Journal Article
. 2017 May; 8:513.
doi: 10.3389/fimmu.2017.00513.

Comparative Analysis of Immune Checkpoint Molecules and Their Potential Role in the Transmissible Tasmanian Devil Facial Tumor Disease

Andrew S Flies 1 Nicholas B Blackburn 1 Alan Bruce Lyons 2 John D Hayball 3 Gregory M Woods 1 
Affiliations
  • PMID: 28515726
  •     211 References
  •     7 citations

Abstract

Immune checkpoint molecules function as a system of checks and balances that enhance or inhibit immune responses to infectious agents, foreign tissues, and cancerous cells. Immunotherapies that target immune checkpoint molecules, particularly the inhibitory molecules programmed cell death 1 and cytotoxic T-lymphocyte-associated protein 4 (CTLA-4), have revolutionized human oncology in recent years, yet little is known about these key immune signaling molecules in species other than primates and rodents. The Tasmanian devil facial tumor disease is caused by transmissible cancers that have resulted in a massive decline in the wild Tasmanian devil population. We have recently demonstrated that the inhibitory checkpoint molecule PD-L1 is upregulated on Tasmanian devil (Sarcophilus harrisii) facial tumor cells in response to the interferon-gamma cytokine. As this could play a role in immune evasion by tumor cells, we performed a thorough comparative analysis of checkpoint molecule protein sequences among Tasmanian devils and eight other species. We report that many of the key signaling motifs and ligand-binding sites in the checkpoint molecules are highly conserved across the estimated 162 million years of evolution since the last common ancestor of placental and non-placental mammals. Specifically, we discovered that the CTLA-4 (MYPPPY) ligand-binding motif and the CTLA-4 (GVYVKM) inhibitory domain are completely conserved across all nine species used in our comparative analysis, suggesting that the function of CTLA-4 is likely conserved in these species. We also found that cysteine residues for intra- and intermolecular disulfide bonds were also highly conserved. For instance, all 20 cysteine residues involved in disulfide bonds in the human 4-1BB molecule were also present in devil 4-1BB. Although many key sequences were conserved, we have also identified immunoreceptor tyrosine-based inhibitory motifs (ITIMs) and immunoreceptor tyrosine-based switch motifs (ITSMs) in genes and protein domains that have not been previously reported in any species. This checkpoint molecule analysis and review of salient features for each of the molecules presented here can serve as road map for the development of a Tasmanian devil facial tumor disease immunotherapy. Finally, the strategies can be used as a guide for veterinarians, ecologists, and other researchers willing to venture into the nascent field of wild immunology.

Keywords: allograft; checkpoint blockade; cosignaling immunotherapy; devil; evolution; transmissible tumor; transplant rejection; wild immunity.

CD47(high) expression on CD4 effectors identifies functional long-lived memory T cell progenitors.
Vu Quang Van, Marianne Raymond, +4 authors, Marika Sarfati.
J Immunol, 2012 Mar 31; 188(9). PMID: 22461697
Nivolumab plus ipilimumab in advanced melanoma.
Jedd D Wolchok, Harriet Kluger, +21 authors, Mario Sznol.
N Engl J Med, 2013 Jun 04; 369(2). PMID: 23724867    Free PMC article.
Highly Cited.
CEACAM1 regulates TIM-3-mediated tolerance and exhaustion.
Yu-Hwa Huang, Chen Zhu, +21 authors, Richard S Blumberg.
Nature, 2014 Nov 05; 517(7534). PMID: 25363763    Free PMC article.
Highly Cited.
Binding of the B cell activation antigen B7 to CD28 costimulates T cell proliferation and interleukin 2 mRNA accumulation.
P S Linsley, W Brady, +3 authors, J A Ledbetter.
J Exp Med, 1991 Mar 01; 173(3). PMID: 1847722    Free PMC article.
Highly Cited.
Identification of tyrosine residues crucial for CD200R-mediated inhibition of mast cell activation.
Shuli Zhang, Joseph H Phillips.
J Leukoc Biol, 2005 Dec 07; 79(2). PMID: 16330532
Fast, scalable generation of high-quality protein multiple sequence alignments using Clustal Omega.
Fabian Sievers, Andreas Wilm, +9 authors, Desmond G Higgins.
Mol Syst Biol, 2011 Oct 13; 7. PMID: 21988835    Free PMC article.
Highly Cited.
Expression of PD-L1 on canine tumor cells and enhancement of IFN-γ production from tumor-infiltrating cells by PD-L1 blockade.
Naoya Maekawa, Satoru Konnai, +8 authors, Kazuhiko Ohashi.
PLoS One, 2014 Jun 11; 9(6). PMID: 24915569    Free PMC article.
A receptor induced by lymphocyte activation (ILA): a new member of the human nerve-growth-factor/tumor-necrosis-factor receptor family.
H Schwarz, J Tuckwell, M Lotz.
Gene, 1993 Dec 08; 134(2). PMID: 8262389
Relationship between B7-H4, regulatory T cells, and patient outcome in human ovarian carcinoma.
Ilona Kryczek, Shuang Wei, +6 authors, Weiping Zou.
Cancer Res, 2007 Sep 19; 67(18). PMID: 17875732
Highly Cited.
CD28-mediated signalling co-stimulates murine T cells and prevents induction of anergy in T-cell clones.
F A Harding, J G McArthur, +2 authors, J P Allison.
Nature, 1992 Apr 16; 356(6370). PMID: 1313950
Highly Cited.
CD200 expression suppresses natural killer cell function and directly inhibits patient anti-tumor response in acute myeloid leukemia.
S J Coles, E C Y Wang, +4 authors, R L Darley.
Leukemia, 2011 Jan 29; 25(5). PMID: 21274000    Free PMC article.
CD3/TCR complex-associated lymphocyte activation gene-3 molecules inhibit CD3/TCR signaling.
S Hannier, M Tournier, G Bismuth, F Triebel.
J Immunol, 1998 Oct 21; 161(8). PMID: 9780176
The role of cis dimerization of signal regulatory protein alpha (SIRPalpha) in binding to CD47.
Winston Y Lee, Dominique A Weber, +5 authors, Charles A Parkos.
J Biol Chem, 2010 Sep 10; 285(49). PMID: 20826801    Free PMC article.
The singular history of a canine transmissible tumor.
Bridgett M VonHoldt, Elaine A Ostrander.
Cell, 2006 Aug 12; 126(3). PMID: 16901777
Review.
Identification of natural killer cell receptor genes in the genome of the marsupial Tasmanian devil (Sarcophilus harrisii).
Lauren E van der Kraan, Emily S W Wong, +2 authors, Katherine Belov.
Immunogenetics, 2012 Sep 26; 65(1). PMID: 23007952
Integrin-associated protein (CD47) and its ligands.
E J Brown, W A Frazier.
Trends Cell Biol, 2001 Apr 18; 11(3). PMID: 11306274
Highly Cited. Review.
Paired receptor specificity explained by structures of signal regulatory proteins alone and complexed with CD47.
Deborah Hatherley, Stephen C Graham, +3 authors, A Neil Barclay.
Mol Cell, 2008 Jul 29; 31(2). PMID: 18657508
Ensembl 2017.
Bronwen L Aken, Premanand Achuthan, +47 authors, Paul Flicek.
Nucleic Acids Res, 2016 Dec 03; 45(D1). PMID: 27899575    Free PMC article.
Highly Cited.
CD200 Expression on Plasma Cell Myeloma Cells is Associated with the Efficacies of Bortezomib, Lenalidomide and Thalidomide.
Sakiko Tazawa, Eisuke Shiozawa, +10 authors, Masafumi Takimoto.
J Clin Exp Hematop, 2016 Jan 15; 55(3). PMID: 26763359
Trogocytosis of CD80 and CD86 by induced regulatory T cells.
Peng Gu, Julia Fang Gao, +3 authors, Li Zhang.
Cell Mol Immunol, 2012 Feb 07; 9(2). PMID: 22307040    Free PMC article.
The binding site for TRAF2 and TRAF3 but not for TRAF6 is essential for CD40-mediated immunoglobulin class switching.
Haifa Jabara, Dhafer Laouini, +7 authors, Raif Geha.
Immunity, 2002 Oct 02; 17(3). PMID: 12354380
Soluble programmed death-ligand 1 as a prognostic biomarker for overall survival in patients with diffuse large B-cell lymphoma: a replication study and combined analysis of 508 patients.
D Rossille, I Azzaoui, +15 authors, T Fest.
Leukemia, 2016 Dec 31; 31(4). PMID: 28035137    Free PMC article.
Structure of signal-regulatory protein alpha: a link to antigen receptor evolution.
Deborah Hatherley, Stephen C Graham, +2 authors, A Neil Barclay.
J Biol Chem, 2009 Jul 25; 284(39). PMID: 19628875    Free PMC article.
Cancer immunotherapy in veterinary medicine: Current options and new developments.
Daniel Regan, Amanda Guth, Jonathan Coy, Steven Dow.
Vet J, 2015 Nov 08; 207. PMID: 26545847
Review.
CD28 and CTLA-4 coreceptor expression and signal transduction.
Christopher E Rudd, Alison Taylor, Helga Schneider.
Immunol Rev, 2009 May 12; 229(1). PMID: 19426212    Free PMC article.
Highly Cited. Review.
Immune regulation of canine tumour and macrophage PD-L1 expression.
G Hartley, E Faulhaber, +5 authors, S Dow.
Vet Comp Oncol, 2016 Feb 05; 15(2). PMID: 26842912
Extranodal dissemination of non-Hodgkin lymphoma requires CD47 and is inhibited by anti-CD47 antibody therapy.
Mark P Chao, Chad Tang, +3 authors, Irving L Weissman.
Blood, 2011 Aug 11; 118(18). PMID: 21828138    Free PMC article.
SMART: recent updates, new developments and status in 2015.
Ivica Letunic, Tobias Doerks, Peer Bork.
Nucleic Acids Res, 2014 Oct 11; 43(Database issue). PMID: 25300481    Free PMC article.
Highly Cited.
Triggering of natural killer cells by the costimulatory molecule CD80 (B7-1)
B J Chambers, M Salcedo, H G Ljunggren.
Immunity, 1996 Oct 01; 5(4). PMID: 8885864
Survival and function of CD47-deficient thymic grafts in mice.
Yuantao Wang, Hui Wang, +2 authors, Yong-Guang Yang.
Xenotransplantation, 2010 Jun 05; 17(2). PMID: 20522249    Free PMC article.
CD47 is upregulated on circulating hematopoietic stem cells and leukemia cells to avoid phagocytosis.
Siddhartha Jaiswal, Catriona H M Jamieson, +6 authors, Irving L Weissman.
Cell, 2009 Jul 28; 138(2). PMID: 19632178    Free PMC article.
Highly Cited.
A soluble form of CD80 enhances antitumor immunity by neutralizing programmed death ligand-1 and simultaneously providing costimulation.
Samuel T Haile, Lucas A Horn, Suzanne Ostrand-Rosenberg.
Cancer Immunol Res, 2014 May 14; 2(7). PMID: 24819296    Free PMC article.
The kinetic-segregation model: TCR triggering and beyond.
Simon J Davis, P Anton van der Merwe.
Nat Immunol, 2006 Jul 21; 7(8). PMID: 16855606
Highly Cited. Review.
Lymphocyte activation gene-3 induces tumor regression and antitumor immune responses.
P Prigent, S El Mir, M Dréano, F Triebel.
Eur J Immunol, 1999 Dec 22; 29(12). PMID: 10601994
The CD47-signal regulatory protein alpha (SIRPa) interaction is a therapeutic target for human solid tumors.
Stephen B Willingham, Jens-Peter Volkmer, +41 authors, Irving L Weissman.
Proc Natl Acad Sci U S A, 2012 Mar 28; 109(17). PMID: 22451913    Free PMC article.
Highly Cited.
Programmed death-1 ligand 1 interacts specifically with the B7-1 costimulatory molecule to inhibit T cell responses.
Manish J Butte, Mary E Keir, +2 authors, Gordon J Freeman.
Immunity, 2007 Jul 17; 27(1). PMID: 17629517    Free PMC article.
Highly Cited.
Graft-infiltrating cells expressing a CD200 transgene prolong allogeneic skin graft survival in association with local increases in Foxp3(+)Treg and mast cells.
Reginald M Gorczynski, Zhiqi Chen, Ismat Khatri, Kai Yu.
Transpl Immunol, 2011 Aug 02; 25(4). PMID: 21801836
The TNF receptor-ligands 4-1BB-4-1BBL and GITR-GITRL in NK cell responses.
Isabel Barao.
Front Immunol, 2013 Jan 15; 3. PMID: 23316193    Free PMC article.
CD137 in NK cells.
Jacqueline Marvel, Thierry Walzer.
Blood, 2010 Apr 17; 115(15). PMID: 20395422
A greedy algorithm for aligning DNA sequences.
Z Zhang, S Schwartz, L Wagner, W Miller.
J Comput Biol, 2000 Jul 13; 7(1-2). PMID: 10890397
Highly Cited.
IL-15-dependent induction of 4-1BB promotes antigen-independent CD8 memory T cell survival.
Gayle Pulle, Mariana Vidric, Tania H Watts.
J Immunol, 2006 Feb 24; 176(5). PMID: 16493029
Human signal-regulatory protein is expressed on normal, but not on subsets of leukemic myeloid cells and mediates cellular adhesion involving its counterreceptor CD47.
M Seiffert, C Cant, +6 authors, H J Bühring.
Blood, 1999 Nov 26; 94(11). PMID: 10572074
Beyond CTLA-4 and PD-1, the Generation Z of Negative Checkpoint Regulators.
Isabelle Le Mercier, J Louise Lines, Randolph J Noelle.
Front Immunol, 2015 Sep 09; 6. PMID: 26347741    Free PMC article.
Highly Cited. Review.
Tumor-infiltrating DCs suppress nucleic acid-mediated innate immune responses through interactions between the receptor TIM-3 and the alarmin HMGB1.
Shigeki Chiba, Muhammad Baghdadi, +12 authors, Masahisa Jinushi.
Nat Immunol, 2012 Jul 31; 13(9). PMID: 22842346    Free PMC article.
Highly Cited.
Solution structure of human CTLA-4 and delineation of a CD80/CD86 binding site conserved in CD28.
W J Metzler, J Bajorath, +8 authors, P S Linsley.
Nat Struct Biol, 1997 Jul 01; 4(7). PMID: 9228944
The human genome browser at UCSC.
W James Kent, Charles W Sugnet, +4 authors, David Haussler.
Genome Res, 2002 Jun 05; 12(6). PMID: 12045153    Free PMC article.
Highly Cited.
Programmed Cell Death Ligand 1 Expression in Canine Cancer.
Kazuha Shosu, Masashi Sakurai, +6 authors, Takuya Mizuno.
In Vivo, 2016 Apr 24; 30(3). PMID: 27107075
Therapeutic antibody targeting of CD47 eliminates human acute lymphoblastic leukemia.
Mark P Chao, Ash A Alizadeh, +6 authors, Ravindra Majeti.
Cancer Res, 2010 Dec 24; 71(4). PMID: 21177380    Free PMC article.
Highly Cited.
Engineered SIRPα variants as immunotherapeutic adjuvants to anticancer antibodies.
Kipp Weiskopf, Aaron M Ring, +8 authors, K Christopher Garcia.
Science, 2013 Jun 01; 341(6141). PMID: 23722425    Free PMC article.
Highly Cited.
The English strain of rat cytomegalovirus (CMV) contains a novel captured CD200 (vOX2) gene and a spliced CC chemokine upstream from the major immediate-early region: further evidence for a separate evolutionary lineage from that of rat CMV Maastricht.
Sebastian Voigt, Gordon R Sandford, Gary S Hayward, William H Burns.
J Gen Virol, 2005 Jan 22; 86(Pt 2). PMID: 15659745
Myelin down-regulates myelin phagocytosis by microglia and macrophages through interactions between CD47 on myelin and SIRPα (signal regulatory protein-α) on phagocytes.
Miri Gitik, Sigal Liraz-Zaltsman, +2 authors, Shlomo Rotshenker.
J Neuroinflammation, 2011 Mar 16; 8. PMID: 21401967    Free PMC article.
TIM-3 expression characterizes regulatory T cells in tumor tissues and is associated with lung cancer progression.
Xin Gao, Yibei Zhu, +7 authors, Binfeng Lu.
PLoS One, 2012 Mar 01; 7(2). PMID: 22363469    Free PMC article.
Highly Cited.
Nivolumab and ipilimumab versus ipilimumab in untreated melanoma.
Michael A Postow, Jason Chesney, +18 authors, F Stephen Hodi.
N Engl J Med, 2015 Apr 22; 372(21). PMID: 25891304    Free PMC article.
Highly Cited.
Persistence of gene expression profile in CD200 transgenic skin allografts is associated with graft survival on retransplantation to normal recipients.
Kai Yu, Reginald M Gorczynski.
Transplantation, 2012 Jun 12; 94(1). PMID: 22683854
Short cytoplasmic SDYMNM segment of CD28 is sufficient to convert CTLA-4 to a positive signaling receptor.
Li Yin, Helga Schneider, Christopher E Rudd.
J Leukoc Biol, 2003 Jan 15; 73(1). PMID: 12525576
Phosphotyrosine-dependent coupling of Tim-3 to T-cell receptor signaling pathways.
Judong Lee, Ee Wern Su, +6 authors, Lawrence P Kane.
Mol Cell Biol, 2011 Aug 03; 31(19). PMID: 21807895    Free PMC article.
Costimulatory TNFR family members in control of viral infection: outstanding questions.
Achire N Mbanwi, Tania H Watts.
Semin Immunol, 2014 Jun 10; 26(3). PMID: 24910294
CD28 delivers a costimulatory signal involved in antigen-specific IL-2 production by human T cells.
M K Jenkins, P S Taylor, S D Norton, K B Urdahl.
J Immunol, 1991 Oct 15; 147(8). PMID: 1717561
Highly Cited.
CD47 is an adverse prognostic factor and therapeutic antibody target on human acute myeloid leukemia stem cells.
Ravindra Majeti, Mark P Chao, +5 authors, Irving L Weissman.
Cell, 2009 Jul 28; 138(2). PMID: 19632179    Free PMC article.
Highly Cited.
Inhibitory B7-family molecules in the tumour microenvironment.
Weiping Zou, Lieping Chen.
Nat Rev Immunol, 2008 May 27; 8(6). PMID: 18500231
Highly Cited. Review.
SMART, a simple modular architecture research tool: identification of signaling domains.
J Schultz, F Milpetz, P Bork, C P Ponting.
Proc Natl Acad Sci U S A, 1998 May 30; 95(11). PMID: 9600884    Free PMC article.
Highly Cited.
Cytomegalovirus e127 protein interacts with the inhibitory CD200 receptor.
Mildred Foster-Cuevas, Tina Westerholt, +3 authors, Sebastian Voigt.
J Virol, 2011 Apr 08; 85(12). PMID: 21471232    Free PMC article.
Human lymphocytes interact directly with CD47 through a novel member of the signal regulatory protein (SIRP) family.
Gary Brooke, Joanna D Holbrook, Marion H Brown, A Neil Barclay.
J Immunol, 2004 Aug 06; 173(4). PMID: 15294972
The surface protein TIGIT suppresses T cell activation by promoting the generation of mature immunoregulatory dendritic cells.
Xin Yu, Kristin Harden, +9 authors, Jane L Grogan.
Nat Immunol, 2008 Nov 18; 10(1). PMID: 19011627
Highly Cited.
Durable antitumor responses to CD47 blockade require adaptive immune stimulation.
Jonathan T Sockolosky, Michael Dougan, +5 authors, K Christopher Garcia.
Proc Natl Acad Sci U S A, 2016 Apr 20; 113(19). PMID: 27091975    Free PMC article.
Highly Cited.
Blockade of the 4-1BB (CD137)/4-1BBL and/or CD28/CD80/CD86 costimulatory pathways promotes corneal allograft survival in mice.
Tatsuhiko Asai, Beom K Choi, +5 authors, Byoung S Kwon.
Immunology, 2007 Mar 23; 121(3). PMID: 17376197    Free PMC article.
Clonal origin and evolution of a transmissible cancer.
Claudio Murgia, Jonathan K Pritchard, +2 authors, Robin A Weiss.
Cell, 2006 Aug 12; 126(3). PMID: 16901782    Free PMC article.
Recombinant CD200 protein does not bind activating proteins closely related to CD200 receptor.
Deborah Hatherley, Holly M Cherwinski, Mehrdad Moshref, A Neil Barclay.
J Immunol, 2005 Aug 06; 175(4). PMID: 16081818
SignalP 4.0: discriminating signal peptides from transmembrane regions.
Thomas Nordahl Petersen, Søren Brunak, Gunnar von Heijne, Henrik Nielsen.
Nat Methods, 2011 Oct 01; 8(10). PMID: 21959131
Highly Cited.
Anti-CTLA-4 therapy broadens the melanoma-reactive CD8+ T cell response.
Pia Kvistborg, Daisy Philips, +13 authors, Ton N Schumacher.
Sci Transl Med, 2014 Sep 19; 6(254). PMID: 25232180
Highly Cited.
Progressive sequence alignment as a prerequisite to correct phylogenetic trees.
D F Feng, R F Doolittle.
J Mol Evol, 1987 Jan 01; 25(4). PMID: 3118049
Highly Cited.
Regression of devil facial tumour disease following immunotherapy in immunised Tasmanian devils.
Cesar Tovar, Ruth J Pye, +16 authors, Gregory M Woods.
Sci Rep, 2017 Mar 10; 7. PMID: 28276463    Free PMC article.
Anti-CD47 antibody synergizes with rituximab to promote phagocytosis and eradicate non-Hodgkin lymphoma.
Mark P Chao, Ash A Alizadeh, +17 authors, Ravindra Majeti.
Cell, 2010 Sep 04; 142(5). PMID: 20813259    Free PMC article.
Highly Cited.
De novo transcript sequence reconstruction from RNA-seq using the Trinity platform for reference generation and analysis.
Brian J Haas, Alexie Papanicolaou, +20 authors, Aviv Regev.
Nat Protoc, 2013 Jul 13; 8(8). PMID: 23845962    Free PMC article.
Highly Cited.
LGALS3 as a prognostic factor for classical Hodgkin's lymphoma.
Young Wha Koh, Se Jin Jung, +3 authors, Jooryung Huh.
Mod Pathol, 2014 Mar 08; 27(10). PMID: 24603587
Full-length transcriptome assembly from RNA-Seq data without a reference genome.
Manfred G Grabherr, Brian J Haas, +18 authors, Aviv Regev.
Nat Biotechnol, 2011 May 17; 29(7). PMID: 21572440    Free PMC article.
Highly Cited.
Role of 4-1BB in allograft rejection mediated by CD8+ T cells.
Jun Wang, Zhong Guo, +6 authors, Kenneth A Newell.
Am J Transplant, 2003 May 20; 3(5). PMID: 12752310
Expression of a CD200 transgene is necessary for induction but not maintenance of tolerance to cardiac and skin allografts.
Reginald M Gorczynski, Zhiqi Chen, +4 authors, Ivo Boudakov.
J Immunol, 2009 Jul 14; 183(3). PMID: 19592654
Higher bone marrow LGALS3 expression is an independent unfavorable prognostic factor for overall survival in patients with acute myeloid leukemia.
Chieh-Lung Cheng, Hsin-An Hou, +15 authors, Hwei-Fang Tien.
Blood, 2013 Mar 02; 121(16). PMID: 23449638
CD137 stimulation delivers an antigen-independent growth signal for T lymphocytes with memory phenotype.
Yuwen Zhu, Gefeng Zhu, +2 authors, Lieping Chen.
Blood, 2007 Jan 25; 109(11). PMID: 17244673    Free PMC article.
Cutting edge: A monoclonal antibody specific for the programmed death-1 homolog prevents graft-versus-host disease in mouse models.
Dallas B Flies, Shengdian Wang, Haiying Xu, Lieping Chen.
J Immunol, 2011 Jul 20; 187(4). PMID: 21768399    Free PMC article.
Galectin-3 Shapes Antitumor Immune Responses by Suppressing CD8+ T Cells via LAG-3 and Inhibiting Expansion of Plasmacytoid Dendritic Cells.
Theodore Kouo, Lanqing Huang, +4 authors, Elizabeth Jaffee.
Cancer Immunol Res, 2015 Feb 19; 3(4). PMID: 25691328    Free PMC article.
Highly Cited.
Demonstration of immune responses against devil facial tumour disease in wild Tasmanian devils.
Ruth Pye, Rodrigo Hamede, +7 authors, Gregory M Woods.
Biol Lett, 2017 Jan 26; 12(10). PMID: 28120799    Free PMC article.
Targeting Tim-3 and PD-1 pathways to reverse T cell exhaustion and restore anti-tumor immunity.
Kaori Sakuishi, Lionel Apetoh, +3 authors, Ana C Anderson.
J Exp Med, 2010 Sep 08; 207(10). PMID: 20819927    Free PMC article.
Highly Cited.
Advantages of combined transmembrane topology and signal peptide prediction--the Phobius web server.
Lukas Käll, Anders Krogh, Erik L L Sonnhammer.
Nucleic Acids Res, 2007 May 08; 35(Web Server issue). PMID: 17483518    Free PMC article.
Highly Cited.
PD-1 inhibits T-cell receptor induced phosphorylation of the ZAP70/CD3zeta signalosome and downstream signaling to PKCtheta.
Kelly-Ann Sheppard, Lori J Fitz, +8 authors, Divya Chaudhary.
FEBS Lett, 2004 Sep 11; 574(1-3). PMID: 15358536
Highly Cited.
Molecular cloning of a CD28 cDNA by a high-efficiency COS cell expression system.
A Aruffo, B Seed.
Proc Natl Acad Sci U S A, 1987 Dec 01; 84(23). PMID: 2825196    Free PMC article.
Highly Cited.
Inhibitory receptors on lymphocytes: insights from infections.
Pamela M Odorizzi, E John Wherry.
J Immunol, 2012 Mar 24; 188(7). PMID: 22442493    Free PMC article.
Review.
Competition between TRAF2 and TRAF6 regulates NF-kappaB activation in human B lymphocytes.
Wen Zhang, Xuan Zhang, +4 authors, Peter E Lipsky.
Chin Med Sci J, 2010 May 11; 25(1). PMID: 20449947
Ectopic expression of murine CD47 minimizes macrophage rejection of human hepatocyte xenografts in immunodeficient mice.
Johan M Waern, Qinggong Yuan, +11 authors, Michael Bock.
Hepatology, 2012 Apr 27; 56(4). PMID: 22535707
Mitogen-activated Tasmanian devil blood mononuclear cells kill devil facial tumour disease cells.
Gabriella K Brown, Cesar Tovar, +7 authors, Gregory M Woods.
Immunol Cell Biol, 2016 Apr 20; 94(7). PMID: 27089941
The TNF Receptor Superfamily in Co-stimulating and Co-inhibitory Responses.
Lindsay K Ward-Kavanagh, Wai Wai Lin, John R Šedý, Carl F Ware.
Immunity, 2016 May 19; 44(5). PMID: 27192566    Free PMC article.
Highly Cited. Review.
Emerging roles of p53 and other tumour-suppressor genes in immune regulation.
César Muñoz-Fontela, Anna Mandinova, Stuart A Aaronson, Sam W Lee.
Nat Rev Immunol, 2016 Nov 01; 16(12). PMID: 27667712    Free PMC article.
Highly Cited. Review.
A second transmissible cancer in Tasmanian devils.
Ruth J Pye, David Pemberton, +12 authors, Gregory M Woods.
Proc Natl Acad Sci U S A, 2015 Dec 30; 113(2). PMID: 26711993    Free PMC article.
Highly Cited.
TIM-1 and TIM-4 glycoproteins bind phosphatidylserine and mediate uptake of apoptotic cells.
Norimoto Kobayashi, Piia Karisola, +15 authors, Gordon J Freeman.
Immunity, 2007 Dec 18; 27(6). PMID: 18082433    Free PMC article.
Highly Cited.
Lag-3, Tim-3, and TIGIT: Co-inhibitory Receptors with Specialized Functions in Immune Regulation.
Ana C Anderson, Nicole Joller, Vijay K Kuchroo.
Immunity, 2016 May 19; 44(5). PMID: 27192565    Free PMC article.
Highly Cited. Review.
Inducible T cell antigen 4-1BB. Analysis of expression and function.
K E Pollok, Y J Kim, +4 authors, B S Kwon.
J Immunol, 1993 Feb 01; 150(3). PMID: 7678621
Highly Cited.
Interaction of human PD-L1 and B7-1.
Manish J Butte, Victor Peña-Cruz, +2 authors, Arlene H Sharpe.
Mol Immunol, 2008 Jul 01; 45(13). PMID: 18585785    Free PMC article.
A chicken homologue of the co-stimulating molecule CD80 which binds to mammalian CTLA-4.
M N O'Regan, K R Parsons, C A Tregaskes, J R Young.
Immunogenetics, 1998 Nov 13; 49(1). PMID: 9811970
Genomic organization and expression analysis of B7-H4, an immune inhibitory molecule of the B7 family.
In-Hak Choi, Gefeng Zhu, +7 authors, Lieping Chen.
J Immunol, 2003 Oct 22; 171(9). PMID: 14568939
The TRAF6, but not the TRAF2/3, binding domain of CD40 is required for cytokine production in human lung fibroblasts.
Jeffrey M Purkerson, Roger S Smith, Stephen J Pollock, Richard P Phipps.
Eur J Immunol, 2005 Sep 07; 35(10). PMID: 16143987
Tim-3 fosters HCC development by enhancing TGF-β-mediated alternative activation of macrophages.
Wenjiang Yan, Xiao Liu, +5 authors, Chunhong Ma.
Gut, 2015 Jan 23; 64(10). PMID: 25608525
Highly Cited.
Increase of cells expressing PD-L1 in bovine leukemia virus infection and enhancement of anti-viral immune responses in vitro via PD-L1 blockade.
Ryoyo Ikebuchi, Satoru Konnai, +4 authors, Kazuhiko Ohashi.
Vet Res, 2011 Sep 29; 42. PMID: 21943148    Free PMC article.
CD200 in CNS tumor-induced immunosuppression: the role for CD200 pathway blockade in targeted immunotherapy.
Christopher L Moertel, Junzhe Xia, +9 authors, Michael R Olin.
J Immunother Cancer, 2015 Jan 20; 2(1). PMID: 25598973    Free PMC article.
Molecular mechanisms of T cell co-stimulation and co-inhibition.
Lieping Chen, Dallas B Flies.
Nat Rev Immunol, 2013 Mar 09; 13(4). PMID: 23470321    Free PMC article.
Highly Cited. Review.
Tumor cell programmed death ligand 1-mediated T cell suppression is overcome by coexpression of CD80.
Samuel T Haile, Jacobus J Bosch, +7 authors, Suzanne Ostrand-Rosenberg.
J Immunol, 2011 May 11; 186(12). PMID: 21555531    Free PMC article.
Genetic diversity and population structure of the endangered marsupial Sarcophilus harrisii (Tasmanian devil).
Webb Miller, Vanessa M Hayes, +27 authors, Stephan C Schuster.
Proc Natl Acad Sci U S A, 2011 Jun 29; 108(30). PMID: 21709235    Free PMC article.
The costimulatory molecule B7-H4 promote tumor progression and cell proliferation through translocating into nucleus.
L Zhang, H Wu, +12 authors, X Zhang.
Oncogene, 2013 Jan 16; 32(46). PMID: 23318460    Free PMC article.
Basic local alignment search tool.
S F Altschul, W Gish, +2 authors, D J Lipman.
J Mol Biol, 1990 Oct 05; 215(3). PMID: 2231712
Highly Cited.
Identification of c-erbB-3 binding sites for phosphatidylinositol 3'-kinase and SHC using an EGF receptor/c-erbB-3 chimera.
S A Prigent, W J Gullick.
EMBO J, 1994 Jun 15; 13(12). PMID: 8026468    Free PMC article.
Highly Cited.
Cell surface galectin-9 expressing Th cells regulate Th17 and Foxp3+ Treg development by galectin-9 secretion.
Souichi Oomizu, Tomohiro Arikawa, +7 authors, Mitsuomi Hirashima.
PLoS One, 2012 Nov 13; 7(11). PMID: 23144904    Free PMC article.
Breast cancer cell CD200 expression regulates immune response to EMT6 tumor cells in mice.
Reginald M Gorczynski, Zhiqi Chen, +4 authors, Julia Behnke.
Breast Cancer Res Treat, 2009 Dec 03; 123(2). PMID: 19953316
Reduced galectin-3 expression is an indicator of unfavorable prognosis in gastric cancer.
Kohji Okada, Tatsuo Shimura, +2 authors, Hiroyuki Kuwano.
Anticancer Res, 2006 Apr 20; 26(2B). PMID: 16619546
Promotion of tissue inflammation by the immune receptor Tim-3 expressed on innate immune cells.
Ana C Anderson, David E Anderson, +11 authors, David A Hafler.
Science, 2007 Nov 17; 318(5853). PMID: 18006747
Highly Cited.
Porcine CTLA4-Ig lacks a MYPPPY motif, binds inefficiently to human B7 and specifically suppresses human CD4+ T cell responses costimulated by pig but not human B7.
A N Vaughan, P Malde, +3 authors, A Dorling.
J Immunol, 2000 Sep 07; 165(6). PMID: 10975832
The Tasmanian devil transcriptome reveals Schwann cell origins of a clonally transmissible cancer.
Elizabeth P Murchison, Cesar Tovar, +16 authors, Anthony T Papenfuss.
Science, 2010 Jan 02; 327(5961). PMID: 20044575    Free PMC article.
Human CD47 expression permits survival of porcine cells in immunodeficient mice that express SIRPα capable of binding to human CD47.
Chunfeng Wang, Hui Wang, +4 authors, Yong-Guang Yang.
Cell Transplant, 2011 May 04; 20(11-12). PMID: 21535911    Free PMC article.
Toll-like receptor signaling is functional in immune cells of the endangered Tasmanian devil.
Amanda L Patchett, Roger Latham, +3 authors, Gregory M Woods.
Dev Comp Immunol, 2015 Jul 18; 53(1). PMID: 26182986
Dynamic Treg interactions with intratumoral APCs promote local CTL dysfunction.
Christian A Bauer, Edward Y Kim, +3 authors, Thorsten R Mempel.
J Clin Invest, 2014 May 09; 124(6). PMID: 24812664    Free PMC article.
Highly Cited.
B7-H4, a molecule of the B7 family, negatively regulates T cell immunity.
Gabriel L Sica, In Hak Choi, +7 authors, Lieping Chen.
Immunity, 2003 Jun 24; 18(6). PMID: 12818165
Highly Cited.
OX40 engagement depletes intratumoral Tregs via activating FcγRs, leading to antitumor efficacy.
Yannick Bulliard, Rose Jolicoeur, +3 authors, Jennifer L Brogdon.
Immunol Cell Biol, 2014 Apr 16; 92(6). PMID: 24732076
Highly Cited.
Functional CD47/signal regulatory protein alpha (SIRP(alpha)) interaction is required for optimal human T- and natural killer- (NK) cell homeostasis in vivo.
Nicolas Legrand, Nicholas D Huntington, +10 authors, Hergen Spits.
Proc Natl Acad Sci U S A, 2011 Jul 27; 108(32). PMID: 21788504    Free PMC article.
Crystal structure of the B7-1/CTLA-4 complex that inhibits human immune responses.
C C Stamper, Y Zhang, +7 authors, L Mosyak.
Nature, 2001 Mar 30; 410(6828). PMID: 11279502
Highly Cited.
B7-H1 is a ubiquitous antiapoptotic receptor on cancer cells.
Takeshi Azuma, Sheng Yao, +3 authors, Lieping Chen.
Blood, 2008 Jan 29; 111(7). PMID: 18223165    Free PMC article.
Highly Cited.
A new member of the immunoglobulin superfamily--CTLA-4.
J F Brunet, F Denizot, +4 authors, P Golstein.
Nature, 1987 Jul 16; 328(6127). PMID: 3496540
Highly Cited.
Genome sequencing and analysis of the Tasmanian devil and its transmissible cancer.
Elizabeth P Murchison, Ole B Schulz-Trieglaff, +53 authors, Michael R Stratton.
Cell, 2012 Feb 22; 148(4). PMID: 22341448    Free PMC article.
Highly Cited.
Utility of CD200 immunostaining in the diagnosis of primary mediastinal large B cell lymphoma: comparison with MAL, CD23, and other markers.
David M Dorfman, Aliakbar Shahsafaei, Miguel A Alonso.
Mod Pathol, 2012 Aug 18; 25(12). PMID: 22899296
Genomic restructuring in the Tasmanian devil facial tumour: chromosome painting and gene mapping provide clues to evolution of a transmissible tumour.
Janine E Deakin, Hannah S Bender, +12 authors, Jennifer A Marshall Graves.
PLoS Genet, 2012 Feb 24; 8(2). PMID: 22359511    Free PMC article.
In search of the 'missing self': MHC molecules and NK cell recognition.
H G Ljunggren, K Kärre.
Immunol Today, 1990 Jul 01; 11(7). PMID: 2201309
Highly Cited. Review.
A comparative overview of immunoglobulin genes and the generation of their diversity in tetrapods.
Yi Sun, Zhiguo Wei, Ning Li, Yaofeng Zhao.
Dev Comp Immunol, 2012 Mar 01; 39(1-2). PMID: 22366185
Review.
Allograft theory: transmission of devil facial-tumour disease.
A-M Pearse, K Swift.
Nature, 2006 Feb 03; 439(7076). PMID: 16452970
Highly Cited.
LAG-3, TGF-β, and cell-intrinsic PD-1 inhibitory pathways contribute to CD8 but not CD4 T-cell tolerance induced by allogeneic BMT with anti-CD40L.
Carrie L Lucas, Creg J Workman, +4 authors, Megan Sykes.
Blood, 2011 Mar 23; 117(20). PMID: 21422469    Free PMC article.
T cell/transmembrane, Ig, and mucin-3 allelic variants differentially recognize phosphatidylserine and mediate phagocytosis of apoptotic cells.
Rosemarie H DeKruyff, Xia Bu, +9 authors, José M Casasnovas.
J Immunol, 2010 Jan 20; 184(4). PMID: 20083673    Free PMC article.
Highly Cited.
Maturation and activation of dendritic cells induced by lymphocyte activation gene-3 (CD223).
Susanne Andreae, Fabienne Piras, Nicolas Burdin, Frédéric Triebel.
J Immunol, 2002 Apr 09; 168(8). PMID: 11937541
Natural killer cell mediated cytotoxic responses in the Tasmanian devil.
Gabriella K Brown, Alexandre Kreiss, A Bruce Lyons, Gregory M Woods.
PLoS One, 2011 Oct 01; 6(9). PMID: 21957452    Free PMC article.
CTLA-4 and CD28: similar proteins, neighbouring genes.
C Balzano, N Buonavista, E Rouvier, P Golstein.
Int J Cancer Suppl, 1992 Jan 01; 7. PMID: 1330947
Review.
High level of soluble programmed cell death ligand 1 in blood impacts overall survival in aggressive diffuse large B-Cell lymphoma: results from a French multicenter clinical trial.
D Rossille, M Gressier, +11 authors, Groupe Ouest-Est des Leucémies et Autres Maladies du Sang.
Leukemia, 2014 Apr 16; 28(12). PMID: 24732592
Highly Cited.
VISTA, a novel mouse Ig superfamily ligand that negatively regulates T cell responses.
Li Wang, Rotem Rubinstein, +10 authors, Randolph J Noelle.
J Exp Med, 2011 Mar 09; 208(3). PMID: 21383057    Free PMC article.
Highly Cited.
Trans-endocytosis of CD80 and CD86: a molecular basis for the cell-extrinsic function of CTLA-4.
Omar S Qureshi, Yong Zheng, +12 authors, David M Sansom.
Science, 2011 Apr 09; 332(6029). PMID: 21474713    Free PMC article.
Highly Cited.
The eukaryotic linear motif resource ELM: 10 years and counting.
Holger Dinkel, Kim Van Roey, +17 authors, Toby J Gibson.
Nucleic Acids Res, 2013 Nov 12; 42(Database issue). PMID: 24214962    Free PMC article.
Highly Cited.
Soluble CD80 restores T cell activation and overcomes tumor cell programmed death ligand 1-mediated immune suppression.
Samuel T Haile, Sonia P Dalal, +2 authors, Suzanne Ostrand-Rosenberg.
J Immunol, 2013 Aug 07; 191(5). PMID: 23918985    Free PMC article.
VISTA Regulates the Development of Protective Antitumor Immunity.
Isabelle Le Mercier, Wenna Chen, +5 authors, Li Wang.
Cancer Res, 2014 Apr 03; 74(7). PMID: 24691994    Free PMC article.
Highly Cited.
The Tim-3 ligand galectin-9 negatively regulates T helper type 1 immunity.
Chen Zhu, Ana C Anderson, +6 authors, Vijay K Kuchroo.
Nat Immunol, 2005 Nov 16; 6(12). PMID: 16286920
Highly Cited.
Cattle CTLA-4, CD28 and chicken CD28 bind CD86: MYPPPY is not conserved in cattle CD28.
K R Parsons, J R Young, B A Collins, C J Howard.
Immunogenetics, 1996 Jan 01; 43(6). PMID: 8606060
Programmed death 1-mediated T cell exhaustion during visceral leishmaniasis impairs phagocyte function.
Kevin J Esch, Rachel Juelsgaard, +2 authors, Christine A Petersen.
J Immunol, 2013 Oct 25; 191(11). PMID: 24154626    Free PMC article.
Evidence that an OX-2-positive cell can inhibit the stimulation of type 1 cytokine production by bone marrow-derived B7-1 (and B7-2)-positive dendritic cells.
L Gorczynski, Z Chen, +4 authors, R M Gorczynski.
J Immunol, 1999 Jan 23; 162(2). PMID: 9916698
PD-L1 Is Not Constitutively Expressed on Tasmanian Devil Facial Tumor Cells but Is Strongly Upregulated in Response to IFN-γ and Can Be Expressed in the Tumor Microenvironment.
Andrew S Flies, A Bruce Lyons, +5 authors, John D Hayball.
Front Immunol, 2016 Dec 27; 7. PMID: 28018348    Free PMC article.
An ovarian tumor marker with homology to vaccinia virus contains an IgV-like region and multiple transmembrane domains.
I G Campbell, P S Freemont, W Foulkes, J Trowsdale.
Cancer Res, 1992 Oct 01; 52(19). PMID: 1394148
ExPASy: The proteomics server for in-depth protein knowledge and analysis.
Elisabeth Gasteiger, Alexandre Gattiker, +3 authors, Amos Bairoch.
Nucleic Acids Res, 2003 Jun 26; 31(13). PMID: 12824418    Free PMC article.
Highly Cited.
Immune-checkpoint proteins VISTA and PD-1 nonredundantly regulate murine T-cell responses.
Jun Liu, Ying Yuan, +8 authors, Li Wang.
Proc Natl Acad Sci U S A, 2015 May 13; 112(21). PMID: 25964334    Free PMC article.
Highly Cited.
Radiation and dual checkpoint blockade activate non-redundant immune mechanisms in cancer.
Christina Twyman-Saint Victor, Andrew J Rech, +22 authors, Andy J Minn.
Nature, 2015 Mar 11; 520(7547). PMID: 25754329    Free PMC article.
Highly Cited.
Attenuation of phagocytosis of xenogeneic cells by manipulating CD47.
Hui Wang, Jon VerHalen, +6 authors, Yong-Guang Yang.
Blood, 2006 Sep 30; 109(2). PMID: 17008545    Free PMC article.
B7S1, a novel B7 family member that negatively regulates T cell activation.
Durbaka V R Prasad, Sabrina Richards, Xoi Muoi Mai, Chen Dong.
Immunity, 2003 Jun 24; 18(6). PMID: 12818166
Highly Cited.
Structural basis for co-stimulation by the human CTLA-4/B7-2 complex.
J C Schwartz, X Zhang, +2 authors, S C Almo.
Nature, 2001 Mar 30; 410(6828). PMID: 11279501
Widespread transmission of independent cancer lineages within multiple bivalve species.
Michael J Metzger, Antonio Villalba, +6 authors, Stephen P Goff.
Nature, 2016 Jun 25; 534(7609). PMID: 27338791    Free PMC article.
Highly Cited.
The MHC class II ligand lymphocyte activation gene-3 is co-distributed with CD8 and CD3-TCR molecules after their engagement by mAb or peptide-MHC class I complexes.
S Hannier, F Triebel.
Int Immunol, 1999 Nov 05; 11(11). PMID: 10545478
NK cell triggering by the human costimulatory molecules CD80 and CD86.
J L Wilson, J Charo, +6 authors, H G Ljunggren.
J Immunol, 1999 Oct 08; 163(8). PMID: 10510357
The interaction between signal regulatory protein alpha (SIRPα) and CD47: structure, function, and therapeutic target.
A Neil Barclay, Timo K Van den Berg.
Annu Rev Immunol, 2013 Nov 13; 32. PMID: 24215318
Highly Cited. Review.
Immune inhibitory molecules LAG-3 and PD-1 synergistically regulate T-cell function to promote tumoral immune escape.
Seng-Ryong Woo, Meghan E Turnis, +18 authors, Dario A A Vignali.
Cancer Res, 2011 Dec 22; 72(4). PMID: 22186141    Free PMC article.
Highly Cited.
Primary breast cancer: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up.
E Senkus, S Kyriakides, +6 authors, ESMO Guidelines Committee.
Ann Oncol, 2015 Sep 01; 26 Suppl 5. PMID: 26314782
Highly Cited.
T cell immunoglobulin mucin-3 crystal structure reveals a galectin-9-independent ligand-binding surface.
Erhu Cao, Xingxing Zang, +12 authors, Steven C Almo.
Immunity, 2007 Mar 17; 26(3). PMID: 17363302
Blockade of 4-1BB (CD137)/4-1BB ligand interactions increases allograft survival.
H R Cho, B Kwon, +12 authors, B S Kwon.
Transpl Int, 2004 Sep 07; 17(7). PMID: 15349720
CD150 association with either the SH2-containing inositol phosphatase or the SH2-containing protein tyrosine phosphatase is regulated by the adaptor protein SH2D1A.
L M Shlapatska, S V Mikhalap, +5 authors, S P Sidorenko.
J Immunol, 2001 Apr 21; 166(9). PMID: 11313386
Anti-CD47 antibody-mediated phagocytosis of cancer by macrophages primes an effective antitumor T-cell response.
Diane Tseng, Jens-Peter Volkmer, +8 authors, Irving L Weissman.
Proc Natl Acad Sci U S A, 2013 May 22; 110(27). PMID: 23690610    Free PMC article.
Highly Cited.
CD47 fusion protein targets CD172a+ cells in Crohn's disease and dampens the production of IL-1β and TNF.
Nobuyasu Baba, Vu Quang Van, +25 authors, Marika Sarfati.
J Exp Med, 2013 May 15; 210(6). PMID: 23669395    Free PMC article.
MYC regulates the antitumor immune response through CD47 and PD-L1.
Stephanie C Casey, Ling Tong, +8 authors, Dean W Felsher.
Science, 2016 Mar 12; 352(6282). PMID: 26966191    Free PMC article.
Highly Cited.
Upregulation of Tim-3 and PD-1 expression is associated with tumor antigen-specific CD8+ T cell dysfunction in melanoma patients.
Julien Fourcade, Zhaojun Sun, +6 authors, Hassane M Zarour.
J Exp Med, 2010 Sep 08; 207(10). PMID: 20819923    Free PMC article.
Highly Cited.
Novel T cell antigen 4-1BB associates with the protein tyrosine kinase p56lck1.
Y J Kim, K E Pollok, +4 authors, B S Kwon.
J Immunol, 1993 Aug 01; 151(3). PMID: 8335927
Control of signaling-mediated clearance of apoptotic cells by the tumor suppressor p53.
Kyoung Wan Yoon, Sanguine Byun, +13 authors, Sam W Lee.
Science, 2015 Aug 01; 349(6247). PMID: 26228159    Free PMC article.
Highly Cited.
Coinhibitory receptor PD-1H preferentially suppresses CD4⁺ T cell-mediated immunity.
Dallas B Flies, Xue Han, +4 authors, Lieping Chen.
J Clin Invest, 2014 Apr 20; 124(5). PMID: 24743150    Free PMC article.
Highly Cited.
Tim protein structures reveal a unique face for ligand binding.
Ana C Anderson, Sheng Xiao, Vijay K Kuchroo.
Immunity, 2007 Mar 23; 26(3). PMID: 17376389
MHC class II signal transduction in human dendritic cells induced by a natural ligand, the LAG-3 protein (CD223).
Susanne Andreae, Sandrine Buisson, Frédéric Triebel.
Blood, 2003 May 31; 102(6). PMID: 12775570
Human Soluble CD80 is generated by alternative splicing, and recombinant soluble CD80 binds to CD28 and CD152 influencing T-cell activation.
M Kakoulidou, R Giscombe, +2 authors, X Wang.
Scand J Immunol, 2007 Oct 24; 66(5). PMID: 17953528
Horizontal transmission of clonal cancer cells causes leukemia in soft-shell clams.
Michael J Metzger, Carol Reinisch, James Sherry, Stephen P Goff.
Cell, 2015 Apr 11; 161(2). PMID: 25860608    Free PMC article.
Highly Cited.
Cancer stem cells, CD200 and immunoevasion.
Brian T Kawasaki, William L Farrar.
Trends Immunol, 2008 Sep 09; 29(10). PMID: 18775673
Coinhibitory Pathways in the B7-CD28 Ligand-Receptor Family.
Frank A Schildberg, Sarah R Klein, Gordon J Freeman, Arlene H Sharpe.
Immunity, 2016 May 19; 44(5). PMID: 27192563    Free PMC article.
Highly Cited. Review.
Molecular cloning and sequencing of canine T-cell costimulatory molecule (CD28).
T S Khatlani, Z Ma, M Okuda, T Onishi.
Vet Immunol Immunopathol, 2001 Apr 09; 78(3-4). PMID: 11292534
Calreticulin is the dominant pro-phagocytic signal on multiple human cancers and is counterbalanced by CD47.
Mark P Chao, Siddhartha Jaiswal, +9 authors, Irving L Weissman.
Sci Transl Med, 2010 Dec 24; 2(63). PMID: 21178137    Free PMC article.
Highly Cited.
Natural Killer Cell Functional Activity After 4-1BB Costimulation.
Shadi sadat Navabi, Mehrnoosh Doroudchi, Ahmad Hosseini Tashnizi, Mojtaba Habibagahi.
Inflammation, 2014 Dec 19; 38(3). PMID: 25520217
Blockade of bovine PD-1 increases T cell function and inhibits bovine leukemia virus expression in B cells in vitro.
Ryoyo Ikebuchi, Satoru Konnai, +5 authors, Kazuhiko Ohashi.
Vet Res, 2013 Jul 24; 44. PMID: 23876077    Free PMC article.
The B7 family of immunoregulatory receptors: a comparative and evolutionary perspective.
John D Hansen, Louis Du Pasquier, +3 authors, Pierre Boudinot.
Mol Immunol, 2008 Dec 17; 46(3). PMID: 19081138
Combined Nivolumab and Ipilimumab or Monotherapy in Untreated Melanoma.
James Larkin, Vanna Chiarion-Sileni, +28 authors, Jedd D Wolchok.
N Engl J Med, 2015 Jun 02; 373(1). PMID: 26027431    Free PMC article.
Highly Cited.
Increased CD200 expression in acute myeloid leukemia is linked with an increased frequency of FoxP3+ regulatory T cells.
S J Coles, R K Hills, +4 authors, A Tonks.
Leukemia, 2012 Mar 21; 26(9). PMID: 22430636    Free PMC article.
Cooperation of PD-1 and LAG-3 Contributes to T-Cell Exhaustion in Anaplasma marginale-Infected Cattle.
Tomohiro Okagawa, Satoru Konnai, +5 authors, Wendy C Brown.
Infect Immun, 2016 Jul 20; 84(10). PMID: 27430272    Free PMC article.
Co-expression of the toleragenic glycoprotein, CD200, with markers for cancer stem cells.
Brian T Kawasaki, Tashan Mistree, +2 authors, William L Farrar.
Biochem Biophys Res Commun, 2007 Oct 30; 364(4). PMID: 17964286    Free PMC article.
Phase III randomized clinical trial comparing tremelimumab with standard-of-care chemotherapy in patients with advanced melanoma.
Antoni Ribas, Richard Kefford, +21 authors, Axel Hauschild.
J Clin Oncol, 2013 Jan 09; 31(5). PMID: 23295794    Free PMC article.
Highly Cited.
New insights into cancer immunoediting and its three component phases--elimination, equilibrium and escape.
Deepak Mittal, Matthew M Gubin, Robert D Schreiber, Mark J Smyth.
Curr Opin Immunol, 2014 Feb 18; 27. PMID: 24531241    Free PMC article.
Highly Cited. Review.
SHP-1 and SHP-2 associate with immunoreceptor tyrosine-based switch motif of programmed death 1 upon primary human T cell stimulation, but only receptor ligation prevents T cell activation.
Jens M Chemnitz, Richard V Parry, +2 authors, James L Riley.
J Immunol, 2004 Jul 09; 173(2). PMID: 15240681
Highly Cited.
Increased expression of the LGALS3 (galectin 3) gene in human non-small-cell lung cancer.
Akinobu Yoshimura, Akihiko Gemma, +12 authors, Shoji Kudoh.
Genes Chromosomes Cancer, 2003 Apr 16; 37(2). PMID: 12696064
Costimulatory receptors in jawed vertebrates: conserved CD28, odd CTLA4 and multiple BTLAs.
David Bernard, John D Hansen, +3 authors, Pierre Boudinot.
Dev Comp Immunol, 2006 Aug 25; 31(3). PMID: 16928399
Integrin-associated protein: a 50-kD plasma membrane antigen physically and functionally associated with integrins.
E Brown, L Hooper, T Ho, H Gresham.
J Cell Biol, 1990 Dec 01; 111(6 Pt 1). PMID: 2277087    Free PMC article.
Highly Cited.
Phylogenetic divergence of CD47 interactions with human signal regulatory protein alpha reveals locus of species specificity. Implications for the binding site.
Shyamsundar Subramanian, Eric T Boder, Dennis E Discher.
J Biol Chem, 2006 Nov 14; 282(3). PMID: 17098740
The contextual role of TNFR family members in CD8(+) T-cell control of viral infections.
Michael E Wortzman, Derek L Clouthier, +2 authors, Tania H Watts.
Immunol Rev, 2013 Aug 21; 255(1). PMID: 23947352
Review.
Reversible epigenetic down-regulation of MHC molecules by devil facial tumour disease illustrates immune escape by a contagious cancer.
Hannah V Siddle, Alexandre Kreiss, +10 authors, Jim Kaufman.
Proc Natl Acad Sci U S A, 2013 Mar 13; 110(13). PMID: 23479617    Free PMC article.
Highly Cited.
LAG-3 regulates CD8+ T cell accumulation and effector function in murine self- and tumor-tolerance systems.
Joseph F Grosso, Cristin C Kelleher, +10 authors, Charles G Drake.
J Clin Invest, 2007 Oct 13; 117(11). PMID: 17932562    Free PMC article.
Highly Cited.
CD137 ligand mediates opposite effects in human and mouse NK cells and impairs NK-cell reactivity against human acute myeloid leukemia cells.
Tina Baessler, Jean Enno Charton, +5 authors, Helmut Rainer Salih.
Blood, 2009 Dec 17; 115(15). PMID: 20008791
Role for CD47-SIRPalpha signaling in xenograft rejection by macrophages.
Kentaro Ide, Hui Wang, +6 authors, Hideki Ohdan.
Proc Natl Acad Sci U S A, 2007 Mar 16; 104(12). PMID: 17360380    Free PMC article.
Feline programmed death and its ligand: characterization and changes with feline immunodeficiency virus infection.
A Folkl, X Wen, +2 authors, D Bienzle.
Vet Immunol Immunopathol, 2009 Nov 26; 134(1-2). PMID: 19931185
UniProt: a hub for protein information.
UniProt Consortium.
Nucleic Acids Res, 2014 Oct 29; 43(Database issue). PMID: 25348405    Free PMC article.
Highly Cited.
LAG-3, a novel lymphocyte activation gene closely related to CD4.
F Triebel, S Jitsukawa, +4 authors, T Hercend.
J Exp Med, 1990 May 01; 171(5). PMID: 1692078    Free PMC article.
Highly Cited.
Coexpression of Tim-3 and PD-1 identifies a CD8+ T-cell exhaustion phenotype in mice with disseminated acute myelogenous leukemia.
Qing Zhou, Meghan E Munger, +8 authors, Bruce R Blazar.
Blood, 2011 Mar 10; 117(17). PMID: 21385853    Free PMC article.
Highly Cited.
Systematic identification of cell cycle-dependent yeast nucleocytoplasmic shuttling proteins by prediction of composite motifs.
Shunichi Kosugi, Masako Hasebe, Masaru Tomita, Hiroshi Yanagawa.
Proc Natl Acad Sci U S A, 2009 Jun 13; 106(25). PMID: 19520826    Free PMC article.
Highly Cited.
Functionally distinct LAG-3 and PD-1 subsets on activated and chronically stimulated CD8 T cells.
Joseph F Grosso, Monica V Goldberg, +7 authors, Charles G Drake.
J Immunol, 2009 May 21; 182(11). PMID: 19454660    Free PMC article.
Fc-dependent depletion of tumor-infiltrating regulatory T cells co-defines the efficacy of anti-CTLA-4 therapy against melanoma.
Tyler R Simpson, Fubin Li, +11 authors, Sergio A Quezada.
J Exp Med, 2013 Jul 31; 210(9). PMID: 23897981    Free PMC article.
Highly Cited.
4-1BB and Ox40 are members of a tumor necrosis factor (TNF)-nerve growth factor receptor subfamily that bind TNF receptor-associated factors and activate nuclear factor kappaB.
R H Arch, C B Thompson.
Mol Cell Biol, 1998 Jan 07; 18(1). PMID: 9418902    Free PMC article.
RGMb is a novel binding partner for PD-L2 and its engagement with PD-L2 promotes respiratory tolerance.
Yanping Xiao, Sanhong Yu, +9 authors, Gordon J Freeman.
J Exp Med, 2014 Apr 23; 211(5). PMID: 24752301    Free PMC article.
Highly Cited.
Cutting edge: induction of B7-H4 on APCs through IL-10: novel suppressive mode for regulatory T cells.
Ilona Kryczek, Shuang Wei, +5 authors, Weiping Zou.
J Immunol, 2006 Jun 21; 177(1). PMID: 16785496
B7-DC, a new dendritic cell molecule with potent costimulatory properties for T cells.
S Y Tseng, M Otsuji, +7 authors, H Tsuchiya.
J Exp Med, 2001 Apr 03; 193(7). PMID: 11283156    Free PMC article.
Highly Cited.
Expression of CD200 on AML blasts directly suppresses memory T-cell function.
S J Coles, R K Hills, +4 authors, A Tonks.
Leukemia, 2012 Mar 21; 26(9). PMID: 22430635    Free PMC article.
Apoptotic PS to phagocyte TIM-4: eat me.
John Savill, Chris Gregory.
Immunity, 2007 Dec 21; 27(6). PMID: 18093535
Human herpesvirus 8 K14 protein mimics CD200 in down-regulating macrophage activation through CD200 receptor.
Mildred Foster-Cuevas, Gavin J Wright, +2 authors, A Neil Barclay.
J Virol, 2004 Jun 29; 78(14). PMID: 15220441    Free PMC article.
Detection of Signal Regulatory Protein α in Saimiri sciureus (Squirrel Monkey) by Anti-Human Monoclonal Antibody.
Hugo Amorim Dos Santos de Souza, Edmar Henrique Costa-Correa, +5 authors, Paulo Renato Rivas Totino.
Front Immunol, 2018 Jan 10; 8. PMID: 29312325    Free PMC article.
Gene array analysis of PD-1H overexpressing monocytes reveals a pro-inflammatory profile.
Preeti Bharaj, Chunting Ye, +5 authors, Guohua Yi.
Heliyon, 2018 Mar 13; 4(2). PMID: 29527580    Free PMC article.
Two Decades of the Impact of Tasmanian Devil Facial Tumor Disease.
Gregory M Woods, Samantha Fox, +6 authors, Silvana S Bettiol.
Integr Comp Biol, 2018 Sep 27; 58(6). PMID: 30252058    Free PMC article.
A novel system to map protein interactions reveals evolutionarily conserved immune evasion pathways on transmissible cancers.
Andrew S Flies, Jocelyn M Darby, +7 authors, Amanda L Patchett.
Sci Adv, 2020 Sep 17; 6(27). PMID: 32937435    Free PMC article.
NLRC5 regulates expression of MHC-I and provides a target for anti-tumor immunity in transmissible cancers.
Chrissie E B Ong, Amanda L Patchett, +5 authors, Andrew S Flies.
J Cancer Res Clin Oncol, 2021 Apr 03; 147(7). PMID: 33797607    Free PMC article.
Applied ecoimmunology: using immunological tools to improve conservation efforts in a changing world.
Michel E B Ohmer, David Costantini, +8 authors, Rebecca L Cramp.
Conserv Physiol, 2021 Sep 14; 9(1). PMID: 34512994    Free PMC article.
Spatial variation in gene expression of Tasmanian devil facial tumors despite minimal host transcriptomic response to infection.
Christopher P Kozakiewicz, Alexandra K Fraik, +8 authors, Andrew Storfer.
BMC Genomics, 2021 Sep 29; 22(1). PMID: 34579650    Free PMC article.