 2020 Oct 13; 10(9). PMID: 33042615    Free PMC article.
Niche-Selective Inhibition of Pathogenic Th17 Cells by Targeting Metabolic Redundancy.
Lin Wu, Kate E R Hollinshead, +14 authors, Dan R Littman.
Cell, 2020 Jul 03; 182(3). PMID: 32615085    Free PMC article.
High expression levels of pyrimidine metabolic rate-limiting enzymes are adverse prognostic factors in lung adenocarcinoma: a study based on The Cancer Genome Atlas and Gene Expression Omnibus datasets.
Haiwei Wang, Xinrui Wang, +2 authors, Hua Cao.
Purinergic Signal, 2020 Jul 09; 16(3). PMID: 32638267    Free PMC article.
Metabolomic profiling of tumor-infiltrating macrophages during tumor growth.
Naoki Umemura, Masahiro Sugimoto, +2 authors, Hiroshi Sakagami.
Cancer Immunol Immunother, 2020 Jun 11; 69(11). PMID: 32518979    Free PMC article.
A Molecular Subtype Model for Liver HBV-Related Hepatocellular Carcinoma Patients Based on Immune-Related Genes.
Qiyao Zhang, Xiao Yu, +2 authors, Wenzhi Guo.
Front Oncol, 2020 Oct 20; 10. PMID: 33072587    Free PMC article.
Propofol disrupts cell carcinogenesis and aerobic glycolysis by regulating circTADA2A/miR-455-3p/FOXM1 axis in lung cancer.
Huaping Zhao, Hua Wei, +5 authors, Jianjun Yang.
Cell Cycle, 2020 Aug 29; 19(19). PMID: 32857667    Free PMC article.
Membrane Transporters for Amino Acids as Players of Cancer Metabolic Rewiring.
Mariafrancesca Scalise, Lara Console, +3 authors, Cesare Indiveri.
Cells, 2020 Sep 10; 9(9). PMID: 32899180    Free PMC article.
Review.
CircECE1 activates energy metabolism in osteosarcoma by stabilizing c-Myc.
Shuying Shen, Teng Yao, +3 authors, Jianjun Ma.
Mol Cancer, 2020 Oct 28; 19(1). PMID: 33106166    Free PMC article.
Metabolites modulate the functional state of human uridine phosphorylase I.
Yu-Ting Huang, Pei-Chin Yeh, Shih-Chun Lan, Pei-Fen Liu.
Protein Sci, 2020 Aug 31; 29(11). PMID: 32864839    Free PMC article.
High Cysteinyl Leukotriene Receptor 1 Expression Correlates with Poor Survival of Uveal Melanoma Patients and Cognate Antagonist Drugs Modulate the Growth, Cancer Secretome, and Metabolism of Uveal Melanoma Cells.
Kayleigh Slater, Aisling B Heeran, +15 authors, Breandán N Kennedy.
Cancers (Basel), 2020 Oct 18; 12(10). PMID: 33066024    Free PMC article.
Overexpression of family with sequence similarity 134, member B (FAM134B) in colon cancers and its tumor suppressive properties in vitro.
Katherine Ting-Wei Lee, Farhadul Islam, +5 authors, Alfred Kin-Yan Lam.
Cancer Biol Ther, 2020 Aug 29; 21(10). PMID: 32857678    Free PMC article.
Distribution and prognostic significance of gluconeogenesis and glycolysis in lung cancer.
Elisabeth Smolle, Petra Leko, +8 authors, Katharina Leithner.
Mol Oncol, 2020 Aug 11; 14(11). PMID: 32777161    Free PMC article.
Androgen Receptor Signaling and Metabolic and Cellular Plasticity During Progression to Castration Resistant Prostate Cancer.
Takuma Uo, Cynthia C Sprenger, Stephen R Plymate.
Front Oncol, 2020 Nov 10; 10. PMID: 33163409    Free PMC article.
Review.
Enhanced antitumor effects of follicle-stimulating hormone receptor-mediated hexokinase-2 depletion on ovarian cancer mediated by a shift in glucose metabolism.
Meng Zhang, Qiyu Liu, +6 authors, Xiaoyan Zhang.
J Nanobiotechnology, 2020 Nov 09; 18(1). PMID: 33160373    Free PMC article.
Prognostic Implication of a Metabolism-Associated Gene Signature in Lung Adenocarcinoma.
Lulu He, Jiaxian Chen, +2 authors, Jun Li.
Mol Ther Oncolytics, 2020 Nov 20; 19. PMID: 33209981    Free PMC article.
Development and Validation of a Scoring System Based on 9 Glycolysis-Related Genes for Prognosis Prediction in Gastric Cancer.
Tianqi Luo, Yufei Du, +5 authors, Yingbo Chen.
Technol Cancer Res Treat, 2020 Nov 10; 19. PMID: 33161837    Free PMC article.
Hyperactive CDK2 Activity in Basal-like Breast Cancer Imposes a Genome Integrity Liability that Can Be Exploited by Targeting DNA Polymerase ε.
Vladislav O Sviderskiy, Lili Blumenberg, +14 authors, Richard Possemato.
Mol Cell, 2020 Nov 06; 80(4). PMID: 33152268    Free PMC article.
Metabolite Sensing GPCRs: Promising Therapeutic Targets for Cancer Treatment?
Jesús Cosín-Roger, Dolores Ortiz-Masia, Maria Dolores Barrachina, Sara Calatayud.
Cells, 2020 Oct 30; 9(11). PMID: 33113952    Free PMC article.
Review.
Toxoplasma gondii GRA9 Regulates the Activation of NLRP3 Inflammasome to Exert Anti-Septic Effects in Mice.
Jae-Sung Kim, Seok-Jun Mun, +6 authors, Chul-Su Yang.
Int J Mol Sci, 2020 Nov 14; 21(22). PMID: 33182702    Free PMC article.
"The Loss of Golden Touch": Mitochondria-Organelle Interactions, Metabolism, and Cancer.
Matteo Audano, Silvia Pedretti, +4 authors, Nico Mitro.
Cells, 2020 Nov 26; 9(11). PMID: 33233365    Free PMC article.
Review.
Translational Control through Differential Ribosome Pausing during Amino Acid Limitation in Mammalian Cells.
Alicia M Darnell, Arvind R Subramaniam, Erin K O'Shea.
Mol Cell, 2018 Jul 22; 71(2). PMID: 30029003    Free PMC article.
Highly Cited.
Reactive oxygen species-induced alterations in H19-Igf2 methylation patterns, seminal plasma metabolites, and semen quality.
Mahsa Darbandi, Sara Darbandi, +11 authors, Mohammad Reza Sadeghi.
J Assist Reprod Genet, 2018 Nov 02; 36(2). PMID: 30382470    Free PMC article.
The ERK and JNK pathways in the regulation of metabolic reprogramming.
Salvatore Papa, Pui Man Choy, Concetta Bubici.
Oncogene, 2018 Nov 30; 38(13). PMID: 30487597    Free PMC article.
Highly Cited. Review.
Increased lactate dehydrogenase activity is dispensable in squamous carcinoma cells of origin.
A Flores, S Sandoval-Gonzalez, +8 authors, W E Lowry.
Nat Commun, 2019 Jan 11; 10(1). PMID: 30626875    Free PMC article.
A chemical biology screen identifies a vulnerability of neuroendocrine cancer cells to SQLE inhibition.
Christopher E Mahoney, David Pirman, +26 authors, Gromoslaw A Smolen.
Nat Commun, 2019 Jan 11; 10(1). PMID: 30626880    Free PMC article.
Autophagy modulates lipid metabolism to maintain metabolic flexibility for Lkb1-deficient Kras-driven lung tumorigenesis.
Vrushank Bhatt, Khoosheh Khayati, +4 authors, Jessie Yanxiang Guo.
Genes Dev, 2019 Jan 30; 33(3-4). PMID: 30692209    Free PMC article.
Mitochondria-centric bioenergetic characteristics in cancer stem-like cells.
Min-Kyue Shin, Jae-Ho Cheong.
Arch Pharm Res, 2019 Feb 17; 42(2). PMID: 30771209    Free PMC article.
Review.
Development of Anthraquinone Analogues as Phosphoglycerate Mutase 1 Inhibitors.
Ke Huang, Lulu Jiang, +2 authors, Lu Zhou.
Molecules, 2019 Mar 02; 24(5). PMID: 30818883    Free PMC article.
Obesogenic high-fat diet heightens aerobic glycolysis through hyperactivation of oncogenic KRAS.
Dan Wang, Yawei Bi, +9 authors, Weiqin Lu.
Cell Commun Signal, 2019 Mar 02; 17(1). PMID: 30819189    Free PMC article.
Effects of Long-Term Citrate Treatment in the PC3 Prostate Cancer Cell Line.
Carmen Caiazza, Massimo D'Agostino, +5 authors, Donatella Tramontano.
Int J Mol Sci, 2019 May 31; 20(11). PMID: 31141937    Free PMC article.
Metabolic signatures of cancer cells and stem cells.
Andrew M Intlekofer, Lydia W S Finley.
Nat Metab, 2019 Jun 28; 1(2). PMID: 31245788    Free PMC article.
Highly Cited. Review.
Functional and mechanistic studies reveal MAGEA3 as a pro-survival factor in pancreatic cancer cells.
Biswajit Das, Shantibhusan Senapati.
J Exp Clin Cancer Res, 2019 Jul 10; 38(1). PMID: 31287009    Free PMC article.
The Warburg Effect Is Associated With Tumor Aggressiveness in Testicular Germ Cell Tumors.
Murilo Bonatelli, Eduardo C A Silva, +4 authors, Céline Pinheiro.
Front Endocrinol (Lausanne), 2019 Jul 19; 10. PMID: 31316469    Free PMC article.
Targeting Cellular Metabolism Modulates Head and Neck Oncogenesis.
Yi-Ta Hsieh, Yi-Fen Chen, +2 authors, Wan-Chun Li.
Int J Mol Sci, 2019 Aug 17; 20(16). PMID: 31416244    Free PMC article.
Review.
Hepatic Tumor Microenvironments and Effects on NK Cell Phenotype and Function.
Julián Piñeiro Fernández, Kimberly A Luddy, Cathal Harmon, Cliona O'Farrelly.
Int J Mol Sci, 2019 Aug 28; 20(17). PMID: 31450598    Free PMC article.
Review.
Critical role of ASCT2-mediated amino acid metabolism in promoting leukaemia development and progression.
Fang Ni, Wen-Mei Yu, +7 authors, Cheng-Kui Qu.
Nat Metab, 2019 Sep 20; 1(3). PMID: 31535081    Free PMC article.
The malate-aspartate shuttle (Borst cycle): How it started and developed into a major metabolic pathway.
Piet Borst.
IUBMB Life, 2020 Sep 12; 72(11). PMID: 32916028    Free PMC article.
Review.
TRAP1 enhances Warburg metabolism through modulation of PFK1 expression/activity and favors resistance to EGFR inhibitors in human colorectal carcinomas.
Francesca Maddalena, Valentina Condelli, +11 authors, Matteo Landriscina.
Mol Oncol, 2020 Oct 08; 14(12). PMID: 33025742    Free PMC article.
Nucleotide de novo synthesis increases breast cancer stemness and metastasis via cGMP-PKG-MAPK signaling pathway.
Yajing Lv, Xiaoshuang Wang, +7 authors, Longlong Wang.
PLoS Biol, 2020 Nov 14; 18(11). PMID: 33186350    Free PMC article.
Convergence of Plasma Metabolomics and Proteomics Analysis to Discover Signatures of High-Grade Serous Ovarian Cancer.
Hee-Sung Ahn, Jeonghun Yeom, +3 authors, Kyunggon Kim.
Cancers (Basel), 2020 Nov 25; 12(11). PMID: 33228226    Free PMC article.
Estrogen-related receptor alpha directly binds to p53 and cooperatively controls colon cancer growth through the regulation of mitochondrial biogenesis and function.
Humberto De Vitto, Joohyun Ryu, +6 authors, Zigang Dong.
Cancer Metab, 2020 Dec 12; 8(1). PMID: 33303020    Free PMC article.
D-mannose suppresses macrophage IL-1β production.
Simone Torretta, Alessandra Scagliola, +7 authors, Simone Cardaci.
Nat Commun, 2020 Dec 15; 11(1). PMID: 33311467    Free PMC article.
Microbes in Tumoral In Situ Tissues and in Tumorigenesis.
Xue Feng, Lu Han, +7 authors, Qiling Li.
Front Cell Infect Microbiol, 2020 Dec 18; 10. PMID: 33330121    Free PMC article.
Review.
Acetate: Friend or foe against breast tumour growth in the context of obesity?
Caner Yelek, Lionel Mignion, +10 authors, Bénédicte F Jordan.
J Cell Mol Med, 2020 Oct 28; 24(24). PMID: 33107196    Free PMC article.
Metabolic Regulation of Epigenetic Modifications and Cell Differentiation in Cancer.
Pasquale Saggese, Assunta Sellitto, +5 authors, Claudio Scafoglio.
Cancers (Basel), 2020 Dec 20; 12(12). PMID: 33339101    Free PMC article.
Review.
The Implications of PDK1-4 on Tumor Energy Metabolism, Aggressiveness and Therapy Resistance.
Emine Atas, Monika Oberhuber, Lukas Kenner.
Front Oncol, 2021 Jan 02; 10. PMID: 33384955    Free PMC article.
Review.
The landscape of cancer cell line metabolism.
Haoxin Li, Shaoyang Ning, +23 authors, William R Sellers.
Nat Med, 2019 May 10; 25(5). PMID: 31068703    Free PMC article.
Highly Cited.
Targeted Degradation of SLC Transporters Reveals Amenability of Multi-Pass Transmembrane Proteins to Ligand-Induced Proteolysis.
Ariel Bensimon, Mattia D Pizzagalli, +4 authors, Giulio Superti-Furga.
Cell Chem Biol, 2020 May 11; 27(6). PMID: 32386596    Free PMC article.
Tumor treating fields (TTFields) impairs aberrant glycolysis in glioblastoma as evaluated by [18F]DASA-23, a non-invasive probe of pyruvate kinase M2 (PKM2) expression.
Chirag B Patel, Corinne Beinat, +2 authors, Sanjiv S Gambhir.
Neoplasia, 2020 Nov 23; 23(1). PMID: 33221711    Free PMC article.
Functional Genomics In Vivo Reveal Metabolic Dependencies of Pancreatic Cancer Cells.
Xiphias Ge Zhu, Aleksey Chudnovskiy, +13 authors, Kıvanç Birsoy.
Cell Metab, 2020 Nov 06; 33(1). PMID: 33152324    Free PMC article.
Effect of isoform-specific HIF-1α and HIF-2α antisense oligonucleotides on tumorigenesis, inflammation and fibrosis in a hepatocellular carcinoma mouse model.
Bart Vanderborght, Kevin De Muynck, +5 authors, Lindsey Devisscher.
Oncotarget, 2021 Jan 06; 11(48). PMID: 33400730    Free PMC article.
Exploiting the metabolic dependencies of the broad amino acid transporter SLC6A14.
Francesca R Dejure, Joachim Butzer, Ralph K Lindemann, Balca R Mardin.
Oncotarget, 2021 Jan 06; 11(48). PMID: 33400734    Free PMC article.
Metabolic Constants and Plasticity of Cancer Cells in a Limiting Glucose and Glutamine Microenvironment-A Pyruvate Perspective.
Angela M Otto.
Front Oncol, 2021 Jan 12; 10. PMID: 33425750    Free PMC article.
Review.
Let-7a regulates EV secretion and mitochondrial oxidative phosphorylation by targeting SNAP23 in colorectal cancer.
You Dong Liu, Xiao Peng Zhuang, +9 authors, Dong Wang Yan.
J Exp Clin Cancer Res, 2021 Jan 16; 40(1). PMID: 33446221    Free PMC article.
Tension in tumour cells keeps metabolism high.
Nadia M E Ayad, Valerie M Weaver.
Nature, 2020 Feb 26; 578(7796). PMID: 32094916
The role of the glutamine transporter ASCT2 in antineoplastic therapy.
Estefânia Teixeira, Cláudia Silva, Fátima Martel.
Cancer Chemother Pharmacol, 2021 Jan 20; 87(4). PMID: 33464409
Review.
Serine synthesis pathway inhibition cooperates with dietary serine and glycine limitation for cancer therapy.
Mylène Tajan, Marc Hennequart, +20 authors, Karen H Vousden.
Nat Commun, 2021 Jan 16; 12(1). PMID: 33446657    Free PMC article.
Metabolic Reprogramming of Cancer Cells during Tumor Progression and Metastasis.
Kenji Ohshima, Eiichi Morii.
Metabolites, 2021 Jan 07; 11(1). PMID: 33401771    Free PMC article.
Review.
Tumor-Associated Antigen xCT and Mutant-p53 as Molecular Targets for New Combinatorial Antitumor Strategies.
Jolanda Magri, Alessandro Gasparetto, +5 authors, Federica Cavallo.
Cells, 2021 Jan 13; 10(1). PMID: 33430127    Free PMC article.
Review.
Recent Discoveries of Macromolecule- and Cell-Based Biomarkers and Therapeutic Implications in Breast Cancer.
Hsing-Ju Wu, Pei-Yi Chu.
Int J Mol Sci, 2021 Jan 14; 22(2). PMID: 33435254    Free PMC article.
Review.
Identification of a Novel Glycolysis-Related Gene Signature for Predicting Breast Cancer Survival.
Dai Zhang, Yi Zheng, +10 authors, Zhijun Dai.
Front Oncol, 2021 Jan 26; 10. PMID: 33489894    Free PMC article.
Upregulation of Antioxidant Capacity and Nucleotide Precursor Availability Suffices for Oncogenic Transformation.
Yang Zhang, Yi Xu, +5 authors, Xiaolu Yang.
Cell Metab, 2020 Nov 08; 33(1). PMID: 33159852    Free PMC article.
Amino Acid Degrading Enzymes and Autophagy in Cancer Therapy.
Ziyu Wang, Qinghong Xie, +3 authors, Dianwen Ju.
Front Pharmacol, 2021 Jan 30; 11. PMID: 33510635    Free PMC article.
Review.
Metabolism of Amino Acids in Cancer.
Zhen Wei, Xiaoyi Liu, +2 authors, Ping Yi.
Front Cell Dev Biol, 2021 Jan 30; 8. PMID: 33511116    Free PMC article.
Review.
LINC00242/miR-1-3p/G6PD axis regulates Warburg effect and affects gastric cancer proliferation and apoptosis.
Peng Deng, Kai Li, +4 authors, Bin Hou.
Mol Med, 2021 Jan 31; 27(1). PMID: 33514309    Free PMC article.
FOXC1 promotes HCC proliferation and metastasis by Upregulating DNMT3B to induce DNA Hypermethylation of CTH promoter.
Zhuoying Lin, Wenjie Huang, +11 authors, Limin Xia.
J Exp Clin Cancer Res, 2021 Feb 02; 40(1). PMID: 33522955    Free PMC article.
Unlocking the Mystery of the Therapeutic Effects of Chinese Medicine on Cancer.
Shao-Hsiang Liu, Po-Sheng Chen, +5 authors, Alan Yueh-Luen Lee.
Front Pharmacol, 2021 Feb 02; 11. PMID: 33519464    Free PMC article.
Mitochondrial Dysfunction, Macrophage, and Microglia in Brain Cancer.
Rongze Olivia Lu, Winson S Ho.
Front Cell Dev Biol, 2021 Feb 02; 8. PMID: 33520994    Free PMC article.
A programmable polymer library that enables the construction of stimuli-responsive nanocarriers containing logic gates.
Penghui Zhang, Di Gao, +15 authors, Weihong Tan.
Nat Chem, 2020 Mar 11; 12(4). PMID: 32152477
Role of Antizyme Inhibitor Proteins in Cancers and Beyond.
Vennela Tulluri, Venkatesh V Nemmara.
Onco Targets Ther, 2021 Feb 04; 14. PMID: 33531815    Free PMC article.
Review.
Tumor Cells and Cancer-Associated Fibroblasts: An Updated Metabolic Perspective.
Géraldine Gentric, Fatima Mechta-Grigoriou.
Cancers (Basel), 2021 Jan 28; 13(3). PMID: 33499022    Free PMC article.
Review.
Raltitrexed-Modified Gold and Silver Nanoparticles for Targeted Cancer Therapy: Cytotoxicity Behavior In Vitro on A549 and HCT-116 Human Cancer Cells.
Jeroni Morey, Pere Llinás, +2 authors, M Nieves Piña.
Materials (Basel), 2021 Jan 28; 14(3). PMID: 33499297    Free PMC article.
GEM-Based Metabolic Profiling for Human Bone Osteosarcoma under Different Glucose and Glutamine Availability.
Ewelina Weglarz-Tomczak, Demi J Rijlaarsdam, Jakub M Tomczak, Stanley Brul.
Int J Mol Sci, 2021 Feb 06; 22(3). PMID: 33540580    Free PMC article.
Flexibility and Adaptation of Cancer Cells in a Heterogenous Metabolic Microenvironment.
Gabriele Grasmann, Ayusi Mondal, Katharina Leithner.
Int J Mol Sci, 2021 Feb 06; 22(3). PMID: 33540663    Free PMC article.
Review.
APC loss induces Warburg effect via increased PKM2 transcription in colorectal cancer.
Pu-Hyeon Cha, Jeong-Ha Hwang, +3 authors, Kang-Yell Choi.
Br J Cancer, 2020 Oct 20; 124(3). PMID: 33071283    Free PMC article.
Human de novo purine biosynthesis.
Vidhi Pareek, Anthony M Pedley, Stephen J Benkovic.
Crit Rev Biochem Mol Biol, 2020 Nov 13; 56(1). PMID: 33179964    Free PMC article.
ATP synthase c-subunit ring as the channel of mitochondrial permeability transition: Regulator of metabolism in development and degeneration.
Nelli Mnatsakanyan, Elizabeth Ann Jonas.
J Mol Cell Cardiol, 2020 May 29; 144. PMID: 32461058    Free PMC article.
CD90 affects the biological behavior and energy metabolism level of gastric cancer cells by targeting the PI3K/AKT/HIF-1α signaling pathway.
Lu Gao, Jun Li, +6 authors, Yanhong Zhou.
Oncol Lett, 2021 Feb 13; 21(3). PMID: 33574930    Free PMC article.
NOTCH1-driven UBR7 stimulates nucleotide biosynthesis to promote T cell acute lymphoblastic leukemia.
Shashank Srivastava, Umakant Sahu, +10 authors, Daniel R Foltz.
Sci Adv, 2021 Feb 12; 7(5). PMID: 33571115    Free PMC article.
Drug Resistance in Glioblastoma: The Two Faces of Oxidative Stress.
Christophe Olivier, Lisa Oliver, Lisenn Lalier, François M Vallette.
Front Mol Biosci, 2021 Feb 16; 7. PMID: 33585565    Free PMC article.
Review.
Salmonella Typhimurium reprograms macrophage metabolism via T3SS effector SopE2 to promote intracellular replication and virulence.
Lingyan Jiang, Peisheng Wang, +14 authors, Lei Wang.
Nat Commun, 2021 Feb 11; 12(1). PMID: 33563986    Free PMC article.
Spatial Lipidomics Reveals Anticancer Mechanisms of Bufalin in Combination with Cinobufagin in Tumor-Bearing Mice.
Jinghui Zhang, Yanjun Hong, +9 authors, Zongwei Cai.
Front Pharmacol, 2021 Feb 19; 11. PMID: 33597874    Free PMC article.
Neural signaling modulates metabolism of gastric cancer.
Hanne-Line Rabben, Gøran Troseth Andersen, +8 authors, Chun-Mei Zhao.
iScience, 2021 Feb 19; 24(2). PMID: 33598644    Free PMC article.
Aquaporin-7 Regulates the Response to Cellular Stress in Breast Cancer.
Chen Dai, Verodia Charlestin, +8 authors, Laurie E Littlepage.
Cancer Res, 2020 Jul 08; 80(19). PMID: 32631905    Free PMC article.
Regulation of Hepatic Metabolism and Cell Growth by the ATF/CREB Family of Transcription Factors.
Aoyuan Cui, Dong Ding, Yu Li.
Diabetes, 2021 Feb 21; 70(3). PMID: 33608424    Free PMC article.
Phase II study of liposomal doxorubicin, docetaxel and trastuzumab in combination with metformin as neoadjuvant therapy for HER2-positive breast cancer.
Andrea Rocca, Pietro Cortesi, +18 authors, Anna Fedeli.
Ther Adv Med Oncol, 2021 Feb 23; 13. PMID: 33613693    Free PMC article.
Mutant p53 as a Regulator and Target of Autophagy.
Yong Shi, Erik Norberg, Helin Vakifahmetoglu-Norberg.
Front Oncol, 2021 Feb 23; 10. PMID: 33614491    Free PMC article.
Review.
Renal metabolism and hypertension.
Zhongmin Tian, Mingyu Liang.
Nat Commun, 2021 Feb 13; 12(1). PMID: 33574248    Free PMC article.
Review.
Serine, glycine and one‑carbon metabolism in cancer (Review).
Sijing Pan, Ming Fan, +2 authors, Huijuan Wang.
Int J Oncol, 2021 Jan 26; 58(2). PMID: 33491748    Free PMC article.
Metabolic Control of m6A RNA Modification.
Joohwan Kim, Gina Lee.
Metabolites, 2021 Feb 13; 11(2). PMID: 33573224    Free PMC article.
Review.
Distinguishable Prognostic miRNA Signatures of Head and Neck Squamous Cell Cancer With or Without HPV Infection.
Xiao-Jie Luo, Min Zheng, +5 authors, Xin-Hua Liang.
Front Oncol, 2021 Mar 02; 10. PMID: 33643915    Free PMC article.
Folic acid supplementation acts as a chemopreventive factor in tumorigenesis of hepatocellular carcinoma by inducing H3K9Me2-dependent transcriptional repression of LCN2.
Yin-Ling Zhang, Geng Xue, +3 authors, Yi Zhang.
Oncotarget, 2021 Mar 05; 12(4). PMID: 33659047    Free PMC article.
R-2-hydroxyglutarate attenuates aerobic glycolysis in leukemia by targeting the FTO/m6A/PFKP/LDHB axis.
Ying Qing, Lei Dong, +26 authors, Jianjun Chen.
Mol Cell, 2021 Jan 13; 81(5). PMID: 33434505    Free PMC article.
ERK and mTORC1 Inhibitors Enhance the Anti-Cancer Capacity of the Octpep-1 Venom-Derived Peptide in Melanoma BRAF(V600E) Mutations.
Javier Moral-Sanz, Manuel A Fernandez-Rojo, +11 authors, Maria P Ikonomopoulou.
Toxins (Basel), 2021 Mar 07; 13(2). PMID: 33672955    Free PMC article.
Novel Regulators of the IGF System in Cancer.
Caterina Mancarella, Andrea Morrione, Katia Scotlandi.
Biomolecules, 2021 Mar 07; 11(2). PMID: 33673232    Free PMC article.
Review.
Signaling pathways in intestinal homeostasis and colorectal cancer: KRAS at centre stage.
Camille Ternet, Christina Kiel.
Cell Commun Signal, 2021 Mar 12; 19(1). PMID: 33691728    Free PMC article.
Review.
Healthy lifestyle and cancer risk among Chinese population in the Dongfeng-Tongji cohort.
Yangting He, Yansen Bai, +13 authors, Li Liu.
Ann Med, 2020 Jul 21; 52(7). PMID: 32683897    Free PMC article.
Targeting Energy Metabolism in Cancer Stem Cells: Progress and Challenges in Leukemia and Solid Tumors.
Courtney L Jones, Anagha Inguva, Craig T Jordan.
Cell Stem Cell, 2021 Mar 06; 28(3). PMID: 33667359    Free PMC article.
Review.
High expression of aldolase A is associated with tumor progression and poor prognosis in hepatocellular carcinoma.
Yan Tang, Xuefeng Yang, +2 authors, Suyi Li.
J Gastrointest Oncol, 2021 Mar 13; 12(1). PMID: 33708434    Free PMC article.
Prognostic Signatures of Metabolic Genes and Metabolism-Related Long Non-coding RNAs Accurately Predict Overall Survival for Osteosarcoma Patients.
Gong Chao-Yang, Tang Rong, +4 authors, Zhang Hai-Hong.
Front Cell Dev Biol, 2021 Mar 13; 9. PMID: 33708772    Free PMC article.
Targeting Mitochondrial Metabolism in Prostate Cancer with Triterpenoids.
Kenza Mamouni, Georgios Kallifatidis, Bal L Lokeshwar.
Int J Mol Sci, 2021 Mar 07; 22(5). PMID: 33671107    Free PMC article.
Review.
Acquired Deficiency of Peroxisomal Dicarboxylic Acid Catabolism is a Metabolic Vulnerability in Hepatoblastoma.
Huabo Wang, Jie Lu, +8 authors, Edward V Prochownik.
J Biol Chem, 2021 Jan 16;. PMID: 33450224    Free PMC article.
Metabolic supervision by PPIP5K, an inositol pyrophosphate kinase/phosphatase, controls proliferation of the HCT116 tumor cell line.
Chunfang Gu, Juan Liu, +5 authors, Stephen B Shears.
Proc Natl Acad Sci U S A, 2021 Mar 03; 118(10). PMID: 33649228    Free PMC article.
Tumor-derived ILT4 induces T cell senescence and suppresses tumor immunity.
Aiqin Gao, Xia Liu, +7 authors, Guangyong Peng.
J Immunother Cancer, 2021 Mar 04; 9(3). PMID: 33653799    Free PMC article.
18F-fluorodeoxyglucose positron emission tomography correlates with tumor immunometabolic phenotypes in resected lung cancer.
Kyle G Mitchell, Behrang Amini, +25 authors, Tina Cascone.
Cancer Immunol Immunother, 2020 Apr 18; 69(8). PMID: 32300858    Free PMC article.
The deubiquitinase JOSD2 is a positive regulator of glucose metabolism.
Lyudmila Krassikova, Boxi Zhang, +5 authors, Erik Norberg.
Cell Death Differ, 2020 Oct 22; 28(3). PMID: 33082514    Free PMC article.
Transient phases of OXPHOS inhibitor resistance reveal underlying metabolic heterogeneity in single cells.
Nont Kosaisawe, Breanne Sparta, +2 authors, John G Albeck.
Cell Metab, 2021 Feb 10; 33(3). PMID: 33561427    Free PMC article.
Serum Metabolic Profiling Analysis of Chronic Gastritis and Gastric Cancer by Untargeted Metabolomics.
Lin Yu, Qinhuai Lai, +3 authors, Bei Xu.
Front Oncol, 2021 Mar 30; 11. PMID: 33777793    Free PMC article.
Metabolomic Signatures of Autoimmune Hepatitis in the Development of Cirrhosis.
Shan-Shan Li, Ming Niu, +10 authors, Jia-Bo Wang.
Front Med (Lausanne), 2021 Mar 30; 8. PMID: 33777984    Free PMC article.
Warburg-like Metabolic Reprogramming in Aging Intestinal Stem Cells Contributes to Tissue Hyperplasia.
Otto Morris, Hansong Deng, Christine Tam, Heinrich Jasper.
Cell Rep, 2020 Nov 26; 33(8). PMID: 33238124    Free PMC article.
Interpretation of the absorbed constituents and pharmacological effect of Spica Schizonepetae extract on non-small cell lung cancer.
Shuai Wang, Xinxin Yang, +5 authors, Xiansheng Meng.
PLoS One, 2021 Mar 18; 16(3). PMID: 33730076    Free PMC article.
Mitochondrial metabolism supports resistance to IDH mutant inhibitors in acute myeloid leukemia.
Lucille Stuani, Marie Sabatier, +50 authors, Jean-Emmanuel Sarry.
J Exp Med, 2021 Mar 25; 218(5). PMID: 33760042    Free PMC article.
BMP4 augments the survival of hepatocellular carcinoma (HCC) cells under hypoxia and hypoglycemia conditions by promoting the glycolysis pathway.
Jiamin Zhong, Quan Kang, +6 authors, Jiaming Fan.
Am J Cancer Res, 2021 Apr 02; 11(3). PMID: 33791154    Free PMC article.
Construction of Prognostic Risk Prediction Model of Oral Squamous Cell Carcinoma Based on Nine Survival-Associated Metabolic Genes.
Zhen-Dong Huang, Yang-Yang Yao, +3 authors, Yu-Ming Niu.
Front Physiol, 2021 Apr 06; 12. PMID: 33815132    Free PMC article.
Shifting the Gears of Metabolic Plasticity to Drive Cell State Transitions in Cancer.
Zhengwei Wu, Yi Fei Lee, +2 authors, Wai Leong Tam.
Cancers (Basel), 2021 Apr 04; 13(6). PMID: 33804114    Free PMC article.
Review.
Comparing Metabolomics Profiles in Various Types of Liquid Biopsies among Screening Participants with and without Advanced Colorectal Neoplasms.
Vanessa Erben, Gernot Poschet, Petra Schrotz-King, Hermann Brenner.
Diagnostics (Basel), 2021 Apr 04; 11(3). PMID: 33804777    Free PMC article.
A Novel Therapeutic Target, BACH1, Regulates Cancer Metabolism.
Joselyn Padilla, Jiyoung Lee.
Cells, 2021 Apr 04; 10(3). PMID: 33809182    Free PMC article.
Review.
Metabolism of immune cells in cancer.
Robert D Leone, Jonathan D Powell.
Nat Rev Cancer, 2020 Jul 08; 20(9). PMID: 32632251    Free PMC article.
Review.
High expression of NEK2 promotes gastric cancer progression via activating AKT signaling.
Hao Wan, Lin Xu, +3 authors, Taiyuan Li.
J Physiol Biochem, 2020 Nov 18; 77(1). PMID: 33201407
Role of kynurenine in promoting the generation of exhausted CD8+ T cells in colorectal cancer.
Dandan Wu, Yufeng Zhu.
Am J Transl Res, 2021 Apr 13; 13(3). PMID: 33841677    Free PMC article.
A novel metabolic gene signature-based nomogram to predict overall survival in breast cancer.
Xi Sun, Zhi-Rui Zhou, +6 authors, Kunwei Shen.
Ann Transl Med, 2021 Apr 13; 9(5). PMID: 33842588    Free PMC article.
c-MYC-directed NRF2 drives malignant progression of head and neck cancer via glucose-6-phosphate dehydrogenase and transketolase activation.
Ya-Chu Tang, Jenn-Ren Hsiao, +12 authors, Ching-Chuan Kuo.
Theranostics, 2021 Apr 17; 11(11). PMID: 33859744    Free PMC article.
The Metabolic Landscape of RAS-Driven Cancers from biology to therapy.
Suman Mukhopadhyay, Matthew G Vander Heiden, Frank McCormick.
Nat Cancer, 2021 Apr 20; 2(3). PMID: 33870211    Free PMC article.
The evolving metabolic landscape of chromatin biology and epigenetics.
Ziwei Dai, Vijyendra Ramesh, Jason W Locasale.
Nat Rev Genet, 2020 Sep 11; 21(12). PMID: 32908249    Free PMC article.
Review.
Simultaneous Integration of Gene Expression and Nutrient Availability for Studying the Metabolism of Hepatocellular Carcinoma Cell Lines.
Ewelina Weglarz-Tomczak, Thierry D G A Mondeel, Diewertje G E Piebes, Hans V Westerhoff.
Biomolecules, 2021 Apr 04; 11(4). PMID: 33805227    Free PMC article.
An expanded universe of cancer targets.
William C Hahn, Joel S Bader, +21 authors, Cancer Target Discovery and Development Network.
Cell, 2021 Mar 06; 184(5). PMID: 33667368    Free PMC article.
Review.
Proteogenomic Landscape of Breast Cancer Tumorigenesis and Targeted Therapy.
Karsten Krug, Eric J Jaehnig, +44 authors, Clinical Proteomic Tumor Analysis Consortium.
Cell, 2020 Nov 20; 183(5). PMID: 33212010    Free PMC article.
Succinate Anaplerosis Has an Onco-Driving Potential in Prostate Cancer Cells.
Ana Carolina B Sant'Anna-Silva, Juan A Perez-Valencia, +9 authors, Helmut Klocker.
Cancers (Basel), 2021 May 01; 13(7). PMID: 33917317    Free PMC article.
Metabolites and the tumour microenvironment: from cellular mechanisms to systemic metabolism.
Ilaria Elia, Marcia C Haigis.
Nat Metab, 2021 Jan 06; 3(1). PMID: 33398194    Free PMC article.
Review.
Metabolic implications of non-electrogenic ATP/ADP exchange in cancer cells: A mechanistic basis for the Warburg effect.
John J Lemasters.
Biochim Biophys Acta Bioenerg, 2021 Mar 17; 1862(7). PMID: 33722515    Free PMC article.
Review.
HIF1α-dependent induction of the mitochondrial chaperone TRAP1 regulates bioenergetic adaptations to hypoxia.
Claudio Laquatra, Carlos Sanchez-Martin, +10 authors, Andrea Rasola.
Cell Death Dis, 2021 May 03; 12(5). PMID: 33934112    Free PMC article.
Targeting SLC1A5 and SLC3A2/SLC7A5 as a Potential Strategy to Strengthen Anti-Tumor Immunity in the Tumor Microenvironment.
Marianna Nachef, Alaa Kassim Ali, Saeedah Musaed Almutairi, Seung-Hwan Lee.
Front Immunol, 2021 May 07; 12. PMID: 33953707    Free PMC article.
Review.
How do cancer cells replenish their fuel supply?
Abdallah K Alameddine, Frederick T Conlin, +2 authors, Khaled O Alameddine.
Cancer Rep (Hoboken), 2018 Jun 01; 1(1). PMID: 32729259    Free PMC article.
Review.
Reclaiming Warburg: using developmental biology to gain insight into human metabolic diseases.
Daniela Drummond-Barbosa, Jason M Tennessen.
Development, 2020 Jun 17; 147(11). PMID: 32540896    Free PMC article.
Effect of hypoxia factors gene silencing on ROS production and metabolic status of A375 malignant melanoma cells.
Ivana Špaková, Miroslava Rabajdová, +2 authors, Mária Mareková.
Sci Rep, 2021 May 16; 11(1). PMID: 33990669    Free PMC article.
Cell-programmed nutrient partitioning in the tumour microenvironment.
Bradley I Reinfeld, Matthew Z Madden, +29 authors, W Kimryn Rathmell.
Nature, 2021 Apr 09; 593(7858). PMID: 33828302    Free PMC article.
Hexokinase 2 in Cancer: A Prima Donna Playing Multiple Characters.
Francesco Ciscato, Lavinia Ferrone, +2 authors, Andrea Rasola.
Int J Mol Sci, 2021 May 06; 22(9). PMID: 33946854    Free PMC article.
Review.
Mitochondrial metabolism-mediated redox regulation in cancer progression.
Austin C Boese, Sumin Kang.
Redox Biol, 2021 Jan 30; 42. PMID: 33509708    Free PMC article.
Aldolase A Enhances Intrahepatic Cholangiocarcinoma Proliferation and Invasion through Promoting Glycolysis.
Xiang Li, Chang Yu, +7 authors, Xiaoni Kong.
Int J Biol Sci, 2021 May 18; 17(7). PMID: 33994862    Free PMC article.
Profiling Ribonucleotide and Deoxyribonucleotide Pools Perturbed by Remdesivir in Human Bronchial Epithelial Cells.
Yan Li, Hui-Xia Zhang, +6 authors, Zhi-Hong Jiang.
Front Pharmacol, 2021 May 18; 12. PMID: 33995062    Free PMC article.
Conspicuous and frank dilated vascular spaces: A marker of malignant transformation in oral submucous fibrosis.
Sachin C Sarode, Gargi S Sarode, +2 authors, Shankargouda Patil.
J Oral Biol Craniofac Res, 2021 May 18; 11(3). PMID: 33996430    Free PMC article.
Identification of an Individualized Metabolism Prognostic Signature and Related Therapy Regimens in Early Stage Lung Adenocarcinoma.
Junjie Hu, Huansha Yu, +4 authors, Peng Zhang.
Front Oncol, 2021 May 18; 11. PMID: 33996569    Free PMC article.
Advances in cancer cachexia: Intersection between affected organs, mediators, and pharmacological interventions.
Jawed A Siddiqui, Ramesh Pothuraju, +2 authors, Mohd W Nasser.
Biochim Biophys Acta Rev Cancer, 2020 Mar 31; 1873(2). PMID: 32222610    Free PMC article.
Review.
Altered Mitochondria Functionality Defines a Metastatic Cell State in Lung Cancer and Creates an Exploitable Vulnerability.
Chen-Hua Chuang, Madeleine Dorsch, +6 authors, Barbara M Grüner.
Cancer Res, 2020 Nov 27; 81(3). PMID: 33239425    Free PMC article.
mTORC1 stimulates cell growth through SAM synthesis and m6A mRNA-dependent control of protein synthesis.
Elodie Villa, Umakant Sahu, +6 authors, Issam Ben-Sahra.
Mol Cell, 2021 Mar 24; 81(10). PMID: 33756106    Free PMC article.
Emerging roles of nucleotide metabolism in cancer development: progress and prospect.
Jingsong Ma, Mengya Zhong, +4 authors, Xuehui Hong.
Aging (Albany NY), 2021 May 07; 13(9). PMID: 33952722    Free PMC article.
Mitochondrial pyruvate carrier 1: a novel prognostic biomarker that predicts favourable patient survival in cancer.
Chen Xue, Ganglei Li, +2 authors, Lanjuan Li.
Cancer Cell Int, 2021 Jun 02; 21(1). PMID: 34059057    Free PMC article.
Review.
Enhanced triacylglycerol catabolism by carboxylesterase 1 promotes aggressive colorectal carcinoma.
Daria Capece, Daniel D'Andrea, +24 authors, Guido Franzoso.
J Clin Invest, 2021 Apr 21; 131(11). PMID: 33878036    Free PMC article.
More Than Meets the Eye: Scientific Rationale behind Molecular Imaging and Therapeutic Targeting of Prostate-Specific Membrane Antigen (PSMA) in Metastatic Prostate Cancer and Beyond.
Anniina Hyväkkä, Verneri Virtanen, +3 authors, Maria Sundvall.
Cancers (Basel), 2021 Jun 03; 13(9). PMID: 34067046    Free PMC article.
Review.
Deregulated FASN Expression in BRAF Inhibitor-Resistant Melanoma Cells Unveils New Targets for Drug Combinations.
Serena Stamatakos, Giovanni Luca Beretta, +9 authors, Laura Gatti.
Cancers (Basel), 2021 Jun 03; 13(9). PMID: 34068792    Free PMC article.