Journal Article
. 2017 Jun; 169(7):1342-1356.e16.
doi: 10.1016/j.cell.2017.05.035.

Landscape of Infiltrating T Cells in Liver Cancer Revealed by Single-Cell Sequencing

Chunhong Zheng 1 Liangtao Zheng 2 Jae-Kwang Yoo 3 Huahu Guo 4 Yuanyuan Zhang 1 Xinyi Guo 1 Boxi Kang 1 Ruozhen Hu 3 Julie Y Huang 3 Qiming Zhang 1 Zhouzerui Liu 1 Minghui Dong 1 Xueda Hu 1 Wenjun Ouyang 5 Jirun Peng 6 Zemin Zhang 7 
Affiliations
  • PMID: 28622514
  •     602 citations

Abstract

Systematic interrogation of tumor-infiltrating lymphocytes is key to the development of immunotherapies and the prediction of their clinical responses in cancers. Here, we perform deep single-cell RNA sequencing on 5,063 single T cells isolated from peripheral blood, tumor, and adjacent normal tissues from six hepatocellular carcinoma patients. The transcriptional profiles of these individual cells, coupled with assembled T cell receptor (TCR) sequences, enable us to identify 11 T cell subsets based on their molecular and functional properties and delineate their developmental trajectory. Specific subsets such as exhausted CD8+ T cells and Tregs are preferentially enriched and potentially clonally expanded in hepatocellular carcinoma (HCC), and we identified signature genes for each subset. One of the genes, layilin, is upregulated on activated CD8+ T cells and Tregs and represses the CD8+ T cell functions in vitro. This compendium of transcriptome data provides valuable insights and a rich resource for understanding the immune landscape in cancers.

Keywords: RNA-seq; T cell exhaustion; T cell receptor; bioinformatics; biomarkers; cancer immunology; hepatocellular carcinoma; immunotherapy; single-cell sequencing; tumor infiltrating lymphocytes.

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Immunity, 2019 Jan 13; 50(1). PMID: 30635236    Free PMC article.
Highly Cited.
Hedgehog signaling patterns the oral-aboral axis of the mandibular arch.
Jingyue Xu, Han Liu, +4 authors, Rulang Jiang.
Elife, 2019 Jan 15; 8. PMID: 30638444    Free PMC article.
TCR Repertoire Analysis Reveals Mobilization of Novel CD8+ T Cell Clones Into the Cancer-Immunity Cycle Following Anti-CD4 Antibody Administration.
Hiroyasu Aoki, Satoshi Ueha, +5 authors, Kouji Matsushima.
Front Immunol, 2019 Feb 09; 9. PMID: 30733724    Free PMC article.
LAYN Is a Prognostic Biomarker and Correlated With Immune Infiltrates in Gastric and Colon Cancers.
Jing-Hua Pan, Hong Zhou, +6 authors, Lijun Rong.
Front Immunol, 2019 Feb 15; 10. PMID: 30761122    Free PMC article.
Highly Cited.
Casting a wider net: Immunosurveillance by nonclassical MHC molecules.
M Patricia D'Souza, Erin Adams, +22 authors, Jonathan W Yewdell.
PLoS Pathog, 2019 Feb 23; 15(2). PMID: 30789961    Free PMC article.
Review.
Emerging Role of the Pathologist in Precision Medicine for HCC.
Thomas Longerich, Peter Schirmacher.
Dig Dis Sci, 2019 Mar 01; 64(4). PMID: 30815826
Review.
Single-cell RNA sequencing of lung adenocarcinoma reveals heterogeneity of immune response-related genes.
Ke-Yue Ma, Alexandra A Schonnesen, +4 authors, Ning Jiang.
JCI Insight, 2019 Mar 02; 4(4). PMID: 30821712    Free PMC article.
Lineage Tracing in Humans Enabled by Mitochondrial Mutations and Single-Cell Genomics.
Leif S Ludwig, Caleb A Lareau, +17 authors, Vijay G Sankaran.
Cell, 2019 Mar 05; 176(6). PMID: 30827679    Free PMC article.
Highly Cited.
Biomarkers: What Role Do They Play (If Any) for Diagnosis, Prognosis and Tumor Response Prediction for Hepatocellular Carcinoma?
James J Harding, Danny N Khalil, Ghassan K Abou-Alfa.
Dig Dis Sci, 2019 Mar 07; 64(4). PMID: 30838478
Review.
Treg programming and therapeutic reprogramming in cancer.
Mariela A Moreno Ayala, Zehui Li, Michel DuPage.
Immunology, 2019 Mar 14; 157(3). PMID: 30866047    Free PMC article.
Review.
Genomic and transcriptional heterogeneity of multifocal hepatocellular carcinoma.
L X Xu, M H He, +12 authors, M Kuang.
Ann Oncol, 2019 Mar 28; 30(6). PMID: 30916311    Free PMC article.
Single-cell transcriptomic landscape of nucleated cells in umbilical cord blood.
Yi Zhao, Xiao Li, +20 authors, Xiao Liu.
Gigascience, 2019 May 03; 8(5). PMID: 31049560    Free PMC article.
Decomposing Cell Identity for Transfer Learning across Cellular Measurements, Platforms, Tissues, and Species.
Genevieve L Stein-O'Brien, Brian S Clark, +9 authors, Elana J Fertig.
Cell Syst, 2019 May 24; 8(5). PMID: 31121116    Free PMC article.
Highly Cited.
Chronic Liver Disease in Humans Causes Expansion and Differentiation of Liver Lymphatic Endothelial Cells.
Beth A Jiron Tamburini, Jeffrey M Finlon, +7 authors, Matthew A Burchill.
Front Immunol, 2019 Jun 04; 10. PMID: 31156626    Free PMC article.
Tissue-infiltrating lymphocytes signature predicts survival in patients with early/intermediate stage hepatocellular carcinoma.
Meng-Xin Tian, Wei-Ren Liu, +16 authors, Ying-Hong Shi.
BMC Med, 2019 Jun 06; 17(1). PMID: 31164128    Free PMC article.
SSCC: A Novel Computational Framework for Rapid and Accurate Clustering Large-scale Single Cell RNA-seq Data.
Xianwen Ren, Liangtao Zheng, Zemin Zhang.
Genomics Proteomics Bioinformatics, 2019 Jun 16; 17(2). PMID: 31202000    Free PMC article.
Estimation of immune cell content in tumor using single-cell RNA-seq reference data.
Xiaoqing Yu, Y Ann Chen, +2 authors, Xuefeng Wang.
BMC Cancer, 2019 Jul 22; 19(1). PMID: 31324168    Free PMC article.
Deep single-cell RNA sequencing data of individual T cells from treatment-naïve colorectal cancer patients.
Yuanyuan Zhang, Liangtao Zheng, +3 authors, Zemin Zhang.
Sci Data, 2019 Jul 26; 6(1). PMID: 31341169    Free PMC article.
Computational approaches for characterizing the tumor immune microenvironment.
Candace C Liu, Chloé B Steen, Aaron M Newman.
Immunology, 2019 Jul 28; 158(2). PMID: 31347163    Free PMC article.
Review.
A validated single-cell-based strategy to identify diagnostic and therapeutic targets in complex diseases.
Danuta R Gawel, Jordi Serra-Musach, +29 authors, Mikael Benson.
Genome Med, 2019 Jul 31; 11(1). PMID: 31358043    Free PMC article.
Identification of drug-specific public TCR driving severe cutaneous adverse reactions.
Ren-You Pan, Mu-Tzu Chu, +15 authors, Shuen-Iu Hung.
Nat Commun, 2019 Aug 10; 10(1). PMID: 31395875    Free PMC article.
Multimodal single-cell approaches shed light on T cell heterogeneity.
Aparna Nathan, Yuriy Baglaenko, +2 authors, Soumya Raychaudhuri.
Curr Opin Immunol, 2019 Aug 21; 61. PMID: 31430664    Free PMC article.
Review.
Single-cell profiling guided combinatorial immunotherapy for fast-evolving CDK4/6 inhibitor-resistant HER2-positive breast cancer.
Qingfei Wang, Ian H Guldner, +4 authors, Siyuan Zhang.
Nat Commun, 2019 Aug 25; 10(1). PMID: 31444334    Free PMC article.
Aging promotes reorganization of the CD4 T cell landscape toward extreme regulatory and effector phenotypes.
Yehezqel Elyahu, Idan Hekselman, +12 authors, Alon Monsonego.
Sci Adv, 2019 Aug 29; 5(8). PMID: 31457092    Free PMC article.
A next-generation tumor-targeting IL-2 preferentially promotes tumor-infiltrating CD8+ T-cell response and effective tumor control.
Zhichen Sun, Zhenhua Ren, +12 authors, Hua Peng.
Nat Commun, 2019 Aug 30; 10(1). PMID: 31462678    Free PMC article.
Single-Cell Analysis of Crohn's Disease Lesions Identifies a Pathogenic Cellular Module Associated with Resistance to Anti-TNF Therapy.
Jerome C Martin, Christie Chang, +28 authors, Ephraim Kenigsberg.
Cell, 2019 Sep 03; 178(6). PMID: 31474370    Free PMC article.
Highly Cited.
Select sequencing of clonally expanded CD8+ T cells reveals limits to clonal expansion.
Huang Huang, Michael J Sikora, +5 authors, Lars M Steinmetz.
Proc Natl Acad Sci U S A, 2019 Apr 18; 116(18). PMID: 30992377    Free PMC article.
Application of single-cell RNA sequencing methodologies in understanding haematopoiesis and immunology.
Anna M Ranzoni, Paulina M Strzelecka, Ana Cvejic.
Essays Biochem, 2019 Jun 13; 63(2). PMID: 31186287    Free PMC article.
Review.
MAIT Cells Come to the Rescue in Cancer Immunotherapy?
Zuzanna Lukasik, Dirk Elewaut, Koen Venken.
Cancers (Basel), 2020 Feb 15; 12(2). PMID: 32053875    Free PMC article.
Review.
High-dimensional cytometric analysis of colorectal cancer reveals novel mediators of antitumour immunity.
Natasja L de Vries, Vincent van Unen, +9 authors, Noel F C C de Miranda.
Gut, 2019 Jul 05; 69(4). PMID: 31270164    Free PMC article.
LILRB1 Blockade Enhances Bispecific T Cell Engager Antibody-Induced Tumor Cell Killing by Effector CD8+ T Cells.
Aeryon Kim, Chia-Jung Han, +6 authors, Xin Yu.
J Immunol, 2019 Jun 30; 203(4). PMID: 31253728    Free PMC article.
TGF-β inhibition via CRISPR promotes the long-term efficacy of CAR T cells against solid tumors.
Na Tang, Chen Cheng, +6 authors, Haoyi Wang.
JCI Insight, 2020 Jan 31; 5(4). PMID: 31999649    Free PMC article.
CD29 identifies IFN-γ-producing human CD8+ T cells with an increased cytotoxic potential.
Benoît P Nicolet, Aurélie Guislain, +4 authors, Monika C Wolkers.
Proc Natl Acad Sci U S A, 2020 Mar 13; 117(12). PMID: 32161126    Free PMC article.
Tumor-infiltrating immune cells in hepatocellular carcinoma: Tregs is correlated with poor overall survival.
SiZhe Yu, Yu Wang, +9 authors, Hui Guo.
PLoS One, 2020 Apr 03; 15(4). PMID: 32240238    Free PMC article.
Single-Cell Approaches to Profile the Response to Immune Checkpoint Inhibitors.
Lara Gibellini, Sara De Biasi, +5 authors, Andrea Cossarizza.
Front Immunol, 2020 Apr 09; 11. PMID: 32265933    Free PMC article.
Review.
Impaired Anti-Tumor T cell Response in Hepatocellular Carcinoma.
Nada Chaoul, Serena Mancarella, +2 authors, Francesco Dituri.
Cancers (Basel), 2020 Mar 19; 12(3). PMID: 32182707    Free PMC article.
Dimension Reduction and Clustering Models for Single-Cell RNA Sequencing Data: A Comparative Study.
Chao Feng, Shufen Liu, +5 authors, Xiaoyue Feng.
Int J Mol Sci, 2020 Apr 03; 21(6). PMID: 32235704    Free PMC article.
A Single-Cell Perspective of the Mammalian Liver in Health and Disease.
Xuelian Xiong, Henry Kuang, Tongyu Liu, Jiandie D Lin.
Hepatology, 2020 Jan 31; 71(4). PMID: 31997380    Free PMC article.
Review.
ImmuCellAI: A Unique Method for Comprehensive T-Cell Subsets Abundance Prediction and its Application in Cancer Immunotherapy.
Ya-Ru Miao, Qiong Zhang, +4 authors, An-Yuan Guo.
Adv Sci (Weinh), 2020 Apr 11; 7(7). PMID: 32274301    Free PMC article.
HBV-Induced Immune Imbalance in the Development of HCC.
Yongyan Chen, Zhigang Tian.
Front Immunol, 2019 Sep 12; 10. PMID: 31507621    Free PMC article.
Review.
Quantitative Mechanistic Modeling in Support of Pharmacological Therapeutics Development in Immuno-Oncology.
Kirill Peskov, Ivan Azarov, +3 authors, Gabriel Helmlinger.
Front Immunol, 2019 May 28; 10. PMID: 31134058    Free PMC article.
Review.
Tumour grade significantly correlates with total dysfunction of tumour tissue-infiltrating lymphocytes in renal cell carcinoma.
Atsunari Kawashima, Takayuki Kanazawa, +19 authors, Norio Nonomura.
Sci Rep, 2020 Apr 12; 10(1). PMID: 32277125    Free PMC article.
Striking a Balance-Cellular and Molecular Drivers of Memory T Cell Development and Responses to Chronic Stimulation.
Jennifer L Hope, Christopher J Stairiker, +2 authors, Linda M Bradley.
Front Immunol, 2019 Aug 06; 10. PMID: 31379821    Free PMC article.
Review.
Tertiary Lymphoid Organs in Cancer Immunology: Mechanisms and the New Strategy for Immunotherapy.
Liangbin Lin, Xiang Hu, Huiyuan Zhang, Hongbo Hu.
Front Immunol, 2019 Jul 10; 10. PMID: 31281318    Free PMC article.
Review.
Deciphering the transcriptomic landscape of tumor-infiltrating CD8 lymphocytes in B16 melanoma tumors with single-cell RNA-Seq.
Santiago J Carmona, Imran Siddiqui, +2 authors, David Gfeller.
Oncoimmunology, 2020 Apr 22; 9(1). PMID: 32313720    Free PMC article.
Single‑cell RNA sequencing of t(8;21) acute myeloid leukemia for risk prediction.
Qian Xiong, Sai Huang, +12 authors, Li Yu.
Oncol Rep, 2020 Apr 24; 43(4). PMID: 32323795    Free PMC article.
Changing Technologies of RNA Sequencing and Their Applications in Clinical Oncology.
Ye Wang, Michael Mashock, +7 authors, Xinmin Li.
Front Oncol, 2020 Apr 25; 10. PMID: 32328458    Free PMC article.
Review.
GEPIA2: an enhanced web server for large-scale expression profiling and interactive analysis.
Zefang Tang, Boxi Kang, +2 authors, Zemin Zhang.
Nucleic Acids Res, 2019 May 23; 47(W1). PMID: 31114875    Free PMC article.
Highly Cited.
Ushering in Integrated T Cell Repertoire Profiling in Cancer.
Ning Jiang, Alexandra A Schonnesen, Ke-Yue Ma.
Trends Cancer, 2019 Feb 14; 5(2). PMID: 30755308    Free PMC article.
Review.
TOX transcriptionally and epigenetically programs CD8+ T cell exhaustion.
Omar Khan, Josephine R Giles, +22 authors, E John Wherry.
Nature, 2019 Jun 18; 571(7764). PMID: 31207603    Free PMC article.
Highly Cited.
Eomes identifies thymic precursors of self-specific memory-phenotype CD8+ T cells.
Christine H Miller, David E J Klawon, +3 authors, Peter A Savage.
Nat Immunol, 2020 Apr 15; 21(5). PMID: 32284593    Free PMC article.
Immune-based therapies for hepatocellular carcinoma.
David J Pinato, Nadia Guerra, +8 authors, Lorenza Rimassa.
Oncogene, 2020 Mar 12; 39(18). PMID: 32157213    Free PMC article.
Review.
CD4+ teff cell heterogeneity: the perspective from single-cell transcriptomics.
David Zemmour, Evgeny Kiner, Christophe Benoist.
Curr Opin Immunol, 2020 Apr 08; 63. PMID: 32259715    Free PMC article.
Review.
Single-cell RNA sequencing reveals the heterogeneity of liver-resident immune cells in human.
Juanjuan Zhao, Shuye Zhang, +10 authors, Zheng Zhang.
Cell Discov, 2020 May 01; 6. PMID: 32351704    Free PMC article.
Identification of TP53 mutation associated-immunotype and prediction of survival in patients with hepatocellular carcinoma.
Muqi Shi, Yan Wang, +6 authors, Haijian Zhang.
Ann Transl Med, 2020 May 02; 8(6). PMID: 32355765    Free PMC article.
Immune Landscape of Viral- and Carcinogen-Driven Head and Neck Cancer.
Anthony R Cillo, Cornelius H L Kürten, +13 authors, Dario A A Vignali.
Immunity, 2020 Jan 12; 52(1). PMID: 31924475    Free PMC article.
NCOA5 deficiency promotes a unique liver protumorigenic microenvironment through p21WAF1/CIP1 overexpression, which is reversed by metformin.
Mark Williams, Xinhui Liu, +9 authors, Hua Xiao.
Oncogene, 2020 Mar 24; 39(19). PMID: 32203160    Free PMC article.
The liver as an immunological barrier redefined by single-cell analysis.
Zania Stamataki, Leo Swadling.
Immunology, 2020 Mar 17; 160(2). PMID: 32176810    Free PMC article.
Review.
Identification and validation of an immunogenic subtype of gastric cancer with abundant intratumoural CD103+CD8+ T cells conferring favourable prognosis.
Ruochen Li, Hao Liu, +16 authors, Jiejie Xu.
Br J Cancer, 2020 Mar 25; 122(10). PMID: 32205862    Free PMC article.
The Spatial and Genomic Hierarchy of Tumor Ecosystems Revealed by Single-Cell Technologies.
Eric A Smith, H Courtney Hodges.
Trends Cancer, 2019 Jul 18; 5(7). PMID: 31311656    Free PMC article.
Review.
Comprehensive evaluation of transcriptome-based cell-type quantification methods for immuno-oncology.
Gregor Sturm, Francesca Finotello, +5 authors, Tatsiana Aneichyk.
Bioinformatics, 2019 Sep 13; 35(14). PMID: 31510660    Free PMC article.
Highly Cited.
Heterogeneity of exhausted T cells in the tumor microenvironment is linked to patient survival following resection in hepatocellular carcinoma.
Fangming Liu, Weiren Liu, +9 authors, Duojiao Wu.
Oncoimmunology, 2020 May 20; 9(1). PMID: 32426177    Free PMC article.
Recirculation and Residency of T Cells and Tregs: Lessons Learnt in Anacapri.
Silvia Piconese, Silvia Campello, Ambra Natalini.
Front Immunol, 2020 May 21; 11. PMID: 32431695    Free PMC article.
Review.
Dysfunctional CD8 T Cells Form a Proliferative, Dynamically Regulated Compartment within Human Melanoma.
Hanjie Li, Anne M van der Leun, +15 authors, Ido Amit.
Cell, 2019 Jan 01; 176(4). PMID: 30595452    Free PMC article.
Highly Cited.
The Mechanism of Anti-PD-L1 Antibody Efficacy against PD-L1-Negative Tumors Identifies NK Cells Expressing PD-L1 as a Cytolytic Effector.
Wenjuan Dong, Xiaojin Wu, +8 authors, Jianhua Yu.
Cancer Discov, 2019 Jul 26; 9(10). PMID: 31340937    Free PMC article.
Highly Cited.
The Tumor Microenvironment in the Response to Immune Checkpoint Blockade Therapies.
Florent Petitprez, Maxime Meylan, +2 authors, Wolf H Fridman.
Front Immunol, 2020 May 28; 11. PMID: 32457745    Free PMC article.
Review.
IRF4 instructs effector Treg differentiation and immune suppression in human cancer.
Giorgia Alvisi, Jolanda Brummelman, +18 authors, Enrico Lugli.
J Clin Invest, 2020 Mar 04; 130(6). PMID: 32125291    Free PMC article.
Single-Cell Genomic Characterization Reveals the Cellular Reprogramming of the Gastric Tumor Microenvironment.
Anuja Sathe, Susan M Grimes, +5 authors, Hanlee P Ji.
Clin Cancer Res, 2020 Feb 16; 26(11). PMID: 32060101    Free PMC article.
Molecular subtypes of oropharyngeal cancer show distinct immune microenvironment related with immune checkpoint blockade response.
Min Hwan Kim, Jae-Hwan Kim, +15 authors, Hye Ryun Kim.
Br J Cancer, 2020 Apr 03; 122(11). PMID: 32235905    Free PMC article.
Accounting for cell type hierarchy in evaluating single cell RNA-seq clustering.
Zhijin Wu, Hao Wu.
Genome Biol, 2020 May 27; 21(1). PMID: 32450895    Free PMC article.
A conserved intratumoral regulatory T cell signature identifies 4-1BB as a pan-cancer target.
Zachary T Freeman, Thomas R Nirschl, +17 authors, Charles G Drake.
J Clin Invest, 2020 Feb 06; 130(3). PMID: 32015231    Free PMC article.
ZBED2 is an antagonist of interferon regulatory factor 1 and modifies cell identity in pancreatic cancer.
Tim D D Somerville, Yali Xu, +6 authors, Christopher R Vakoc.
Proc Natl Acad Sci U S A, 2020 May 10; 117(21). PMID: 32385160    Free PMC article.
Downexpression of HSD17B6 correlates with clinical prognosis and tumor immune infiltrates in hepatocellular carcinoma.
Lei Lv, Yujia Zhao, +2 authors, Qiyi Yi.
Cancer Cell Int, 2020 Jun 10; 20. PMID: 32514254    Free PMC article.
Prostate cancer research: The next generation; report from the 2019 Coffey-Holden Prostate Cancer Academy Meeting.
Andrea K Miyahira, Adam Sharp, +8 authors, Howard R Soule.
Prostate, 2019 Dec 12; 80(2). PMID: 31825540    Free PMC article.
Review.
Immune Phenotype and Immune Checkpoint Inhibitors for the Treatment of Human Hepatocellular Carcinoma.
Naoshi Nishida, Masatoshi Kudo.
Cancers (Basel), 2020 May 24; 12(5). PMID: 32443599    Free PMC article.
Review.
Decreased cytotoxic T cells and TCR clonality in organ transplant recipients with squamous cell carcinoma.
Nicholas Frazzette, Alireza Khodadadi-Jamayran, +5 authors, John A Carucci.
NPJ Precis Oncol, 2020 Jun 19; 4. PMID: 32550269    Free PMC article.
Single-cell transcriptome and antigen-immunoglobin analysis reveals the diversity of B cells in non-small cell lung cancer.
Jian Chen, Yun Tan, +16 authors, Peng Zhang.
Genome Biol, 2020 Jun 26; 21(1). PMID: 32580738    Free PMC article.
Unravelling the heterogeneity and dynamic relationships of tumor-infiltrating T cells by single-cell RNA sequencing analysis.
Xin Yu, Lei Zhang, +2 authors, Wenjun Ouyang.
J Leukoc Biol, 2020 Apr 10; 107(6). PMID: 32272497    Free PMC article.
Review.
Intratumoral CD4+ T Cells Mediate Anti-tumor Cytotoxicity in Human Bladder Cancer.
David Y Oh, Serena S Kwek, +17 authors, Lawrence Fong.
Cell, 2020 Jun 05; 181(7). PMID: 32497499    Free PMC article.
Applications of single-cell sequencing for the field of otolaryngology: A contemporary review.
Madeline P Pyle, Michael Hoa.
Laryngoscope Investig Otolaryngol, 2020 Jul 01; 5(3). PMID: 32596483    Free PMC article.
Review.
Immune profiling of pediatric solid tumors.
Rachael L Terry, Deborah Meyran, +4 authors, Paul J Neeson.
J Clin Invest, 2020 Jun 17; 130(7). PMID: 32538896    Free PMC article.
Review.
Early precursors and molecular determinants of tissue-resident memory CD8+ T lymphocytes revealed by single-cell RNA sequencing.
Nadia S Kurd, Zhaoren He, +15 authors, John T Chang.
Sci Immunol, 2020 May 18; 5(47). PMID: 32414833    Free PMC article.
ULBP1 Is Elevated in Human Hepatocellular Carcinoma and Predicts Outcome.
Nicholas J W Easom, Michael Marks, +4 authors, Ramou Njie.
Front Oncol, 2020 Jul 14; 10. PMID: 32656081    Free PMC article.
Identification of non-cancer cells from cancer transcriptomic data.
Michele Bortolomeazzi, Mohamed Reda Keddar, Francesca D Ciccarelli, Lorena Benedetti.
Biochim Biophys Acta Gene Regul Mech, 2019 Oct 28; 1863(6). PMID: 31654804    Free PMC article.
Review.
Cancer systems immunology.
Nathan E Reticker-Flynn, Edgar G Engleman.
Elife, 2020 Jul 14; 9. PMID: 32657757    Free PMC article.
Review.
Trajectory and Functional Analysis of PD-1high CD4+CD8+ T Cells in Hepatocellular Carcinoma by Single-Cell Cytometry and Transcriptome Sequencing.
Bo Zheng, Dongfang Wang, +15 authors, Lei Chen.
Adv Sci (Weinh), 2020 Jul 17; 7(13). PMID: 32670760    Free PMC article.
Toward Systems Biomarkers of Response to Immune Checkpoint Blockers.
Óscar Lapuente-Santana, Federica Eduati.
Front Oncol, 2020 Jul 17; 10. PMID: 32670886    Free PMC article.
Review.
Severely ill COVID-19 patients display augmented functional properties in SARS-CoV-2-reactive CD8 + T cells.
Anthony Kusnadi, Ciro Ramírez-Suástegui, +8 authors, Christian H Ottensmeier.
bioRxiv, 2020 Jul 18;. PMID: 32676602    Free PMC article.
Dissecting the Tumor-Immune Landscape in Chimeric Antigen Receptor T-cell Therapy: Key Challenges and Opportunities for a Systems Immunology Approach.
Gregory M Chen, Andrew Azzam, +3 authors, Kai Tan.
Clin Cancer Res, 2020 Mar 05; 26(14). PMID: 32127393    Free PMC article.
Review.
Knockdown of THOC1 reduces the proliferation of hepatocellular carcinoma and increases the sensitivity to cisplatin.
Shijiao Cai, Yunpeng Bai, +12 authors, Tao Sun.
J Exp Clin Cancer Res, 2020 Jul 17; 39(1). PMID: 32669125    Free PMC article.
Pan-Cancer Analysis of Immune Cell Infiltration Identifies a Prognostic Immune-Cell Characteristic Score (ICCS) in Lung Adenocarcinoma.
Shuguang Zuo, Min Wei, +2 authors, Jiwu Wei.
Front Immunol, 2020 Jul 28; 11. PMID: 32714316    Free PMC article.
Cancer and HIV-1 Infection: Patterns of Chronic Antigen Exposure.
Selena Vigano, Sara Bobisse, +2 authors, Alexandre Harari.
Front Immunol, 2020 Jul 28; 11. PMID: 32714330    Free PMC article.
Review.
Harnessing big 'omics' data and AI for drug discovery in hepatocellular carcinoma.
Bin Chen, Lana Garmire, +3 authors, Xin Chen.
Nat Rev Gastroenterol Hepatol, 2020 Jan 05; 17(4). PMID: 31900465    Free PMC article.
Review.
Multimodal Analysis of Composition and Spatial Architecture in Human Squamous Cell Carcinoma.
Andrew L Ji, Adam J Rubin, +18 authors, Paul A Khavari.
Cell, 2020 Jun 25; 182(2). PMID: 32579974    Free PMC article.
Intratumoral heterogeneity of hepatocellular carcinoma: From single-cell to population-based studies.
Qi Zhang, Yu Lou, Xue-Li Bai, Ting-Bo Liang.
World J Gastroenterol, 2020 Aug 11; 26(26). PMID: 32774053    Free PMC article.
Review.
Analysis of single-cell RNAseq identifies transitional states of T cells associated with hepatocellular carcinoma.
Yanying Yang, Fangming Liu, +8 authors, Duojiao Wu.
Clin Transl Med, 2020 Jul 14; 10(3). PMID: 32659053    Free PMC article.
High-dimensional single-cell analysis delineates radiofrequency ablation induced immune microenvironmental remodeling in pancreatic cancer.
Qinglin Fei, Yu Pan, +9 authors, Heguang Huang.
Cell Death Dis, 2020 Jul 29; 11(7). PMID: 32719347    Free PMC article.
The history and advances in cancer immunotherapy: understanding the characteristics of tumor-infiltrating immune cells and their therapeutic implications.
Yuanyuan Zhang, Zemin Zhang.
Cell Mol Immunol, 2020 Jul 03; 17(8). PMID: 32612154    Free PMC article.
Review.
Exploiting the Complexities of Glioblastoma Stem Cells: Insights for Cancer Initiation and Therapeutic Targeting.
Joana Vieira de Castro, Céline S Gonçalves, Adília Hormigo, Bruno M Costa.
Int J Mol Sci, 2020 Jul 30; 21(15). PMID: 32722427    Free PMC article.
Review.
Understanding and quantifying the immune microenvironment in hepatocellular carcinoma.
Juan C Osorio, James J Harding.
Transl Gastroenterol Hepatol, 2019 Feb 01; 3. PMID: 30701214    Free PMC article.
CD8+ T cell states in human cancer: insights from single-cell analysis.
Anne M van der Leun, Daniela S Thommen, Ton N Schumacher.
Nat Rev Cancer, 2020 Feb 07; 20(4). PMID: 32024970    Free PMC article.
Review.
Leveraging Public Single-Cell and Bulk Transcriptomic Datasets to Delineate MAIT Cell Roles and Phenotypic Characteristics in Human Malignancies.
Tony Yao, Parisa Shooshtari, S M Mansour Haeryfar.
Front Immunol, 2020 Aug 28; 11. PMID: 32849590    Free PMC article.
Single-Cell Transcriptome Analysis Reveals Six Subpopulations Reflecting Distinct Cellular Fates in Senescent Mouse Embryonic Fibroblasts.
Wei Chen, Xuefei Wang, +10 authors, Ting Ni.
Front Genet, 2020 Aug 28; 11. PMID: 32849838    Free PMC article.
An Immunogram for an Individualized Assessment of the Antitumor Immune Response in Patients With Hepatocellular Carcinoma.
Ying Hu, Huaibo Sun, Henghui Zhang, Xianbo Wang.
Front Oncol, 2020 Aug 28; 10. PMID: 32850343    Free PMC article.
Myeloid signature reveals immune contexture and predicts the prognosis of hepatocellular carcinoma.
Chong Wu, Jie Lin, +17 authors, Limin Zheng.
J Clin Invest, 2020 Jun 05; 130(9). PMID: 32497024    Free PMC article.
Tumor-infiltrating CD62L+PD-1-CD8 T cells retain proliferative potential via Bcl6 expression and replenish effector T cells within the tumor.
Yu Gong, Toshihiro Suzuki, +2 authors, Naoko Nakano.
PLoS One, 2020 Aug 28; 15(8). PMID: 32845913    Free PMC article.
Biological and Medical Importance of Cellular Heterogeneity Deciphered by Single-Cell RNA Sequencing.
Rishikesh Kumar Gupta, Jacek Kuznicki.
Cells, 2020 Jul 28; 9(8). PMID: 32707839    Free PMC article.
Review.
Traditional Chinese medicine as supportive care for the management of liver cancer: Past, present, and future.
Xia Liao, Yang Bu, Qingan Jia.
Genes Dis, 2020 Sep 05; 7(3). PMID: 32884991    Free PMC article.
Review.
Use of Single-Cell -Omic Technologies to Study the Gastrointestinal Tract and Diseases, From Single Cell Identities to Patient Features.
Mirazul Islam, Bob Chen, +2 authors, Ken S Lau.
Gastroenterology, 2020 May 18; 159(2). PMID: 32417404    Free PMC article.
Review.
Endogenous retroviral proteins provide an immunodominant but not requisite antigen in a murine immunotherapy tumor model.
Xuan Ye, Janelle C Waite, +12 authors, Dimitris Skokos.
Oncoimmunology, 2020 Sep 15; 9(1). PMID: 32923116    Free PMC article.
Layilin augments integrin activation to promote antitumor immunity.
Kelly M Mahuron, Joshua M Moreau, +18 authors, Michael D Rosenblum.
J Exp Med, 2020 Jun 17; 217(9). PMID: 32539073    Free PMC article.
Cancer and Microenvironment Plasticity: Double-Edged Swords in Metastasis.
Xueqian Zhuang, Hao Zhang, Guohong Hu.
Trends Pharmacol Sci, 2019 May 13; 40(6). PMID: 31078320    Free PMC article.
Review.
Single-Cell Ssequencing in Cancer: Recent Applications to Immunogenomics and Multi-omics Tools.
Michael C Sierant, Jungmin Choi.
Genomics Inform, 2019 Jan 03; 16(4). PMID: 30602078    Free PMC article.
Genomic and transcriptional Profiling of tumor infiltrated CD8+ T cells revealed functional heterogeneity of antitumor immunity in hepatocellular carcinoma.
Zhenli Li, Geng Chen, +6 authors, Jingfeng Liu.
Oncoimmunology, 2019 Feb 05; 8(2). PMID: 30713796    Free PMC article.
The Impact of Heterogeneity on Single-Cell Sequencing.
Samantha L Goldman, Matthew MacKay, +3 authors, Christopher E Mason.
Front Genet, 2019 Mar 19; 10. PMID: 30881372    Free PMC article.
Landscape of infiltrating B cells and their clinical significance in human hepatocellular carcinoma.
Zhao Zhang, Lijie Ma, +11 authors, Xiaoming Zhang.
Oncoimmunology, 2019 Mar 25; 8(4). PMID: 30906667    Free PMC article.
Single-cell technologies for profiling T cells to enable monitoring of immunotherapies.
Xingyue An, Navin Varadarajan.
Curr Opin Chem Eng, 2018 Mar 01; 19. PMID: 31131208    Free PMC article.
Extensive exploration of T cell heterogeneity in cancers by single cell sequencing.
Xiaofang Wang, Yangqiu Li.
Chin J Cancer Res, 2019 Jun 04; 31(2). PMID: 31156311    Free PMC article.
Big Data Approaches for Modeling Response and Resistance to Cancer Drugs.
Peng Jiang, William R Sellers, X Shirley Liu.
Annu Rev Biomed Data Sci, 2019 Jul 26; 1. PMID: 31342013    Free PMC article.
The single-cell sequencing: new developments and medical applications.
Xiaoning Tang, Yongmei Huang, +2 authors, Xiao Zhu.
Cell Biosci, 2019 Aug 09; 9. PMID: 31391919    Free PMC article.
Review.
Transcriptomic characterization and innovative molecular classification of clear cell renal cell carcinoma in the Chinese population.
Qiang Zhao, Jia Xue, +10 authors, Ning Zhang.
Cancer Cell Int, 2020 Sep 29; 20. PMID: 32982583    Free PMC article.
Studying immune to non-immune cell cross-talk using single-cell technologies.
R Elmentaite, S A Teichmann, E Madissoon.
Curr Opin Syst Biol, 2020 Sep 29; 18. PMID: 32984660    Free PMC article.
Review.
Human Tregs at the materno-fetal interface show site-specific adaptation reminiscent of tumor Tregs.
Judith Wienke, Laura Brouwers, +5 authors, Femke van Wijk.
JCI Insight, 2020 Aug 19; 5(18). PMID: 32809975    Free PMC article.
Biased MAIT TCR Usage Poised for Limited Antigen Diversity?
Michael N T Souter, Sidonia B G Eckle.
Front Immunol, 2020 Oct 06; 11. PMID: 33013835    Free PMC article.
Review.
Correlation Patterns Among B7 Family Ligands and Tryptophan Degrading Enzymes in Hepatocellular Carcinoma.
Raghavan Chinnadurai, Rafaela Scandolara, +5 authors, Greg Gibson.
Front Oncol, 2020 Oct 06; 10. PMID: 33014820    Free PMC article.
Impact of data preprocessing on cell-type clustering based on single-cell RNA-seq data.
Chunxiang Wang, Xin Gao, Juntao Liu.
BMC Bioinformatics, 2020 Oct 09; 21(1). PMID: 33028196    Free PMC article.
Screening Cancer Immunotherapy: When Engineering Approaches Meet Artificial Intelligence.
Xingwu Zhou, Moyuan Qu, +9 authors, Ali Khademhosseini.
Adv Sci (Weinh), 2020 Oct 13; 7(19). PMID: 33042756    Free PMC article.
Review.
Evaluating Distribution and Prognostic Value of New Tumor-Infiltrating Lymphocytes in HCC Based on a scRNA-Seq Study With CIBERSORTx.
Lixing Li, Lu Shen, +8 authors, Tonghai Xing.
Front Med (Lausanne), 2020 Oct 13; 7. PMID: 33043022    Free PMC article.
Analysis of the molecular nature associated with microsatellite status in colon cancer identifies clinical implications for immunotherapy.
Xuanwen Bao, Hangyu Zhang, +10 authors, Fanglong Liu.
J Immunother Cancer, 2020 Oct 09; 8(2). PMID: 33028695    Free PMC article.
Single-cell genomics and spatial transcriptomics: Discovery of novel cell states and cellular interactions in liver physiology and disease biology.
Antonio Saviano, Neil C Henderson, Thomas F Baumert.
J Hepatol, 2020 Jun 14; 73(5). PMID: 32534107    Free PMC article.
Review.
Seven immune-related genes prognostic power and correlation with tumor-infiltrating immune cells in hepatocellular carcinoma.
Tiantian Liu, Hao Wu, +2 authors, Qiang Zhu.
Cancer Med, 2020 Aug 21; 9(20). PMID: 32815653    Free PMC article.
Translational Considerations to Improve Response and Overcome Therapy Resistance in Immunotherapy for Hepatocellular Carcinoma.
Sophia Heinrich, Darko Castven, Peter R Galle, Jens U Marquardt.
Cancers (Basel), 2020 Sep 10; 12(9). PMID: 32899197    Free PMC article.
Review.
Dendritic Cell and T Cell Crosstalk in Liver Fibrogenesis and Hepatocarcinogenesis: Implications for Prevention and Therapy of Liver Cancer.
Isabella Lurje, Linda Hammerich, Frank Tacke.
Int J Mol Sci, 2020 Oct 11; 21(19). PMID: 33036244    Free PMC article.
Review.
Single-cell analysis to understand the diversity of immune cell types that drive disease pathogenesis.
Grégory Seumois, Pandurangan Vijayanand.
J Allergy Clin Immunol, 2019 Nov 11; 144(5). PMID: 31703762    Free PMC article.
Review.
TIGIT Can Exert Immunosuppressive Effects on CD8+ T Cells by the CD155/TIGIT Signaling Pathway for Hepatocellular Carcinoma In Vitro.
Changkun Zhang, Yang Wang, +7 authors, Jiye Zhu.
J Immunother, 2020 Aug 18; 43(8). PMID: 32804915    Free PMC article.
Combinational Immunotherapy for Hepatocellular Carcinoma: Radiotherapy, Immune Checkpoint Blockade and Beyond.
Yun Hua Lee, David Tai, +2 authors, Valerie Chew.
Front Immunol, 2020 Oct 30; 11. PMID: 33117354    Free PMC article.
Review.
Helpless Priming Sends CD8+ T Cells on the Road to Exhaustion.
Julia Busselaar, Sun Tian, Hans van Eenennaam, Jannie Borst.
Front Immunol, 2020 Oct 31; 11. PMID: 33123174    Free PMC article.
Single-Cell RNA-Sequencing Shift in the Interaction Pattern Between Glioma Stem Cells and Immune Cells During Tumorigenesis.
You Zhai, Guanzhang Li, +5 authors, Wei Zhang.
Front Immunol, 2020 Nov 03; 11. PMID: 33133100    Free PMC article.
Functional and Clinical Characterization of Tumor-Infiltrating T Cell Subpopulations in Hepatocellular Carcinoma.
Jianguo Li, Jin Zhou, +3 authors, Jiying Jiang.
Front Genet, 2020 Nov 03; 11. PMID: 33133170    Free PMC article.
Immunotherapy of hepatocellular carcinoma with infection of hepatitis B or C virus.
Cecilia Monge Bonilla, Nicole A McGrath, Jianyang Fu, Changqing Xie.
Hepatoma Res, 2020 Nov 03; 6. PMID: 33134550    Free PMC article.
Heterogeneity and fate choice: T cell exhaustion in cancer and chronic infections.
Mary Philip, Andrea Schietinger.
Curr Opin Immunol, 2019 Jun 11; 58. PMID: 31181510    Free PMC article.
Highly Cited. Review.
Prediction of single-cell gene expression for transcription factor analysis.
Fatemeh Behjati Ardakani, Kathrin Kattler, +8 authors, Marcel H Schulz.
Gigascience, 2020 Oct 31; 9(11). PMID: 33124660    Free PMC article.
The identification and functional analysis of CD8+PD-1+CD161+ T cells in hepatocellular carcinoma.
Zhixuan Li, Bo Zheng, +11 authors, Lei Chen.
NPJ Precis Oncol, 2020 Nov 05; 4. PMID: 33145436    Free PMC article.
Single-cell profiling of the developing mouse brain and spinal cord with split-pool barcoding.
Alexander B Rosenberg, Charles M Roco, +11 authors, Georg Seelig.
Science, 2018 Mar 17; 360(6385). PMID: 29545511    Free PMC article.
Highly Cited.
Reconstruction of cell spatial organization from single-cell RNA sequencing data based on ligand-receptor mediated self-assembly.
Xianwen Ren, Guojie Zhong, +3 authors, Zemin Zhang.
Cell Res, 2020 Jun 17; 30(9). PMID: 32541867    Free PMC article.
A pan-cancer blueprint of the heterogeneous tumor microenvironment revealed by single-cell profiling.
Junbin Qian, Siel Olbrecht, +21 authors, Diether Lambrechts.
Cell Res, 2020 Jun 21; 30(9). PMID: 32561858    Free PMC article.
Tumor-infiltrating TNFRSF9+ CD8+ T cells define different subsets of clear cell renal cell carcinoma with prognosis and immunotherapeutic response.
Yaohui Li, Zewei Wang, +15 authors, Jiejie Xu.
Oncoimmunology, 2020 Nov 13; 9(1). PMID: 33178496    Free PMC article.
Single-Cell Analysis of Different Stages of Oral Cancer Carcinogenesis in a Mouse Model.
Ling-Yu Huang, Yi-Ping Hsieh, +6 authors, Tze-Ta Huang.
Int J Mol Sci, 2020 Nov 05; 21(21). PMID: 33142921    Free PMC article.
Single-Cell Techniques and Deep Learning in Predicting Drug Response.
Zhenyu Wu, Patrick J Lawrence, +3 authors, Qin Ma.
Trends Pharmacol Sci, 2020 Nov 07; 41(12). PMID: 33153777    Free PMC article.
Review.
Single-Cell RNA-Seq Analysis Reveals Microenvironmental Infiltration of Plasma Cells and Hepatocytic Prognostic Markers in HCC With Cirrhosis.
Siwen Zhang, Zhenhao Liu, +2 authors, Lu Xie.
Front Oncol, 2020 Nov 24; 10. PMID: 33224891    Free PMC article.
Qualitative Analysis of Tumor-Infiltrating Lymphocytes across Human Tumor Types Reveals a Higher Proportion of Bystander CD8+ T Cells in Non-Melanoma Cancers Compared to Melanoma.
Aishwarya Gokuldass, Arianna Draghi, +17 authors, Marco Donia.
Cancers (Basel), 2020 Nov 18; 12(11). PMID: 33198174    Free PMC article.
Systems Immunology: Learning the Rules of the Immune System.
Alexandra-Chloé Villani, Siranush Sarkizova, Nir Hacohen.
Annu Rev Immunol, 2018 Apr 21; 36. PMID: 29677477    Free PMC article.
Review.
Cancer research in the era of immunogenomics.
Yochai Wolf, Yardena Samuels.
ESMO Open, 2019 Jan 10; 3(7). PMID: 30622743    Free PMC article.
Review.
Immune contexture defined by single cell technology for prognosis prediction and immunotherapy guidance in cancer.
Tong Wu, Xuan Wu, Hong-Yang Wang, Lei Chen.
Cancer Commun (Lond), 2019 Apr 20; 39(1). PMID: 30999966    Free PMC article.
Review.
Proteomics promises a new era of precision cancer medicine.
Chong Wu, Limin Zheng.
Signal Transduct Target Ther, 2019 May 10; 4. PMID: 31069119    Free PMC article.
Single-Cell RNA-Sequencing Identifies Activation of TP53 and STAT1 Pathways in Human T Lymphocyte Subpopulations in Response to Ex Vivo Radiation Exposure.
Maria Moreno-Villanueva, Ye Zhang, +10 authors, Honglu Wu.
Int J Mol Sci, 2019 May 15; 20(9). PMID: 31083348    Free PMC article.
Inefficient induction of circulating TAA-specific CD8+ T-cell responses in hepatocellular carcinoma.
Catrin Tauber, Michael Schultheiss, +9 authors, Robert Thimme.
Oncotarget, 2019 Sep 10; 10(50). PMID: 31497249    Free PMC article.
Using single-cell technologies to map the human immune system - implications for nephrology.
Benjamin J Stewart, John R Ferdinand, Menna R Clatworthy.
Nat Rev Nephrol, 2019 Dec 14; 16(2). PMID: 31831877
Review.
Regorafenib combined with PD1 blockade increases CD8 T-cell infiltration by inducing CXCL10 expression in hepatocellular carcinoma.
Kohei Shigeta, Aya Matsui, +23 authors, Dan G Duda.
J Immunother Cancer, 2020 Nov 26; 8(2). PMID: 33234602    Free PMC article.
Off-the-Shelf Allogeneic T Cell Therapies for Cancer: Opportunities and Challenges Using Naturally Occurring "Universal" Donor T Cells.
Cynthia Perez, Isabelle Gruber, Caroline Arber.
Front Immunol, 2020 Dec 03; 11. PMID: 33262761    Free PMC article.
Review.
DSAVE: Detection of misclassified cells in single-cell RNA-Seq data.
Johan Gustafsson, Jonathan Robinson, +3 authors, Jens Nielsen.
PLoS One, 2020 Dec 04; 15(12). PMID: 33270740    Free PMC article.
RNA sequencing: new technologies and applications in cancer research.
Mingye Hong, Shuang Tao, +6 authors, Hua Zhang.
J Hematol Oncol, 2020 Dec 06; 13(1). PMID: 33276803    Free PMC article.
Review.
Immune suppressive landscape in the human esophageal squamous cell carcinoma microenvironment.
Yingxia Zheng, Zheyi Chen, +16 authors, Lisong Shen.
Nat Commun, 2020 Dec 10; 11(1). PMID: 33293583    Free PMC article.
Exhausted T cells and epigenetic status.
Ziqing Zeng, Feng Wei, Xiubao Ren.
Cancer Biol Med, 2020 Dec 11; 17(4). PMID: 33299644    Free PMC article.
Review.
Global immune characterization of HBV/HCV-related hepatocellular carcinoma identifies macrophage and T-cell subsets associated with disease progression.
Guohe Song, Yang Shi, +20 authors, Qiang Gao.
Cell Discov, 2020 Dec 11; 6(1). PMID: 33298893    Free PMC article.
Single-cell landscape of immunological responses in patients with COVID-19.
Ji-Yuan Zhang, Xiang-Ming Wang, +18 authors, Fu-Sheng Wang.
Nat Immunol, 2020 Aug 14; 21(9). PMID: 32788748
A dynamic CD2-rich compartment at the outer edge of the immunological synapse boosts and integrates signals.
Philippos Demetriou, Enas Abu-Shah, +20 authors, Michael L Dustin.
Nat Immunol, 2020 Sep 16; 21(10). PMID: 32929275    Free PMC article.
Discovery and Validation of a Metastasis-Related Prognostic and Diagnostic Biomarker for Melanoma Based on Single Cell and Gene Expression Datasets.
Qi Wan, Chengxiu Liu, +3 authors, Zhichong Wang.
Front Oncol, 2020 Dec 17; 10. PMID: 33324561    Free PMC article.
Applications of Single-Cell Omics to Dissect Tumor Microenvironment.
Tingting Guo, Weimin Li, Xuyu Cai.
Front Genet, 2020 Dec 18; 11. PMID: 33329692    Free PMC article.
Review.
A single cell atlas of the human liver tumor microenvironment.
Hassan Massalha, Keren Bahar Halpern, +9 authors, Shalev Itzkovitz.
Mol Syst Biol, 2020 Dec 18; 16(12). PMID: 33332768    Free PMC article.
Tumour evolution in hepatocellular carcinoma.
Amanda J Craig, Johann von Felden, +2 authors, Augusto Villanueva.
Nat Rev Gastroenterol Hepatol, 2019 Dec 04; 17(3). PMID: 31792430
Review.
Association of inflammatory biomarkers with clinical outcomes in nivolumab-treated patients with advanced hepatocellular carcinoma.
Bruno Sangro, Ignacio Melero, +12 authors, Anthony El-Khoueiry.
J Hepatol, 2020 Jul 28; 73(6). PMID: 32710922    Free PMC article.
T Cell Dysfunction in Cancer.
Daniela S Thommen, Ton N Schumacher.
Cancer Cell, 2018 Apr 11; 33(4). PMID: 29634943    Free PMC article.
Highly Cited. Review.
Regulatory T cell control of systemic immunity and immunotherapy response in liver metastasis.
James C Lee, Sadaf Mehdizadeh, +5 authors, Jeffrey A Bluestone.
Sci Immunol, 2020 Oct 04; 5(52). PMID: 33008914    Free PMC article.
Statistical and Bioinformatics Analysis of Data from Bulk and Single-Cell RNA Sequencing Experiments.
Xiaoqing Yu, Farnoosh Abbas-Aghababazadeh, Y Ann Chen, Brooke L Fridley.
Methods Mol Biol, 2020 Sep 15; 2194. PMID: 32926366    Free PMC article.
Review.
Comprehensive Integration of Single-Cell Transcriptional Profiling Reveals the Heterogeneities of Non-cardiomyocytes in Healthy and Ischemic Hearts.
Lingfang Zhuang, Lin Lu, +2 authors, Xiaoxiang Yan.
Front Cardiovasc Med, 2020 Dec 29; 7. PMID: 33365332    Free PMC article.
Identification of Driver Genes Regulating the T-Cell-Infiltrating Levels in Hepatocellular Carcinoma.
Yi Cai, Ying Tian, +8 authors, Zhengxia Yang.
Front Genet, 2021 Jan 01; 11. PMID: 33381145    Free PMC article.
Immunobiology and immunotherapy of HCC: spotlight on innate and innate-like immune cells.
Benjamin Ruf, Bernd Heinrich, Tim F Greten.
Cell Mol Immunol, 2020 Nov 26; 18(1). PMID: 33235387    Free PMC article.
Review.
Specific MiRNAs in naïve T cells associated with Hepatitis C Virus-induced Hepatocellular Carcinoma.
Peng Yan, Pengfei Pang, +7 authors, Junjie Mao.
J Cancer, 2021 Jan 05; 12(1). PMID: 33391397    Free PMC article.
Organized immune cell interactions within tumors sustain a productive T-cell response.
Maria A Cardenas, Nataliya Prokhnevska, Haydn T Kissick.
Int Immunol, 2020 Aug 23; 33(1). PMID: 32827212    Free PMC article.
Review.
Hepatocellular carcinoma: old friends and new tricks.
Eunsun Kim, Patrick Viatour.
Exp Mol Med, 2020 Dec 04; 52(12). PMID: 33268834    Free PMC article.
Review.
TISCH: a comprehensive web resource enabling interactive single-cell transcriptome visualization of tumor microenvironment.
Dongqing Sun, Jin Wang, +13 authors, Chenfei Wang.
Nucleic Acids Res, 2020 Nov 13; 49(D1). PMID: 33179754    Free PMC article.
Tissue-Resident Lymphocytes: Implications in Immunotherapy for Hepatocellular Carcinoma.
Ji Won Han, Seung Kew Yoon.
Int J Mol Sci, 2021 Jan 01; 22(1). PMID: 33379384    Free PMC article.
Review.
Integrative single-cell transcriptome analysis reveals a subpopulation of fibroblasts associated with favorable prognosis of liver cancer patients.
Haiyang Wang, Chao Feng, +9 authors, Xuetao Pei.
Transl Oncol, 2021 Jan 06; 14(1). PMID: 33395744    Free PMC article.
A novel immune classification reveals distinct immune escape mechanism and genomic alterations: implications for immunotherapy in hepatocellular carcinoma.
Zaoqu Liu, Yuyuan Zhang, +5 authors, Xinwei Han.
J Transl Med, 2021 Jan 08; 19(1). PMID: 33407585    Free PMC article.
Single-cell RNA Sequencing in Immunology.
Yirui Cao, Yue Qiu, Guowei Tu, Cheng Yang.
Curr Genomics, 2021 Jan 09; 21(8). PMID: 33414678    Free PMC article.
Review.
T lymphocytes in hepatocellular carcinoma immune microenvironment: insights into human immunology and immunotherapy.
Jin Bian, Jianzhen Lin, +5 authors, Haitao Zhao.
Am J Cancer Res, 2021 Jan 09; 10(12). PMID: 33415021    Free PMC article.
Review.
Mapping the functional landscape of T cell receptor repertoires by single-T cell transcriptomics.
Ze Zhang, Danyi Xiong, +2 authors, Tao Wang.
Nat Methods, 2021 Jan 08; 18(1). PMID: 33408405    Free PMC article.
Single-cell analysis reveals transcriptomic remodellings in distinct cell types that contribute to human prostate cancer progression.
Sujun Chen, Guanghui Zhu, +30 authors, Shancheng Ren.
Nat Cell Biol, 2021 Jan 10; 23(1). PMID: 33420488
Optimal combination treatment regimens of vaccine and radiotherapy augment tumor-bearing host immunity.
Fayun Zhang, Zifeng Zheng, +8 authors, Wei Liang.
Commun Biol, 2021 Jan 21; 4(1). PMID: 33469123    Free PMC article.
Differences in TCR repertoire and T cell activation underlie the divergent outcomes of antitumor immune responses in tumor-eradicating versus tumor-progressing hosts.
Rachel A Woolaver, Xiaoguang Wang, +9 authors, Jing Hong Wang.
J Immunother Cancer, 2021 Jan 09; 9(1). PMID: 33414263    Free PMC article.
Hepatocellular carcinoma.
Josep M Llovet, Robin Kate Kelley, +7 authors, Richard S Finn.
Nat Rev Dis Primers, 2021 Jan 23; 7(1). PMID: 33479224
Review.
Down-regulation of EOMES drives T-cell exhaustion via abolishing EOMES-mediated repression of inhibitory receptors of T cells in liver cancer.
Hongwei He, Yong Yi, +4 authors, Shuangjian Qiu.
J Cell Mol Med, 2020 Dec 17; 25(1). PMID: 33325636    Free PMC article.
Systematic comparison of high-throughput single-cell RNA-seq methods for immune cell profiling.
Tracy M Yamawaki, Daniel R Lu, +8 authors, Chi-Ming Li.
BMC Genomics, 2021 Jan 22; 22(1). PMID: 33472597    Free PMC article.
CXCL13 shapes immunoactive tumor microenvironment and enhances the efficacy of PD-1 checkpoint blockade in high-grade serous ovarian cancer.
Moran Yang, Jiaqi Lu, +5 authors, Haiou Liu.
J Immunother Cancer, 2021 Jan 17; 9(1). PMID: 33452206    Free PMC article.
Single-cell analysis reveals the intra-tumor heterogeneity and identifies MLXIPL as a biomarker in the cellular trajectory of hepatocellular carcinoma.
Xiao Dong, Fan Wang, +7 authors, Qi Li.
Cell Death Discov, 2021 Jan 20; 7(1). PMID: 33462196    Free PMC article.
Current concept for tertiary lymphoid structures in urothelial carcinoma of the bladder: a literature review and our experience.
Milena Gulinac, Dorian Dikov, Simeon Lichev, Tsvetelina Velikova.
Am J Clin Exp Immunol, 2021 Jan 26; 9(5). PMID: 33489474    Free PMC article.
Review.
Opposing immune and genetic mechanisms shape oncogenic programs in synovial sarcoma.
Livnat Jerby-Arnon, Cyril Neftel, +47 authors, Aviv Regev.
Nat Med, 2021 Jan 27; 27(2). PMID: 33495604    Free PMC article.
Mapping the immune environment in clear cell renal carcinoma by single-cell genomics.
Nicholas Borcherding, Ajaykumar Vishwakarma, +7 authors, Weizhou Zhang.
Commun Biol, 2021 Jan 29; 4(1). PMID: 33504936    Free PMC article.
Understanding and Targeting Human Cancer Regulatory T Cells to Improve Therapy.
H Ryan Kolb, Nicholas Borcherding, Weizhou Zhang.
Adv Exp Med Biol, 2021 Feb 02; 1278. PMID: 33523451
PD-1 blockade-unresponsive human tumor-infiltrating CD8+ T cells are marked by loss of CD28 expression and rescued by IL-15.
Kyung Hwan Kim, Hong Kwan Kim, +12 authors, Eui-Cheol Shin.
Cell Mol Immunol, 2020 Apr 26; 18(2). PMID: 32332901    Free PMC article.
Chemotherapeutic and targeted agents can modulate the tumor microenvironment and increase the efficacy of immune checkpoint blockades.
Jun-Yan Li, Yu-Pei Chen, +2 authors, Jun Ma.
Mol Cancer, 2021 Feb 06; 20(1). PMID: 33541368    Free PMC article.
Review.
Improving the Efficacy of Liver Cancer Immunotherapy: The Power of Combined Preclinical and Clinical Studies.
Gen-Sheng Feng, Kaisa L Hanley, Yan Liang, Xiaoxue Lin.
Hepatology, 2020 Jul 28; 73 Suppl 1. PMID: 32715491    Free PMC article.
Review.
Development of a prognostic model based on an immunogenomic landscape analysis of medulloblastoma.
Yuduo Guo, Shenglun Li, +2 authors, Chunjiang Yu.
Biosci Rep, 2020 Dec 22; 41(1). PMID: 33345275    Free PMC article.
Mouse models illuminate MAIT cell biology.
Huimeng Wang, Zhenjun Chen, James McCluskey, Alexandra J Corbett.
Mol Immunol, 2020 Dec 29; 130. PMID: 33360377    Free PMC article.
Review.
A Novel mRNA-miRNA Regulatory Sub-Network Associated With Prognosis of Metastatic Clear Cell Renal Cell Carcinoma.
Tianyu Yang, Xiaofen Miao, +6 authors, Yongsheng Zhang.
Front Oncol, 2021 Feb 06; 10. PMID: 33542901    Free PMC article.
CD137+ T-Cells: Protagonists of the Immunotherapy Revolution.
Alessio Ugolini, Marianna Nuti.
Cancers (Basel), 2021 Feb 04; 13(3). PMID: 33530328    Free PMC article.
Review.
Next Generation Imaging Techniques to Define Immune Topographies in Solid Tumors.
Violena Pietrobon, Alessandra Cesano, Francesco Marincola, Jakob Nikolas Kather.
Front Immunol, 2021 Feb 16; 11. PMID: 33584676    Free PMC article.
Review.
Single-Cell Analysis Reveals Characterization of Infiltrating T Cells in Moderately Differentiated Colorectal Cancer.
Xi Yang, Quan Qi, +6 authors, Shuwen Han.
Front Immunol, 2021 Feb 16; 11. PMID: 33584715    Free PMC article.
Development of a Metastasis-Related Immune Prognostic Model of Metastatic Colorectal Cancer and Its Usefulness to Immunotherapy.
Zhiwen Luo, Xiao Chen, +8 authors, Xinyu Bi.
Front Cell Dev Biol, 2021 Feb 16; 8. PMID: 33585439    Free PMC article.
Dissecting transcriptional heterogeneity in primary gastric adenocarcinoma by single cell RNA sequencing.
Min Zhang, Shuofeng Hu, +7 authors, Yan Liu.
Gut, 2020 Jun 14; 70(3). PMID: 32532891    Free PMC article.
Single-Cell RNA Sequencing Reveals the Expansion of Cytotoxic CD4+ T Lymphocytes and a Landscape of Immune Cells in Primary Sjögren's Syndrome.
Xiaoping Hong, Shuhui Meng, +7 authors, Min Yang.
Front Immunol, 2021 Feb 20; 11. PMID: 33603736    Free PMC article.
Dynamics of thymus function and T cell receptor repertoire breadth in health and disease.
David Granadier, Lorenzo Iovino, Sinéad Kinsella, Jarrod A Dudakov.
Semin Immunopathol, 2021 Feb 21; 43(1). PMID: 33608819    Free PMC article.
Review.
Advancing Cancer Research and Medicine with Single-Cell Genomics.
Bora Lim, Yiyun Lin, Nicholas Navin.
Cancer Cell, 2020 Apr 15; 37(4). PMID: 32289270    Free PMC article.
Review.
Potential therapeutic targets in the tumor microenvironment of hepatocellular carcinoma: reversing the protumor effect of tumor-associated macrophages.
Jingyi Zhou, Weiyu Wang, Qi Li.
J Exp Clin Cancer Res, 2021 Feb 19; 40(1). PMID: 33596985    Free PMC article.
Review.
Progress and Clinical Application of Single-Cell Transcriptional Sequencing Technology in Cancer Research.
Jian Liu, Tianmin Xu, +2 authors, Yan Zhang.
Front Oncol, 2021 Feb 23; 10. PMID: 33614479    Free PMC article.
Review.
IL-2 regulates tumor-reactive CD8+ T cell exhaustion by activating the aryl hydrocarbon receptor.
Yuying Liu, Nannan Zhou, +24 authors, Bo Huang.
Nat Immunol, 2021 Jan 13; 22(3). PMID: 33432230
Pathophysiological Roles of Mucosal-Associated Invariant T Cells in the Context of Gut Microbiota-Liver Axis.
Yoseph Asmelash Gebru, Mi Ran Choi, +7 authors, Ki Tae Suk.
Microorganisms, 2021 Feb 05; 9(2). PMID: 33535703    Free PMC article.
Review.
Therapeutic depletion of CCR8+ tumor-infiltrating regulatory T cells elicits antitumor immunity and synergizes with anti-PD-1 therapy.
Helena Van Damme, Bruno Dombrecht, +26 authors, Jo Agnes Van Ginderachter.
J Immunother Cancer, 2021 Feb 17; 9(2). PMID: 33589525    Free PMC article.
Blinatumomab-induced T cell activation at single cell transcriptome resolution.
Yi Huo, Zhen Sheng, +6 authors, Ruibao Ren.
BMC Genomics, 2021 Mar 03; 22(1). PMID: 33648458    Free PMC article.
Single-cell qPCR Assay with Massively Parallel Microfluidic System.
Marta Prieto-Vila, Takahiro Ochiya, Yusuke Yamamoto.
Bio Protoc, 2021 Mar 05; 10(6). PMID: 33659534    Free PMC article.
Tumor methionine metabolism drives T-cell exhaustion in hepatocellular carcinoma.
Man Hsin Hung, Joo Sang Lee, +11 authors, Xin Wei Wang.
Nat Commun, 2021 Mar 07; 12(1). PMID: 33674593    Free PMC article.
Inhibitory CD161 receptor identified in glioma-infiltrating T cells by single-cell analysis.
Nathan D Mathewson, Orr Ashenberg, +37 authors, Kai W Wucherpfennig.
Cell, 2021 Feb 17; 184(5). PMID: 33592174    Free PMC article.
Circulating clonally expanded T cells reflect functions of tumor-infiltrating T cells.
Liliana E Lucca, Pierre-Paul Axisa, +10 authors, David A Hafler.
J Exp Med, 2021 Mar 03; 218(4). PMID: 33651881    Free PMC article.
Single-cell differential splicing analysis reveals high heterogeneity of liver tumor-infiltrating T cells.
Shang Liu, Biaofeng Zhou, +3 authors, Shiping Liu.
Sci Rep, 2021 Mar 07; 11(1). PMID: 33674641    Free PMC article.
Advances in Human Immune System Mouse Models for Personalized Treg-Based Immunotherapies.
Isabelle Serr, Maria Kral, Martin G Scherm, Carolin Daniel.
Front Immunol, 2021 Mar 09; 12. PMID: 33679808    Free PMC article.
Review.
An Unconventional View of T Cell Reconstitution After Allogeneic Hematopoietic Cell Transplantation.
Hana Andrlová, Marcel R M van den Brink, Kate A Markey.
Front Oncol, 2021 Mar 09; 10. PMID: 33680931    Free PMC article.
Review.
Proteolysis-targeting chimera against BCL-XL destroys tumor-infiltrating regulatory T cells.
Ryan Kolb, Umasankar De, +16 authors, Weizhou Zhang.
Nat Commun, 2021 Feb 26; 12(1). PMID: 33627663    Free PMC article.
Tumor-specific cytolytic CD4 T cells mediate immunity against human cancer.
Amélie Cachot, Mariia Bilous, +22 authors, Camilla Jandus.
Sci Adv, 2021 Feb 28; 7(9). PMID: 33637530    Free PMC article.
Circulating mucosal-associated invariant T cells identify patients responding to anti-PD-1 therapy.
Sara De Biasi, Lara Gibellini, +16 authors, Andrea Cossarizza.
Nat Commun, 2021 Mar 17; 12(1). PMID: 33723257    Free PMC article.
Clinicopathological analysis of neoplastic PD-L1-positive EBV+ diffuse large B cell lymphoma, not otherwise specified, in a Japanese cohort.
Taishi Takahara, Akira Satou, +8 authors, Shigeo Nakamura.
Virchows Arch, 2020 Aug 18; 478(3). PMID: 32803453
Leveraging Single-Cell Approaches in Cancer Precision Medicine.
Aritro Nath, Andrea H Bild.
Trends Cancer, 2021 Feb 11; 7(4). PMID: 33563578    Free PMC article.
Review.
Dynamics in protein translation sustaining T cell preparedness.
Tobias Wolf, Wenjie Jin, +16 authors, Roger Geiger.
Nat Immunol, 2020 Jul 08; 21(8). PMID: 32632289    Free PMC article.
Global DNA hypermethylation pattern and unique gene expression signature in liver cancer from patients with Indigenous American ancestry.
Juan Pablo Cerapio, Agnès Marchio, +8 authors, Pascal Pineau.
Oncotarget, 2021 Mar 23; 12(5). PMID: 33747361    Free PMC article.
Mixed Distribution Models Based on Single-Cell RNA Sequencing Data.
Min Wu, Junhua Xu, Tao Ding, Jie Gao.
Interdiscip Sci, 2021 Mar 24; 13(3). PMID: 33754241
Single-Cell Sequencing, an Advanced Technology in Lung Cancer Research.
Hao Wang, Die Meng, +14 authors, Yayi He.
Onco Targets Ther, 2021 Mar 25; 14. PMID: 33758510    Free PMC article.
Review.
Identification of tumor mutation burden-related hub genes and the underlying mechanism in melanoma.
Chuan Zhang, Dan Dang, +2 authors, Xianling Cong.
J Cancer, 2021 Mar 25; 12(8). PMID: 33758620    Free PMC article.
Leveraging Single-Cell RNA-seq Data to Uncover the Association Between Cell Type and Chronic Liver Diseases.
Xiangyu Ye, Julong Wei, +7 authors, Rongbin Yu.
Front Genet, 2021 Mar 26; 12. PMID: 33763117    Free PMC article.
The architectural design of CD8+ T cell responses in acute and chronic infection: Parallel structures with divergent fates.
H Kay Chung, Bryan McDonald, Susan M Kaech.
J Exp Med, 2021 Mar 24; 218(4). PMID: 33755719    Free PMC article.
Review.
SLC1A4: A Powerful Prognostic Marker and Promising Therapeutic Target for HCC.
Xiaozhen Peng, Ruochan Chen, +2 authors, Yiya Zhang.
Front Oncol, 2021 Mar 30; 11. PMID: 33777811    Free PMC article.
A new antisarcoma strategy: multisubtype heat shock protein/peptide immunotherapy combined with PD-L1 immunological checkpoint inhibitors.
H Li, X Sui, +6 authors, Q Guo.
Clin Transl Oncol, 2021 Apr 02; 23(8). PMID: 33792840    Free PMC article.
A dual immune signature of CD8+ T cells and MMP9 improves the survival of patients with hepatocellular carcinoma.
Huan Ding, Huan Hu, Feifei Tian, Huaping Liang.
Biosci Rep, 2021 Mar 04; 41(3). PMID: 33656546    Free PMC article.
Hepatocellular Carcinoma Immune Landscape and the Potential of Immunotherapies.
Julie Giraud, Domitille Chalopin, Jean-Frédéric Blanc, Maya Saleh.
Front Immunol, 2021 Apr 06; 12. PMID: 33815418    Free PMC article.
Review.
Phenotyping of immune and endometrial epithelial cells in endometrial carcinomas revealed by single-cell RNA sequencing.
Yu-E Guo, Yiran Li, +6 authors, Qin Yan.
Aging (Albany NY), 2021 Jan 12; 13(5). PMID: 33429363    Free PMC article.
CD8+ T Cell Responses during HCV Infection and HCC.
Maike Hofmann, Catrin Tauber, Nina Hensel, Robert Thimme.
J Clin Med, 2021 Apr 04; 10(5). PMID: 33801203    Free PMC article.
Review.
Novel approaches to liver disease diagnosis and modeling.
André G Oliveira, Romina Fiorotto.
Transl Gastroenterol Hepatol, 2021 Apr 08; 6. PMID: 33824923    Free PMC article.
Review.
Decoding Cancer Biology One Cell at a Time.
L Nicolas Gonzalez Castro, Itay Tirosh, Mario L Suvà.
Cancer Discov, 2021 Apr 04; 11(4). PMID: 33811126    Free PMC article.
Review.
MAIT Cells: Partners or Enemies in Cancer Immunotherapy?
Dasha T Cogswell, Laurent Gapin, +2 authors, Richard P Tobin.
Cancers (Basel), 2021 Apr 04; 13(7). PMID: 33805904    Free PMC article.
Review.
Atlas of breast cancer infiltrated B-lymphocytes revealed by paired single-cell RNA-sequencing and antigen receptor profiling.
Qingtao Hu, Yu Hong, +10 authors, Yu Zhang.
Nat Commun, 2021 Apr 14; 12(1). PMID: 33846305    Free PMC article.
Single-cell technologies in hepatology: new insights into liver biology and disease pathogenesis.
Prakash Ramachandran, Kylie P Matchett, +2 authors, Neil C Henderson.
Nat Rev Gastroenterol Hepatol, 2020 Jun 03; 17(8). PMID: 32483353
Review.
Predicting recognition between T cell receptors and epitopes with TCRGP.
Emmi Jokinen, Jani Huuhtanen, +2 authors, Harri Lähdesmäki.
PLoS Comput Biol, 2021 Mar 26; 17(3). PMID: 33764977    Free PMC article.
A novel panel based on immune infiltration and tumor mutational burden for prognostic prediction in hepatocellular carcinoma.
Chan Xie, Hewei Wu, +6 authors, Liang Peng.
Aging (Albany NY), 2021 Mar 14; 13(6). PMID: 33714200    Free PMC article.
High-dimensional analysis of the adenosine pathway in high-grade serous ovarian cancer.
Yacine Bareche, Sandra Pommey, +11 authors, John Stagg.
J Immunother Cancer, 2021 Mar 28; 9(3). PMID: 33771891    Free PMC article.
Single-cell RNA-seq reveals dynamic change in tumor microenvironment during pancreatic ductal adenocarcinoma malignant progression.
Kai Chen, Qi Wang, +5 authors, Yinmo Yang.
EBioMedicine, 2021 Apr 06; 66. PMID: 33819739    Free PMC article.
Lineage-dependent gene expression programs influence the immune landscape of colorectal cancer.
Hae-Ock Lee, Yourae Hong, +34 authors, Woong-Yang Park.
Nat Genet, 2020 May 27; 52(6). PMID: 32451460

;. PMID: 33907176
Single-cell sequencing techniques from individual to multiomics analyses.
Yukie Kashima, Yoshitaka Sakamoto, +3 authors, Ayako Suzuki.
Exp Mol Med, 2020 Sep 16; 52(9). PMID: 32929221    Free PMC article.
Review.
Single-cell transcriptomics in cancer: computational challenges and opportunities.
Jean Fan, Kamil Slowikowski, Fan Zhang.
Exp Mol Med, 2020 Sep 16; 52(9). PMID: 32929226    Free PMC article.
Review.
Activated Regulatory T-Cells, Dysfunctional and Senescent T-Cells Hinder the Immunity in Pancreatic Cancer.
Shivan Sivakumar, Enas Abu-Shah, +13 authors, Michael L Dustin.
Cancers (Basel), 2021 May 01; 13(8). PMID: 33917832    Free PMC article.
RNA Flow Cytometry for the Study of T Cell Metabolism.
Alessandra Rossi, Ilenia Pacella, Silvia Piconese.
Int J Mol Sci, 2021 May 01; 22(8). PMID: 33918901    Free PMC article.
Review.
Immune Checkpoints in Pediatric Solid Tumors: Targetable Pathways for Advanced Therapeutic Purposes.
Claudia Cocco, Fabio Morandi, Irma Airoldi.
Cells, 2021 May 01; 10(4). PMID: 33920505    Free PMC article.
Review.
Anti-PD-1/PD-L1 Based Combination Immunotherapy to Boost Antigen-Specific CD8+ T Cell Response in Hepatocellular Carcinoma.
Julia Peña-Asensio, Henar Calvo, +3 authors, Juan-Ramón Larrubia.
Cancers (Basel), 2021 May 01; 13(8). PMID: 33923463    Free PMC article.
Review.
Recruitment and Expansion of Tregs Cells in the Tumor Environment-How to Target Them?
Justine Cinier, Margaux Hubert, +5 authors, Christine Ménétrier-Caux.
Cancers (Basel), 2021 May 01; 13(8). PMID: 33924428    Free PMC article.
Review.
Monitoring T Cells Responses Mounted by Therapeutic Cancer Vaccines.
Kue Peng Lim, Nur Syafinaz Zainal.
Front Mol Biosci, 2021 May 04; 8. PMID: 33937323    Free PMC article.
Review.
Severely ill COVID-19 patients display impaired exhaustion features in SARS-CoV-2-reactive CD8+ T cells.
Anthony Kusnadi, Ciro Ramírez-Suástegui, +8 authors, Christian H Ottensmeier.
Sci Immunol, 2021 Jan 23; 6(55). PMID: 33478949    Free PMC article.
STARTRAC analyses of scRNAseq data from tumor models reveal T cell dynamics and therapeutic targets.
Dev Bhatt, Boxi Kang, +13 authors, Wenjun Ouyang.
J Exp Med, 2021 Apr 27; 218(6). PMID: 33900375    Free PMC article.
Single-Cell TCR Sequencing Reveals the Dynamics of T Cell Repertoire Profiling During Pneumocystis Infection.
Hu-Qin Yang, Yi-Shan Wang, Kan Zhai, Zhao-Hui Tong.
Front Microbiol, 2021 May 08; 12. PMID: 33959105    Free PMC article.
Conserved human effector Treg cell transcriptomic and epigenetic signature in arthritic joint inflammation.
Gerdien Mijnheer, Lisanne Lutter, +16 authors, Femke van Wijk.
Nat Commun, 2021 May 13; 12(1). PMID: 33976194    Free PMC article.
TRIM68, PIKFYVE, and DYNLL2: The Possible Novel Autophagy- and Immunity-Associated Gene Biomarkers for Osteosarcoma Prognosis.
Jie Jiang, Dachang Liu, +18 authors, Xinli Zhan.
Front Oncol, 2021 May 11; 11. PMID: 33968741    Free PMC article.
What are the applications of single-cell RNA sequencing in cancer research: a systematic review.
Lvyuan Li, Fang Xiong, +15 authors, Can Guo.
J Exp Clin Cancer Res, 2021 May 13; 40(1). PMID: 33975628    Free PMC article.
Systematic Review.
Targeting human Acyl-CoA:cholesterol acyltransferase as a dual viral and T cell metabolic checkpoint.
Nathalie M Schmidt, Peter A C Wing, +18 authors, Mala K Maini.
Nat Commun, 2021 May 16; 12(1). PMID: 33990561    Free PMC article.
Bystander CD8+ T cells are abundant and phenotypically distinct in human tumour infiltrates.
Yannick Simoni, Etienne Becht, +29 authors, Evan W Newell.
Nature, 2018 May 18; 557(7706). PMID: 29769722
Highly Cited.
Poor clinical outcomes and immunoevasive contexture in CXCL13+CD8+ T cells enriched gastric cancer patients.
Kaifeng Jin, Yifan Cao, +13 authors, Jiejie Xu.
Oncoimmunology, 2021 May 18; 10(1). PMID: 33996266    Free PMC article.
Longitudinal single-cell profiling reveals molecular heterogeneity and tumor-immune evolution in refractory mantle cell lymphoma.
Shaojun Zhang, Vivian Changying Jiang, +34 authors, Michael Wang.
Nat Commun, 2021 May 19; 12(1). PMID: 34001881    Free PMC article.
Deciphering Tumor Heterogeneity in Hepatocellular Carcinoma (HCC)-Multi-Omic and Singulomic Approaches.
Renumathy Dhanasekaran.
Semin Liver Dis, 2021 Mar 26; 41(1). PMID: 33764481    Free PMC article.
Review.
Clonally expanded EOMES+ Tr1-like cells in primary and metastatic tumors are associated with disease progression.
Raoul J P Bonnal, Grazisa Rossetti, +43 authors, Massimiliano Pagani.
Nat Immunol, 2021 May 22; 22(6). PMID: 34017124
Progressive immune dysfunction with advancing disease stage in renal cell carcinoma.
David A Braun, Kelly Street, +32 authors, Catherine J Wu.
Cancer Cell, 2021 Mar 13; 39(5). PMID: 33711273    Free PMC article.
Pseudocell Tracer-A method for inferring dynamic trajectories using scRNAseq and its application to B cells undergoing immunoglobulin class switch recombination.
Derek Reiman, Godhev Kumar Manakkat Vijay, +5 authors, Aly A Khan.
PLoS Comput Biol, 2021 May 04; 17(5). PMID: 33939691    Free PMC article.
Single-cell RNA sequencing in cancer: Applications, advances, and emerging challenges.
Guangshun Sun, Zhouxiao Li, +9 authors, Yangbai Sun.
Mol Ther Oncolytics, 2021 May 25; 21. PMID: 34027052    Free PMC article.
Review.
CDSeqR: fast complete deconvolution for gene expression data from bulk tissues.
Kai Kang, Caizhi Huang, +2 authors, Leping Li.
BMC Bioinformatics, 2021 May 26; 22(1). PMID: 34030626    Free PMC article.
The Crosstalk Between Cancer Cells and Neutrophils Enhances Hepatocellular Carcinoma Metastasis via Neutrophil Extracellular Traps-Associated Cathepsin G Component: A Potential Therapeutic Target.
Xiangqian Guan, Yuyan Lu, +5 authors, Zhenyu Yin.
J Hepatocell Carcinoma, 2021 May 29; 8. PMID: 34046369    Free PMC article.
Resolving the graft ischemia-reperfusion injury during liver transplantation at the single cell resolution.
Linhe Wang, Jie Li, +12 authors, Xiaoshun He.
Cell Death Dis, 2021 Jun 10; 12(6). PMID: 34103479    Free PMC article.
Applications of single-cell sequencing in cancer research: progress and perspectives.
Yalan Lei, Rong Tang, +5 authors, Si Shi.
J Hematol Oncol, 2021 Jun 11; 14(1). PMID: 34108022    Free PMC article.
Review.
Combination of molecularly targeted therapies and immune checkpoint inhibitors in the new era of unresectable hepatocellular carcinoma treatment.
Ze-Long Liu, Jing-Hua Liu, Daniel Staiculescu, Jiang Chen.
Ther Adv Med Oncol, 2021 Jun 10; 13. PMID: 34104226    Free PMC article.
Review.
The Endless Sources of Hepatocellular Carcinoma Heterogeneity.
Marina Barcena-Varela, Amaia Lujambio.
Cancers (Basel), 2021 Jun 03; 13(11). PMID: 34073538    Free PMC article.
Review.
Single-cell biology to decode the immune cellular composition of kidney inflammation.
Yu Zhao, Ulf Panzer, Stefan Bonn, Christian F Krebs.
Cell Tissue Res, 2021 Jun 15; 385(2). PMID: 34125286    Free PMC article.
Review.
Identification METTL18 as a Potential Prognosis Biomarker and Associated With Immune Infiltrates in Hepatocellular Carcinoma.
Tian-Hao Li, Cheng Qin, +6 authors, Wei-Bin Wang.
Front Oncol, 2021 Jun 15; 11. PMID: 34123827    Free PMC article.
Maintenance of the human memory T cell repertoire by subset and tissue site.
Michelle Miron, Wenzhao Meng, +7 authors, Donna L Farber.
Genome Med, 2021 Jun 16; 13(1). PMID: 34127056    Free PMC article.
Single-cell RNA sequencing shows the immunosuppressive landscape and tumor heterogeneity of HBV-associated hepatocellular carcinoma.
Daniel Wai-Hung Ho, Yu-Man Tsui, +14 authors, Irene Oi-Lin Ng.
Nat Commun, 2021 Jun 19; 12(1). PMID: 34140495    Free PMC article.
Signatures of B Cell Receptor Repertoire Following Pneumocystis Infection.
Han Sun, Hu-Qin Yang, Kan Zhai, Zhao-Hui Tong.
Front Microbiol, 2021 Jun 18; 12. PMID: 34135870    Free PMC article.
Neuromedin U and neurotensin may promote the development of the tumour microenvironment in neuroblastoma.
Daheng Yang, Xianwei Zhang, +3 authors, Hongbing Chen.
PeerJ, 2021 Jun 19; 9. PMID: 34141479    Free PMC article.
Liver Cancer Immunity.
Sumera Rizvi, Juan Wang, Anthony B El-Khoueiry.
Hepatology, 2020 Jun 10; 73 Suppl 1. PMID: 32516437    Free PMC article.
Review.
Recent Advancements in Nanomedicine for 'Cold' Tumor Immunotherapy.
Qinjun Chen, Tao Sun, Chen Jiang.
Nanomicro Lett, 2021 Jun 18; 13(1). PMID: 34138315    Free PMC article.
Review.
Single-cell transcriptomic analysis reveals disparate effector differentiation pathways in human Treg compartment.
Yuechen Luo, Changlu Xu, +18 authors, Xiaoming Feng.
Nat Commun, 2021 Jun 25; 12(1). PMID: 34162888    Free PMC article.
Exploring liver cancer biology through functional genetic screens.
Cun Wang, Ying Cao, +2 authors, Wenxin Qin.
Nat Rev Gastroenterol Hepatol, 2021 Jun 25; 18(10). PMID: 34163045
Review.
Peripheral CD8+ T cell characteristics associated with durable responses to immune checkpoint blockade in patients with metastatic melanoma.
Benjamin P Fairfax, Chelsea A Taylor, +12 authors, Mark R Middleton.
Nat Med, 2020 Feb 12; 26(2). PMID: 32042196    Free PMC article.
Single-Cell TCR and Transcriptome Analysis: An Indispensable Tool for Studying T-Cell Biology and Cancer Immunotherapy.
Anna Pasetto, Yong-Chen Lu.
Front Immunol, 2021 Jun 25; 12. PMID: 34163487    Free PMC article.
Review.
Intratumoral follicular regulatory T cells curtail anti-PD-1 treatment efficacy.
Simon Eschweiler, James Clarke, +14 authors, Pandurangan Vijayanand.
Nat Immunol, 2021 Jun 26; 22(8). PMID: 34168370    Free PMC article.
Natural Killer Cells and T Cells in Hepatocellular Carcinoma and Viral Hepatitis: Current Status and Perspectives for Future Immunotherapeutic Approaches.
Suresh Gopi Kalathil, Yasmin Thanavala.
Cells, 2021 Jun 03; 10(6). PMID: 34071188    Free PMC article.
Review.
Single-cell atlas of colonic CD8+ T cells in ulcerative colitis.
Daniele Corridoni, Agne Antanaviciute, +17 authors, Alison Simmons.
Nat Med, 2020 Aug 05; 26(9). PMID: 32747828
Applications of Single-Cell Omics in Tumor Immunology.
Junwei Liu, Saisi Qu, +5 authors, Weiwei Yin.
Front Immunol, 2021 Jun 29; 12. PMID: 34177965    Free PMC article.
Review.
Single-Cell Transcriptomics Reveals the Cellular Heterogeneity of Cardiovascular Diseases.
Mengxia Fu, Jiangping Song.
Front Cardiovasc Med, 2021 Jun 29; 8. PMID: 34179129    Free PMC article.
Review.
Resident and circulating memory T cells persist for years in melanoma patients with durable responses to immunotherapy.
Jichang Han, Yanding Zhao, +12 authors, Christina V Angeles.
Nat Cancer, 2021 Jun 29; 2(3). PMID: 34179824    Free PMC article.
Immune signature-based hepatocellular carcinoma subtypes may provide novel insights into therapy and prognosis predictions.
Qiuxian Zheng, Qin Yang, +5 authors, Zhi Chen.
Cancer Cell Int, 2021 Jul 02; 21(1). PMID: 34193146    Free PMC article.
An Immune-Related Prognostic Classifier Is Associated with Diffuse Large B Cell Lymphoma Microenvironment.
Xiao-Jie Liang, Rui-Ying Fu, +4 authors, Liang Wang.
J Immunol Res, 2021 Jul 03; 2021. PMID: 34212052    Free PMC article.
Discovering Cellular Mitochondrial Heteroplasmy Heterogeneity with Single Cell RNA and ATAC Sequencing.
Aidan S Marshall, Nick S Jones.
Biology (Basel), 2021 Jul 03; 10(6). PMID: 34198745    Free PMC article.
Review.
Novel Prognostic Biomarkers in Gastric Cancer: CGB5, MKNK2, and PAPPA2.
Min Qin, Zhihai Liang, +4 authors, Guodu Tang.
Front Oncol, 2021 Jul 06; 11. PMID: 34222004    Free PMC article.
Single-cell chromatin accessibility landscape of human umbilical cord blood in trisomy 18 syndrome.
Xiaofen Qiu, Haiyan Yu, +11 authors, Yong Dai.
Hum Genomics, 2021 Jul 02; 15(1). PMID: 34193281    Free PMC article.
Bardet-Biedl syndrome proteins regulate intracellular signaling and neuronal function in patient-specific iPSC-derived neurons.
Liheng Wang, Yang Liu, +16 authors, Rudolph L Leibel.
J Clin Invest, 2021 Feb 26; 131(8). PMID: 33630762    Free PMC article.
An m6A-Related Prognostic Biomarker Associated With the Hepatocellular Carcinoma Immune Microenvironment.
Yingxi Du, Yarui Ma, +4 authors, Xiaobing Wang.
Front Pharmacol, 2021 Jul 13; 12. PMID: 34248650    Free PMC article.
ASRGL1 Correlates With Immune Cell Infiltration in Hepatocellular Carcinoma and Can Serve as a Prognostic Biomarker.
Cailin Xue, Peng Gao, +5 authors, Xihu Qin.
Front Oncol, 2021 Jul 13; 11. PMID: 34249720    Free PMC article.
CD8+ T cell differentiation and dysfunction in cancer.
Mary Philip, Andrea Schietinger.
Nat Rev Immunol, 2021 Jul 14; 22(4). PMID: 34253904
Review.
Predictive potential of Nomogram based on GMWG for patients with hepatocellular carcinoma after radical resection.
Liying Ren, Dongbo Chen, +6 authors, Weijia Liao.
BMC Cancer, 2021 Jul 17; 21(1). PMID: 34266388    Free PMC article.
Construction and validation of a prognostic signature using CNV-driven genes for hepatocellular carcinoma.
Jin Bian, Junyu Long, +6 authors, Haitao Zhao.
Ann Transl Med, 2021 Jul 17; 9(9). PMID: 34268378    Free PMC article.
Bulk and single-cell transcriptome profiling reveal the metabolic heterogeneity in human breast cancers.
Tian-Jian Yu, Ding Ma, +6 authors, Gen-Hong Di.
Mol Ther, 2021 Mar 08; 29(7). PMID: 33677091    Free PMC article.
M2 macrophage-derived extracellular vesicles facilitate CD8+T cell exhaustion in hepatocellular carcinoma via the miR-21-5p/YOD1/YAP/β-catenin pathway.
Jian Pu, Zuoming Xu, +7 authors, Huamei Wei.
Cell Death Discov, 2021 Jul 21; 7(1). PMID: 34282135    Free PMC article.
Pivotal factors associated with the immunosuppressive tumor microenvironment and melanoma metastasis.
Chuan Zhang, Dan Dang, +2 authors, Xianling Cong.
Cancer Med, 2021 Jun 24; 10(14). PMID: 34159752    Free PMC article.
Prospects and Challenges for T Cell-Based Therapies of HCC.
Norman Woller, Sophie Anna Engelskircher, Thomas Wirth, Heiner Wedemeyer.
Cells, 2021 Jul 03; 10(7). PMID: 34209393    Free PMC article.
Review.
Antigen identification for HLA class I- and HLA class II-restricted T cell receptors using cytokine-capturing antigen-presenting cells.
Mark N Lee, Matthew Meyerson.
Sci Immunol, 2021 Jan 24; 6(55). PMID: 33483338    Free PMC article.
Genomic and transcriptomic profiling of hepatoid adenocarcinoma of the stomach.
Ziyang Liu, Anqiang Wang, +8 authors, Jiafu Ji.
Oncogene, 2021 Jul 31; 40(38). PMID: 34326469
MAIT cells regulate NK cell-mediated tumor immunity.
Emma V Petley, Hui-Fern Koay, +28 authors, Phillip K Darcy.
Nat Commun, 2021 Aug 08; 12(1). PMID: 34362900    Free PMC article.
Insights into an Immunotherapeutic Approach to Combat Multidrug Resistance in Hepatocellular Carcinoma.
Aswathy R Devan, Ayana R Kumar, +5 authors, Lekshmi R Nath.
Pharmaceuticals (Basel), 2021 Aug 07; 14(7). PMID: 34358082    Free PMC article.
Review.
Role of Oncogenic Pathways on the Cancer Immunosuppressive Microenvironment and Its Clinical Implications in Hepatocellular Carcinoma.
Naoshi Nishida.
Cancers (Basel), 2021 Aug 08; 13(15). PMID: 34359568    Free PMC article.
Review.
Antigen-Specific Treg Therapy in Type 1 Diabetes - Challenges and Opportunities.
Isabelle Serr, Felix Drost, Benjamin Schubert, Carolin Daniel.
Front Immunol, 2021 Aug 10; 12. PMID: 34367177    Free PMC article.
Review.
Immunotherapy against programmed death-1/programmed death ligand 1 in hepatocellular carcinoma: Importance of molecular variations, cellular heterogeneity, and cancer stem cells.
Caecilia H C Sukowati, Korri Elvanita El-Khobar, Claudio Tiribelli.
World J Stem Cells, 2021 Aug 10; 13(7). PMID: 34367478    Free PMC article.
Review.
Cellular based immunotherapy for primary liver cancer.
Yuanyuan Zheng, Yan Li, +8 authors, Chuanyong Guo.
J Exp Clin Cancer Res, 2021 Aug 11; 40(1). PMID: 34372912    Free PMC article.
Review.
Interleukin-2 inducible T-cell kinase: a potential prognostic biomarker and tumor microenvironment remodeling indicator for hepatocellular carcinoma.
Binhua Pan, Modan Yang, +7 authors, Xiao Xu.
Aging (Albany NY), 2021 Jul 21; 13(14). PMID: 34282055    Free PMC article.
Human MAIT cells endowed with HBV specificity are cytotoxic and migrate towards HBV-HCC while retaining antimicrobial functions.
Katie Healy, Andrea Pavesi, +8 authors, Margaret Sällberg Chen.
JHEP Rep, 2021 Aug 12; 3(4). PMID: 34377970    Free PMC article.
Single-Cell RNA Sequencing of Retina:New Looks for Gene Marker and Old Diseases.
Peixi Ying, Chang Huang, +7 authors, Min Fu.
Front Mol Biosci, 2021 Aug 17; 8. PMID: 34395530    Free PMC article.
Review.
Immune suppressive checkpoint interactions in the tumour microenvironment of primary liver cancers.
Guoying Zhou, Patrick P C Boor, +2 authors, Jaap Kwekkeboom.
Br J Cancer, 2021 Aug 18; 126(1). PMID: 34400801    Free PMC article.
Review.
Cancer biology deciphered by single-cell transcriptomic sequencing.
Yanmeng Li, Jianshi Jin, Fan Bai.
Protein Cell, 2021 Aug 19; 13(3). PMID: 34405376    Free PMC article.
Review.
Inferring single cell expression profiles from overlapped pooling sequencing data with compressed sensing strategy.
Mengting Huang, Yixuan Yang, +5 authors, Zuhong Lu.
Nucleic Acids Res, 2021 Jul 11; 49(14). PMID: 34244789    Free PMC article.
MultiK: an automated tool to determine optimal cluster numbers in single-cell RNA sequencing data.
Siyao Liu, Aatish Thennavan, +2 authors, Charles M Perou.
Genome Biol, 2021 Aug 21; 22(1). PMID: 34412669    Free PMC article.
HHLA2 Expression is Associated with Poor Survival in Patients with Hepatocellular Carcinoma.
Yituo Xu, Zhijie Huang, +3 authors, Jing Xu.
Biologics, 2021 Aug 21; 15. PMID: 34413629    Free PMC article.
Exploring Markers of Exhausted CD8 T Cells to Predict Response to Immune Checkpoint Inhibitor Therapy for Hepatocellular Carcinoma.
Chia-Lang Hsu, Da-Liang Ou, +6 authors, Chiun Hsu.
Liver Cancer, 2021 Aug 21; 10(4). PMID: 34414122    Free PMC article.
Technological advances in cancer immunity: from immunogenomics to single-cell analysis and artificial intelligence.
Ying Xu, Guan-Hua Su, +3 authors, Yi-Zhou Jiang.
Signal Transduct Target Ther, 2021 Aug 22; 6(1). PMID: 34417437    Free PMC article.
Review.
Integrating T cell receptor sequences and transcriptional profiles by clonotype neighbor graph analysis (CoNGA).
Stefan A Schattgen, Kate Guion, +5 authors, Philip Bradley.
Nat Biotechnol, 2021 Aug 25; 40(1). PMID: 34426704    Free PMC article.
Single-Cell Profiling Explore the Immunologic Mechanisms of Tumor Relapse in Hepatocellular Carcinoma.
Liyi Zhang.
Glob Med Genet, 2021 Aug 26; 8(3). PMID: 34430957    Free PMC article.
Comprehensive Analyses of the Infiltrating Immune Cell Landscape and Its Clinical Significance in Hepatocellular Carcinoma.
Zeyu Zhang, Zhiming Wang, Yun Huang.
Int J Gen Med, 2021 Aug 28; 14. PMID: 34447264    Free PMC article.
IgG Immune Complexes Inhibit Naïve T Cell Proliferation and Suppress Effector Function in Cytotoxic T Cells.
Wissam Charab, Matthew G Rosenberger, +8 authors, George Georgiou.
Front Immunol, 2021 Aug 28; 12. PMID: 34447380    Free PMC article.
Tissue-Resident T Cells in Chronic Relapsing-Remitting Intestinal Disorders.
Juliana Barreto de Albuquerque, Christoph Mueller, Bilgi Gungor.
Cells, 2021 Aug 28; 10(8). PMID: 34440651    Free PMC article.
Review.
The State of Immunotherapy in Hepatobiliary Cancers.
Farhan Z Ilyas, Joal D Beane, Timothy M Pawlik.
Cells, 2021 Aug 28; 10(8). PMID: 34440865    Free PMC article.
Review.
From bench to bedside: Single-cell analysis for cancer immunotherapy.
Emily F Davis-Marcisak, Atul Deshpande, +5 authors, Luciane T Kagohara.
Cancer Cell, 2021 Jul 31; 39(8). PMID: 34329587    Free PMC article.
Review.
Applying high-dimensional single-cell technologies to the analysis of cancer immunotherapy.
Satyen H Gohil, J Bryan Iorgulescu, +2 authors, Kenneth J Livak.
Nat Rev Clin Oncol, 2020 Dec 06; 18(4). PMID: 33277626    Free PMC article.
Review.
B-Cell Compartmental Features and Molecular Basis for Therapy in Autoimmune Disease.
Chao Zhang, Tian-Xiang Zhang, +7 authors, Fu-Dong Shi.
Neurol Neuroimmunol Neuroinflamm, 2021 Sep 02; 8(6). PMID: 34465614    Free PMC article.
A single-cell atlas of liver metastases of colorectal cancer reveals reprogramming of the tumor microenvironment in response to preoperative chemotherapy.
Li-Heng Che, Jing-Wen Liu, +14 authors, Jian-Ming Li.
Cell Discov, 2021 Sep 08; 7(1). PMID: 34489408    Free PMC article.
Autoimmunity affecting the biliary tract fuels the immunosurveillance of cholangiocarcinoma.
Juliette Paillet, Céleste Plantureux, +33 authors, Jonathan G Pol.
J Exp Med, 2021 Sep 09; 218(10). PMID: 34495298    Free PMC article.
Single-Cell RNA Sequencing Reveals the Migration of Osteoclasts in Giant Cell Tumor of Bone.
Wenyu Feng, Mingwei He, +11 authors, Qingjun Wei.
Front Oncol, 2021 Sep 11; 11. PMID: 34504794    Free PMC article.
Genetic Heterogeneity, Therapeutic Hurdle Confronting Sorafenib and Immune Checkpoint Inhibitors in Hepatocellular Carcinoma.
Sara M Atwa, Margarete Odenthal, Hend M El Tayebi.
Cancers (Basel), 2021 Sep 11; 13(17). PMID: 34503153    Free PMC article.
Review.
Identification and Characterization of Robust Hepatocellular Carcinoma Prognostic Subtypes Based on an Integrative Metabolite-Protein Interaction Network.
Di Chen, Yiran Zhang, +17 authors, Hai-Long Piao.
Adv Sci (Weinh), 2021 Jul 12; 8(17). PMID: 34247449    Free PMC article.
Pan-cancer analysis and single-cell analysis revealed the role of ABCC5 transporter in hepatocellular carcinoma.
Liang Chen, Zhonghua Yang, +6 authors, Hongzhu Yu.
Channels (Austin), 2021 Sep 09; 15(1). PMID: 34494510    Free PMC article.
Schrödinger's T Cells: Molecular Insights Into Stemness and Exhaustion.
Nancy M Gonzalez, Dawei Zou, Andy Gu, Wenhao Chen.
Front Immunol, 2021 Sep 14; 12. PMID: 34512656    Free PMC article.
Review.
SCISSOR™: a single-cell inferred site-specific omics resource for tumor microenvironment association study.
Xiang Cui, Fei Qin, +2 authors, Guoshuai Cai.
NAR Cancer, 2021 Sep 14; 3(3). PMID: 34514416    Free PMC article.
Advancing to the era of cancer immunotherapy.
Yun Wang, Min Wang, Hao-Xiang Wu, Rui-Hua Xu.
Cancer Commun (Lond), 2021 Jun 25; 41(9). PMID: 34165252    Free PMC article.
Review.
GDF15 induces immunosuppression via CD48 on regulatory T cells in hepatocellular carcinoma.
Zhaowei Wang, Lei He, +19 authors, Meng Li.
J Immunother Cancer, 2021 Sep 08; 9(9). PMID: 34489334    Free PMC article.
Biomarkers and Future Perspectives for Hepatocellular Carcinoma Immunotherapy.
Yuqing He, Mengyao Lu, +3 authors, Yuan Chen.
Front Oncol, 2021 Sep 24; 11. PMID: 34552872    Free PMC article.
Review.
Mechanism of action of PD-1 receptor/ligand targeted cancer immunotherapy.
Jannie Borst, Julia Busselaar, Douwe M T Bosma, Ferry Ossendorp.
Eur J Immunol, 2021 Jun 10; 51(8). PMID: 34106465    Free PMC article.
Review.
A preliminary investigation into the immune cell landscape of schistosome-associated liver fibrosis in humans.
Yu Zhang, Junhui Li, +4 authors, Yingzi Ming.
Immunol Cell Biol, 2021 Aug 07; 99(8). PMID: 34355810    Free PMC article.
Systematic investigation of cytokine signaling activity at the tissue and single-cell levels.
Peng Jiang, Yu Zhang, +9 authors, Kai W Wucherpfennig.
Nat Methods, 2021 Oct 02; 18(10). PMID: 34594031    Free PMC article.
CD177 modulates the function and homeostasis of tumor-infiltrating regulatory T cells.
Myung-Chul Kim, Nicholas Borcherding, +32 authors, Weizhou Zhang.
Nat Commun, 2021 Oct 03; 12(1). PMID: 34599187    Free PMC article.
Layilin Anchors Regulatory T Cells in Skin.
Pooja Mehta, Victoire Gouirand, +20 authors, Michael D Rosenblum.
J Immunol, 2021 Sep 03; 207(7). PMID: 34470859    Free PMC article.
Immunotherapeutic Potential of T Memory Stem Cells.
Yujie Li, Dengqiang Wu, Xuejia Yang, Sufang Zhou.
Front Oncol, 2021 Oct 05; 11. PMID: 34604060    Free PMC article.
Review.
The GPR171 pathway suppresses T cell activation and limits antitumor immunity.
Yuki Fujiwara, Robert J Torphy, +8 authors, Yuwen Zhu.
Nat Commun, 2021 Oct 08; 12(1). PMID: 34615877    Free PMC article.
Human tissue cultures of lung cancer predict patient susceptibility to immune-checkpoint inhibition.
David Junk, Sebastian Krämer, +10 authors, Sonja Kallendrusch.
Cell Death Discov, 2021 Sep 27; 7(1). PMID: 34564709    Free PMC article.
Effector T cell responses unleashed by regulatory T cell ablation exacerbate oral squamous cell carcinoma.
Jaime L Chao, Michael Korzinkin, +6 authors, Peter A Savage.
Cell Rep Med, 2021 Oct 09; 2(9). PMID: 34622236    Free PMC article.
In vitro 3D liver tumor microenvironment models for immune cell therapy optimization.
Maxine Lam, Jose Antonio Reales-Calderon, +2 authors, Andrea Pavesi.
APL Bioeng, 2021 Oct 12; 5(4). PMID: 34632251    Free PMC article.
Review.
Single-Cell RNA-Seq of T Cells in B-ALL Patients Reveals an Exhausted Subset with Remarkable Heterogeneity.
Xiaofang Wang, Yanjuan Chen, +8 authors, Yangqiu Li.
Adv Sci (Weinh), 2021 Aug 09; 8(19). PMID: 34365737    Free PMC article.
Construction and Validation of an Immune Cell Signature Score to Evaluate Prognosis and Therapeutic Efficacy in Hepatocellular Carcinoma.
Linfeng Xu, Xingxing Jian, +4 authors, Lu Xie.
Front Genet, 2021 Oct 15; 12. PMID: 34646307    Free PMC article.
Drug-Induced Resistance and Phenotypic Switch in Triple-Negative Breast Cancer Can Be Controlled via Resolution and Targeting of Individualized Signaling Signatures.
Swetha Vasudevan, Ibukun A Adejumobi, +4 authors, Nataly Kravchenko-Balasha.
Cancers (Basel), 2021 Oct 14; 13(19). PMID: 34638492    Free PMC article.
Single-cell transcriptomic analysis of the tumor ecosystems underlying initiation and progression of papillary thyroid carcinoma.
Weilin Pu, Xiao Shi, +18 authors, Yu-Long Wang.
Nat Commun, 2021 Oct 20; 12(1). PMID: 34663816    Free PMC article.
Atlas of clinically distinct cell states and ecosystems across human solid tumors.
Bogdan A Luca, Chloé B Steen, +10 authors, Aaron M Newman.
Cell, 2021 Oct 02; 184(21). PMID: 34597583    Free PMC article.
CD161, a promising Immune Checkpoint, correlates with Patient Prognosis: A Pan-cancer Analysis.
Wenrui Ye, Cong Luo, +2 authors, Fangkun Liu.
J Cancer, 2021 Oct 19; 12(21). PMID: 34659549    Free PMC article.
Development and Verification of an Immune-Related Gene Pairs Prognostic Signature in Hepatocellular Carcinoma.
Xiaofei Feng, Shanshan Mu, Yao Ma, Wenji Wang.
Front Mol Biosci, 2021 Oct 19; 8. PMID: 34660693    Free PMC article.
Single-Cell Analysis of the Multicellular Ecosystem in Viral Carcinogenesis by HTLV-1.
Junji Koya, Yuki Saito, +20 authors, Keisuke Kataoka.
Blood Cancer Discov, 2021 Oct 19; 2(5). PMID: 34661162    Free PMC article.
Single-cell RNA sequencing reveals spatiotemporal heterogeneity and malignant progression in pancreatic neuroendocrine tumor.
Yu Zhou, Siyang Liu, +6 authors, Rufu Chen.
Int J Biol Sci, 2021 Oct 22; 17(14). PMID: 34671197    Free PMC article.
Knowledge-based classification of fine-grained immune cell types in single-cell RNA-Seq data.
Xuan Liu, Sara J C Gosline, +5 authors, Jeffrey T Chang.
Brief Bioinform, 2021 Mar 09; 22(5). PMID: 33681983    Free PMC article.
Aortic heterogeneity across segments and under high fat/salt/glucose conditions at the single-cell level.
Dongxu He, Aiqin Mao, +5 authors, Xin Ma.
Natl Sci Rev, 2020 May 01; 7(5). PMID: 34692110    Free PMC article.
Crosstalk Between the Tumor Microenvironment and Cancer Cells: A Promising Predictive Biomarker for Immune Checkpoint Inhibitors.
Xiaoying Li, Yueyao Yang, +4 authors, Ming Liu.
Front Cell Dev Biol, 2021 Oct 26; 9. PMID: 34692696    Free PMC article.
Review.
Single-cell sequencing reveals antitumor characteristics of intratumoral immune cells in old mice.
Cangang Zhang, Lei Lei, +14 authors, Baojun Zhang.
J Immunother Cancer, 2021 Oct 14; 9(10). PMID: 34642245    Free PMC article.
Rapid Identification of the Tumor-Specific Reactive TIL Repertoire via Combined Detection of CD137, TNF, and IFNγ, Following Recognition of Autologous Tumor-Antigens.
Arianna Draghi, Christopher Aled Chamberlain, +16 authors, Marco Donia.
Front Immunol, 2021 Oct 29; 12. PMID: 34707600    Free PMC article.
Integrating single cell sequencing with a spatial quantitative systems pharmacology model spQSP for personalized prediction of triple-negative breast cancer immunotherapy response.
Shuming Zhang, Chang Gong, +5 authors, Elana J Fertig.
Immunoinformatics (Amst), 2021 Oct 29; 1-2. PMID: 34708216    Free PMC article.
Miscell: An efficient self-supervised learning approach for dissecting single-cell transcriptome.
Hongru Shen, Yang Li, +13 authors, Xiangchun Li.
iScience, 2021 Oct 30; 24(11). PMID: 34712916    Free PMC article.
Phased differentiation of γδ T and T CD8 tumor-infiltrating lymphocytes revealed by single-cell transcriptomics of human cancers.
Juan-Pablo Cerapio, Marion Perrier, +15 authors, Jean-Jacques Fournie.
Oncoimmunology, 2021 Nov 02; 10(1). PMID: 34721945    Free PMC article.
Application of Single-Cell Multi-Omics in Dissecting Cancer Cell Plasticity and Tumor Heterogeneity.
Deshen Pan, Deshui Jia.
Front Mol Biosci, 2021 Nov 02; 8. PMID: 34722635    Free PMC article.
Review.
Exhaustion in tumor-infiltrating Mucosal-Associated Invariant T (MAIT) cells from colon cancer patients.
William Rodin, Patrik Sundström, +5 authors, Marianne Quiding Järbrink.
Cancer Immunol Immunother, 2021 Apr 23; 70(12). PMID: 33885944    Free PMC article.
Immunogenomic Landscape Analysis of Prognostic Immune-Related Genes in Hepatocellular Carcinoma.
Peng Qin, Mengyu Zhang, Xue Liu, Ziming Dong.
J Healthc Eng, 2021 Nov 09; 2021. PMID: 34745496    Free PMC article.
The Single-Cell Sequencing: A Dazzling Light Shining on the Dark Corner of Cancer.
Jing Li, Nan Yu, +2 authors, Qie Guo.
Front Oncol, 2021 Nov 09; 11. PMID: 34745998    Free PMC article.
Review.
The Single-Cell Transcriptomic Analysis of Prefrontal Pyramidal Cells and Interneurons Reveals the Neuronal Expression of Genes Encoding Antimicrobial Peptides and Immune Proteins.
Dániel Mittli, Vanda Tukacs, +4 authors, Katalin Adrienna Kékesi.
Front Immunol, 2021 Nov 12; 12. PMID: 34759929    Free PMC article.
Deciphering cell lineage specification of human lung adenocarcinoma with single-cell RNA sequencing.
Zhoufeng Wang, Zhe Li, +16 authors, Weimin Li.
Nat Commun, 2021 Nov 13; 12(1). PMID: 34764257    Free PMC article.
Immunotherapies for hepatocellular carcinoma.
Josep M Llovet, Florian Castet, +6 authors, Richard S Finn.
Nat Rev Clin Oncol, 2021 Nov 13; 19(3). PMID: 34764464
Review.
Intrinsic and Extrinsic Control of Hepatocellular Carcinoma by TAM Receptors.
Viola Hedrich, Kristina Breitenecker, +2 authors, Wolfgang Mikulits.
Cancers (Basel), 2021 Nov 14; 13(21). PMID: 34771611    Free PMC article.
Review.
Intratumor Heterogeneity in Hepatocellular Carcinoma: Challenges and Opportunities.
Sharanya Maanasi Kalasekar, Chad H VanSant-Webb, Kimberley J Evason.
Cancers (Basel), 2021 Nov 14; 13(21). PMID: 34771685    Free PMC article.
Review.
Dynamic regulatory networks of T cell trajectory dissect transcriptional control of T cell state transition.
Min Yan, Jing Hu, +9 authors, Xia Li.
Mol Ther Nucleic Acids, 2021 Nov 18; 26. PMID: 34786214    Free PMC article.
Application of single-cell RNA sequencing technology in liver diseases: a narrative review.
Lian He, Anjing Lu, +4 authors, Yuqi He.
Ann Transl Med, 2021 Nov 19; 9(20). PMID: 34790804    Free PMC article.
Review.
Single-cell analysis of diverse immune phenotypes in malignant pleural effusion.
Zhong-Yin Huang, Ming-Ming Shao, +9 authors, Huan-Zhong Shi.
Nat Commun, 2021 Nov 20; 12(1). PMID: 34795282    Free PMC article.
mTOR-dependent translation drives tumor infiltrating CD8+ effector and CD4+ Treg cells expansion.
Benedetta De Ponte Conti, Annarita Miluzio, +3 authors, Sara Ricciardi.
Elife, 2021 Nov 18; 10. PMID: 34787568    Free PMC article.
Spatial transcriptomics reveals gene expression characteristics in invasive micropapillary carcinoma of the breast.
Jianke Lv, Qianqian Shi, +11 authors, Li Fu.
Cell Death Dis, 2021 Nov 21; 12(12). PMID: 34799559    Free PMC article.
Single-cell atlas of tumor cell evolution in response to therapy in hepatocellular carcinoma and intrahepatic cholangiocarcinoma.
Lichun Ma, Limin Wang, +15 authors, Xin Wei Wang.
J Hepatol, 2021 Jul 04; 75(6). PMID: 34216724    Free PMC article.
Deciphering the Intercellular Communication Network of Peripartum Decidua that Orchestrates Delivery.
Jingrui Huang, Weishe Zhang, +7 authors, Lei Dai.
Front Cell Dev Biol, 2021 Nov 23; 9. PMID: 34805176    Free PMC article.
Direct Comparative Analyses of 10X Genomics Chromium and Smart-seq2.
Xiliang Wang, Yao He, +2 authors, Zemin Zhang.
Genomics Proteomics Bioinformatics, 2021 Mar 05; 19(2). PMID: 33662621    Free PMC article.
Exposure to Tobacco Smoking Induces a subset of Activated Tumor-resident Tregs in Non-Small Cell Lung Cancer.
Yudi Hu, Chaoqun Xu, +6 authors, Qiyuan Li.
Transl Oncol, 2021 Nov 13; 15(1). PMID: 34768099    Free PMC article.
Neoadjuvant PD-1 blockade induces T cell and cDC1 activation but fails to overcome the immunosuppressive tumor associated macrophages in recurrent glioblastoma.
Alexander H Lee, Lu Sun, +11 authors, Robert M Prins.
Nat Commun, 2021 Nov 28; 12(1). PMID: 34836966    Free PMC article.
Targeted Anti-Tumor Immunotherapy Using Tumor Infiltrating Cells.
Yifan Xie, Feng Xie, +7 authors, Fangfang Zhou.
Adv Sci (Weinh), 2021 Oct 19; 8(22). PMID: 34658167    Free PMC article.
Review.
Activated but impaired IFN-γ production of mucosal-associated invariant T cells in patients with hepatocellular carcinoma.
Wenyong Huang, Dongmei Ye, +3 authors, Yifang Gao.
J Immunother Cancer, 2021 Nov 19; 9(11). PMID: 34789552    Free PMC article.
Amplification of spatially isolated adenosine pathway by tumor-macrophage interaction induces anti-PD1 resistance in hepatocellular carcinoma.
Jia-Cheng Lu, Peng-Fei Zhang, +12 authors, Jia Fan.
J Hematol Oncol, 2021 Nov 29; 14(1). PMID: 34838121    Free PMC article.
RNA-Binding Protein Expression Alters Upon Differentiation of Human B Cells and T Cells.
Nordin D Zandhuis, Benoit P Nicolet, Monika C Wolkers.
Front Immunol, 2021 Dec 07; 12. PMID: 34867946    Free PMC article.
Targeting Immune Cells in the Tumor Microenvironment of HCC: New Opportunities and Challenges.
Xiaopei Hao, Guangshun Sun, +5 authors, Xuehao Wang.
Front Cell Dev Biol, 2021 Dec 07; 9. PMID: 34869376    Free PMC article.
Review.
Targeting T Cell Subtypes for NAFLD and NAFLD-Related HCC Treatment: An Opinion.
Chunye Zhang, Ming Yang.
Front Med (Lausanne), 2021 Dec 07; 8. PMID: 34869507    Free PMC article.
Application and prospects of single cell sequencing in tumors.
Ruo Han Huang, Le Xin Wang, Jing He, Wen Gao.
Biomark Res, 2021 Dec 14; 9(1). PMID: 34895349    Free PMC article.
Review.
Single-Cell RNA Sequencing Reveals the Heterogeneity of Infiltrating Immune Cell Profiles in the Hepatic Cystic Echinococcosis Microenvironment.
Aimaiti Yasen, Wujianan Sun, +13 authors, Hao Wen.
Infect Immun, 2021 Sep 08; 89(12). PMID: 34491790    Free PMC article.
Multiplex imaging reveals the architecture of the tumor immune microenvironment.
Junlei Zhang, Jinyuan Song, +2 authors, Tingbo Liang.
Cancer Biol Med, 2021 Oct 29;. PMID: 34709000    Free PMC article.
Identification of molecular subtypes and prognostic signature for hepatocellular carcinoma based on genes associated with homologous recombination deficiency.
Hongsheng Lin, Yangyi Xie, +2 authors, Mingfen Li.
Sci Rep, 2021 Dec 17; 11(1). PMID: 34912005    Free PMC article.
Expansion of tumor-associated Treg cells upon disruption of a CTLA-4-dependent feedback loop.
Francesco Marangoni, Ademi Zhakyp, +10 authors, Thorsten R Mempel.
Cell, 2021 Jun 23; 184(15). PMID: 34157302    Free PMC article.
CREM Is Correlated With Immune-Suppressive Microenvironment and Predicts Poor Prognosis in Gastric Adenocarcinoma.
Kuai Yu, Linju Kuang, +6 authors, Aiping Le.
Front Cell Dev Biol, 2021 Dec 24; 9. PMID: 34938728    Free PMC article.
Immunotherapy for Hepatocellular Carcinoma: New Prospects for the Cancer Therapy.
Rossella Fasano, Mahdi Abdoli Shadbad, +6 authors, Nicola Silvestris.
Life (Basel), 2021 Dec 25; 11(12). PMID: 34947886    Free PMC article.
Review.
Single-Cell Transcriptome Analysis Reveals RGS1 as a New Marker and Promoting Factor for T-Cell Exhaustion in Multiple Cancers.
Yunmeng Bai, Meiling Hu, +2 authors, Hongli Du.
Front Immunol, 2021 Dec 28; 12. PMID: 34956194    Free PMC article.
Key Candidate Prognostic Biomarkers Correlated with Immune Infiltration in Hepatocellular Carcinoma.
Zenghua Deng, Kanghua Huang, +7 authors, Jirun Peng.
J Hepatocell Carcinoma, 2021 Dec 28; 8. PMID: 34956967    Free PMC article.
Comprehensive analysis of spatial architecture in primary liver cancer.
Rui Wu, Wenbo Guo, +26 authors, Lei Chen.
Sci Adv, 2021 Dec 18; 7(51). PMID: 34919432    Free PMC article.
Immunosuppression and outcomes in adult patients with de novo acute myeloid leukemia with normal karyotypes.
Francesca Ferraro, Christopher A Miller, +24 authors, Timothy J Ley.
Proc Natl Acad Sci U S A, 2021 Dec 01; 118(49). PMID: 34845035    Free PMC article.
CancerSCEM: a database of single-cell expression map across various human cancers.
Jingyao Zeng, Yadong Zhang, +9 authors, Jingfa Xiao.
Nucleic Acids Res, 2021 Oct 14; 50(D1). PMID: 34643725    Free PMC article.
Single-cell transcriptomics reveals opposing roles of Shp2 in Myc-driven liver tumor cells and microenvironment.
Wendy S Chen, Yan Liang, +5 authors, Gen-Sheng Feng.
Cell Rep, 2021 Nov 11; 37(6). PMID: 34758313    Free PMC article.
Current Perspectives on the Immunosuppressive Niche and Role of Fibrosis in Hepatocellular Carcinoma and the Development of Antitumor Immunity.
Tomoko Aoki, Naoshi Nishida, Masatoshi Kudo.
J Histochem Cytochem, 2021 Nov 10; 70(1). PMID: 34751050    Free PMC article.
Review.
Tumor-Associated Regulatory T Cell Expression of LAIR2 Is Prognostic in Lung Adenocarcinoma.
Dalam Ly, Quan Li, +6 authors, Li Zhang.
Cancers (Basel), 2022 Jan 12; 14(1). PMID: 35008369    Free PMC article.
Single-Cell RNA-Seq Technologies and Computational Analysis Tools: Application in Cancer Research.
Qianqian Song, Liang Liu.
Methods Mol Biol, 2022 Jan 20; 2413. PMID: 35044670
Review.
Tissue-specific Tregs in cancer metastasis: opportunities for precision immunotherapy.
Laura A Huppert, Michael D Green, +4 authors, James C Lee.
Cell Mol Immunol, 2021 Aug 22; 19(1). PMID: 34417572    Free PMC article.
Review.
Single-Cell RNA Sequencing Reveals the Role of Phosphorylation-Related Genes in Hepatocellular Carcinoma Stem Cells.
Fuwen Yao, Yongqiang Zhan, +12 authors, Lisha Mou.
Front Cell Dev Biol, 2022 Jan 22; 9. PMID: 35059393    Free PMC article.
Prognostic Landscape of Tumor-Infiltrating T and B Cells in Human Cancer.
Ming Zheng, Yi-Ming Li, +7 authors, Zhi-Nan Chen.
Front Immunol, 2022 Jan 25; 12. PMID: 35069521    Free PMC article.
Multi-Omics Analysis of the Gut-Liver Axis Reveals the Mechanism of Liver Injury in Colitis Mice.
Luoyi Zhu, Xin Zong, +6 authors, Yizhen Wang.
Front Immunol, 2022 Jan 25; 12. PMID: 35069545    Free PMC article.
CD26/DPP4 as a Therapeutic Target in Nonalcoholic Steatohepatitis Associated Hepatocellular Carcinoma.
Sohji Nishina, Keisuke Hino.
Cancers (Basel), 2022 Jan 22; 14(2). PMID: 35053615    Free PMC article.
Review.
Dissecting the heterogeneity of the microenvironment in primary and recurrent nasopharyngeal carcinomas using single-cell RNA sequencing.
Wen-Sa Peng, Xin Zhou, +9 authors, Chao-Su Hu.
Oncoimmunology, 2022 Feb 01; 11(1). PMID: 35096485    Free PMC article.
The Emerging Role of Tissue-Resident Memory CD8+ T Lymphocytes in Human Digestive Tract Cancers.
Xinyu Mei, Huan Li, +2 authors, Kele Cui.
Front Oncol, 2022 Feb 01; 11. PMID: 35096624    Free PMC article.
Review.
An atlas of dynamic peripheral blood mononuclear cell landscapes in human perioperative anaesthesia/surgery.
Yang-Yang Wang, En-Qiang Chang, +8 authors, Jia-Qiang Zhang.
Clin Transl Med, 2022 Jan 22; 12(1). PMID: 35061932    Free PMC article.
Single-cell immune profiling reveals functional diversity of T cells in tuberculous pleural effusion.
Yi Cai, Yejun Wang, +13 authors, Xinchun Chen.
J Exp Med, 2022 Jan 22; 219(3). PMID: 35061012    Free PMC article.
Selective delivery of low-affinity IL-2 to PD-1+ T cells rejuvenates antitumor immunity with reduced toxicity.
Zhenhua Ren, Anli Zhang, +5 authors, Yang-Xin Fu.
J Clin Invest, 2022 Feb 02; 132(3). PMID: 35104810    Free PMC article.
Low expression of AQP9 and its value in hepatocellular carcinoma.
Cheng Gao, Jianbo Shen, +4 authors, Zhong Chen.
Transl Cancer Res, 2022 Feb 05; 10(4). PMID: 35116505    Free PMC article.
Prudent application of single-cell RNA sequencing in understanding cellular features and functional phenotypes in cancer studies.
Xuanhao Xu, Zemin Zhang.
Chin J Cancer Res, 2022 Feb 08; 33(6). PMID: 35125815    Free PMC article.
Genetic Alteration, Prognostic and Immunological Role of Acyl-CoA Synthetase Long-Chain Family Member 4 in a Pan-Cancer Analysis.
Yongsheng Yu, Xuepu Sun, Fei Chen, Miao Liu.
Front Genet, 2022 Feb 08; 13. PMID: 35126480    Free PMC article.
Evaluating tumor-infiltrating lymphocytes in hepatocellular carcinoma using hematoxylin and eosin-stained tumor sections.
Min Du, Yu-Meng Cai, +2 authors, Yuan Ji.
World J Clin Cases, 2022 Feb 08; 10(3). PMID: 35127901    Free PMC article.
CD161 expression and regulation defines rapidly responding effector CD4+ T cells associated with improved survival in HPV16-associated tumors.
Chantal L Duurland, Saskia J Santegoets, +14 authors, Sjoerd H van der Burg.
J Immunother Cancer, 2022 Jan 19; 10(1). PMID: 35039463    Free PMC article.
Single-cell transcriptomics reveals a low CD8+ T cell infiltrating state mediated by fibroblasts in recurrent renal cell carcinoma.
Yu-Lu Peng, Long-Bin Xiong, +19 authors, Zhi-Ling Zhang.
J Immunother Cancer, 2022 Feb 06; 10(2). PMID: 35121646    Free PMC article.
An NK-like CAR T cell transition in CAR T cell dysfunction.
Charly R Good, M Angela Aznar, +27 authors, Carl H June.
Cell, 2021 Dec 04; 184(25). PMID: 34861191    Free PMC article.
Anti-tumor effect of ginkgetin on human hepatocellular carcinoma cell lines by inducing cell cycle arrest and promoting cell apoptosis.
Qiong Liu, Lingying Chen, +3 authors, Xin Yang.
Cell Cycle, 2021 Dec 09; 21(1). PMID: 34878966    Free PMC article.
PD-L1+CD8+ T cells enrichment in lung cancer exerted regulatory function and tumor-promoting tolerance.
Yingxia Zheng, Li Han, +10 authors, Lisong Shen.
iScience, 2022 Feb 12; 25(2). PMID: 35146396    Free PMC article.
Revealing Clonal Responses of Tumor-Reactive T-Cells Through T Cell Receptor Repertoire Analysis.
Hiroyasu Aoki, Shigeyuki Shichino, Kouji Matsushima, Satoshi Ueha.
Front Immunol, 2022 Feb 15; 13. PMID: 35154125    Free PMC article.
Review.
T-cell dysfunction in the glioblastoma microenvironment is mediated by myeloid cells releasing interleukin-10.
Vidhya M Ravi, Nicolas Neidert, +25 authors, Dieter Henrik Heiland.
Nat Commun, 2022 Feb 19; 13(1). PMID: 35177622    Free PMC article.
Chemokine Receptor-Targeted Therapies: Special Case for CCR8.
Bernhard Moser.
Cancers (Basel), 2022 Feb 16; 14(3). PMID: 35158783    Free PMC article.
Review.
An Overview on Single-Cell Technology for Hepatocellular Carcinoma Diagnosis.
Sheik Aliya, Hoomin Lee, +2 authors, Yun Suk Huh.
Int J Mol Sci, 2022 Feb 16; 23(3). PMID: 35163329    Free PMC article.
Review.
Ulcerative colitis is characterized by a plasmablast-skewed humoral response associated with disease activity.
Mathieu Uzzan, Jerome C Martin, +53 authors, Saurabh Mehandru.
Nat Med, 2022 Feb 23; 28(4). PMID: 35190725    Free PMC article.
Myeloid antigen-presenting cell niches sustain antitumor T cells and license PD-1 blockade via CD28 costimulation.
Jaikumar Duraiswamy, Riccardo Turrini, +33 authors, George Coukos.
Cancer Cell, 2021 Nov 06; 39(12). PMID: 34739845    Free PMC article.
Prognostic and Clinical Significance of Aspartate Aminotransferase-to-Lymphocyte Ratio Index in Individuals with Liver Cancer: A Meta-Analysis.
Xiulan Peng, Yali Huang, +4 authors, Renfeng Luo.
Dis Markers, 2022 Feb 22; 2022. PMID: 35186165    Free PMC article.
Survival Genie, a web platform for survival analysis across pediatric and adult cancers.
Bhakti Dwivedi, Hope Mumme, +2 authors, Manoj Bhasin.
Sci Rep, 2022 Feb 25; 12(1). PMID: 35197510    Free PMC article.
Single-cell multiomics reveals heterogeneous cell states linked to metastatic potential in liver cancer cell lines.
Shanshan Wang, Jiarui Xie, +15 authors, Liang Wu.
iScience, 2022 Feb 25; 25(3). PMID: 35198910    Free PMC article.
The Bright and the Dark Side of TGF-β Signaling in Hepatocellular Carcinoma: Mechanisms, Dysregulation, and Therapeutic Implications.
Medine Zeynep Gungor, Merve Uysal, Serif Senturk.
Cancers (Basel), 2022 Feb 26; 14(4). PMID: 35205692    Free PMC article.
Review.
Identification and validation a costimulatory molecule gene signature to predict the prognosis and immunotherapy response for hepatocellular carcinoma.
Yinan Hu, Jingyi Liu, +7 authors, Ying Han.
Cancer Cell Int, 2022 Feb 24; 22(1). PMID: 35193632    Free PMC article.
Single-cell gene fusion detection by scFusion.
Zijie Jin, Wenjian Huang, +5 authors, Ruibin Xi.
Nat Commun, 2022 Mar 02; 13(1). PMID: 35228538    Free PMC article.
Single-cell Long Non-coding RNA Landscape of T Cells in Human Cancer Immunity.
Haitao Luo, Dechao Bu, +9 authors, Furong Li.
Genomics Proteomics Bioinformatics, 2021 Jul 21; 19(3). PMID: 34284134    Free PMC article.
A Novel Prognostic Biomarker LPAR6 in Hepatocellular Carcinoma via Associating with Immune Infiltrates.
Jian He, Mei Meng, Hui Wang.
J Clin Transl Hepatol, 2022 Mar 03; 10(1). PMID: 35233377    Free PMC article.
The interaction of CD4+ helper T cells with dendritic cells shapes the tumor microenvironment and immune checkpoint blockade response.
Merav Cohen, Amir Giladi, +16 authors, Ido Amit.
Nat Cancer, 2022 Mar 05; 3(3). PMID: 35241835
Single-cell transcriptomics analysis reveals intratumoral heterogeneity and identifies a gene signature associated with prognosis of hepatocellular carcinoma.
Jialu Liang, Wenhui Chen, +2 authors, Wenlong Zhai.
Biosci Rep, 2022 Feb 17; 42(2). PMID: 35169832    Free PMC article.
Identification of an IDO1-based immune classifier for survival prediction of upper tract urothelial carcinoma.
Wenlong Zhong, Meng Yang, +13 authors, Tianxin Lin.
Cancer Sci, 2021 Dec 29; 113(3). PMID: 34962030    Free PMC article.
Improving Cancer Immunotherapy: Exploring and Targeting Metabolism in Hypoxia Microenvironment.
Jinfen Wei, Meiling Hu, Hongli Du.
Front Immunol, 2022 Mar 15; 13. PMID: 35281061    Free PMC article.
Review.
Determining the Prognostic Value of Spliceosome-Related Genes in Hepatocellular Carcinoma Patients.
Jun Liu, Liming Gu, Dangui Zhang, Wenli Li.
Front Mol Biosci, 2022 Mar 15; 9. PMID: 35281269    Free PMC article.
Trajectory of immune evasion and cancer progression in hepatocellular carcinoma.
Phuong H D Nguyen, Martin Wasser, +33 authors, Valerie Chew.
Nat Commun, 2022 Mar 19; 13(1). PMID: 35301339    Free PMC article.
Novel Perspectives in Immune Checkpoint Inhibitors and the Management of Non-Alcoholic Steatohepatitis-Related Hepatocellular Carcinoma.
Landon L Chan, Stephen L Chan.
Cancers (Basel), 2022 Mar 26; 14(6). PMID: 35326677    Free PMC article.
Review.
Single-Cell RNA Sequencing with Spatial Transcriptomics of Cancer Tissues.
Rashid Ahmed, Tariq Zaman, +4 authors, Anwarul Hasan.
Int J Mol Sci, 2022 Mar 26; 23(6). PMID: 35328458    Free PMC article.
Review.
Cell Differentiation Trajectory in Liver Cirrhosis Predicts Hepatocellular Carcinoma Prognosis and Reveals Potential Biomarkers for Progression of Liver Cirrhosis to Hepatocellular Carcinoma.
Zhaobin He, Cheng Peng, Tianen Li, Jie Li.
Front Genet, 2022 Apr 02; 13. PMID: 35360852    Free PMC article.
Characteristics and Clinical Significance of T-Cell Receptor Repertoire in Hepatocellular Carcinoma.
Zifei Wang, Yu Zhong, +10 authors, Yunfan Sun.
Front Immunol, 2022 Apr 05; 13. PMID: 35371059    Free PMC article.
Tumor-derived exosomes in hypoxic microenvironment: release mechanism, biological function and clinical application.
Da Qian, Yaoyao Xie, Mingyao Huang, Jianfeng Gu.
J Cancer, 2022 Apr 05; 13(5). PMID: 35371323    Free PMC article.
Review.
Reprogramming and redifferentiation of mucosal-associated invariant T cells reveal tumor inhibitory activity.
Chie Sugimoto, Yukie Murakami, +2 authors, Hiroshi Wakao.
Elife, 2022 Apr 06; 11. PMID: 35379387    Free PMC article.
Adaptive antitumor immune response stimulated by bio-nanoparticle based vaccine and checkpoint blockade.
Xuewei Bai, Yanmei Zhou, +11 authors, Jack R Wands.
J Exp Clin Cancer Res, 2022 Apr 09; 41(1). PMID: 35392977    Free PMC article.
Analysis of the Heterogeneity of the Tumor Microenvironment and the Prognosis and Immunotherapy Response of Different Immune Subtypes in Hepatocellular Carcinoma.
Jian Hu, Feifei Mao, +10 authors, Xiaoqin Wang.
J Oncol, 2022 Apr 12; 2022. PMID: 35401750    Free PMC article.
A Novel Gene Signature Based on CDC20 and FCN3 for Prediction of Prognosis and Immune Features in Patients with Hepatocellular Carcinoma.
Xing Lai, Ya-Kun Wu, +6 authors, Hua-Guo Feng.
J Immunol Res, 2022 Apr 12; 2022. PMID: 35402624    Free PMC article.
Hepatocellular carcinoma-infiltrating γδ T cells are functionally defected and allogenic Vδ2+ γδ T cell can be a promising complement.
Wenjing He, Yi Hu, +10 authors, Yangzhe Wu.
Clin Transl Med, 2022 Apr 08; 12(4). PMID: 35390227    Free PMC article.
Next-generation computational tools for interrogating cancer immunity.
Francesca Finotello, Dietmar Rieder, Hubert Hackl, Zlatko Trajanoski.
Nat Rev Genet, 2019 Sep 14; 20(12). PMID: 31515541
Review.
Temporal single-cell tracing reveals clonal revival and expansion of precursor exhausted T cells during anti-PD-1 therapy in lung cancer.
Baolin Liu, Xueda Hu, +8 authors, Zemin Zhang.
Nat Cancer, 2022 Feb 06; 3(1). PMID: 35121991
Programme of self-reactive innate-like T cell-mediated cancer immunity.
Chun Chou, Xian Zhang, +22 authors, Ming O Li.
Nature, 2022 Apr 22; 605(7908). PMID: 35444279
Single-Cell Sequencing Identifies the Heterogeneity of CD8+ T Cells and Novel Biomarker Genes in Hepatocellular Carcinoma.
Hailei Wang, Yang Fu, Bin-Bin Da, Geng Xiong.
J Healthc Eng, 2022 Apr 23; 2022. PMID: 35449866    Free PMC article.
An immune subtype-related prognostic signature of hepatocellular carcinoma based on single-cell sequencing analysis.
Jiaheng Xie, Liang Chen, +7 authors, Ming Wang.
Aging (Albany NY), 2022 Apr 13; 14(7). PMID: 35413690    Free PMC article.
Different subpopulations of regulatory T cells in human autoimmune disease, transplantation, and tumor immunity.
Zhongyi Jiang, Haitao Zhu, +4 authors, Futian Du.
MedComm (2020), 2022 Apr 28; 3(2). PMID: 35474948    Free PMC article.
Review.
Molecular pathogenesis and systemic therapies for hepatocellular carcinoma.
Josep M Llovet, Roser Pinyol, +5 authors, Augusto Villanueva.
Nat Cancer, 2022 Apr 29; 3(4). PMID: 35484418    Free PMC article.
Review.
Pregnancy and Tumour: The Parallels and Differences in Regulatory T Cells.
Prerana Muralidhara, Vanshika Sood, Vishnu Vinayak Ashok, Kushagra Bansal.
Front Immunol, 2022 May 03; 13. PMID: 35493450    Free PMC article.
Review.
High-throughput single-сell sequencing in cancer research.
Qingzhu Jia, Han Chu, +2 authors, Bo Zhu.
Signal Transduct Target Ther, 2022 May 04; 7(1). PMID: 35504878    Free PMC article.
Review.
DIALOGUE maps multicellular programs in tissue from single-cell or spatial transcriptomics data.
Livnat Jerby-Arnon, Aviv Regev.
Nat Biotechnol, 2022 May 06;. PMID: 35513526
Single-cell characterization of malignant phenotypes and microenvironment alteration in retinoblastoma.
Cheng Wu, Jiaqi Yang, +7 authors, Zhi Xie.
Cell Death Dis, 2022 May 07; 13(5). PMID: 35523772    Free PMC article.
Decaprenyl Diphosphate Synthase Subunit 1 (PDSS1): A Potential Prognostic Biomarker and Immunotherapy-Target for Hepatocellular Carcinoma.
Yuping Yang, Jinying Li, +2 authors, Wei Huang.
Cancer Manag Res, 2022 May 11; 14. PMID: 35535267    Free PMC article.
Tumor heterogeneity reshapes the tumor microenvironment to influence drug resistance.
Aiping Zhang, Kai Miao, Heng Sun, Chu-Xia Deng.
Int J Biol Sci, 2022 May 12; 18(7). PMID: 35541919    Free PMC article.
Review.
Single-cell landscape of immunocytes in patients with extrahepatic cholangiocarcinoma.
Lei Xu, Yun Lu, +5 authors, Jianming Wang.
J Transl Med, 2022 May 14; 20(1). PMID: 35562760    Free PMC article.
Dissecting Intra-Tumoral Changes Following Immune Checkpoint Blockades in Intrahepatic Cholangiocarcinoma via Single-Cell Analysis.
Bao-Ye Sun, Cheng Zhou, +8 authors, Shuang-Jian Qiu.
Front Immunol, 2022 May 14; 13. PMID: 35558087    Free PMC article.
The Era of Cytotoxic CD4 T Cells.
Mara Cenerenti, Margaux Saillard, Pedro Romero, Camilla Jandus.
Front Immunol, 2022 May 17; 13. PMID: 35572552    Free PMC article.
Review.
Single-Cell Sequencing and Its Applications in Liver Cancer.
Binle Tian, Qi Li.
Front Oncol, 2022 May 17; 12. PMID: 35574365    Free PMC article.
Review.
Emerging immunotherapy for HCC: A guide for hepatologists.
Friedrich Foerster, Simon Johannes Gairing, Sumera Irie Ilyas, Peter Robert Galle.
Hepatology, 2022 Mar 08; 75(6). PMID: 35253934    Free PMC article.
Review.
An activation to memory differentiation trajectory of tumor-infiltrating lymphocytes informs metastatic melanoma outcomes.
Abhinav Jaiswal, Akanksha Verma, +17 authors, Niroshana Anandasabapathy.
Cancer Cell, 2022 May 11; 40(5). PMID: 35537413    Free PMC article.
Artificial intelligence for the prevention and clinical management of hepatocellular carcinoma.
Julien Calderaro, Tobias Paul Seraphin, Tom Luedde, Tracey G Simon.
J Hepatol, 2022 May 20; 76(6). PMID: 35589255    Free PMC article.
Review.
Distribution, phenotype, functional and clinical relevance of CD8+CD103+ tissue-resident memory T cells in human gastric cancer.
Yang Shen, Xiao-Long Li, +11 authors, Liu-Sheng Peng.
Cancer Immunol Immunother, 2021 Nov 13; 71(7). PMID: 34767045
Identification of a novel prognostic signature for HCC and analysis of costimulatory molecule-related lncRNA AC099850.3.
Qi Wang, Qiong Fang, +2 authors, Meimei Liu.
Sci Rep, 2022 Jun 16; 12(1). PMID: 35705628