Landscape of Infiltrating T Cells in Liver Cancer Revealed by Single-Cell Sequencing

Chunhong Zheng ¹, Liangtao Zheng ², Jae-Kwang Yoo ³, Huahu Guo ⁴, Yuanyuan Zhang ¹, Xinyi Guo ¹, Boxi Kang ¹, Ruozhen Hu ³, Julie Y Huang ³, Qiming Zhang ¹, Zhouzerui Liu ¹, Minghui Dong ¹, Xueda Hu ¹, Wenjun Ouyang ⁵, Jirun Peng ⁶, Zemin Zhang ⁷

Affiliations

¹ BIOPIC, Beijing Advanced Innovation Center for Genomics, and School of Life Sciences, Peking University, Beijing 100871, China.
² Peking-Tsinghua Center for Life Sciences, Academy for Advanced Interdisciplinary Studies, Peking University, Beijing 100871, China.
³ Department of Inflammation and Oncology, Amgen Inc., South San Francisco, CA 94080, USA.
⁴ Department of Surgery, Beijing Shijitan Hospital, Capital Medical University, Beijing 100038, China; Ninth School of Clinical Medicine, Peking University, Beijing 100038, China; School of Oncology, Capital Medical University, Beijing 100038, China.
⁵ Department of Inflammation and Oncology, Amgen Inc., South San Francisco, CA 94080, USA. Electronic address: wouyang@amgen.com.
⁶ Department of Surgery, Beijing Shijitan Hospital, Capital Medical University, Beijing 100038, China; Ninth School of Clinical Medicine, Peking University, Beijing 100038, China; School of Oncology, Capital Medical University, Beijing 100038, China. Electronic address: pengjr@medmail.com.cn.
⁷ BIOPIC, Beijing Advanced Innovation Center for Genomics, and School of Life Sciences, Peking University, Beijing 100871, China; Peking-Tsinghua Center for Life Sciences, Academy for Advanced Interdisciplinary Studies, Peking University, Beijing 100871, China. Electronic address: zemin@pku.edu.cn.

PMID: 28622514
602 citations

Abstract

Systematic interrogation of tumor-infiltrating lymphocytes is key to the development of immunotherapies and the prediction of their clinical responses in cancers. Here, we perform deep single-cell RNA sequencing on 5,063 single T cells isolated from peripheral blood, tumor, and adjacent normal tissues from six hepatocellular carcinoma patients. The transcriptional profiles of these individual cells, coupled with assembled T cell receptor (TCR) sequences, enable us to identify 11 T cell subsets based on their molecular and functional properties and delineate their developmental trajectory. Specific subsets such as exhausted CD8+ T cells and Tregs are preferentially enriched and potentially clonally expanded in hepatocellular carcinoma (HCC), and we identified signature genes for each subset. One of the genes, layilin, is upregulated on activated CD8+ T cells and Tregs and represses the CD8+ T cell functions in vitro. This compendium of transcriptome data provides valuable insights and a rich resource for understanding the immune landscape in cancers.

Keywords: RNA-seq; T cell exhaustion; T cell receptor; bioinformatics; biomarkers; cancer immunology; hepatocellular carcinoma; immunotherapy; single-cell sequencing; tumor infiltrating lymphocytes.

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TIGIT Can Exert Immunosuppressive Effects on CD8+ T Cells by the CD155/TIGIT Signaling Pathway for Hepatocellular Carcinoma In Vitro. Changkun Zhang, Yang Wang, +7 authors, Jiye Zhu. less J Immunother, 2020 Aug 18; 43(8). PMID: 32804915 Free PMC article.
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Single-Cell RNA-Sequencing Shift in the Interaction Pattern Between Glioma Stem Cells and Immune Cells During Tumorigenesis. You Zhai, Guanzhang Li, +5 authors, Wei Zhang. less Front Immunol, 2020 Nov 03; 11. PMID: 33133100 Free PMC article.
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A pan-cancer blueprint of the heterogeneous tumor microenvironment revealed by single-cell profiling. Junbin Qian, Siel Olbrecht, +21 authors, Diether Lambrechts. less Cell Res, 2020 Jun 21; 30(9). PMID: 32561858 Free PMC article.
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Single-Cell Analysis of Different Stages of Oral Cancer Carcinogenesis in a Mouse Model. Ling-Yu Huang, Yi-Ping Hsieh, +6 authors, Tze-Ta Huang. less Int J Mol Sci, 2020 Nov 05; 21(21). PMID: 33142921 Free PMC article.
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Single-Cell RNA-Sequencing Identifies Activation of TP53 and STAT1 Pathways in Human T Lymphocyte Subpopulations in Response to Ex Vivo Radiation Exposure. Maria Moreno-Villanueva, Ye Zhang, +10 authors, Honglu Wu. less Int J Mol Sci, 2019 May 15; 20(9). PMID: 31083348 Free PMC article.
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Off-the-Shelf Allogeneic T Cell Therapies for Cancer: Opportunities and Challenges Using Naturally Occurring "Universal" Donor T Cells. Cynthia Perez, Isabelle Gruber, Caroline Arber. Front Immunol, 2020 Dec 03; 11. PMID: 33262761 Free PMC article. Review.
DSAVE: Detection of misclassified cells in single-cell RNA-Seq data. Johan Gustafsson, Jonathan Robinson, +3 authors, Jens Nielsen. less PLoS One, 2020 Dec 04; 15(12). PMID: 33270740 Free PMC article.
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Immune suppressive landscape in the human esophageal squamous cell carcinoma microenvironment. Yingxia Zheng, Zheyi Chen, +16 authors, Lisong Shen. less Nat Commun, 2020 Dec 10; 11(1). PMID: 33293583 Free PMC article.
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Global immune characterization of HBV/HCV-related hepatocellular carcinoma identifies macrophage and T-cell subsets associated with disease progression. Guohe Song, Yang Shi, +20 authors, Qiang Gao. less Cell Discov, 2020 Dec 11; 6(1). PMID: 33298893 Free PMC article.
Single-cell landscape of immunological responses in patients with COVID-19. Ji-Yuan Zhang, Xiang-Ming Wang, +18 authors, Fu-Sheng Wang. less Nat Immunol, 2020 Aug 14; 21(9). PMID: 32788748
A dynamic CD2-rich compartment at the outer edge of the immunological synapse boosts and integrates signals. Philippos Demetriou, Enas Abu-Shah, +20 authors, Michael L Dustin. less Nat Immunol, 2020 Sep 16; 21(10). PMID: 32929275 Free PMC article.
Discovery and Validation of a Metastasis-Related Prognostic and Diagnostic Biomarker for Melanoma Based on Single Cell and Gene Expression Datasets. Qi Wan, Chengxiu Liu, +3 authors, Chang Liu, Weiqin Liu, Xiaoran Wang, Zhichong Wang. less Front Oncol, 2020 Dec 17; 10. PMID: 33324561 Free PMC article.
Applications of Single-Cell Omics to Dissect Tumor Microenvironment. Tingting Guo, Weimin Li, Xuyu Cai. Front Genet, 2020 Dec 18; 11. PMID: 33329692 Free PMC article. Review.
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Association of inflammatory biomarkers with clinical outcomes in nivolumab-treated patients with advanced hepatocellular carcinoma. Bruno Sangro, Ignacio Melero, +12 authors, Anthony El-Khoueiry. less J Hepatol, 2020 Jul 28; 73(6). PMID: 32710922 Free PMC article.
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Statistical and Bioinformatics Analysis of Data from Bulk and Single-Cell RNA Sequencing Experiments. Xiaoqing Yu, Farnoosh Abbas-Aghababazadeh, Y Ann Chen, Brooke L Fridley. Methods Mol Biol, 2020 Sep 15; 2194. PMID: 32926366 Free PMC article. Review.
Comprehensive Integration of Single-Cell Transcriptional Profiling Reveals the Heterogeneities of Non-cardiomyocytes in Healthy and Ischemic Hearts. Lingfang Zhuang, Lin Lu, +2 authors, Ruiyan Zhang, Kang Chen, Xiaoxiang Yan. less Front Cardiovasc Med, 2020 Dec 29; 7. PMID: 33365332 Free PMC article.
Identification of Driver Genes Regulating the T-Cell-Infiltrating Levels in Hepatocellular Carcinoma. Yi Cai, Ying Tian, +8 authors, Zhengxia Yang. less Front Genet, 2021 Jan 01; 11. PMID: 33381145 Free PMC article.
Immunobiology and immunotherapy of HCC: spotlight on innate and innate-like immune cells. Benjamin Ruf, Bernd Heinrich, Tim F Greten. Cell Mol Immunol, 2020 Nov 26; 18(1). PMID: 33235387 Free PMC article. Review.
Specific MiRNAs in naïve T cells associated with Hepatitis C Virus-induced Hepatocellular Carcinoma. Peng Yan, Pengfei Pang, +7 authors, Junjie Mao. less J Cancer, 2021 Jan 05; 12(1). PMID: 33391397 Free PMC article.
Organized immune cell interactions within tumors sustain a productive T-cell response. Maria A Cardenas, Nataliya Prokhnevska, Haydn T Kissick. Int Immunol, 2020 Aug 23; 33(1). PMID: 32827212 Free PMC article. Review.
Hepatocellular carcinoma: old friends and new tricks. Eunsun Kim, Patrick Viatour. Exp Mol Med, 2020 Dec 04; 52(12). PMID: 33268834 Free PMC article. Review.
TISCH: a comprehensive web resource enabling interactive single-cell transcriptome visualization of tumor microenvironment. Dongqing Sun, Jin Wang, +13 authors, Chenfei Wang. less Nucleic Acids Res, 2020 Nov 13; 49(D1). PMID: 33179754 Free PMC article.
Tissue-Resident Lymphocytes: Implications in Immunotherapy for Hepatocellular Carcinoma. Ji Won Han, Seung Kew Yoon. Int J Mol Sci, 2021 Jan 01; 22(1). PMID: 33379384 Free PMC article. Review.
Integrative single-cell transcriptome analysis reveals a subpopulation of fibroblasts associated with favorable prognosis of liver cancer patients. Haiyang Wang, Chao Feng, +9 authors, Xuetao Pei. less Transl Oncol, 2021 Jan 06; 14(1). PMID: 33395744 Free PMC article.
A novel immune classification reveals distinct immune escape mechanism and genomic alterations: implications for immunotherapy in hepatocellular carcinoma. Zaoqu Liu, Yuyuan Zhang, +5 authors, Xinwei Han. less J Transl Med, 2021 Jan 08; 19(1). PMID: 33407585 Free PMC article.
Single-cell RNA Sequencing in Immunology. Yirui Cao, Yue Qiu, Guowei Tu, Cheng Yang. Curr Genomics, 2021 Jan 09; 21(8). PMID: 33414678 Free PMC article. Review.
T lymphocytes in hepatocellular carcinoma immune microenvironment: insights into human immunology and immunotherapy. Jin Bian, Jianzhen Lin, +5 authors, Haitao Zhao. less Am J Cancer Res, 2021 Jan 09; 10(12). PMID: 33415021 Free PMC article. Review.
Mapping the functional landscape of T cell receptor repertoires by single-T cell transcriptomics. Ze Zhang, Danyi Xiong, +2 authors, Xinlei Wang, Hongyu Liu, Tao Wang. less Nat Methods, 2021 Jan 08; 18(1). PMID: 33408405 Free PMC article.
Single-cell analysis reveals transcriptomic remodellings in distinct cell types that contribute to human prostate cancer progression. Sujun Chen, Guanghui Zhu, +30 authors, Shancheng Ren. less Nat Cell Biol, 2021 Jan 10; 23(1). PMID: 33420488
Optimal combination treatment regimens of vaccine and radiotherapy augment tumor-bearing host immunity. Fayun Zhang, Zifeng Zheng, +8 authors, Wei Liang. less Commun Biol, 2021 Jan 21; 4(1). PMID: 33469123 Free PMC article.
Differences in TCR repertoire and T cell activation underlie the divergent outcomes of antitumor immune responses in tumor-eradicating versus tumor-progressing hosts. Rachel A Woolaver, Xiaoguang Wang, +9 authors, Jing Hong Wang. less J Immunother Cancer, 2021 Jan 09; 9(1). PMID: 33414263 Free PMC article.
Hepatocellular carcinoma. Josep M Llovet, Robin Kate Kelley, +7 authors, Richard S Finn. less Nat Rev Dis Primers, 2021 Jan 23; 7(1). PMID: 33479224 Review.
Down-regulation of EOMES drives T-cell exhaustion via abolishing EOMES-mediated repression of inhibitory receptors of T cells in liver cancer. Hongwei He, Yong Yi, +4 authors, Shuangjian Qiu. less J Cell Mol Med, 2020 Dec 17; 25(1). PMID: 33325636 Free PMC article.
Systematic comparison of high-throughput single-cell RNA-seq methods for immune cell profiling. Tracy M Yamawaki, Daniel R Lu, +8 authors, Chi-Ming Li. less BMC Genomics, 2021 Jan 22; 22(1). PMID: 33472597 Free PMC article.
CXCL13 shapes immunoactive tumor microenvironment and enhances the efficacy of PD-1 checkpoint blockade in high-grade serous ovarian cancer. Moran Yang, Jiaqi Lu, +5 authors, Haiou Liu. less J Immunother Cancer, 2021 Jan 17; 9(1). PMID: 33452206 Free PMC article.
Single-cell analysis reveals the intra-tumor heterogeneity and identifies MLXIPL as a biomarker in the cellular trajectory of hepatocellular carcinoma. Xiao Dong, Fan Wang, +7 authors, Qi Li. less Cell Death Discov, 2021 Jan 20; 7(1). PMID: 33462196 Free PMC article.
Current concept for tertiary lymphoid structures in urothelial carcinoma of the bladder: a literature review and our experience. Milena Gulinac, Dorian Dikov, Simeon Lichev, Tsvetelina Velikova. Am J Clin Exp Immunol, 2021 Jan 26; 9(5). PMID: 33489474 Free PMC article. Review.
Opposing immune and genetic mechanisms shape oncogenic programs in synovial sarcoma. Livnat Jerby-Arnon, Cyril Neftel, +47 authors, Aviv Regev. less Nat Med, 2021 Jan 27; 27(2). PMID: 33495604 Free PMC article.
Mapping the immune environment in clear cell renal carcinoma by single-cell genomics. Nicholas Borcherding, Ajaykumar Vishwakarma, +7 authors, Weizhou Zhang. less Commun Biol, 2021 Jan 29; 4(1). PMID: 33504936 Free PMC article.
Understanding and Targeting Human Cancer Regulatory T Cells to Improve Therapy. H Ryan Kolb, Nicholas Borcherding, Weizhou Zhang. Adv Exp Med Biol, 2021 Feb 02; 1278. PMID: 33523451
PD-1 blockade-unresponsive human tumor-infiltrating CD8+ T cells are marked by loss of CD28 expression and rescued by IL-15. Kyung Hwan Kim, Hong Kwan Kim, +12 authors, Eui-Cheol Shin. less Cell Mol Immunol, 2020 Apr 26; 18(2). PMID: 32332901 Free PMC article.
Chemotherapeutic and targeted agents can modulate the tumor microenvironment and increase the efficacy of immune checkpoint blockades. Jun-Yan Li, Yu-Pei Chen, +2 authors, Ying-Qin Li, Na Liu, Jun Ma. less Mol Cancer, 2021 Feb 06; 20(1). PMID: 33541368 Free PMC article. Review.
Improving the Efficacy of Liver Cancer Immunotherapy: The Power of Combined Preclinical and Clinical Studies. Gen-Sheng Feng, Kaisa L Hanley, Yan Liang, Xiaoxue Lin. Hepatology, 2020 Jul 28; 73 Suppl 1. PMID: 32715491 Free PMC article. Review.
Development of a prognostic model based on an immunogenomic landscape analysis of medulloblastoma. Yuduo Guo, Shenglun Li, +2 authors, Peng Huang, Hongwei Zhang, Chunjiang Yu. less Biosci Rep, 2020 Dec 22; 41(1). PMID: 33345275 Free PMC article.
Mouse models illuminate MAIT cell biology. Huimeng Wang, Zhenjun Chen, James McCluskey, Alexandra J Corbett. Mol Immunol, 2020 Dec 29; 130. PMID: 33360377 Free PMC article. Review.
A Novel mRNA-miRNA Regulatory Sub-Network Associated With Prognosis of Metastatic Clear Cell Renal Cell Carcinoma. Tianyu Yang, Xiaofen Miao, +6 authors, Yongsheng Zhang. less Front Oncol, 2021 Feb 06; 10. PMID: 33542901 Free PMC article.
CD137+ T-Cells: Protagonists of the Immunotherapy Revolution. Alessio Ugolini, Marianna Nuti. Cancers (Basel), 2021 Feb 04; 13(3). PMID: 33530328 Free PMC article. Review.
Next Generation Imaging Techniques to Define Immune Topographies in Solid Tumors. Violena Pietrobon, Alessandra Cesano, Francesco Marincola, Jakob Nikolas Kather. Front Immunol, 2021 Feb 16; 11. PMID: 33584676 Free PMC article. Review.
Single-Cell Analysis Reveals Characterization of Infiltrating T Cells in Moderately Differentiated Colorectal Cancer. Xi Yang, Quan Qi, +6 authors, Shuwen Han. less Front Immunol, 2021 Feb 16; 11. PMID: 33584715 Free PMC article.
Development of a Metastasis-Related Immune Prognostic Model of Metastatic Colorectal Cancer and Its Usefulness to Immunotherapy. Zhiwen Luo, Xiao Chen, +8 authors, Xinyu Bi. less Front Cell Dev Biol, 2021 Feb 16; 8. PMID: 33585439 Free PMC article.
Dissecting transcriptional heterogeneity in primary gastric adenocarcinoma by single cell RNA sequencing. Min Zhang, Shuofeng Hu, +7 authors, Yan Liu. less Gut, 2020 Jun 14; 70(3). PMID: 32532891 Free PMC article.
Single-Cell RNA Sequencing Reveals the Expansion of Cytotoxic CD4+ T Lymphocytes and a Landscape of Immune Cells in Primary Sjögren's Syndrome. Xiaoping Hong, Shuhui Meng, +7 authors, Min Yang. less Front Immunol, 2021 Feb 20; 11. PMID: 33603736 Free PMC article.
Dynamics of thymus function and T cell receptor repertoire breadth in health and disease. David Granadier, Lorenzo Iovino, Sinéad Kinsella, Jarrod A Dudakov. Semin Immunopathol, 2021 Feb 21; 43(1). PMID: 33608819 Free PMC article. Review.
Advancing Cancer Research and Medicine with Single-Cell Genomics. Bora Lim, Yiyun Lin, Nicholas Navin. Cancer Cell, 2020 Apr 15; 37(4). PMID: 32289270 Free PMC article. Review.
Potential therapeutic targets in the tumor microenvironment of hepatocellular carcinoma: reversing the protumor effect of tumor-associated macrophages. Jingyi Zhou, Weiyu Wang, Qi Li. J Exp Clin Cancer Res, 2021 Feb 19; 40(1). PMID: 33596985 Free PMC article. Review.
Progress and Clinical Application of Single-Cell Transcriptional Sequencing Technology in Cancer Research. Jian Liu, Tianmin Xu, +2 authors, Yuemei Jin, Bingyu Huang, Yan Zhang. less Front Oncol, 2021 Feb 23; 10. PMID: 33614479 Free PMC article. Review.
IL-2 regulates tumor-reactive CD8+ T cell exhaustion by activating the aryl hydrocarbon receptor. Yuying Liu, Nannan Zhou, +24 authors, Bo Huang. less Nat Immunol, 2021 Jan 13; 22(3). PMID: 33432230
Pathophysiological Roles of Mucosal-Associated Invariant T Cells in the Context of Gut Microbiota-Liver Axis. Yoseph Asmelash Gebru, Mi Ran Choi, +7 authors, Ki Tae Suk. less Microorganisms, 2021 Feb 05; 9(2). PMID: 33535703 Free PMC article. Review.
Therapeutic depletion of CCR8+ tumor-infiltrating regulatory T cells elicits antitumor immunity and synergizes with anti-PD-1 therapy. Helena Van Damme, Bruno Dombrecht, +26 authors, Jo Agnes Van Ginderachter. less J Immunother Cancer, 2021 Feb 17; 9(2). PMID: 33589525 Free PMC article.
Blinatumomab-induced T cell activation at single cell transcriptome resolution. Yi Huo, Zhen Sheng, +6 authors, Ruibao Ren. less BMC Genomics, 2021 Mar 03; 22(1). PMID: 33648458 Free PMC article.
Single-cell qPCR Assay with Massively Parallel Microfluidic System. Marta Prieto-Vila, Takahiro Ochiya, Yusuke Yamamoto. Bio Protoc, 2021 Mar 05; 10(6). PMID: 33659534 Free PMC article.
Tumor methionine metabolism drives T-cell exhaustion in hepatocellular carcinoma. Man Hsin Hung, Joo Sang Lee, +11 authors, Xin Wei Wang. less Nat Commun, 2021 Mar 07; 12(1). PMID: 33674593 Free PMC article.
Inhibitory CD161 receptor identified in glioma-infiltrating T cells by single-cell analysis. Nathan D Mathewson, Orr Ashenberg, +37 authors, Kai W Wucherpfennig. less Cell, 2021 Feb 17; 184(5). PMID: 33592174 Free PMC article.
Circulating clonally expanded T cells reflect functions of tumor-infiltrating T cells. Liliana E Lucca, Pierre-Paul Axisa, +10 authors, David A Hafler. less J Exp Med, 2021 Mar 03; 218(4). PMID: 33651881 Free PMC article.
Single-cell differential splicing analysis reveals high heterogeneity of liver tumor-infiltrating T cells. Shang Liu, Biaofeng Zhou, +3 authors, Liang Wu, Yan Sun, Jie Chen, Shiping Liu. less Sci Rep, 2021 Mar 07; 11(1). PMID: 33674641 Free PMC article.
Advances in Human Immune System Mouse Models for Personalized Treg-Based Immunotherapies. Isabelle Serr, Maria Kral, Martin G Scherm, Carolin Daniel. Front Immunol, 2021 Mar 09; 12. PMID: 33679808 Free PMC article. Review.
An Unconventional View of T Cell Reconstitution After Allogeneic Hematopoietic Cell Transplantation. Hana Andrlová, Marcel R M van den Brink, Kate A Markey. Front Oncol, 2021 Mar 09; 10. PMID: 33680931 Free PMC article. Review.
Proteolysis-targeting chimera against BCL-XL destroys tumor-infiltrating regulatory T cells. Ryan Kolb, Umasankar De, +16 authors, Weizhou Zhang. less Nat Commun, 2021 Feb 26; 12(1). PMID: 33627663 Free PMC article.
Tumor-specific cytolytic CD4 T cells mediate immunity against human cancer. Amélie Cachot, Mariia Bilous, +22 authors, Camilla Jandus. less Sci Adv, 2021 Feb 28; 7(9). PMID: 33637530 Free PMC article.
Circulating mucosal-associated invariant T cells identify patients responding to anti-PD-1 therapy. Sara De Biasi, Lara Gibellini, +16 authors, Andrea Cossarizza. less Nat Commun, 2021 Mar 17; 12(1). PMID: 33723257 Free PMC article.
Clinicopathological analysis of neoplastic PD-L1-positive EBV+ diffuse large B cell lymphoma, not otherwise specified, in a Japanese cohort. Taishi Takahara, Akira Satou, +8 authors, Shigeo Nakamura. less Virchows Arch, 2020 Aug 18; 478(3). PMID: 32803453
Leveraging Single-Cell Approaches in Cancer Precision Medicine. Aritro Nath, Andrea H Bild. Trends Cancer, 2021 Feb 11; 7(4). PMID: 33563578 Free PMC article. Review.
Dynamics in protein translation sustaining T cell preparedness. Tobias Wolf, Wenjie Jin, +16 authors, Roger Geiger. less Nat Immunol, 2020 Jul 08; 21(8). PMID: 32632289 Free PMC article.
Global DNA hypermethylation pattern and unique gene expression signature in liver cancer from patients with Indigenous American ancestry. Juan Pablo Cerapio, Agnès Marchio, +8 authors, Pascal Pineau. less Oncotarget, 2021 Mar 23; 12(5). PMID: 33747361 Free PMC article.
Mixed Distribution Models Based on Single-Cell RNA Sequencing Data. Min Wu, Junhua Xu, Tao Ding, Jie Gao. Interdiscip Sci, 2021 Mar 24; 13(3). PMID: 33754241
Single-Cell Sequencing, an Advanced Technology in Lung Cancer Research. Hao Wang, Die Meng, +14 authors, Yayi He. less Onco Targets Ther, 2021 Mar 25; 14. PMID: 33758510 Free PMC article. Review.
Identification of tumor mutation burden-related hub genes and the underlying mechanism in melanoma. Chuan Zhang, Dan Dang, +2 authors, Chenlu Liu, Yuqian Wang, Xianling Cong. less J Cancer, 2021 Mar 25; 12(8). PMID: 33758620 Free PMC article.
Leveraging Single-Cell RNA-seq Data to Uncover the Association Between Cell Type and Chronic Liver Diseases. Xiangyu Ye, Julong Wei, +7 authors, Rongbin Yu. less Front Genet, 2021 Mar 26; 12. PMID: 33763117 Free PMC article.
The architectural design of CD8+ T cell responses in acute and chronic infection: Parallel structures with divergent fates. H Kay Chung, Bryan McDonald, Susan M Kaech. J Exp Med, 2021 Mar 24; 218(4). PMID: 33755719 Free PMC article. Review.
SLC1A4: A Powerful Prognostic Marker and Promising Therapeutic Target for HCC. Xiaozhen Peng, Ruochan Chen, +2 authors, Shenglan Cai, Shanshan Lu, Yiya Zhang. less Front Oncol, 2021 Mar 30; 11. PMID: 33777811 Free PMC article.
A new antisarcoma strategy: multisubtype heat shock protein/peptide immunotherapy combined with PD-L1 immunological checkpoint inhibitors. H Li, X Sui, +6 authors, Q Guo. less Clin Transl Oncol, 2021 Apr 02; 23(8). PMID: 33792840 Free PMC article.
A dual immune signature of CD8+ T cells and MMP9 improves the survival of patients with hepatocellular carcinoma. Huan Ding, Huan Hu, Feifei Tian, Huaping Liang. Biosci Rep, 2021 Mar 04; 41(3). PMID: 33656546 Free PMC article.
Hepatocellular Carcinoma Immune Landscape and the Potential of Immunotherapies. Julie Giraud, Domitille Chalopin, Jean-Frédéric Blanc, Maya Saleh. Front Immunol, 2021 Apr 06; 12. PMID: 33815418 Free PMC article. Review.
Phenotyping of immune and endometrial epithelial cells in endometrial carcinomas revealed by single-cell RNA sequencing. Yu-E Guo, Yiran Li, +6 authors, Qin Yan. less Aging (Albany NY), 2021 Jan 12; 13(5). PMID: 33429363 Free PMC article.
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Novel approaches to liver disease diagnosis and modeling. André G Oliveira, Romina Fiorotto. Transl Gastroenterol Hepatol, 2021 Apr 08; 6. PMID: 33824923 Free PMC article. Review.
Decoding Cancer Biology One Cell at a Time. L Nicolas Gonzalez Castro, Itay Tirosh, Mario L Suvà. Cancer Discov, 2021 Apr 04; 11(4). PMID: 33811126 Free PMC article. Review.
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Atlas of breast cancer infiltrated B-lymphocytes revealed by paired single-cell RNA-sequencing and antigen receptor profiling. Qingtao Hu, Yu Hong, +10 authors, Yu Zhang. less Nat Commun, 2021 Apr 14; 12(1). PMID: 33846305 Free PMC article.
Single-cell technologies in hepatology: new insights into liver biology and disease pathogenesis. Prakash Ramachandran, Kylie P Matchett, +2 authors, Ross Dobie, John R Wilson-Kanamori, Neil C Henderson. less Nat Rev Gastroenterol Hepatol, 2020 Jun 03; 17(8). PMID: 32483353 Review.
Predicting recognition between T cell receptors and epitopes with TCRGP. Emmi Jokinen, Jani Huuhtanen, +2 authors, Satu Mustjoki, Markus Heinonen, Harri Lähdesmäki. less PLoS Comput Biol, 2021 Mar 26; 17(3). PMID: 33764977 Free PMC article.
A novel panel based on immune infiltration and tumor mutational burden for prognostic prediction in hepatocellular carcinoma. Chan Xie, Hewei Wu, +6 authors, Liang Peng. less Aging (Albany NY), 2021 Mar 14; 13(6). PMID: 33714200 Free PMC article.
High-dimensional analysis of the adenosine pathway in high-grade serous ovarian cancer. Yacine Bareche, Sandra Pommey, +11 authors, John Stagg. less J Immunother Cancer, 2021 Mar 28; 9(3). PMID: 33771891 Free PMC article.
Single-cell RNA-seq reveals dynamic change in tumor microenvironment during pancreatic ductal adenocarcinoma malignant progression. Kai Chen, Qi Wang, +5 authors, Yinmo Yang. less EBioMedicine, 2021 Apr 06; 66. PMID: 33819739 Free PMC article.
Lineage-dependent gene expression programs influence the immune landscape of colorectal cancer. Hae-Ock Lee, Yourae Hong, +34 authors, Woong-Yang Park. less Nat Genet, 2020 May 27; 52(6). PMID: 32451460
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Single-cell sequencing techniques from individual to multiomics analyses. Yukie Kashima, Yoshitaka Sakamoto, +3 authors, Ayako Suzuki. less Exp Mol Med, 2020 Sep 16; 52(9). PMID: 32929221 Free PMC article. Review.
Single-cell transcriptomics in cancer: computational challenges and opportunities. Jean Fan, Kamil Slowikowski, Fan Zhang. Exp Mol Med, 2020 Sep 16; 52(9). PMID: 32929226 Free PMC article. Review.
Activated Regulatory T-Cells, Dysfunctional and Senescent T-Cells Hinder the Immunity in Pancreatic Cancer. Shivan Sivakumar, Enas Abu-Shah, +13 authors, Michael L Dustin. less Cancers (Basel), 2021 May 01; 13(8). PMID: 33917832 Free PMC article.
RNA Flow Cytometry for the Study of T Cell Metabolism. Alessandra Rossi, Ilenia Pacella, Silvia Piconese. Int J Mol Sci, 2021 May 01; 22(8). PMID: 33918901 Free PMC article. Review.
Immune Checkpoints in Pediatric Solid Tumors: Targetable Pathways for Advanced Therapeutic Purposes. Claudia Cocco, Fabio Morandi, Irma Airoldi. Cells, 2021 May 01; 10(4). PMID: 33920505 Free PMC article. Review.
Anti-PD-1/PD-L1 Based Combination Immunotherapy to Boost Antigen-Specific CD8+ T Cell Response in Hepatocellular Carcinoma. Julia Peña-Asensio, Henar Calvo, +3 authors, Juan-Ramón Larrubia. less Cancers (Basel), 2021 May 01; 13(8). PMID: 33923463 Free PMC article. Review.
Recruitment and Expansion of Tregs Cells in the Tumor Environment-How to Target Them? Justine Cinier, Margaux Hubert, +5 authors, Christine Ménétrier-Caux. less Cancers (Basel), 2021 May 01; 13(8). PMID: 33924428 Free PMC article. Review.
Monitoring T Cells Responses Mounted by Therapeutic Cancer Vaccines. Kue Peng Lim, Nur Syafinaz Zainal. Front Mol Biosci, 2021 May 04; 8. PMID: 33937323 Free PMC article. Review.
Severely ill COVID-19 patients display impaired exhaustion features in SARS-CoV-2-reactive CD8+ T cells. Anthony Kusnadi, Ciro Ramírez-Suástegui, +8 authors, Christian H Ottensmeier. less Sci Immunol, 2021 Jan 23; 6(55). PMID: 33478949 Free PMC article.
STARTRAC analyses of scRNAseq data from tumor models reveal T cell dynamics and therapeutic targets. Dev Bhatt, Boxi Kang, +13 authors, Wenjun Ouyang. less J Exp Med, 2021 Apr 27; 218(6). PMID: 33900375 Free PMC article.
Single-Cell TCR Sequencing Reveals the Dynamics of T Cell Repertoire Profiling During Pneumocystis Infection. Hu-Qin Yang, Yi-Shan Wang, Kan Zhai, Zhao-Hui Tong. Front Microbiol, 2021 May 08; 12. PMID: 33959105 Free PMC article.
Conserved human effector Treg cell transcriptomic and epigenetic signature in arthritic joint inflammation. Gerdien Mijnheer, Lisanne Lutter, +16 authors, Femke van Wijk. less Nat Commun, 2021 May 13; 12(1). PMID: 33976194 Free PMC article.
TRIM68, PIKFYVE, and DYNLL2: The Possible Novel Autophagy- and Immunity-Associated Gene Biomarkers for Osteosarcoma Prognosis. Jie Jiang, Dachang Liu, +18 authors, Xinli Zhan. less Front Oncol, 2021 May 11; 11. PMID: 33968741 Free PMC article.
What are the applications of single-cell RNA sequencing in cancer research: a systematic review. Lvyuan Li, Fang Xiong, +15 authors, Can Guo. less J Exp Clin Cancer Res, 2021 May 13; 40(1). PMID: 33975628 Free PMC article. Systematic Review.
Targeting human Acyl-CoA:cholesterol acyltransferase as a dual viral and T cell metabolic checkpoint. Nathalie M Schmidt, Peter A C Wing, +18 authors, Mala K Maini. less Nat Commun, 2021 May 16; 12(1). PMID: 33990561 Free PMC article.
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Poor clinical outcomes and immunoevasive contexture in CXCL13+CD8+ T cells enriched gastric cancer patients. Kaifeng Jin, Yifan Cao, +13 authors, Jiejie Xu. less Oncoimmunology, 2021 May 18; 10(1). PMID: 33996266 Free PMC article.
Longitudinal single-cell profiling reveals molecular heterogeneity and tumor-immune evolution in refractory mantle cell lymphoma. Shaojun Zhang, Vivian Changying Jiang, +34 authors, Michael Wang. less Nat Commun, 2021 May 19; 12(1). PMID: 34001881 Free PMC article.
Deciphering Tumor Heterogeneity in Hepatocellular Carcinoma (HCC)-Multi-Omic and Singulomic Approaches. Renumathy Dhanasekaran. Semin Liver Dis, 2021 Mar 26; 41(1). PMID: 33764481 Free PMC article. Review.
Clonally expanded EOMES+ Tr1-like cells in primary and metastatic tumors are associated with disease progression. Raoul J P Bonnal, Grazisa Rossetti, +43 authors, Massimiliano Pagani. less Nat Immunol, 2021 May 22; 22(6). PMID: 34017124
Progressive immune dysfunction with advancing disease stage in renal cell carcinoma. David A Braun, Kelly Street, +32 authors, Catherine J Wu. less Cancer Cell, 2021 Mar 13; 39(5). PMID: 33711273 Free PMC article.
Pseudocell Tracer-A method for inferring dynamic trajectories using scRNAseq and its application to B cells undergoing immunoglobulin class switch recombination. Derek Reiman, Godhev Kumar Manakkat Vijay, +5 authors, Aly A Khan. less PLoS Comput Biol, 2021 May 04; 17(5). PMID: 33939691 Free PMC article.
Single-cell RNA sequencing in cancer: Applications, advances, and emerging challenges. Guangshun Sun, Zhouxiao Li, +9 authors, Yangbai Sun. less Mol Ther Oncolytics, 2021 May 25; 21. PMID: 34027052 Free PMC article. Review.
CDSeqR: fast complete deconvolution for gene expression data from bulk tissues. Kai Kang, Caizhi Huang, +2 authors, Yuanyuan Li, David M Umbach, Leping Li. less BMC Bioinformatics, 2021 May 26; 22(1). PMID: 34030626 Free PMC article.
The Crosstalk Between Cancer Cells and Neutrophils Enhances Hepatocellular Carcinoma Metastasis via Neutrophil Extracellular Traps-Associated Cathepsin G Component: A Potential Therapeutic Target. Xiangqian Guan, Yuyan Lu, +5 authors, Zhenyu Yin. less J Hepatocell Carcinoma, 2021 May 29; 8. PMID: 34046369 Free PMC article.
Resolving the graft ischemia-reperfusion injury during liver transplantation at the single cell resolution. Linhe Wang, Jie Li, +12 authors, Xiaoshun He. less Cell Death Dis, 2021 Jun 10; 12(6). PMID: 34103479 Free PMC article.
Applications of single-cell sequencing in cancer research: progress and perspectives. Yalan Lei, Rong Tang, +5 authors, Si Shi. less J Hematol Oncol, 2021 Jun 11; 14(1). PMID: 34108022 Free PMC article. Review.
Combination of molecularly targeted therapies and immune checkpoint inhibitors in the new era of unresectable hepatocellular carcinoma treatment. Ze-Long Liu, Jing-Hua Liu, Daniel Staiculescu, Jiang Chen. Ther Adv Med Oncol, 2021 Jun 10; 13. PMID: 34104226 Free PMC article. Review.
The Endless Sources of Hepatocellular Carcinoma Heterogeneity. Marina Barcena-Varela, Amaia Lujambio. Cancers (Basel), 2021 Jun 03; 13(11). PMID: 34073538 Free PMC article. Review.
Single-cell biology to decode the immune cellular composition of kidney inflammation. Yu Zhao, Ulf Panzer, Stefan Bonn, Christian F Krebs. Cell Tissue Res, 2021 Jun 15; 385(2). PMID: 34125286 Free PMC article. Review.
Identification METTL18 as a Potential Prognosis Biomarker and Associated With Immune Infiltrates in Hepatocellular Carcinoma. Tian-Hao Li, Cheng Qin, +6 authors, Wei-Bin Wang. less Front Oncol, 2021 Jun 15; 11. PMID: 34123827 Free PMC article.
Maintenance of the human memory T cell repertoire by subset and tissue site. Michelle Miron, Wenzhao Meng, +7 authors, Donna L Farber. less Genome Med, 2021 Jun 16; 13(1). PMID: 34127056 Free PMC article.
Single-cell RNA sequencing shows the immunosuppressive landscape and tumor heterogeneity of HBV-associated hepatocellular carcinoma. Daniel Wai-Hung Ho, Yu-Man Tsui, +14 authors, Irene Oi-Lin Ng. less Nat Commun, 2021 Jun 19; 12(1). PMID: 34140495 Free PMC article.
Signatures of B Cell Receptor Repertoire Following Pneumocystis Infection. Han Sun, Hu-Qin Yang, Kan Zhai, Zhao-Hui Tong. Front Microbiol, 2021 Jun 18; 12. PMID: 34135870 Free PMC article.
Neuromedin U and neurotensin may promote the development of the tumour microenvironment in neuroblastoma. Daheng Yang, Xianwei Zhang, +3 authors, Zheqian Li, Fei Xu, Chenjie Tang, Hongbing Chen. less PeerJ, 2021 Jun 19; 9. PMID: 34141479 Free PMC article.
Liver Cancer Immunity. Sumera Rizvi, Juan Wang, Anthony B El-Khoueiry. Hepatology, 2020 Jun 10; 73 Suppl 1. PMID: 32516437 Free PMC article. Review.
Recent Advancements in Nanomedicine for 'Cold' Tumor Immunotherapy. Qinjun Chen, Tao Sun, Chen Jiang. Nanomicro Lett, 2021 Jun 18; 13(1). PMID: 34138315 Free PMC article. Review.
Single-cell transcriptomic analysis reveals disparate effector differentiation pathways in human Treg compartment. Yuechen Luo, Changlu Xu, +18 authors, Xiaoming Feng. less Nat Commun, 2021 Jun 25; 12(1). PMID: 34162888 Free PMC article.
Exploring liver cancer biology through functional genetic screens. Cun Wang, Ying Cao, +2 authors, Chen Yang, René Bernards, Wenxin Qin. less Nat Rev Gastroenterol Hepatol, 2021 Jun 25; 18(10). PMID: 34163045 Review.
Peripheral CD8+ T cell characteristics associated with durable responses to immune checkpoint blockade in patients with metastatic melanoma. Benjamin P Fairfax, Chelsea A Taylor, +12 authors, Mark R Middleton. less Nat Med, 2020 Feb 12; 26(2). PMID: 32042196 Free PMC article.
Single-Cell TCR and Transcriptome Analysis: An Indispensable Tool for Studying T-Cell Biology and Cancer Immunotherapy. Anna Pasetto, Yong-Chen Lu. Front Immunol, 2021 Jun 25; 12. PMID: 34163487 Free PMC article. Review.
Intratumoral follicular regulatory T cells curtail anti-PD-1 treatment efficacy. Simon Eschweiler, James Clarke, +14 authors, Pandurangan Vijayanand. less Nat Immunol, 2021 Jun 26; 22(8). PMID: 34168370 Free PMC article.
Natural Killer Cells and T Cells in Hepatocellular Carcinoma and Viral Hepatitis: Current Status and Perspectives for Future Immunotherapeutic Approaches. Suresh Gopi Kalathil, Yasmin Thanavala. Cells, 2021 Jun 03; 10(6). PMID: 34071188 Free PMC article. Review.
Single-cell atlas of colonic CD8+ T cells in ulcerative colitis. Daniele Corridoni, Agne Antanaviciute, +17 authors, Alison Simmons. less Nat Med, 2020 Aug 05; 26(9). PMID: 32747828
Applications of Single-Cell Omics in Tumor Immunology. Junwei Liu, Saisi Qu, +5 authors, Weiwei Yin. less Front Immunol, 2021 Jun 29; 12. PMID: 34177965 Free PMC article. Review.
Single-Cell Transcriptomics Reveals the Cellular Heterogeneity of Cardiovascular Diseases. Mengxia Fu, Jiangping Song. Front Cardiovasc Med, 2021 Jun 29; 8. PMID: 34179129 Free PMC article. Review.
Resident and circulating memory T cells persist for years in melanoma patients with durable responses to immunotherapy. Jichang Han, Yanding Zhao, +12 authors, Christina V Angeles. less Nat Cancer, 2021 Jun 29; 2(3). PMID: 34179824 Free PMC article.
Immune signature-based hepatocellular carcinoma subtypes may provide novel insights into therapy and prognosis predictions. Qiuxian Zheng, Qin Yang, +5 authors, Zhi Chen. less Cancer Cell Int, 2021 Jul 02; 21(1). PMID: 34193146 Free PMC article.
An Immune-Related Prognostic Classifier Is Associated with Diffuse Large B Cell Lymphoma Microenvironment. Xiao-Jie Liang, Rui-Ying Fu, +4 authors, Liang Wang. less J Immunol Res, 2021 Jul 03; 2021. PMID: 34212052 Free PMC article.
Discovering Cellular Mitochondrial Heteroplasmy Heterogeneity with Single Cell RNA and ATAC Sequencing. Aidan S Marshall, Nick S Jones. Biology (Basel), 2021 Jul 03; 10(6). PMID: 34198745 Free PMC article. Review.
Novel Prognostic Biomarkers in Gastric Cancer: CGB5, MKNK2, and PAPPA2. Min Qin, Zhihai Liang, +4 authors, Guodu Tang. less Front Oncol, 2021 Jul 06; 11. PMID: 34222004 Free PMC article.
Single-cell chromatin accessibility landscape of human umbilical cord blood in trisomy 18 syndrome. Xiaofen Qiu, Haiyan Yu, +11 authors, Yong Dai. less Hum Genomics, 2021 Jul 02; 15(1). PMID: 34193281 Free PMC article.
Bardet-Biedl syndrome proteins regulate intracellular signaling and neuronal function in patient-specific iPSC-derived neurons. Liheng Wang, Yang Liu, +16 authors, Rudolph L Leibel. less J Clin Invest, 2021 Feb 26; 131(8). PMID: 33630762 Free PMC article.
An m6A-Related Prognostic Biomarker Associated With the Hepatocellular Carcinoma Immune Microenvironment. Yingxi Du, Yarui Ma, +4 authors, Xiaobing Wang. less Front Pharmacol, 2021 Jul 13; 12. PMID: 34248650 Free PMC article.
ASRGL1 Correlates With Immune Cell Infiltration in Hepatocellular Carcinoma and Can Serve as a Prognostic Biomarker. Cailin Xue, Peng Gao, +5 authors, Xihu Qin. less Front Oncol, 2021 Jul 13; 11. PMID: 34249720 Free PMC article.
CD8+ T cell differentiation and dysfunction in cancer. Mary Philip, Andrea Schietinger. Nat Rev Immunol, 2021 Jul 14; 22(4). PMID: 34253904 Review.
Predictive potential of Nomogram based on GMWG for patients with hepatocellular carcinoma after radical resection. Liying Ren, Dongbo Chen, +6 authors, Weijia Liao. less BMC Cancer, 2021 Jul 17; 21(1). PMID: 34266388 Free PMC article.
Construction and validation of a prognostic signature using CNV-driven genes for hepatocellular carcinoma. Jin Bian, Junyu Long, +6 authors, Haitao Zhao. less Ann Transl Med, 2021 Jul 17; 9(9). PMID: 34268378 Free PMC article.
Bulk and single-cell transcriptome profiling reveal the metabolic heterogeneity in human breast cancers. Tian-Jian Yu, Ding Ma, +6 authors, Gen-Hong Di. less Mol Ther, 2021 Mar 08; 29(7). PMID: 33677091 Free PMC article.
M2 macrophage-derived extracellular vesicles facilitate CD8+T cell exhaustion in hepatocellular carcinoma via the miR-21-5p/YOD1/YAP/β-catenin pathway. Jian Pu, Zuoming Xu, +7 authors, Huamei Wei. less Cell Death Discov, 2021 Jul 21; 7(1). PMID: 34282135 Free PMC article.
Pivotal factors associated with the immunosuppressive tumor microenvironment and melanoma metastasis. Chuan Zhang, Dan Dang, +2 authors, Lele Cong, Hongyan Sun, Xianling Cong. less Cancer Med, 2021 Jun 24; 10(14). PMID: 34159752 Free PMC article.
Prospects and Challenges for T Cell-Based Therapies of HCC. Norman Woller, Sophie Anna Engelskircher, Thomas Wirth, Heiner Wedemeyer. Cells, 2021 Jul 03; 10(7). PMID: 34209393 Free PMC article. Review.
Antigen identification for HLA class I- and HLA class II-restricted T cell receptors using cytokine-capturing antigen-presenting cells. Mark N Lee, Matthew Meyerson. Sci Immunol, 2021 Jan 24; 6(55). PMID: 33483338 Free PMC article.
Genomic and transcriptomic profiling of hepatoid adenocarcinoma of the stomach. Ziyang Liu, Anqiang Wang, +8 authors, Jiafu Ji. less Oncogene, 2021 Jul 31; 40(38). PMID: 34326469
MAIT cells regulate NK cell-mediated tumor immunity. Emma V Petley, Hui-Fern Koay, +28 authors, Phillip K Darcy. less Nat Commun, 2021 Aug 08; 12(1). PMID: 34362900 Free PMC article.
Insights into an Immunotherapeutic Approach to Combat Multidrug Resistance in Hepatocellular Carcinoma. Aswathy R Devan, Ayana R Kumar, +5 authors, Lekshmi R Nath. less Pharmaceuticals (Basel), 2021 Aug 07; 14(7). PMID: 34358082 Free PMC article. Review.
Role of Oncogenic Pathways on the Cancer Immunosuppressive Microenvironment and Its Clinical Implications in Hepatocellular Carcinoma. Naoshi Nishida. Cancers (Basel), 2021 Aug 08; 13(15). PMID: 34359568 Free PMC article. Review.
Antigen-Specific Treg Therapy in Type 1 Diabetes - Challenges and Opportunities. Isabelle Serr, Felix Drost, Benjamin Schubert, Carolin Daniel. Front Immunol, 2021 Aug 10; 12. PMID: 34367177 Free PMC article. Review.
Immunotherapy against programmed death-1/programmed death ligand 1 in hepatocellular carcinoma: Importance of molecular variations, cellular heterogeneity, and cancer stem cells. Caecilia H C Sukowati, Korri Elvanita El-Khobar, Claudio Tiribelli. World J Stem Cells, 2021 Aug 10; 13(7). PMID: 34367478 Free PMC article. Review.
Cellular based immunotherapy for primary liver cancer. Yuanyuan Zheng, Yan Li, +8 authors, Chuanyong Guo. less J Exp Clin Cancer Res, 2021 Aug 11; 40(1). PMID: 34372912 Free PMC article. Review.
Interleukin-2 inducible T-cell kinase: a potential prognostic biomarker and tumor microenvironment remodeling indicator for hepatocellular carcinoma. Binhua Pan, Modan Yang, +7 authors, Xiao Xu. less Aging (Albany NY), 2021 Jul 21; 13(14). PMID: 34282055 Free PMC article.
Human MAIT cells endowed with HBV specificity are cytotoxic and migrate towards HBV-HCC while retaining antimicrobial functions. Katie Healy, Andrea Pavesi, +8 authors, Margaret Sällberg Chen. less JHEP Rep, 2021 Aug 12; 3(4). PMID: 34377970 Free PMC article.
Single-Cell RNA Sequencing of Retina:New Looks for Gene Marker and Old Diseases. Peixi Ying, Chang Huang, +7 authors, Min Fu. less Front Mol Biosci, 2021 Aug 17; 8. PMID: 34395530 Free PMC article. Review.
Immune suppressive checkpoint interactions in the tumour microenvironment of primary liver cancers. Guoying Zhou, Patrick P C Boor, +2 authors, Marco J Bruno, Dave Sprengers, Jaap Kwekkeboom. less Br J Cancer, 2021 Aug 18; 126(1). PMID: 34400801 Free PMC article. Review.
Cancer biology deciphered by single-cell transcriptomic sequencing. Yanmeng Li, Jianshi Jin, Fan Bai. Protein Cell, 2021 Aug 19; 13(3). PMID: 34405376 Free PMC article. Review.
Inferring single cell expression profiles from overlapped pooling sequencing data with compressed sensing strategy. Mengting Huang, Yixuan Yang, +5 authors, Zuhong Lu. less Nucleic Acids Res, 2021 Jul 11; 49(14). PMID: 34244789 Free PMC article.
MultiK: an automated tool to determine optimal cluster numbers in single-cell RNA sequencing data. Siyao Liu, Aatish Thennavan, +2 authors, Joseph P Garay, J S Marron, Charles M Perou. less Genome Biol, 2021 Aug 21; 22(1). PMID: 34412669 Free PMC article.
HHLA2 Expression is Associated with Poor Survival in Patients with Hepatocellular Carcinoma. Yituo Xu, Zhijie Huang, +3 authors, Jing Xu. less Biologics, 2021 Aug 21; 15. PMID: 34413629 Free PMC article.
Exploring Markers of Exhausted CD8 T Cells to Predict Response to Immune Checkpoint Inhibitor Therapy for Hepatocellular Carcinoma. Chia-Lang Hsu, Da-Liang Ou, +6 authors, Chiun Hsu. less Liver Cancer, 2021 Aug 21; 10(4). PMID: 34414122 Free PMC article.
Technological advances in cancer immunity: from immunogenomics to single-cell analysis and artificial intelligence. Ying Xu, Guan-Hua Su, +3 authors, Ding Ma, Yi Xiao, Zhi-Ming Shao, Yi-Zhou Jiang. less Signal Transduct Target Ther, 2021 Aug 22; 6(1). PMID: 34417437 Free PMC article. Review.
Integrating T cell receptor sequences and transcriptional profiles by clonotype neighbor graph analysis (CoNGA). Stefan A Schattgen, Kate Guion, +5 authors, Philip Bradley. less Nat Biotechnol, 2021 Aug 25; 40(1). PMID: 34426704 Free PMC article.
Single-Cell Profiling Explore the Immunologic Mechanisms of Tumor Relapse in Hepatocellular Carcinoma. Liyi Zhang. Glob Med Genet, 2021 Aug 26; 8(3). PMID: 34430957 Free PMC article.
Comprehensive Analyses of the Infiltrating Immune Cell Landscape and Its Clinical Significance in Hepatocellular Carcinoma. Zeyu Zhang, Zhiming Wang, Yun Huang. Int J Gen Med, 2021 Aug 28; 14. PMID: 34447264 Free PMC article.
IgG Immune Complexes Inhibit Naïve T Cell Proliferation and Suppress Effector Function in Cytotoxic T Cells. Wissam Charab, Matthew G Rosenberger, +8 authors, George Georgiou. less Front Immunol, 2021 Aug 28; 12. PMID: 34447380 Free PMC article.
Tissue-Resident T Cells in Chronic Relapsing-Remitting Intestinal Disorders. Juliana Barreto de Albuquerque, Christoph Mueller, Bilgi Gungor. Cells, 2021 Aug 28; 10(8). PMID: 34440651 Free PMC article. Review.
The State of Immunotherapy in Hepatobiliary Cancers. Farhan Z Ilyas, Joal D Beane, Timothy M Pawlik. Cells, 2021 Aug 28; 10(8). PMID: 34440865 Free PMC article. Review.
From bench to bedside: Single-cell analysis for cancer immunotherapy. Emily F Davis-Marcisak, Atul Deshpande, +5 authors, Luciane T Kagohara. less Cancer Cell, 2021 Jul 31; 39(8). PMID: 34329587 Free PMC article. Review.
Applying high-dimensional single-cell technologies to the analysis of cancer immunotherapy. Satyen H Gohil, J Bryan Iorgulescu, +2 authors, David A Braun, Derin B Keskin, Kenneth J Livak. less Nat Rev Clin Oncol, 2020 Dec 06; 18(4). PMID: 33277626 Free PMC article. Review.
B-Cell Compartmental Features and Molecular Basis for Therapy in Autoimmune Disease. Chao Zhang, Tian-Xiang Zhang, +7 authors, Fu-Dong Shi. less Neurol Neuroimmunol Neuroinflamm, 2021 Sep 02; 8(6). PMID: 34465614 Free PMC article.
A single-cell atlas of liver metastases of colorectal cancer reveals reprogramming of the tumor microenvironment in response to preoperative chemotherapy. Li-Heng Che, Jing-Wen Liu, +14 authors, Jian-Ming Li. less Cell Discov, 2021 Sep 08; 7(1). PMID: 34489408 Free PMC article.
Autoimmunity affecting the biliary tract fuels the immunosurveillance of cholangiocarcinoma. Juliette Paillet, Céleste Plantureux, +33 authors, Jonathan G Pol. less J Exp Med, 2021 Sep 09; 218(10). PMID: 34495298 Free PMC article.
Single-Cell RNA Sequencing Reveals the Migration of Osteoclasts in Giant Cell Tumor of Bone. Wenyu Feng, Mingwei He, +11 authors, Qingjun Wei. less Front Oncol, 2021 Sep 11; 11. PMID: 34504794 Free PMC article.
Genetic Heterogeneity, Therapeutic Hurdle Confronting Sorafenib and Immune Checkpoint Inhibitors in Hepatocellular Carcinoma. Sara M Atwa, Margarete Odenthal, Hend M El Tayebi. Cancers (Basel), 2021 Sep 11; 13(17). PMID: 34503153 Free PMC article. Review.
Identification and Characterization of Robust Hepatocellular Carcinoma Prognostic Subtypes Based on an Integrative Metabolite-Protein Interaction Network. Di Chen, Yiran Zhang, +17 authors, Hai-Long Piao. less Adv Sci (Weinh), 2021 Jul 12; 8(17). PMID: 34247449 Free PMC article.
Pan-cancer analysis and single-cell analysis revealed the role of ABCC5 transporter in hepatocellular carcinoma. Liang Chen, Zhonghua Yang, +6 authors, Hongzhu Yu. less Channels (Austin), 2021 Sep 09; 15(1). PMID: 34494510 Free PMC article.
Schrödinger's T Cells: Molecular Insights Into Stemness and Exhaustion. Nancy M Gonzalez, Dawei Zou, Andy Gu, Wenhao Chen. Front Immunol, 2021 Sep 14; 12. PMID: 34512656 Free PMC article. Review.
SCISSOR™: a single-cell inferred site-specific omics resource for tumor microenvironment association study. Xiang Cui, Fei Qin, +2 authors, Xuanxuan Yu, Feifei Xiao, Guoshuai Cai. less NAR Cancer, 2021 Sep 14; 3(3). PMID: 34514416 Free PMC article.
Advancing to the era of cancer immunotherapy. Yun Wang, Min Wang, Hao-Xiang Wu, Rui-Hua Xu. Cancer Commun (Lond), 2021 Jun 25; 41(9). PMID: 34165252 Free PMC article. Review.
GDF15 induces immunosuppression via CD48 on regulatory T cells in hepatocellular carcinoma. Zhaowei Wang, Lei He, +19 authors, Meng Li. less J Immunother Cancer, 2021 Sep 08; 9(9). PMID: 34489334 Free PMC article.
Biomarkers and Future Perspectives for Hepatocellular Carcinoma Immunotherapy. Yuqing He, Mengyao Lu, +3 authors, Jing Che, Qian Chu, Peng Zhang, Yuan Chen. less Front Oncol, 2021 Sep 24; 11. PMID: 34552872 Free PMC article. Review.
Mechanism of action of PD-1 receptor/ligand targeted cancer immunotherapy. Jannie Borst, Julia Busselaar, Douwe M T Bosma, Ferry Ossendorp. Eur J Immunol, 2021 Jun 10; 51(8). PMID: 34106465 Free PMC article. Review.
A preliminary investigation into the immune cell landscape of schistosome-associated liver fibrosis in humans. Yu Zhang, Junhui Li, +4 authors, Yingzi Ming. less Immunol Cell Biol, 2021 Aug 07; 99(8). PMID: 34355810 Free PMC article.
Systematic investigation of cytokine signaling activity at the tissue and single-cell levels. Peng Jiang, Yu Zhang, +9 authors, Kai W Wucherpfennig. less Nat Methods, 2021 Oct 02; 18(10). PMID: 34594031 Free PMC article.
CD177 modulates the function and homeostasis of tumor-infiltrating regulatory T cells. Myung-Chul Kim, Nicholas Borcherding, +32 authors, Weizhou Zhang. less Nat Commun, 2021 Oct 03; 12(1). PMID: 34599187 Free PMC article.
Layilin Anchors Regulatory T Cells in Skin. Pooja Mehta, Victoire Gouirand, +20 authors, Michael D Rosenblum. less J Immunol, 2021 Sep 03; 207(7). PMID: 34470859 Free PMC article.
Immunotherapeutic Potential of T Memory Stem Cells. Yujie Li, Dengqiang Wu, Xuejia Yang, Sufang Zhou. Front Oncol, 2021 Oct 05; 11. PMID: 34604060 Free PMC article. Review.
The GPR171 pathway suppresses T cell activation and limits antitumor immunity. Yuki Fujiwara, Robert J Torphy, +8 authors, Yuwen Zhu. less Nat Commun, 2021 Oct 08; 12(1). PMID: 34615877 Free PMC article.
Human tissue cultures of lung cancer predict patient susceptibility to immune-checkpoint inhibition. David Junk, Sebastian Krämer, +10 authors, Sonja Kallendrusch. less Cell Death Discov, 2021 Sep 27; 7(1). PMID: 34564709 Free PMC article.
Effector T cell responses unleashed by regulatory T cell ablation exacerbate oral squamous cell carcinoma. Jaime L Chao, Michael Korzinkin, +6 authors, Peter A Savage. less Cell Rep Med, 2021 Oct 09; 2(9). PMID: 34622236 Free PMC article.
In vitro 3D liver tumor microenvironment models for immune cell therapy optimization. Maxine Lam, Jose Antonio Reales-Calderon, +2 authors, Jin Rong Ow, Giulia Adriani, Andrea Pavesi. less APL Bioeng, 2021 Oct 12; 5(4). PMID: 34632251 Free PMC article. Review.
Single-Cell RNA-Seq of T Cells in B-ALL Patients Reveals an Exhausted Subset with Remarkable Heterogeneity. Xiaofang Wang, Yanjuan Chen, +8 authors, Yangqiu Li. less Adv Sci (Weinh), 2021 Aug 09; 8(19). PMID: 34365737 Free PMC article.
Construction and Validation of an Immune Cell Signature Score to Evaluate Prognosis and Therapeutic Efficacy in Hepatocellular Carcinoma. Linfeng Xu, Xingxing Jian, +4 authors, Lu Xie. less Front Genet, 2021 Oct 15; 12. PMID: 34646307 Free PMC article.
Drug-Induced Resistance and Phenotypic Switch in Triple-Negative Breast Cancer Can Be Controlled via Resolution and Targeting of Individualized Signaling Signatures. Swetha Vasudevan, Ibukun A Adejumobi, +4 authors, Nataly Kravchenko-Balasha. less Cancers (Basel), 2021 Oct 14; 13(19). PMID: 34638492 Free PMC article.
Single-cell transcriptomic analysis of the tumor ecosystems underlying initiation and progression of papillary thyroid carcinoma. Weilin Pu, Xiao Shi, +18 authors, Yu-Long Wang. less Nat Commun, 2021 Oct 20; 12(1). PMID: 34663816 Free PMC article.
Atlas of clinically distinct cell states and ecosystems across human solid tumors. Bogdan A Luca, Chloé B Steen, +10 authors, Aaron M Newman. less Cell, 2021 Oct 02; 184(21). PMID: 34597583 Free PMC article.
CD161, a promising Immune Checkpoint, correlates with Patient Prognosis: A Pan-cancer Analysis. Wenrui Ye, Cong Luo, +2 authors, Chenglong Li, Zhixiong Liu, Fangkun Liu. less J Cancer, 2021 Oct 19; 12(21). PMID: 34659549 Free PMC article.
Development and Verification of an Immune-Related Gene Pairs Prognostic Signature in Hepatocellular Carcinoma. Xiaofei Feng, Shanshan Mu, Yao Ma, Wenji Wang. Front Mol Biosci, 2021 Oct 19; 8. PMID: 34660693 Free PMC article.
Single-Cell Analysis of the Multicellular Ecosystem in Viral Carcinogenesis by HTLV-1. Junji Koya, Yuki Saito, +20 authors, Keisuke Kataoka. less Blood Cancer Discov, 2021 Oct 19; 2(5). PMID: 34661162 Free PMC article.
Single-cell RNA sequencing reveals spatiotemporal heterogeneity and malignant progression in pancreatic neuroendocrine tumor. Yu Zhou, Siyang Liu, +6 authors, Rufu Chen. less Int J Biol Sci, 2021 Oct 22; 17(14). PMID: 34671197 Free PMC article.
Knowledge-based classification of fine-grained immune cell types in single-cell RNA-Seq data. Xuan Liu, Sara J C Gosline, +5 authors, Jeffrey T Chang. less Brief Bioinform, 2021 Mar 09; 22(5). PMID: 33681983 Free PMC article.
Aortic heterogeneity across segments and under high fat/salt/glucose conditions at the single-cell level. Dongxu He, Aiqin Mao, +5 authors, Xin Ma. less Natl Sci Rev, 2020 May 01; 7(5). PMID: 34692110 Free PMC article.
Crosstalk Between the Tumor Microenvironment and Cancer Cells: A Promising Predictive Biomarker for Immune Checkpoint Inhibitors. Xiaoying Li, Yueyao Yang, +4 authors, Ming Liu. less Front Cell Dev Biol, 2021 Oct 26; 9. PMID: 34692696 Free PMC article. Review.
Single-cell sequencing reveals antitumor characteristics of intratumoral immune cells in old mice. Cangang Zhang, Lei Lei, +14 authors, Baojun Zhang. less J Immunother Cancer, 2021 Oct 14; 9(10). PMID: 34642245 Free PMC article.
Rapid Identification of the Tumor-Specific Reactive TIL Repertoire via Combined Detection of CD137, TNF, and IFNγ, Following Recognition of Autologous Tumor-Antigens. Arianna Draghi, Christopher Aled Chamberlain, +16 authors, Marco Donia. less Front Immunol, 2021 Oct 29; 12. PMID: 34707600 Free PMC article.
Integrating single cell sequencing with a spatial quantitative systems pharmacology model spQSP for personalized prediction of triple-negative breast cancer immunotherapy response. Shuming Zhang, Chang Gong, +5 authors, Elana J Fertig. less Immunoinformatics (Amst), 2021 Oct 29; 1-2. PMID: 34708216 Free PMC article.
Miscell: An efficient self-supervised learning approach for dissecting single-cell transcriptome. Hongru Shen, Yang Li, +13 authors, Xiangchun Li. less iScience, 2021 Oct 30; 24(11). PMID: 34712916 Free PMC article.
Phased differentiation of γδ T and T CD8 tumor-infiltrating lymphocytes revealed by single-cell transcriptomics of human cancers. Juan-Pablo Cerapio, Marion Perrier, +15 authors, Jean-Jacques Fournie. less Oncoimmunology, 2021 Nov 02; 10(1). PMID: 34721945 Free PMC article.
Application of Single-Cell Multi-Omics in Dissecting Cancer Cell Plasticity and Tumor Heterogeneity. Deshen Pan, Deshui Jia. Front Mol Biosci, 2021 Nov 02; 8. PMID: 34722635 Free PMC article. Review.
Exhaustion in tumor-infiltrating Mucosal-Associated Invariant T (MAIT) cells from colon cancer patients. William Rodin, Patrik Sundström, +5 authors, Marianne Quiding Järbrink. less Cancer Immunol Immunother, 2021 Apr 23; 70(12). PMID: 33885944 Free PMC article.
Immunogenomic Landscape Analysis of Prognostic Immune-Related Genes in Hepatocellular Carcinoma. Peng Qin, Mengyu Zhang, Xue Liu, Ziming Dong. J Healthc Eng, 2021 Nov 09; 2021. PMID: 34745496 Free PMC article.
The Single-Cell Sequencing: A Dazzling Light Shining on the Dark Corner of Cancer. Jing Li, Nan Yu, +2 authors, Xin Li, Mengna Cui, Qie Guo. less Front Oncol, 2021 Nov 09; 11. PMID: 34745998 Free PMC article. Review.
The Single-Cell Transcriptomic Analysis of Prefrontal Pyramidal Cells and Interneurons Reveals the Neuronal Expression of Genes Encoding Antimicrobial Peptides and Immune Proteins. Dániel Mittli, Vanda Tukacs, +4 authors, Katalin Adrienna Kékesi. less Front Immunol, 2021 Nov 12; 12. PMID: 34759929 Free PMC article.
Deciphering cell lineage specification of human lung adenocarcinoma with single-cell RNA sequencing. Zhoufeng Wang, Zhe Li, +16 authors, Weimin Li. less Nat Commun, 2021 Nov 13; 12(1). PMID: 34764257 Free PMC article.
Immunotherapies for hepatocellular carcinoma. Josep M Llovet, Florian Castet, +6 authors, Richard S Finn. less Nat Rev Clin Oncol, 2021 Nov 13; 19(3). PMID: 34764464 Review.
Intrinsic and Extrinsic Control of Hepatocellular Carcinoma by TAM Receptors. Viola Hedrich, Kristina Breitenecker, +2 authors, Leila Djerlek, Gregor Ortmayr, Wolfgang Mikulits. less Cancers (Basel), 2021 Nov 14; 13(21). PMID: 34771611 Free PMC article. Review.
Intratumor Heterogeneity in Hepatocellular Carcinoma: Challenges and Opportunities. Sharanya Maanasi Kalasekar, Chad H VanSant-Webb, Kimberley J Evason. Cancers (Basel), 2021 Nov 14; 13(21). PMID: 34771685 Free PMC article. Review.
Dynamic regulatory networks of T cell trajectory dissect transcriptional control of T cell state transition. Min Yan, Jing Hu, +9 authors, Xia Li. less Mol Ther Nucleic Acids, 2021 Nov 18; 26. PMID: 34786214 Free PMC article.
Application of single-cell RNA sequencing technology in liver diseases: a narrative review. Lian He, Anjing Lu, +4 authors, Yuqi He. less Ann Transl Med, 2021 Nov 19; 9(20). PMID: 34790804 Free PMC article. Review.
Single-cell analysis of diverse immune phenotypes in malignant pleural effusion. Zhong-Yin Huang, Ming-Ming Shao, +9 authors, Huan-Zhong Shi. less Nat Commun, 2021 Nov 20; 12(1). PMID: 34795282 Free PMC article.
mTOR-dependent translation drives tumor infiltrating CD8+ effector and CD4+ Treg cells expansion. Benedetta De Ponte Conti, Annarita Miluzio, +3 authors, Sara Ricciardi. less Elife, 2021 Nov 18; 10. PMID: 34787568 Free PMC article.
Spatial transcriptomics reveals gene expression characteristics in invasive micropapillary carcinoma of the breast. Jianke Lv, Qianqian Shi, +11 authors, Li Fu. less Cell Death Dis, 2021 Nov 21; 12(12). PMID: 34799559 Free PMC article.
Single-cell atlas of tumor cell evolution in response to therapy in hepatocellular carcinoma and intrahepatic cholangiocarcinoma. Lichun Ma, Limin Wang, +15 authors, Xin Wei Wang. less J Hepatol, 2021 Jul 04; 75(6). PMID: 34216724 Free PMC article.
Deciphering the Intercellular Communication Network of Peripartum Decidua that Orchestrates Delivery. Jingrui Huang, Weishe Zhang, +7 authors, Lei Dai. less Front Cell Dev Biol, 2021 Nov 23; 9. PMID: 34805176 Free PMC article.
Direct Comparative Analyses of 10X Genomics Chromium and Smart-seq2. Xiliang Wang, Yao He, +2 authors, Qiming Zhang, Xianwen Ren, Zemin Zhang. less Genomics Proteomics Bioinformatics, 2021 Mar 05; 19(2). PMID: 33662621 Free PMC article.
Exposure to Tobacco Smoking Induces a subset of Activated Tumor-resident Tregs in Non-Small Cell Lung Cancer. Yudi Hu, Chaoqun Xu, +6 authors, Qiyuan Li. less Transl Oncol, 2021 Nov 13; 15(1). PMID: 34768099 Free PMC article.
Neoadjuvant PD-1 blockade induces T cell and cDC1 activation but fails to overcome the immunosuppressive tumor associated macrophages in recurrent glioblastoma. Alexander H Lee, Lu Sun, +11 authors, Robert M Prins. less Nat Commun, 2021 Nov 28; 12(1). PMID: 34836966 Free PMC article.
Targeted Anti-Tumor Immunotherapy Using Tumor Infiltrating Cells. Yifan Xie, Feng Xie, +7 authors, Fangfang Zhou. less Adv Sci (Weinh), 2021 Oct 19; 8(22). PMID: 34658167 Free PMC article. Review.
Activated but impaired IFN-γ production of mucosal-associated invariant T cells in patients with hepatocellular carcinoma. Wenyong Huang, Dongmei Ye, +3 authors, Wenjing He, Xiaoshun He, Xiaomin Shi, Yifang Gao. less J Immunother Cancer, 2021 Nov 19; 9(11). PMID: 34789552 Free PMC article.
Amplification of spatially isolated adenosine pathway by tumor-macrophage interaction induces anti-PD1 resistance in hepatocellular carcinoma. Jia-Cheng Lu, Peng-Fei Zhang, +12 authors, Jia Fan. less J Hematol Oncol, 2021 Nov 29; 14(1). PMID: 34838121 Free PMC article.
RNA-Binding Protein Expression Alters Upon Differentiation of Human B Cells and T Cells. Nordin D Zandhuis, Benoit P Nicolet, Monika C Wolkers. Front Immunol, 2021 Dec 07; 12. PMID: 34867946 Free PMC article.
Targeting Immune Cells in the Tumor Microenvironment of HCC: New Opportunities and Challenges. Xiaopei Hao, Guangshun Sun, +5 authors, Xuehao Wang. less Front Cell Dev Biol, 2021 Dec 07; 9. PMID: 34869376 Free PMC article. Review.
Targeting T Cell Subtypes for NAFLD and NAFLD-Related HCC Treatment: An Opinion. Chunye Zhang, Ming Yang. Front Med (Lausanne), 2021 Dec 07; 8. PMID: 34869507 Free PMC article.
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Single-Cell RNA Sequencing Reveals the Heterogeneity of Infiltrating Immune Cell Profiles in the Hepatic Cystic Echinococcosis Microenvironment. Aimaiti Yasen, Wujianan Sun, +13 authors, Hao Wen. less Infect Immun, 2021 Sep 08; 89(12). PMID: 34491790 Free PMC article.
Multiplex imaging reveals the architecture of the tumor immune microenvironment. Junlei Zhang, Jinyuan Song, +2 authors, Jianpeng Sheng, Xueli Bai, Tingbo Liang. less Cancer Biol Med, 2021 Oct 29;. PMID: 34709000 Free PMC article.
Identification of molecular subtypes and prognostic signature for hepatocellular carcinoma based on genes associated with homologous recombination deficiency. Hongsheng Lin, Yangyi Xie, +2 authors, Yinzhi Kong, Li Yang, Mingfen Li. less Sci Rep, 2021 Dec 17; 11(1). PMID: 34912005 Free PMC article.
Expansion of tumor-associated Treg cells upon disruption of a CTLA-4-dependent feedback loop. Francesco Marangoni, Ademi Zhakyp, +10 authors, Thorsten R Mempel. less Cell, 2021 Jun 23; 184(15). PMID: 34157302 Free PMC article.
CREM Is Correlated With Immune-Suppressive Microenvironment and Predicts Poor Prognosis in Gastric Adenocarcinoma. Kuai Yu, Linju Kuang, +6 authors, Aiping Le. less Front Cell Dev Biol, 2021 Dec 24; 9. PMID: 34938728 Free PMC article.
Immunotherapy for Hepatocellular Carcinoma: New Prospects for the Cancer Therapy. Rossella Fasano, Mahdi Abdoli Shadbad, +6 authors, Nicola Silvestris. less Life (Basel), 2021 Dec 25; 11(12). PMID: 34947886 Free PMC article. Review.
Single-Cell Transcriptome Analysis Reveals RGS1 as a New Marker and Promoting Factor for T-Cell Exhaustion in Multiple Cancers. Yunmeng Bai, Meiling Hu, +2 authors, Zixi Chen, Jinfen Wei, Hongli Du. less Front Immunol, 2021 Dec 28; 12. PMID: 34956194 Free PMC article.
Key Candidate Prognostic Biomarkers Correlated with Immune Infiltration in Hepatocellular Carcinoma. Zenghua Deng, Kanghua Huang, +7 authors, Jirun Peng. less J Hepatocell Carcinoma, 2021 Dec 28; 8. PMID: 34956967 Free PMC article.
Comprehensive analysis of spatial architecture in primary liver cancer. Rui Wu, Wenbo Guo, +26 authors, Lei Chen. less Sci Adv, 2021 Dec 18; 7(51). PMID: 34919432 Free PMC article.
Immunosuppression and outcomes in adult patients with de novo acute myeloid leukemia with normal karyotypes. Francesca Ferraro, Christopher A Miller, +24 authors, Timothy J Ley. less Proc Natl Acad Sci U S A, 2021 Dec 01; 118(49). PMID: 34845035 Free PMC article.
CancerSCEM: a database of single-cell expression map across various human cancers. Jingyao Zeng, Yadong Zhang, +9 authors, Jingfa Xiao. less Nucleic Acids Res, 2021 Oct 14; 50(D1). PMID: 34643725 Free PMC article.
Single-cell transcriptomics reveals opposing roles of Shp2 in Myc-driven liver tumor cells and microenvironment. Wendy S Chen, Yan Liang, +5 authors, Gen-Sheng Feng. less Cell Rep, 2021 Nov 11; 37(6). PMID: 34758313 Free PMC article.
Current Perspectives on the Immunosuppressive Niche and Role of Fibrosis in Hepatocellular Carcinoma and the Development of Antitumor Immunity. Tomoko Aoki, Naoshi Nishida, Masatoshi Kudo. J Histochem Cytochem, 2021 Nov 10; 70(1). PMID: 34751050 Free PMC article. Review.
Tumor-Associated Regulatory T Cell Expression of LAIR2 Is Prognostic in Lung Adenocarcinoma. Dalam Ly, Quan Li, +6 authors, Li Zhang. less Cancers (Basel), 2022 Jan 12; 14(1). PMID: 35008369 Free PMC article.
Single-Cell RNA-Seq Technologies and Computational Analysis Tools: Application in Cancer Research. Qianqian Song, Liang Liu. Methods Mol Biol, 2022 Jan 20; 2413. PMID: 35044670 Review.
Tissue-specific Tregs in cancer metastasis: opportunities for precision immunotherapy. Laura A Huppert, Michael D Green, +4 authors, James C Lee. less Cell Mol Immunol, 2021 Aug 22; 19(1). PMID: 34417572 Free PMC article. Review.
Single-Cell RNA Sequencing Reveals the Role of Phosphorylation-Related Genes in Hepatocellular Carcinoma Stem Cells. Fuwen Yao, Yongqiang Zhan, +12 authors, Lisha Mou. less Front Cell Dev Biol, 2022 Jan 22; 9. PMID: 35059393 Free PMC article.
Prognostic Landscape of Tumor-Infiltrating T and B Cells in Human Cancer. Ming Zheng, Yi-Ming Li, +7 authors, Zhi-Nan Chen. less Front Immunol, 2022 Jan 25; 12. PMID: 35069521 Free PMC article.
Multi-Omics Analysis of the Gut-Liver Axis Reveals the Mechanism of Liver Injury in Colitis Mice. Luoyi Zhu, Xin Zong, +6 authors, Yizhen Wang. less Front Immunol, 2022 Jan 25; 12. PMID: 35069545 Free PMC article.
CD26/DPP4 as a Therapeutic Target in Nonalcoholic Steatohepatitis Associated Hepatocellular Carcinoma. Sohji Nishina, Keisuke Hino. Cancers (Basel), 2022 Jan 22; 14(2). PMID: 35053615 Free PMC article. Review.
Dissecting the heterogeneity of the microenvironment in primary and recurrent nasopharyngeal carcinomas using single-cell RNA sequencing. Wen-Sa Peng, Xin Zhou, +9 authors, Chao-Su Hu. less Oncoimmunology, 2022 Feb 01; 11(1). PMID: 35096485 Free PMC article.
The Emerging Role of Tissue-Resident Memory CD8+ T Lymphocytes in Human Digestive Tract Cancers. Xinyu Mei, Huan Li, +2 authors, Xinpeng Zhou, Min Cheng, Kele Cui. less Front Oncol, 2022 Feb 01; 11. PMID: 35096624 Free PMC article. Review.
An atlas of dynamic peripheral blood mononuclear cell landscapes in human perioperative anaesthesia/surgery. Yang-Yang Wang, En-Qiang Chang, +8 authors, Jia-Qiang Zhang. less Clin Transl Med, 2022 Jan 22; 12(1). PMID: 35061932 Free PMC article.
Single-cell immune profiling reveals functional diversity of T cells in tuberculous pleural effusion. Yi Cai, Yejun Wang, +13 authors, Xinchun Chen. less J Exp Med, 2022 Jan 22; 219(3). PMID: 35061012 Free PMC article.
Selective delivery of low-affinity IL-2 to PD-1+ T cells rejuvenates antitumor immunity with reduced toxicity. Zhenhua Ren, Anli Zhang, +5 authors, Yang-Xin Fu. less J Clin Invest, 2022 Feb 02; 132(3). PMID: 35104810 Free PMC article.
Low expression of AQP9 and its value in hepatocellular carcinoma. Cheng Gao, Jianbo Shen, +4 authors, Zhong Chen. less Transl Cancer Res, 2022 Feb 05; 10(4). PMID: 35116505 Free PMC article.
Prudent application of single-cell RNA sequencing in understanding cellular features and functional phenotypes in cancer studies. Xuanhao Xu, Zemin Zhang. Chin J Cancer Res, 2022 Feb 08; 33(6). PMID: 35125815 Free PMC article.
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Evaluating tumor-infiltrating lymphocytes in hepatocellular carcinoma using hematoxylin and eosin-stained tumor sections. Min Du, Yu-Meng Cai, +2 authors, Yu-Lei Yin, Li Xiao, Yuan Ji. less World J Clin Cases, 2022 Feb 08; 10(3). PMID: 35127901 Free PMC article.
CD161 expression and regulation defines rapidly responding effector CD4+ T cells associated with improved survival in HPV16-associated tumors. Chantal L Duurland, Saskia J Santegoets, +14 authors, Sjoerd H van der Burg. less J Immunother Cancer, 2022 Jan 19; 10(1). PMID: 35039463 Free PMC article.
Single-cell transcriptomics reveals a low CD8+ T cell infiltrating state mediated by fibroblasts in recurrent renal cell carcinoma. Yu-Lu Peng, Long-Bin Xiong, +19 authors, Zhi-Ling Zhang. less J Immunother Cancer, 2022 Feb 06; 10(2). PMID: 35121646 Free PMC article.
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Revealing Clonal Responses of Tumor-Reactive T-Cells Through T Cell Receptor Repertoire Analysis. Hiroyasu Aoki, Shigeyuki Shichino, Kouji Matsushima, Satoshi Ueha. Front Immunol, 2022 Feb 15; 13. PMID: 35154125 Free PMC article. Review.
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Ulcerative colitis is characterized by a plasmablast-skewed humoral response associated with disease activity. Mathieu Uzzan, Jerome C Martin, +53 authors, Saurabh Mehandru. less Nat Med, 2022 Feb 23; 28(4). PMID: 35190725 Free PMC article.
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A Novel Prognostic Biomarker LPAR6 in Hepatocellular Carcinoma via Associating with Immune Infiltrates. Jian He, Mei Meng, Hui Wang. J Clin Transl Hepatol, 2022 Mar 03; 10(1). PMID: 35233377 Free PMC article.
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Identification of an IDO1-based immune classifier for survival prediction of upper tract urothelial carcinoma. Wenlong Zhong, Meng Yang, +13 authors, Tianxin Lin. less Cancer Sci, 2021 Dec 29; 113(3). PMID: 34962030 Free PMC article.
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Pregnancy and Tumour: The Parallels and Differences in Regulatory T Cells. Prerana Muralidhara, Vanshika Sood, Vishnu Vinayak Ashok, Kushagra Bansal. Front Immunol, 2022 May 03; 13. PMID: 35493450 Free PMC article. Review.
High-throughput single-сell sequencing in cancer research. Qingzhu Jia, Han Chu, +2 authors, Zheng Jin, Haixia Long, Bo Zhu. less Signal Transduct Target Ther, 2022 May 04; 7(1). PMID: 35504878 Free PMC article. Review.
DIALOGUE maps multicellular programs in tissue from single-cell or spatial transcriptomics data. Livnat Jerby-Arnon, Aviv Regev. Nat Biotechnol, 2022 May 06;. PMID: 35513526
Single-cell characterization of malignant phenotypes and microenvironment alteration in retinoblastoma. Cheng Wu, Jiaqi Yang, +7 authors, Zhi Xie. less Cell Death Dis, 2022 May 07; 13(5). PMID: 35523772 Free PMC article.
Decaprenyl Diphosphate Synthase Subunit 1 (PDSS1): A Potential Prognostic Biomarker and Immunotherapy-Target for Hepatocellular Carcinoma. Yuping Yang, Jinying Li, +2 authors, Ming Tang, Biao Nie, Wei Huang. less Cancer Manag Res, 2022 May 11; 14. PMID: 35535267 Free PMC article.
Tumor heterogeneity reshapes the tumor microenvironment to influence drug resistance. Aiping Zhang, Kai Miao, Heng Sun, Chu-Xia Deng. Int J Biol Sci, 2022 May 12; 18(7). PMID: 35541919 Free PMC article. Review.
Single-cell landscape of immunocytes in patients with extrahepatic cholangiocarcinoma. Lei Xu, Yun Lu, +5 authors, Jianming Wang. less J Transl Med, 2022 May 14; 20(1). PMID: 35562760 Free PMC article.
Dissecting Intra-Tumoral Changes Following Immune Checkpoint Blockades in Intrahepatic Cholangiocarcinoma via Single-Cell Analysis. Bao-Ye Sun, Cheng Zhou, +8 authors, Shuang-Jian Qiu. less Front Immunol, 2022 May 14; 13. PMID: 35558087 Free PMC article.
The Era of Cytotoxic CD4 T Cells. Mara Cenerenti, Margaux Saillard, Pedro Romero, Camilla Jandus. Front Immunol, 2022 May 17; 13. PMID: 35572552 Free PMC article. Review.
Single-Cell Sequencing and Its Applications in Liver Cancer. Binle Tian, Qi Li. Front Oncol, 2022 May 17; 12. PMID: 35574365 Free PMC article. Review.
Emerging immunotherapy for HCC: A guide for hepatologists. Friedrich Foerster, Simon Johannes Gairing, Sumera Irie Ilyas, Peter Robert Galle. Hepatology, 2022 Mar 08; 75(6). PMID: 35253934 Free PMC article. Review.
An activation to memory differentiation trajectory of tumor-infiltrating lymphocytes informs metastatic melanoma outcomes. Abhinav Jaiswal, Akanksha Verma, +17 authors, Niroshana Anandasabapathy. less Cancer Cell, 2022 May 11; 40(5). PMID: 35537413 Free PMC article.
Artificial intelligence for the prevention and clinical management of hepatocellular carcinoma. Julien Calderaro, Tobias Paul Seraphin, Tom Luedde, Tracey G Simon. J Hepatol, 2022 May 20; 76(6). PMID: 35589255 Free PMC article. Review.
Distribution, phenotype, functional and clinical relevance of CD8+CD103+ tissue-resident memory T cells in human gastric cancer. Yang Shen, Xiao-Long Li, +11 authors, Liu-Sheng Peng. less Cancer Immunol Immunother, 2021 Nov 13; 71(7). PMID: 34767045
Identification of a novel prognostic signature for HCC and analysis of costimulatory molecule-related lncRNA AC099850.3. Qi Wang, Qiong Fang, +2 authors, Yanping Huang, Jin Zhou, Meimei Liu. less Sci Rep, 2022 Jun 16; 12(1). PMID: 35705628

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