Review
. 2017 May; 17(9):559-572.
doi: 10.1038/nri.2017.49.

Chemokines in the cancer microenvironment and their relevance in cancer immunotherapy

Nisha Nagarsheth 1 Max S Wicha 2 Weiping Zou 1 
Affiliations
  • PMID: 28555670
  •     212 References
  •     373 citations

Abstract

The tumour microenvironment is the primary location in which tumour cells and the host immune system interact. Different immune cell subsets are recruited into the tumour microenvironment via interactions between chemokines and chemokine receptors, and these populations have distinct effects on tumour progression and therapeutic outcomes. In this Review, we focus on the main chemokines that are found in the human tumour microenvironment; we elaborate on their patterns of expression, their regulation and their roles in immune cell recruitment and in cancer and stromal cell biology, and we consider how they affect cancer immunity and tumorigenesis. We also discuss the potential of targeting chemokine networks, in combination with other immunotherapies, for the treatment of cancer.

Regulation of inflammatory responses by gut microbiota and chemoattractant receptor GPR43.
Kendle M Maslowski, Angelica T Vieira, +10 authors, Charles R Mackay.
Nature, 2009 Oct 30; 461(7268). PMID: 19865172    Free PMC article.
Highly Cited.
Effector memory T cells, early metastasis, and survival in colorectal cancer.
Franck Pagès, Anne Berger, +13 authors, Jérôme Galon.
N Engl J Med, 2005 Dec 24; 353(25). PMID: 16371631
Highly Cited.
Immunogenic calreticulin exposure occurs through a phylogenetically conserved stress pathway involving the chemokine CXCL8.
A Q Sukkurwala, I Martins, +15 authors, G Kroemer.
Cell Death Differ, 2013 Jun 22; 21(1). PMID: 23787997    Free PMC article.
Loss of new chemokine CXCL14 in tumor tissue is associated with low infiltration by dendritic cells (DC), while restoration of human CXCL14 expression in tumor cells causes attraction of DC both in vitro and in vivo.
Galina V Shurin, Robert L Ferris, +7 authors, Michael R Shurin.
J Immunol, 2005 Apr 22; 174(9). PMID: 15843547
Intratumoral T cells, recurrence, and survival in epithelial ovarian cancer.
Lin Zhang, Jose R Conejo-Garcia, +9 authors, George Coukos.
N Engl J Med, 2003 Jan 17; 348(3). PMID: 12529460
Highly Cited.
CCL18 promotes epithelial-mesenchymal transition, invasion and migration of pancreatic cancer cells in pancreatic ductal adenocarcinoma.
Fanbin Meng, Wan Li, +3 authors, Shaowei Song.
Int J Oncol, 2014 Dec 17; 46(3). PMID: 25502147
IL-8 signaling plays a critical role in the epithelial-mesenchymal transition of human carcinoma cells.
Romaine I Fernando, Marianne D Castillo, +2 authors, Claudia Palena.
Cancer Res, 2011 Jun 10; 71(15). PMID: 21653678    Free PMC article.
Highly Cited.
Anticancer immunotherapy by CTLA-4 blockade relies on the gut microbiota.
Marie Vétizou, Jonathan M Pitt, +35 authors, Laurence Zitvogel.
Science, 2015 Nov 07; 350(6264). PMID: 26541610    Free PMC article.
Highly Cited.
Expression of CXCL14 and its anticancer role in breast cancer.
Xiao-Li Gu, Zhou-Luo Ou, +4 authors, Zhi-Ming Shao.
Breast Cancer Res Treat, 2012 Aug 23; 135(3). PMID: 22910931
A point mutation (G574A) in the chemokine receptor CXCR4 detected in human cancer cells enhances migration.
Caterina Ierano, Paola Giuliano, +13 authors, Stefania Scala.
Cell Cycle, 2009 Mar 24; 8(8). PMID: 19305148
The chemokine SDF-1/CXCL12 binds to and signals through the orphan receptor RDC1 in T lymphocytes.
Karl Balabanian, Bernard Lagane, +6 authors, Françoise Bachelerie.
J Biol Chem, 2005 Aug 19; 280(42). PMID: 16107333
Highly Cited.
Hypoxia-induced elevation in interleukin-8 expression by human ovarian carcinoma cells.
L Xu, K Xie, +2 authors, I J Fidler.
Cancer Res, 1999 Dec 03; 59(22). PMID: 10582705
Progenitor cell trafficking is regulated by hypoxic gradients through HIF-1 induction of SDF-1.
Daniel J Ceradini, Anita R Kulkarni, +7 authors, Geoffrey C Gurtner.
Nat Med, 2004 Jul 06; 10(8). PMID: 15235597
Highly Cited.
Tumor-activated monocytes promote expansion of IL-17-producing CD8+ T cells in hepatocellular carcinoma patients.
Dong-Ming Kuang, Chen Peng, +6 authors, Limin Zheng.
J Immunol, 2010 Jun 29; 185(3). PMID: 20581151
CCR9 mediates PI3K/AKT-dependent antiapoptotic signals in prostate cancer cells and inhibition of CCR9-CCL25 interaction enhances the cytotoxic effects of etoposide.
Praveen K Sharma, Rajesh Singh, +3 authors, Shailesh Singh.
Int J Cancer, 2010 Feb 04; 127(9). PMID: 20127861
Differential estrogen-regulation of CXCL12 chemokine receptors, CXCR4 and CXCR7, contributes to the growth effect of estrogens in breast cancer cells.
Antoine Boudot, Gwenneg Kerdivel, +5 authors, Farzad Pakdel.
PLoS One, 2011 Jun 23; 6(6). PMID: 21695171    Free PMC article.
Immune checkpoint blockade: a common denominator approach to cancer therapy.
Suzanne L Topalian, Charles G Drake, Drew M Pardoll.
Cancer Cell, 2015 Apr 11; 27(4). PMID: 25858804    Free PMC article.
Highly Cited. Review.
Surface phenotype and antigenic specificity of human interleukin 17-producing T helper memory cells.
Eva V Acosta-Rodriguez, Laura Rivino, +5 authors, Giorgio Napolitani.
Nat Immunol, 2007 May 09; 8(6). PMID: 17486092
Highly Cited.
PD-L1 (B7-H1) and PD-1 pathway blockade for cancer therapy: Mechanisms, response biomarkers, and combinations.
Weiping Zou, Jedd D Wolchok, Lieping Chen.
Sci Transl Med, 2016 Mar 05; 8(328). PMID: 26936508    Free PMC article.
Highly Cited. Review.
A case for regulatory B cells.
Atsushi Mizoguchi, Atul K Bhan.
J Immunol, 2006 Jan 06; 176(2). PMID: 16393950
Highly Cited. Review.
CXCR7 (RDC1) promotes breast and lung tumor growth in vivo and is expressed on tumor-associated vasculature.
Zhenhua Miao, Kathryn E Luker, +9 authors, Thomas J Schall.
Proc Natl Acad Sci U S A, 2007 Sep 28; 104(40). PMID: 17898181    Free PMC article.
Highly Cited.
Human TH17 cells are long-lived effector memory cells.
Ilona Kryczek, Ende Zhao, +7 authors, Weiping Zou.
Sci Transl Med, 2011 Oct 15; 3(104). PMID: 21998407    Free PMC article.
Highly Cited.
AMD3100, a small molecule inhibitor of HIV-1 entry via the CXCR4 co-receptor.
G A Donzella, D Schols, +8 authors, J P Moore.
Nat Med, 1998 Jan 14; 4(1). PMID: 9427609
Highly Cited.
Chemokines and cellular plasticity of ovarian cancer stem cells.
Weiping Zou, Max S Wicha.
Oncoscience, 2015 Sep 04; 2(7). PMID: 26328269    Free PMC article.
Arginase I in myeloid suppressor cells is induced by COX-2 in lung carcinoma.
Paulo C Rodriguez, Claudia P Hernandez, +5 authors, Augusto C Ochoa.
J Exp Med, 2005 Sep 28; 202(7). PMID: 16186186    Free PMC article.
Highly Cited.
T(H)17 cells in tumour immunity and immunotherapy.
Weiping Zou, Nicholas P Restifo.
Nat Rev Immunol, 2010 Mar 26; 10(4). PMID: 20336152    Free PMC article.
Highly Cited. Review.
Mast cells induce epithelial-to-mesenchymal transition and stem cell features in human thyroid cancer cells through an IL-8-Akt-Slug pathway.
C Visciano, F Liotti, +7 authors, R M Melillo.
Oncogene, 2015 Jan 27; 34(40). PMID: 25619830
Highly Cited.
Noncompetitive allosteric inhibitors of the inflammatory chemokine receptors CXCR1 and CXCR2: prevention of reperfusion injury.
Riccardo Bertini, Marcello Allegretti, +27 authors, Francesco Colotta.
Proc Natl Acad Sci U S A, 2004 Jul 30; 101(32). PMID: 15282370    Free PMC article.
Bone marrow and the control of immunity.
Ende Zhao, Huanbin Xu, +5 authors, Weiping Zou.
Cell Mol Immunol, 2011 Oct 25; 9(1). PMID: 22020068    Free PMC article.
Review.
Melanoma-intrinsic β-catenin signalling prevents anti-tumour immunity.
Stefani Spranger, Riyue Bao, Thomas F Gajewski.
Nature, 2015 May 15; 523(7559). PMID: 25970248
Highly Cited.
Mitochondrial dysfunction and reactive oxygen species imbalance promote breast cancer cell motility through a CXCL14-mediated mechanism.
Helene Pelicano, Weiqin Lu, +4 authors, Peng Huang.
Cancer Res, 2009 Mar 12; 69(6). PMID: 19276362    Free PMC article.
The CC chemokine RANTES in breast carcinoma progression: regulation of expression and potential mechanisms of promalignant activity.
Elina Azenshtein, Galia Luboshits, +6 authors, Adit Ben-Baruch.
Cancer Res, 2002 Feb 28; 62(4). PMID: 11861388
CD20+ B cells: the other tumor-infiltrating lymphocytes.
Brad H Nelson.
J Immunol, 2010 Oct 22; 185(9). PMID: 20962266
Highly Cited. Review.
Elevated expression of the CC chemokine regulated on activation, normal T cell expressed and secreted (RANTES) in advanced breast carcinoma.
G Luboshits, S Shina, +6 authors, A Ben-Baruch.
Cancer Res, 1999 Sep 24; 59(18). PMID: 10493525
CCR9/CCL25 expression in non-small cell lung cancer correlates with aggressive disease and mediates key steps of metastasis.
Pranav Gupta, Praveen K Sharma, +5 authors, Shailesh Singh.
Oncotarget, 2014 Oct 10; 5(20). PMID: 25296976    Free PMC article.
Phenotype, distribution, generation, and functional and clinical relevance of Th17 cells in the human tumor environments.
Ilona Kryczek, Mousumi Banerjee, +11 authors, Weiping Zou.
Blood, 2009 May 28; 114(6). PMID: 19470694    Free PMC article.
Highly Cited.
Decitabine Enhances Lymphocyte Migration and Function and Synergizes with CTLA-4 Blockade in a Murine Ovarian Cancer Model.
Lei Wang, Zohreh Amoozgar, +4 authors, Michael S Goldberg.
Cancer Immunol Res, 2015 Jun 10; 3(9). PMID: 26056145
High macrophage infiltration along the tumor front correlates with improved survival in colon cancer.
Johan Forssell, Ake Oberg, +3 authors, Richard Palmqvist.
Clin Cancer Res, 2007 Mar 03; 13(5). PMID: 17332291
Highly Cited.
HIF-1 and NF-kappaB-mediated upregulation of CXCR1 and CXCR2 expression promotes cell survival in hypoxic prostate cancer cells.
P J Maxwell, R Gallagher, +7 authors, D J J Waugh.
Oncogene, 2007 May 30; 26(52). PMID: 17533374
Chemokines: agents for the immunotherapy of cancer?
Bernhard Homey, Anja Müller, Albert Zlotnik.
Nat Rev Immunol, 2002 Mar 27; 2(3). PMID: 11913068
Review.
Alterations of immune response of Non-Small Cell Lung Cancer with Azacytidine.
John Wrangle, Wei Wang, +25 authors, Stephen B Baylin.
Oncotarget, 2013 Oct 29; 4(11). PMID: 24162015    Free PMC article.
Highly Cited.
Immune regulation by low doses of the DNA methyltransferase inhibitor 5-azacitidine in common human epithelial cancers.
Huili Li, Katherine B Chiappinelli, +15 authors, Nita Ahuja.
Oncotarget, 2014 Mar 04; 5(3). PMID: 24583822    Free PMC article.
Highly Cited.
IL-8 confers resistance to EGFR inhibitors by inducing stem cell properties in lung cancer.
Yi-Nan Liu, Tzu-Hua Chang, +6 authors, Jin-Yuan Shih.
Oncotarget, 2015 Apr 15; 6(12). PMID: 25871388    Free PMC article.
CCR9 in cancer: oncogenic role and therapeutic targeting.
Zhenbo Tu, Ruijing Xiao, +6 authors, Qiuping Zhang.
J Hematol Oncol, 2016 Feb 18; 9. PMID: 26879872    Free PMC article.
Review.
The humoral immune system has a key prognostic impact in node-negative breast cancer.
Marcus Schmidt, Daniel Böhm, +7 authors, Mathias Gehrmann.
Cancer Res, 2008 Jul 03; 68(13). PMID: 18593943
Highly Cited.
CD169-positive macrophages dominate antitumor immunity by crosspresenting dead cell-associated antigens.
Kenichi Asano, Ami Nabeyama, +6 authors, Masato Tanaka.
Immunity, 2011 Jan 05; 34(1). PMID: 21194983
Highly Cited.
Interferon gamma-inducible protein 10 (IP-10), a member of the C-X-C chemokine family, is an inhibitor of angiogenesis.
R M Strieter, S L Kunkel, +2 authors, P J Polverini.
Biochem Biophys Res Commun, 1995 May 05; 210(1). PMID: 7537965
CXCL17 expression by tumor cells recruits CD11b+Gr1 high F4/80- cells and promotes tumor progression.
Aya Matsui, Hideaki Yokoo, +10 authors, Takashi Murakami.
PLoS One, 2012 Sep 07; 7(8). PMID: 22952881    Free PMC article.
CSF1/CSF1R blockade reprograms tumor-infiltrating macrophages and improves response to T-cell checkpoint immunotherapy in pancreatic cancer models.
Yu Zhu, Brett L Knolhoff, +7 authors, David G DeNardo.
Cancer Res, 2014 Aug 02; 74(18). PMID: 25082815    Free PMC article.
Highly Cited.
CXCR4 neutralization, a novel therapeutic approach for non-Hodgkin's lymphoma.
Francesco Bertolini, Chiara Dell'Agnola, +6 authors, Giovanni Martinelli.
Cancer Res, 2002 May 31; 62(11). PMID: 12036921
Cancer mediates effector T cell dysfunction by targeting microRNAs and EZH2 via glycolysis restriction.
Ende Zhao, Tomasz Maj, +22 authors, Weiping Zou.
Nat Immunol, 2015 Nov 03; 17(1). PMID: 26523864    Free PMC article.
Highly Cited.
CCL2 mediates cross-talk between cancer cells and stromal fibroblasts that regulates breast cancer stem cells.
Akihiro Tsuyada, Amy Chow, +16 authors, Shizhen Emily Wang.
Cancer Res, 2012 Apr 05; 72(11). PMID: 22472119    Free PMC article.
Highly Cited.
Specific recruitment of regulatory T cells in ovarian carcinoma fosters immune privilege and predicts reduced survival.
Tyler J Curiel, George Coukos, +18 authors, Weiping Zou.
Nat Med, 2004 Aug 24; 10(9). PMID: 15322536
Highly Cited.
VCC-1, a novel chemokine, promotes tumor growth.
Edward J Weinstein, Richard Head, +5 authors, Richard Mazzarella.
Biochem Biophys Res Commun, 2006 Sep 23; 350(1). PMID: 16989774
Role of high expression levels of CXCR4 in tumor growth, vascularization, and metastasis.
Merav Darash-Yahana, Eli Pikarsky, +8 authors, Amnon Peled.
FASEB J, 2004 Jun 08; 18(11). PMID: 15180966
Highly Cited.
CCL2 recruits inflammatory monocytes to facilitate breast-tumour metastasis.
Bin-Zhi Qian, Jiufeng Li, +6 authors, Jeffrey W Pollard.
Nature, 2011 Jun 10; 475(7355). PMID: 21654748    Free PMC article.
Highly Cited.
Endothelial CCR2 signaling induced by colon carcinoma cells enables extravasation via the JAK2-Stat5 and p38MAPK pathway.
Monika Julia Wolf, Alexandra Hoos, +17 authors, Mathias Heikenwalder.
Cancer Cell, 2012 Jul 14; 22(1). PMID: 22789541
Highly Cited.
A novel chemokine receptor for SDF-1 and I-TAC involved in cell survival, cell adhesion, and tumor development.
Jennifer M Burns, Bretton C Summers, +12 authors, Thomas J Schall.
J Exp Med, 2006 Aug 31; 203(9). PMID: 16940167    Free PMC article.
Highly Cited.
T helper 17 cells promote cytotoxic T cell activation in tumor immunity.
Natalia Martin-Orozco, Pawel Muranski, +7 authors, Chen Dong.
Immunity, 2009 Nov 03; 31(5). PMID: 19879162    Free PMC article.
Highly Cited.
Up-regulation of the chemokine CCL18 by macrophages is a potential immunomodulatory pathway in cutaneous T-cell lymphoma.
Claudia Günther, Nick Zimmermann, +4 authors, Michael Meurer.
Am J Pathol, 2011 Jul 12; 179(3). PMID: 21741937    Free PMC article.
Plasmacytoid dendritic cells induce CD8+ regulatory T cells in human ovarian carcinoma.
Shuang Wei, Ilona Kryczek, +6 authors, Weiping Zou.
Cancer Res, 2005 Jun 17; 65(12). PMID: 15958543
Highly Cited.
NF-kappaB promotes breast cancer cell migration and metastasis by inducing the expression of the chemokine receptor CXCR4.
Gregory Helbig, Kent W Christopherson, +5 authors, Harikrishna Nakshatri.
J Biol Chem, 2003 Apr 12; 278(24). PMID: 12690099
Highly Cited.
Chemokines and chemokine receptors: positioning cells for host defense and immunity.
Jason W Griffith, Caroline L Sokol, Andrew D Luster.
Annu Rev Immunol, 2014 Mar 25; 32. PMID: 24655300
Highly Cited. Review.
Fusobacterium nucleatum potentiates intestinal tumorigenesis and modulates the tumor-immune microenvironment.
Aleksandar D Kostic, Eunyoung Chun, +12 authors, Wendy S Garrett.
Cell Host Microbe, 2013 Aug 21; 14(2). PMID: 23954159    Free PMC article.
Highly Cited.
Immunosuppressive networks in the tumour environment and their therapeutic relevance.
Weiping Zou.
Nat Rev Cancer, 2005 Mar 19; 5(4). PMID: 15776005
Highly Cited. Review.
SNAIL regulates interleukin-8 expression, stem cell-like activity, and tumorigenicity of human colorectal carcinoma cells.
Wei-Lun Hwang, Muh-Hwa Yang, +8 authors, Hsei-Wei Wang.
Gastroenterology, 2011 Jun 07; 141(1). PMID: 21640118
Highly Cited.
CCL18 differentiates dendritic cells in tolerogenic cells able to prime regulatory T cells in healthy subjects.
Imane Azzaoui, Saliha Ait Yahia, +8 authors, Anne Tsicopoulos.
Blood, 2011 Aug 02; 118(13). PMID: 21803856
Calreticulin exposure dictates the immunogenicity of cancer cell death.
Michel Obeid, Antoine Tesniere, +14 authors, Guido Kroemer.
Nat Med, 2006 Dec 26; 13(1). PMID: 17187072
Highly Cited.
Beta-arrestin- but not G protein-mediated signaling by the "decoy" receptor CXCR7.
Sudarshan Rajagopal, Jihee Kim, +5 authors, Robert J Lefkowitz.
Proc Natl Acad Sci U S A, 2009 Dec 19; 107(2). PMID: 20018651    Free PMC article.
Highly Cited.
Bone marrow is a reservoir for CD4+CD25+ regulatory T cells that traffic through CXCL12/CXCR4 signals.
Linhua Zou, Brian Barnett, +7 authors, Weiping Zou.
Cancer Res, 2004 Nov 19; 64(22). PMID: 15548717
Highly Cited.
Activation of CCR9/CCL25 in cutaneous melanoma mediates preferential metastasis to the small intestine.
Farin F Amersi, Alicia M Terando, +6 authors, Dave S B Hoon.
Clin Cancer Res, 2008 Feb 05; 14(3). PMID: 18245522    Free PMC article.
Expression profiling identifies chemokine (C-C motif) ligand 18 as an independent prognostic indicator in gastric cancer.
Suet Yi Leung, Siu Tsan Yuen, +7 authors, Samuel So.
Gastroenterology, 2004 Aug 10; 127(2). PMID: 15300578
CCL18 from tumor-cells promotes epithelial ovarian cancer metastasis via mTOR signaling pathway.
Qi Wang, Yong Tang, +6 authors, Li Li.
Mol Carcinog, 2015 Oct 13; 55(11). PMID: 26457987    Free PMC article.
Gr-1+CD115+ immature myeloid suppressor cells mediate the development of tumor-induced T regulatory cells and T-cell anergy in tumor-bearing host.
Bo Huang, Ping-Ying Pan, +5 authors, Shu-Hsia Chen.
Cancer Res, 2006 Jan 21; 66(2). PMID: 16424049
Highly Cited.
Biological and pathological activities of interleukin-22.
Mirna Perusina Lanfranca, Yanwei Lin, +2 authors, Timothy Frankel.
J Mol Med (Berl), 2016 Mar 01; 94(5). PMID: 26923718    Free PMC article.
Review.
IL-8 directly enhanced endothelial cell survival, proliferation, and matrix metalloproteinases production and regulated angiogenesis.
Aihua Li, Seema Dubey, +2 authors, Rakesh K Singh.
J Immunol, 2003 Mar 11; 170(6). PMID: 12626597
Highly Cited.
NKT cells in tumor immunity: opposing subsets define a new immunoregulatory axis.
Jay A Berzofsky, Masaki Terabe.
J Immunol, 2008 Mar 07; 180(6). PMID: 18322166
Review.
CCL25 mediates migration, invasion and matrix metalloproteinase expression by breast cancer cells in a CCR9-dependent fashion.
Crystal Johnson-Holiday, Rajesh Singh, +4 authors, James W Lillard.
Int J Oncol, 2011 Feb 24; 38(5). PMID: 21344163    Free PMC article.
Inhibitory B7-family molecules in the tumour microenvironment.
Weiping Zou, Lieping Chen.
Nat Rev Immunol, 2008 May 27; 8(6). PMID: 18500231
Highly Cited. Review.
The p65 (RelA) subunit of NF-kappaB interacts with the histone deacetylase (HDAC) corepressors HDAC1 and HDAC2 to negatively regulate gene expression.
B P Ashburner, S D Westerheide, A S Baldwin.
Mol Cell Biol, 2001 Sep 21; 21(20). PMID: 11564889    Free PMC article.
Highly Cited.
The interleukin-8 pathway in cancer.
David J J Waugh, Catherine Wilson.
Clin Cancer Res, 2008 Nov 05; 14(21). PMID: 18980965
Highly Cited. Review.
A multigenic program mediating breast cancer metastasis to bone.
Yibin Kang, Peter M Siegel, +5 authors, Joan Massagué.
Cancer Cell, 2003 Jul 05; 3(6). PMID: 12842083
Highly Cited.
Stroma-derived factor (SDF-1/CXCL12) and human tumor pathogenesis.
Ilona Kryczek, Shuang Wei, +2 authors, Weiping Zou.
Am J Physiol Cell Physiol, 2006 Sep 01; 292(3). PMID: 16943240
Highly Cited. Review.
Silencing of CXCR4 blocks breast cancer metastasis.
Zhongxing Liang, Younghyoun Yoon, +3 authors, Hyunsuk Shim.
Cancer Res, 2005 Feb 12; 65(3). PMID: 15705897    Free PMC article.
Highly Cited.
PRC2 Epigenetically Silences Th1-Type Chemokines to Suppress Effector T-Cell Trafficking in Colon Cancer.
Nisha Nagarsheth, Dongjun Peng, +15 authors, Weiping Zou.
Cancer Res, 2015 Nov 15; 76(2). PMID: 26567139    Free PMC article.
Highly Cited.
Involvement of CC chemokine ligand 18 (CCL18) in normal and pathological processes.
Evemie Schutyser, Ann Richmond, Jo Van Damme.
J Leukoc Biol, 2005 Mar 24; 78(1). PMID: 15784687    Free PMC article.
Review.
Expression of CXC chemokine receptor-4 enhances the pulmonary metastatic potential of murine B16 melanoma cells.
Takashi Murakami, Wusi Maki, +4 authors, Sam T Hwang.
Cancer Res, 2002 Dec 25; 62(24). PMID: 12499276
Hypoxia-inducible factor-1 (HIF-1) is involved in the regulation of hypoxia-stimulated expression of monocyte chemoattractant protein-1 (MCP-1/CCL2) and MCP-5 (Ccl12) in astrocytes.
Jelena Mojsilovic-Petrovic, Debbie Callaghan, +3 authors, Wandong Zhang.
J Neuroinflammation, 2007 May 04; 4. PMID: 17474992    Free PMC article.
A comparative study of the cellular immune response in patients with stage IB cervical squamous cell carcinoma. Low numbers of several immune cell subtypes are strongly associated with relapse of disease within 5 years.
Bettina S Nedergaard, Morten Ladekarl, Jens Randel Nyengaard, Karsten Nielsen.
Gynecol Oncol, 2007 Oct 20; 108(1). PMID: 17945335
The gut microbiota--masters of host development and physiology.
Felix Sommer, Fredrik Bäckhed.
Nat Rev Microbiol, 2013 Feb 26; 11(4). PMID: 23435359
Highly Cited. Review.
CCL2/CCR2 chemokine signaling coordinates survival and motility of breast cancer cells through Smad3 protein- and p42/44 mitogen-activated protein kinase (MAPK)-dependent mechanisms.
Wei Bin Fang, Iman Jokar, +3 authors, Nikki Cheng.
J Biol Chem, 2012 Aug 29; 287(43). PMID: 22927430    Free PMC article.
Highly Cited.
Leukocyte complexity predicts breast cancer survival and functionally regulates response to chemotherapy.
David G DeNardo, Donal J Brennan, +12 authors, Lisa M Coussens.
Cancer Discov, 2011 Nov 01; 1(1). PMID: 22039576    Free PMC article.
Highly Cited.
Significant correlation of monocyte chemoattractant protein-1 expression with neovascularization and progression of breast carcinoma.
H Saji, M Koike, +4 authors, M Toi.
Cancer, 2001 Sep 26; 92(5). PMID: 11571719
Stromal-derived factor-1 in human tumors recruits and alters the function of plasmacytoid precursor dendritic cells.
W Zou, V Machelon, +13 authors, T J Curiel.
Nat Med, 2001 Dec 01; 7(12). PMID: 11726975
Highly Cited.
Th22 cell accumulation is associated with colorectal cancer development.
Yong-Hong Huang, Yun-Fei Cao, +2 authors, Feng Gao.
World J Gastroenterol, 2015 Apr 22; 21(14). PMID: 25892871    Free PMC article.
The role of CXCR7/RDC1 as a chemokine receptor for CXCL12/SDF-1 in prostate cancer.
Jianhua Wang, Yusuke Shiozawa, +6 authors, Russell S Taichman.
J Biol Chem, 2007 Dec 07; 283(7). PMID: 18057003
Highly Cited.
Chemokine signaling via the CXCR2 receptor reinforces senescence.
Juan C Acosta, Ana O'Loghlen, +13 authors, Jesús Gil.
Cell, 2008 Jun 17; 133(6). PMID: 18555777
Highly Cited.
Myeloid-derived suppressor cells as regulators of the immune system.
Dmitry I Gabrilovich, Srinivas Nagaraj.
Nat Rev Immunol, 2009 Feb 07; 9(3). PMID: 19197294    Free PMC article.
Highly Cited. Review.
In vivo expression of the novel CXC chemokine BRAK in normal and cancerous human tissue.
M J Frederick, Y Henderson, +6 authors, G L Clayman.
Am J Pathol, 2000 Jun 15; 156(6). PMID: 10854217    Free PMC article.
EZH2 inhibition as a therapeutic strategy for lymphoma with EZH2-activating mutations.
Michael T McCabe, Heidi M Ott, +19 authors, Caretha L Creasy.
Nature, 2012 Oct 12; 492(7427). PMID: 23051747
Highly Cited.
Upregulation of CXCR4 is functionally crucial for maintenance of stemness in drug-resistant non-small cell lung cancer cells.
M-J Jung, J-K Rho, +7 authors, M-J Park.
Oncogene, 2012 Mar 01; 32(2). PMID: 22370645
Highly Cited.
In breast carcinoma tissue, immature dendritic cells reside within the tumor, whereas mature dendritic cells are located in peritumoral areas.
D Bell, P Chomarat, +7 authors, J Banchereau.
J Exp Med, 1999 Nov 24; 190(10). PMID: 10562317    Free PMC article.
Highly Cited.
The potential role of neutrophils in promoting the metastatic phenotype of tumors releasing interleukin-8.
Joseph E De Larco, Beverly R K Wuertz, Leo T Furcht.
Clin Cancer Res, 2004 Aug 07; 10(15). PMID: 15297389
Highly Cited.
Commensal Bifidobacterium promotes antitumor immunity and facilitates anti-PD-L1 efficacy.
Ayelet Sivan, Leticia Corrales, +9 authors, Thomas F Gajewski.
Science, 2015 Nov 07; 350(6264). PMID: 26541606    Free PMC article.
Highly Cited.
Cloning of BRAK, a novel divergent CXC chemokine preferentially expressed in normal versus malignant cells.
R Hromas, H E Broxmeyer, +4 authors, Y H Hou.
Biochem Biophys Res Commun, 1999 Mar 02; 255(3). PMID: 10049774
Tumor-associated macrophages produce interleukin 6 and signal via STAT3 to promote expansion of human hepatocellular carcinoma stem cells.
Shanshan Wan, Ende Zhao, +6 authors, Theodore H Welling.
Gastroenterology, 2014 Sep 03; 147(6). PMID: 25181692    Free PMC article.
Highly Cited.
Trophic macrophages in development and disease.
Jeffrey W Pollard.
Nat Rev Immunol, 2009 Mar 14; 9(4). PMID: 19282852    Free PMC article.
Highly Cited. Review.
Epigenetic silencing of TH1-type chemokines shapes tumour immunity and immunotherapy.
Dongjun Peng, Ilona Kryczek, +15 authors, Weiping Zou.
Nature, 2015 Oct 28; 527(7577). PMID: 26503055    Free PMC article.
Highly Cited.
Epithelial cancer cell migration: a role for chemokine receptors?
C J Scotton, J L Wilson, +2 authors, F R Balkwill.
Cancer Res, 2001 Jun 30; 61(13). PMID: 11431324
Inflammatory regulatory T cells in the microenvironments of ulcerative colitis and colon carcinoma.
Ilona Kryczek, Lin Wang, +15 authors, Weiping Zou.
Oncoimmunology, 2016 Sep 14; 5(8). PMID: 27622054    Free PMC article.
Cancer as a dysregulated epigenome allowing cellular growth advantage at the expense of the host.
Winston Timp, Andrew P Feinberg.
Nat Rev Cancer, 2013 Jun 14; 13(7). PMID: 23760024    Free PMC article.
Highly Cited. Review.
CXCR1 blockade selectively targets human breast cancer stem cells in vitro and in xenografts.
Christophe Ginestier, Suling Liu, +10 authors, Max S Wicha.
J Clin Invest, 2010 Jan 07; 120(2). PMID: 20051626    Free PMC article.
Highly Cited.
IL-22BP is regulated by the inflammasome and modulates tumorigenesis in the intestine.
Samuel Huber, Nicola Gagliani, +14 authors, Richard A Flavell.
Nature, 2012 Oct 19; 491(7423). PMID: 23075849    Free PMC article.
Highly Cited.
CCL2-induced chemokine cascade promotes breast cancer metastasis by enhancing retention of metastasis-associated macrophages.
Takanori Kitamura, Bin-Zhi Qian, +6 authors, Jeffrey W Pollard.
J Exp Med, 2015 Jun 10; 212(7). PMID: 26056232    Free PMC article.
Highly Cited.
Myeloid-Derived Suppressor Cells Endow Stem-like Qualities to Breast Cancer Cells through IL6/STAT3 and NO/NOTCH Cross-talk Signaling.
Dongjun Peng, Takashi Tanikawa, +20 authors, Ilona Kryczek.
Cancer Res, 2016 May 20; 76(11). PMID: 27197152    Free PMC article.
Highly Cited.
The distribution of macrophages with a M1 or M2 phenotype in relation to prognosis and the molecular characteristics of colorectal cancer.
Sofia Edin, Maria L Wikberg, +4 authors, Richard Palmqvist.
PLoS One, 2012 Oct 19; 7(10). PMID: 23077543    Free PMC article.
Highly Cited.
Targeting HIF-1 for cancer therapy.
Gregg L Semenza.
Nat Rev Cancer, 2003 Sep 18; 3(10). PMID: 13130303
Highly Cited. Review.
Cessation of CCL2 inhibition accelerates breast cancer metastasis by promoting angiogenesis.
Laura Bonapace, Marie-May Coissieux, +4 authors, Mohamed Bentires-Alj.
Nature, 2014 Oct 23; 515(7525). PMID: 25337873
Highly Cited.
CC chemokine ligand 18 correlates with malignant progression of prostate cancer.
Guo Chen, Yu-xiang Liang, +11 authors, Wei-de Zhong.
Biomed Res Int, 2014 Sep 10; 2014. PMID: 25197632    Free PMC article.
Chemokines in innate and adaptive host defense: basic chemokinese grammar for immune cells.
Antal Rot, Ulrich H von Andrian.
Annu Rev Immunol, 2004 Mar 23; 22. PMID: 15032599
Highly Cited. Review.
A small-molecule antagonist of CXCR4 inhibits intracranial growth of primary brain tumors.
Joshua B Rubin, Andrew L Kung, +6 authors, Rosalind A Segal.
Proc Natl Acad Sci U S A, 2003 Nov 05; 100(23). PMID: 14595012    Free PMC article.
Highly Cited.
Modulation of CXCL14 (BRAK) expression in prostate cancer.
Steven R Schwarze, Jun Luo, William B Isaacs, David F Jarrard.
Prostate, 2005 Jan 15; 64(1). PMID: 15651028
Autocrine CCL5 signaling promotes invasion and migration of CD133+ ovarian cancer stem-like cells via NF-κB-mediated MMP-9 upregulation.
Haixia Long, Rongkai Xie, +5 authors, Bo Zhu.
Stem Cells, 2012 Aug 14; 30(10). PMID: 22887854
B7-H4 expression identifies a novel suppressive macrophage population in human ovarian carcinoma.
Ilona Kryczek, Linhua Zou, +12 authors, Weiping Zou.
J Exp Med, 2006 Apr 12; 203(4). PMID: 16606666    Free PMC article.
Highly Cited.
Activated monocytes in peritumoral stroma of hepatocellular carcinoma foster immune privilege and disease progression through PD-L1.
Dong-Ming Kuang, Qiyi Zhao, +4 authors, Limin Zheng.
J Exp Med, 2009 May 20; 206(6). PMID: 19451266    Free PMC article.
Highly Cited.
Type, density, and location of immune cells within human colorectal tumors predict clinical outcome.
Jérôme Galon, Anne Costes, +13 authors, Franck Pagès.
Science, 2006 Sep 30; 313(5795). PMID: 17008531
Highly Cited.
Expression and functional role of CCR9 in prostate cancer cell migration and invasion.
Shailesh Singh, Udai P Singh, +2 authors, James W Lillard.
Clin Cancer Res, 2004 Dec 30; 10(24). PMID: 15623660
Ectopic expression of the chemokine CXCL17 in colon cancer cells.
Lina Ohlsson, Marie-Louise Hammarström, +2 authors, Basel Sitohy.
Br J Cancer, 2016 Feb 19; 114(6). PMID: 26889977    Free PMC article.
The chemokine CCL18 causes maturation of cultured monocytes to macrophages in the M2 spectrum.
Ingrid U Schraufstatter, Ming Zhao, Sophia K Khaldoyanidi, Richard G Discipio.
Immunology, 2011 Nov 29; 135(4). PMID: 22117697    Free PMC article.
Multiple actions of the chemokine CXCL12 on epithelial tumor cells in human ovarian cancer.
Chris J Scotton, Julia L Wilson, +5 authors, Frances R Balkwill.
Cancer Res, 2002 Oct 18; 62(20). PMID: 12384559
Highly Cited.
Involvement of chemokine receptors in breast cancer metastasis.
A Müller, B Homey, +11 authors, A Zlotnik.
Nature, 2001 Mar 10; 410(6824). PMID: 11242036
Highly Cited.
Chemokine stimulation of monocyte matrix metalloproteinase-9 requires endogenous TNF-alpha.
Stephen C Robinson, Kate A Scott, Frances R Balkwill.
Eur J Immunol, 2002 Jan 29; 32(2). PMID: 11813159
Tumor-induced tolerance and immune suppression depend on the C/EBPbeta transcription factor.
Ilaria Marigo, Erika Bosio, +13 authors, Vincenzo Bronte.
Immunity, 2010 Jul 08; 32(6). PMID: 20605485
Highly Cited.
Cell cycle-dependent expression of CXC chemokine receptor 3 by endothelial cells mediates angiostatic activity.
P Romagnani, F Annunziato, +11 authors, M Serio.
J Clin Invest, 2001 Jan 03; 107(1). PMID: 11134180    Free PMC article.
CD133(+)CXCR4(+) colon cancer cells exhibit metastatic potential and predict poor prognosis of patients.
Shan-shan Zhang, Zhi-peng Han, +13 authors, Li-xin Wei.
BMC Med, 2012 Aug 09; 10. PMID: 22871210    Free PMC article.
Regulatory T cells, tumour immunity and immunotherapy.
Weiping Zou.
Nat Rev Immunol, 2006 Mar 25; 6(4). PMID: 16557261
Highly Cited. Review.
Tumor-induced STAT3 activation in monocytic myeloid-derived suppressor cells enhances stemness and mesenchymal properties in human pancreatic cancer.
Roheena Z Panni, Dominic E Sanford, +9 authors, David C Linehan.
Cancer Immunol Immunother, 2014 Mar 22; 63(5). PMID: 24652403    Free PMC article.
Highly Cited.
CD133+ ovarian cancer stem-like cells promote non-stem cancer cell metastasis via CCL5 induced epithelial-mesenchymal transition.
Haixia Long, Tong Xiang, +8 authors, Bo Zhu.
Oncotarget, 2015 Mar 20; 6(8). PMID: 25788271    Free PMC article.
Th17 cells have stem cell-like features and promote long-term immunity.
Shuang Wei, Ende Zhao, Ilona Kryczek, Weiping Zou.
Oncoimmunology, 2012 Jul 04; 1(4). PMID: 22754771    Free PMC article.
CXCR4-SDF-1 signaling is active in rhabdomyosarcoma cells and regulates locomotion, chemotaxis, and adhesion.
Jolanta Libura, Justyna Drukala, +8 authors, Mariusz Z Ratajczak.
Blood, 2002 Sep 20; 100(7). PMID: 12239174
Oncogene MYCN regulates localization of NKT cells to the site of disease in neuroblastoma.
Liping Song, Tasnim Ara, +7 authors, Leonid S Metelitsa.
J Clin Invest, 2007 Aug 22; 117(9). PMID: 17710228    Free PMC article.
Functional CCR9 expression is associated with small intestinal metastasis.
Anne Letsch, Ulrich Keilholz, +4 authors, Carmen Scheibenbogen.
J Invest Dermatol, 2004 Apr 17; 122(3). PMID: 15086554
FcRgamma activation regulates inflammation-associated squamous carcinogenesis.
Pauline Andreu, Magnus Johansson, +11 authors, Lisa M Coussens.
Cancer Cell, 2010 Feb 09; 17(2). PMID: 20138013    Free PMC article.
Highly Cited.
Systematic analysis of immune infiltrates in high-grade serous ovarian cancer reveals CD20, FoxP3 and TIA-1 as positive prognostic factors.
Katy Milne, Martin Köbel, +5 authors, Brad H Nelson.
PLoS One, 2009 Jul 31; 4(7). PMID: 19641607    Free PMC article.
Highly Cited.
Induction of IL-17+ T cell trafficking and development by IFN-gamma: mechanism and pathological relevance in psoriasis.
Ilona Kryczek, Allen T Bruce, +9 authors, Weiping Zou.
J Immunol, 2008 Sep 20; 181(7). PMID: 18802076    Free PMC article.
Highly Cited.
Lactate influx through the endothelial cell monocarboxylate transporter MCT1 supports an NF-κB/IL-8 pathway that drives tumor angiogenesis.
Frédérique Végran, Romain Boidot, +2 authors, Olivier Feron.
Cancer Res, 2011 Feb 09; 71(7). PMID: 21300765
Highly Cited.
CCR9 interactions support ovarian cancer cell survival and resistance to cisplatin-induced apoptosis in a PI3K-dependent and FAK-independent fashion.
Erica L Johnson, Rajesh Singh, +4 authors, Shailesh Singh.
J Ovarian Res, 2010 Jun 23; 3. PMID: 20565782    Free PMC article.
Tertiary Lymphoid Structure-Associated B Cells are Key Players in Anti-Tumor Immunity.
Claire Germain, Sacha Gnjatic, Marie-Caroline Dieu-Nosjean.
Front Immunol, 2015 Mar 11; 6. PMID: 25755654    Free PMC article.
Review.
CXCR4 knockdown by small interfering RNA abrogates breast tumor growth in vivo.
Natalia Lapteva, An-Gang Yang, +2 authors, Si-Yi Chen.
Cancer Gene Ther, 2004 Oct 09; 12(1). PMID: 15472715
Angiogenesis in cancer and other diseases.
P Carmeliet, R K Jain.
Nature, 2000 Sep 23; 407(6801). PMID: 11001068
Highly Cited. Review.
Macrophage regulation of tumor responses to anticancer therapies.
Michele De Palma, Claire E Lewis.
Cancer Cell, 2013 Mar 23; 23(3). PMID: 23518347
Highly Cited. Review.
The chemokine receptor CXCR4 is required for outgrowth of colon carcinoma micrometastases.
Ingrid S Zeelenberg, Lisette Ruuls-Van Stalle, Ed Roos.
Cancer Res, 2003 Jul 04; 63(13). PMID: 12839981
Highly Cited.
B cells regulate macrophage phenotype and response to chemotherapy in squamous carcinomas.
Nesrine I Affara, Brian Ruffell, +13 authors, Lisa M Coussens.
Cancer Cell, 2014 Jun 10; 25(6). PMID: 24909985    Free PMC article.
Highly Cited.
CCL18 from tumor-associated macrophages promotes angiogenesis in breast cancer.
Ling Lin, Yong-Song Chen, +8 authors, Er-Wei Song.
Oncotarget, 2015 Sep 30; 6(33). PMID: 26416449    Free PMC article.
The IL-8/CXCR1 axis is associated with cancer stem cell-like properties and correlates with clinical prognosis in human pancreatic cancer cases.
Lianyu Chen, Jie Fan, +4 authors, Luming Liu.
Sci Rep, 2014 Aug 02; 4. PMID: 25081383    Free PMC article.
B cell- and monocyte-activating chemokine (BMAC), a novel non-ELR alpha-chemokine.
M A Sleeman, J K Fraser, +5 authors, K D Kumble.
Int Immunol, 2000 Apr 28; 12(5). PMID: 10784614
Identification of a distinct population of CD133(+)CXCR4(+) cancer stem cells in ovarian cancer.
Michele Cioffi, Crescenzo D'Alterio, +10 authors, Stefania Scala.
Sci Rep, 2015 May 29; 5. PMID: 26020117    Free PMC article.
Unique regulation of CCL18 production by maturing dendritic cells.
Marisa Vulcano, Sofie Struyf, +10 authors, Silvano Sozzani.
J Immunol, 2003 Mar 21; 170(7). PMID: 12646652
Tumor-specific Th17-polarized cells eradicate large established melanoma.
Pawel Muranski, Andrea Boni, +14 authors, Nicholas P Restifo.
Blood, 2008 Mar 21; 112(2). PMID: 18354038    Free PMC article.
Highly Cited.
Tumour-educated macrophages promote tumour progression and metastasis.
Jeffrey W Pollard.
Nat Rev Cancer, 2004 Jan 07; 4(1). PMID: 14708027
Highly Cited. Review.
Induction of inflammatory angiogenesis by monocyte chemoattractant protein-1.
V Goede, L Brogelli, M Ziche, H G Augustin.
Int J Cancer, 1999 Jul 27; 82(5). PMID: 10417778
Pharmacologic disruption of Polycomb-repressive complex 2-mediated gene repression selectively induces apoptosis in cancer cells.
Jing Tan, Xiaojing Yang, +7 authors, Qiang Yu.
Genes Dev, 2007 Apr 18; 21(9). PMID: 17437993    Free PMC article.
Highly Cited.
Regulatory T cells in the bone marrow microenvironment in patients with prostate cancer.
Ende Zhao, Lin Wang, +8 authors, Weiping Zou.
Oncoimmunology, 2012 Jun 22; 1(2). PMID: 22720236    Free PMC article.
Reparixin, a specific interleukin-8 inhibitor, has no effects on inflammation during endotoxemia.
J M Leitner, F B Mayr, +4 authors, B Jilma.
Int J Immunopathol Pharmacol, 2007 Mar 10; 20(1). PMID: 17346425
Natural killer T cells infiltrate neuroblastomas expressing the chemokine CCL2.
Leonid S Metelitsa, Hong-Wei Wu, +6 authors, Robert C Seeger.
J Exp Med, 2004 May 05; 199(9). PMID: 15123743    Free PMC article.
Increased intratumoral IL-22-producing CD4(+) T cells and Th22 cells correlate with gastric cancer progression and predict poor patient survival.
Yuan Zhuang, Liu-Sheng Peng, +10 authors, Quan-Ming Zou.
Cancer Immunol Immunother, 2012 Apr 25; 61(11). PMID: 22527243
Effector T Cells Abrogate Stroma-Mediated Chemoresistance in Ovarian Cancer.
Weimin Wang, Ilona Kryczek, +18 authors, Weiping Zou.
Cell, 2016 May 03; 165(5). PMID: 27133165    Free PMC article.
Highly Cited.
Intertumor and intratumor NY-ESO-1 expression heterogeneity is associated with promoter-specific and global DNA methylation status in ovarian cancer.
Anna Woloszynska-Read, Paulette Mhawech-Fauceglia, +2 authors, Adam R Karpf.
Clin Cancer Res, 2008 Jun 04; 14(11). PMID: 18519754    Free PMC article.
CXCL17, an orphan chemokine, acts as a novel angiogenic and anti-inflammatory factor.
Wei-Yu Lee, Chun-Jen Wang, +2 authors, Ching-Wei Luo.
Am J Physiol Endocrinol Metab, 2012 Nov 02; 304(1). PMID: 23115081
IL-22(+)CD4(+) T cells promote colorectal cancer stemness via STAT3 transcription factor activation and induction of the methyltransferase DOT1L.
Ilona Kryczek, Yanwei Lin, +13 authors, Weiping Zou.
Immunity, 2014 May 13; 40(5). PMID: 24816405    Free PMC article.
Highly Cited.
Myeloid-derived suppressor cells enhance stemness of cancer cells by inducing microRNA101 and suppressing the corepressor CtBP2.
Tracy X Cui, Ilona Kryczek, +14 authors, Weiping Zou.
Immunity, 2013 Sep 10; 39(3). PMID: 24012420    Free PMC article.
Highly Cited.
Regulation of the chemokine receptor CXCR4 by hypoxia.
Tiziana Schioppa, Badarch Uranchimeg, +10 authors, Antonio Sica.
J Exp Med, 2003 Nov 05; 198(9). PMID: 14597738    Free PMC article.
Highly Cited.
CXCL14 expression and potential function in pancreatic cancer.
Moritz N Wente, Christine Mayer, +6 authors, Helmut Friess.
Cancer Lett, 2007 Dec 07; 259(2). PMID: 18054154
T cell anergy, exhaustion, senescence, and stemness in the tumor microenvironment.
Joel Crespo, Haoyu Sun, +2 authors, Weiping Zou.
Curr Opin Immunol, 2013 Jan 10; 25(2). PMID: 23298609    Free PMC article.
Highly Cited. Review.
Abrogation of TGF beta signaling in mammary carcinomas recruits Gr-1+CD11b+ myeloid cells that promote metastasis.
Li Yang, Jianhua Huang, +8 authors, Harold L Moses.
Cancer Cell, 2008 Jan 03; 13(1). PMID: 18167337    Free PMC article.
Highly Cited.
Chemokine receptor CXCR4 downregulated by von Hippel-Lindau tumour suppressor pVHL.
Peter Staller, Jitka Sulitkova, +3 authors, Wilhelm Krek.
Nature, 2003 Sep 19; 425(6955). PMID: 13679920
Highly Cited.
Intraepithelial CD8+ tumor-infiltrating lymphocytes and a high CD8+/regulatory T cell ratio are associated with favorable prognosis in ovarian cancer.
Eiichi Sato, Sara H Olson, +15 authors, Kunle Odunsi.
Proc Natl Acad Sci U S A, 2005 Dec 14; 102(51). PMID: 16344461    Free PMC article.
Highly Cited.
The IL-8-regulated chemokine receptor CXCR7 stimulates EGFR signaling to promote prostate cancer growth.
Rajendra Kumar Singh, Bal L Lokeshwar.
Cancer Res, 2011 Mar 15; 71(9). PMID: 21398406    Free PMC article.
Expression of CCR9 in HTLV-1+ T cells and ATL cells expressing Tax.
Daisuke Nagakubo, Zhe Jin, +8 authors, Osamu Yoshie.
Int J Cancer, 2007 Jan 06; 120(7). PMID: 17205512
Thymic stromal lymphopoietin fosters human breast tumor growth by promoting type 2 inflammation.
Alexander Pedroza-Gonzalez, Kangling Xu, +14 authors, A Karolina Palucka.
J Exp Med, 2011 Feb 23; 208(3). PMID: 21339324    Free PMC article.
Highly Cited.
Cancer and the chemokine network.
Fran Balkwill.
Nat Rev Cancer, 2004 Jul 02; 4(7). PMID: 15229479
Highly Cited. Review.
Macrophage inflammatory protein 3alpha transgene attracts dendritic cells to established murine tumors and suppresses tumor growth.
T Fushimi, A Kojima, M A Moore, R G Crystal.
J Clin Invest, 2000 May 17; 105(10). PMID: 10811846    Free PMC article.
Tim-3/galectin-9 signaling pathway mediates T-cell dysfunction and predicts poor prognosis in patients with hepatitis B virus-associated hepatocellular carcinoma.
Hang Li, Ke Wu, +8 authors, Weiping Zou.
Hepatology, 2012 Apr 17; 56(4). PMID: 22505239
Highly Cited.
Human interferon-inducible protein 10 is a potent inhibitor of angiogenesis in vivo.
A L Angiolillo, C Sgadari, +6 authors, G Tosato.
J Exp Med, 1995 Jul 01; 182(1). PMID: 7540647    Free PMC article.
Highly Cited.
Dendritic cell subsets differentially regulate angiogenesis in human ovarian cancer.
Tyler J Curiel, Pui Cheng, +10 authors, Weiping Zou.
Cancer Res, 2004 Aug 18; 64(16). PMID: 15313886
Regulatory T-cell compartmentalization and trafficking.
Shuang Wei, Ilona Kryczek, Weiping Zou.
Blood, 2006 Mar 16; 108(2). PMID: 16537800    Free PMC article.
Review.
Re-expression of CXCL14, a common target for epigenetic silencing in lung cancer, induces tumor necrosis.
M Tessema, D M Klinge, +3 authors, S A Belinsky.
Oncogene, 2010 Jun 22; 29(37). PMID: 20562917    Free PMC article.
A breast cancer stem cell niche supported by juxtacrine signalling from monocytes and macrophages.
Haihui Lu, Karl R Clauser, +8 authors, Robert A Weinberg.
Nat Cell Biol, 2014 Oct 01; 16(11). PMID: 25266422    Free PMC article.
Highly Cited.
Innate lymphoid cells sustain colon cancer through production of interleukin-22 in a mouse model.
Stefanie Kirchberger, Daniel J Royston, +5 authors, Fiona Powrie.
J Exp Med, 2013 Apr 17; 210(5). PMID: 23589566    Free PMC article.
Highly Cited.
Tumour hypoxia promotes tolerance and angiogenesis via CCL28 and T(reg) cells.
Andrea Facciabene, Xiaohui Peng, +8 authors, George Coukos.
Nature, 2011 Jul 15; 475(7355). PMID: 21753853
Highly Cited.
CCL18 from tumor-associated macrophages promotes breast cancer metastasis via PITPNM3.
Jingqi Chen, Yandan Yao, +14 authors, Erwei Song.
Cancer Cell, 2011 Apr 13; 19(4). PMID: 21481794    Free PMC article.
Highly Cited.
B cells promote tumor progression via STAT3 regulated-angiogenesis.
Chunmei Yang, Heehyoung Lee, +7 authors, Hua Yu.
PLoS One, 2013 Jun 05; 8(5). PMID: 23734190    Free PMC article.
IL-17+ regulatory T cells in the microenvironments of chronic inflammation and cancer.
Ilona Kryczek, Ke Wu, +11 authors, Weiping Zou.
J Immunol, 2011 Mar 02; 186(7). PMID: 21357259
Highly Cited.
Hypoxia-induced production of stromal cell-derived factor 1 (CXCL12) and vascular endothelial growth factor by synovial fibroblasts.
Carol Hitchon, Keng Wong, +3 authors, Hani El-Gabalawy.
Arthritis Rheum, 2002 Oct 18; 46(10). PMID: 12384916
Endogenous IL-17 contributes to reduced tumor growth and metastasis.
Ilona Kryczek, Shuang Wei, +2 authors, Weiping Zou.
Blood, 2009 Mar 18; 114(2). PMID: 19289853    Free PMC article.
Highly Cited.
CCL2 blockade augments cancer immunotherapy.
Zvi G Fridlender, George Buchlis, +9 authors, Steven M Albelda.
Cancer Res, 2009 Dec 24; 70(1). PMID: 20028856    Free PMC article.
Matrix metalloproteinases in tumor invasion and metastasis.
I Stamenkovic.
Semin Cancer Biol, 2001 Feb 15; 10(6). PMID: 11170864
Highly Cited. Review.
Regulation of expression of stromal-derived factor-1 receptors: CXCR4 and CXCR7 in human rhabdomyosarcomas.
Maciej Tarnowski, Katarzyna Grymula, +7 authors, Mariusz Z Ratajczak.
Mol Cancer Res, 2010 Jan 14; 8(1). PMID: 20068066    Free PMC article.
CXCL12 / CXCR4 / CXCR7 chemokine axis and cancer progression.
Xueqing Sun, Guangcun Cheng, +6 authors, Jianhua Wang.
Cancer Metastasis Rev, 2010 Sep 15; 29(4). PMID: 20839032    Free PMC article.
Highly Cited. Review.
Trafficking machinery of NKT cells: shared and differential chemokine receptor expression among V alpha 24(+)V beta 11(+) NKT cell subsets with distinct cytokine-producing capacity.
Chang H Kim, Brent Johnston, Eugene C Butcher.
Blood, 2002 Jun 19; 100(1). PMID: 12070001
B7-H1-expressing antigen-presenting cells mediate polarization of protumorigenic Th22 subsets.
Dong-Ming Kuang, Xiao Xiao, +10 authors, Limin Zheng.
J Clin Invest, 2014 Sep 23; 124(10). PMID: 25244097    Free PMC article.
CXCR7 heterodimerizes with CXCR4 and regulates CXCL12-mediated G protein signaling.
Angélique Levoye, Karl Balabanian, +2 authors, Bernard Lagane.
Blood, 2009 Apr 22; 113(24). PMID: 19380869
Highly Cited.
CCL25-CCR9 interaction modulates ovarian cancer cell migration, metalloproteinase expression, and invasion.
Erica L Johnson, Rajesh Singh, +4 authors, James W Lillard.
World J Surg Oncol, 2010 Jul 24; 8. PMID: 20649989    Free PMC article.
Molecular characterization of the tumor microenvironment in breast cancer.
Minna Allinen, Rameen Beroukhim, +10 authors, Kornelia Polyak.
Cancer Cell, 2004 Jul 21; 6(1). PMID: 15261139
Highly Cited.
Dendritic cells as therapeutic vaccines against cancer.
Jacques Banchereau, A Karolina Palucka.
Nat Rev Immunol, 2005 Apr 02; 5(4). PMID: 15803149
Highly Cited. Review.
Th22 cells control colon tumorigenesis through STAT3 and Polycomb Repression complex 2 signaling.
Danfeng Sun, Yanwei Lin, +8 authors, Weiping Zou.
Oncoimmunology, 2016 Sep 14; 5(8). PMID: 27622053    Free PMC article.
Faecalibacterium prausnitzii is an anti-inflammatory commensal bacterium identified by gut microbiota analysis of Crohn disease patients.
Harry Sokol, Bénédicte Pigneur, +17 authors, Philippe Langella.
Proc Natl Acad Sci U S A, 2008 Oct 22; 105(43). PMID: 18936492    Free PMC article.
Highly Cited.
CXCL12 and vascular endothelial growth factor synergistically induce neoangiogenesis in human ovarian cancers.
Ilona Kryczek, Andrzej Lange, +13 authors, Weiping Zou.
Cancer Res, 2005 Feb 08; 65(2). PMID: 15695388
Highly Cited.
Ineffectiveness of histone deacetylase inhibitors to induce apoptosis involves the transcriptional activation of NF-kappa B through the Akt pathway.
Marty W Mayo, Chadrick E Denlinger, +4 authors, David R Jones.
J Biol Chem, 2003 Mar 22; 278(21). PMID: 12649266
Breast cancer instructs dendritic cells to prime interleukin 13-secreting CD4+ T cells that facilitate tumor development.
Caroline Aspord, Alexander Pedroza-Gonzalez, +6 authors, A Karolina Palucka.
J Exp Med, 2007 Apr 18; 204(5). PMID: 17438063    Free PMC article.
Kupffer cell suppression of CD8+ T cells in human hepatocellular carcinoma is mediated by B7-H1/programmed death-1 interactions.
Ke Wu, Ilona Kryczek, +2 authors, Theodore H Welling.
Cancer Res, 2009 Oct 15; 69(20). PMID: 19826049    Free PMC article.
Highly Cited.
Functional activity of CXCL8 receptors, CXCR1 and CXCR2, on human malignant melanoma progression.
Chiara Gabellini, Daniela Trisciuoglio, +5 authors, Donatella Del Bufalo.
Eur J Cancer, 2009 Aug 18; 45(14). PMID: 19683430
The Role of the Chemokine System in Tissue Response to Prosthetic By-products Leading to Periprosthetic Osteolysis and Aseptic Loosening.
Tereza Dyskova, Jiri Gallo, Eva Kriegova.
Front Immunol, 2017 Sep 09; 8. PMID: 28883822    Free PMC article.
Review.
Interleukin 6 Present in Inflammatory Ascites from Advanced Epithelial Ovarian Cancer Patients Promotes Tumor Necrosis Factor Receptor 2-Expressing Regulatory T Cells.
Nirmala Chandralega Kampan, Mutsa Tatenda Madondo, +3 authors, Magdalena Plebanski.
Front Immunol, 2017 Nov 23; 8. PMID: 29163543    Free PMC article.
Melatonin attenuates hypoxia-induced epithelial-mesenchymal transition and cell aggressive via Smad7/ CCL20 in glioma.
Xueran Chen, Zhen Wang, +4 authors, Zhiyou Fang.
Oncotarget, 2017 Dec 08; 8(55). PMID: 29212174    Free PMC article.
C-C motif chemokine receptor 1 (CCR1) is a target of the EGF-AKT-mTOR-STAT3 signaling axis in breast cancer cells.
Soon Young Shin, Da Hyun Lee, +5 authors, Young Han Lee.
Oncotarget, 2017 Dec 08; 8(55). PMID: 29212252    Free PMC article.
Quantitative proteomic analysis of murine white adipose tissue for peritoneal cancer metastasis.
Peter E Feist, Elizabeth A Loughran, M Sharon Stack, Amanda B Hummon.
Anal Bioanal Chem, 2017 Dec 29; 410(5). PMID: 29282499    Free PMC article.
Prospects for chimeric antigen receptor-modified T cell therapy for solid tumors.
Erhao Zhang, Jieyi Gu, Hanmei Xu.
Mol Cancer, 2018 Jan 14; 17(1). PMID: 29329591    Free PMC article.
Review.
Agonist-induced CXCR4 and CB2 Heterodimerization Inhibits Gα13/RhoA-mediated Migration.
Kisha A Scarlett, El-Shaddai Z White, +3 authors, Cimona V Hinton.
Mol Cancer Res, 2018 Jan 14; 16(4). PMID: 29330286    Free PMC article.
Improving immune-vascular crosstalk for cancer immunotherapy.
Yuhui Huang, Betty Y S Kim, +3 authors, Wen Jiang.
Nat Rev Immunol, 2018 Jan 16; 18(3). PMID: 29332937    Free PMC article.
Highly Cited. Review.
Chemokines in homeostasis and diseases.
Keqiang Chen, Zhiyao Bao, +3 authors, Ji Ming Wang.
Cell Mol Immunol, 2018 Jan 30; 15(4). PMID: 29375126    Free PMC article.
Review.
Reverse of non-small cell lung cancer drug resistance induced by cancer-associated fibroblasts via a paracrine pathway.
Quanhui Zhang, Junping Yang, Jie Bai, Jianzhuang Ren.
Cancer Sci, 2018 Feb 01; 109(4). PMID: 29383798    Free PMC article.
Natural Immunomodulators.
D Ortuño-Sahagún, K Zänker, +2 authors, P Hegde.
J Immunol Res, 2018 Feb 02; 2017. PMID: 29387733    Free PMC article.
Mast cells as sources of cytokines, chemokines, and growth factors.
Kaori Mukai, Mindy Tsai, Hirohisa Saito, Stephen J Galli.
Immunol Rev, 2018 Feb 13; 282(1). PMID: 29431212    Free PMC article.
Highly Cited. Review.
Potentiating prostate cancer immunotherapy with oncolytic viruses.
Patrick Lee, Shashi Gujar.
Nat Rev Urol, 2018 Feb 13; 15(4). PMID: 29434366
Review.
Novel adherent CD11b+ Gr-1+ tumor-infiltrating cells initiate an immunosuppressive tumor microenvironment.
Takuya Tsubaki, Tetsuya Kadonosono, +8 authors, Shinae Kizaka-Kondoh.
Oncotarget, 2018 Mar 16; 9(13). PMID: 29541408    Free PMC article.
Phenotypic Plasticity, Bet-Hedging, and Androgen Independence in Prostate Cancer: Role of Non-Genetic Heterogeneity.
Mohit Kumar Jolly, Prakash Kulkarni, +2 authors, Herbert Levine.
Front Oncol, 2018 Mar 22; 8. PMID: 29560343    Free PMC article.
Highly Cited. Review.
Organ-specific metastasis of breast cancer: molecular and cellular mechanisms underlying lung metastasis.
Meysam Yousefi, Rahim Nosrati, +3 authors, Alihossein Saberi.
Cell Oncol (Dordr), 2018 Mar 24; 41(2). PMID: 29568985
Review.
Chemokines: the past, the present and the future.
Peng Tang, Ji Ming Wang.
Cell Mol Immunol, 2018 Mar 27; 15(4). PMID: 29578534    Free PMC article.
Pancreatic cancer therapy with combined mesothelin-redirected chimeric antigen receptor T cells and cytokine-armed oncolytic adenoviruses.
Keisuke Watanabe, Yanping Luo, +12 authors, Carl H June.
JCI Insight, 2018 Apr 06; 3(7). PMID: 29618658    Free PMC article.
Highly Cited.
Gastric cancer increases transmigratory potential of peripheral blood monocytes by upregulation of β1- and β2-integrins.
Andrzej Eljaszewicz, Michal Jankowski, +4 authors, Marcin Moniuszko.
Contemp Oncol (Pozn), 2018 Apr 10; 22(1A). PMID: 29628791    Free PMC article.
A guide to chemokines and their receptors.
Catherine E Hughes, Robert J B Nibbs.
FEBS J, 2018 Apr 11; 285(16). PMID: 29637711    Free PMC article.
Highly Cited. Review.
Inhibition of the CCL5/CCR5 Axis against the Progression of Gastric Cancer.
Donatella Aldinucci, Naike Casagrande.
Int J Mol Sci, 2018 May 19; 19(5). PMID: 29772686    Free PMC article.
Review.
Human Naive T Cells Express Functional CXCL8 and Promote Tumorigenesis.
Joel Crespo, Ke Wu, +6 authors, Weiping Zou.
J Immunol, 2018 May 29; 201(2). PMID: 29802127    Free PMC article.
Trial Watch: Immunostimulation with recombinant cytokines for cancer therapy.
Elena García-Martínez, Melody Smith, +10 authors, Lorenzo Galluzzi.
Oncoimmunology, 2018 Jun 07; 7(6). PMID: 29872569    Free PMC article.
Review.
Leukocyte-derived biomimetic nanoparticulate drug delivery systems for cancer therapy.
Yukun Huang, Xiaoling Gao, Jun Chen.
Acta Pharm Sin B, 2018 Jun 07; 8(1). PMID: 29872618    Free PMC article.
Review.
Clinicopathologic Significance of CXCL12 and CXCR4 Expressions in Patients with Colorectal Cancer.
Naomi Yoshuantari, Didik Setyo Heriyanto, +2 authors, Ahmad Ghozali.
Gastroenterol Res Pract, 2018 Jun 12; 2018. PMID: 29887884    Free PMC article.
Inactivation of CDK12 Delineates a Distinct Immunogenic Class of Advanced Prostate Cancer.
Yi-Mi Wu, Marcin Cieślik, +18 authors, Arul M Chinnaiyan.
Cell, 2018 Jun 16; 173(7). PMID: 29906450    Free PMC article.
Highly Cited.
Expression patterns of programmed death ligand 1 correlate with different microenvironments and patient prognosis in hepatocellular carcinoma.
Chao-Qun Liu, Jing Xu, +7 authors, Limin Zheng.
Br J Cancer, 2018 Jun 21; 119(1). PMID: 29921949    Free PMC article.
The novel long noncoding RNA u50535 promotes colorectal cancer growth and metastasis by regulating CCL20.
Xihu Yu, Zixu Yuan, +9 authors, Lei Wang.
Cell Death Dis, 2018 Jul 05; 9(7). PMID: 29970882    Free PMC article.
Influence of transcriptional variants on metastasis.
Joice De Faria Poloni, Diego Bonatto.
RNA Biol, 2018 Jul 10; 15(8). PMID: 29985094    Free PMC article.
Review.
CCL5-deficiency enhances intratumoral infiltration of CD8+ T cells in colorectal cancer.
Shengbo Zhang, Ming Zhong, +3 authors, Yan Zhang.
Cell Death Dis, 2018 Jul 12; 9(7). PMID: 29991744    Free PMC article.
The TGFα-EGFR-Akt signaling axis plays a role in enhancing proinflammatory chemokines in triple-negative breast cancer cells.
Rosa Mistica C Ignacio, Carla R Gibbs, Eun-Sook Lee, Deok-Soo Son.
Oncotarget, 2018 Jul 24; 9(50). PMID: 30034618    Free PMC article.
Immune Landscape of Colorectal Cancer Tumor Microenvironment from Different Primary Tumor Location.
Longhui Zhang, Yuetao Zhao, +6 authors, Bo Zhu.
Front Immunol, 2018 Jul 26; 9. PMID: 30042763    Free PMC article.
Highly Cited.
Superagonist IL-15-Armed Oncolytic Virus Elicits Potent Antitumor Immunity and Therapy That Are Enhanced with PD-1 Blockade.
Stacy J Kowalsky, Zuqiang Liu, +7 authors, David L Bartlett.
Mol Ther, 2018 Aug 02; 26(10). PMID: 30064894    Free PMC article.
IL-8/CXCR1/2 signalling promotes tumor cell proliferation, invasion and vascular mimicry in glioblastoma.
Ira Sharma, Avninder Singh, Fouzia Siraj, Sunita Saxena.
J Biomed Sci, 2018 Aug 09; 25(1). PMID: 30086759    Free PMC article.
NGAL promotes recruitment of tumor infiltrating leukocytes.
Francesco Pacifico, Luna Pisa, +3 authors, Antonio Leonardi.
Oncotarget, 2018 Aug 17; 9(56). PMID: 30112105    Free PMC article.
Chemokine Receptors and Exercise to Tackle the Inadequacy of T Cell Homing to the Tumor Site.
Manja Idorn, Per Thor Straten.
Cells, 2018 Aug 22; 7(8). PMID: 30126117    Free PMC article.
Review.
Role of mTOR Signaling in Tumor Microenvironment: An Overview.
Fabiana Conciatori, Chiara Bazzichetto, +5 authors, Ludovica Ciuffreda.
Int J Mol Sci, 2018 Aug 22; 19(8). PMID: 30126252    Free PMC article.
Highly Cited. Review.
Immunotherapeutic maintenance treatment with toll-like receptor 9 agonist lefitolimod in patients with extensive-stage small-cell lung cancer: results from the exploratory, controlled, randomized, international phase II IMPULSE study.
M Thomas, S Ponce-Aix, +13 authors, IMPULSE study team.
Ann Oncol, 2018 Aug 24; 29(10). PMID: 30137193    Free PMC article.
CCL17/TARC and CCR4 expression in Merkel cell carcinoma.
Kashif Rasheed, Ibrahim Abdulsalam, +3 authors, Ugo Moens.
Oncotarget, 2018 Aug 25; 9(59). PMID: 30140381    Free PMC article.
Capturing functional long non-coding RNAs through integrating large-scale causal relations from gene perturbation experiments.
Jinyuan Xu, Aiai Shi, +9 authors, Xia Li.
EBioMedicine, 2018 Sep 05; 35. PMID: 30177244    Free PMC article.
PET imaging of chemokine receptor CXCR4 in patients with primary and recurrent breast carcinoma.
Tibor Vag, Katja Steiger, +7 authors, Markus Schwaiger.
EJNMMI Res, 2018 Sep 08; 8(1). PMID: 30191351    Free PMC article.
Co-expression of sperm membrane proteins CMTM2A and CMTM2B is essential for ADAM3 localization and male fertility in mice.
Yoshitaka Fujihara, Asami Oji, +2 authors, Masahito Ikawa.
J Cell Sci, 2018 Sep 14; 131(19). PMID: 30209135    Free PMC article.
CXCR4 Based Therapeutics for Non-Small Cell Lung Cancer (NSCLC).
Ori Wald.
J Clin Med, 2018 Sep 28; 7(10). PMID: 30257500    Free PMC article.
Review.
Divergent Expression Patterns and Function of Two cxcr4 Paralogs in Hermaphroditic Epinephelus coioides.
Wei-Jia Lu, Li Zhou, +6 authors, Jian-Fang Gui.
Int J Mol Sci, 2018 Sep 29; 19(10). PMID: 30262794    Free PMC article.
Impact of chemotactic factors and receptors on the cancer immune infiltrate: a bioinformatics study revealing homogeneity and heterogeneity among patient cohorts.
Gautier Stoll, Jonathan Pol, +2 authors, Guido Kroemer.
Oncoimmunology, 2018 Oct 06; 7(10). PMID: 30288345    Free PMC article.
IL-6 augments IL-4-induced polarization of primary human macrophages through synergy of STAT3, STAT6 and BATF transcription factors.
Sahil Gupta, Arpit Jain, +8 authors, Dmitry Namgaladze.
Oncoimmunology, 2018 Oct 06; 7(10). PMID: 30288360    Free PMC article.
Chemokine Heterocomplexes and Cancer: A Novel Chapter to Be Written in Tumor Immunity.
Gianluca D'Agostino, Valentina Cecchinato, Mariagrazia Uguccioni.
Front Immunol, 2018 Oct 16; 9. PMID: 30319638    Free PMC article.
Review.
The Role of Type 1 Conventional Dendritic Cells in Cancer Immunity.
Jan P Böttcher, Caetano Reis e Sousa.
Trends Cancer, 2018 Oct 26; 4(11). PMID: 30352680    Free PMC article.
Highly Cited. Review.
Tumor stroma-infiltrating mast cells predict prognosis and adjuvant chemotherapeutic benefits in patients with muscle invasive bladder cancer.
Zheng Liu, Yu Zhu, +7 authors, Jiejie Xu.
Oncoimmunology, 2018 Nov 06; 7(9). PMID: 30393586    Free PMC article.
Modulation of the CCR6-CCL20 Axis: A Potential Therapeutic Target in Inflammation and Cancer.
Ranmali Ranasinghe, Rajaraman Eri.
Medicina (Kaunas), 2018 Nov 21; 54(5). PMID: 30453514    Free PMC article.
Review.
Breast Cancer Chemo-immunotherapy through Liposomal Delivery of an Immunogenic Cell Death Stimulus Plus Interference in the IDO-1 Pathway.
Jianqin Lu, Xiangsheng Liu, +6 authors, Andre E Nel.
ACS Nano, 2018 Nov 30; 12(11). PMID: 30481959    Free PMC article.
Targeting Macrophage-Recruiting Chemokines as a Novel Therapeutic Strategy to Prevent the Progression of Solid Tumors.
David Argyle, Takanori Kitamura.
Front Immunol, 2018 Nov 30; 9. PMID: 30483271    Free PMC article.
Review.
Neutrophils to lymphocytes ratio as a useful prognosticator for stage II colorectal cancer patients.
Nikoletta Dimitriou, Evangelos Felekouras, +3 authors, John Griniatsos.
BMC Cancer, 2018 Dec 05; 18(1). PMID: 30509242    Free PMC article.
miR-17-5p-CXCL14 axis related transcriptome profile and clinical outcome in diffuse gliomas.
Ailiang Zeng, Jianxin Yin, +5 authors, Yongping You.
Oncoimmunology, 2018 Dec 14; 7(12). PMID: 30524906    Free PMC article.
Tumor suppressor TET2 promotes cancer immunity and immunotherapy efficacy.
Yan-Ping Xu, Lei Lv, +8 authors, Yue Xiong.
J Clin Invest, 2019 Jul 17; 129(10). PMID: 31310587    Free PMC article.
CXCL12 expression in intrahepatic cholangiocarcinoma is associated with metastasis and poor prognosis.
Tatsunori Miyata, Yo-Ichi Yamashita, +6 authors, Hideo Baba.
Cancer Sci, 2019 Jul 31; 110(10). PMID: 31361379    Free PMC article.
An Autocrine Wnt5a Loop Promotes NF-κB Pathway Activation and Cytokine/Chemokine Secretion in Melanoma.
Gastón Barbero, María Victoria Castro, +4 authors, Pablo Lopez-Bergami.
Cells, 2019 Sep 13; 8(9). PMID: 31510045    Free PMC article.
Identification of new cancer stem cell markers and signaling pathways in HER‑2‑positive breast cancer by transcriptome sequencing.
Lu Feng, Shangke Huang, +3 authors, Xinhan Zhao.
Int J Oncol, 2019 Sep 24; 55(5). PMID: 31545416    Free PMC article.
lncRNA‑u50535 promotes the progression of lung cancer by activating CCL20/ERK signaling.
Wei Wei, Xiaoliang Zhao, +7 authors, Changli Wang.
Oncol Rep, 2019 Sep 24; 42(5). PMID: 31545478    Free PMC article.
NF-κB Dependent Chemokine Signaling in Pancreatic Cancer.
Claudia Geismann, Heiner Schäfer, +4 authors, Alexander Arlt.
Cancers (Basel), 2019 Sep 29; 11(10). PMID: 31561620    Free PMC article.
Review.
Deep Learning Implicitly Handles Tissue Specific Phenomena to Predict Tumor DNA Accessibility and Immune Activity.
Kamil Wnuk, Jeremi Sudol, +4 authors, Charles Vaske.
iScience, 2019 Sep 30; 20. PMID: 31563852    Free PMC article.
AURKB: a promising biomarker in clear cell renal cell carcinoma.
Bangbei Wan, Yuan Huang, +2 authors, Cai Lv.
PeerJ, 2019 Oct 03; 7. PMID: 31576249    Free PMC article.
The TLR7/8 agonist R848 remodels tumor and host responses to promote survival in pancreatic cancer.
Katherine A Michaelis, Mason A Norgard, +12 authors, Daniel L Marks.
Nat Commun, 2019 Oct 17; 10(1). PMID: 31615993    Free PMC article.
Fabrication Of Dual pH/redox-Responsive Lipid-Polymer Hybrid Nanoparticles For Anticancer Drug Delivery And Controlled Release.
Wanfu Men, Peiyao Zhu, +7 authors, Shuguang Zhang.
Int J Nanomedicine, 2019 Oct 22; 14. PMID: 31632014    Free PMC article.
Tailored Black Phosphorus for Erythrocyte Membrane Nanocloaking with Interleukin-1α siRNA and Paclitaxel for Targeted, Durable, and Mild Combination Cancer Therapy.
Wenquan Ou, Jeong Hoon Byeon, +7 authors, Jong Oh Kim.
Theranostics, 2019 Oct 30; 9(23). PMID: 31660068    Free PMC article.
Lipopolysaccharide-anchored macrophages hijack tumor microtube networks for selective drug transport and augmentation of antitumor effects in orthotopic lung cancer.
Ling Guo, Ye Zhang, +2 authors, Min Feng.
Theranostics, 2019 Oct 30; 9(23). PMID: 31660078    Free PMC article.
Small molecules as theranostic agents in cancer immunology.
Jindian Li, Juno Van Valkenburgh, +3 authors, Kai Chen.
Theranostics, 2019 Nov 07; 9(25). PMID: 31695804    Free PMC article.
Review.
Beneficial modulation of the tumor microenvironment and generation of anti-tumor responses by TLR9 agonist lefitolimod alone and in combination with checkpoint inhibitors.
Kerstin Kapp, Barbara Volz, +3 authors, Manuel Schmidt.
Oncoimmunology, 2019 Nov 20; 8(12). PMID: 31741757    Free PMC article.
Bone marrow expands the repertoire of functional T cells targeting tumor-associated antigens in patients with resectable non-small-cell lung cancer.
Seyer Safi, Yoshikane Yamauchi, +11 authors, Philipp Beckhove.
Oncoimmunology, 2019 Nov 20; 8(12). PMID: 31741774    Free PMC article.
Tissue-specific tumor microenvironments influence responses to immunotherapies.
Amanda J Oliver, Ashleigh S Davey, +9 authors, Clare Y Slaney.
Clin Transl Immunology, 2019 Nov 27; 8(11). PMID: 31768254    Free PMC article.
Tumor Characterization in Breast Cancer Identifies Immune-Relevant Gene Signatures Associated With Prognosis.
Jie Li, Cun Liu, +7 authors, Changgang Sun.
Front Genet, 2019 Nov 30; 10. PMID: 31781173    Free PMC article.
Transcriptome analysis of dog oral melanoma and its oncogenic analogy with human melanoma.
Md Mahfuzur Rahman, Yu-Chang Lai, +8 authors, Naoki Miura.
Oncol Rep, 2019 Oct 30; 43(1). PMID: 31661138    Free PMC article.
Recruitment of CD103+ dendritic cells via tumor-targeted chemokine delivery enhances efficacy of checkpoint inhibitor immunotherapy.
John-Michael Williford, Jun Ishihara, +6 authors, Jeffrey A Hubbell.
Sci Adv, 2019 Dec 18; 5(12). PMID: 31844672    Free PMC article.
Proteolytic chemokine cleavage as a regulator of lymphocytic infiltration in solid tumors.
Holger Bronger, Viktor Magdolen, Peter Goettig, Tobias Dreyer.
Cancer Metastasis Rev, 2019 Sep 05; 38(3). PMID: 31482487    Free PMC article.
Review.
Receptor-Interacting Protein Kinase 3 Deficiency Recruits Myeloid-Derived Suppressor Cells to Hepatocellular Carcinoma Through the Chemokine (C-X-C Motif) Ligand 1-Chemokine (C-X-C Motif) Receptor 2 Axis.
Yi-Ming Li, Zhen-Yu Liu, +5 authors, Zhi-Nan Chen.
Hepatology, 2019 Apr 26; 70(5). PMID: 31021443    Free PMC article.
Phosphodiesterase 5 (PDE5) Is Highly Expressed in Cancer-Associated Fibroblasts and Enhances Breast Tumor Progression.
Stefania Catalano, Salvatore Panza, +9 authors, Ines Barone.
Cancers (Basel), 2019 Nov 09; 11(11). PMID: 31698786    Free PMC article.
Transforming Growth Factor-β Signaling Pathway in Colorectal Cancer and Its Tumor Microenvironment.
Yoshiro Itatani, Kenji Kawada, Yoshiharu Sakai.
Int J Mol Sci, 2019 Nov 24; 20(23). PMID: 31756952    Free PMC article.
Review.
Identification of Key Genes in Thyroid Cancer Microenvironment.
Kankan Zhao, Hao Yang, Houlong Kang, Aiguo Wu.
Med Sci Monit, 2019 Dec 17; 25. PMID: 31839674    Free PMC article.
The combination of CXCL9, CXCL10 and CXCL11 levels during primary HIV infection predicts HIV disease progression.
Xiaowan Yin, Zhuo Wang, +9 authors, Yongjun Jiang.
J Transl Med, 2019 Dec 15; 17(1). PMID: 31836011    Free PMC article.
Targeting the STING pathway in tumor-associated macrophages regulates innate immune sensing of gastric cancer cells.
Lei Miao, Jingjing Qi, +9 authors, Rui-Hua Xu.
Theranostics, 2020 Jan 07; 10(2). PMID: 31903134    Free PMC article.
Genetic Programs Driving Oncogenic Transformation: Lessons from in Vitro Models.
Eros Di Giorgio, Harikrishnareddy Paluvai, Raffaella Picco, Claudio Brancolini.
Int J Mol Sci, 2019 Dec 18; 20(24). PMID: 31842516    Free PMC article.
PTPN2 phosphatase deletion in T cells promotes anti-tumour immunity and CAR T-cell efficacy in solid tumours.
Florian Wiede, Kun-Hui Lu, +16 authors, Tony Tiganis.
EMBO J, 2019 Dec 06; 39(2). PMID: 31803974    Free PMC article.
Identifying Predictive Factors of Recurrence after Radical Resection in Gastric Cancer by RNA Immune-oncology Panel.
Yuehong Cui, Shan Yu, +10 authors, Tianshu Liu.
J Cancer, 2020 Jan 17; 11(3). PMID: 31942187    Free PMC article.
CXCL9 chemokine promotes the progression of human pancreatic adenocarcinoma through STAT3-dependent cytotoxic T lymphocyte suppression.
Hui-Feng Gao, Chien-Shan Cheng, +5 authors, Lian-Yu Chen.
Aging (Albany NY), 2020 Jan 09; 12(1). PMID: 31913856    Free PMC article.
CCL14 is a prognostic biomarker and correlates with immune infiltrates in hepatocellular carcinoma.
Yurong Gu, Xiangyong Li, +7 authors, Yuehua Huang.
Aging (Albany NY), 2020 Jan 14; 12(1). PMID: 31927532    Free PMC article.
Identification of Distinct Immune Subtypes in Colorectal Cancer Based on the Stromal Compartment.
Rongfang Shen, Ping Li, +3 authors, Shujun Cheng.
Front Oncol, 2020 Jan 31; 9. PMID: 31998649    Free PMC article.
Chimeric Antigen Receptor T Cell Therapy: A Novel Modality for Immune Modulation.
Somy Yoon, Gwang Hyeon Eom.
Chonnam Med J, 2020 Feb 06; 56(1). PMID: 32021836    Free PMC article.
Review.
A TLR7 agonist strengthens T and NK cell function during BRAF-targeted therapy in a preclinical melanoma model.
Lydia Bellmann, Giuseppe Cappellano, +7 authors, Patrizia Stoitzner.
Int J Cancer, 2019 Nov 09; 146(5). PMID: 31702822    Free PMC article.
Intratumoral delivery of CCL25 enhances immunotherapy against triple-negative breast cancer by recruiting CCR9+ T cells.
Hongmei Chen, Xiuxiu Cong, +16 authors, Tianmeng Sun.
Sci Adv, 2020 Feb 18; 6(5). PMID: 32064335    Free PMC article.
Pre-operative sera interleukin-6 in the diagnosis of high-grade serous ovarian cancer.
Nirmala Chandralega Kampan, Mutsa Tatenda Madondo, +6 authors, Magdalena Plebanski.
Sci Rep, 2020 Feb 12; 10(1). PMID: 32042020    Free PMC article.
Checkpoint molecules coordinately restrain hyperactivated effector T cells in the tumor microenvironment.
Min Yang, Wenwen Du, +9 authors, Binfeng Lu.
Oncoimmunology, 2020 Feb 23; 9(1). PMID: 32076578    Free PMC article.
Modulation of the immune microenvironment by tumor-intrinsic oncogenic signaling.
Kim Bich Nguyen, Stefani Spranger.
J Cell Biol, 2019 Dec 10; 219(1). PMID: 31816057    Free PMC article.
Review.
Schistosoma mansoni PCR+ -infected individuals in the Sudan present elevated systemic levels of chemokines when compared to uninfected and egg+ cohorts.
K Arndts, T E M Elfaki, +8 authors, L E Layland.
Clin Exp Immunol, 2019 Feb 07; 196(3). PMID: 30724349    Free PMC article.
Illuminating the Onco-GPCRome: Novel G protein-coupled receptor-driven oncocrine networks and targets for cancer immunotherapy.
Victoria Wu, Huwate Yeerna, +7 authors, J Silvio Gutkind.
J Biol Chem, 2019 Jun 07; 294(29). PMID: 31171722    Free PMC article.
Review.
Identification of Therapeutic Targets and Prognostic Biomarkers Among CXC Chemokines in the Renal Cell Carcinoma Microenvironment.
Qingquan Zeng, Shuolei Sun, +3 authors, Hao Liang.
Front Oncol, 2020 Mar 03; 9. PMID: 32117786    Free PMC article.
CCL5-armed oncolytic virus augments CCR5-engineered NK cell infiltration and antitumor efficiency.
Feng Li, Yuqiao Sheng, +4 authors, Yi Zhang.
J Immunother Cancer, 2020 Feb 27; 8(1). PMID: 32098828    Free PMC article.
Inhibition of histone lysine-specific demethylase 1 elicits breast tumor immunity and enhances antitumor efficacy of immune checkpoint blockade.
Ye Qin, Shauna N Vasilatos, +9 authors, Yi Huang.
Oncogene, 2018 Aug 17; 38(3). PMID: 30111819    Free PMC article.
Insights into Pathogenic Interactions Among Environment, Host, and Tumor at the Crossroads of Molecular Pathology and Epidemiology.
Shuji Ogino, Jonathan A Nowak, +2 authors, Reiko Nishihara.
Annu Rev Pathol, 2018 Aug 21; 14. PMID: 30125150    Free PMC article.
Highly Cited. Review.
EnanDIM - a novel family of L-nucleotide-protected TLR9 agonists for cancer immunotherapy.
Kerstin Kapp, Barbara Volz, +3 authors, Manuel Schmidt.
J Immunother Cancer, 2019 Jan 10; 7(1). PMID: 30621769    Free PMC article.
Engineering Nanoparticles for Targeted Remodeling of the Tumor Microenvironment to Improve Cancer Immunotherapy.
Shan Gao, Dongjuan Yang, +6 authors, Kai Shi.
Theranostics, 2019 Jan 22; 9(1). PMID: 30662558    Free PMC article.
Highly Cited. Review.
Development and validation of nomograms integrating immune-related genomic signatures with clinicopathologic features to improve prognosis and predictive value of triple-negative breast cancer: A gene expression-based retrospective study.
Kang Wang, Hai-Lin Li, +5 authors, Hong-Yuan Li.
Cancer Med, 2019 Jan 25; 8(2). PMID: 30677255    Free PMC article.
Axl kinase drives immune checkpoint and chemokine signalling pathways in lung adenocarcinomas.
Yoko Tsukita, Naoya Fujino, +11 authors, Masakazu Ichinose.
Mol Cancer, 2019 Feb 13; 18(1). PMID: 30744655    Free PMC article.
Support of Tumor Endothelial Cells by Chemokine Receptors.
Nicole Salazar, Brian A Zabel.
Front Immunol, 2019 Feb 26; 10. PMID: 30800123    Free PMC article.
Review.
Cryo-thermal therapy induces macrophage polarization for durable anti-tumor immunity.
Kun He, Shengguo Jia, +2 authors, Lisa X Xu.
Cell Death Dis, 2019 Mar 06; 10(3). PMID: 30833570    Free PMC article.
Are innovation and new technologies in precision medicine paving a new era in patients centric care?
Attila A Seyhan, Claudio Carini.
J Transl Med, 2019 Apr 07; 17(1). PMID: 30953518    Free PMC article.
Review.
The role of extracellular vesicles from different origin in the microenvironment of head and neck cancers.
Changqing Xie, Ning Ji, +2 authors, Qianming Chen.
Mol Cancer, 2019 Apr 08; 18(1). PMID: 30954079    Free PMC article.
Review.
Tracking Biodistribution of Myeloid-Derived Cells in Murine Models of Breast Cancer.
Jun Li, Junhua Mai, +8 authors, Haifa Shen.
Genes (Basel), 2019 Apr 25; 10(4). PMID: 31013756    Free PMC article.
Fast and robust deconvolution of tumor infiltrating lymphocyte from expression profiles using least trimmed squares.
Yuning Hao, Ming Yan, +2 authors, Yuying Xie.
PLoS Comput Biol, 2019 May 07; 15(5). PMID: 31059559    Free PMC article.
Induced Pluripotent Stem Cell-Derived T Cells for Cancer Immunotherapy.
Sunny J Patel, Takayoshi Yamauchi, Fumito Ito.
Surg Oncol Clin N Am, 2019 May 14; 28(3). PMID: 31079802    Free PMC article.
Review.
M2 macrophages promote NSCLC metastasis by upregulating CRYAB.
Zhe Guo, Jing Song, +8 authors, Qi Wang.
Cell Death Dis, 2019 May 18; 10(6). PMID: 31097690    Free PMC article.
Phosphoinositide 3-kinase δ is a regulatory T-cell target in cancer immunotherapy.
Ee Lyn Lim, Klaus Okkenhaug.
Immunology, 2019 May 21; 157(3). PMID: 31107985    Free PMC article.
Review.
Molecular and pharmacological modulators of the tumor immune contexture revealed by deconvolution of RNA-seq data.
Francesca Finotello, Clemens Mayer, +20 authors, Zlatko Trajanoski.
Genome Med, 2019 May 28; 11(1). PMID: 31126321    Free PMC article.
Highly Cited.
LIF regulates CXCL9 in tumor-associated macrophages and prevents CD8+ T cell tumor-infiltration impairing anti-PD1 therapy.
Mónica Pascual-García, Ester Bonfill-Teixidor, +21 authors, Joan Seoane.
Nat Commun, 2019 Jun 13; 10(1). PMID: 31186412    Free PMC article.
The Distinct Roles of CXCR3 Variants and Their Ligands in the Tumor Microenvironment.
Nathan Reynders, Dayana Abboud, +8 authors, Andy Chevigné.
Cells, 2019 Jun 21; 8(6). PMID: 31216755    Free PMC article.
Review.
Combination Radioimmunotherapy Strategies for Solid Tumors.
Javeria Zaheer, Hyeongi Kim, +2 authors, Sang Moo Lim.
Int J Mol Sci, 2019 Nov 14; 20(22). PMID: 31717302    Free PMC article.
Review.
Mechanisms of Tumor-Lymphatic Interactions in Invasive Breast and Prostate Carcinoma.
Leticia Oliveira-Ferrer, Karin Milde-Langosch, +6 authors, Walter Fiedler.
Int J Mol Sci, 2020 Jan 23; 21(2). PMID: 31963450    Free PMC article.
A positive feedback loop of β-catenin/CCR2 axis promotes regorafenib resistance in colorectal cancer.
Baochi Ou, Xi Cheng, +4 authors, Aiguo Lu.
Cell Death Dis, 2019 Sep 11; 10(9). PMID: 31501414    Free PMC article.
Chemokines and their Receptors: Multifaceted Roles in Cancer Progression and Potential Value as Cancer Prognostic Markers.
Ha Thi Thu Do, Chang Hoon Lee, Jungsook Cho.
Cancers (Basel), 2020 Jan 30; 12(2). PMID: 31991604    Free PMC article.
Review.
Tumors Provoke Inflammation and Perineural Microlesions at Adjacent Peripheral Nerves.
Jennifer Cohnen, Lisa Kornstädt, +6 authors, Klaus Scholich.
Cells, 2020 Feb 06; 9(2). PMID: 32013137    Free PMC article.
The Impact of Focused Ultrasound in Two Tumor Models: Temporal Alterations in the Natural History on Tumor Microenvironment and Immune Cell Response.
Gadi Cohen, Parwathy Chandran, +4 authors, Joseph A Frank.
Cancers (Basel), 2020 Feb 09; 12(2). PMID: 32033171    Free PMC article.
Chemokines-What Is Their Role in Colorectal Cancer?
Sara Pączek, Marta Łukaszewicz-Zając, Barbara Mroczko.
Cancer Control, 2020 Feb 28; 27(1). PMID: 32103675    Free PMC article.
Targeting CAMKII to reprogram tumor-associated macrophages and inhibit tumor cells for cancer immunotherapy with an injectable hybrid peptide hydrogel.
Xiaomeng Dai, Jingshu Meng, +11 authors, Honglin Jin.
Theranostics, 2020 Mar 21; 10(7). PMID: 32194854    Free PMC article.
Cancer-associated fibroblasts: an emerging target of anti-cancer immunotherapy.
Tongyan Liu, Chencheng Han, +4 authors, Rong Yin.
J Hematol Oncol, 2019 Aug 30; 12(1). PMID: 31462327    Free PMC article.
Highly Cited. Review.
In silico analysis of the immune microenvironment in bladder cancer.
Ye Zhang, De-Hua Ou, +2 authors, Ming-En Lin.
BMC Cancer, 2020 Apr 02; 20(1). PMID: 32228629    Free PMC article.
Transcriptomic features of tumour-infiltrating CD4lowCD8high double positive αβ T cells in melanoma.
Tiphaine Parrot, Romain Oger, +10 authors, Nadine Gervois.
Sci Rep, 2020 Apr 05; 10(1). PMID: 32246006    Free PMC article.
The Ins and Outs of Chemokine-Mediated Immune Cell Trafficking in Skin Cancer.
Andrew O Yam, Tatyana Chtanova.
Front Immunol, 2019 Mar 23; 10. PMID: 30899263    Free PMC article.
Review.
Optimization of Organotypic Cultures of Mouse Spleen for Staining and Functional Assays.
Francesca Finetti, Nagaja Capitani, +7 authors, Laura Patrussi.
Front Immunol, 2020 Apr 09; 11. PMID: 32265925    Free PMC article.
Chemokines Modulate Immune Surveillance in Tumorigenesis, Metastasis, and Response to Immunotherapy.
Anna E Vilgelm, Ann Richmond.
Front Immunol, 2019 Mar 16; 10. PMID: 30873179    Free PMC article.
Highly Cited. Review.
High-Throughput Microfluidic 3D Cytotoxicity Assay for Cancer Immunotherapy (CACI-IMPACT Platform).
Dohyun Park, Kyungmin Son, +4 authors, Noo Li Jeon.
Front Immunol, 2019 Jun 14; 10. PMID: 31191524    Free PMC article.
The Interplay Between Lymphatic Vessels and Chemokines.
Rae H Farnsworth, Tara Karnezis, +2 authors, Steven A Stacker.
Front Immunol, 2019 May 21; 10. PMID: 31105685    Free PMC article.
Review.
Endometrial Tumor Microenvironment Alters Human NK Cell Recruitment, and Resident NK Cell Phenotype and Function.
Clara Degos, Mellie Heinemann, +5 authors, Daniel Olive.
Front Immunol, 2019 May 21; 10. PMID: 31105699    Free PMC article.
The Endless Saga of Monocyte Diversity.
Stefania Canè, Stefano Ugel, +4 authors, Vincenzo Bronte.
Front Immunol, 2019 Aug 27; 10. PMID: 31447834    Free PMC article.
Review.
The Diagnostic Value of Chemokine/Chemokine Receptor Pairs in Hepatocellular Carcinoma and Colorectal Liver Metastasis.
Xiaolei Jiao, Guiming Shu, +9 authors, Yingtang Gao.
J Histochem Cytochem, 2019 Jan 12; 67(5). PMID: 30633620    Free PMC article.
Crosstalk between cancer and immune cells: Role of tumor-associated macrophages in the tumor microenvironment.
Jing Wang, Danyang Li, Huaixing Cang, Bo Guo.
Cancer Med, 2019 Jun 22; 8(10). PMID: 31222971    Free PMC article.
Highly Cited. Review.
NAD-Biosynthetic and Consuming Enzymes as Central Players of Metabolic Regulation of Innate and Adaptive Immune Responses in Cancer.
Valentina Audrito, Antonella Managò, +4 authors, Silvia Deaglio.
Front Immunol, 2019 Aug 14; 10. PMID: 31402913    Free PMC article.
Review.
Role of inflammasome activation in tumor immunity triggered by immune checkpoint blockers.
M Segovia, S Russo, +2 authors, M Hill.
Clin Exp Immunol, 2020 Apr 17; 200(2). PMID: 32297328    Free PMC article.
Review.
Serum-derived factors of breast cancer patients with brain metastases alter permeability of a human blood-brain barrier model.
Carolin J Curtaz, Constanze Schmitt, +8 authors, Malgorzata Burek.
Fluids Barriers CNS, 2020 Apr 24; 17(1). PMID: 32321535    Free PMC article.
Using apelin-based synthetic Notch receptors to detect angiogenesis and treat solid tumors.
Zhifu Wang, Fan Wang, +10 authors, Jianhong Zhu.
Nat Commun, 2020 May 03; 11(1). PMID: 32358530    Free PMC article.
Cav-1 Ablation in Pancreatic Stellate Cells Promotes Pancreatic Cancer Growth through Nrf2-Induced shh Signaling.
Shan Shao, Tao Qin, +9 authors, Jianjun Lei.
Oxid Med Cell Longev, 2020 May 08; 2020. PMID: 32377291    Free PMC article.
Loss of BAP1 expression is associated with an immunosuppressive microenvironment in uveal melanoma, with implications for immunotherapy development.
Carlos R Figueiredo, Helen Kalirai, +5 authors, Sarah E Coupland.
J Pathol, 2020 Jan 22; 250(4). PMID: 31960425    Free PMC article.
Engineering strategies to overcome the current roadblocks in CAR T cell therapy.
Sarwish Rafiq, Christopher S Hackett, Renier J Brentjens.
Nat Rev Clin Oncol, 2019 Dec 19; 17(3). PMID: 31848460    Free PMC article.
Highly Cited. Review.
A Targeted Multi-omic Analysis Approach Measures Protein Expression and Low-Abundance Transcripts on the Single-Cell Level.
Florian Mair, Jami R Erickson, +7 authors, Martin Prlic.
Cell Rep, 2020 Apr 09; 31(1). PMID: 32268080    Free PMC article.
The Role of CCL21/CCR7 Chemokine Axis in Breast Cancer Progression.
Balsam Rizeq, Mohammed Imad Malki.
Cancers (Basel), 2020 Apr 29; 12(4). PMID: 32340161    Free PMC article.
Review.
Inducers, Attractors and Modulators of CD4+ Treg Cells in Non-Small-Cell Lung Cancer.
Mengxiao Xie, Jia Wei, Jian Xu.
Front Immunol, 2020 May 20; 11. PMID: 32425930    Free PMC article.
Review.
CXCL13 and Its Receptor CXCR5 in Cancer: Inflammation, Immune Response, and Beyond.
Marcelo G Kazanietz, Michael Durando, Mariana Cooke.
Front Endocrinol (Lausanne), 2019 Jul 30; 10. PMID: 31354634    Free PMC article.
Review.
Characterization of tumour-infiltrating lymphocytes in a tumour rejection cynomolgus macaque model.
Hiroki Satooka, Hirohito Ishigaki, +5 authors, Takako Hirata.
Sci Rep, 2020 May 23; 10(1). PMID: 32439888    Free PMC article.
Serological Markers Associated With Response to Immune Checkpoint Blockade in Metastatic Gastrointestinal Tract Cancer.
Zhihao Lu, Jianling Zou, +17 authors, Lin Shen.
JAMA Netw Open, 2019 Jul 25; 2(7). PMID: 31339548    Free PMC article.
Diagnostic value of 18F-FDG-PET to predict the tumour immune status defined by tumoural PD-L1 and CD8+tumour-infiltrating lymphocytes in oral squamous cell carcinoma.
Maria Togo, Takehiko Yokobori, +8 authors, Tetsunari Oyama.
Br J Cancer, 2020 Apr 03; 122(11). PMID: 32238919    Free PMC article.
Entry and exit of chemotherapeutically-promoted cellular dormancy in glioblastoma cells is differentially affected by the chemokines CXCL12, CXCL16, and CX3CL1.
Vivian Adamski, Kirsten Hattermann, +5 authors, Janka Held-Feindt.
Oncogene, 2020 Apr 30; 39(22). PMID: 32346064    Free PMC article.
Inhibition of Vps34 reprograms cold into hot inflamed tumors and improves anti-PD-1/PD-L1 immunotherapy.
Muhammad Zaeem Noman, Santiago Parpal, +10 authors, Bassam Janji.
Sci Adv, 2020 Jun 05; 6(18). PMID: 32494661    Free PMC article.
Role of CC Chemokines Subfamily in the Platinum Drugs Resistance Promotion in Cancer.
Maria E Reyes, Marjorie de La Fuente, +2 authors, Priscilla Brebi.
Front Immunol, 2020 Jun 06; 11. PMID: 32499779    Free PMC article.
Review.
LUM Expression and Its Prognostic Significance in Gastric Cancer.
Xiaowei Chen, Xin Li, +6 authors, Xiaobing Shen.
Front Oncol, 2020 Jun 06; 10. PMID: 32500021    Free PMC article.
CCL2/CCR2 signaling in cancer pathogenesis.
Qiongyu Hao, Jaydutt V Vadgama, Piwen Wang.
Cell Commun Signal, 2020 May 31; 18(1). PMID: 32471499    Free PMC article.
Review.
The multifarious roles of the chemokine CXCL14 in cancer progression and immune responses.
Joseph A Westrich, Daniel W Vermeer, +2 authors, Dohun Pyeon.
Mol Carcinog, 2020 Mar 27; 59(7). PMID: 32212206    Free PMC article.
Review.
Chemokines and chemokine receptors: A new strategy for breast cancer therapy.
Hui Liu, Zhenjiang Yang, +6 authors, Yu Cai.
Cancer Med, 2020 Apr 08; 9(11). PMID: 32253815    Free PMC article.
Review.
Hypoxia regulates the differentiation and anti-tumor effector functions of γδT cells in oral cancer.
S K Sureshbabu, D Chaukar, S V Chiplunkar.
Clin Exp Immunol, 2020 Apr 08; 201(1). PMID: 32255193    Free PMC article.
Tumor Cell-Derived IL1β Promotes Desmoplasia and Immune Suppression in Pancreatic Cancer.
Shipra Das, Beny Shapiro, +2 authors, Dafna Bar-Sagi.
Cancer Res, 2020 Jan 10; 80(5). PMID: 31915130    Free PMC article.
Significance of Tumor-Infiltrating Immune Cells in the Prognosis of Colon Cancer.
Dejun Wu, Yue Ding, +4 authors, Ming Xu.
Onco Targets Ther, 2020 Jun 18; 13. PMID: 32547088    Free PMC article.
CXCR3 Ligands in Cancer and Autoimmunity, Chemoattraction of Effector T Cells, and Beyond.
Nathan Karin.
Front Immunol, 2020 Jun 18; 11. PMID: 32547545    Free PMC article.
Review.
Long-distance modulation of bystander tumor cells by CD8+ T cell-secreted IFNγ.
Mirjam E Hoekstra, Laura Bornes, +6 authors, Ton N M Schumacher.
Nat Cancer, 2020 Jun 23; 1(3). PMID: 32566933    Free PMC article.
Functional Role of Dendritic Cell Subsets in Cancer Progression and Clinical Implications.
Annalisa Del Prete, Francesca Sozio, +7 authors, Silvano Sozzani.
Int J Mol Sci, 2020 Jun 04; 21(11). PMID: 32486257    Free PMC article.
Review.
Chronic circadian disruption modulates breast cancer stemness and immune microenvironment to drive metastasis in mice.
Eva Hadadi, William Taylor, +10 authors, Hervé Acloque.
Nat Commun, 2020 Jun 26; 11(1). PMID: 32581213    Free PMC article.
Increased Expression of T-Box Transcription Factor Protein 21 (TBX21) in Skin Cutaneous Melanoma Predicts Better Prognosis: A Study Based on The Cancer Genome Atlas (TCGA) and Genotype-Tissue Expression (GTEx) Databases.
Xingying Zhang, Xin Wen, +4 authors, Longzhen Zhang.
Med Sci Monit, 2020 Jun 21; 26. PMID: 32561704    Free PMC article.
Molecular profiling of stroma highlights stratifin as a novel biomarker of poor prognosis in pancreatic ductal adenocarcinoma.
Fabien Robin, Gaëlle Angenard, +8 authors, Laurent Sulpice.
Br J Cancer, 2020 May 08; 123(1). PMID: 32376891    Free PMC article.
CXCL5 promotes gastric cancer metastasis by inducing epithelial-mesenchymal transition and activating neutrophils.
Zheying Mao, Jiahui Zhang, +7 authors, Xu Zhang.
Oncogenesis, 2020 Jul 08; 9(7). PMID: 32632106    Free PMC article.
Absence of central tolerance in Aire-deficient mice synergizes with immune-checkpoint inhibition to enhance antitumor responses.
Asiel A Benitez, Sara Khalil-Agüero, +6 authors, Sokol Haxhinasto.
Commun Biol, 2020 Jul 10; 3(1). PMID: 32641748    Free PMC article.
CCL18-NIR1 promotes oral cancer cell growth and metastasis by activating the JAK2/STAT3 signaling pathway.
Xiao Jiang, Zhijie Huang, +8 authors, Jianjiang Zhao.
BMC Cancer, 2020 Jul 10; 20(1). PMID: 32641093    Free PMC article.
Engineering Strategies to Enhance TCR-Based Adoptive T Cell Therapy.
Jan A Rath, Caroline Arber.
Cells, 2020 Jun 24; 9(6). PMID: 32570906    Free PMC article.
Review.
Cytokines and Chemokines as Mediators of Prostate Cancer Metastasis.
Timothy O Adekoya, Ricardo M Richardson.
Int J Mol Sci, 2020 Jun 27; 21(12). PMID: 32585812    Free PMC article.
Review.
Tumor Immune Microenvironment Clusters in Localized Prostate Adenocarcinoma: Prognostic Impact of Macrophage Enriched/Plasma Cell Non-Enriched Subtypes.
Neil K Jairath, Mark W Farha, +10 authors, Daniel E Spratt.
J Clin Med, 2020 Jul 01; 9(6). PMID: 32599760    Free PMC article.
The interplay between innate and adaptive immunity in cancer shapes the productivity of cancer immunosurveillance.
Renee B Chang, Gregory L Beatty.
J Leukoc Biol, 2020 Apr 10; 108(1). PMID: 32272502    Free PMC article.
Review.
Estrogen receptor α promotes lung cancer cell invasion via increase of and cross-talk with infiltrated macrophages through the CCL2/CCR2/MMP9 and CXCL12/CXCR4 signaling pathways.
Miao He, Weiwei Yu, +4 authors, Shuyuan Yeh.
Mol Oncol, 2020 May 02; 14(8). PMID: 32356397    Free PMC article.
The Adenosine System at the Crossroads of Intestinal Inflammation and Neoplasia.
Vanessa D'Antongiovanni, Matteo Fornai, +3 authors, Luca Antonioli.
Int J Mol Sci, 2020 Jul 28; 21(14). PMID: 32708507    Free PMC article.
Review.
CXCL14 Maintains hESC Self-Renewal through Binding to IGF-1R and Activation of the IGF-1R Pathway.
Chih-Lun Cheng, Shang-Chih Yang, +9 authors, Jean Lu.
Cells, 2020 Jul 28; 9(7). PMID: 32708730    Free PMC article.
EN2 as an oncogene promotes tumor progression via regulating CCL20 in colorectal cancer.
Yimin Li, Jiaxin Liu, +6 authors, Gang Yin.
Cell Death Dis, 2020 Aug 01; 11(7). PMID: 32732864    Free PMC article.
The CCL20-CCR6 Axis in Cancer Progression.
Suguru Kadomoto, Kouji Izumi, Atsushi Mizokami.
Int J Mol Sci, 2020 Jul 28; 21(15). PMID: 32707869    Free PMC article.
Review.
Brain microenvironment-driven resistance to immune and targeted therapies in acral melanoma.
Rebecca Jane Lee, Garima Khandelwal, +14 authors, Richard Marais.
ESMO Open, 2020 Aug 21; 5(4). PMID: 32817058    Free PMC article.
The CCL5/CCR5 Axis in Cancer Progression.
Donatella Aldinucci, Cinzia Borghese, Naike Casagrande.
Cancers (Basel), 2020 Jul 08; 12(7). PMID: 32630699    Free PMC article.
Review.
A prognostic gene model of immune cell infiltration in diffuse large B-cell lymphoma.
Hao Zhou, Chang Zheng, De-Sheng Huang.
PeerJ, 2020 Aug 28; 8. PMID: 32844062    Free PMC article.
The Proteomic Effects of Pulsed Focused Ultrasound on Tumor Microenvironments of Murine Melanoma and Breast Cancer Models.
Omer Aydin, Parwathy Chandran, +3 authors, Joseph A Frank.
Ultrasound Med Biol, 2019 Sep 19; 45(12). PMID: 31530419    Free PMC article.
Selective inhibition of mTORC1 in tumor vessels increases antitumor immunity.
Shan Wang, Ariel Raybuck, +12 authors, Jin Chen.
JCI Insight, 2020 Aug 08; 5(15). PMID: 32759497    Free PMC article.
Role of Chemokines in the Biology of Cholangiocarcinoma.
Alessandra Caligiuri, Mirella Pastore, +4 authors, Alessandra Gentilini.
Cancers (Basel), 2020 Aug 14; 12(8). PMID: 32784743    Free PMC article.
Review.
Necroptosis in Immuno-Oncology and Cancer Immunotherapy.
Jenny Sprooten, Pieter De Wijngaert, +8 authors, Abhishek D Garg.
Cells, 2020 Aug 06; 9(8). PMID: 32752206    Free PMC article.
Review.
Understanding the Role of Innate Immune Cells and Identifying Genes in Breast Cancer Microenvironment.
Israa Shihab, Bariaa A Khalil, +4 authors, Azzam A Maghazachi.
Cancers (Basel), 2020 Aug 14; 12(8). PMID: 32784928    Free PMC article.
Review.
Environmental Carcinogenesis at the Single-Cell Level.
Gregory Chang, Kohei Saeki, Hitomi Mori, Shiuan Chen.
Cancer Epidemiol Biomarkers Prev, 2020 Mar 07; 29(10). PMID: 32132147    Free PMC article.
A Genetic Screen to Identify Gain- and Loss-of-Function Modifications that Enhance T-cell Infiltration into Tumors.
Laura M Rogers, Zhaoming Wang, +2 authors, George J Weiner.
Cancer Immunol Res, 2020 Jul 03; 8(9). PMID: 32611665    Free PMC article.
Cancer-Testis Gene Expression in Hepatocellular Carcinoma: Identification of Prognostic Markers and Potential Targets for Immunotherapy.
Yan-Peng Zhang, Zhi-Wei Bao, +6 authors, Shu-Sen Zheng.
Technol Cancer Res Treat, 2020 Jul 28; 19. PMID: 32715976    Free PMC article.
Exosomes: A Potential Therapeutic Tool Targeting Communications between Tumor Cells and Macrophages.
Weihua Guo, Yashan Li, Wei Pang, Hong Shen.
Mol Ther, 2020 Jun 22; 28(9). PMID: 32563274    Free PMC article.
Review.
β-Catenin inhibition shapes tumor immunity and synergizes with immunotherapy in colorectal cancer.
Caihong Wang, Jingjing Yan, +4 authors, Wei-Qiang Gao.
Oncoimmunology, 2020 Sep 18; 9(1). PMID: 32939327    Free PMC article.
Study on metastasis inhibition of Kejinyan decoction on lung cancer by affecting tumor microenvironment.
Meijuan Chen, Cheng Hu, +8 authors, Xu Zhang.
Cancer Cell Int, 2020 Sep 19; 20. PMID: 32943999    Free PMC article.
The modulation relationship of genomic pattern of intratumor heterogeneity and immunity microenvironment heterogeneity in hepatocellular carcinoma.
Liu-Bo Li, Lu Yang, +5 authors, Xiao-Dong Guo.
Oncol Lett, 2020 Sep 25; 20(5). PMID: 32968455    Free PMC article.
Unique Photochemo-Immuno-Nanoplatform against Orthotopic Xenograft Oral Cancer and Metastatic Syngeneic Breast Cancer.
Lu Zhang, Di Jing, +6 authors, Kit S Lam.
Nano Lett, 2018 Oct 20; 18(11). PMID: 30339018    Free PMC article.
Function and therapeutic advances of chemokine and its receptor in nonalcoholic fatty liver disease.
Wei Chen, Jing Zhang, Hui-Ning Fan, Jin-Shui Zhu.
Therap Adv Gastroenterol, 2018 Dec 24; 11. PMID: 30574191    Free PMC article.
Review.
Recent updates on cancer immunotherapy.
Ming Liu, Fukun Guo.
Precis Clin Med, 2019 Jan 29; 1(2). PMID: 30687562    Free PMC article.
Review.
CXCL13/CXCR5 Axis Predicts Poor Prognosis and Promotes Progression Through PI3K/AKT/mTOR Pathway in Clear Cell Renal Cell Carcinoma.
Zaosong Zheng, Yuhong Cai, +4 authors, Wenlian Xie.
Front Oncol, 2019 Feb 07; 8. PMID: 30723697    Free PMC article.
Computational Modeling of the Crosstalk Between Macrophage Polarization and Tumor Cell Plasticity in the Tumor Microenvironment.
Xuefei Li, Mohit Kumar Jolly, +2 authors, Herbert Levine.
Front Oncol, 2019 Feb 08; 9. PMID: 30729096    Free PMC article.
Targeting the Post-Irradiation Tumor Microenvironment in Glioblastoma via Inhibition of CXCL12.
Frank A Giordano, Barbara Link, +5 authors, Carsten Herskind.
Cancers (Basel), 2019 Mar 01; 11(3). PMID: 30813533    Free PMC article.
Review.
Macrophage Origin, Metabolic Reprogramming and IL-1 Signaling: Promises and Pitfalls in Lung Cancer.
Emma Guilbaud, Emmanuel L Gautier, Laurent Yvan-Charvet.
Cancers (Basel), 2019 Mar 06; 11(3). PMID: 30832375    Free PMC article.
Review.
Recent Advances in Cancer Stem Cell-Targeted Immunotherapy.
Narayanasamy Badrinath, So Young Yoo.
Cancers (Basel), 2019 Mar 08; 11(3). PMID: 30841635    Free PMC article.
Review.
The roles of homologous recombination and the immune system in the genomic evolution of cancer.
B Nandi, S Talluri, +5 authors, M A Shammas.
J Transl Sci, 2019 Mar 16; 5(2). PMID: 30873294    Free PMC article.
Emerging Nano-/Microapproaches for Cancer Immunotherapy.
Yu Mi, C Tilden Hagan, Benjamin G Vincent, Andrew Z Wang.
Adv Sci (Weinh), 2019 Apr 03; 6(6). PMID: 30937265    Free PMC article.
Review.
CCL2/CCR2 Axis Promotes the Progression of Salivary Adenoid Cystic Carcinoma via Recruiting and Reprogramming the Tumor-Associated Macrophages.
Zihui Yang, Huan Li, +7 authors, Xinjie Yang.
Front Oncol, 2019 Apr 27; 9. PMID: 31024838    Free PMC article.
Inhibition of PI3K pathway increases immune infiltrate in muscle-invasive bladder cancer.
Edith Borcoman, Philippe De La Rochere, +13 authors, Eliane Piaggio.
Oncoimmunology, 2019 May 10; 8(5). PMID: 31069145    Free PMC article.
Advances in Tumor-Stroma Interactions: Emerging Role of Cytokine Network in Colorectal and Pancreatic Cancer.
Chiara Bazzichetto, Fabiana Conciatori, +3 authors, Ludovica Ciuffreda.
J Oncol, 2019 Jun 14; 2019. PMID: 31191652    Free PMC article.
Review.
IL-4/IL-13 Stimulated Macrophages Enhance Breast Cancer Invasion Via Rho-GTPase Regulation of Synergistic VEGF/CCL-18 Signaling.
Andrew C Little, Pragathi Pathanjeli, +6 authors, Sofia D Merajver.
Front Oncol, 2019 Jun 20; 9. PMID: 31214501    Free PMC article.
Identifying Cancer Driver lncRNAs Bridged by Functional Effectors through Integrating Multi-omics Data in Human Cancers.
Yong Zhang, Gaoming Liao, +9 authors, Xia Li.
Mol Ther Nucleic Acids, 2019 Jul 16; 17. PMID: 31302496    Free PMC article.
RIG-I Promotes Cell Death in Hepatocellular Carcinoma by Inducing M1 Polarization of Perineal Macrophages Through the RIG-I/MAVS/NF-κB Pathway.
Bei Zhou, Cuiping Li, Yun Yang, Zhuo Wang.
Onco Targets Ther, 2020 Sep 29; 13. PMID: 32982277    Free PMC article.
Anti-angiogenic Agents in Combination With Immune Checkpoint Inhibitors: A Promising Strategy for Cancer Treatment.
Yuxiao Song, Yang Fu, +3 authors, Bicheng Zhang.
Front Immunol, 2020 Sep 29; 11. PMID: 32983126    Free PMC article.
Review.
EGFR/Ras-induced CCL20 production modulates the tumour microenvironment.
Andreas Hippe, Stephan Alexander Braun, +26 authors, Bernhard Homey.
Br J Cancer, 2020 Jul 01; 123(6). PMID: 32601464    Free PMC article.
CXCL5 expression in tumor tissues is associated with poor prognosis in patients with pancreatic cancer.
Bin Wu, Jing Wang, +4 authors, Zhengxiang Zhong.
Oncol Lett, 2020 Oct 01; 20(5). PMID: 32994820    Free PMC article.
Charge and Size Dual Switchable Nanocage for Novel Triple-Interlocked Combination Therapy Pattern.
Rui Yang, Zipeng Zhang, +8 authors, Na Zhang.
Adv Sci (Weinh), 2020 Oct 02; 7(18). PMID: 32999836    Free PMC article.
Externally-Controlled Systems for Immunotherapy: From Bench to Bedside.
María Tristán-Manzano, Pedro Justicia-Lirio, +3 authors, Francisco Martin.
Front Immunol, 2020 Oct 06; 11. PMID: 33013864    Free PMC article.
Review.
Impact of inflammation and immunotherapy in renal cell carcinoma.
Jian Shi, Keshan Wang, +10 authors, Xiaoping Zhang.
Oncol Lett, 2020 Oct 06; 20(5). PMID: 33014151    Free PMC article.
Review.
Black phosphorus-based photothermal therapy with aCD47-mediated immune checkpoint blockade for enhanced cancer immunotherapy.
Zhongjian Xie, Minhua Peng, +9 authors, Paras N Prasad.
Light Sci Appl, 2020 Oct 06; 9. PMID: 33014356    Free PMC article.
Omental macrophages secrete chemokine ligands that promote ovarian cancer colonization of the omentum via CCR1.
Venkatesh Krishnan, Supreeti Tallapragada, +9 authors, Oliver Dorigo.
Commun Biol, 2020 Sep 24; 3(1). PMID: 32963283    Free PMC article.
Regulation of tumor growth by leukocyte-specific protein 1 in T cells.
Riri Kwon, Bong-Ki Hong, +5 authors, Wan-Uk Kim.
J Immunother Cancer, 2020 Oct 07; 8(2). PMID: 33020243    Free PMC article.
Identification of small molecule drugs and development of a novel autophagy-related prognostic signature for kidney renal clear cell carcinoma.
Qianwei Xing, Chengjian Ji, +2 authors, Yi Wang.
Cancer Med, 2020 Aug 12; 9(19). PMID: 32780567    Free PMC article.
A Translational Study of a Silicon Phthalocyanine Substituted with a Histone Deacetylase Inhibitor for Photodynamic Therapy.
Başak Aru, Aysel Günay, +3 authors, Devrim Atilla.
ACS Omega, 2020 Oct 20; 5(40). PMID: 33073111    Free PMC article.
Toll-Like Receptor 3 as a Recurrence Risk Factor and a Potential Molecular Therapeutic Target in Colorectal Cancer.
Tatsuya Yoshida, Takuya Miura, +6 authors, Kenichi Hakamada.
Clin Exp Gastroenterol, 2020 Oct 17; 13. PMID: 33061521    Free PMC article.
Chemokine-like factor 1: A promising therapeutic target in human diseases.
Xiaopeng Cai, Jingwen Deng, +2 authors, Zhi Chen.
Exp Biol Med (Maywood), 2020 Jul 28; 245(16). PMID: 32715782    Free PMC article.
Review.
Immunomodulatory activity of IR700-labelled affibody targeting HER2.
Justyna Mączyńska, Chiara Da Pieve, +5 authors, Gabriela Kramer-Marek.
Cell Death Dis, 2020 Oct 22; 11(10). PMID: 33082328    Free PMC article.
Control of Cytoskeletal Dynamics by β-Arrestin1/Myosin Vb Signaling Regulates Endosomal Sorting and Scavenging Activity of the Atypical Chemokine Receptor ACKR2.
Alessandro Vacchini, Cinzia Cancellieri, +6 authors, Elena Monica Borroni.
Vaccines (Basel), 2020 Sep 23; 8(3). PMID: 32957704    Free PMC article.
Conjunctival Melanoma: Update on Genetics, Epigenetics and Targeted Molecular and Immune-Based Therapies.
Anastasia Gkiala, Sotiria Palioura.
Clin Ophthalmol, 2020 Oct 30; 14. PMID: 33116365    Free PMC article.
Review.
SHP2 inhibition diminishes KRASG12C cycling and promotes tumor microenvironment remodeling.
Carmine Fedele, Shuai Li, +20 authors, Benjamin G Neel.
J Exp Med, 2020 Oct 13; 218(1). PMID: 33045063    Free PMC article.
ATOH8 overexpression inhibits the tumor progression and monocyte chemotaxis in hepatocellular carcinoma.
Liping Chen, Jingmao Yang, +5 authors, Jilin Cheng.
Int J Clin Exp Pathol, 2020 Nov 10; 13(10). PMID: 33165366    Free PMC article.
Significance of the IL-8 pathway for immunotherapy.
Manuela Gonzalez-Aparicio, Carlos Alfaro.
Hum Vaccin Immunother, 2019 Dec 21; 16(10). PMID: 31860375    Free PMC article.
Stemness Related Genes Revealed by Network Analysis Associated With Tumor Immune Microenvironment and the Clinical Outcome in Lung Adenocarcinoma.
Hao Zeng, Jianrui Ji, +4 authors, Xuelei Ma.
Front Genet, 2020 Nov 17; 11. PMID: 33193623    Free PMC article.
A versatile system to record cell-cell interactions.
Rui Tang, Christopher W Murray, +9 authors, Monte M Winslow.
Elife, 2020 Oct 08; 9. PMID: 33025906    Free PMC article.
Modulation of the tumor microenvironment by natural agents: implications for cancer prevention and therapy.
Haseeb Zubair, Mohammad Aslam Khan, +3 authors, Ajay Pratap Singh.
Semin Cancer Biol, 2020 May 30;. PMID: 32470379    Free PMC article.
Review.
Intratumoral and peritumoral radiomics analysis for preoperative Lauren classification in gastric cancer.
Xiao-Xiao Wang, Yi Ding, +7 authors, Xiu-Hong Shan.
Cancer Imaging, 2020 Nov 25; 20(1). PMID: 33228815    Free PMC article.
The hallmarks of ovarian cancer: Focus on angiogenesis and micro-environment and new models for their characterisation.
V Heredia-Soto, J A López-Guerrero, A Redondo, M Mendiola.
EJC Suppl, 2020 Nov 27; 15. PMID: 33240442    Free PMC article.
B Cells versus T Cells in the Tumor Microenvironment of Malignant Lymphomas. Are the Lymphocytes Playing the Roles of Muhammad Ali versus George Foreman in Zaire 1974?
Minodora Desmirean, Sebastian Rauch, +16 authors, Ciprian Tomuleasa.
J Clin Med, 2020 Oct 30; 9(11). PMID: 33114418    Free PMC article.
Review.
Cancer/testis Antigen MAGEA3 Interacts with STAT1 and Remodels the Tumor Microenvironment.
Ying Wang, Xiao Song, +6 authors, Yanhui Yin.
Int J Med Sci, 2018 Dec 28; 15(14). PMID: 30588194    Free PMC article.
Chemokines and Chemokine Receptors: Orchestrating Tumor Metastasization.
Elisabetta Marcuzzi, Roberta Angioni, Barbara Molon, Bianca Calì.
Int J Mol Sci, 2018 Dec 29; 20(1). PMID: 30591657    Free PMC article.
Review.
Development and validation of an immune gene-set based Prognostic signature in ovarian cancer.
Sipeng Shen, Guanrong Wang, +4 authors, Feng Chen.
EBioMedicine, 2018 Dec 31; 40. PMID: 30594555    Free PMC article.
Chemoresistance: Intricate Interplay Between Breast Tumor Cells and Adipocytes in the Tumor Microenvironment.
Ilze Mentoor, Anna-Mart Engelbrecht, Paul J van Jaarsveld, Theo Nell.
Front Endocrinol (Lausanne), 2019 Jan 09; 9. PMID: 30619088    Free PMC article.
Review.
[Recent developments in head and neck immunology : A basis for novel therapeutic strategies?]
C A Reichel.
HNO, 2019 Mar 16; 67(4). PMID: 30874856
Review.
Microvesicles and chemokines in tumor microenvironment: mediators of intercellular communications in tumor progression.
Xiaojie Bian, Yu-Tian Xiao, +4 authors, Jianhua Wang.
Mol Cancer, 2019 Mar 31; 18(1). PMID: 30925930    Free PMC article.
Review.
PIM1 is responsible for IL-6-induced breast cancer cell EMT and stemness via c-myc activation.
Xueqiang Gao, Xiangping Liu, +5 authors, Haibo Wang.
Breast Cancer, 2019 Apr 17; 26(5). PMID: 30989585    Free PMC article.
The Expression of the Chemokine CXCL14 Correlates with Several Aggressive Aspects of Glioblastoma and Promotes Key Properties of Glioblastoma Cells.
Barbara Fazi, Carla Proserpio, +5 authors, Silvia Anna Ciafrè.
Int J Mol Sci, 2019 May 24; 20(10). PMID: 31117166    Free PMC article.
Resolution of Gastric Cancer-Promoting Inflammation: A Novel Strategy for Anti-cancer Therapy.
M Blanca Piazuelo, Rachel P Riechelmann, Keith T Wilson, Holly M Scott Algood.
Curr Top Microbiol Immunol, 2019 May 28; 421. PMID: 31123895    Free PMC article.
Review.
Synthesized natural peptides from amphibian skin secretions increase the efficacy of a therapeutic vaccine by recruiting more T cells to the tumour site.
Xuan Pan, Bowei Ma, +10 authors, Xiaosong Liu.
BMC Complement Altern Med, 2019 Jul 07; 19(1). PMID: 31277636    Free PMC article.
Functional and mechanistic studies reveal MAGEA3 as a pro-survival factor in pancreatic cancer cells.
Biswajit Das, Shantibhusan Senapati.
J Exp Clin Cancer Res, 2019 Jul 10; 38(1). PMID: 31287009    Free PMC article.
IFI30 expression is an independent unfavourable prognostic factor in glioma.
Xiu Liu, Chunyan Song, +3 authors, Wenbin Li.
J Cell Mol Med, 2020 Sep 25; 24(21). PMID: 32969157    Free PMC article.
Cellular and gene signatures of tumor-infiltrating dendritic cells and natural-killer cells predict prognosis of neuroblastoma.
Ombretta Melaiu, Marco Chierici, +10 authors, Doriana Fruci.
Nat Commun, 2020 Nov 27; 11(1). PMID: 33239635    Free PMC article.
Impact of the Chemokine Receptors CXCR4 and CXCR7 on Clinical Outcome in Adrenocortical Carcinoma.
Irina Chifu, Britta Heinze, +8 authors, Stefanie Hahner.
Front Endocrinol (Lausanne), 2020 Dec 08; 11. PMID: 33281749    Free PMC article.
Comprehensive analysis of prognostic gene signatures based on immune infiltration of ovarian cancer.
Shibai Yan, Juntao Fang, +4 authors, Feng Fang.
BMC Cancer, 2020 Dec 09; 20(1). PMID: 33287740    Free PMC article.
Follistatin-like 1 (FSTL1) is a prognostic biomarker and correlated with immune cell infiltration in gastric cancer.
Li Li, Shanshan Huang, +5 authors, Jianping Xiong.
World J Surg Oncol, 2020 Dec 10; 18(1). PMID: 33292276    Free PMC article.
CXCR7: a β-arrestin-biased receptor that potentiates cell migration and recruits β-arrestin2 exclusively through Gβγ subunits and GRK2.
Huong Thi Nguyen, Arfaxad Reyes-Alcaraz, +6 authors, Jong-Ik Hwang.
Cell Biosci, 2020 Dec 10; 10(1). PMID: 33292475    Free PMC article.
Genomic investigation of co-targeting tumor immune microenvironment and immune checkpoints in pan-cancer immunotherapy.
Xing Huang, Tianyu Tang, +5 authors, Tingbo Liang.
NPJ Precis Oncol, 2020 Dec 11; 4(1). PMID: 33299118    Free PMC article.
Targeting tumor microenvironment as a treatment strategy for hepatocellular carcinoma.
Zuyuan Lin, Xiaonan Xiang, Di Lu, Xiao Xu.
Hepatobiliary Surg Nutr, 2020 Dec 11; 9(6). PMID: 33299838    Free PMC article.
Merkel cell carcinoma-derived exosome-shuttle miR-375 induces fibroblast polarization by inhibition of RBPJ and p53.
Kaiji Fan, Ivelina Spassova, +9 authors, Jürgen C Becker.
Oncogene, 2020 Dec 15; 40(5). PMID: 33311552    Free PMC article.
The Role of CCL20-CCR6 Axis in Ovarian Cancer Metastasis.
Wan Liu, Wenjing Wang, Ning Zhang, Wen Di.
Onco Targets Ther, 2020 Dec 19; 13. PMID: 33335408    Free PMC article.
An immune-relevant signature of nine genes as a prognostic biomarker in patients with gastric carcinoma.
Bing Wang, Yang Zhang.
Open Med (Wars), 2020 Dec 19; 15(1). PMID: 33336043    Free PMC article.
Long-Range Coupled Motions Underlie Ligand Recognition by a Chemokine Receptor.
Krishna Mohan Sepuru, Vinay Nair, +2 authors, Krishna Rajarathnam.
iScience, 2020 Dec 22; 23(12). PMID: 33344917    Free PMC article.
T Cell Dysfunction in Cancer.
Daniela S Thommen, Ton N Schumacher.
Cancer Cell, 2018 Apr 11; 33(4). PMID: 29634943    Free PMC article.
Highly Cited. Review.
Gene Augmentation and Editing to Improve TCR Engineered T Cell Therapy against Solid Tumors.
Vania Lo Presti, Frank Buitenwerf, Niek P van Til, Stefan Nierkens.
Vaccines (Basel), 2020 Dec 09; 8(4). PMID: 33287413    Free PMC article.
Review.
Strategies to Improve Chimeric Antigen Receptor Therapies for Neuroblastoma.
Piamsiri Sawaisorn, Korakot Atjanasuppat, +2 authors, Suradej Hongeng.
Vaccines (Basel), 2020 Dec 17; 8(4). PMID: 33322408    Free PMC article.
Review.
Intrahepatic cholangiocarcinoma induced M2-polarized tumor-associated macrophages facilitate tumor growth and invasiveness.
Hui Yuan, Zelong Lin, +6 authors, Jian Hong.
Cancer Cell Int, 2020 Dec 30; 20(1). PMID: 33372604    Free PMC article.
Role of inflammatory microenvironment: potential implications for improved breast cancer nano-targeted therapy.
Meng Lan, Wenping Lu, +4 authors, Yu Cai.
Cell Mol Life Sci, 2021 Jan 03; 78(5). PMID: 33386887
Review.
ER stress-induced mediator C/EBP homologous protein thwarts effector T cell activity in tumors through T-bet repression.
Yu Cao, Jimena Trillo-Tinoco, +16 authors, Paulo C Rodriguez.
Nat Commun, 2019 Mar 22; 10(1). PMID: 30894532    Free PMC article.
A toll-like receptor agonist mimicking microbial signal to generate tumor-suppressive macrophages.
Yanxian Feng, Ruoyu Mu, +4 authors, Chunming Wang.
Nat Commun, 2019 May 24; 10(1). PMID: 31118418    Free PMC article.
Eomes promotes esophageal carcinoma progression by recruiting Treg cells through the CCL20-CCR6 pathway.
Jingyao Lian, Saisai Liu, +4 authors, Yi Zhang.
Cancer Sci, 2020 Oct 29; 112(1). PMID: 33113266    Free PMC article.
Genetic Variants in Immune Related Genes as Predictors of Responsiveness to BCG Immunotherapy in Metastatic Melanoma Patients.
Romela Irene Ramos, Misa A Shaw, +4 authors, Dave S B Hoon.
Cancers (Basel), 2021 Jan 06; 13(1). PMID: 33396862    Free PMC article.
Immune Characterization of Ovarian Cancer Reveals New Cell Subtypes With Different Prognoses, Immune Risks, and Molecular Mechanisms.
Shanshan Cong, Qiuyan Guo, +5 authors, Guangmei Zhang.
Front Cell Dev Biol, 2021 Jan 08; 8. PMID: 33409283    Free PMC article.
Fueling chimeric antigen receptor T cells with cytokines.
Jin Jin, Jiali Cheng, +2 authors, Jianfeng Zhou.
Am J Cancer Res, 2021 Jan 09; 10(12). PMID: 33414984    Free PMC article.
Review.
Infiltration of Immunoinflammatory Cells and Related Chemokine/Interleukin Expression in Different Gastric Immune Microenvironments.
Ang Wang, Siru Nie, +2 authors, Yuan Yuan.
J Immunol Res, 2021 Jan 12; 2020. PMID: 33426088    Free PMC article.
Exploration of the relationship between tumor mutation burden and immune infiltrates in colon adenocarcinoma.
Rong Ouyang, Zhongzhuan Li, +4 authors, Jiean Huang.
Int J Med Sci, 2021 Jan 14; 18(3). PMID: 33437203    Free PMC article.
Single-cell transcriptomics reveals regulators underlying immune cell diversity and immune subtypes associated with prognosis in nasopharyngeal carcinoma.
Yu-Pei Chen, Jian-Hua Yin, +28 authors, Jun Ma.
Cell Res, 2020 Jul 21; 30(11). PMID: 32686767    Free PMC article.
Cross-linking of T cell to B cell lymphoma by the T cell bispecific antibody CD20-TCB induces IFNγ/CXCL10-dependent peripheral T cell recruitment in humanized murine model.
Floriana Cremasco, Elena Menietti, +9 authors, Mario Perro.
PLoS One, 2021 Jan 07; 16(1). PMID: 33406104    Free PMC article.
Skin dendritic cells in melanoma are key for successful checkpoint blockade therapy.
Anastasia Prokopi, Christoph H Tripp, +18 authors, Patrizia Stoitzner.
J Immunother Cancer, 2021 Jan 08; 9(1). PMID: 33408092    Free PMC article.
CXCL12-mediated HOXB5 overexpression facilitates Colorectal Cancer metastasis through transactivating CXCR4 and ITGB3.
Weibo Feng, Wenjie Huang, +12 authors, Limin Xia.
Theranostics, 2021 Jan 19; 11(6). PMID: 33456563    Free PMC article.
Pirfenidone facilitates immune infiltration and enhances the antitumor efficacy of PD-L1 blockade in mice.
Wan Qin, Jun Zou, +8 authors, Xianglin Yuan.
Oncoimmunology, 2021 Jan 19; 9(1). PMID: 33457101    Free PMC article.
Antitumour immunity regulated by aberrant ERBB family signalling.
Shogo Kumagai, Shohei Koyama, Hiroyoshi Nishikawa.
Nat Rev Cancer, 2021 Jan 20; 21(3). PMID: 33462501
Review.
Insight into next-generation CAR therapeutics: designing CAR T cells to improve clinical outcomes.
Emiliano Roselli, Rawan Faramand, Marco L Davila.
J Clin Invest, 2021 Jan 20; 131(2). PMID: 33463538    Free PMC article.
Review.
CX3 CL1 promotes tumour cell by inducing tyrosine phosphorylation of cortactin in lung cancer.
Mengtian Fan, Jinghong Wu, +11 authors, Qiong Shi.
J Cell Mol Med, 2020 Nov 17; 25(1). PMID: 33191645    Free PMC article.
The Network of Cytokines in Brain Metastases.
Jawad Fares, Alex Cordero, Deepak Kanojia, Maciej S Lesniak.
Cancers (Basel), 2021 Jan 21; 13(1). PMID: 33466236    Free PMC article.
Review.
Recent Discoveries of Macromolecule- and Cell-Based Biomarkers and Therapeutic Implications in Breast Cancer.
Hsing-Ju Wu, Pei-Yi Chu.
Int J Mol Sci, 2021 Jan 14; 22(2). PMID: 33435254    Free PMC article.
Review.
Role of epidermal growth factor receptor inhibitor-induced interferon pathway signaling in the head and neck squamous cell carcinoma therapeutic response.
Sean P Korpela, Trista K Hinz, +7 authors, Lynn E Heasley.
J Transl Med, 2021 Jan 25; 19(1). PMID: 33485341    Free PMC article.
Recent updates on chimeric antigen receptor T cell therapy for hepatocellular carcinoma.
Jiaojiao Guo, Qi Tang.
Cancer Gene Ther, 2021 Jan 28;. PMID: 33500535
Review.
CCL16 maintains stem cell-like properties in breast cancer by activating CCR2/GSK3β/β-catenin/OCT4 axis.
Wenzhi Shen, Xiaoyuan Zhang, +13 authors, Jianjun Li.
Theranostics, 2021 Jan 28; 11(5). PMID: 33500726    Free PMC article.
Brain tumors: Cancer stem-like cells interact with tumor microenvironment.
Hai-Long Liu, Ya-Nan Wang, Shi-Yu Feng.
World J Stem Cells, 2021 Jan 29; 12(12). PMID: 33505594    Free PMC article.
Review.
Advanced lung cancer inflammation index and its prognostic value in HPV-negative head and neck squamous cell carcinoma: a multicentre study.
Piergiorgio Gaudioso, Daniele Borsetto, +19 authors, Paolo Boscolo-Rizzo.
Support Care Cancer, 2021 Jan 31;. PMID: 33515105
IL-36γ-armed oncolytic virus exerts superior efficacy through induction of potent adaptive antitumor immunity.
Min Yang, Esther Giehl, +9 authors, Zong Sheng Guo.
Cancer Immunol Immunother, 2021 Feb 05;. PMID: 33538860
A programmable polymer library that enables the construction of stimuli-responsive nanocarriers containing logic gates.
Penghui Zhang, Di Gao, +15 authors, Weihong Tan.
Nat Chem, 2020 Mar 11; 12(4). PMID: 32152477
Cancer stem cells: Regulation programs, immunological properties and immunotherapy.
Dingxiao Zhang, Dean G Tang, Kiera Rycaj.
Semin Cancer Biol, 2018 May 13; 52(Pt 2). PMID: 29752993    Free PMC article.
Review.
Therapy-Induced Evolution of Human Lung Cancer Revealed by Single-Cell RNA Sequencing.
Ashley Maynard, Caroline E McCoach, +40 authors, Trever G Bivona.
Cell, 2020 Aug 22; 182(5). PMID: 32822576    Free PMC article.
Genetically Defined, Syngeneic Organoid Platform for Developing Combination Therapies for Ovarian Cancer.
Shuang Zhang, Sonia Iyer, +10 authors, Benjamin G Neel.
Cancer Discov, 2020 Nov 08; 11(2). PMID: 33158842    Free PMC article.
Radiation-induced eosinophils improve cytotoxic T lymphocyte recruitment and response to immunotherapy.
Jia-Nan Cheng, Wen Luo, +12 authors, Bo Zhu.
Sci Adv, 2021 Jan 31; 7(5). PMID: 33514544    Free PMC article.
Siglec15 shapes a non-inflamed tumor microenvironment and predicts the molecular subtype in bladder cancer.
Jiao Hu, Anze Yu, +11 authors, Xiongbing Zu.
Theranostics, 2021 Feb 05; 11(7). PMID: 33537076    Free PMC article.
SGK1 in Human Cancer: Emerging Roles and Mechanisms.
Yiwen Sang, Piaoping Kong, +6 authors, Weiwei Liu.
Front Oncol, 2021 Feb 06; 10. PMID: 33542904    Free PMC article.
Review.
TGF-β in Cancer: Metabolic Driver of the Tolerogenic Crosstalk in the Tumor Microenvironment.
Roberta Angioni, Ricardo Sánchez-Rodríguez, Antonella Viola, Barbara Molon.
Cancers (Basel), 2021 Jan 28; 13(3). PMID: 33499083    Free PMC article.
Review.
SOX18 promotes gastric cancer metastasis through transactivating MCAM and CCL7.
Jie Chen, Yunzhi Dang, +9 authors, Limin Xia.
Oncogene, 2020 Jul 04; 39(33). PMID: 32616889
First-in-Human Phase I Clinical Trial of an SFV-Based RNA Replicon Cancer Vaccine against HPV-Induced Cancers.
Fenne L Komdeur, Amrita Singh, +20 authors, Toos Daemen.
Mol Ther, 2020 Nov 08; 29(2). PMID: 33160073    Free PMC article.
Modeling the tumor immune microenvironment for drug discovery using 3D culture.
Joanna Y Lee, Ovijit Chaudhuri.
APL Bioeng, 2021 Feb 11; 5(1). PMID: 33564739    Free PMC article.
PLAU directs conversion of fibroblasts to inflammatory cancer-associated fibroblasts, promoting esophageal squamous cell carcinoma progression via uPAR/Akt/NF-κB/IL8 pathway.
Lingling Fang, Yun Che, +5 authors, Jie He.
Cell Death Discov, 2021 Feb 13; 7(1). PMID: 33574243    Free PMC article.
Bioinformatics and immunohistochemistry analyses of expression levels and clinical significance of CXCL2 and TANs in an oral squamous cell carcinoma tumor microenvironment of Prophyromonas gingivalis infection.
Zhi-Chen Guo, Sakendeke Jumatai, +3 authors, Zhong-Cheng Gong.
Oncol Lett, 2021 Feb 13; 21(3). PMID: 33574928    Free PMC article.
Immunotherapy efficacy on mismatch repair-deficient colorectal cancer: From bench to bedside.
Darleny Y Lizardo, Chaoyuan Kuang, +3 authors, Lin Zhang.
Biochim Biophys Acta Rev Cancer, 2020 Oct 10; 1874(2). PMID: 33035640    Free PMC article.
Review.
Advantages of targeting the tumor immune microenvironment over blocking immune checkpoint in cancer immunotherapy.
Tianyu Tang, Xing Huang, +3 authors, Tingbo Liang.
Signal Transduct Target Ther, 2021 Feb 21; 6(1). PMID: 33608497    Free PMC article.
Review.
Overcoming biological barriers to improve solid tumor immunotherapy.
Anvay Ukidve, Katharina Cu, +2 authors, Samir Mitragotri.
Drug Deliv Transl Res, 2021 Feb 22;. PMID: 33611770
Targeting tumor-associated macrophages to synergize tumor immunotherapy.
Xiaonan Xiang, Jianguo Wang, Di Lu, Xiao Xu.
Signal Transduct Target Ther, 2021 Feb 24; 6(1). PMID: 33619259    Free PMC article.
Review.
Epigenetic regulation of miR-518a-5p-CCR6 feedback loop promotes both proliferation and invasion in diffuse large B cell lymphoma.
Qian Huang, Feng Zhang, Haiying Fu, Jianzhen Shen.
Epigenetics, 2020 Jul 01; 16(1). PMID: 32600091    Free PMC article.
Chimeric antigen receptor (CAR)-T-cell therapy in non-small-cell lung cancer (NSCLC): current status and future perspectives.
Jingjing Qu, Quanhui Mei, Lijun Chen, Jianying Zhou.
Cancer Immunol Immunother, 2020 Oct 08; 70(3). PMID: 33025047    Free PMC article.
Review.
Cancer Immunoprevention: Current Status and Future Directions.
Mahsa Keshavarz-Fathi, Nima Rezaei.
Arch Immunol Ther Exp (Warsz), 2021 Feb 28; 69(1). PMID: 33638703
Review.
Targeting and Reprograming Cancer-Associated Fibroblasts and the Tumor Microenvironment in Pancreatic Cancer.
Yoshiaki Sunami, Viktoria Böker, Jörg Kleeff.
Cancers (Basel), 2021 Feb 13; 13(4). PMID: 33572223    Free PMC article.
Review.
Blocking Migration of Polymorphonuclear Myeloid-Derived Suppressor Cells Inhibits Mouse Melanoma Progression.
Christopher Groth, Ludovica Arpinati, +12 authors, Viktor Umansky.
Cancers (Basel), 2021 Feb 14; 13(4). PMID: 33578808    Free PMC article.
Blinatumomab-induced T cell activation at single cell transcriptome resolution.
Yi Huo, Zhen Sheng, +6 authors, Ruibao Ren.
BMC Genomics, 2021 Mar 03; 22(1). PMID: 33648458    Free PMC article.
Re-Clustering and Profiling of Digestive System Tumors According to Microenvironment Components.
Yongwei Wang, Sen Guo, +3 authors, Yaxian Gao.
Front Oncol, 2021 Mar 02; 10. PMID: 33643909    Free PMC article.
Tumor Vasculatures: A New Target for Cancer Immunotherapy.
Zhigang Liu, Yifan Wang, +4 authors, Wen Jiang.
Trends Pharmacol Sci, 2019 Jul 25; 40(9). PMID: 31331639    Free PMC article.
Review.
Research Trends and Regulation of CCL5 in Prostate Cancer.
Renlun Huang, Lang Guo, +2 authors, Songtao Xiang.
Onco Targets Ther, 2021 Mar 06; 14. PMID: 33664576    Free PMC article.
Review.
Metabolic Factors Affecting Tumor Immunogenicity: What Is Happening at the Cellular Level?
Rola El Sayed, Yolla Haibe, +2 authors, Ali Shamseddine.
Int J Mol Sci, 2021 Mar 07; 22(4). PMID: 33670011    Free PMC article.
Review.
Role of chemokines in hepatocellular carcinoma (Review).
Dongdong Xue, Ya Zheng, +4 authors, Yanhui Peng.
Oncol Rep, 2021 Mar 03; 45(3). PMID: 33650640    Free PMC article.
Pentagalloyl glucose inhibits TNF-α-activated CXCL1/GRO-α expression and induces apoptosis-related genes in triple-negative breast cancer cells.
Patricia Mendonca, Sumaih Alghamdi, Samia Messeha, Karam F A Soliman.
Sci Rep, 2021 Mar 13; 11(1). PMID: 33707603    Free PMC article.
Enhancing delivery of small molecule and cell-based therapies for ovarian cancer using advanced delivery strategies.
Joanne O'Dwyer, Roisin E O'Cearbhaill, +4 authors, Eimear B Dolan.
Adv Ther (Weinh), 2021 Mar 13; 3(11). PMID: 33709016    Free PMC article.
Single-cell transcriptome analysis revealed the heterogeneity and microenvironment of gastrointestinal stromal tumors.
Xiaofan Mao, Xuezhu Yang, +7 authors, Wei Luo.
Cancer Sci, 2021 Jan 05; 112(3). PMID: 33393143    Free PMC article.
A Prognostic Signature Based on Immunogenomic Profiling Offers Guidance for Esophageal Squamous Cell Cancer Treatment.
Jianyao Gao, Ting Tang, Baohui Zhang, Guang Li.
Front Oncol, 2021 Mar 16; 11. PMID: 33718151    Free PMC article.
Underlying mechanisms and drug intervention strategies for the tumour microenvironment.
Haoze Li, Lihong Zhou, +2 authors, Qing Ji.
J Exp Clin Cancer Res, 2021 Mar 17; 40(1). PMID: 33722297    Free PMC article.
Review.
Comparative Proteome Identifies Complement Component 3-Mediated Immune Response as Key Difference of Colon Adenocarcinoma and Rectal Adenocarcinoma.
Jun-Ze Liang, Xiao-Ling Liang, +3 authors, Yang Wang.
Front Oncol, 2021 Mar 19; 10. PMID: 33732636    Free PMC article.
Targeting chemokines for acute lymphoblastic leukemia therapy.
Zixi Hong, Zimeng Wei, +6 authors, Liang Shao.
J Hematol Oncol, 2021 Mar 22; 14(1). PMID: 33743810    Free PMC article.
Review.
Circadian clock: a regulator of the immunity in cancer.
Zhen Zhang, Puhua Zeng, +3 authors, Xuefei Tian.
Cell Commun Signal, 2021 Mar 24; 19(1). PMID: 33752691    Free PMC article.
Review.
Topological Tumor Graphs: A Graph-Based Spatial Model to Infer Stromal Recruitment for Immunosuppression in Melanoma Histology.
Henrik Failmezger, Sathya Muralidhar, +3 authors, Yinyin Yuan.
Cancer Res, 2019 Dec 26; 80(5). PMID: 31874858    Free PMC article.
Autophagy in tumour immunity and therapy.
Houjun Xia, Douglas R Green, Weiping Zou.
Nat Rev Cancer, 2021 Mar 25; 21(5). PMID: 33758415    Free PMC article.
Review.
Perspective of mesenchymal transformation in glioblastoma.
Yona Kim, Frederick S Varn, +5 authors, Sun Ha Paek.
Acta Neuropathol Commun, 2021 Mar 26; 9(1). PMID: 33762019    Free PMC article.
Review.
Phenotypic characterization of auxotrophic mutant of nontyphoidal Salmonella and determination of its cytotoxicity, tumor inhibiting cytokine gene expression in cell line models.
Kadeeja Jazeela, Anirban Chakraborty, +5 authors, Vijaya Kumar Deekshit.
Arch Microbiol, 2021 Mar 27;. PMID: 33770232
Immune cell profiling of the cerebrospinal fluid enables the characterization of the brain metastasis microenvironment.
Carlota Rubio-Perez, Ester Planas-Rigol, +20 authors, Joan Seoane.
Nat Commun, 2021 Mar 10; 12(1). PMID: 33686071    Free PMC article.
Identification and development of an independent immune-related genes prognostic model for breast cancer.
Lin Chen, Yuxiang Dong, +7 authors, Rong Deng.
BMC Cancer, 2021 Apr 01; 21(1). PMID: 33785008    Free PMC article.
FGL2-wired macrophages secrete CXCL7 to regulate the stem-like functionality of glioma cells.
Jun Yan, Qingnan Zhao, +7 authors, Shulin Li.
Cancer Lett, 2021 Mar 08; 506. PMID: 33676940    Free PMC article.
Interferon regulatory factor 1(IRF-1) activates anti-tumor immunity via CXCL10/CXCR3 axis in hepatocellular carcinoma (HCC).
Yihe Yan, Leting Zheng, +4 authors, David A Geller.
Cancer Lett, 2021 Mar 11; 506. PMID: 33689775    Free PMC article.
A Critical Role of Peptidylprolyl Isomerase A Pseudogene 22/microRNA-197-3p/Peptidylprolyl Isomerase A Axis in Hepatocellular Carcinoma.
Yuwei Gu, Chao Wang, +7 authors, Mingquan Chen.
Front Genet, 2021 Apr 02; 12. PMID: 33790943    Free PMC article.
CXCL10 Is an Agonist of the CC Family Chemokine Scavenger Receptor ACKR2/D6.
Andy Chevigné, Bassam Janji, +9 authors, Martyna Szpakowska.
Cancers (Basel), 2021 Apr 04; 13(5). PMID: 33801414    Free PMC article.
Oncolytic Adenoviruses for Cancer Therapy.
Lorella Tripodi, Maria Vitale, Vincenzo Cerullo, Lucio Pastore.
Int J Mol Sci, 2021 Apr 04; 22(5). PMID: 33802281    Free PMC article.
Review.
Characteristics of B lymphocyte infiltration in HPV+ head and neck squamous cell carcinoma.
Siwei Zhang, Bozhi Wang, +7 authors, Lanlan Wei.
Cancer Sci, 2021 Feb 03; 112(4). PMID: 33529452    Free PMC article.
Pulsed-Focused Ultrasound Slows B16 Melanoma and 4T1 Breast Tumor Growth through Differential Tumor Microenvironmental Changes.
Gadi Cohen, Parwathy Chandran, +5 authors, Joseph A Frank.
Cancers (Basel), 2021 Apr 04; 13(7). PMID: 33801627    Free PMC article.
Effects of the Anti-Tumorigenic Agent AT101 on Human Glioblastoma Cells in the Microenvironmental Glioma Stem Cell Niche.
Deniz Caylioglu, Rieke Johanna Meyer, +3 authors, Janka Held-Feindt.
Int J Mol Sci, 2021 Apr 04; 22(7). PMID: 33808494    Free PMC article.
NLRP7 deubiquitination by USP10 promotes tumor progression and tumor-associated macrophage polarization in colorectal cancer.
Bing Li, Zhi-Peng Qi, +11 authors, Yun-Shi Zhong.
J Exp Clin Cancer Res, 2021 Apr 12; 40(1). PMID: 33838681    Free PMC article.
Stanniocalcin 1 is a phagocytosis checkpoint driving tumor immune resistance.
Heng Lin, Ilona Kryczek, +23 authors, Weiping Zou.
Cancer Cell, 2021 Jan 30; 39(4). PMID: 33513345    Free PMC article.
Increased tumor-infiltrating plasmacytoid dendritic cells promote cancer cell proliferation and invasion via TNF-α/NF-κB/CXCR-4 pathway in oral squamous cell carcinoma.
Nannan Han, Xing Li, +5 authors, Chenping Zhang.
J Cancer, 2021 Apr 16; 12(10). PMID: 33854604    Free PMC article.
Cancer immune control dynamics: a clinical data driven model of systemic immunity in patients with metastatic melanoma.
Harold P Frisch, Allan Sprau, +5 authors, Svetomir N Markovic.
BMC Bioinformatics, 2021 Apr 18; 22(1). PMID: 33863290    Free PMC article.
CCR7 Has Potential to Be a Prognosis Marker for Cervical Squamous Cell Carcinoma and an Index for Tumor Microenvironment Change.
Wei-Jie Tian, Peng-Hui Feng, +4 authors, Wen-Tong Liang.
Front Mol Biosci, 2021 Apr 20; 8. PMID: 33869272    Free PMC article.
Mining TCGA Data for Key Biomarkers Related to Immune Microenvironment in Endometrial cancer by Immune Score and Weighted Correlation Network Analysis.
Chengbin Guo, Yuqin Tang, Yongqiang Zhang, Gen Li.
Front Mol Biosci, 2021 Apr 20; 8. PMID: 33869285    Free PMC article.
Tumor-associated macrophages secret exosomal miR-155 and miR-196a-5p to promote metastasis of non-small-cell lung cancer.
Xiang Li, Zhipeng Chen, +5 authors, Jun Wang.
Transl Lung Cancer Res, 2021 Apr 24; 10(3). PMID: 33889514    Free PMC article.
The tumour immune microenvironment in oesophageal cancer.
Maria Davern, Noel E Donlon, +4 authors, John V Reynolds.
Br J Cancer, 2021 Apr 28;. PMID: 33903730
Review.
Genetic engineering cellular vesicles expressing CD64 as checkpoint antibody carrier for cancer immunotherapy.
Liyan Li, Qianwei Miao, +12 authors, Xudong Zhang.
Theranostics, 2021 Apr 27; 11(12). PMID: 33897897    Free PMC article.
Triple-Negative Breast Cancer Cells Recruit Neutrophils by Secreting TGF-β and CXCR2 Ligands.
Shuvasree SenGupta, Lauren E Hein, +7 authors, Carole A Parent.
Front Immunol, 2021 Apr 30; 12. PMID: 33912188    Free PMC article.
The Tumour Vasculature as a Target to Modulate Leucocyte Trafficking.
Yang Zhao, Ka Ka Ting, +4 authors, Jennifer Gamble.
Cancers (Basel), 2021 May 01; 13(7). PMID: 33917287    Free PMC article.
Review.
Tumor-Associated Macrophages-Implications for Molecular Oncology and Imaging.
Melanie A Kimm, Christopher Klenk, +5 authors, Moritz Wildgruber.
Biomedicines, 2021 May 01; 9(4). PMID: 33918295    Free PMC article.
Review.
Recruitment and Expansion of Tregs Cells in the Tumor Environment-How to Target Them?
Justine Cinier, Margaux Hubert, +5 authors, Christine Ménétrier-Caux.
Cancers (Basel), 2021 May 01; 13(8). PMID: 33924428    Free PMC article.
Review.
The Cancer Cell Dissemination Machinery as an Immunosuppressive Niche: A New Obstacle Towards the Era of Cancer Immunotherapy.
Saeed Asiry, Gina Kim, +5 authors, George S Karagiannis.
Front Immunol, 2021 May 01; 12. PMID: 33927723    Free PMC article.
Review.
SOX4 activates CXCL12 in hepatocellular carcinoma cells to modulate endothelial cell migration and angiogenesis in vivo.
Chi-Neu Tsai, Shu-Chuan Yu, +7 authors, Ming-Chin Yu.
Oncogene, 2020 May 15; 39(24). PMID: 32404985
Chemokines orchestrate tumor cells and the microenvironment to achieve metastatic heterogeneity.
Sugandha Saxena, Rakesh K Singh.
Cancer Metastasis Rev, 2021 May 08;. PMID: 33959849
Review.
Systemic tumour suppression via the preferential accumulation of erythrocyte-anchored chemokine-encapsulating nanoparticles in lung metastases.
Zongmin Zhao, Anvay Ukidve, +9 authors, Samir Mitragotri.
Nat Biomed Eng, 2020 Nov 18; 5(5). PMID: 33199847
Navigating CAR-T cells through the solid-tumour microenvironment.
Andrew J Hou, Laurence C Chen, Yvonne Y Chen.
Nat Rev Drug Discov, 2021 May 12;. PMID: 33972771
Review.
Exosomes derived from miR-1228 overexpressing bone marrow-mesenchymal stem cells promote growth of gastric cancer cells.
Lili Chang, He Gao, +4 authors, Huijun Yang.
Aging (Albany NY), 2021 Apr 23; 13(8). PMID: 33883305    Free PMC article.
Blood-brain barrier opening by intracarotid artery hyperosmolar mannitol induces sterile inflammatory and innate immune responses.
Scott R Burks, Cymon N Kersch, +5 authors, Joseph A Frank.
Proc Natl Acad Sci U S A, 2021 Apr 29; 118(18). PMID: 33906946    Free PMC article.
Relationship between Tertiary Lymphoid Structure and the Prognosis and Clinicopathologic Characteristics in Solid Tumors.
Zhan Zhao, Hui Ding, +7 authors, Yun-Long Pan.
Int J Med Sci, 2021 May 11; 18(11). PMID: 33967609    Free PMC article.
Identification of the dominant angiogenic CXCL class chemokines associated with non-small cell lung cancer via bioinformatics tools.
Nese Unver.
Med Oncol, 2021 May 14; 38(6). PMID: 33983509
Elevated RBP-Jκ and CXCL11 Expression in Colon Cancer is Associated with an Unfavorable Clinical Outcome.
Meng-Jie Liu, Hui Guo, +5 authors, Wen-Juan Wang.
Cancer Manag Res, 2021 May 14; 13. PMID: 33981164    Free PMC article.
Multi-omic profiling of lung and liver tumor microenvironments of metastatic pancreatic cancer reveals site-specific immune regulatory pathways.
Won Jin Ho, Rossin Erbe, +16 authors, Elana J Fertig.
Genome Biol, 2021 May 15; 22(1). PMID: 33985562    Free PMC article.
Modulation of the chemokine/chemokine receptor axis as a novel approach for glioma therapy.
Gregory P Takacs, Joseph A Flores-Toro, Jeffrey K Harrison.
Pharmacol Ther, 2020 Dec 15; 222. PMID: 33316289    Free PMC article.
Review.
Single-cell transcriptome profiling reveals vascular endothelial cell heterogeneity in human skin.
Qingyang Li, Zhenlai Zhu, +6 authors, Erle Dang.
Theranostics, 2021 May 18; 11(13). PMID: 33995668    Free PMC article.
A tyrosine kinase inhibitor-induced interferon response positively associates with clinical response in EGFR-mutant lung cancer.
Natalia J Gurule, Caroline E McCoach, +9 authors, Lynn E Heasley.
NPJ Precis Oncol, 2021 May 19; 5(1). PMID: 34001994    Free PMC article.
Organotypic Models of Lung Cancer.
Anna Pomerenke.
Curr Top Microbiol Immunol, 2018 Feb 10; 430. PMID: 29423618
Differentiation and Regulation of TH Cells: A Balancing Act for Cancer Immunotherapy.
Amrita Basu, Ganesan Ramamoorthi, +7 authors, Krithika Kodumudi.
Front Immunol, 2021 May 21; 12. PMID: 34012451    Free PMC article.
Review.
CXCL8 Associated Dendritic Cell Activation Marker Expression and Recruitment as Indicators of Favorable Outcomes in Colorectal Cancer.
Enhao Li, Xiaobao Yang, +7 authors, Yiqun Hu.
Front Immunol, 2021 May 25; 12. PMID: 34025668    Free PMC article.
Single-cell transcriptomics reveals the effect of PD-L1/TGF-β blockade on the tumor microenvironment.
Yoong Wearn Lim, Garry L Coles, +3 authors, Erica L Stone.
BMC Biol, 2021 May 26; 19(1). PMID: 34030676    Free PMC article.
MicroRNA-200c restoration reveals a cytokine profile to enhance M1 macrophage polarization in breast cancer.
Michelle M Williams, Jessica L Christenson, +5 authors, Jennifer K Richer.
NPJ Breast Cancer, 2021 May 29; 7(1). PMID: 34045467    Free PMC article.
Glycosylation of Immune Receptors in Cancer.
Ruoxuan Sun, Alyssa Min Jung Kim, Seung-Oe Lim.
Cells, 2021 Jun 03; 10(5). PMID: 34064396    Free PMC article.
Review.
Recent Progress in Dendritic Cell-Based Cancer Immunotherapy.
Kazuhiko Matsuo, Osamu Yoshie, +3 authors, Takashi Nakayama.
Cancers (Basel), 2021 Jun 03; 13(10). PMID: 34065346    Free PMC article.
Review.
Clinical Significance and Systematic Expression Analysis of the Thyroid Receptor Interacting Protein 13 (TRIP13) as Human Gliomas Biomarker.
Ssu-Han Chen, Hong-Han Lin, +2 authors, Dueng-Yuan Hueng.
Cancers (Basel), 2021 Jun 03; 13(10). PMID: 34066132    Free PMC article.
Clinical Application of Cytokines in Cancer Immunotherapy.
Yi Qiu, Mengxi Su, +3 authors, Jianbo Sun.
Drug Des Devel Ther, 2021 Jun 04; 15. PMID: 34079226    Free PMC article.
Review.
Eosinophilic inflammation promotes CCL6-dependent metastatic tumor growth.
Fei Li, Xufei Du, +12 authors, Huahao Shen.
Sci Adv, 2021 May 28; 7(22). PMID: 34039594    Free PMC article.
Tumor necroptosis is correlated with a favorable immune cell signature and programmed death-ligand 1 expression in cholangiocarcinoma.
Thanpisit Lomphithak, Perawatt Akara-Amornthum, +7 authors, Siriporn Jitkaew.
Sci Rep, 2021 Jun 05; 11(1). PMID: 34083572    Free PMC article.
Boosting immune surveillance by low-dose PI3K inhibitor facilitates early intervention of breast cancer.
Jinyang Wang, Yuan Zhang, +6 authors, Dihua Yu.
Am J Cancer Res, 2021 Jun 08; 11(5). PMID: 34094666    Free PMC article.