. 2017 Mar; 15(6):635-650.
doi: 10.1158/1541-7786.MCR-16-0427.

Cancer Immunotherapy: Whence and Whither

Peter J Stambrook 1 John Maher 2 Farzin Farzaneh 3 
  • PMID: 28356330
  •     213 References
  •     19 citations


The current concepts and practice of cancer immunotherapy evolved from classical experiments that distinguished "self" from "non-self" and the finding that humoral immunity is complemented by cellular immunity. Elucidation of the biology underlying immune checkpoints and interactions between ligands and ligand receptors that govern the immune system's ability to recognize tumor cells as foreign has led to the emergence of new strategies that mobilize the immune system to reverse this apparent tolerance. Some of these approaches have led to new therapies such as the use of mAbs to interfere with the immune checkpoint. Others have exploited molecular technologies to reengineer a subset of T cells to directly engage and kill tumor cells, particularly those of B-cell malignancies. However, before immunotherapy can become a more effective method of cancer care, there are many challenges that remain to be addressed and hurdles to overcome. Included are manipulation of tumor microenvironment (TME) to enhance T effector cell infiltration and access to the tumor, augmentation of tumor MHC expression for adequate presentation of tumor associated antigens, regulation of cytokines and their potential adverse effects, and reduced risk of secondary malignancies as a consequence of mutations generated by the various forms of genetic engineering of immune cells. Despite these challenges, the future of immunotherapy as a standard anticancer therapy is encouraging. Mol Cancer Res; 15(6); 635-50. ©2017 AACR.

Costimulation of antitumor immunity by the B7 counterreceptor for the T lymphocyte molecules CD28 and CTLA-4.
L Chen, S Ashe, +5 authors, P S Linsley.
Cell, 1992 Dec 24; 71(7). PMID: 1335364
Highly Cited.
Convergence of Acquired Mutations and Alternative Splicing of CD19 Enables Resistance to CART-19 Immunotherapy.
Elena Sotillo, David M Barrett, +27 authors, Andrei Thomas-Tikhonenko.
Cancer Discov, 2015 Nov 01; 5(12). PMID: 26516065    Free PMC article.
Highly Cited.
IL-2: the first effective immunotherapy for human cancer.
Steven A Rosenberg.
J Immunol, 2014 Jun 08; 192(12). PMID: 24907378    Free PMC article.
Highly Cited. Review.
c-myc down-regulates class I HLA expression in human melanomas.
R Versteeg, I A Noordermeer, +2 authors, P I Schrier.
EMBO J, 1988 Apr 01; 7(4). PMID: 3402430    Free PMC article.
PD-L1 and Tumor Infiltrating Lymphocytes as Prognostic Markers in Resected NSCLC.
Malaka Ameratunga, Khashayar Asadi, +6 authors, Thomas John.
PLoS One, 2016 Apr 23; 11(4). PMID: 27104612    Free PMC article.
Dual CD19 and CD123 targeting prevents antigen-loss relapses after CD19-directed immunotherapies.
Marco Ruella, David M Barrett, +18 authors, Saar Gill.
J Clin Invest, 2016 Aug 30; 126(10). PMID: 27571406    Free PMC article.
Highly Cited.
Current concepts in the diagnosis and management of cytokine release syndrome.
Daniel W Lee, Rebecca Gardner, +5 authors, Crystal L Mackall.
Blood, 2014 May 31; 124(2). PMID: 24876563    Free PMC article.
Highly Cited.
Myeloid-derived suppressor cells in the tumor microenvironment: expect the unexpected.
Douglas Marvel, Dmitry I Gabrilovich.
J Clin Invest, 2015 Jul 15; 125(9). PMID: 26168215    Free PMC article.
Highly Cited. Review.
Inhibitory Fc receptors modulate in vivo cytotoxicity against tumor targets.
R A Clynes, T L Towers, L G Presta, J V Ravetch.
Nat Med, 2000 Mar 31; 6(4). PMID: 10742152
Highly Cited.
Decade-long safety and function of retroviral-modified chimeric antigen receptor T cells.
John Scholler, Troy L Brady, +13 authors, Carl H June.
Sci Transl Med, 2012 May 04; 4(132). PMID: 22553251    Free PMC article.
Highly Cited.
Efficacy and toxicity management of 19-28z CAR T cell therapy in B cell acute lymphoblastic leukemia.
Marco L Davila, Isabelle Riviere, +29 authors, Renier Brentjens.
Sci Transl Med, 2014 Feb 21; 6(224). PMID: 24553386    Free PMC article.
Highly Cited.
Cytotoxic T lymphocyte granules are secretory lysosomes, containing both perforin and granzymes.
P J Peters, J Borst, +5 authors, H J Geuze.
J Exp Med, 1991 May 01; 173(5). PMID: 2022921    Free PMC article.
Highly Cited.
PD-L1 expression in melanoma shows marked heterogeneity within and between patients: implications for anti-PD-1/PD-L1 clinical trials.
Jason Madore, Ricardo E Vilain, +9 authors, Richard A Scolyer.
Pigment Cell Melanoma Res, 2014 Dec 06; 28(3). PMID: 25477049
Highly Cited.
Use of tumor-infiltrating lymphocytes and interleukin-2 in the immunotherapy of patients with metastatic melanoma. A preliminary report.
S A Rosenberg, B S Packard, +7 authors, C A Seipp.
N Engl J Med, 1988 Dec 22; 319(25). PMID: 3264384
Highly Cited.
Cancer immunology. Mutational landscape determines sensitivity to PD-1 blockade in non-small cell lung cancer.
Naiyer A Rizvi, Matthew D Hellmann, +21 authors, Timothy A Chan.
Science, 2015 Mar 15; 348(6230). PMID: 25765070    Free PMC article.
Highly Cited.
Genomic correlates of response to CTLA-4 blockade in metastatic melanoma.
Eliezer M Van Allen, Diana Miao, +19 authors, Levi A Garraway.
Science, 2015 Sep 12; 350(6257). PMID: 26359337    Free PMC article.
Highly Cited.
Fas(CD95)/FasL interactions required for programmed cell death after T-cell activation.
S T Ju, D J Panka, +5 authors, A Marshak-Rothstein.
Nature, 1995 Feb 02; 373(6513). PMID: 7530337
Highly Cited.
Local versus systemic interleukin-2: tumor formation by wild-type and B7-1-positive murine melanoma cells.
A L Barnard, F Farzaneh, J Gäken, D Darling.
Cancer Gene Ther, 2000 Apr 19; 7(2). PMID: 10770628
Adenosine A2A receptors intrinsically regulate CD8+ T cells in the tumor microenvironment.
Caglar Cekic, Joel Linden.
Cancer Res, 2014 Oct 25; 74(24). PMID: 25341542    Free PMC article.
Adenosine generation catalyzed by CD39 and CD73 expressed on regulatory T cells mediates immune suppression.
Silvia Deaglio, Karen M Dwyer, +10 authors, Simon C Robson.
J Exp Med, 2007 May 16; 204(6). PMID: 17502665    Free PMC article.
Highly Cited.
Chimeric antigen receptor-modified T cells in chronic lymphoid leukemia.
David L Porter, Bruce L Levine, +2 authors, Carl H June.
N Engl J Med, 2011 Aug 13; 365(8). PMID: 21830940    Free PMC article.
Highly Cited.
Tandem CAR T cells targeting HER2 and IL13Rα2 mitigate tumor antigen escape.
Meenakshi Hegde, Malini Mukherjee, +18 authors, Nabil Ahmed.
J Clin Invest, 2016 Jul 19; 126(8). PMID: 27427982    Free PMC article.
Highly Cited.
IL-12 produced by dendritic cells augments CD8+ T cell activation through the production of the chemokines CCL1 and CCL17.
Curtis J Henry, David A Ornelles, +2 authors, Elizabeth M Hiltbold.
J Immunol, 2008 Dec 04; 181(12). PMID: 19050277    Free PMC article.
Tumor-induced myeloid deviation: when myeloid-derived suppressor cells meet tumor-associated macrophages.
Stefano Ugel, Francesco De Sanctis, Susanna Mandruzzato, Vincenzo Bronte.
J Clin Invest, 2015 Sep 02; 125(9). PMID: 26325033    Free PMC article.
Highly Cited. Review.
CD73: a novel target for cancer immunotherapy.
Bin Zhang.
Cancer Res, 2010 Aug 05; 70(16). PMID: 20682793    Free PMC article.
Suppression of antitumor immunity by IL-10 and TGF-beta-producing T cells infiltrating the growing tumor: influence of tumor environment on the induction of CD4+ and CD8+ regulatory T cells.
Andrew G Jarnicki, Joanne Lysaght, Stephen Todryk, Kingston H G Mills.
J Immunol, 2006 Jul 05; 177(2). PMID: 16818744
Embryonic stem cells and somatic cells differ in mutation frequency and type.
Rachel B Cervantes, James R Stringer, +2 authors, Peter J Stambrook.
Proc Natl Acad Sci U S A, 2002 Mar 14; 99(6). PMID: 11891338    Free PMC article.
Low surface expression of B7-1 (CD80) is an immunoescape mechanism of colon carcinoma.
Iñigo Tirapu, Eduardo Huarte, +11 authors, Ignacio Melero.
Cancer Res, 2006 Feb 21; 66(4). PMID: 16489051
BRAFV600E Co-opts a Conserved MHC Class I Internalization Pathway to Diminish Antigen Presentation and CD8+ T-cell Recognition of Melanoma.
Sherille D Bradley, Zeming Chen, +12 authors, Gregory Lizée.
Cancer Immunol Res, 2015 Mar 22; 3(6). PMID: 25795007    Free PMC article.
T-lymphocyte recognition of antigen in association with gene products of the major histocompatibility complex.
R H Schwartz.
Annu Rev Immunol, 1985 Jan 01; 3. PMID: 2415139
Highly Cited. Review.
Small interfering RNA (siRNA) inhibits the expression of the Her2/neu gene, upregulates HLA class I and induces apoptosis of Her2/neu positive tumor cell lines.
Aniruddha Choudhury, Jehad Charo, +4 authors, Rolf Kiessling.
Int J Cancer, 2003 Nov 18; 108(1). PMID: 14618618
Chimeric antigen receptor T cells for sustained remissions in leukemia.
Shannon L Maude, Noelle Frey, +16 authors, Stephan A Grupp.
N Engl J Med, 2014 Oct 16; 371(16). PMID: 25317870    Free PMC article.
Highly Cited.
The functional network of ion channels in T lymphocytes.
Michael D Cahalan, K George Chandy.
Immunol Rev, 2009 Sep 17; 231(1). PMID: 19754890    Free PMC article.
Highly Cited. Review.
STIM1 and STIM2-mediated Ca(2+) influx regulates antitumour immunity by CD8(+) T cells.
Carl Weidinger, Patrick J Shaw, Stefan Feske.
EMBO Mol Med, 2013 Aug 08; 5(9). PMID: 23922331    Free PMC article.
Observations on the systemic administration of autologous lymphokine-activated killer cells and recombinant interleukin-2 to patients with metastatic cancer.
S A Rosenberg, M T Lotze, +7 authors, J T Vetto.
N Engl J Med, 1985 Dec 05; 313(23). PMID: 3903508
Highly Cited.
Bispecific T-cell engagers for cancer immunotherapy.
Amelia M Huehls, Tiffany A Coupet, Charles L Sentman.
Immunol Cell Biol, 2014 Nov 05; 93(3). PMID: 25367186    Free PMC article.
Highly Cited. Review.
Managing cytokine release syndrome associated with novel T cell-engaging therapies.
Shannon L Maude, David Barrett, David T Teachey, Stephan A Grupp.
Cancer J, 2014 Mar 29; 20(2). PMID: 24667956    Free PMC article.
Highly Cited. Review.
T cells with chimeric antigen receptors have potent antitumor effects and can establish memory in patients with advanced leukemia.
Michael Kalos, Bruce L Levine, +4 authors, Carl H June.
Sci Transl Med, 2011 Aug 13; 3(95). PMID: 21832238    Free PMC article.
Highly Cited.
TRUCKs: the fourth generation of CARs.
Markus Chmielewski, Hinrich Abken.
Expert Opin Biol Ther, 2015 May 20; 15(8). PMID: 25985798
Highly Cited. Review.
Therapeutic Potential of T Cell Chimeric Antigen Receptors (CARs) in Cancer Treatment: Counteracting Off-Tumor Toxicities for Safe CAR T Cell Therapy.
Gideon Gross, Zelig Eshhar.
Annu Rev Pharmacol Toxicol, 2016 Jan 08; 56. PMID: 26738472
Highly Cited. Review.
Critical Role for CD103(+)/CD141(+) Dendritic Cells Bearing CCR7 for Tumor Antigen Trafficking and Priming of T Cell Immunity in Melanoma.
Edward W Roberts, Miranda L Broz, +7 authors, Matthew F Krummel.
Cancer Cell, 2016 Jul 19; 30(2). PMID: 27424807    Free PMC article.
Highly Cited.
Lentiviral vector common integration sites in preclinical models and a clinical trial reflect a benign integration bias and not oncogenic selection.
Alessandra Biffi, Cynthia C Bartolomae, +15 authors, Eugenio Montini.
Blood, 2011 Mar 16; 117(20). PMID: 21403130
Highly Cited.
Diabetes mellitus and increased risk of cancer: focus on metformin and the insulin analogs.
M Shawn McFarland, Rebecca Cripps.
Pharmacotherapy, 2010 Oct 27; 30(11). PMID: 20973689
Treatment of metastatic renal cell carcinoma (mRCC) with CAIX CAR-engineered T-cells-a completed study overview.
Cor H J Lamers, Yarne Klaver, +2 authors, Reno Debets.
Biochem Soc Trans, 2016 Jun 11; 44(3). PMID: 27284065
Organization of proximal signal initiation at the TCR:CD3 complex.
Clifford S Guy, Dario A A Vignali.
Immunol Rev, 2009 Nov 17; 232(1). PMID: 19909352    Free PMC article.
Targeting fibroblast activation protein in tumor stroma with chimeric antigen receptor T cells can inhibit tumor growth and augment host immunity without severe toxicity.
Liang-Chuan S Wang, Albert Lo, +11 authors, Steven M Albelda.
Cancer Immunol Res, 2014 Apr 30; 2(2). PMID: 24778279    Free PMC article.
Highly Cited.
Culture of human mesenchymal stem cells at low oxygen tension improves growth and genetic stability by activating glycolysis.
J C Estrada, C Albo, +8 authors, E Samper.
Cell Death Differ, 2011 Dec 06; 19(5). PMID: 22139129    Free PMC article.
Events that led to the discovery of T-cell development and function--a personal recollection.
J F A P Miller.
Tissue Antigens, 2004 May 14; 63(6). PMID: 15140026
Expression of immunoglobulin-T-cell receptor chimeric molecules as functional receptors with antibody-type specificity.
G Gross, T Waks, Z Eshhar.
Proc Natl Acad Sci U S A, 1989 Dec 01; 86(24). PMID: 2513569    Free PMC article.
Highly Cited.
Human T-lymphocyte cytotoxicity and proliferation directed by a single chimeric TCRzeta /CD28 receptor.
John Maher, Renier J Brentjens, +2 authors, Michel Sadelain.
Nat Biotechnol, 2001 Dec 26; 20(1). PMID: 11753365
Highly Cited.
Adoptive cell transfer: a clinical path to effective cancer immunotherapy.
Steven A Rosenberg, Nicholas P Restifo, +2 authors, Mark E Dudley.
Nat Rev Cancer, 2008 Mar 21; 8(4). PMID: 18354418    Free PMC article.
Highly Cited. Review.
Preclinical targeting of human acute myeloid leukemia and myeloablation using chimeric antigen receptor-modified T cells.
Saar Gill, Sarah K Tasian, +9 authors, Michael Kalos.
Blood, 2014 Mar 07; 123(15). PMID: 24596416    Free PMC article.
Highly Cited.
CD19-targeted T cells rapidly induce molecular remissions in adults with chemotherapy-refractory acute lymphoblastic leukemia.
Renier J Brentjens, Marco L Davila, +22 authors, Michel Sadelain.
Sci Transl Med, 2013 Mar 22; 5(177). PMID: 23515080    Free PMC article.
Highly Cited.
Plaque formation in agar by single antibody-producing cells.
Science, 1963 Apr 26; 140(3565). PMID: 13957684
Highly Cited.
Ca2+ regulates T-cell receptor activation by modulating the charge property of lipids.
Xiaoshan Shi, Yunchen Bi, +13 authors, Chenqi Xu.
Nature, 2012 Dec 04; 493(7430). PMID: 23201688
Suppression of MHC class I gene expression by N-myc through enhancer inactivation.
M Lenardo, A K Rustgi, A R Schievella, R Bernards.
EMBO J, 1989 Nov 01; 8(11). PMID: 2583102    Free PMC article.
Engineering Customized Cell Sensing and Response Behaviors Using Synthetic Notch Receptors.
Leonardo Morsut, Kole T Roybal, +4 authors, Wendell A Lim.
Cell, 2016 Feb 03; 164(4). PMID: 26830878    Free PMC article.
Highly Cited.
Cell to cell interaction in the immune response. II. The source of hemolysin-forming cells in irradiated mice given bone marrow and thymus or thoracic duct lymphocytes.
G F Mitchell, J F Miller.
J Exp Med, 1968 Oct 01; 128(4). PMID: 5691986    Free PMC article.
Highly Cited.
Anti-CD73 antibody therapy inhibits breast tumor growth and metastasis.
John Stagg, Upulie Divisekera, +5 authors, Mark J Smyth.
Proc Natl Acad Sci U S A, 2010 Jan 19; 107(4). PMID: 20080644    Free PMC article.
Highly Cited.
Induced expression of PD-1, a novel member of the immunoglobulin gene superfamily, upon programmed cell death.
Y Ishida, Y Agata, K Shibahara, T Honjo.
EMBO J, 1992 Nov 01; 11(11). PMID: 1396582    Free PMC article.
Highly Cited.
Engagement of the PD-1 immunoinhibitory receptor by a novel B7 family member leads to negative regulation of lymphocyte activation.
G J Freeman, A J Long, +16 authors, T Honjo.
J Exp Med, 2000 Oct 04; 192(7). PMID: 11015443    Free PMC article.
Highly Cited.
Cholesterol and sphingomyelin drive ligand-independent T-cell antigen receptor nanoclustering.
Eszter Molnár, Mahima Swamy, +9 authors, Wolfgang W A Schamel.
J Biol Chem, 2012 Oct 24; 287(51). PMID: 23091059    Free PMC article.
Adjuvant ipilimumab versus placebo after complete resection of high-risk stage III melanoma (EORTC 18071): a randomised, double-blind, phase 3 trial.
Alexander M M Eggermont, Vanna Chiarion-Sileni, +19 authors, Alessandro Testori.
Lancet Oncol, 2015 Apr 05; 16(5). PMID: 25840693
Highly Cited.
Signals through T cell receptor-zeta chain alone are insufficient to prime resting T lymphocytes.
T Brocker, K Karjalainen.
J Exp Med, 1995 May 01; 181(5). PMID: 7722445    Free PMC article.
CAR T-cell immunotherapy: The path from the by-road to the freeway?
Lynsey M Whilding, John Maher.
Mol Oncol, 2015 Nov 14; 9(10). PMID: 26563646    Free PMC article.
Development of lupus-like autoimmune diseases by disruption of the PD-1 gene encoding an ITIM motif-carrying immunoreceptor.
H Nishimura, M Nose, +2 authors, T Honjo.
Immunity, 1999 Sep 15; 11(2). PMID: 10485649
Highly Cited.
From humble beginnings to success in the clinic: Chimeric antigen receptor-modified T-cells and implications for immunotherapy.
Amelia E Firor, Alexander Jares, Yupo Ma.
Exp Biol Med (Maywood), 2015 May 10; 240(8). PMID: 25956686    Free PMC article.
Combined IL-21-primed polyclonal CTL plus CTLA4 blockade controls refractory metastatic melanoma in a patient.
Aude G Chapuis, Sylvia M Lee, +11 authors, Cassian Yee.
J Exp Med, 2016 Jun 01; 213(7). PMID: 27242164    Free PMC article.
Role of A2a extracellular adenosine receptor-mediated signaling in adenosine-mediated inhibition of T-cell activation and expansion.
S Huang, S Apasov, M Koshiba, M Sitkovsky.
Blood, 1997 Aug 15; 90(4). PMID: 9269779
Highly Cited.
Case report of a serious adverse event following the administration of T cells transduced with a chimeric antigen receptor recognizing ERBB2.
Richard A Morgan, James C Yang, +3 authors, Steven A Rosenberg.
Mol Ther, 2010 Feb 25; 18(4). PMID: 20179677    Free PMC article.
Highly Cited.
Sterol regulatory element-binding proteins are essential for the metabolic programming of effector T cells and adaptive immunity.
Yoko Kidani, Heidi Elsaesser, +11 authors, Steven J Bensinger.
Nat Immunol, 2013 Apr 09; 14(5). PMID: 23563690    Free PMC article.
Highly Cited.
Passive transfer of transplantation immunity.
Nature, 1953 Feb 07; 171(4345). PMID: 13036857
Highly Cited.
Oxygen accelerates the accumulation of mutations during the senescence and immortalization of murine cells in culture.
Rita A Busuttil, Miguel Rubio, +2 authors, Jan Vijg.
Aging Cell, 2003 Dec 18; 2(6). PMID: 14677631
A new approach to the adoptive immunotherapy of cancer with tumor-infiltrating lymphocytes.
S A Rosenberg, P Spiess, R Lafreniere.
Science, 1986 Sep 19; 233(4770). PMID: 3489291
Highly Cited.
Multiplex Genome-Edited T-cell Manufacturing Platform for "Off-the-Shelf" Adoptive T-cell Immunotherapies.
Laurent Poirot, Brian Philip, +17 authors, Julianne Smith.
Cancer Res, 2015 Jul 18; 75(18). PMID: 26183927
Highly Cited.
Actively acquired tolerance of foreign cells.
Nature, 1953 Oct 03; 172(4379). PMID: 13099277
Highly Cited.
N-myc suppresses major histocompatibility complex class I gene expression through down-regulation of the p50 subunit of NF-kappa B.
L J van 't Veer, R L Beijersbergen, R Bernards.
EMBO J, 1993 Jan 01; 12(1). PMID: 8428579    Free PMC article.
Recent advances in the use of metformin: can treating diabetes prevent breast cancer?
Diana Hatoum, Eileen M McGowan.
Biomed Res Int, 2015 Apr 14; 2015. PMID: 25866793    Free PMC article.
Tumor rejection after direct costimulation of CD8+ T cells by B7-transfected melanoma cells.
S E Townsend, J P Allison.
Science, 1993 Jan 15; 259(5093). PMID: 7678351
Highly Cited.
Ion channels in innate and adaptive immunity.
Stefan Feske, Heike Wulff, Edward Y Skolnik.
Annu Rev Immunol, 2015 Apr 12; 33. PMID: 25861976    Free PMC article.
Highly Cited. Review.
The B7-CD28 superfamily.
Arlene H Sharpe, Gordon J Freeman.
Nat Rev Immunol, 2002 Mar 26; 2(2). PMID: 11910893
Highly Cited. Review.
Antibody-modified T cells: CARs take the front seat for hematologic malignancies.
Marcela V Maus, Stephan A Grupp, David L Porter, Carl H June.
Blood, 2014 Mar 01; 123(17). PMID: 24578504    Free PMC article.
Highly Cited. Review.
Metformin and reduced risk of cancer in diabetic patients.
Josie M M Evans, Louise A Donnelly, +2 authors, Andrew D Morris.
BMJ, 2005 Apr 26; 330(7503). PMID: 15849206    Free PMC article.
Highly Cited.
Immunological surveillance against altered self components by sensitised T lymphocytes in lymphocytic choriomeningitis.
R M Zinkernagel, P C Doherty.
Nature, 1974 Oct 11; 251(5475). PMID: 4547543
Highly Cited.
Metformin rescues cell surface major histocompatibility complex class I (MHC-I) deficiency caused by oncogenic transformation.
Cristina Oliveras-Ferraros, Sílvia Cufí, +5 authors, Javier A Menendez.
Cell Cycle, 2012 Feb 16; 11(5). PMID: 22333588
Restriction of in vitro T cell-mediated cytotoxicity in lymphocytic choriomeningitis within a syngeneic or semiallogeneic system.
R M Zinkernagel, P C Doherty.
Nature, 1974 Apr 19; 248(5450). PMID: 4133807
Highly Cited.
MYC regulates the antitumor immune response through CD47 and PD-L1.
Stephanie C Casey, Ling Tong, +8 authors, Dean W Felsher.
Science, 2016 Mar 12; 352(6282). PMID: 26966191    Free PMC article.
Highly Cited.
IgG2a monoclonal antibodies inhibit human tumor growth through interaction with effector cells.
D Herlyn, H Koprowski.
Proc Natl Acad Sci U S A, 1982 Aug 01; 79(15). PMID: 6289317    Free PMC article.
Highly Cited.
DNA repair and nonmelanoma skin cancer in Puerto Rican populations.
Jaime L Matta, Jaime L Villa, +4 authors, Lawrence Grossman.
J Am Acad Dermatol, 2003 Sep 10; 49(3). PMID: 12963906
Immune related adverse events associated with anti-CTLA-4 antibodies: systematic review and meta-analysis.
Anne Bertrand, Marie Kostine, +2 authors, Thierry Schaeverbeke.
BMC Med, 2015 Sep 05; 13. PMID: 26337719    Free PMC article.
Highly Cited. Systematic Review.
Long-term metformin use is associated with decreased risk of breast cancer.
Michael Bodmer, Christian Meier, +2 authors, Christoph R Meier.
Diabetes Care, 2010 Mar 20; 33(6). PMID: 20299480    Free PMC article.
Highly Cited.
Precision Tumor Recognition by T Cells With Combinatorial Antigen-Sensing Circuits.
Kole T Roybal, Levi J Rupp, +4 authors, Wendell A Lim.
Cell, 2016 Feb 03; 164(4). PMID: 26830879    Free PMC article.
Highly Cited.
Irradiated NC adenocarcinoma cells transduced with both B7.1 and interleukin-2 induce CD4+-mediated rejection of established tumors.
J A Gaken, S J Hollingsworth, +11 authors, D C Darling.
Hum Gene Ther, 1997 Mar 01; 8(4). PMID: 9054522
Current state of anti-PD-L1 and anti-PD-1 agents in cancer therapy.
Abhisek Swaika, William A Hammond, Richard W Joseph.
Mol Immunol, 2015 Mar 10; 67(2 Pt A). PMID: 25749122
Highly Cited. Review.
Toxicity and management in CAR T-cell therapy.
Challice L Bonifant, Hollie J Jackson, Renier J Brentjens, Kevin J Curran.
Mol Ther Oncolytics, 2016 Sep 15; 3. PMID: 27626062    Free PMC article.
Highly Cited. Review.
Chimeric Fv-zeta or Fv-epsilon receptors are not sufficient to induce activation or cytokine production in peripheral T cells.
T Brocker.
Blood, 2000 Aug 29; 96(5). PMID: 10961908
Adenosine as a possible inhibitor of killer T-cell activation in the microenvironment of solid tumours.
D W Hoskin, T Reynolds, J Blay.
Int J Cancer, 1994 Dec 15; 59(6). PMID: 7989130
Tumor-targeted T cells modified to secrete IL-12 eradicate systemic tumors without need for prior conditioning.
Hollie J Pegram, James C Lee, +4 authors, Renier J Brentjens.
Blood, 2012 Feb 23; 119(18). PMID: 22354001    Free PMC article.
Highly Cited.
High frequency in vivo loss of heterozygosity is primarily a consequence of mitotic recombination.
P K Gupta, A Sahota, +7 authors, J A Tischfield.
Cancer Res, 1997 Mar 15; 57(6). PMID: 9067291
Dissecting the tumor myeloid compartment reveals rare activating antigen-presenting cells critical for T cell immunity.
Miranda L Broz, Mikhail Binnewies, +12 authors, Matthew F Krummel.
Cancer Cell, 2014 Dec 03; 26(5). PMID: 25446897    Free PMC article.
Highly Cited.
Cytokine secretion is distinct from secretion of cytotoxic granules in NK cells.
Esther Reefman, Jason G Kay, +7 authors, Jennifer L Stow.
J Immunol, 2010 Apr 07; 184(9). PMID: 20368273
Chemotherapy-refractory diffuse large B-cell lymphoma and indolent B-cell malignancies can be effectively treated with autologous T cells expressing an anti-CD19 chimeric antigen receptor.
James N Kochenderfer, Mark E Dudley, +23 authors, Steven A Rosenberg.
J Clin Oncol, 2014 Aug 27; 33(6). PMID: 25154820    Free PMC article.
Highly Cited.
Chimeric receptors with 4-1BB signaling capacity provoke potent cytotoxicity against acute lymphoblastic leukemia.
C Imai, K Mihara, +4 authors, D Campana.
Leukemia, 2004 Feb 13; 18(4). PMID: 14961035
Highly Cited.
Depletion of FAP+ cells reduces immunosuppressive cells and improves metabolism and functions CD8+T cells within tumors.
Ying Zhang, Hildegund C J Ertl.
Oncotarget, 2016 Mar 05; 7(17). PMID: 26943036    Free PMC article.
Mutator phenotype may be required for multistage carcinogenesis.
L A Loeb.
Cancer Res, 1991 Jun 15; 51(12). PMID: 2039987
Highly Cited. Review.
Suppression of MHC class I antigens in oncogenic transformants: association with decreased recognition by cytotoxic T lymphocytes.
B Seliger, C Harders, +3 authors, C Huber.
Exp Hematol, 1996 Sep 01; 24(11). PMID: 8862437
Inactivation of PI(3)K p110δ breaks regulatory T-cell-mediated immune tolerance to cancer.
Khaled Ali, Dalya R Soond, +11 authors, Bart Vanhaesebroeck.
Nature, 2014 Jun 12; 510(7505). PMID: 24919154    Free PMC article.
Highly Cited.
Human CD80/IL2 lentivirus-transduced acute myeloid leukaemia (AML) cells promote natural killer (NK) cell activation and cytolytic activity: implications for a phase I clinical study.
Wendy Ingram, Lucas Chan, +6 authors, Farzin Farzaneh.
Br J Haematol, 2009 Apr 25; 145(6). PMID: 19388935
Adenine phosphoribosyltransferase-deficient mice develop 2,8-dihydroxyadenine nephrolithiasis.
S J Engle, M G Stockelman, +8 authors, J A Tischfield.
Proc Natl Acad Sci U S A, 1996 May 28; 93(11). PMID: 8643571    Free PMC article.
Combinatorial antigen recognition with balanced signaling promotes selective tumor eradication by engineered T cells.
Christopher C Kloss, Maud Condomines, +2 authors, Michel Sadelain.
Nat Biotechnol, 2012 Dec 18; 31(1). PMID: 23242161    Free PMC article.
Highly Cited.
Identification of Predictive Biomarkers for Cytokine Release Syndrome after Chimeric Antigen Receptor T-cell Therapy for Acute Lymphoblastic Leukemia.
David T Teachey, Simon F Lacey, +23 authors, Stephan A Grupp.
Cancer Discov, 2016 Apr 15; 6(6). PMID: 27076371    Free PMC article.
Highly Cited.
The low-density lipoprotein pathway and its relation to atherosclerosis.
J L Goldstein, M S Brown.
Annu Rev Biochem, 1977 Jan 01; 46. PMID: 197883
Highly Cited. Review.
B7-H1 expression on non-small cell lung cancer cells and its relationship with tumor-infiltrating lymphocytes and their PD-1 expression.
Jun Konishi, Koichi Yamazaki, +3 authors, Masaharu Nishimura.
Clin Cancer Res, 2004 Aug 07; 10(15). PMID: 15297412
Highly Cited.
The pharmacology of second-generation chimeric antigen receptors.
Sjoukje J C van der Stegen, Mohamad Hamieh, Michel Sadelain.
Nat Rev Drug Discov, 2015 Jul 02; 14(7). PMID: 26129802    Free PMC article.
Highly Cited. Review.
New users of metformin are at low risk of incident cancer: a cohort study among people with type 2 diabetes.
Gillian Libby, Louise A Donnelly, +3 authors, Josie M M Evans.
Diabetes Care, 2009 Jul 01; 32(9). PMID: 19564453    Free PMC article.
Highly Cited.
Science, 1965 Feb 19; 147(3660). PMID: 14245768
Highly Cited.
Somatic mutations and aging: a re-evaluation.
J Vijg.
Mutat Res, 2000 Feb 25; 447(1). PMID: 10686308
Treatment of metastatic melanoma using interleukin-2 alone or in conjunction with vaccines.
Franz O Smith, Stephanie G Downey, +10 authors, Steven A Rosenberg.
Clin Cancer Res, 2008 Sep 04; 14(17). PMID: 18765555    Free PMC article.
Local changes in lipid environment of TCR microclusters regulate membrane binding by the CD3ε cytoplasmic domain.
Etienne Gagnon, David A Schubert, +2 authors, Kai W Wucherpfennig.
J Exp Med, 2012 Nov 21; 209(13). PMID: 23166358    Free PMC article.
Chimeric antigen receptors against CD33/CD123 antigens efficiently target primary acute myeloid leukemia cells in vivo.
I Pizzitola, F Anjos-Afonso, +6 authors, D Bonnet.
Leukemia, 2014 Feb 08; 28(8). PMID: 24504024
Highly Cited.
Novel immunotherapies in lymphoid malignancies.
Connie Lee Batlevi, Eri Matsuki, Renier J Brentjens, Anas Younes.
Nat Rev Clin Oncol, 2015 Nov 04; 13(1). PMID: 26525683    Free PMC article.
Highly Cited. Review.
A2A adenosine receptor protects tumors from antitumor T cells.
Akio Ohta, Elieser Gorelik, +12 authors, Michail Sitkovsky.
Proc Natl Acad Sci U S A, 2006 Aug 19; 103(35). PMID: 16916931    Free PMC article.
Highly Cited.
N-myc amplification causes down-modulation of MHC class I antigen expression in neuroblastoma.
R Bernards, S K Dessain, R A Weinberg.
Cell, 1986 Dec 05; 47(5). PMID: 3096575
High-dose interleukin-2 for the treatment of metastatic renal cell carcinoma : a retrospective analysis of response and survival in patients treated in the surgery branch at the National Cancer Institute between 1986 and 2006.
Jacob A Klapper, Stephanie G Downey, +7 authors, Steven Rosenberg.
Cancer, 2008 May 07; 113(2). PMID: 18457330    Free PMC article.
Highly Cited.
In vivo loss of heterozygosity in T-cells of B6C3F1 Aprt(+/-) mice.
L Liang, L Deng, +2 authors, J A Tischfield.
Environ Mol Mutagen, 2000 Mar 11; 35(2). PMID: 10712749
Preclinical in vivo modeling of cytokine release syndrome induced by ErbB-retargeted human T cells: identifying a window of therapeutic opportunity?
Sjoukje J C van der Stegen, David M Davies, +10 authors, John Maher.
J Immunol, 2013 Sep 26; 191(9). PMID: 24062490
Enhancement of tumor immunotherapy by deletion of the A2A adenosine receptor.
Adam T Waickman, Angela Alme, +3 authors, Jonathan D Powell.
Cancer Immunol Immunother, 2011 Nov 26; 61(6). PMID: 22116345    Free PMC article.
Suppression of antitumor immunity by stromal cells expressing fibroblast activation protein-alpha.
Matthew Kraman, Paul J Bambrough, +6 authors, Douglas T Fearon.
Science, 2010 Nov 06; 330(6005). PMID: 21051638
Highly Cited.
Monoclonal antibodies: versatile platforms for cancer immunotherapy.
Louis M Weiner, Rishi Surana, Shangzi Wang.
Nat Rev Immunol, 2010 Apr 24; 10(5). PMID: 20414205    Free PMC article.
Highly Cited. Review.
Effect of dietary restriction on in vivo somatic mutation in mice.
J L Dempsey, M Pfeiffer, A A Morley.
Mutat Res, 1993 Apr 01; 291(2). PMID: 7680418
Ex vivo expansion of human T cells for adoptive immunotherapy using the novel Xeno-free CTS Immune Cell Serum Replacement.
Corey Smith, Grethe Økern, +5 authors, Rajiv Khanna.
Clin Transl Immunology, 2015 Feb 12; 4(1). PMID: 25671129    Free PMC article.
Safety and clinical activity of pembrolizumab for treatment of recurrent or metastatic squamous cell carcinoma of the head and neck (KEYNOTE-012): an open-label, multicentre, phase 1b trial.
Tanguy Y Seiwert, Barbara Burtness, +9 authors, Laura Q Chow.
Lancet Oncol, 2016 Jun 02; 17(7). PMID: 27247226
Highly Cited.
CTLA-4 blockade with ipilimumab: long-term follow-up of 177 patients with metastatic melanoma.
Peter A Prieto, James C Yang, +6 authors, Giao Q Phan.
Clin Cancer Res, 2012 Jan 25; 18(7). PMID: 22271879    Free PMC article.
Highly Cited.
Fc-γ Receptor Polymorphisms, Cetuximab Therapy, and Survival in the NCIC CTG CO.17 Trial of Colorectal Cancer.
Geoffrey Liu, Dongsheng Tu, +18 authors, Alexander Dobrovic.
Clin Cancer Res, 2016 May 15; 22(10). PMID: 27179112
Tumor-associated B7-H1 promotes T-cell apoptosis: a potential mechanism of immune evasion.
Haidong Dong, Scott E Strome, +10 authors, Lieping Chen.
Nat Med, 2002 Jul 02; 8(8). PMID: 12091876
Highly Cited.
A serious adverse event after successful gene therapy for X-linked severe combined immunodeficiency.
Salima Hacein-Bey-Abina, Christof von Kalle, +8 authors, Alain Fischer.
N Engl J Med, 2003 Jan 17; 348(3). PMID: 12529469
Highly Cited.
B-cell depletion and remissions of malignancy along with cytokine-associated toxicity in a clinical trial of anti-CD19 chimeric-antigen-receptor-transduced T cells.
James N Kochenderfer, Mark E Dudley, +15 authors, Steven A Rosenberg.
Blood, 2011 Dec 14; 119(12). PMID: 22160384    Free PMC article.
Highly Cited.
Colocalization and nonrandom distribution of Kv1.3 potassium channels and CD3 molecules in the plasma membrane of human T lymphocytes.
G Panyi, M Bagdány, +8 authors, S Damjanovich.
Proc Natl Acad Sci U S A, 2003 Feb 27; 100(5). PMID: 12604782    Free PMC article.
Regulation of human NK-cell cytokine and chemokine production by target cell recognition.
Cyril Fauriat, Eric O Long, Hans-Gustaf Ljunggren, Yenan T Bryceson.
Blood, 2009 Dec 08; 115(11). PMID: 19965656    Free PMC article.
Highly Cited.
Targeting CD123 in acute myeloid leukemia using a T-cell-directed dual-affinity retargeting platform.
Muneera Al-Hussaini, Michael P Rettig, +11 authors, John F DiPersio.
Blood, 2015 Nov 05; 127(1). PMID: 26531164    Free PMC article.
IL-2/B7.1 (CD80) fusagene transduction of AML blasts by a self-inactivating lentiviral vector stimulates T cell responses in vitro: a strategy to generate whole cell vaccines for AML.
Lucas Chan, Nicola Hardwick, +6 authors, Farzin Farzaneh.
Mol Ther, 2004 Dec 09; 11(1). PMID: 15585413
Cytokines in cancer immunity and immunotherapy.
Mark J Smyth, Erika Cretney, Michael H Kershaw, Yoshihiro Hayakawa.
Immunol Rev, 2004 Nov 18; 202. PMID: 15546400
Chimeric antigen receptor T cells persist and induce sustained remissions in relapsed refractory chronic lymphocytic leukemia.
David L Porter, Wei-Ting Hwang, +15 authors, Carl H June.
Sci Transl Med, 2015 Sep 04; 7(303). PMID: 26333935    Free PMC article.
Highly Cited.
Fc receptor-dependent mechanisms of monoclonal antibody therapy of cancer.
Jantine E Bakema, Marjolein van Egmond.
Curr Top Microbiol Immunol, 2014 Aug 15; 382. PMID: 25116109
The extracellular fluid of solid carcinomas contains immunosuppressive concentrations of adenosine.
J Blay, T D White, D W Hoskin.
Cancer Res, 1997 Jul 01; 57(13). PMID: 9205063
Highly Cited.
In vivo human somatic mutation: frequency and spectrum with age.
S A Grist, M McCarron, +2 authors, A A Morley.
Mutat Res, 1992 Apr 01; 266(2). PMID: 1373828
Gene therapy of human severe combined immunodeficiency (SCID)-X1 disease.
M Cavazzana-Calvo, S Hacein-Bey, +10 authors, A Fischer.
Science, 2000 Apr 28; 288(5466). PMID: 10784449
Highly Cited.
Tumor-infiltrating lymphocytes genetically engineered with an inducible gene encoding interleukin-12 for the immunotherapy of metastatic melanoma.
Ling Zhang, Richard A Morgan, +15 authors, Steven A Rosenberg.
Clin Cancer Res, 2015 Feb 20; 21(10). PMID: 25695689    Free PMC article.
Highly Cited.
Impact of age and environment on somatic mutation at the hprt gene of T lymphocytes in humans.
I M Jones, C B Thomas, +4 authors, D H Moore.
Mutat Res, 1995 Oct 01; 338(1-6). PMID: 7565868
Genomic expression programs and the integration of the CD28 costimulatory signal in T cell activation.
Maximilian Diehn, Ash A Alizadeh, +5 authors, Patrick O Brown.
Proc Natl Acad Sci U S A, 2002 Aug 27; 99(18). PMID: 12195013    Free PMC article.
Highly Cited.
Neoantigens in cancer immunotherapy.
Ton N Schumacher, Robert D Schreiber.
Science, 2015 Apr 04; 348(6230). PMID: 25838375
Highly Cited. Review.
The future of cancer treatment: immunomodulation, CARs and combination immunotherapy.
Danny N Khalil, Eric L Smith, Renier J Brentjens, Jedd D Wolchok.
Nat Rev Clin Oncol, 2016 Mar 16; 13(5). PMID: 26977780    Free PMC article.
Highly Cited. Review.
Tumor cell expression of programmed cell death-1 ligand 1 is a prognostic factor for malignant melanoma.
Ryosuke Hino, Kenji Kabashima, +5 authors, Yoshiki Tokura.
Cancer, 2010 Feb 10; 116(7). PMID: 20143437
Highly Cited.
Somatic mutations are frequent and increase with age in human kidney epithelial cells.
G M Martin, C E Ogburn, +3 authors, R J Monnat.
Hum Mol Genet, 1996 Feb 01; 5(2). PMID: 8824877
Fc-dependent depletion of tumor-infiltrating regulatory T cells co-defines the efficacy of anti-CTLA-4 therapy against melanoma.
Tyler R Simpson, Fubin Li, +11 authors, Sergio A Quezada.
J Exp Med, 2013 Jul 31; 210(9). PMID: 23897981    Free PMC article.
Highly Cited.
Immune suppressive mechanisms in the tumor microenvironment.
David H Munn, Vincenzo Bronte.
Curr Opin Immunol, 2015 Nov 27; 39. PMID: 26609943    Free PMC article.
Highly Cited. Review.
Regulatory T cells in tumor immunity.
Hiroyoshi Nishikawa, Shimon Sakaguchi.
Int J Cancer, 2010 Jun 03; 127(4). PMID: 20518016
Highly Cited. Review.
Regulatory T Cells in Tumor-Associated Tertiary Lymphoid Structures Suppress Anti-tumor T Cell Responses.
Nikhil S Joshi, Elliot H Akama-Garren, +11 authors, Tyler Jacks.
Immunity, 2015 Sep 06; 43(3). PMID: 26341400    Free PMC article.
Highly Cited.
Rapid accumulation of genome rearrangements in liver but not in brain of old mice.
M E Dollé, H Giese, +3 authors, J Vijg.
Nat Genet, 1997 Dec 17; 17(4). PMID: 9398844
The hallmarks of cancer.
D Hanahan, R A Weinberg.
Cell, 2000 Jan 27; 100(1). PMID: 10647931
Highly Cited. Review.
Adenosine closes the K+ channel KCa3.1 in human lung mast cells and inhibits their migration via the adenosine A2A receptor.
S Mark Duffy, Glenn Cruse, Christopher E Brightling, Peter Bradding.
Eur J Immunol, 2007 May 03; 37(6). PMID: 17474152    Free PMC article.
Enhanced T-cell immunity to osteosarcoma through antibody blockade of PD-1/PD-L1 interactions.
Danielle M Lussier, Lauren O'Neill, +7 authors, Joseph N Blattman.
J Immunother, 2015 Mar 10; 38(3). PMID: 25751499    Free PMC article.
Highly Cited.
Cell to cell interaction in the immune response. I. Hemolysin-forming cells in neonatally thymectomized mice reconstituted with thymus or thoracic duct lymphocytes.
J F Miller, G F Mitchell.
J Exp Med, 1968 Oct 01; 128(4). PMID: 5691985    Free PMC article.
Highly Cited.
CD73 on tumor cells impairs antitumor T-cell responses: a novel mechanism of tumor-induced immune suppression.
Dachuan Jin, Jie Fan, +6 authors, Bin Zhang.
Cancer Res, 2010 Feb 25; 70(6). PMID: 20179192    Free PMC article.
Highly Cited.
Identification of specific cytolytic immune responses against autologous tumor in humans bearing malignant melanoma.
L M Muul, P J Spiess, E P Director, S A Rosenberg.
J Immunol, 1987 Feb 01; 138(3). PMID: 3100623
Highly Cited.
Glycoengineered CD20 antibody obinutuzumab activates neutrophils and mediates phagocytosis through CD16B more efficiently than rituximab.
Josée Golay, Fabio Da Roit, +5 authors, Martino Introna.
Blood, 2013 Oct 10; 122(20). PMID: 24106207
Highly Cited.
Transient regulatory T cell ablation deters oncogene-driven breast cancer and enhances radiotherapy.
Paula D Bos, George Plitas, +2 authors, Alexander Y Rudensky.
J Exp Med, 2013 Oct 16; 210(11). PMID: 24127486    Free PMC article.
Highly Cited.
Potentiating the antitumour response of CD8(+) T cells by modulating cholesterol metabolism.
Wei Yang, Yibing Bai, +19 authors, Chenqi Xu.
Nature, 2016 Mar 17; 531(7596). PMID: 26982734    Free PMC article.
Highly Cited.
DNA repair and breast carcinoma susceptibility in women.
Juan M Ramos, Abigail Ruiz, +3 authors, Jaime L Matta.
Cancer, 2004 Mar 26; 100(7). PMID: 15042667
Looking through ion channels: recharged concepts in T-cell signaling.
György Panyi, György Vámosi, +2 authors, Sándor Damjanovich.
Trends Immunol, 2004 Oct 19; 25(11). PMID: 15489183
Management of immune-related adverse events and kinetics of response with ipilimumab.
Jeffrey S Weber, Katharina C Kähler, Axel Hauschild.
J Clin Oncol, 2012 May 23; 30(21). PMID: 22614989
Highly Cited. Review.
The link between MHC class I abnormalities of tumors, oncogenes, tumor suppressor genes, and transcription factors.
Barbara Seliger.
J Immunotoxicol, 2014 Feb 01; 11(4). PMID: 24479372
Germs, hosts, and the origin of Frank Macfarlane Burnet's concept of "self " and "tolerance," 1936-1949.
Hyung Wook Park.
J Hist Med Allied Sci, 2006 Jun 14; 61(4). PMID: 16769800
TGF-beta and 'adaptive' Foxp3(+) regulatory T cells.
Wanjun Chen, Joanne E Konkel.
J Mol Cell Biol, 2009 Aug 04; 2(1). PMID: 19648226    Free PMC article.
MPDL3280A (anti-PD-L1) treatment leads to clinical activity in metastatic bladder cancer.
Thomas Powles, Joseph Paul Eder, +12 authors, Nicholas J Vogelzang.
Nature, 2014 Nov 28; 515(7528). PMID: 25428503
Highly Cited.
Blockade of CTLA-4 on both effector and regulatory T cell compartments contributes to the antitumor activity of anti-CTLA-4 antibodies.
Karl S Peggs, Sergio A Quezada, +2 authors, James P Allison.
J Exp Med, 2009 Jul 08; 206(8). PMID: 19581407    Free PMC article.
Highly Cited.
A Cholesterol-Based Allostery Model of T Cell Receptor Phosphorylation.
Mahima Swamy, Katharina Beck-Garcia, +13 authors, Wolfgang W A Schamel.
Immunity, 2016 May 19; 44(5). PMID: 27192576
Highly Cited.
IL-12 release by engineered T cells expressing chimeric antigen receptors can effectively Muster an antigen-independent macrophage response on tumor cells that have shut down tumor antigen expression.
Markus Chmielewski, Caroline Kopecky, Andreas A Hombach, Hinrich Abken.
Cancer Res, 2011 Jul 12; 71(17). PMID: 21742772
Highly Cited.
IL-12 triggers a programmatic change in dysfunctional myeloid-derived cells within mouse tumors.
Sid P Kerkar, Romina S Goldszmid, +10 authors, Nicholas P Restifo.
J Clin Invest, 2011 Nov 08; 121(12). PMID: 22056381    Free PMC article.
Highly Cited.
Allogeneic IgG combined with dendritic cell stimuli induce antitumour T-cell immunity.
Yaron Carmi, Matthew H Spitzer, +9 authors, Edgar G Engleman.
Nature, 2015 Apr 30; 521(7550). PMID: 25924063    Free PMC article.
Highly Cited.
Accumulation of raft lipids in T-cell plasma membrane domains engaged in TCR signalling.
Tobias Zech, Christer S Ejsing, +4 authors, Thomas Harder.
EMBO J, 2009 Jan 30; 28(5). PMID: 19177148    Free PMC article.
Dynamic Treg interactions with intratumoral APCs promote local CTL dysfunction.
Christian A Bauer, Edward Y Kim, +3 authors, Thorsten R Mempel.
J Clin Invest, 2014 May 09; 124(6). PMID: 24812664    Free PMC article.
Highly Cited.
Eradication of B-lineage cells and regression of lymphoma in a patient treated with autologous T cells genetically engineered to recognize CD19.
James N Kochenderfer, Wyndham H Wilson, +9 authors, Steven A Rosenberg.
Blood, 2010 Jul 30; 116(20). PMID: 20668228    Free PMC article.
Highly Cited.
The role of interleukin-2 during homeostasis and activation of the immune system.
Onur Boyman, Jonathan Sprent.
Nat Rev Immunol, 2012 Feb 22; 12(3). PMID: 22343569
Highly Cited. Review.
PD-L2 is a second ligand for PD-1 and inhibits T cell activation.
Y Latchman, C R Wood, +18 authors, G J Freeman.
Nat Immunol, 2001 Feb 27; 2(3). PMID: 11224527
Highly Cited.
Selective in vitro growth of T lymphocytes from normal human bone marrows.
D A Morgan, F W Ruscetti, R Gallo.
Science, 1976 Sep 10; 193(4257). PMID: 181845
Highly Cited.
Cardiovascular toxicity and titin cross-reactivity of affinity-enhanced T cells in myeloma and melanoma.
Gerald P Linette, Edward A Stadtmauer, +20 authors, Carl H June.
Blood, 2013 Jun 19; 122(6). PMID: 23770775    Free PMC article.
Highly Cited.
Validating drug repurposing signals using electronic health records: a case study of metformin associated with reduced cancer mortality.
Hua Xu, Melinda C Aldrich, +14 authors, Joshua C Denny.
J Am Med Inform Assoc, 2014 Jul 24; 22(1). PMID: 25053577    Free PMC article.
Highly Cited.
Phase I pharmacokinetic and pharmacodynamic dose-escalation study of RG7160 (GA201), the first glycoengineered monoclonal antibody against the epidermal growth factor receptor, in patients with advanced solid tumors.
Luis G Paz-Ares, Carlos Gomez-Roca, +12 authors, Josep Tabernero.
J Clin Oncol, 2011 Sep 09; 29(28). PMID: 21900113
T Cells Expressing CD19/CD20 Bispecific Chimeric Antigen Receptors Prevent Antigen Escape by Malignant B Cells.
Eugenia Zah, Meng-Yin Lin, +2 authors, Yvonne Y Chen.
Cancer Immunol Res, 2016 Apr 10; 4(6). PMID: 27059623    Free PMC article.
Highly Cited.
Functions of natural killer cells.
Eric Vivier, Elena Tomasello, +2 authors, Sophie Ugolini.
Nat Immunol, 2008 Apr 22; 9(5). PMID: 18425107
Highly Cited. Review.
Up-regulation of PD-L1, IDO, and T(regs) in the melanoma tumor microenvironment is driven by CD8(+) T cells.
Stefani Spranger, Robbert M Spaapen, +4 authors, Thomas F Gajewski.
Sci Transl Med, 2013 Aug 30; 5(200). PMID: 23986400    Free PMC article.
Highly Cited.
Dual targeting of ErbB2 and MUC1 in breast cancer using chimeric antigen receptors engineered to provide complementary signaling.
Scott Wilkie, May C I van Schalkwyk, +7 authors, John Maher.
J Clin Immunol, 2012 Apr 25; 32(5). PMID: 22526592
Highly Cited.
Trouble at the core: BRAF(V600E) drives multiple modes of T-cell suppression in melanoma.
Sherille D Bradley, Brenda Melendez, Amjad Talukder, Gregory Lizée.
Oncoimmunology, 2016 Apr 09; 5(2). PMID: 27057458    Free PMC article.
Expression of MHC Class I on breast cancer cells correlates inversely with HER2 expression.
Masayuki Inoue, Kousaku Mimura, +13 authors, Koji Kono.
Oncoimmunology, 2012 Nov 22; 1(7). PMID: 23170258    Free PMC article.
LMO2-associated clonal T cell proliferation in two patients after gene therapy for SCID-X1.
S Hacein-Bey-Abina, C Von Kalle, +32 authors, M Cavazzana-Calvo.
Science, 2003 Oct 18; 302(5644). PMID: 14564000
Highly Cited.
Hematopoietic stem cells express multiple myeloid markers: implications for the origin and targeted therapy of acute myeloid leukemia.
David C Taussig, Daniel J Pearce, +6 authors, Dominique Bonnet.
Blood, 2005 Sep 01; 106(13). PMID: 16131573    Free PMC article.
Deconstructing the form and function of the TCR/CD3 complex.
Michael S Kuhns, Mark M Davis, K Christopher Garcia.
Immunity, 2006 Feb 14; 24(2). PMID: 16473826
Adoptive cell transfer as personalized immunotherapy for human cancer.
Steven A Rosenberg, Nicholas P Restifo.
Science, 2015 Apr 04; 348(6230). PMID: 25838374    Free PMC article.
Highly Cited. Review.
The Ca(2+)-activated K(+) channel KCa3.1 compartmentalizes in the immunological synapse of human T lymphocytes.
Stella A Nicolaou, Lisa Neumeier, +2 authors, Laura Conforti.
Am J Physiol Cell Physiol, 2006 Dec 08; 292(4). PMID: 17151145    Free PMC article.
Chimeric antigen receptor-modified T cells for acute lymphoid leukemia.
Stephan A Grupp, Michael Kalos, +10 authors, Carl H June.
N Engl J Med, 2013 Mar 27; 368(16). PMID: 23527958    Free PMC article.
Highly Cited.
Kv1.3 potassium channels are localized in the immunological synapse formed between cytotoxic and target cells.
G Panyi, G Vámosi, +6 authors, S Damjanovich.
Proc Natl Acad Sci U S A, 2004 Jan 28; 101(5). PMID: 14745040    Free PMC article.
Ion channels and transporters in lymphocyte function and immunity.
Stefan Feske, Edward Y Skolnik, Murali Prakriya.
Nat Rev Immunol, 2012 Jun 16; 12(7). PMID: 22699833    Free PMC article.
Highly Cited. Review.
Interleukin-12 in anti-tumor immunity and immunotherapy.
Mario P Colombo, Giorgio Trinchieri.
Cytokine Growth Factor Rev, 2002 Mar 20; 13(2). PMID: 11900991
Highly Cited. Review.
Downregulation of HLA class I expression by c-myc in human melanoma is independent of enhancer A.
L T Peltenburg, R Dee, P I Schrier.
Nucleic Acids Res, 1993 Mar 11; 21(5). PMID: 8464702    Free PMC article.
CTLA-4 and PD-1/PD-L1 blockade: new immunotherapeutic modalities with durable clinical benefit in melanoma patients.
Patrick A Ott, F Stephen Hodi, Caroline Robert.
Clin Cancer Res, 2013 Oct 04; 19(19). PMID: 24089443
Highly Cited. Review.
A phase I clinical trial of adoptive T cell therapy using IL-12 secreting MUC-16(ecto) directed chimeric antigen receptors for recurrent ovarian cancer.
Mythili Koneru, Roisin O'Cearbhaill, +2 authors, Renier J Brentjens.
J Transl Med, 2015 Apr 19; 13. PMID: 25890361    Free PMC article.
Highly Cited.
CD274/PD-L1 gene amplification and PD-L1 protein expression are common events in squamous cell carcinoma of the oral cavity.
Melanie Straub, Enken Drecoll, +7 authors, Katja Specht.
Oncotarget, 2016 Feb 27; 7(11). PMID: 26918453    Free PMC article.
Highly Cited.
Tumor-Induced Myeloid-Derived Suppressor Cells.
Francesco De Sanctis, Vincenzo Bronte, Stefano Ugel.
Microbiol Spectr, 2016 Jun 24; 4(3). PMID: 27337449
Targeting the PD-1/B7-H1(PD-L1) pathway to activate anti-tumor immunity.
Suzanne L Topalian, Charles G Drake, Drew M Pardoll.
Curr Opin Immunol, 2012 Jan 13; 24(2). PMID: 22236695    Free PMC article.
Highly Cited. Review.
Selective inhibition of KCa3.1 channels mediates adenosine regulation of the motility of human T cells.
Ameet A Chimote, Peter Hajdu, +5 authors, Laura Conforti.
J Immunol, 2013 Nov 15; 191(12). PMID: 24227782    Free PMC article.
Monoclonal antibody G 250 recognizes a determinant present in renal-cell carcinoma and absent from normal kidney.
E Oosterwijk, D J Ruiter, +4 authors, S O Warnaar.
Int J Cancer, 1986 Oct 15; 38(4). PMID: 2428759
Highly Cited.
Immune-mediated antitumor effect by type 2 diabetes drug, metformin.
Shingo Eikawa, Mikako Nishida, +3 authors, Heiichiro Udono.
Proc Natl Acad Sci U S A, 2015 Jan 28; 112(6). PMID: 25624476    Free PMC article.
Highly Cited.
Tumor-derived exosomes in colorectal cancer progression and their clinical applications.
Jianbiao Zhou, Xiao-Lan Li, Zhi-Rong Chen, Wee-Joo Chng.
Oncotarget, 2017 Dec 17; 8(59). PMID: 29246022    Free PMC article.
Combination Strategies Using EGFR-TKi in NSCLC Therapy: Learning from the Gap between Pre-Clinical Results and Clinical Outcomes.
Zheng Yang, Kin Yip Tam.
Int J Biol Sci, 2018 Feb 28; 14(2). PMID: 29483838    Free PMC article.
The role of neoantigen in immune checkpoint blockade therapy.
Ming Yi, Shuang Qin, +3 authors, Kongming Wu.
Exp Hematol Oncol, 2018 Nov 27; 7. PMID: 30473928    Free PMC article.
Highly Cited. Review.
Immune Checkpoint Inhibitor Toxicity in Head and Neck Cancer: From Identification to Management.
Haiyang Wang, Abdulkadir Mustafa, +4 authors, Jian Zou.
Front Pharmacol, 2019 Nov 12; 10. PMID: 31708780    Free PMC article.
Inhibition of mTOR complex 1/p70 S6 kinase signaling elevates PD-L1 levels in human cancer cells through enhancing protein stabilization accompanied with enhanced β-TrCP degradation.
Liang Deng, Guoqing Qian, +6 authors, Shi-Yong Sun.
Oncogene, 2019 Jul 19; 38(35). PMID: 31316145
Cellular immunotherapies for cancer.
Conall Hayes.
Ir J Med Sci, 2020 Jul 02; 190(1). PMID: 32607912    Free PMC article.
Extracellular Vesicles Mediate B Cell Immune Response and Are a Potential Target for Cancer Therapy.
Taketo Kato, Johannes F Fahrmann, Samir M Hanash, Jody Vykoukal.
Cells, 2020 Jun 26; 9(6). PMID: 32580358    Free PMC article.
Development of an intravital imaging system for the synovial tissue reveals the dynamics of CTLA-4 Ig in vivo.
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Jane Cullis, Shipra Das, Dafna Bar-Sagi.
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Shi-Yong Sun.
Transl Oncol, 2020 Aug 28; 13(12). PMID: 32854033    Free PMC article.
Editorial: Cancer Plasticity and the Microenvironment: Implications for Immunity and Therapy Response.
Andreas Behren, Erik W Thompson, Robin L Anderson, Petranel T Ferrao.
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Nanobody Engineering: Toward Next Generation Immunotherapies and Immunoimaging of Cancer.
Timothée Chanier, Patrick Chames.
Antibodies (Basel), 2019 Sep 24; 8(1). PMID: 31544819    Free PMC article.
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Tumor Vessel Normalization: A Window to Enhancing Cancer Immunotherapy.
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Technol Cancer Res Treat, 2020 Dec 09; 19. PMID: 33287656    Free PMC article.
Peripheral cytotoxic T lymphocyte predicts first-line progression free survival in HER2-positive advanced breast cancer.
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Breast, 2020 Dec 10; 55. PMID: 33296767    Free PMC article.
mTOR-targeted cancer therapy: great target but disappointing clinical outcomes, why?
Shi-Yong Sun.
Front Med, 2020 Nov 10; 15(2). PMID: 33165737
Tipping the Scales With Zebrafish to Understand Adaptive Tumor Immunity.
Kelly Z Miao, Grace Y Kim, +2 authors, Hui Feng.
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The Mechanism of Stimulating and Mobilizing the Immune System Enhancing the Anti-Tumor Immunity.
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