Journal Article
. 2017 Mar; 9(379):.
doi: 10.1126/scitranslmed.aah3560.

Integrated molecular analysis of tumor biopsies on sequential CTLA-4 and PD-1 blockade reveals markers of response and resistance

Whijae Roh 1 Pei-Ling Chen 1 Alexandre Reuben 2 Christine N Spencer 1 Peter A Prieto 2 John P Miller 3 Vancheswaran Gopalakrishnan 2 Feng Wang 1 Zachary A Cooper 1 Sangeetha M Reddy 4 Curtis Gumbs 1 Latasha Little 1 Qing Chang 1 Wei-Shen Chen 1 Khalida Wani 5 Mariana Petaccia De Macedo 5 Eveline Chen 5 Jacob L Austin-Breneman 2 Hong Jiang 2 Jason Roszik 1 Michael T Tetzlaff 6 Michael A Davies 7 Jeffrey E Gershenwald 2 Hussein Tawbi 7 Alexander J Lazar 2 Patrick Hwu 7 Wen-Jen Hwu 7 Adi Diab 7 Isabella C Glitza 7 Sapna P Patel 7 Scott E Woodman 7 Rodabe N Amaria 7 Victor G Prieto 6 Jianhua Hu 8 Padmanee Sharma 9 James P Allison 9 Lynda Chin 10 Jianhua Zhang 11 Jennifer A Wargo 12 P Andrew Futreal 12 
Affiliations
  • PMID: 28251903
  •     68 References
  •     301 citations

Abstract

Immune checkpoint blockade produces clinical benefit in many patients. However, better biomarkers of response are still needed, and mechanisms of resistance remain incompletely understood. To address this, we recently studied a cohort of melanoma patients treated with sequential checkpoint blockade against cytotoxic T lymphocyte antigen-4 (CTLA-4) followed by programmed death receptor-1 (PD-1) and identified immune markers of response and resistance. Building on these studies, we performed deep molecular profiling including T cell receptor sequencing and whole-exome sequencing within the same cohort and demonstrated that a more clonal T cell repertoire was predictive of response to PD-1 but not CTLA-4 blockade. Analysis of CNAs identified a higher burden of copy number loss in nonresponders to CTLA-4 and PD-1 blockade and found that it was associated with decreased expression of genes in immune-related pathways. The effect of mutational load and burden of copy number loss on response was nonredundant, suggesting the potential utility of a combinatorial biomarker to optimize patient care with checkpoint blockade therapy.

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A mathematical modelling tool for unravelling the antibody-mediated effects on CTLA-4 interactions.
Aravindhan Ganesan, Theinmozhi Arulraj, Tahir Choulli, Khaled H Barakat.
BMC Med Inform Decis Mak, 2018 Jun 13; 18(1). PMID: 29890992    Free PMC article.
Melanoma Immunotherapy: Next-Generation Biomarkers.
Sabrina A Hogan, Mitchell P Levesque, Phil F Cheng.
Front Oncol, 2018 Jun 14; 8. PMID: 29896449    Free PMC article.
Review.
Tumor matrix remodeling and novel immunotherapies: the promise of matrix-derived immune biomarkers.
Muhammad Umair Mushtaq, Athanasios Papadas, +4 authors, Fotis Asimakopoulos.
J Immunother Cancer, 2018 Jul 05; 6(1). PMID: 29970158    Free PMC article.
Review.
The association of genomic lesions and PD-1/PD-L1 expression in resected triple-negative breast cancers.
Michael T Barrett, Elizabeth Lenkiewicz, +10 authors, Barbara A Pockaj.
Breast Cancer Res, 2018 Jul 13; 20(1). PMID: 29996881    Free PMC article.
Microbial biomarkers for immune checkpoint blockade therapy against cancer.
Keishi Adachi, Koji Tamada.
J Gastroenterol, 2018 Jul 14; 53(9). PMID: 30003334    Free PMC article.
Review.
Immune Profiling of Cancer Patients Treated with Immunotherapy: Advances and Challenges.
Lorenzo Pilla, Cristina Maccalli.
Biomedicines, 2018 Jul 14; 6(3). PMID: 30004433    Free PMC article.
Review.
Distinct immune signatures in directly treated and distant tumors result from TLR adjuvants and focal ablation.
Michael Chavez, Matthew T Silvestrini, +11 authors, Katherine W Ferrara.
Theranostics, 2018 Jul 22; 8(13). PMID: 30026870    Free PMC article.
Urea Cycle Dysregulation Generates Clinically Relevant Genomic and Biochemical Signatures.
Joo Sang Lee, Lital Adler, +31 authors, Ayelet Erez.
Cell, 2018 Aug 14; 174(6). PMID: 30100185    Free PMC article.
Pan-cancer deconvolution of tumour composition using DNA methylation.
Ankur Chakravarthy, Andrew Furness, +10 authors, Tim R Fenton.
Nat Commun, 2018 Aug 15; 9(1). PMID: 30104673    Free PMC article.
Future prospects of immune checkpoint blockade in cancer: from response prediction to overcoming resistance.
Young-Jun Park, Da-Sol Kuen, Yeonseok Chung.
Exp Mol Med, 2018 Aug 24; 50(8). PMID: 30135516    Free PMC article.
Highly Cited. Review.
Genomic correlates of response to immune checkpoint blockade in microsatellite-stable solid tumors.
Diana Miao, Claire A Margolis, +28 authors, Eliezer M Van Allen.
Nat Genet, 2018 Aug 29; 50(9). PMID: 30150660    Free PMC article.
Highly Cited.
T Cell-Inflamed versus Non-T Cell-Inflamed Tumors: A Conceptual Framework for Cancer Immunotherapy Drug Development and Combination Therapy Selection.
Jonathan A Trujillo, Randy F Sweis, Riyue Bao, Jason J Luke.
Cancer Immunol Res, 2018 Sep 06; 6(9). PMID: 30181337    Free PMC article.
Highly Cited.
[Molecular predictors in immune oncology].
W Weichert.
Pathologe, 2018 Sep 15; 39(6). PMID: 30215118
Review.
Phase II study of neoadjuvant checkpoint blockade in patients with surgically resectable undifferentiated pleomorphic sarcoma and dedifferentiated liposarcoma.
Emily Z Keung, Alexander J Lazar, +12 authors, Christina L Roland.
BMC Cancer, 2018 Sep 27; 18(1). PMID: 30249211    Free PMC article.
The DNA damage response in immunotherapy and radiation.
Robert M Samstein, Nadeem Riaz.
Adv Radiat Oncol, 2018 Oct 30; 3(4). PMID: 30370352    Free PMC article.
Review.
TCR Repertoire as a Novel Indicator for Immune Monitoring and Prognosis Assessment of Patients With Cervical Cancer.
Jin-Huan Cui, Kai-Rong Lin, +8 authors, Wei Luo.
Front Immunol, 2018 Dec 14; 9. PMID: 30524447    Free PMC article.
Biomarkers, measured during therapy, for response of melanoma patients to immune checkpoint inhibitors: a systematic review.
Wouter Ouwerkerk, Mirjam van den Berg, +2 authors, Rosalie M Luiten.
Melanoma Res, 2019 Mar 12; 29(5). PMID: 30855527    Free PMC article.
Systematic Review.
PTEN Alterations as a Potential Mechanism for Tumor Cell Escape from PD-1/PD-L1 Inhibition.
Daniele Cretella, Graziana Digiacomo, Elisa Giovannetti, Andrea Cavazzoni.
Cancers (Basel), 2019 Sep 11; 11(9). PMID: 31500143    Free PMC article.
Review.
Immunoglobulin somatic hypermutation has clinical impact in DLBCL and potential implications for immune checkpoint blockade and neoantigen-based immunotherapies.
Zijun Y Xu-Monette, Jianyong Li, +27 authors, Ken H Young.
J Immunother Cancer, 2019 Oct 24; 7(1). PMID: 31640780    Free PMC article.
The impact of CTLA-4 blockade and interferon-α on clonality of T-cell repertoire in the tumor microenvironment and peripheral blood of metastatic melanoma patients.
Arjun Khunger, Julie A Rytlewski, +2 authors, Ahmad A Tarhini.
Oncoimmunology, 2019 Oct 28; 8(11). PMID: 31646098    Free PMC article.
Revising PTEN in the Era of Immunotherapy: New Perspectives for an Old Story.
Geny Piro, Carmine Carbone, +6 authors, Giampaolo Tortora.
Cancers (Basel), 2019 Oct 30; 11(10). PMID: 31658667    Free PMC article.
Review.
The Predictive Value of Tumor Mutation Burden on Efficacy of Immune Checkpoint Inhibitors in Cancers: A Systematic Review and Meta-Analysis.
Yongfeng Wu, Jinming Xu, +4 authors, Jian Hu.
Front Oncol, 2019 Nov 22; 9. PMID: 31750249    Free PMC article.
Systematic Review.
TCR Convergence in Individuals Treated With Immune Checkpoint Inhibition for Cancer.
Timothy John Looney, Denise Topacio-Hall, +5 authors, Li Zhang.
Front Immunol, 2020 Jan 30; 10. PMID: 31993050    Free PMC article.
Identification of Distinct Immune Subtypes in Colorectal Cancer Based on the Stromal Compartment.
Rongfang Shen, Ping Li, +3 authors, Shujun Cheng.
Front Oncol, 2020 Jan 31; 9. PMID: 31998649    Free PMC article.
Comprehensive T cell repertoire characterization of non-small cell lung cancer.
Alexandre Reuben, Jiexin Zhang, +55 authors, Jianjun Zhang.
Nat Commun, 2020 Feb 01; 11(1). PMID: 32001676    Free PMC article.
Is there a causal link between PTEN deficient tumors and immunosuppressive tumor microenvironment?
Vildan B Cetintas, Nizar N Batada.
J Transl Med, 2020 Feb 01; 18(1). PMID: 32000794    Free PMC article.
Review.
Prognostic Biomarkers for Melanoma Immunotherapy.
Christopher G Twitty, Laura A Huppert, Adil I Daud.
Curr Oncol Rep, 2020 Feb 13; 22(3). PMID: 32048065
Review.
Next-Generation Sequencing-Based Assessment of JAK2, PD-L1, and PD-L2 Copy Number Alterations at 9p24.1 in Breast Cancer: Potential Implications for Clinical Management.
Sounak Gupta, Chad M Vanderbilt, +12 authors, Dara S Ross.
J Mol Diagn, 2018 Dec 24; 21(2). PMID: 30576871    Free PMC article.
A model combining clinical and genomic factors to predict response to PD-1/PD-L1 blockade in advanced urothelial carcinoma.
Amin H Nassar, Kent W Mouw, +17 authors, David J Kwiatkowski.
Br J Cancer, 2019 Dec 21; 122(4). PMID: 31857723    Free PMC article.
Genetic and Epigenetic Biomarkers of Immune Checkpoint Blockade Response.
Qingyang Xiao, André Nobre, +5 authors, Isabel Barragán.
J Clin Med, 2020 Jan 24; 9(1). PMID: 31968651    Free PMC article.
Review.
Predicting clinical benefit of immunotherapy by antigenic or functional mutations affecting tumour immunogenicity.
Kwoneel Kim, Hong Sook Kim, +7 authors, Jung Kyoon Choi.
Nat Commun, 2020 Feb 23; 11(1). PMID: 32075964    Free PMC article.
Immuno-genomic landscape of osteosarcoma.
Chia-Chin Wu, Hannah C Beird, +23 authors, P Andrew Futreal.
Nat Commun, 2020 Feb 23; 11(1). PMID: 32081846    Free PMC article.
Biohybrid Vaccines for Improved Treatment of Aggressive Melanoma with Checkpoint Inhibitor.
Flavia Fontana, Manlio Fusciello, +9 authors, Hélder A Santos.
ACS Nano, 2019 May 18; 13(6). PMID: 31100004    Free PMC article.
Immune Checkpoint Ligand PD-L1 Is Upregulated in Pulmonary Lymphangioleiomyomatosis.
Katharina Maisel, Mervyn J Merrilees, +12 authors, Vera P Krymskaya.
Am J Respir Cell Mol Biol, 2018 Aug 11; 59(6). PMID: 30095976    Free PMC article.
Neoadjuvant immune checkpoint blockade in high-risk resectable melanoma.
Rodabe N Amaria, Sangeetha M Reddy, +42 authors, Jennifer A Wargo.
Nat Med, 2018 Oct 10; 24(11). PMID: 30297909    Free PMC article.
Highly Cited.
Melanoma subtypes: genomic profiles, prognostic molecular markers and therapeutic possibilities.
Roy Rabbie, Peter Ferguson, +2 authors, Carla D Robles-Espinoza.
J Pathol, 2018 Dec 05; 247(5). PMID: 30511391    Free PMC article.
Review.
Immune checkpoint inhibitors in MITF family translocation renal cell carcinomas and genetic correlates of exceptional responders.
A Boilève, M I Carlo, +16 authors, Gabriel G Malouf.
J Immunother Cancer, 2018 Dec 29; 6(1). PMID: 30591082    Free PMC article.
TCR Repertoire Analysis Reveals Mobilization of Novel CD8+ T Cell Clones Into the Cancer-Immunity Cycle Following Anti-CD4 Antibody Administration.
Hiroyasu Aoki, Satoshi Ueha, +5 authors, Kouji Matsushima.
Front Immunol, 2019 Feb 09; 9. PMID: 30733724    Free PMC article.
Genomic correlates of response to immune checkpoint blockade.
Tanya E Keenan, Kelly P Burke, Eliezer M Van Allen.
Nat Med, 2019 Mar 08; 25(3). PMID: 30842677    Free PMC article.
Highly Cited. Review.
Model to improve specificity for identification of clinically-relevant expanded T cells in peripheral blood.
Julie Rytlewski, Shibing Deng, +4 authors, Jadwiga Bienkowska.
PLoS One, 2019 Mar 15; 14(3). PMID: 30870493    Free PMC article.
Tumor genomic alterations in severe-combined immunodeficiency bare-lymphocyte syndrome genes are associated with high mutational burden and disproportional neo-antigen rates.
Yu Wang, Douglas B Johnson, +3 authors, Justin M Balko.
J Immunother Cancer, 2019 May 09; 7(1). PMID: 31064401    Free PMC article.
Paired whole exome and transcriptome analyses for the Immunogenomic changes during concurrent chemoradiotherapy in esophageal squamous cell carcinoma.
Sehhoon Park, Je-Gun Joung, +10 authors, Jong-Mu Sun.
J Immunother Cancer, 2019 May 18; 7(1). PMID: 31097034    Free PMC article.
Toward a comprehensive view of cancer immune responsiveness: a synopsis from the SITC workshop.
Davide Bedognetti, Michele Ceccarelli, +53 authors, Society for Immunotherapy of Cancer (SITC) Cancer Immune Responsiveness Task Force and Working Groups.
J Immunother Cancer, 2019 May 23; 7(1). PMID: 31113486    Free PMC article.
Review.
Association of LRP1B Mutation With Tumor Mutation Burden and Outcomes in Melanoma and Non-small Cell Lung Cancer Patients Treated With Immune Check-Point Blockades.
Hao Chen, Wei Chong, +3 authors, Xin Wang.
Front Immunol, 2019 Jun 06; 10. PMID: 31164891    Free PMC article.
DNA methylation loss promotes immune evasion of tumours with high mutation and copy number load.
Hyunchul Jung, Hong Sook Kim, +7 authors, Jung Kyoon Choi.
Nat Commun, 2019 Sep 21; 10(1). PMID: 31537801    Free PMC article.
Metabolomic adaptations and correlates of survival to immune checkpoint blockade.
Haoxin Li, Kevin Bullock, +19 authors, Marios Giannakis.
Nat Commun, 2019 Sep 27; 10(1). PMID: 31554815    Free PMC article.
Integrative molecular and clinical modeling of clinical outcomes to PD1 blockade in patients with metastatic melanoma.
David Liu, Bastian Schilling, +33 authors, Dirk Schadendorf.
Nat Med, 2019 Dec 04; 25(12). PMID: 31792460    Free PMC article.
Highly Cited.
CTLA-4 blockade boosts the expansion of tumor-reactive CD8+ tumor-infiltrating lymphocytes in ovarian cancer.
Christina Friese, Katja Harbst, +7 authors, Özcan Met.
Sci Rep, 2020 Mar 05; 10(1). PMID: 32127601    Free PMC article.
miRNAs as Key Players in the Management of Cutaneous Melanoma.
Celeste Lorusso, Simona De Summa, +2 authors, Stefania Tommasi.
Cells, 2020 Feb 15; 9(2). PMID: 32054078    Free PMC article.
Review.
Burden of tumor mutations, neoepitopes, and other variants are weak predictors of cancer immunotherapy response and overall survival.
Mary A Wood, Benjamin R Weeder, +2 authors, Reid F Thompson.
Genome Med, 2020 Apr 02; 12(1). PMID: 32228719    Free PMC article.
Metabolism-associated molecular classification of hepatocellular carcinoma.
Chen Yang, Xiaowen Huang, +2 authors, Cun Wang.
Mol Oncol, 2020 Jan 20; 14(4). PMID: 31955511    Free PMC article.
Quantitative Mechanistic Modeling in Support of Pharmacological Therapeutics Development in Immuno-Oncology.
Kirill Peskov, Ivan Azarov, +3 authors, Gabriel Helmlinger.
Front Immunol, 2019 May 28; 10. PMID: 31134058    Free PMC article.
Review.
Tumor Microenvironment Characterization in Glioblastoma Identifies Prognostic and Immunotherapeutically Relevant Gene Signatures.
Jinsen Zhang, Xing Xiao, Xin Zhang, Wei Hua.
J Mol Neurosci, 2020 Feb 02; 70(5). PMID: 32006162
An immune relevant signature for predicting prognoses and immunotherapeutic responses in patients with muscle-invasive bladder cancer (MIBC).
Wen Jiang, Dandan Zhu, Chenghe Wang, Yu Zhu.
Cancer Med, 2020 Feb 26; 9(8). PMID: 32096345    Free PMC article.
Sex-associated molecular differences for cancer immunotherapy.
Youqiong Ye, Ying Jing, +4 authors, Leng Han.
Nat Commun, 2020 Apr 15; 11(1). PMID: 32286310    Free PMC article.
Spatially resolved analyses link genomic and immune diversity and reveal unfavorable neutrophil activation in melanoma.
Akash Mitra, Miles C Andrews, +34 authors, P Andrew Futreal.
Nat Commun, 2020 Apr 17; 11(1). PMID: 32296058    Free PMC article.
The Role of the Lymphocyte Functional Crosstalk and Regulation in the Context of Checkpoint Inhibitor Treatment-Review.
Barbara Seliger.
Front Immunol, 2019 Sep 27; 10. PMID: 31555274    Free PMC article.
Review.
Master protocols in immuno-oncology: do novel drugs deserve novel designs?
Luca Mazzarella, Stefania Morganti, +4 authors, Giuseppe Curigliano.
J Immunother Cancer, 2020 Apr 03; 8(1). PMID: 32238471    Free PMC article.
Review.
Molecular T-Cell Repertoire Analysis as Source of Prognostic and Predictive Biomarkers for Checkpoint Blockade Immunotherapy.
Ilenia Aversa, Donatella Malanga, Giuseppe Fiume, Camillo Palmieri.
Int J Mol Sci, 2020 Apr 03; 21(7). PMID: 32235561    Free PMC article.
Review.
RNase H-dependent PCR-enabled T-cell receptor sequencing for highly specific and efficient targeted sequencing of T-cell receptor mRNA for single-cell and repertoire analysis.
Shuqiang Li, Jing Sun, +10 authors, Kenneth J Livak.
Nat Protoc, 2019 Jul 26; 14(8). PMID: 31341290    Free PMC article.
Epigenetic driver mutations in ARID1A shape cancer immune phenotype and immunotherapy.
Jing Li, Weichao Wang, +22 authors, Weiping Zou.
J Clin Invest, 2020 Feb 07; 130(5). PMID: 32027624    Free PMC article.
Immune gene signature delineates a subclass of thyroid cancer with unfavorable clinical outcomes.
Jingtai Zhi, Jiaoyu Yi, +4 authors, Ming Gao.
Aging (Albany NY), 2020 Apr 03; 12(7). PMID: 32240105    Free PMC article.
Tumor mutation burden and circulating tumor DNA in combined CTLA-4 and PD-1 antibody therapy in metastatic melanoma - results of a prospective biomarker study.
Andrea Forschner, Florian Battke, +15 authors, Saskia Biskup.
J Immunother Cancer, 2019 Jul 14; 7(1). PMID: 31300034    Free PMC article.
Highly Cited.
Heterogeneous responses in hepatocellular carcinoma: the achilles heel of immune checkpoint inhibitors.
Zuyuan Lin, Di Lu, +2 authors, Xiao Xu.
Am J Cancer Res, 2020 May 06; 10(4). PMID: 32368387    Free PMC article.
Review.
The role of the immune system in brain metastasis.
Adam T Leibold, Gina N Monaco, Mahua Dey.
Curr Neurobiol, 2019 May 18; 10(2). PMID: 31097897    Free PMC article.
The new identified biomarkers determine sensitivity to immune check-point blockade therapies in melanoma.
Hao Chen, Meng Yang, +3 authors, Kexin Chen.
Oncoimmunology, 2019 Aug 16; 8(8). PMID: 31413919    Free PMC article.
Characterization of the prognostic values and response to immunotherapy/chemotherapy of Krüppel-like factors in prostate cancer.
Jialin Meng, Xiaofan Lu, +5 authors, Chaozhao Liang.
J Cell Mol Med, 2020 Apr 14; 24(10). PMID: 32281273    Free PMC article.
The Tumor Microenvironment in the Response to Immune Checkpoint Blockade Therapies.
Florent Petitprez, Maxime Meylan, +2 authors, Wolf H Fridman.
Front Immunol, 2020 May 28; 11. PMID: 32457745    Free PMC article.
Review.
Biological Factors behind Melanoma Response to Immune Checkpoint Inhibitors.
Magdalena Olbryt, Marcin Rajczykowski, Wiesława Widłak.
Int J Mol Sci, 2020 Jun 11; 21(11). PMID: 32517213    Free PMC article.
Review.
Sequential ctDNA whole-exome sequencing in advanced lung adenocarcinoma with initial durable tumor response on immune checkpoint inhibitor and late progression.
Etienne Giroux Leprieur, Zofia Hélias-Rodzewicz, +10 authors, Jean-François Emile.
J Immunother Cancer, 2020 Jun 26; 8(1). PMID: 32581058    Free PMC article.
Chromosome Abnormalities: New Insights into Their Clinical Significance in Cancer.
Fan Kou, Lei Wu, Xiubao Ren, Lili Yang.
Mol Ther Oncolytics, 2020 Jul 09; 17. PMID: 32637574    Free PMC article.
Review.
Comprehensive investigation of T and B cell receptor repertoires in an MC38 tumor model following murine anti‑PD‑1 administration.
Lu Zhang, I-Ming Wang, +3 authors, Brian Long.
Mol Med Rep, 2020 May 30; 22(2). PMID: 32468004    Free PMC article.
Resistance to immune checkpoint inhibitors in non-small cell lung cancer: biomarkers and therapeutic strategies.
Robert J Walsh, Ross A Soo.
Ther Adv Med Oncol, 2020 Jul 17; 12. PMID: 32670423    Free PMC article.
Review.
Toward Systems Biomarkers of Response to Immune Checkpoint Blockers.
Óscar Lapuente-Santana, Federica Eduati.
Front Oncol, 2020 Jul 17; 10. PMID: 32670886    Free PMC article.
Review.
DNA Repair Gene Mutations as Predictors of Immune Checkpoint Inhibitor Response beyond Tumor Mutation Burden.
David Hsiehchen, Antony Hsieh, +6 authors, Hao Zhu.
Cell Rep Med, 2020 Jul 18; 1(3). PMID: 32676589    Free PMC article.
Computational Identification of Tumor Suppressor Genes Based on Gene Expression Profiles in Normal and Cancerous Gastrointestinal Tissues.
Qingrong Sun, Md Nazim Uddin, +2 authors, Maode Lai.
J Oncol, 2020 Aug 11; 2020. PMID: 32774369    Free PMC article.
Escape from nonsense-mediated decay associates with anti-tumor immunogenicity.
Kevin Litchfield, James L Reading, +17 authors, Charles Swanton.
Nat Commun, 2020 Aug 01; 11(1). PMID: 32733040    Free PMC article.
Tumor copy-number alterations predict response to immune-checkpoint-blockade in gastrointestinal cancer.
Zhihao Lu, Huan Chen, +14 authors, Lin Shen.
J Immunother Cancer, 2020 Aug 15; 8(2). PMID: 32792358    Free PMC article.
Mechanisms of Cancer Resistance to Immunotherapy.
Rilan Bai, Naifei Chen, +5 authors, Jiuwei Cui.
Front Oncol, 2020 Aug 28; 10. PMID: 32850400    Free PMC article.
Review.
PTEN Function at the Interface between Cancer and Tumor Microenvironment: Implications for Response to Immunotherapy.
Fabiana Conciatori, Chiara Bazzichetto, +6 authors, Michele Milella.
Int J Mol Sci, 2020 Jul 31; 21(15). PMID: 32727102    Free PMC article.
Review.
Predictive biomarkers for cancer immunotherapy with immune checkpoint inhibitors.
Rilan Bai, Zheng Lv, Dongsheng Xu, Jiuwei Cui.
Biomark Res, 2020 Aug 31; 8. PMID: 32864131    Free PMC article.
Review.
Association of MUC16 Mutation With Response to Immune Checkpoint Inhibitors in Solid Tumors.
Lei Zhang, Xiaohong Han, Yuankai Shi.
JAMA Netw Open, 2020 Aug 28; 3(8). PMID: 32845327    Free PMC article.
Clinical and molecular correlates of PD-L1 expression in patients with lung adenocarcinomas.
A J Schoenfeld, H Rizvi, +15 authors, M D Hellmann.
Ann Oncol, 2020 Mar 18; 31(5). PMID: 32178965    Free PMC article.
Biomarkers of the Response to Immune Checkpoint Inhibitors in Metastatic Urothelial Carcinoma.
Siteng Chen, Ning Zhang, +3 authors, Junhua Zheng.
Front Immunol, 2020 Sep 29; 11. PMID: 32983112    Free PMC article.
Multimodal genomic features predict outcome of immune checkpoint blockade in non-small-cell lung cancer.
Valsamo Anagnostou, Noushin Niknafs, +32 authors, Victor E Velculescu.
Nat Cancer, 2020 Sep 29; 1(1). PMID: 32984843    Free PMC article.
Identification of potential biomarkers and their clinical significance in gastric cancer using bioinformatics analysis methods.
Jie Liu, Miao Zhou, +3 authors, Hongyun Li.
PeerJ, 2020 Oct 17; 8. PMID: 33062405    Free PMC article.
T-cell receptor repertoire analysis for the diagnosis and treatment of solid tumor: A methodology and clinical applications.
Na Li, Jiani Yuan, +2 authors, Yongyu Liu.
Cancer Commun (Lond), 2020 Jul 18; 40(10). PMID: 32677768    Free PMC article.
Review.
Pharmacogenomics for immunotherapy and immune-related cardiotoxicity.
Jessica A Castrillon, Charis Eng, Feixiong Cheng.
Hum Mol Genet, 2020 Jul 06; 29(R2). PMID: 32620943    Free PMC article.
Review.
Genomics-based immuno-oncology: bridging the gap between immunology and tumor biology.
Renzo G DiNatale, A Ari Hakimi, Timothy A Chan.
Hum Mol Genet, 2020 Oct 09; 29(R2). PMID: 33029628    Free PMC article.
Review.
Identification of Four Immune Subtypes in Bladder Cancer Based on Immune Gene Sets.
Chaozhi Tang, Jiakang Ma, Xiuli Liu, Zhengchun Liu.
Front Oncol, 2020 Oct 30; 10. PMID: 33117683    Free PMC article.
Development and validation of a novel stem cell subtype for bladder cancer based on stem genomic profiling.
Chaozhi Tang, Jiakang Ma, Xiuli Liu, Zhengchun Liu.
Stem Cell Res Ther, 2020 Oct 30; 11(1). PMID: 33115513    Free PMC article.
Melanoma Evolves Complete Immunotherapy Resistance through the Acquisition of a Hypermetabolic Phenotype.
Ashvin R Jaiswal, Arthur J Liu, +17 authors, Michael A Curran.
Cancer Immunol Res, 2020 Sep 13; 8(11). PMID: 32917656    Free PMC article.
Multiomics profiling of primary lung cancers and distant metastases reveals immunosuppression as a common characteristic of tumor cells with metastatic plasticity.
Won-Chul Lee, Alexandre Reuben, +43 authors, Jianjun Zhang.
Genome Biol, 2020 Nov 06; 21(1). PMID: 33148332    Free PMC article.
Characteristics of TCR Repertoire Associated With Successful Immune Checkpoint Therapy Responses.
Joel Kidman, Nicola Principe, +6 authors, Jonathan Chee.
Front Immunol, 2020 Nov 10; 11. PMID: 33163002    Free PMC article.
Review.
Study and analysis of antitumor resistance mechanism of PD1/PD-L1 immune checkpoint blocker.
Zhengyi Wang, Xiaoying Wu.
Cancer Med, 2020 Sep 03; 9(21). PMID: 32875727    Free PMC article.
Review.
Focus on Biochemical and Clinical Predictors of Response to Immune Checkpoint Inhibitors in Metastatic Urothelial Carcinoma: Where Do We Stand?
Giandomenico Roviello, Martina Catalano, +3 authors, Gabriella Nesi.
Int J Mol Sci, 2020 Oct 30; 21(21). PMID: 33114616    Free PMC article.
Review.
Immune-related miRNA signature identifies prognosis and immune landscape in head and neck squamous cell carcinomas.
Bo Ma, Hui Li, +2 authors, Riyue Yu.
Biosci Rep, 2020 Oct 29; 40(11). PMID: 33111959    Free PMC article.
Plasma-derived extracellular vesicle analysis and deconvolution enable prediction and tracking of melanoma checkpoint blockade outcome.
Alvin Shi, Gyulnara G Kasumova, +13 authors, Genevieve M Boland.
Sci Adv, 2020 Nov 15; 6(46). PMID: 33188016    Free PMC article.
Multimodal Treatment of Advanced Mucosal Melanoma in the Era of Modern Immunotherapy.
Pawel Teterycz, Anna M Czarnecka, +11 authors, Piotr Rutkowski.
Cancers (Basel), 2020 Oct 30; 12(11). PMID: 33114734    Free PMC article.
The Underlying Tumor Genomics of Predominant Histologic Subtypes in Lung Adenocarcinoma.
Raul Caso, Francisco Sanchez-Vega, +16 authors, David R Jones.
J Thorac Oncol, 2020 Aug 14; 15(12). PMID: 32791233    Free PMC article.
Immune tumor board: integral part in the multidisciplinary management of cancer patients treated with cancer immunotherapy.
Heinz Läubli, Stefan Dirnhofer, Alfred Zippelius.
Virchows Arch, 2018 Aug 26; 474(4). PMID: 30143868
Mechanisms of Resistance to Immune Checkpoint Blockade.
David Liu, Russell W Jenkins, Ryan J Sullivan.
Am J Clin Dermatol, 2018 Sep 28; 20(1). PMID: 30259383    Free PMC article.
Review.
Pan-tumor genomic biomarkers for PD-1 checkpoint blockade-based immunotherapy.
Razvan Cristescu, Robin Mogg, +21 authors, David Kaufman.
Science, 2018 Oct 13; 362(6411). PMID: 30309915    Free PMC article.
Highly Cited.
Immunosuppressive circuits in tumor microenvironment and their influence on cancer treatment efficacy.
Alessandra Tuccitto, Eriomina Shahaj, +6 authors, Viviana Vallacchi.
Virchows Arch, 2018 Oct 31; 474(4). PMID: 30374798
Review.
The evolving landscape of biomarkers for checkpoint inhibitor immunotherapy.
Jonathan J Havel, Diego Chowell, Timothy A Chan.
Nat Rev Cancer, 2019 Feb 14; 19(3). PMID: 30755690    Free PMC article.
Highly Cited. Review.
Implementing TMB measurement in clinical practice: considerations on assay requirements.
Reinhard Büttner, John W Longshore, +4 authors, Frédérique Penault-Llorca.
ESMO Open, 2019 Feb 23; 4(1). PMID: 30792906    Free PMC article.
Highly Cited.
PD-1/PD-L1 blockade in cervical cancer: current studies and perspectives.
Yumeng Wang, Guiling Li.
Front Med, 2019 Mar 04; 13(4). PMID: 30826965
Review.
Immune Signature-Based Subtypes of Cervical Squamous Cell Carcinoma Tightly Associated with Human Papillomavirus Type 16 Expression, Molecular Features, and Clinical Outcome.
Xiaofan Lu, Liyun Jiang, +9 authors, Fangrong Yan.
Neoplasia, 2019 May 06; 21(6). PMID: 31055200    Free PMC article.
Copy-Number Alteration Burden Differentially Impacts Immune Profiles and Molecular Features of Hepatocellular Carcinoma.
Laia Bassaganyas, Roser Pinyol, +11 authors, Josep M Llovet.
Clin Cancer Res, 2020 Sep 03; 26(23). PMID: 32873569    Free PMC article.
Integrated molecular drivers coordinate biological and clinical states in melanoma.
Jake R Conway, Felix Dietlein, +13 authors, Eliezer M Van Allen.
Nat Genet, 2020 Nov 25; 52(12). PMID: 33230298    Free PMC article.
Tumor Infiltrating Effector Memory Antigen-Specific CD8+ T Cells Predict Response to Immune Checkpoint Therapy.
Nicola Principe, Joel Kidman, +15 authors, Jonathan Chee.
Front Immunol, 2020 Dec 03; 11. PMID: 33262762    Free PMC article.
SITC cancer immunotherapy resource document: a compass in the land of biomarker discovery.
Siwen Hu-Lieskovan, Srabani Bhaumik, +14 authors, Holden T Maecker.
J Immunother Cancer, 2020 Dec 04; 8(2). PMID: 33268350    Free PMC article.
Molecular analysis of primary melanoma T cells identifies patients at risk for metastatic recurrence.
Wiebke Pruessmann, Julie Rytlewski, +14 authors, Thomas S Kupper.
Nat Cancer, 2020 Dec 12; 1(2). PMID: 33305293    Free PMC article.
Metabolism-Associated Molecular Classification of Colorectal Cancer.
Meng Zhang, Hai-Zhou Wang, +3 authors, Qiu Zhao.
Front Oncol, 2020 Dec 22; 10. PMID: 33344254    Free PMC article.
Molecular Biomarkers of Response to PD-1/ PD-L1 Immune Checkpoint Blockade in Advanced Bladder Cancer.
Megan M Tu, Terry L Ng, +3 authors, Dan Theodorescu.
Bladder Cancer, 2019 Aug 16; 5(2). PMID: 33365377    Free PMC article.
Systematic Review.
Antagonistic Inflammatory Phenotypes Dictate Tumor Fate and Response to Immune Checkpoint Blockade.
Eduardo Bonavita, Christian P Bromley, +17 authors, Santiago Zelenay.
Immunity, 2020 Nov 22; 53(6). PMID: 33220234    Free PMC article.
Construction of immune-related gene pairs signature to predict the overall survival of osteosarcoma patients.
Long-Qing Li, Liang-Hao Zhang, +7 authors, Jia-Zhen Li.
Aging (Albany NY), 2020 Nov 19; 12(22). PMID: 33203792    Free PMC article.
Comprehensive characterization of the tumor microenvironment for assessing immunotherapy outcome in patients with head and neck squamous cell carcinoma.
Jian Zhang, Xi Zhong, +7 authors, Yawei Yuan.
Aging (Albany NY), 2020 Nov 21; 12(22). PMID: 33216727    Free PMC article.
A TP53-Associated Immune Prognostic Signature for the Prediction of Overall Survival and Therapeutic Responses in Muscle-Invasive Bladder Cancer.
Xiangkun Wu, Daojun Lv, +4 authors, Yongda Liu.
Front Immunol, 2021 Jan 05; 11. PMID: 33391264    Free PMC article.
LNK suppresses interferon signaling in melanoma.
Ling-Wen Ding, Qiao-Yang Sun, +17 authors, H Phillip Koeffler.
Nat Commun, 2019 May 22; 10(1). PMID: 31110180    Free PMC article.
PPP2R2B downregulation is associated with immune evasion and predicts poor clinical outcomes in triple-negative breast cancer.
Zheng Li, Yaming Li, Xiaolong Wang, Qifeng Yang.
Cancer Cell Int, 2021 Jan 08; 21(1). PMID: 33407498    Free PMC article.
A novel immune classification reveals distinct immune escape mechanism and genomic alterations: implications for immunotherapy in hepatocellular carcinoma.
Zaoqu Liu, Yuyuan Zhang, +5 authors, Xinwei Han.
J Transl Med, 2021 Jan 08; 19(1). PMID: 33407585    Free PMC article.
Genomic profiles and tumor immune microenvironment of primary lung carcinoma and brain oligo-metastasis.
Zhengbo Song, Ling Yang, +11 authors, Ming Chen.
Cell Death Dis, 2021 Jan 23; 12(1). PMID: 33479213    Free PMC article.
Hypoxia Molecular Characterization in Hepatocellular Carcinoma Identifies One Risk Signature and Two Nomograms for Clinical Management.
Zaoqu Liu, Long Liu, +4 authors, Xinwei Han.
J Oncol, 2021 Feb 09; 2021. PMID: 33552157    Free PMC article.
Conserved Interferon-γ Signaling Drives Clinical Response to Immune Checkpoint Blockade Therapy in Melanoma.
Catherine S Grasso, Jennifer Tsoi, +33 authors, Antoni Ribas.
Cancer Cell, 2020 Sep 12; 38(4). PMID: 32916126    Free PMC article.
Comprehensive Characterization of Alternative mRNA Splicing Events in Glioblastoma: Implications for Prognosis, Molecular Subtypes, and Immune Microenvironment Remodeling.
Liang Zhao, Jiayue Zhang, +3 authors, Peng Zhao.
Front Oncol, 2021 Feb 13; 10. PMID: 33575206    Free PMC article.
Development of a Metastasis-Related Immune Prognostic Model of Metastatic Colorectal Cancer and Its Usefulness to Immunotherapy.
Zhiwen Luo, Xiao Chen, +8 authors, Xinyu Bi.
Front Cell Dev Biol, 2021 Feb 16; 8. PMID: 33585439    Free PMC article.
Ratio of the interferon-γ signature to the immunosuppression signature predicts anti-PD-1 therapy response in melanoma.
Chuanliang Cui, Canqiang Xu, +9 authors, Yan Kong.
NPJ Genom Med, 2021 Feb 06; 6(1). PMID: 33542239    Free PMC article.
Molecular and Clinicopathological Characterization of a Prognostic Immune Gene Signature Associated With MGMT Methylation in Glioblastoma.
Liang Zhao, Jiayue Zhang, +3 authors, Peng Zhao.
Front Cell Dev Biol, 2021 Feb 23; 9. PMID: 33614641    Free PMC article.
NF-κB in Cancer Immunity: Friend or Foe?
Guilhem Lalle, Julie Twardowski, Yenkel Grinberg-Bleyer.
Cells, 2021 Feb 13; 10(2). PMID: 33572260    Free PMC article.
Review.
Tumor immune microenvironment-based classifications of bladder cancer for enhancing the response rate of immunotherapy.
Jialin Meng, Xiaofan Lu, +7 authors, Chaozhao Liang.
Mol Ther Oncolytics, 2021 Mar 06; 20. PMID: 33665361    Free PMC article.
DNA Damage Repair Gene Mutations Are Indicative of a Favorable Prognosis in Colorectal Cancer Treated With Immune Checkpoint Inhibitors.
Yipeng Song, Jian Huang, +10 authors, Shukun Zhang.
Front Oncol, 2021 Mar 09; 10. PMID: 33680909    Free PMC article.
The Identification and Validation of a Robust Immune-Associated Gene Signature in Cutaneous Melanoma.
Le-Bin Song, Jiao-Chen Luan, +5 authors, Yan Lu.
J Immunol Res, 2021 Mar 11; 2021. PMID: 33688507    Free PMC article.
Meta-analysis of tumor- and T cell-intrinsic mechanisms of sensitization to checkpoint inhibition.
Kevin Litchfield, James L Reading, +25 authors, Charles Swanton.
Cell, 2021 Jan 29; 184(3). PMID: 33508232    Free PMC article.
Tumour microenvironment-based molecular profiling reveals ideal candidates for high-grade serous ovarian cancer immunotherapy.
Xiaofan Lu, Caoyu Ji, +7 authors, Fangrong Yan.
Cell Prolif, 2021 Feb 02; 54(3). PMID: 33522069    Free PMC article.
Genetic and non-genetic clonal diversity in cancer evolution.
James R M Black, Nicholas McGranahan.
Nat Rev Cancer, 2021 Mar 18; 21(6). PMID: 33727690
Review.
Overcoming Resistance to Immune Checkpoint Inhibitors in Head and Neck Squamous Cell Carcinomas.
Lucas V Dos Santos, Carina M Abrahão, William N William.
Front Oncol, 2021 Mar 23; 11. PMID: 33747915    Free PMC article.
Review.
Development of a novel transcription factors-related prognostic signature for serous ovarian cancer.
He Li, Nayiyuan Wu, +3 authors, Jing Wang.
Sci Rep, 2021 Apr 01; 11(1). PMID: 33785763    Free PMC article.
Defining Immunogenic and Radioimmunogenic Tumors.
Terry R Medler, Tiffany C Blair, Marka R Crittenden, Michael J Gough.
Front Oncol, 2021 Apr 06; 11. PMID: 33816320    Free PMC article.
Review.
Shared Immunogenic Poly-Epitope Frameshift Mutations in Microsatellite Unstable Tumors.
Vladimir Roudko, Cansu Cimen Bozkus, +9 authors, Nina Bhardwaj.
Cell, 2020 Dec 02; 183(6). PMID: 33259803    Free PMC article.
Immune-Related Mutational Landscape and Gene Signatures: Prognostic Value and Therapeutic Impact for Head and Neck Cancer.
Bohai Feng, Jochen Hess.
Cancers (Basel), 2021 Apr 04; 13(5). PMID: 33800421    Free PMC article.
Review.
Molecular profiling of long-term responders to immune checkpoint inhibitors in advanced non-small cell lung cancer.
Joan Frigola, Alejandro Navarro, +17 authors, Ramon Amat.
Mol Oncol, 2020 Dec 21; 15(4). PMID: 33342055    Free PMC article.
Genome-Wide Analyses of Prognostic and Therapeutic Alternative Splicing Signatures in Bladder Urothelial Carcinoma.
Zhongru Fan, Zhe Zhang, +3 authors, Chuize Kong.
Front Oncol, 2021 Apr 13; 11. PMID: 33842332    Free PMC article.
Identification of a Novel Protein-Based Signature to Improve Prognosis Prediction in Renal Clear Cell Carcinoma.
Guangdi Chu, Ting Xu, +3 authors, Mingxin Zhang.
Front Mol Biosci, 2021 Apr 13; 8. PMID: 33842538    Free PMC article.
Common germline variants of the human APOE gene modulate melanoma progression and survival.
Benjamin N Ostendorf, Jana Bilanovic, +4 authors, Sohail F Tavazoie.
Nat Med, 2020 May 27; 26(7). PMID: 32451497    Free PMC article.
Identification and Validation of an Immune-Associated RNA-Binding Proteins Signature to Predict Clinical Outcomes and Therapeutic Responses in Glioma Patients.
Ruotong Tian, Yimin Li, Qian Liu, Minfeng Shu.
Cancers (Basel), 2021 May 01; 13(7). PMID: 33917399    Free PMC article.
Find the Flame: Predictive Biomarkers for Immunotherapy in Melanoma.
Mattia Garutti, Serena Bonin, +4 authors, Fabio Puglisi.
Cancers (Basel), 2021 May 01; 13(8). PMID: 33920288    Free PMC article.
Review.
Analysis of Tumor Microenvironment Characteristics in Bladder Cancer: Implications for Immune Checkpoint Inhibitor Therapy.
Xingyu Chen, Haotian Chen, +6 authors, Ke Cao.
Front Immunol, 2021 May 04; 12. PMID: 33936117    Free PMC article.
Immune response drives outcomes in prostate cancer: implications for immunotherapy.
Jialin Meng, Yujie Zhou, +7 authors, Chaozhao Liang.
Mol Oncol, 2020 Dec 19; 15(5). PMID: 33338321    Free PMC article.
Comprehensive analysis of genomic and immunological profiles in Chinese and Western hepatocellular carcinoma populations.
Wei Li, Hong Wu, Xuewen Xu, Yange Zhang.
Aging (Albany NY), 2021 Apr 20; 13(8). PMID: 33867349    Free PMC article.
The Dynamic Entropy of Tumor Immune Infiltrates: The Impact of Recirculation, Antigen-Specific Interactions, and Retention on T Cells in Tumors.
Tiffany C Blair, Alejandro F Alice, +2 authors, Michael J Gough.
Front Oncol, 2021 May 11; 11. PMID: 33968757    Free PMC article.
Review.
Immune evasion in HPV- head and neck precancer-cancer transition is driven by an aneuploid switch involving chromosome 9p loss.
William N William, Xin Zhao, +12 authors, Scott M Lippman.
Proc Natl Acad Sci U S A, 2021 May 07; 118(19). PMID: 33952700    Free PMC article.
Cell-free DNA copy number variations predict efficacy of immune checkpoint inhibitor-based therapy in hepatobiliary cancers.
Xu Yang, Ying Hu, +17 authors, Haitao Zhao.
J Immunother Cancer, 2021 May 12; 9(5). PMID: 33972389    Free PMC article.
Targeting DNA Damage Repair for Immune Checkpoint Inhibition: Mechanisms and Potential Clinical Applications.
Wei Sun, Qing Zhang, +3 authors, Lin Yang.
Front Oncol, 2021 May 25; 11. PMID: 34026622    Free PMC article.
Review.
Identification of immune subtypes of cervical squamous cell carcinoma predicting prognosis and immunotherapy responses.
Yimin Li, Shun Lu, +2 authors, Jinyi Lang.
J Transl Med, 2021 May 26; 19(1). PMID: 34030694    Free PMC article.
Ubiquitin Modification Patterns of Clear Cell Renal Cell Carcinoma and the Ubiquitin Score to Aid Immunotherapy and Targeted Therapy.
Peng Zhou, Yuchao Lu, +6 authors, Jia Hu.
Front Cell Dev Biol, 2021 Jun 01; 9. PMID: 34055790    Free PMC article.
Identification of a tumor microenvironment-associated prognostic gene signature in bladder cancer by integrated bioinformatic analysis.
Zhengchun Liu, Xiuli Liu, +2 authors, Rensheng Wang.
Int J Clin Exp Pathol, 2021 Jun 08; 14(5). PMID: 34093942    Free PMC article.
Construction of a Promising Tumor-Infiltrating CD8+ T Cells Gene Signature to Improve Prediction of the Prognosis and Immune Response of Uveal Melanoma.
Yifang Sun, Jian Wu, +4 authors, Shengsheng Ma.
Front Cell Dev Biol, 2021 Jun 15; 9. PMID: 34124058    Free PMC article.
Peripheral CD8+ T cell characteristics associated with durable responses to immune checkpoint blockade in patients with metastatic melanoma.
Benjamin P Fairfax, Chelsea A Taylor, +12 authors, Mark R Middleton.
Nat Med, 2020 Feb 12; 26(2). PMID: 32042196    Free PMC article.
Diversity of Dominant Peripheral T Cell Receptor Clone and Soluble Immune Checkpoint Proteins Associated With Clinical Outcomes Following Immune Checkpoint Inhibitor Treatment in Advanced Cancers.
Ye Li, Jiaqian Wang, +6 authors, Shunchang Jiao.
Front Immunol, 2021 Jun 25; 12. PMID: 34163469    Free PMC article.
CD8+ T cell immunity blocks the metastasis of carcinogen-exposed breast cancer.
Kaiwen Li, Tiancheng Li, +9 authors, Shadmehr Demehri.
Sci Adv, 2021 Jun 20; 7(25). PMID: 34144976    Free PMC article.
RNA N 6-Methyladenosine in Cancer Metastasis: Roles, Mechanisms, and Applications.
Qin Dang, Bo Shao, +7 authors, Zhenqiang Sun.
Front Oncol, 2021 Jul 03; 11. PMID: 34211849    Free PMC article.
Review.
Gut microbiota signatures are associated with toxicity to combined CTLA-4 and PD-1 blockade.
Miles C Andrews, Connie P M Duong, +68 authors, Jennifer A Wargo.
Nat Med, 2021 Jul 10; 27(8). PMID: 34239137
Early B-cell factors involve in the tumorigenesis and predict the overall survival of gastric cancer.
Qing Wang, Jiahong Liang, +3 authors, Jiang Yan.
Biosci Rep, 2021 Jun 09; 41(7). PMID: 34100918    Free PMC article.
MHC Class I Deficiency in Solid Tumors and Therapeutic Strategies to Overcome It.
Elena Shklovskaya, Helen Rizos.
Int J Mol Sci, 2021 Jul 03; 22(13). PMID: 34201655    Free PMC article.
Review.
Signature based on metabolic-related gene pairs can predict overall survival of osteosarcoma patients.
Long-Qing Li, Liang-Hao Zhang, +8 authors, Yan Zhang.
Cancer Med, 2021 May 29; 10(13). PMID: 34047495    Free PMC article.
Phase II Clinical Trial of Everolimus in a Pan-Cancer Cohort of Patients with mTOR Pathway Alterations.
Elio Adib, Katarzyna Klonowska, +16 authors, David J Kwiatkowski.
Clin Cancer Res, 2021 Mar 18; 27(14). PMID: 33727259    Free PMC article.
Reactivation of the tumor suppressor PTEN by mRNA nanoparticles enhances antitumor immunity in preclinical models.
Yao-Xin Lin, Yi Wang, +10 authors, Jinjun Shi.
Sci Transl Med, 2021 Jun 25; 13(599). PMID: 34162754    Free PMC article.
Metabolism-Relevant Molecular Classification Identifies Tumor Immune Microenvironment Characterization and Immunotherapeutic Effect in Cervical Cancer.
Luyi Li, Hui Gao, +5 authors, Changjiang Huang.
Front Mol Biosci, 2021 Jul 20; 8. PMID: 34277697    Free PMC article.
The T cell receptor repertoire of tumor infiltrating T cells is predictive and prognostic for cancer survival.
Sara Valpione, Piyushkumar A Mundra, +8 authors, Richard Marais.
Nat Commun, 2021 Jul 04; 12(1). PMID: 34215730    Free PMC article.
An Immune-Gene-Based Classifier Predicts Prognosis in Patients With Cervical Squamous Cell Carcinoma.
Huixia Yang, Xiaoyan Han, Zengping Hao.
Front Mol Biosci, 2021 Jul 23; 8. PMID: 34291084    Free PMC article.
Comprehensive Molecular Analyses of a Novel Mutational Signature Classification System with Regard to Prognosis, Genomic Alterations, and Immune Landscape in Glioma.
Zaoqu Liu, Taoyuan Lu, +3 authors, Xinwei Han.
Front Mol Biosci, 2021 Jul 27; 8. PMID: 34307451    Free PMC article.
Identification and Validation of Immune Molecular Subtypes in Pancreatic Ductal Adenocarcinoma: Implications for Prognosis and Immunotherapy.
Ruiyu Li, Yangzhige He, +5 authors, Zhiyong Liang.
Front Immunol, 2021 Aug 03; 12. PMID: 34335594    Free PMC article.
Multi-Omics Profiling Identifies Risk Hypoxia-Related Signatures for Ovarian Cancer Prognosis.
Xingyu Chen, Hua Lan, +6 authors, Ke Cao.
Front Immunol, 2021 Aug 06; 12. PMID: 34349753    Free PMC article.
A novel signature constructed by ferroptosis-associated genes (FAGs) for the prediction of prognosis in bladder urothelial carcinoma (BLCA) and associated with immune infiltration.
Jiao-Chen Luan, Teng-Yue Zeng, +9 authors, Ning-Hong Song.
Cancer Cell Int, 2021 Aug 08; 21(1). PMID: 34362387    Free PMC article.
Cellular based immunotherapy for primary liver cancer.
Yuanyuan Zheng, Yan Li, +8 authors, Chuanyong Guo.
J Exp Clin Cancer Res, 2021 Aug 11; 40(1). PMID: 34372912    Free PMC article.
Review.
Greater extent of blood-tumor TCR repertoire overlap is associated with favorable clinical responses to PD-1 blockade.
Hiroyasu Aoki, Satoshi Ueha, +7 authors, Kouji Matsushima.
Cancer Sci, 2021 May 21; 112(8). PMID: 34014607    Free PMC article.
Downregulated ARID1A by miR-185 Is Associated With Poor Prognosis and Adverse Outcomes in Colon Adenocarcinoma.
Salem Baldi, Hassan Khamgan, +7 authors, Yun-Fei Zuo.
Front Oncol, 2021 Aug 21; 11. PMID: 34414106    Free PMC article.
Identification of Nephrogenic Therapeutic Biomarkers of Wilms Tumor Using Machine Learning.
Hanxiang Liu, Chaozhi Tang, Yi Yang.
J Oncol, 2021 Aug 24; 2021. PMID: 34422051    Free PMC article.
Interpretable systems biomarkers predict response to immune-checkpoint inhibitors.
Óscar Lapuente-Santana, Maisa van Genderen, +2 authors, Federica Eduati.
Patterns (N Y), 2021 Aug 26; 2(8). PMID: 34430923    Free PMC article.
The Identification of the Metabolism Subtypes of Skin Cutaneous Melanoma Associated With the Tumor Microenvironment and the Immunotherapy.
Ronghua Yang, Zhengguang Wang, +5 authors, Sitong Zhou.
Front Cell Dev Biol, 2021 Aug 31; 9. PMID: 34458265    Free PMC article.
Upregulation of HOXC9 generates interferon-gamma resistance in gastric cancer by inhibiting the DAPK1/RIG1/STAT1 axis.
Yuanxin Tang, Taifang Wang, +2 authors, Chunli Wu.
Cancer Sci, 2021 Jun 24; 112(9). PMID: 34159686    Free PMC article.
High Response Rate and Durability Driven by HLA Genetic Diversity in Patients with Kidney Cancer Treated with Lenvatinib and Pembrolizumab.
Chung-Han Lee, Renzo G DiNatale, +23 authors, Timothy A Chan.
Mol Cancer Res, 2021 May 28; 19(9). PMID: 34039647    Free PMC article.
Immune Infiltrating Cells-Derived Risk Signature Based on Large-scale Analysis Defines Immune Landscape and Predicts Immunotherapy Responses in Glioma Tumor Microenvironment.
Nan Zhang, Hao Zhang, +4 authors, Zhixiong Liu.
Front Immunol, 2021 Sep 08; 12. PMID: 34489938    Free PMC article.
Immune Checkpoint Inhibitors in Urothelial Bladder Cancer: State of the Art and Future Perspectives.
Giandomenico Roviello, Martina Catalano, +7 authors, Gabriella Nesi.
Cancers (Basel), 2021 Sep 11; 13(17). PMID: 34503220    Free PMC article.
Review.
Multi-omics Analysis of Ferroptosis Regulation Patterns and Characterization of Tumor Microenvironment in Patients with Oral Squamous Cell Carcinoma.
Wenchao Gu, Mai Kim, +3 authors, Yoshito Tsushima.
Int J Biol Sci, 2021 Sep 14; 17(13). PMID: 34512160    Free PMC article.
CD8+ T effector and immune checkpoint signatures predict prognosis and responsiveness to immunotherapy in bladder cancer.
Xingyu Chen, Runshi Xu, +11 authors, Ke Cao.
Oncogene, 2021 Sep 24; 40(43). PMID: 34552192
Evolution of delayed resistance to immunotherapy in a melanoma responder.
David Liu, Jia-Ren Lin, +37 authors, Genevieve M Boland.
Nat Med, 2021 May 05; 27(6). PMID: 33941922    Free PMC article.
NSCLC Biomarkers to Predict Response to Immunotherapy with Checkpoint Inhibitors (ICI): From the Cells to In Vivo Images.
Virginia Liberini, Annapaola Mariniello, +7 authors, Désirée Deandreis.
Cancers (Basel), 2021 Sep 29; 13(18). PMID: 34572771    Free PMC article.
Review.
Identification of Immune Function-Related Subtypes in Cutaneous Melanoma.
Lin Liu, Junkai Zhu, +6 authors, Fangrong Yan.
Life (Basel), 2021 Sep 29; 11(9). PMID: 34575074    Free PMC article.
Novel Immune Infiltrating Cell Signature Based on Cell Pair Algorithm Is a Prognostic Marker in Cancer.
Hao Zhang, Zeyu Wang, +5 authors, Quan Cheng.
Front Immunol, 2021 Oct 02; 12. PMID: 34594324    Free PMC article.
Characterization of Molecular Subtypes in Head and Neck Squamous Cell Carcinoma With Distinct Prognosis and Treatment Responsiveness.
Pei Zhang, Shue Li, +4 authors, Xia Sheng.
Front Cell Dev Biol, 2021 Oct 02; 9. PMID: 34595167    Free PMC article.
Network for Biomarker Immunoprofiling for Cancer Immunotherapy: Cancer Immune Monitoring and Analysis Centers and Cancer Immunologic Data Commons (CIMAC-CIDC).
Helen X Chen, Minkyung Song, +37 authors, Magdalena Thurin.
Clin Cancer Res, 2021 Jan 10; 27(18). PMID: 33419780    Free PMC article.
Classification of Estrogen Receptor-Positive Breast Cancer Based on Immunogenomic Profiling and Validation at Single-Cell Resolution.
Xianxiong Ma, Hengyu Chen, +4 authors, Lei Li.
Front Cell Dev Biol, 2021 Oct 09; 9. PMID: 34621742    Free PMC article.
Characterization of Molecular Heterogeneity Associated With Tumor Microenvironment in Clear Cell Renal Cell Carcinoma to Aid Immunotherapy.
Weimin Zhong, Yinan Li, +5 authors, Jiyi Huang.
Front Cell Dev Biol, 2021 Oct 12; 9. PMID: 34631713    Free PMC article.
Identification of Mast Cell-Based Molecular Subtypes and a Predictive Signature in Clear Cell Renal Cell Carcinoma.
Hanxiang Liu, Yi Yang.
Front Mol Biosci, 2021 Oct 15; 8. PMID: 34646862    Free PMC article.
Single cell T cell landscape and T cell receptor repertoire profiling of AML in context of PD-1 blockade therapy.
Hussein A Abbas, Dapeng Hao, +31 authors, Andrew Futreal.
Nat Commun, 2021 Oct 20; 12(1). PMID: 34663807    Free PMC article.
9p21 loss confers a cold tumor immune microenvironment and primary resistance to immune checkpoint therapy.
Guangchun Han, Guoliang Yang, +29 authors, Linghua Wang.
Nat Commun, 2021 Sep 25; 12(1). PMID: 34556668    Free PMC article.
Extracellular Matrix-Associated Pathways Promote the Progression of Gastric Cancer by Impacting the Dendritic Cell Axis.
Zhenlin Wang, Zunyun Wang, +3 authors, Gang Pang.
Int J Gen Med, 2021 Oct 23; 14. PMID: 34675633    Free PMC article.
Immune cell infiltration signatures identified molecular subtypes and underlying mechanisms in gastric cancer.
Yilin Lin, Xiaoxian Pan, +8 authors, Zhanlong Shen.
NPJ Genom Med, 2021 Oct 13; 6(1). PMID: 34635662    Free PMC article.
Pathway signatures derived from on-treatment tumor specimens predict response to anti-PD1 blockade in metastatic melanoma.
Kuang Du, Shiyou Wei, +12 authors, Gao Zhang.
Nat Commun, 2021 Oct 17; 12(1). PMID: 34654806    Free PMC article.
Immunogenomic Analyses of the Prognostic Predictive Model for Patients With Renal Cancer.
Tao Feng, Jiahui Zhao, +8 authors, Yong Luo.
Front Immunol, 2021 Oct 30; 12. PMID: 34712244    Free PMC article.
Construction and Validation of an Immune-Related Gene Prognostic Index for Esophageal Squamous Cell Carcinoma.
Qinghua Ji, Yingying Cai, +3 authors, Ruihua Shi.
Biomed Res Int, 2021 Nov 02; 2021. PMID: 34722771    Free PMC article.
Identification and characterization of a 25-lncRNA prognostic signature for early recurrence in hepatocellular carcinoma.
Yi Fu, Xindong Wei, +10 authors, Hailong Wu.
BMC Cancer, 2021 Nov 01; 21(1). PMID: 34717566    Free PMC article.
Alterations of DNA damage response pathway: Biomarker and therapeutic strategy for cancer immunotherapy.
Minlin Jiang, Keyi Jia, +7 authors, Caicun Zhou.
Acta Pharm Sin B, 2021 Nov 04; 11(10). PMID: 34729299    Free PMC article.
Review.
IL-7 coupled with IL-12 increases intratumoral T cell clonality, leading to complete regression of non-immunogenic tumors.
Mamoru Tasaki, Midori Yamashita, +2 authors, Shinsuke Nakao.
Cancer Immunol Immunother, 2021 Apr 29; 70(12). PMID: 33909103    Free PMC article.
Cyclophosphamide enhances the antitumor potency of GITR engagement by increasing oligoclonal cytotoxic T cell fitness.
Daniel Hirschhorn, Allison Betof Warner, +11 authors, Jedd D Wolchok.
JCI Insight, 2021 Oct 23; 6(20). PMID: 34676831    Free PMC article.
Development and Validation of an E2F-Related Gene Signature to Predict Prognosis of Patients With Lung Squamous Cell Carcinoma.
Cailian Wang, Xuyu Gu, +2 authors, Yan Chen.
Front Oncol, 2021 Nov 09; 11. PMID: 34745990    Free PMC article.
MXD1 is a Potential Prognostic Biomarker and Correlated With Specific Molecular Change and Tumor Microenvironment Feature in Esophageal Squamous Cell Carcinoma.
Feng Du, Dezuo Dong, Xiaodong Zhang, Jun Jia.
Technol Cancer Res Treat, 2021 Nov 12; 20. PMID: 34761715    Free PMC article.
Prognosis and Immunotherapy Significances of a Cancer-Associated Fibroblasts-Related Gene Signature in Gliomas.
Zhimin Chen, Shenghua Zhuo, +5 authors, Huiming Xu.
Front Cell Dev Biol, 2021 Nov 16; 9. PMID: 34778248    Free PMC article.
Identification of Potential Prognostic and Predictive Biomarkers for Immune-Checkpoint Inhibitor Response in Small Cell Lung Cancer.
Chanchan Gao, Xuyu Gu, +3 authors, Shiya Zheng.
Med Sci Monit, 2021 Nov 02; 27. PMID: 34719665    Free PMC article.
Sex Disparities of Genomic Determinants in Response to Immune Checkpoint Inhibitors in Melanoma.
Fuyan Shi, Wenjing Zhang, +6 authors, Qinghua Wang.
Front Immunol, 2021 Nov 20; 12. PMID: 34795662    Free PMC article.
Exploration of Redox-Related Molecular Patterns and the Redox Score for Prostate Cancer.
Yue Wu, Xi Zhang, +10 authors, Tao Wang.
Oxid Med Cell Longev, 2021 Nov 23; 2021. PMID: 34804366    Free PMC article.
Immunological and clinical immunotherapy implications of NLRP3 mutations in melanoma.
Qinghua Wang, Juncheng Lyu, +6 authors, Suzhen Wang.
Aging (Albany NY), 2021 Nov 09; 13(21). PMID: 34747716    Free PMC article.
[Expert Consensus on Tumor Mutational Burden for Immunotherapy in Lung Cancer].
Chinese Society of Clinical Oncology, Expert Committee on Tumor Vascular-targeted Therapy, Chinese Society of Clinical Oncology, Expert Committee on Non-small Cell Lung Cancer.
Zhongguo Fei Ai Za Zhi, 2021 Nov 22; 24(11). PMID: 34802204    Free PMC article.
Thymic Function and T-Cell Receptor Repertoire Diversity: Implications for Patient Response to Checkpoint Blockade Immunotherapy.
Antonella Cardinale, Carmen Dolores De Luca, Franco Locatelli, Enrico Velardi.
Front Immunol, 2021 Dec 14; 12. PMID: 34899700    Free PMC article.
Review.
Identification of the Immune Cell Infiltration Landscape in Hepatocellular Carcinoma to Predict Prognosis and Guide Immunotherapy.
Shiyan Yang, Yajun Cheng, +3 authors, Shanzhong Tan.
Front Genet, 2021 Dec 14; 12. PMID: 34899862    Free PMC article.
Identification of a Novel Stem Cell Subtype for Clear Cell Renal Cell Carcinoma Based on Stem Cell Gene Profiling.
Hongzhi Wang, Hanjiang Xu, Quan Cheng, Chaozhao Liang.
Front Oncol, 2021 Dec 17; 11. PMID: 34912710    Free PMC article.
Multi-Omics Analysis of Novel Signature for Immunotherapy Response and Tumor Microenvironment Regulation Patterns in Urothelial Cancer.
Guangdi Chu, Wenhong Shan, +2 authors, Haitao Niu.
Front Cell Dev Biol, 2021 Dec 21; 9. PMID: 34926452    Free PMC article.
Predictive Biomarkers for Outcomes of Immune Checkpoint Inhibitors (ICIs) in Melanoma: A Systematic Review.
Joosje C Baltussen, Marij J P Welters, +7 authors, Nienke A de Glas.
Cancers (Basel), 2021 Dec 25; 13(24). PMID: 34944986    Free PMC article.
Review.
Randomized, open-label, phase 2 study of andecaliximab plus nivolumab versus nivolumab alone in advanced gastric cancer identifies biomarkers associated with survival.
Manish A Shah, David Cunningham, +15 authors, Daniel V T Cantenacci.
J Immunother Cancer, 2021 Dec 12; 9(12). PMID: 34893523    Free PMC article.
Identification of a novel immune signature for optimizing prognosis and treatment prediction in colorectal cancer.
Yan Li, Yiyi Li, +6 authors, Jun Chen.
Aging (Albany NY), 2021 Dec 14; 13(23). PMID: 34898475    Free PMC article.
CD8+ T Cell-Based Molecular Classification With Heterogeneous Immunogenomic Landscapes and Clinical Significance of Clear Cell Renal Cell Carcinoma.
Xiangkun Wu, Dongmei Jiang, +3 authors, Li Liang.
Front Immunol, 2022 Jan 01; 12. PMID: 34970257    Free PMC article.
Identification of an at-risk subpopulation with high immune infiltration based on the peroxisome pathway and TIM3 in colorectal cancer.
Jinwen Yin, Hao Wang, +4 authors, Qiu Zhao.
BMC Cancer, 2022 Jan 09; 22(1). PMID: 34996408    Free PMC article.
m6A Modification Patterns With Distinct Immunity, Metabolism, and Stemness Characteristics in Soft Tissue Sarcoma.
Zhen-Dong Huang, Lu-Lu Lin, +3 authors, Ren-Xiong Wei.
Front Immunol, 2022 Jan 11; 12. PMID: 35003079    Free PMC article.
Molecular Subtypes Based on Cell Differentiation Trajectories in Head and Neck Squamous Cell Carcinoma: Differential Prognosis and Immunotherapeutic Responses.
Zhen-Dong Huang, Zi-Zhen Liu, +5 authors, Ren-Xiong Wei.
Front Immunol, 2022 Jan 11; 12. PMID: 35003112    Free PMC article.
Prediction of biomarkers and therapeutic combinations for anti-PD-1 immunotherapy using the global gene network association.
Chia-Chin Wu, Y Alan Wang, +2 authors, P Andrew Futreal.
Nat Commun, 2022 Jan 12; 13(1). PMID: 35013211    Free PMC article.
Immune-related lncRNA classification of head and neck squamous cell carcinoma.
Ruoyan Cao, Lin Cui, +3 authors, Juan Xia.
Cancer Cell Int, 2022 Jan 17; 22(1). PMID: 35033066    Free PMC article.
Genomic features and tumor immune microenvironment alteration in NSCLC treated with neoadjuvant PD-1 blockade.
Shuhang Wang, Pei Yuan, +12 authors, Jie He.
NPJ Precis Oncol, 2022 Jan 15; 6(1). PMID: 35027673    Free PMC article.
Predictive value of TCR Vβ-Jβ profile for adjuvant gefitinib in EGFR mutant NSCLC from ADJUVANT-CTONG 1104 trial.
Cunte Chen, Si-Yang Maggie Liu, +11 authors, Yangqiu Li.
JCI Insight, 2022 Jan 12; 7(1). PMID: 35014626    Free PMC article.
Follicular Helper T-Cell-Based Classification of Endometrial Cancer Promotes Precise Checkpoint Immunotherapy and Provides Prognostic Stratification.
Yi Chen, Shuwen You, +6 authors, Felix Haglund.
Front Immunol, 2022 Jan 25; 12. PMID: 35069566    Free PMC article.
Cancer Immunotherapy with Immune Checkpoint Inhibitors-Biomarkers of Response and Toxicity; Current Limitations and Future Promise.
Brian Healey Bird, Ken Nally, +5 authors, Stephen Finn.
Diagnostics (Basel), 2022 Jan 22; 12(1). PMID: 35054292    Free PMC article.
Review.
Immune Landscape Refines the Classification of Colorectal Cancer With Heterogeneous Prognosis, Tumor Microenvironment and Distinct Sensitivity to Frontline Therapies.
Zaoqu Liu, Yaxin Guo, +12 authors, Zhenqiang Sun.
Front Cell Dev Biol, 2022 Jan 28; 9. PMID: 35083217    Free PMC article.
Novel Molecular Determinants of Response or Resistance to Immune Checkpoint Inhibitor Therapies in Melanoma.
Wenjing Zhang, Yujia Kong, +5 authors, Qinghua Wang.
Front Immunol, 2022 Jan 29; 12. PMID: 35087523    Free PMC article.
Redox Metabolism-Associated Molecular Classification of Clear Cell Renal Cell Carcinoma.
Xiangling Wei, Weiming Deng, +9 authors, Ning Na.
Oxid Med Cell Longev, 2022 Feb 01; 2022. PMID: 35096270    Free PMC article.
Identification of KRAS G12V associated clonal neoantigens and immune microenvironment in long-term survival of pancreatic adenocarcinoma.
Chao Wang, Min Shi, +10 authors, Jun Zhang.
Cancer Immunol Immunother, 2021 Jul 14; 71(2). PMID: 34255132    Free PMC article.
An integrative multi-omics analysis based on liquid-liquid phase separation delineates distinct subtypes of lower-grade glioma and identifies a prognostic signature.
Jianglin Zheng, Zhipeng Wu, +2 authors, Xiaobing Jiang.
J Transl Med, 2022 Jan 31; 20(1). PMID: 35093128    Free PMC article.
Biomarkers for response to immune checkpoint inhibitors in gastrointestinal cancers.
Meng Li, Denis Kaili, Lei Shi.
World J Gastrointest Oncol, 2022 Feb 05; 14(1). PMID: 35116101    Free PMC article.
Review.
Association of PTPRT mutations with immune checkpoint inhibitors response and outcome in melanoma and non-small cell lung cancer.
Wenjing Zhang, Fuyan Shi, +4 authors, Qinghua Wang.
Cancer Med, 2021 Dec 05; 11(3). PMID: 34862763    Free PMC article.
Immunogenomic Landscape in Breast Cancer Reveals Immunotherapeutically Relevant Gene Signatures.
Tao Wang, Tianye Li, +14 authors, Xiaonan Zhang.
Front Immunol, 2022 Feb 15; 13. PMID: 35154121    Free PMC article.
Revealing Clonal Responses of Tumor-Reactive T-Cells Through T Cell Receptor Repertoire Analysis.
Hiroyasu Aoki, Shigeyuki Shichino, Kouji Matsushima, Satoshi Ueha.
Front Immunol, 2022 Feb 15; 13. PMID: 35154125    Free PMC article.
Review.
Intron-Retention Neoantigen Load Predicts Favorable Prognosis in Pancreatic Cancer.
Chuanpeng Dong, Jill L Reiter, +4 authors, Yunlong Liu.
JCO Clin Cancer Inform, 2022 Feb 12; 6. PMID: 35148169    Free PMC article.
Comprehensive analysis of N6-methyladenosine regulators with the tumor immune landscape and correlation between the insulin-like growth factor 2 mRNA-binding protein 3 and programmed death ligand 1 in bladder cancer.
Jianfeng Cui, Yaofeng Zhu, +6 authors, Benkang Shi.
Cancer Cell Int, 2022 Feb 13; 22(1). PMID: 35148766    Free PMC article.
Identification and Characterization of Immunogene-Related Alternative Splicing Patterns and Tumor Microenvironment Infiltration Patterns in Breast Cancer.
Shuang Guo, Xinyue Wang, +12 authors, Shangwei Ning.
Cancers (Basel), 2022 Feb 16; 14(3). PMID: 35158863    Free PMC article.
Myeloid antigen-presenting cell niches sustain antitumor T cells and license PD-1 blockade via CD28 costimulation.
Jaikumar Duraiswamy, Riccardo Turrini, +33 authors, George Coukos.
Cancer Cell, 2021 Nov 06; 39(12). PMID: 34739845    Free PMC article.
A DNA-Methylation-Driven Genes Based Prognostic Signature Reveals Immune Microenvironment in Pancreatic Cancer.
Mingjia Xiao, Xiangjing Liang, +9 authors, Yi Gao.
Front Immunol, 2022 Mar 01; 13. PMID: 35222383    Free PMC article.
Integratively Genomic Analysis Reveals the Prognostic and Immunological Characteristics of Pyroptosis and Ferroptosis in Pancreatic Cancer for Precision Immunotherapy.
Ting Yu, Huaicheng Tan, +4 authors, Huashan Shi.
Front Cell Dev Biol, 2022 Mar 05; 10. PMID: 35242763    Free PMC article.
Combined tumor and immune signals from genomes or transcriptomes predict outcomes of checkpoint inhibition in melanoma.
Samuel S Freeman, Moshe Sade-Feldman, +36 authors, Nir Hacohen.
Cell Rep Med, 2022 Mar 05; 3(2). PMID: 35243413    Free PMC article.
Immune-related lncRNA signature delineates an immune-excluded subtype of liver cancer with unfavorable clinical outcomes.
Yawei Chen, Leying Xi, +2 authors, Tianmei Zeng.
J Clin Lab Anal, 2022 Jan 19; 36(3). PMID: 35040184    Free PMC article.
Challenges of the Immunotherapy: Perspectives and Limitations of the Immune Checkpoint Inhibitor Treatment.
Paula Dobosz, Maria Stępień, Anna Golke, Tomasz Dzieciątkowski.
Int J Mol Sci, 2022 Mar 11; 23(5). PMID: 35269988    Free PMC article.
Review.
Integrated Analysis of Multi-Omics Alteration, Immune Profile, and Pharmacological Landscape of Pyroptosis-Derived lncRNA Pairs in Gastric Cancer.
Chunguang Guo, Zaoqu Liu, +11 authors, Zhen Li.
Front Cell Dev Biol, 2022 Mar 15; 10. PMID: 35281096    Free PMC article.
Determination of Breast Metabolic Phenotypes and Their Associations With Immunotherapy and Drug-Targeted Therapy: Analysis of Single-Cell and Bulk Sequences.
Ming Bai, Chen Sun.
Front Cell Dev Biol, 2022 Mar 15; 10. PMID: 35281118    Free PMC article.
Comprehensive Analysis of the PRDXs Family in Head and Neck Squamous Cell Carcinoma.
Ruoyan Cao, Weilin Zhang, +5 authors, Juan Xia.
Front Oncol, 2022 Mar 31; 12. PMID: 35350568    Free PMC article.
EGFR Mutation and 11q13 Amplification Are Potential Predictive Biomarkers for Immunotherapy in Head and Neck Squamous Cell Carcinoma.
Shengjin Dou, Lin Zhang, +9 authors, Guopei Zhu.
Front Immunol, 2022 Apr 05; 13. PMID: 35371031    Free PMC article.
The Role of m5C-Related lncRNAs in Predicting Overall Prognosis and Regulating the Lower Grade Glioma Microenvironment.
Hongshu Zhou, Ming Meng, +4 authors, Liyang Zhang.
Front Oncol, 2022 Apr 05; 12. PMID: 35372082    Free PMC article.
Deconvolving Clinically Relevant Cellular Immune Cross-talk from Bulk Gene Expression Using CODEFACS and LIRICS Stratifies Patients with Melanoma to Anti-PD-1 Therapy.
Kun Wang, Sushant Patkar, +6 authors, Eytan Ruppin.
Cancer Discov, 2022 Jan 06; 12(4). PMID: 34983745    Free PMC article.
Evaluation of the TCR Repertoire as a Predictive and Prognostic Biomarker in Cancer: Diversity or Clonality?
Andrea Aran, Laia Garrigós, +2 authors, Mercè Martí.
Cancers (Basel), 2022 Apr 13; 14(7). PMID: 35406543    Free PMC article.
Review.
Single-Cell Molecular Characterization to Partition the Human Glioblastoma Tumor Microenvironment Genetic Background.
Francesca Lessi, Sara Franceschi, +8 authors, Chiara Maria Mazzanti.
Cells, 2022 Apr 13; 11(7). PMID: 35406690    Free PMC article.
Prognostic Implications and Immune Infiltration Characteristics of Chromosomal Instability-Related Dysregulated CeRNA in Lung Adenocarcinoma.
Shengnan Guo, Tianhao Li, +9 authors, Kongning Li.
Front Mol Biosci, 2022 Apr 15; 9. PMID: 35419410    Free PMC article.
Endoscopic ultrasound-guided through-the-needle microforceps biopsy and needle-based confocal laser-endomicroscopy increase detection of potentially malignant pancreatic cystic lesions: A single-center study.
Carlos Robles-Medranda, Juan I Olmos, +7 authors, Hannah Pitanga-Lukashok.
World J Gastrointest Endosc, 2022 Apr 19; 14(3). PMID: 35432747    Free PMC article.
Subtyping of microsatellite stability colorectal cancer reveals guanylate binding protein 2 (GBP2) as a potential immunotherapeutic target.
Haizhou Wang, Yabo Zhou, +8 authors, Fan Wang.
J Immunother Cancer, 2022 Apr 07; 10(4). PMID: 35383115    Free PMC article.
A 2-Gene Signature Related to Interferon-Gamma Predicts Prognosis and Responsiveness to Immune Checkpoint Blockade of Glioma.
Yongzhe Li, Hang Ji, Xin Gao.
Front Med (Lausanne), 2022 May 03; 9. PMID: 35492352    Free PMC article.
A 13-Gene Signature Based on Estrogen Response Pathway for Predicting Survival and Immune Responses of Patients With UCEC.
Yimin Li, Ruotong Tian, +3 authors, Xiaodan Fu.
Front Mol Biosci, 2022 May 14; 9. PMID: 35558564    Free PMC article.
Sample-Specific Perturbation of Gene Interactions Identifies Pancreatic Cancer Subtypes.
Ran Wei, Huihui Zhang, +3 authors, Wuguo Deng.
Int J Mol Sci, 2022 May 15; 23(9). PMID: 35563183    Free PMC article.
Establishment of a lncRNA-Based Prognostic Gene Signature Associated With Altered Immune Responses in HCC.
Xiawei Li, Zhiqian Zhang, +5 authors, Jin-Tang Dong.
Front Immunol, 2022 May 17; 13. PMID: 35572559    Free PMC article.
Resistance mechanisms in melanoma to immuneoncologic therapy with checkpoint inhibitors.
Sarah E Fenton, Jeffrey A Sosman, Sunandana Chandra.
Cancer Drug Resist, 2019 Sep 19; 2(3). PMID: 35582566    Free PMC article.
Review.
Identification of AKIRIN2 as a potential biomarker and correlation with immunotherapy in gastric adenocarcinoma by integrated bioinformatics analysis.
Shaopeng Sun, Jiajia Chen, +3 authors, Bin Lv.
Sci Rep, 2022 May 20; 12(1). PMID: 35589807    Free PMC article.