Review
. 2017 Apr; 35:285-311.
doi: 10.1146/annurev-immunol-051116-052433.

Signaling by Antibodies: Recent Progress

Stylianos Bournazos 1 Taia T Wang 1 Rony Dahan 1 Jad Maamary 1 Jeffrey V Ravetch 1 
Affiliations
  • PMID: 28446061
  •     148 References
  •     74 citations

Abstract

IgG antibodies mediate a diversity of immune functions by coupling of antigen specificity through the Fab domain to signal transduction via Fc-Fc receptor interactions. Indeed, balanced IgG signaling through type I and type II Fc receptors is required for the control of proinflammatory, anti-inflammatory, and immunomodulatory processes. In this review, we discuss the mechanisms that govern IgG-Fc receptor interactions, highlighting the diversity of Fc receptor-mediated effector functions that regulate immunity and inflammation as well as determine susceptibility to infection and autoimmunity and responsiveness to antibody-based therapeutics and vaccines.

Keywords: Fc receptors; IgG; effector function; immunity; immunomodulation; inflammation.

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Virology, 2002 Mar 12; 294(1). PMID: 11886266
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Immunoglobulin G galactosylation and sialylation are associated with pregnancy-induced improvement of rheumatoid arthritis and the postpartum flare: results from a large prospective cohort study.
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Endogenous antibody responses to mucin 1 in a large multiethnic cohort of patients with breast cancer and healthy controls: Role of immunoglobulin and Fcγ receptor genes.
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Hum Immunol, 2018 Jun 08; 79(8). PMID: 29879453    Free PMC article.
MIgGGly (mouse IgG glycosylation analysis) - a high-throughput method for studying Fc-linked IgG N-glycosylation in mice with nanoUPLC-ESI-MS.
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Sci Rep, 2018 Sep 14; 8(1). PMID: 30209257    Free PMC article.
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Proc Natl Acad Sci U S A, 2019 Sep 06; 116(40). PMID: 31484758    Free PMC article.
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CD32 Ligation Promotes the Activation of CD4+ T Cells.
María Pía Holgado, Inés Sananez, +2 authors, Lourdes Arruvito.
Front Immunol, 2018 Dec 18; 9. PMID: 30555482    Free PMC article.
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Nat Commun, 2019 Sep 29; 10(1). PMID: 31562320    Free PMC article.
CD22 Expression in B-Cell Acute Lymphoblastic Leukemia: Biological Significance and Implications for Inotuzumab Therapy in Adults.
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Front Immunol, 2019 Jul 30; 10. PMID: 31354709    Free PMC article.
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The Diverse Functions of the Ubiquitous Fcγ Receptors and Their Unique Constituent, FcRγ Subunit.
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The Glycosylation Site of Myelin Oligodendrocyte Glycoprotein Affects Autoantibody Recognition in a Large Proportion of Patients.
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Front Immunol, 2019 Jun 28; 10. PMID: 31244828    Free PMC article.
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ImmunoPET: Concept, Design, and Applications.
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medRxiv, 2020 Jun 09;. PMID: 32511463    Free PMC article.
FcRn, but not FcγRs, drives maternal-fetal transplacental transport of human IgG antibodies.
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Proc Natl Acad Sci U S A, 2020 May 29; 117(23). PMID: 32461366    Free PMC article.
Opsonization-Enhanced Antigen Presentation by MR1 Activates Rapid Polyfunctional MAIT Cell Responses Acting as an Effector Arm of Humoral Antibacterial Immunity.
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J Immunol, 2020 May 22; 205(1). PMID: 32434941    Free PMC article.
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Highly Cited. Review.
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Maternal Anti-Dengue IgG Fucosylation Predicts Susceptibility to Dengue Disease in Infants.
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Cell Rep, 2020 May 14; 31(6). PMID: 32402275    Free PMC article.
Combined Anti-Cancer Strategies Based on Anti-Checkpoint Inhibitor Antibodies.
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Genetic signature of prostate cancer mouse models resistant to optimized hK2 targeted α-particle therapy.
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Proc Natl Acad Sci U S A, 2020 Jun 14; 117(26). PMID: 32532924    Free PMC article.
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Immunoglobulins with Non-Canonical Functions in Inflammatory and Autoimmune Disease States.
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Systematic Review.
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FcRn is a CD32a coreceptor that determines susceptibility to IgG immune complex-driven autoimmunity.
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Fc-Engineered Antibodies with Enhanced Fc-Effector Function for the Treatment of B-Cell Malignancies.
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Fc-optimized antibodies elicit CD8 immunity to viral respiratory infection.
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Activated Platelets Convert CD14+CD16- Into CD14+CD16+ Monocytes With Enhanced FcγR-Mediated Phagocytosis and Skewed M2 Polarization.
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Front Immunol, 2021 Feb 12; 11. PMID: 33569066    Free PMC article.
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Sialylated immunoglobulin G: a promising diagnostic and therapeutic strategy for autoimmune diseases.
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Improved HIV-positive infant survival is correlated with high levels of HIV-specific ADCC activity in multiple cohorts.
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Vectored Immunotherapeutics for Infectious Diseases: Can rAAVs Be The Game Changers for Fighting Transmissible Pathogens?
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On the Use of Surface Plasmon Resonance Biosensing to Understand IgG-FcγR Interactions.
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Antibody fucosylation predicts disease severity in secondary dengue infection.
Stylianos Bournazos, Hoa Thi My Vo, +6 authors, Jeffrey V Ravetch.
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Fc Gamma Receptors as Regulators of Bone Destruction in Inflammatory Arthritis.
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Systematic Review.
Antibody Subclass and Glycosylation Shift Following Effective TB Treatment.
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Front Immunol, 2021 Jul 23; 12. PMID: 34290702    Free PMC article.
Contribution of Antibody-Mediated Effector Functions to the Mechanism of Efficacy of Vaccines for Opioid Use Disorders.
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Cross-Linking Cellular Prion Protein Induces Neuronal Type 2-Like Hypersensitivity.
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Francisella and Antibodies.
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MICA/B antibody induces macrophage-mediated immunity against acute myeloid leukemia.
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Targeting NK Cells for HIV-1 Treatment and Reservoir Clearance.
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Sialylation as an Important Regulator of Antibody Function.
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