. 2017 Apr; 35:285-311.
doi: 10.1146/annurev-immunol-051116-052433.

Signaling by Antibodies: Recent Progress

Stylianos Bournazos 1 Taia T Wang 1 Rony Dahan 1 Jad Maamary 1 Jeffrey V Ravetch 1 
  • PMID: 28446061
  •     148 References
  •     74 citations


IgG antibodies mediate a diversity of immune functions by coupling of antigen specificity through the Fab domain to signal transduction via Fc-Fc receptor interactions. Indeed, balanced IgG signaling through type I and type II Fc receptors is required for the control of proinflammatory, anti-inflammatory, and immunomodulatory processes. In this review, we discuss the mechanisms that govern IgG-Fc receptor interactions, highlighting the diversity of Fc receptor-mediated effector functions that regulate immunity and inflammation as well as determine susceptibility to infection and autoimmunity and responsiveness to antibody-based therapeutics and vaccines.

Keywords: Fc receptors; IgG; effector function; immunity; immunomodulation; inflammation.

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Opsonization-Enhanced Antigen Presentation by MR1 Activates Rapid Polyfunctional MAIT Cell Responses Acting as an Effector Arm of Humoral Antibacterial Immunity.
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Fc-optimized antibodies elicit CD8 immunity to viral respiratory infection.
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Development of antibody-dependent cell cytotoxicity function in HIV-1 antibodies.
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Sialylated immunoglobulin G: a promising diagnostic and therapeutic strategy for autoimmune diseases.
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Improved HIV-positive infant survival is correlated with high levels of HIV-specific ADCC activity in multiple cohorts.
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Vectored Immunotherapeutics for Infectious Diseases: Can rAAVs Be The Game Changers for Fighting Transmissible Pathogens?
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Fc-engineered antibody therapeutics with improved efficacy against COVID-19.
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Sialylation as an Important Regulator of Antibody Function.
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