Review
. 2017 Feb; 22:1221-1246.
doi: 10.2741/4543.

Racial disparity in metabolic regulation of cancer

Kuldeep S Attri 1 Divya Murthy 1 Pankaj K Singh 2 
Affiliations
  • PMID: 28199202
  •     191 References
  •     3 citations

Abstract

Genetic mutations and metabolic reprogramming are two key hallmarks of cancer, required for proliferation, invasion, and metastasis of the disease. While genetic mutations, whether inherited or acquired, are critical for the initiation of tumor development, metabolic reprogramming is an effector mechanism imperative for adaptational transition during the progression of cancer. Recent findings in the literature emphasize the significance of molecular cross-talk between these two cellular processes in regulating signaling and differentiation of cancer cells. Genome-wide sequencing analyses of cancer genomes have highlighted the association of various genic mutations in predicting cancer risk and survival. Oncogenic mutational frequency is heterogeneously distributed among various cancer types in different populations, resulting in varying susceptibility to cancer risk. In this review, we explore and discuss the role of genetic mutations in metabolic enzymes and metabolic oncoregulators to stratify cancer risk in persons of different racial backgrounds.

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Cancer pharmacogenomics: powerful tools in cancer chemotherapy and drug development.
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Cancer Res, 2002 Oct 18; 62(20). PMID: 12384552
Metabolites of the Polycyclic Aromatic Hydrocarbon Phenanthrene in the Urine of Cigarette Smokers from Five Ethnic Groups with Differing Risks for Lung Cancer.
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BMC Cancer, 2014 Feb 06; 14. PMID: 24495414    Free PMC article.
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Caitlin C Murphy, Christopher F Martin, Robert S Sandler.
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Pancreas, 2002 Dec 25; 26(1). PMID: 12499914
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Oncogenic activation of the PI3K/Akt pathway promotes cellular glucose uptake by downregulating the expression of thioredoxin-interacting protein.
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Cell Signal, 2016 Jan 31; 28(5). PMID: 26826652
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Lactate: a metabolic key player in cancer.
Franziska Hirschhaeuser, Ulrike G A Sattler, Wolfgang Mueller-Klieser.
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J Endocrinol, 2004 Nov 05; 183(1). PMID: 15525582
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Genetic variations in genes of metabolic enzymes predict postoperational prognosis of patients with colorectal cancer.
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MYC-induced cancer cell energy metabolism and therapeutic opportunities.
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Y Wang, A Helland, +6 authors, G B Kristensen.
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Cell Cycle, 2009 Nov 20; 8(23). PMID: 19923890
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Common haplotypes of the C-reactive protein gene and circulating leptin levels influence the interindividual variability in serum C-reactive protein levels. The Segovia study.
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Racial disparities in colorectal cancer incidence by type 2 diabetes mellitus status.
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Colorectal cancers from distinct ancestral populations show variations in BRAF mutation frequency.
Megan C Hanna, Christina Go, +18 authors, Laura E MacConaill.
PLoS One, 2013 Sep 26; 8(9). PMID: 24066160    Free PMC article.
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Metabolic characterization of triple negative breast cancer.
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BMC Cancer, 2014 Dec 17; 14. PMID: 25495193    Free PMC article.
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Mol Cell, 2014 Dec 03; 56(3). PMID: 25458842    Free PMC article.
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Genome-wide association studies and Crohn's disease.
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Ethnic and racial differences in the smoking-related risk of lung cancer.
Christopher A Haiman, Daniel O Stram, +4 authors, Loïc Le Marchand.
N Engl J Med, 2006 Jan 27; 354(4). PMID: 16436765
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Associations of dietary folate, Vitamins B6 and B12 and methionine intake with risk of breast cancer among African American and European American women.
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Highly Cited. Review.
Glucose transporters in cancer metabolism.
Kehinde Adekola, Steven T Rosen, Mala Shanmugam.
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Highly Cited. Review.
De Novo Lipid Synthesis Facilitates Gemcitabine Resistance through Endoplasmic Reticulum Stress in Pancreatic Cancer.
Saber Tadros, Surendra K Shukla, +10 authors, Pankaj K Singh.
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Ancestry-associated transcriptomic profiles of breast cancer in patients of African, Arab, and European ancestry.
Jessica Roelands, Raghvendra Mall, +11 authors, Julie Decock.
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