Journal Article
. 2017 Mar;67(4).
doi: 10.3322/caac.21393.

Breast Cancer-Major changes in the American Joint Committee on Cancer eighth edition cancer staging manual

Armando E Giuliano 1 James L Connolly 2 Stephen B Edge 3 Elizabeth A Mittendorf 4 Hope S Rugo 5 Lawrence J Solin 6 Donald L Weaver 7 David J Winchester 8 Gabriel N Hortobagyi 9 
Affiliations
  • PMID: 28294295
  •     153 citations

Abstract

Answer questions and earn CME/CNE The revision of the eighth edition of the primary tumor, lymph node, and metastasis (TNM) classification of the American Joint Commission of Cancer (AJCC) for breast cancer was determined by a multidisciplinary team of breast cancer experts. The panel recognized the need to incorporate biologic factors, such as tumor grade, proliferation rate, estrogen and progesterone receptor expression, human epidermal growth factor 2 (HER2) expression, and gene expression prognostic panels into the staging system. AJCC levels of evidence and guidelines for all tumor types were followed as much as possible. The panel felt that, to maintain worldwide value, the tumor staging system should remain based on TNM anatomic factors. However, the recognition of the prognostic influence of grade, hormone receptor expression, and HER2 amplification mandated their inclusion into the staging system. The value of commercially available, gene-based assays was acknowledged and prognostic input added. Tumor biomarkers and low Oncotype DX recurrence scores can alter prognosis and stage. These updates are expected to provide additional precision and flexibility to the staging system and were based on the extent of published information and analysis of large, as yet unpublished databases. The eighth edition of the AJCC TNM staging system, thus, provides a flexible platform for prognostic classification based on traditional anatomic factors, which can be modified and enhanced using patient biomarkers and multifactorial prognostic panel data. The eighth edition remains the worldwide basis for breast cancer staging and will incorporate future online updates to remain timely and relevant. CA Cancer J Clin 2017;67:290-303. © 2017 American Cancer Society.

Keywords: biomarkers; distant metastases; ductal carcinoma in situ; estrogen receptor; human epidermal growth receptor 1 (HER2); infiltrating ductal carcinoma; infiltrating lobular carcinoma; lobular carcinoma in situ; lymph node metastases; neoadjuvant chemotherapy.

Incorporating Tumor Characteristics to the American Joint Committee on Cancer Breast Cancer Staging System.
Mariana Chavez-MacGregor, Elizabeth A Mittendorf, +3 authors, Sharon H Giordano.
Oncologist, 2017 Jun 09; 22(11). PMID: 28592619    Free PMC article.
The past and future of breast cancer treatment-from the papyrus to individualised treatment approaches.
Felipe Ades, Konstantinos Tryfonidis, Dimitrios Zardavas.
Ecancermedicalscience, 2017 Jul 12; 11. PMID: 28690677    Free PMC article.
Review.
A retrospective prognostic evaluation analysis using the 8th edition of American Joint Committee on Cancer (AJCC) cancer staging system for luminal A breast cancer.
Jingming Ye, Wenjun Wang, +7 authors, Yinhua Liu.
Chin J Cancer Res, 2017 Sep 28; 29(4). PMID: 28947867    Free PMC article.
Chemotherapy administration to breast cancer patients affects extracellular vesicles thrombogenicity and function.
Anat Aharon, Anni Sabbah, +4 authors, Gil Bar-Sela.
Oncotarget, 2017 Oct 04; 8(38). PMID: 28968987    Free PMC article.
Application of a novel prognostic invasive lesion index in ductal carcinoma in situ with minimal invasion of the breast.
Xiaofang He, Feng Ye, +4 authors, Xiaoming Xie.
Cancer Med, 2017 Oct 06; 6(11). PMID: 28980458    Free PMC article.
Gene Expression Profiling in Breast Cancer and Its Effect on Therapy Selection in Early-Stage Breast Cancer.
E Nilüfer Güler.
Eur J Breast Health, 2017 Oct 31; 13(4). PMID: 29082373    Free PMC article.
Review.
First Prospective Multicenter Italian Study on the Impact of the 21-Gene Recurrence Score in Adjuvant Clinical Decisions for Patients with ER Positive/HER2 Negative Breast Cancer.
Maria Vittoria Dieci, Valentina Guarneri, +15 authors, PierFranco Conte.
Oncologist, 2017 Nov 15; 23(3). PMID: 29133514    Free PMC article.
Histological Grading of Hepatocellular Carcinoma-A Systematic Review of Literature.
Sebastiao N Martins-Filho, Caterina Paiva, Raymundo Soares Azevedo, Venancio Avancini Ferreira Alves.
Front Med (Lausanne), 2017 Dec 07; 4. PMID: 29209611    Free PMC article.
Validation Study of the American Joint Committee on Cancer Eighth Edition Prognostic Stage Compared With the Anatomic Stage in Breast Cancer.
Anna Weiss, Mariana Chavez-MacGregor, +6 authors, Elizabeth A Mittendorf.
JAMA Oncol, 2017 Dec 10; 4(2). PMID: 29222540    Free PMC article.
The new TNM-based staging of breast cancer.
Gábor Cserni, Ewa Chmielik, Bálint Cserni, Tibor Tot.
Virchows Arch, 2018 Jan 31; 472(5). PMID: 29380126
Highly Cited. Review.
A retrospective prognostic evaluation analysis using the 8th edition of the American Joint Committee on Cancer staging system for breast cancer.
Sae Byul Lee, Guiyun Sohn, +6 authors, Sei-Hyun Ahn.
Breast Cancer Res Treat, 2018 Feb 02; 169(2). PMID: 29388016    Free PMC article.
The significance of tumour microarchitectural features in breast cancer prognosis: a digital image analysis.
I Roxanis, R Colling, +2 authors, E A Rakha.
Breast Cancer Res, 2018 Feb 07; 20(1). PMID: 29402299    Free PMC article.
Lobular Carcinoma In Situ.
Hannah Y Wen, Edi Brogi.
Surg Pathol Clin, 2018 Feb 08; 11(1). PMID: 29413653    Free PMC article.
Review.
Liquid Biopsy in Clinical Management of Breast, Lung, and Colorectal Cancer.
Ivana Bratić Hench, Jürgen Hench, Markus Tolnay.
Front Med (Lausanne), 2018 Feb 15; 5. PMID: 29441349    Free PMC article.
Highly Cited. Review.
A unique case of total metastatic lobular breast carcinoma, originating from diffused microcalcifications, presented in a postmenopausal woman, without clinical manifestations.
Athanasios Douskos, Aris Giannos, +5 authors, Alexandros Rodolakis.
Int J Surg Case Rep, 2018 Mar 04; 44. PMID: 29501020    Free PMC article.
The 21-Gene Recurrence Score in Male Breast Cancer.
Gulisa Turashvili, Monica Gonzalez-Loperena, +4 authors, Hannah Y Wen.
Ann Surg Oncol, 2018 Mar 10; 25(6). PMID: 29520654    Free PMC article.
Associations between genomic stratification of breast cancer and centrally reviewed tumour pathology in the METABRIC cohort.
A Mukherjee, R Russell, +9 authors, E Provenzano.
NPJ Breast Cancer, 2018 Mar 14; 4. PMID: 29532008    Free PMC article.
The prognostic value of circulating cell-free DNA in breast cancer: A meta-analysis.
Guoqiang Tan, Chang Chu, +2 authors, Qiufang Chen.
Medicine (Baltimore), 2018 Mar 30; 97(13). PMID: 29595655    Free PMC article.
Evidence-based approaches to reduce cancer health disparities: Discover, develop, deliver, and disseminate.
Priyanka P Desai, Jana B Lampe, +3 authors, Jamboor K Vishwanatha.
J Carcinog, 2018 Apr 13; 17. PMID: 29643743    Free PMC article.
Update on the Treatment of Early-Stage Triple-Negative Breast Cancer.
Priyanka Sharma.
Curr Treat Options Oncol, 2018 Apr 16; 19(5). PMID: 29656345
Review.
Long Non-Coding RNA TUG1 Expression Is Associated with Different Subtypes in Human Breast Cancer.
Daniela F Gradia, Carolina Mathias, +3 authors, Jaqueline C de Oliveira.
Noncoding RNA, 2018 Apr 17; 3(4). PMID: 29657297    Free PMC article.
Setup errors and effectiveness of Optical Laser 3D Surface imaging system (Sentinel) in postoperative radiotherapy of breast cancer.
Xiaobo Wei, Mengjiao Liu, +6 authors, Wendong Gu.
Sci Rep, 2018 May 10; 8(1). PMID: 29740104    Free PMC article.
Pure low-grade DCIS in a male patient: a case report.
Araya Zaesim, Viva Nguyen, Charles S Scarborough.
J Surg Case Rep, 2018 Jun 08; 2018(5). PMID: 29876051    Free PMC article.
Re-Evaluating E-Cadherin and β-Catenin: A Pan-Cancer Proteomic Approach with an Emphasis on Breast Cancer.
Nicholas Borcherding, Kimberly Cole, +4 authors, Weizhou Zhang.
Am J Pathol, 2018 Jun 08; 188(8). PMID: 29879416    Free PMC article.
Survival Comparisons Between Early Male and Female Breast Cancer Patients.
Kang Wang, Qiu-Juan Wang, +4 authors, Hong-Yuan Li.
Sci Rep, 2018 Jun 13; 8(1). PMID: 29891971    Free PMC article.
Impact of Micrometastatic Axillary Nodes on Survival of Breast Cancer Patients with Tumors ≤2 cm.
Hyeon Woo Bae, Kwang Hyun Yoon, +7 authors, Byeong-Woo Park.
World J Surg, 2018 Jul 01; 42(12). PMID: 29959491
Prognostic Validation of the American Joint Committee on Cancer 8th Staging System in 24,014 Korean Patients with Breast Cancer.
Isaac Kim, Hee Jun Choi, +5 authors, Jeong Eon Lee.
J Breast Cancer, 2018 Jul 03; 21(2). PMID: 29963113    Free PMC article.
Microinvasive Carcinoma versus Ductal Carcinoma In Situ: A Comparison of Clinicopathological Features and Clinical Outcomes.
Milim Kim, Hyun Jeong Kim, +7 authors, So Yeon Park.
J Breast Cancer, 2018 Jul 03; 21(2). PMID: 29963116    Free PMC article.
Gene expression assay and Watson for Oncology for optimization of treatment in ER-positive, HER2-negative breast cancer.
Yun Yeong Kim, Se Jeong Oh, +2 authors, Heung Kyu Park.
PLoS One, 2018 Jul 07; 13(7). PMID: 29979736    Free PMC article.
Personalizing Radiation Treatment Delivery in the Management of Breast Cancer.
Kamran A Ahmed, G Daniel Grass, +7 authors, Roberto Diaz.
Int J Breast Cancer, 2018 Jul 10; 2018. PMID: 29984003    Free PMC article.
Review.
Comprehensive integrated analysis of gene expression datasets identifies key anti-cancer targets in different stages of breast cancer.
Meng-Ting Gong, Shou-Dong Ye, +2 authors, Wen-Xing Li.
Exp Ther Med, 2018 Aug 17; 16(2). PMID: 30112036    Free PMC article.
Influence of age on radiomic features in 18F-FDG PET in normal breast tissue and in breast cancer tumors.
Sarah Boughdad, Christophe Nioche, +3 authors, Irène Buvat.
Oncotarget, 2018 Aug 17; 9(56). PMID: 30112113    Free PMC article.
Development and Validation of Nomograms for Predicting Overall and Breast Cancer-Specific Survival in Young Women with Breast Cancer: A Population-Based Study.
Yue Gong, Peng Ji, +3 authors, Zhi-Ming Shao.
Transl Oncol, 2018 Sep 07; 11(6). PMID: 30189361    Free PMC article.
Immunoexpression of claudins 4 and 7 among invasive breast carcinoma subtypes: A large diagnostic study using tissue microarray.
Angela Flávia Logullo, Fatima Solange Pasini, +3 authors, Maria Mitzi Brentani.
Mol Clin Oncol, 2018 Sep 15; 9(4). PMID: 30214726    Free PMC article.
An Update on Breast Cancer Multigene Prognostic Tests-Emergent Clinical Biomarkers.
André Filipe Vieira, Fernando Schmitt.
Front Med (Lausanne), 2018 Sep 21; 5. PMID: 30234119    Free PMC article.
Review.
An Italian Delphi study to evaluate consensus on adjuvant endocrine therapy in premenopausal patients with breast cancer: the ERA project.
Giacomo Pelizzari, Grazia Arpino, +8 authors, Fabio Puglisi.
BMC Cancer, 2018 Sep 29; 18(1). PMID: 30261866    Free PMC article.
Evaluating the Prediction of Breast Cancer Survival Using Lymph Node Ratio.
Man Hung, Julie Xu, +4 authors, Maren Wright Voss.
J Breast Cancer, 2018 Oct 03; 21(3). PMID: 30275860    Free PMC article.
Meta-analysis of the likelihood of FOXC2 expression in early- and late-stage tumors.
Tsutomu Kume, Tarek Shackour.
Oncotarget, 2018 Oct 04; 9(70). PMID: 30279969    Free PMC article.
Clinical implication of subcategorizing T2 category into T2a and T2b in TNM staging of breast cancer.
Jiwoong Jung, Young Jin Suh, +5 authors, Ki-Tae Hwang.
Cancer Med, 2018 Oct 13; 7(11). PMID: 30311421    Free PMC article.
Predicting the response to neoadjuvant therapy for early-stage breast cancer: tumor-, blood-, and imaging-related biomarkers.
Wenyong Tan, Ming Yang, +2 authors, Weixi Shen.
Cancer Manag Res, 2018 Oct 24; 10. PMID: 30349367    Free PMC article.
Review.
Expression of the CD59 Glycoprotein Precursor is Upregulated in an Estrogen Receptor-alpha (ER-α)-Negative and a Tamoxifen-Resistant Breast Cancer Cell Line In Vitro.
Huiru Xiong, Xiaowei Jin, Chuanwen You.
Med Sci Monit, 2018 Nov 06; 24. PMID: 30391994    Free PMC article.
Development and validation of nomograms for predicting overall and breast cancer-specific survival among patients with triple-negative breast cancer.
Lin-Wei Guo, Lin-Miao Jiang, +6 authors, Xin Hu.
Cancer Manag Res, 2018 Dec 05; 10. PMID: 30510456    Free PMC article.
Evaluation of the Incorporation of Recurrence Score into the American Joint Committee on Cancer Eighth Edition Staging System in Patients with T1-2N0M0, Estrogen Receptor-Positive, Human Epidermal Growth Receptor 2-Negative Invasive Breast Cancer: A Population-Based Analysis.
Shuning Ding, Jiayi Wu, +6 authors, Li Zhu.
Oncologist, 2019 Apr 26; 24(11). PMID: 31019021    Free PMC article.
Risk of Positive Sentinel Lymph Node After Neoadjuvant Systemic Therapy in Clinically Node-Negative Breast Cancer: Implications for Postmastectomy Radiation Therapy and Immediate Breast Reconstruction.
S Samiei, B N van Kaathoven, +9 authors, T J A van Nijnatten.
Ann Surg Oncol, 2019 Jul 31; 26(12). PMID: 31359276    Free PMC article.
Changing patterns and survival improvements of young breast cancer in China and SEER database, 1999-2017.
Rong Guo, Jing Si, +7 authors, Jiong Wu.
Chin J Cancer Res, 2019 Oct 01; 31(4). PMID: 31564808    Free PMC article.
Hsa-miR-210-3p expression in breast cancer and its putative association with worse outcome in patients treated with Docetaxel.
Barbara Pasculli, Raffaela Barbano, +11 authors, Paola Parrella.
Sci Rep, 2019 Oct 19; 9(1). PMID: 31624308    Free PMC article.
Pretreatment identification of micro-metastasis in mediastinal lymph node by endobronchial ultrasound-guided transbronchial needle aspiration for early-stage non-small cell lung cancer-is it time yet?
Abhishek Biswas, Michael A Jantz, Hiren J Mehta.
J Thorac Dis, 2019 Nov 19; 11(10). PMID: 31737291    Free PMC article.
Long non-coding RNA heart and neural crest derivatives expressed 2-antisense RNA 1 overexpression inhibits the proliferation of cancer cells by reducing RUNX2 expression in triple-negative breast cancer.
Min Wei, Lei Liu, Zhiwei Wang.
Oncol Lett, 2019 Dec 04; 18(6). PMID: 31788122    Free PMC article.
Proposal for a Histological Staging System of Mammary Carcinomas in Dogs and Cats. Part 1: Canine Mammary Carcinomas.
Florian Chocteau, Jérôme Abadie, Delphine Loussouarn, Frédérique Nguyen.
Front Vet Sci, 2019 Dec 04; 6. PMID: 31788485    Free PMC article.
Validation of the AJCC prognostic stage for HER2-positive breast cancer in the ShortHER trial.
Maria Vittoria Dieci, Giancarlo Bisagni, +29 authors, Pier Franco Conte.
BMC Med, 2019 Nov 22; 17(1). PMID: 31747948    Free PMC article.
Assessment of kidney transplant suitability for patients with prior cancers: is it time for a rethink?
Wai H Lim, Eric Au, Anoushka Krishnan, Germaine Wong.
Transpl Int, 2019 Aug 07; 32(12). PMID: 31385629    Free PMC article.
Review.
The diagnostic accuracy of magnetic resonance imaging in predicting pathologic complete response after neoadjuvant chemotherapy in patients with different molecular subtypes of breast cancer.
Xinfeng Zhang, Dandan Wang, +6 authors, Feng Jin.
Quant Imaging Med Surg, 2020 Jan 21; 10(1). PMID: 31956542    Free PMC article.
Preoperative Delays in the Treatment of DCIS and the Associated Incidence of Invasive Breast Cancer.
William H Ward, Lyudmila DeMora, +5 authors, Richard J Bleicher.
Ann Surg Oncol, 2019 Sep 29; 27(2). PMID: 31562602    Free PMC article.
Identification of miRNA-Based Signature as a Novel Potential Prognostic Biomarker in Patients with Breast Cancer.
Jia Tang, Wei Ma, +3 authors, Liangping Luo.
Dis Markers, 2020 Jan 25; 2019. PMID: 31976020    Free PMC article.
The effect of metformin on biomarkers associated with breast cancer outcomes: a systematic review, meta-analysis, and dose-response of randomized clinical trials.
J Rahmani, N Manzari, +7 authors, Y Zhang.
Clin Transl Oncol, 2019 Apr 23; 22(1). PMID: 31006835
Systematic Review.
Breast Cancer Recurrence Risk Assessment: Is Non-Invasive Monitoring an Option?
Elisa M Schunkert, Wanzhou Zhao, Kurt Zänker.
Biomed Hub, 2018 Nov 01; 3(3). PMID: 31988964    Free PMC article.
Review.
Visceral fat metabolic activity evaluated by preoperative 18F-FDG PET/CT significantly affects axillary lymph node metastasis in postmenopausal luminal breast cancer.
Kisoo Pahk, Chanmin Joung, Sungeun Kim.
Sci Rep, 2020 Jan 30; 10(1). PMID: 31992764    Free PMC article.
Preoperative assessment of contrast-enhanced spectral mammography of diagnosed breast cancers after sonographic biopsy: Correlation to contrast-enhanced magnetic resonance imaging and 5-year postoperative follow-up.
Yun-Chung Cheung, Yu-Hsiang Juan, +3 authors, Shir-Hwa Ueng.
Medicine (Baltimore), 2020 Feb 01; 99(5). PMID: 32000448    Free PMC article.
Lymph Node Imaging in Patients with Primary Breast Cancer: Concurrent Diagnostic Tools.
Maria Adele Marino, Daly Avendano, +2 authors, Katja Pinker.
Oncologist, 2020 Feb 12; 25(2). PMID: 32043792    Free PMC article.
Review.
Deep Learning vs. Radiomics for Predicting Axillary Lymph Node Metastasis of Breast Cancer Using Ultrasound Images: Don't Forget the Peritumoral Region.
Qiuchang Sun, Xiaona Lin, +5 authors, Zhi-Cheng Li.
Front Oncol, 2020 Feb 23; 10. PMID: 32083007    Free PMC article.
Definition of Internal Mammary Node Target Volume Based on the Position of the Internal Mammary Sentinel Lymph Nodes Presented on SPECT/CT Fusion Images.
Xue Wang, Wei Wang, +6 authors, Jin-Zhi Wang.
Front Oncol, 2020 Feb 23; 9. PMID: 32083014    Free PMC article.
Bayesian and Frequentist Analytical Approaches Using Log-Normal and Gamma Frailty Parametric Models for Breast Cancer Mortality.
Refah Mohammed Alotaibi, Chris Guure.
Comput Math Methods Med, 2020 Feb 25; 2020. PMID: 32089731    Free PMC article.
Impact of New Technology Adoption on Breast Cancer Screening.
Christoph I Lee, Janie M Lee.
Radiology, 2018 Dec 12; 290(3). PMID: 30526355    Free PMC article.
Attenuated Total Reflection-Fourier Transform Infrared (ATR-FTIR) Spectroscopy Analysis of Saliva for Breast Cancer Diagnosis.
Izabella C C Ferreira, Emília M G Aguiar, +7 authors, Yara C P Maia.
J Oncol, 2020 Feb 28; 2020. PMID: 32104176    Free PMC article.
Assessment of the Prognostic Staging System of American Joint Committee on Cancer 8th Edition for Breast Cancer: Comparisons with the Conventional Anatomic Staging System.
Eun Jin Kim, Hyung Seok Park, +3 authors, Byeong-Woo Park.
J Breast Cancer, 2020 Mar 07; 23(1). PMID: 32140270    Free PMC article.
The Clinical Significance of Breast-only and Node-only Pathologic Complete Response (pCR) After Neoadjuvant Chemotherapy (NACT): A Review of 20,000 Breast Cancer Patients in the National Cancer Data Base (NCDB).
Oluwadamilola M Fayanju, Yi Ren, +8 authors, E Shelley Hwang.
Ann Surg, 2018 Jul 27; 268(4). PMID: 30048319    Free PMC article.
Impact of Genomic Assay Testing and Clinical Factors on Chemotherapy Use After Implementation of Standardized Testing Criteria.
Kelsey H Natsuhara, Katya Losk, +7 authors, Rachel A Freedman.
Oncologist, 2018 Aug 05; 24(5). PMID: 30076279    Free PMC article.
Integrative 3' Untranslated Region-Based Model to Identify Patients with Low Risk of Axillary Lymph Node Metastasis in Operable Triple-Negative Breast Cancer.
Lei Wang, Xin Hu, Peng Wang, Zhi-Ming Shao.
Oncologist, 2018 Aug 08; 24(1). PMID: 30082491    Free PMC article.
Implications for Breast Cancer Restaging Based on the 8th Edition AJCC Staging Manual.
Jennifer K Plichta, Yi Ren, +5 authors, E Shelley Hwang.
Ann Surg, 2018 Oct 13; 271(1). PMID: 30312199    Free PMC article.
Community clinical practice patterns and mortality in patients with intermediate oncotype DX recurrence scores: Who benefits from chemotherapy?
Abiola F Ibraheem, David J Press, Olufunmilayo I Olopade, Dezheng Huo.
Cancer, 2018 Nov 06; 125(2). PMID: 30387876    Free PMC article.
Identification of a 4-mRNA metastasis-related prognostic signature for patients with breast cancer.
Xinhua Xie, Jianwei Wang, +6 authors, Xiaoming Xie.
J Cell Mol Med, 2018 Nov 30; 23(2). PMID: 30484951    Free PMC article.
Development and validation of nomograms integrating immune-related genomic signatures with clinicopathologic features to improve prognosis and predictive value of triple-negative breast cancer: A gene expression-based retrospective study.
Kang Wang, Hai-Lin Li, +5 authors, Hong-Yuan Li.
Cancer Med, 2019 Jan 25; 8(2). PMID: 30677255    Free PMC article.
Patterns of Care and Efficacy of Chemotherapy and Radiotherapy in Skin-Involved Breast Cancers of All Sizes.
Alina M Mateo, Anna M Mazor, +7 authors, Richard J Bleicher.
Clin Breast Cancer, 2019 Mar 16; 19(4). PMID: 30871966    Free PMC article.
Pyridoxine 5'-phosphate oxidase is correlated with human breast invasive ductal carcinoma development.
Weimin Ren, Wencai Guan, +2 authors, Guoxiong Xu.
Aging (Albany NY), 2019 Apr 16; 11(7). PMID: 30982780    Free PMC article.
Surgery of the Primary Tumor Offers Survival Benefits of Breast Cancer with Synchronous Ipsilateral Supraclavicular Lymph Node Metastasis.
Qi-Tong Chen, Li-Yun Zeng, +5 authors, Wen-Jun Yi.
World J Surg, 2019 Nov 28; 44(4). PMID: 31773219
Rapid progression of carcinoma en cuirasse breast dermal metastases on 18F-fludeoxyglucose positron emission tomography-computed tomography.
Colin Raymond Young, Mallini Harigopal, Darko Pucar.
World J Nucl Med, 2020 Mar 20; 19(1). PMID: 32190027    Free PMC article.
The subgross morphology of breast carcinomas: a single-institution series of 2033 consecutive cases documented in large-format histology slides.
Tibor Tot, Maria Gere, +2 authors, Ulrika Pellas.
Virchows Arch, 2019 Aug 15; 476(3). PMID: 31410558
A bioinformatics approach to identify novel long, non-coding RNAs in breast cancer cell lines from an existing RNA-sequencing dataset.
Oza Zaheed, Julia Samson, Kellie Dean.
Noncoding RNA Res, 2020 Mar 25; 5(2). PMID: 32206740    Free PMC article.
Inappropriate modeling of chronic and complex disorders: How to reconsider the approach in the context of predictive, preventive and personalized medicine, and translational medicine.
Soroush Seifirad, Vahid Haghpanah.
EPMA J, 2019 Aug 30; 10(3). PMID: 31462938    Free PMC article.
Biological subtype predicts locoregional recurrence after postmastectomy radiotherapy in Chinese breast cancer patients.
Jiangfeng Wang, Jurui Luo, +9 authors, Xiaomao Guo.
Cancer Med, 2020 Feb 13; 9(7). PMID: 32048817    Free PMC article.
Genetic 3'UTR variations and clinical factors significantly contribute to survival prediction and clinical response in breast cancer patients.
Jolanta Pamuła-Piłat, Karolina Tęcza, Magdalena Kalinowska-Herok, Ewa Grzybowska.
Sci Rep, 2020 Apr 03; 10(1). PMID: 32235849    Free PMC article.
A qualitative transcriptional signature to reclassify histological grade of ER-positive breast cancer patients.
Jing Li, Wenbin Jiang, +6 authors, Guo Zheng.
BMC Genomics, 2020 Apr 08; 21(1). PMID: 32252627    Free PMC article.
Benefits of adjuvant treatment including trastuzumab in HER2-positive pT1a-bN0M0 breast cancer: a systematic review and meta-analysis.
Hye Yoon Lee, In-Soo Shin, Chai Hong Rim.
Ann Transl Med, 2020 Apr 21; 8(5). PMID: 32309334    Free PMC article.
High SET Domain Bifurcated 1 (SETDB1) Expression Predicts Poor Prognosis in Breast Carcinoma.
Zhaoping Zhou, Baojin Wu, +3 authors, Hongying Wang.
Med Sci Monit, 2020 Apr 20; 26. PMID: 32305991    Free PMC article.
Validation of the 8th edition of the American Joint Committee on Cancer Pathological Prognostic Staging for young breast cancer patients.
Juan Zhou, Jian Lei, +4 authors, San-Gang Wu.
Aging (Albany NY), 2020 Apr 23; 12(8). PMID: 32320950    Free PMC article.
Proton MR spectroscopy in the breast: Technical innovations and clinical applications.
Reza Fardanesh, Maria Adele Marino, +3 authors, Sunitha B Thakur.
J Magn Reson Imaging, 2019 Mar 09; 50(4). PMID: 30848037    Free PMC article.
Review.
The study of internal mammary lymph node dissection guided by modified radiotracer injection technique in breast cancer-a case report and review.
Zhao Bi, Peng Chen, Xian-Rang Song, Yong-Sheng Wang.
Gland Surg, 2020 May 19; 9(2). PMID: 32420269    Free PMC article.
21-Gene Recurrence Score Adds Significant Value for Grade 3 Breast Cancers: Results From a National Cohort.
J Bryan Iorgulescu, Rachel A Freedman, +2 authors, Jane E Brock.
JCO Precis Oncol, 2019 Jan 01; 3. PMID: 32457931    Free PMC article.
Prognostic validation and therapeutic decision-making of the AJCC eighth pathological prognostic staging for T3N0 breast cancer after mastectomy.
San-Gang Wu, Jun Wang, +4 authors, Zhen-Yu He.
Clin Transl Med, 2020 Jun 09; 10(1). PMID: 32508053    Free PMC article.
A subset of activated fibroblasts is associated with distant relapse in early luminal breast cancer.
Claire Bonneau, Antoine Eliès, +9 authors, Fatima Mechta-Grigoriou.
Breast Cancer Res, 2020 Jul 16; 22(1). PMID: 32665033    Free PMC article.
Predicting Upstaging of DCIS to Invasive Disease: Radiologists's Predictive Performance.
Vignesh Selvakumaran, Rui Hou, +11 authors, Lars J Grimm.
Acad Radiol, 2020 Feb 01; 27(11). PMID: 32001164    Free PMC article.
Correlation between salivary and serum CA15-3 concentrations in patients with breast cancer.
Daniele Xavier Assad, Elisa Cançado Porto Mascarenhas, +6 authors, Eliete Neves Silva Guerra.
Mol Clin Oncol, 2020 Jul 28; 13(2). PMID: 32714539    Free PMC article.
Evaluation of the 8th edition of the American joint committee on cancer's pathological staging system in prognosis assessment and treatment decision making for stage T1-2N1 breast cancer after mastectomy.
San-Gang Wu, Jun Wang, +5 authors, Zhen-Yu He.
Breast, 2020 Mar 17; 51. PMID: 32172191    Free PMC article.
Prospective observational study on the impact of the 21-gene assay on treatment decisions and resources optimization in breast cancer patients in Lombardy: The BONDX study.
Alberto Zambelli, Edda Simoncini, +11 authors, Carlo Tondini.
Breast, 2020 Apr 24; 52. PMID: 32325372    Free PMC article.
Overview of Breast Cancer and Implications of Overtreatment of Early-Stage Breast Cancer: An Indian Perspective.
Gouri Shankar Bhattacharyya, Dinesh C Doval, +3 authors, S P Somashekhar.
JCO Glob Oncol, 2020 Jun 09; 6. PMID: 32511068    Free PMC article.
Clinical decision trees support systematic evaluation of multidisciplinary team recommendations.
Mathijs P Hendriks, Xander A A M Verbeek, +6 authors, Agnes Jager.
Breast Cancer Res Treat, 2020 Jul 07; 183(2). PMID: 32627108    Free PMC article.
Multidetector Computed Tomography with Dedicated Protocol for Breast Cancer Locoregional Staging: Feasibility Study.
Vinicius C Felipe, Luciana Graziano, +2 authors, Almir G V Bitencourt.
Diagnostics (Basel), 2020 Jul 18; 10(7). PMID: 32674511    Free PMC article.
Propensity score analysis of the prognostic value of genomic assays for breast cancer in diverse populations using the National Cancer Data Base.
Abiola Ibraheem, Olufunmilayo I Olopade, Dezheng Huo.
Cancer, 2020 Jun 11; 126(17). PMID: 32521056    Free PMC article.
Comprehensive analysis of autophagy-related prognostic genes in breast cancer.
Jianguo Lai, Bo Chen, +3 authors, Ning Liao.
J Cell Mol Med, 2020 Jul 04; 24(16). PMID: 32618109    Free PMC article.
Association Between Time to Operation and Pathologic Stage in Ductal Carcinoma in Situ and Early-Stage Hormone Receptor-Positive Breast Cancer.
Christina A Minami, Olga Kantor, +3 authors, Elizabeth A Mittendorf.
J Am Coll Surg, 2020 Aug 11; 231(4). PMID: 32771654    Free PMC article.
Combining node location and node ratio as a prognostic factor for surgical resected non-small cell lung cancer: a population-based study.
Huajie Xing, Mengyu Hu, +3 authors, Chaoyang Liang.
J Thorac Dis, 2020 Aug 18; 12(7). PMID: 32802434    Free PMC article.
Prognostic validation and treatment decision making of the 8th edition of the American Joint Committee on Cancer pathological staging system for elderly women with early-stage breast cancer.
San-Gang Wu, Jian Shi, +6 authors, Zhen-Yu He.
Aging (Albany NY), 2020 Jul 28; 12(14). PMID: 32710731    Free PMC article.
Silencing DSCAM-AS1 suppresses the growth and invasion of ER-positive breast cancer cells by downregulating both DCTPP1 and QPRT.
Zhang Yue, Jia Shusheng, +5 authors, Huang Yuanxi.
Aging (Albany NY), 2020 Jul 28; 12(14). PMID: 32716908    Free PMC article.
Identification of a Six-lncRNA Signature With Prognostic Value for Breast Cancer Patients.
Erjie Zhao, Yujia Lan, +5 authors, Jing Hu.
Front Genet, 2020 Aug 28; 11. PMID: 32849766    Free PMC article.
Phyto-Immunotherapy, a Complementary Therapeutic Option to Decrease Metastasis and Attack Breast Cancer Stem Cells.
Susana Fiorentino, Claudia Urueña, +2 authors, Alfonso Barreto.
Front Oncol, 2020 Aug 28; 10. PMID: 32850424    Free PMC article.
Review.
An Intelligent Decision-Making Support System for the Detection and Staging of Prostate Cancer in Developing Countries.
Jun Zhang, Zhigang Chen, Jia Wu, Kanghuai Liu.
Comput Math Methods Med, 2020 Sep 04; 2020. PMID: 32879636    Free PMC article.
The Breast Health Global Initiative 2018 Global Summit on Improving Breast Healthcare Through Resource-Stratified Phased Implementation: Methods and overview.
Catherine Duggan, Allison Dvaladze, +13 authors, Benjamin O Anderson.
Cancer, 2020 Apr 30; 126 Suppl 10. PMID: 32348573    Free PMC article.
Radiological Society of North America (RSNA) 3D printing Special Interest Group (SIG): guidelines for medical 3D printing and appropriateness for clinical scenarios.
Leonid Chepelev, Nicole Wake, +16 authors, RSNA Special Interest Group for 3D Printing.
3D Print Med, 2019 Jan 17; 4(1). PMID: 30649688    Free PMC article.
Highly Cited.
Examination of the Biomark assay as an alternative to Oncotype DX for defining chemotherapy benefit.
Jinkyoung Kim, Aeree Kim, Chungyeul Kim.
Oncol Lett, 2019 Jan 25; 17(2). PMID: 30675242    Free PMC article.
Ginsenoside Rg3: Potential Molecular Targets and Therapeutic Indication in Metastatic Breast Cancer.
Maryam Nakhjavani, Jennifer E Hardingham, +4 authors, Amanda R Townsend.
Medicines (Basel), 2019 Jan 27; 6(1). PMID: 30678106    Free PMC article.
Review.
Analysis of Hormone Receptor Status in Primary and Recurrent Breast Cancer Via Data Mining Pathology Reports.
Kai-Po Chang, Yen-Wei Chu, John Wang.
Open Med (Wars), 2019 Mar 09; 14. PMID: 30847396    Free PMC article.
Comparison of the 7th and 8th edition of American Joint Committee on Cancer (AJCC) staging systems for breast cancer patients: a Surveillance, Epidemiology and End Results (SEER) Analysis.
Nan Shao, Chuanbo Xie, +6 authors, Ying Lin.
Cancer Manag Res, 2019 Mar 14; 11. PMID: 30863154    Free PMC article.
Estrogen receptor variants in ER-positive basal-type breast cancers responding to therapy like ER-negative breast cancers.
Floris H Groenendijk, Tina Treece, +6 authors, Pat Whitworth.
NPJ Breast Cancer, 2019 Apr 25; 5. PMID: 31016233    Free PMC article.
Anatomy is not enough: the crucial role of biology and genetics in AJCC eighth edition of the TNM classification for breast cancer.
Francesca Magnoni, Giuseppe Accardo, +2 authors, Giovanni Corso.
Ann Transl Med, 2019 Apr 30; 7(Suppl 1). PMID: 31032313    Free PMC article.
The Effect of the New Eighth Edition Breast Cancer Staging System on 100 Consecutive Patients.
Ashley Biswal, Jacqueline Erler, +6 authors, Denise Johnson Miller.
J Clin Med Res, 2019 May 31; 11(6). PMID: 31143307    Free PMC article.
Should a Multigene Signature be Used in all Luminal Early Breast Cancers.
Nawale Hajjaji, Yves Marie Robin, Jacques Bonneterre.
Front Oncol, 2019 Jun 20; 9. PMID: 31214499    Free PMC article.
High expression of metabolic enzyme PFKFB4 is associated with poor prognosis of operable breast cancer.
Ling Yao, Lei Wang, +2 authors, Zhi-Ming Shao.
Cancer Cell Int, 2019 Jun 28; 19. PMID: 31244553    Free PMC article.
Validation of a Risk Score Incorporating Tumor Characteristics into the American Joint Committee on Cancer Anatomic Stage for Breast Cancer.
Yi Heng Seow, Ru Xin Wong, +3 authors, Fuh Yong Wong.
J Breast Cancer, 2019 Jul 10; 22(2). PMID: 31281728    Free PMC article.
Cytological Correlates of Axillary Nodal Involvement in Invasive Ductal Carcinoma of Breast.
Anamika Sinha, Satyajit Singh Gill.
J Cytol, 2019 Jul 31; 36(3). PMID: 31359912    Free PMC article.
Association of ki67 and tumor marker p53 in locally advanced breast cancer patients and evaluation of response to neoadjuvant chemotherapy: a survey in South Iran.
Dena Firouzabadi, Alireza Rezvani, Amirreza Dehghanian, Laleh Mahmoudi.
Cancer Manag Res, 2019 Aug 03; 11. PMID: 31372050    Free PMC article.
Comparison of GenesWell BCT Score With Oncotype DX Recurrence Score for Risk Classification in Asian Women With Hormone Receptor-Positive, HER2-Negative Early Breast Cancer.
Mi Jeong Kwon, Jeong Eon Lee, +12 authors, Young Kee Shin.
Front Oncol, 2019 Aug 14; 9. PMID: 31404265    Free PMC article.
MicroRNA-16 sensitizes drug-resistant breast cancer cells to Adriamycin by targeting Wip1 and Bcl-2.
Xitao Gao, Mei Wang, +3 authors, Jinhai Tang.
Oncol Lett, 2019 Aug 28; 18(3). PMID: 31452770    Free PMC article.
High WDR34 mRNA expression as a potential prognostic biomarker in patients with breast cancer as determined by integrated bioinformatics analysis.
Dao-Jun Hu, Wen-Jie Shi, Miao Yu, Li Zhang.
Oncol Lett, 2019 Aug 28; 18(3). PMID: 31452794    Free PMC article.
Dynamic and subtype-specific interactions between tumour burden and prognosis in breast cancer.
S B Lee, H-K Kim, +13 authors, H-G Moon.
Sci Rep, 2020 Sep 24; 10(1). PMID: 32963275    Free PMC article.
Diagnostic Performance of Indocyanine Green Plus Methylene Blue Versus Radioisotope Plus Methylene Blue Dye Method for Sentinel Lymph Node Biopsy in Node-Negative Early Breast Cancer.
Sanjit Kumar Agrawal, Izideen Hashlamoun, +3 authors, Rosina Ahmed.
JCO Glob Oncol, 2020 Aug 05; 6. PMID: 32749861    Free PMC article.
The comparison of the anatomic stage and pathological prognostic stage according to the AJCC 8th edition for the prognosis in Japanese breast cancer patients: data from a single institution.
Eriko Tokunaga, Hideki Ijichi, +9 authors, Masahiro Okamoto.
Breast Cancer, 2020 May 31; 27(6). PMID: 32472474    Free PMC article.
Quantitative ultrasound radiomics using texture derivatives in prediction of treatment response to neo-adjuvant chemotherapy for locally advanced breast cancer.
Archya Dasgupta, Stephen Brade, +14 authors, Gregory J Czarnota.
Oncotarget, 2020 Nov 05; 11(42). PMID: 33144919    Free PMC article.
Triple‑negative breast cancer therapy: Current and future perspectives (Review).
Kwang-Ai Won, Charles Spruck.
Int J Oncol, 2020 Nov 12; 57(6). PMID: 33174058    Free PMC article.
Establishing a predicted model to evaluate prognosis for initially diagnosed metastatic Her2-positive breast cancer patients and exploring the benefit from local surgery.
Hong Lin, Yanxuan Wu, Guoxi Liang, Liming Chen.
PLoS One, 2020 Nov 11; 15(11). PMID: 33170907    Free PMC article.
How to Predict Metastasis in Luminal Breast Cancer? Current Solutions and Future Prospects.
Sylwia Tabor, Małgorzata Szostakowska-Rodzos, Anna Fabisiewicz, Ewa A Grzybowska.
Int J Mol Sci, 2020 Nov 14; 21(21). PMID: 33182512    Free PMC article.
Review.
Combined Therapy Can Improve the Outcomes of Breast Cancer with Isolated Supraclavicular Lymph Node Involvement.
Tianyi Ma, Yan Mao, Haibo Wang.
Cancer Manag Res, 2020 Nov 27; 12. PMID: 33239916    Free PMC article.
Internal mammary sentinel lymph node biopsy with modified injection technique: A case report.
Zhao Bi, Wei-Zhen Zheng, +3 authors, Yong-Sheng Wang.
Medicine (Baltimore), 2018 Feb 01; 96(52). PMID: 29384935    Free PMC article.
Omitting Adjuvant Radiotherapy for Hormone Receptor‒Positive Early-Stage Breast Cancer in Old Age: A Propensity Score Matched SEER Analysis.
Yi-Jun Kim, Kyung Hwan Shin, Kyubo Kim.
Cancer Res Treat, 2018 May 12; 51(1). PMID: 29747486    Free PMC article.
Multifocal/Multicentric Ipsilateral Invasive Breast Carcinomas with Similar Histology: Is Multigene Testing of All Individual Foci Necessary?
Anne Grabenstetter, Edi Brogi, +4 authors, Hannah Y Wen.
Ann Surg Oncol, 2018 Oct 10; 26(2). PMID: 30298311    Free PMC article.
Validation of the pathological prognostic staging system proposed in the revised eighth edition of the AJCC staging manual in different molecular subtypes of breast cancer.
Nuri Jang, Jung Eun Choi, Su Hwan Kang, Young Kyung Bae.
Virchows Arch, 2018 Nov 27; 474(2). PMID: 30474738
Next-generation sequencing-based clinical sequencing: toward precision medicine in solid tumors.
Toshifumi Wakai, Pankaj Prasoon, +3 authors, Masayuki Nagahashi.
Int J Clin Oncol, 2018 Dec 06; 24(2). PMID: 30515675
Review.
Meta-analysis of the likelihood of FOXC1 expression in early- and late-stage tumors.
Tsutomu Kume, Tarek Shackour.
Oncotarget, 2018 Dec 20; 9(93). PMID: 30564302    Free PMC article.
The composition of T cell infiltrates varies in primary invasive breast cancer of different molecular subtypes as well as according to tumor size and nodal status.
Anna Glajcar, Joanna Szpor, +2 authors, Krzysztof Okoń.
Virchows Arch, 2019 Apr 25; 475(1). PMID: 31016433    Free PMC article.
Performance of a new system using a one-step nucleic acid amplification assay for detecting lymph node metastases in breast cancer.
Kenzo Shimazu, Tomonori Tanei, +7 authors, Shinzaburo Noguchi.
Med Oncol, 2019 May 08; 36(6). PMID: 31062258
First Intraoperative Radiation Therapy Center in Africa: First 2 Years in Operation, Including COVID-19 Experiences.
Yastira Ramdas, Carol-Ann Benn, Michelle van Heerden.
JCO Glob Oncol, 2020 Nov 07; 6. PMID: 33156717    Free PMC article.
Mechanisms of Resistance to Chemotherapy in Breast Cancer and Possible Targets in Drug Delivery Systems.
Patrícia de Faria Lainetti, Antonio Fernando Leis-Filho, +2 authors, Carlos Eduardo Fonseca-Alves.
Pharmaceutics, 2020 Dec 16; 12(12). PMID: 33316872    Free PMC article.
Review.
Prognostic and Predictive Value of the American Joint Committee on Cancer Pathological Prognostic Staging System in Nodal Micrometastatic Breast Cancer.
Jian Shi, Chen-Lu Lian, +6 authors, San-Gang Wu.
Front Oncol, 2021 Jan 05; 10. PMID: 33392071    Free PMC article.
Predictive Value of CD44 for Prognosis in Patients with Breast Cancer.
Yousef Roosta, Zohreh Sanaat, +2 authors, Ashraf Fakhrjou.
Asian Pac J Cancer Prev, 2020 Sep 29; 21(9). PMID: 32986353    Free PMC article.
Factors That Predict Biological Aggressiveness in Estrogen Receptor-Positive / Human Epidermal Growth Factor Receptor 2-Negative / Lymph Node-Negative Breast Cancer.
Lauren E Arthur, Ashley H McMann, +4 authors, Ralph L Corsetti.
Ochsner J, 2021 Jan 08; 20(4). PMID: 33408575    Free PMC article.
Chip-Scale Angle-Selective Imager for In Vivo Microscopic Cancer Detection.
Efthymios P Papageorgiou, Bernhard E Boser, Mekhail Anwar.
IEEE Trans Biomed Circuits Syst, 2019 Dec 14; 14(1). PMID: 31831434    Free PMC article.
A Novel Staging System for De Novo Metastatic Breast Cancer Refines Prognostic Estimates.
Jennifer K Plichta, Samantha M Thomas, +7 authors, E Shelley Hwang.
Ann Surg, 2020 Jul 14;. PMID: 32657941    Free PMC article.
Prognostic and predictive parameters in breast pathology: a pathologist's primer.
Kimberly H Allison.
Mod Pathol, 2020 Nov 07; 34(Suppl 1). PMID: 33154551
SOX12 expression is associated with progression and poor prognosis in human breast cancer.
Junming Xu, Jinyan Zhang, +3 authors, Yang Li.
Am J Transl Res, 2021 Jan 14; 12(12). PMID: 33437389    Free PMC article.
Staging for Breast Cancer With Internal Mammary Lymph Nodes Metastasis: Utility of Incorporating Biologic Factors.
Chen-Lu Lian, Hai-Yan Zhang, +4 authors, San-Gang Wu.
Front Oncol, 2021 Feb 02; 10. PMID: 33520700    Free PMC article.
Combined analysis of miR-200 family and its significance for breast cancer.
Andrea Fontana, Raffaela Barbano, +16 authors, Paola Parrella.
Sci Rep, 2021 Feb 05; 11(1). PMID: 33536459    Free PMC article.
Concordance between results of inexpensive statistical models and multigene signatures in patients with ER+/HER2- early breast cancer.
Laurence Slembrouck, Isabelle Vanden Bempt, +12 authors, Giuseppe Floris.
Mod Pathol, 2021 Feb 10;. PMID: 33558657
Targeting the purinergic pathway in breast cancer and its therapeutic applications.
Julia Beatrice de Araújo, Vanessa Vitória Kerkhoff, Sarah Franco Vieira de Oliveira Maciel, Débora Tavares de Resende E Silva.
Purinergic Signal, 2021 Feb 13;. PMID: 33576905    Free PMC article.
Review.