Chemotherapy and tumor microenvironment of pancreatic cancer

Qiaofei Liu ¹, Quan Liao ¹, Yupei Zhao ¹

Affiliations

¹ Department of General Surgery, Peking Union Medical College Hospital, Peking Union Medical College & Chinese Academy of Medical Sciences, 1# Shuai Fu Yuan, Dong Dan District, Beijing, 100730 China.

PMID: 28694739
216 References
41 citations

Abstract

Pancreatic cancer is an extremely dismal malignance. Chemotherapy has been widely applied to treat this intractable tumor. It has exclusive tumor microenvironment (TME), characterized by dense desmoplasia and profound infiltrations of immunosuppressive cells. Interactions between stromal cells and cancer cells play vital roles to affect the biological behaviors of pancreatic cancer. Targeting the stromal components of pancreatic cancer has shown promising results. In addition to the direct toxic effects of chemotherapeutic drugs on cancer cells, they can also remodel the TME, eventually affecting their efficacy. Herein, we reviewed the following four aspects; (1) clinical landmark advances of chemotherapy in pancreatic cancer, since 2000; (2) interactions and mechanisms between stromal cells and pancreatic cancer cells; (3) remodeling effects and mechanisms of chemotherapy on TME; (4) targeting stromal components in pancreatic cancer.

Keywords: Cancer associated fibroblasts; Chemotherapy; Myeloid derived suppressor cells; Pancreatic cancer; Pancreatic stellate cells; Tumor associated macrophages; Tumor microenvironment.

Other Links

Free PMC article
Full text on Cancer cell international

References
Cited By

References
Pancreatic cancer stroma: friend or foe? Jesse Gore, Murray Korc. Cancer Cell, 2014 Jun 18; 25(6). PMID: 24937454 Free PMC article. Highly Cited.
Altered recognition of antigen is a mechanism of CD8+ T cell tolerance in cancer. Srinivas Nagaraj, Kapil Gupta, +6 authors, Dmitry I Gabrilovich. less Nat Med, 2007 Jul 03; 13(7). PMID: 17603493 Free PMC article. Highly Cited.
Pancreatic stellate cells enhance stem cell-like phenotypes in pancreatic cancer cells. Shin Hamada, Atsushi Masamune, +7 authors, Tooru Shimosegawa. less Biochem Biophys Res Commun, 2012 Apr 19; 421(2). PMID: 22510406
Anti-CTLA-4 antibodies of IgG2a isotype enhance antitumor activity through reduction of intratumoral regulatory T cells. Mark J Selby, John J Engelhardt, +4 authors, Alan J Korman. less Cancer Immunol Res, 2014 Apr 30; 1(1). PMID: 24777248 Highly Cited.
IL-12 rapidly alters the functional profile of tumor-associated and tumor-infiltrating macrophages in vitro and in vivo. Stephanie K Watkins, Nejat K Egilmez, Jill Suttles, Robert D Stout. J Immunol, 2007 Jan 24; 178(3). PMID: 17237382
Microenvironmental regulation of tumor progression and metastasis. Daniela F Quail, Johanna A Joyce. Nat Med, 2013 Nov 10; 19(11). PMID: 24202395 Free PMC article. Highly Cited. Review.
Arginase II expressed in cancer-associated fibroblasts indicates tissue hypoxia and predicts poor outcome in patients with pancreatic cancer. Yoshinori Ino, Rie Yamazaki-Itoh, +5 authors, Nobuyoshi Hiraoka. less PLoS One, 2013 Feb 21; 8(2). PMID: 23424623 Free PMC article.
Key players in pancreatic cancer-stroma interaction: Cancer-associated fibroblasts, endothelial and inflammatory cells. Michael Friberg Bruun Nielsen, Michael Bau Mortensen, Sönke Detlefsen. World J Gastroenterol, 2016 Mar 15; 22(9). PMID: 26973408 Free PMC article. Highly Cited. Review.
Chemotherapy-triggered cathepsin B release in myeloid-derived suppressor cells activates the Nlrp3 inflammasome and promotes tumor growth. Mélanie Bruchard, Grégoire Mignot, +12 authors, François Ghiringhelli. less Nat Med, 2012 Dec 04; 19(1). PMID: 23202296 Highly Cited.
CC chemokine ligand 2 (CCL2) promotes prostate cancer tumorigenesis and metastasis. Jian Zhang, Lalit Patel, Kenneth J Pienta. Cytokine Growth Factor Rev, 2009 Dec 17; 21(1). PMID: 20005149 Free PMC article. Highly Cited. Review.
The terminology issue for myeloid-derived suppressor cells. Dmitry I Gabrilovich, Vincenzo Bronte, +4 authors, Hans Schreiber. less Cancer Res, 2007 Jan 11; 67(1). PMID: 17210725 Free PMC article. Highly Cited.
Sensitizing protective tumor microenvironments to antibody-mediated therapy. Christian P Pallasch, Ilya Leskov, +15 authors, Michael T Hemann. less Cell, 2014 Feb 04; 156(3). PMID: 24485462 Free PMC article.
Adjuvant chemotherapy with gemcitabine vs observation in patients undergoing curative-intent resection of pancreatic cancer: a randomized controlled trial. Helmut Oettle, Stefan Post, +17 authors, Hanno Riess. less JAMA, 2007 Jan 18; 297(3). PMID: 17227978 Highly Cited.
Macrophage plasticity and interaction with lymphocyte subsets: cancer as a paradigm. Subhra K Biswas, Alberto Mantovani. Nat Immunol, 2010 Sep 22; 11(10). PMID: 20856220 Highly Cited. Review.
Carcinoma-associated fibroblasts: non-neoplastic tumour-promoting mesenchymal cells. Urszula M Polanska, Akira Orimo. J Cell Physiol, 2013 Mar 06; 228(8). PMID: 23460038 Highly Cited. Review.
Atorvastatin (Lipitor) attenuates the effects of aspirin on pancreatic cancerogenesis and the chemotherapeutic efficacy of gemcitabine on pancreatic cancer by promoting M2 polarized tumor associated macrophages. Qiaofei Liu, Yuan Li, +6 authors, Yupei Zhao. less J Exp Clin Cancer Res, 2016 Feb 18; 35. PMID: 26879926 Free PMC article.
Cancer-associated fibroblasts promote M2 polarization of macrophages in pancreatic ductal adenocarcinoma. Aibin Zhang, Yigang Qian, +5 authors, Shusen Zheng. less Cancer Med, 2017 Jan 18; 6(2). PMID: 28097809 Free PMC article.
M2-polarized tumor-associated macrophages promoted epithelial-mesenchymal transition in pancreatic cancer cells, partially through TLR4/IL-10 signaling pathway. Chao-Ying Liu, Juan-Ying Xu, +4 authors, Jun-Li Ding. less Lab Invest, 2013 Jun 12; 93(7). PMID: 23752129 Highly Cited.
Pharmacological macrophage inhibition decreases metastasis formation in a genetic model of pancreatic cancer. Heidi Griesmann, Christof Drexel, +4 authors, Patrick Michl. less Gut, 2016 Mar 26; 66(7). PMID: 27013602
Fate mapping reveals origins and dynamics of monocytes and tissue macrophages under homeostasis. Simon Yona, Ki-Wook Kim, +12 authors, Steffen Jung. less Immunity, 2013 Jan 01; 38(1). PMID: 23273845 Free PMC article. Highly Cited.
Elevated myeloid-derived suppressor cells in pancreatic, esophageal and gastric cancer are an independent prognostic factor and are associated with significant elevation of the Th2 cytokine interleukin-13. Rachel F Gabitass, Nicola E Annels, +2 authors, Deborah D Stocken, Hardev A Pandha, Gary W Middleton. less Cancer Immunol Immunother, 2011 Jun 07; 60(10). PMID: 21644036 Free PMC article. Highly Cited.
Pancreatic Fibroblasts Stimulate the Motility of Pancreatic Cancer Cells through IGF1/IGF1R Signaling under Hypoxia. Toshiki Hirakawa, Masakazu Yashiro, +7 authors, Kosei Hirakawa. less PLoS One, 2016 Aug 04; 11(8). PMID: 27487118 Free PMC article.
Macrophages and therapeutic resistance in cancer. Brian Ruffell, Lisa M Coussens. Cancer Cell, 2015 Apr 11; 27(4). PMID: 25858805 Free PMC article. Highly Cited. Review.
Dynamics of the immune reaction to pancreatic cancer from inception to invasion. Carolyn E Clark, Sunil R Hingorani, +3 authors, Robert H Vonderheide. less Cancer Res, 2007 Oct 03; 67(19). PMID: 17909062 Highly Cited.
A positive feedback loop between mesenchymal-like cancer cells and macrophages is essential to breast cancer metastasis. Shicheng Su, Qiang Liu, +14 authors, Erwei Song. less Cancer Cell, 2014 May 16; 25(5). PMID: 24823638 Highly Cited.
Myeloid-derived suppressor cells in the tumor microenvironment: expect the unexpected. Douglas Marvel, Dmitry I Gabrilovich. J Clin Invest, 2015 Jul 15; 125(9). PMID: 26168215 Free PMC article. Highly Cited. Review.
High intratumoral expression of fibroblast activation protein (FAP) in colon cancer is associated with poorer patient prognosis. Maria L Wikberg, Sofia Edin, +6 authors, Richard Palmqvist. less Tumour Biol, 2013 Jan 19; 34(2). PMID: 23328994 Free PMC article.
The stromal compartments in pancreatic cancer: are there any therapeutic targets? Serena Lunardi, Ruth J Muschel, Thomas B Brunner. Cancer Lett, 2013 Oct 22; 343(2). PMID: 24141189 Highly Cited. Review.
Myeloid-derived Suppressor Cells Recruit CD4(+)/Foxp3(+) Regulatory T Cells in a Murine Cardiac Allograft. T Nakamura, T Nakao, E Ashihara, N Yoshimura. Transplant Proc, 2016 Jun 21; 48(4). PMID: 27320602
Tumor-associated macrophages: functional diversity, clinical significance, and open questions. Subhra K Biswas, Paola Allavena, Alberto Mantovani. Semin Immunopathol, 2013 May 10; 35(5). PMID: 23657835 Highly Cited. Review.
Podoplanin expression by cancer associated fibroblasts predicts poor prognosis of lung adenocarcinoma. Akikazu Kawase, Genichiro Ishii, +8 authors, Atsushi Ochiai. less Int J Cancer, 2008 Jun 12; 123(5). PMID: 18546264
The therapeutic effect of anti-HER2/neu antibody depends on both innate and adaptive immunity. SaeGwang Park, Zhujun Jiang, +11 authors, Yang-Xin Fu. less Cancer Cell, 2010 Aug 17; 18(2). PMID: 20708157 Free PMC article. Highly Cited.
Tumor-promoting phenotype of CD90hi prostate cancer-associated fibroblasts. Hongjuan Zhao, Donna M Peehl. Prostate, 2009 Mar 10; 69(9). PMID: 19267366 Free PMC article.
Myeloid-derived suppressor cell heterogeneity in human cancers. Samantha Solito, Ilaria Marigo, +3 authors, Vincenzo Bronte. less Ann N Y Acad Sci, 2014 Jun 27; 1319. PMID: 24965257 Highly Cited. Review.
Soluble factors from stellate cells induce pancreatic cancer cell proliferation via Nrf2-activated metabolic reprogramming and ROS detoxification. Yuan Seng Wu, Chung Yeng Looi, +2 authors, Ivy Chung. less Oncotarget, 2016 May 12; 7(24). PMID: 27167341 Free PMC article.
Exosomes Derived From Pancreatic Stellate Cells: MicroRNA Signature and Effects on Pancreatic Cancer Cells. Tetsuya Takikawa, Atsushi Masamune, +3 authors, Tooru Shimosegawa. less Pancreas, 2016 Nov 15; 46(1). PMID: 27841793
Lack of host SPARC enhances vascular function and tumor spread in an orthotopic murine model of pancreatic carcinoma. Shanna A Arnold, Lee B Rivera, +8 authors, Rolf A Brekken. less Dis Model Mech, 2009 Dec 17; 3(1-2). PMID: 20007485 Free PMC article.
Enzymatic targeting of the stroma ablates physical barriers to treatment of pancreatic ductal adenocarcinoma. Paolo P Provenzano, Carlos Cuevas, +3 authors, Sunil R Hingorani. less Cancer Cell, 2012 Mar 24; 21(3). PMID: 22439937 Free PMC article. Highly Cited.
FOLFIRINOX versus gemcitabine for metastatic pancreatic cancer. Thierry Conroy, Françoise Desseigne, +19 authors, PRODIGE Intergroup. less N Engl J Med, 2011 May 13; 364(19). PMID: 21561347 Highly Cited.
Pancreatic stellate cells form a niche for cancer stem cells and promote their self-renewal and invasiveness. Enza Lonardo, Javier Frias-Aldeguer, Patrick C Hermann, Christopher Heeschen. Cell Cycle, 2012 Mar 17; 11(7). PMID: 22421149 Highly Cited.
HMGB1 enhances the protumoral activities of M2 macrophages by a RAGE-dependent mechanism. Armando Rojas, Fernando Delgado-López, +7 authors, Jorge Llanos. less Tumour Biol, 2015 Oct 07; 37(3). PMID: 26440051
Radiological and surgical implications of neoadjuvant treatment with FOLFIRINOX for locally advanced and borderline resectable pancreatic cancer. Cristina R Ferrone, Giovanni Marchegiani, +18 authors, Carlos Fernández-del Castillo. less Ann Surg, 2015 Jan 20; 261(1). PMID: 25599322 Free PMC article. Highly Cited.
Comparison of adjuvant gemcitabine and capecitabine with gemcitabine monotherapy in patients with resected pancreatic cancer (ESPAC-4): a multicentre, open-label, randomised, phase 3 trial. John P Neoptolemos, Daniel H Palmer, +32 authors, European Study Group for Pancreatic Cancer. less Lancet, 2017 Jan 29; 389(10073). PMID: 28129987 Highly Cited.
Functional polarization of tumour-associated macrophages by tumour-derived lactic acid. Oscar R Colegio, Ngoc-Quynh Chu, +10 authors, Ruslan Medzhitov. less Nature, 2014 Jul 22; 513(7519). PMID: 25043024 Free PMC article. Highly Cited.
Chemotherapy-Derived Inflammatory Responses Accelerate the Formation of Immunosuppressive Myeloid Cells in the Tissue Microenvironment of Human Pancreatic Cancer. Shintaro Takeuchi, Muhammad Baghdadi, +13 authors, Satoshi Hirano. less Cancer Res, 2015 May 09; 75(13). PMID: 25952647
CSF1/CSF1R blockade reprograms tumor-infiltrating macrophages and improves response to T-cell checkpoint immunotherapy in pancreatic cancer models. Yu Zhu, Brett L Knolhoff, +7 authors, David G DeNardo. less Cancer Res, 2014 Aug 02; 74(18). PMID: 25082815 Free PMC article. Highly Cited.
Adjuvant chemoradiotherapy and chemotherapy in resectable pancreatic cancer: a randomised controlled trial. J P Neoptolemos, J A Dunn, +15 authors, European Study Group for Pancreatic Cancer. less Lancet, 2001 Nov 22; 358(9293). PMID: 11716884 Highly Cited.
History of myeloid-derived suppressor cells. James E Talmadge, Dmitry I Gabrilovich. Nat Rev Cancer, 2013 Sep 26; 13(10). PMID: 24060865 Free PMC article. Highly Cited. Review.
Pancreatic adenocarcinoma up-regulated factor (PAUF) enhances the accumulation and functional activity of myeloid-derived suppressor cells (MDSCs) in pancreatic cancer. Jinhoi Song, Jaemin Lee, +15 authors, Seokho Kim. less Oncotarget, 2016 Jun 21; 7(32). PMID: 27322081 Free PMC article.
Reg3β deficiency impairs pancreatic tumor growth by skewing macrophage polarization. Meritxell Gironella, Carlos Calvo, +4 authors, Emma Folch-Puy. less Cancer Res, 2013 Jul 23; 73(18). PMID: 23867474
Postsurgical adjuvant tumor therapy by combining anti-angiopoietin-2 and metronomic chemotherapy limits metastatic growth. Kshitij Srivastava, Junhao Hu, +8 authors, Hellmut G Augustin. less Cancer Cell, 2014 Dec 10; 26(6). PMID: 25490450
Fibrogenesis in pancreatic cancer is a dynamic process regulated by macrophage-stellate cell interaction. Chanjuan Shi, M Kay Washington, +11 authors, Anna L Means. less Lab Invest, 2014 Feb 19; 94(4). PMID: 24535260 Free PMC article.
Neoadjuvant chemoradiation therapy with gemcitabine/cisplatin and surgery versus immediate surgery in resectable pancreatic cancer: results of the first prospective randomized phase II trial. Henriette Golcher, Thomas B Brunner, +10 authors, Werner Hohenberger. less Strahlenther Onkol, 2014 Sep 26; 191(1). PMID: 25252602 Free PMC article. Highly Cited.
Myeloid-Derived Suppressor Cells Are Controlled by Regulatory T Cells via TGF-β during Murine Colitis. Cho-Rong Lee, Yewon Kwak, +9 authors, Sung-Gyoo Park. less Cell Rep, 2016 Dec 24; 17(12). PMID: 28009291
Vascular endothelial growth factor-induced skin carcinogenesis depends on recruitment and alternative activation of macrophages. Nina Linde, Wiltrud Lederle, +3 authors, Margareta M Mueller. less J Pathol, 2012 Jan 21; 227(1). PMID: 22262122
Increased survival in pancreatic cancer with nab-paclitaxel plus gemcitabine. Daniel D Von Hoff, Thomas Ervin, +20 authors, Markus F Renschler. less N Engl J Med, 2013 Oct 18; 369(18). PMID: 24131140 Free PMC article. Highly Cited.
Imaging tumor-stroma interactions during chemotherapy reveals contributions of the microenvironment to resistance. Elizabeth S Nakasone, Hanne A Askautrud, +13 authors, Mikala Egeblad. less Cancer Cell, 2012 Apr 21; 21(4). PMID: 22516258 Free PMC article. Highly Cited.
Tumor-derived granulocyte-macrophage colony-stimulating factor regulates myeloid inflammation and T cell immunity in pancreatic cancer. Lauren J Bayne, Gregory L Beatty, +4 authors, Robert H Vonderheide. less Cancer Cell, 2012 Jun 16; 21(6). PMID: 22698406 Free PMC article. Highly Cited.
Retinoic acid-induced pancreatic stellate cell quiescence reduces paracrine Wnt-β-catenin signaling to slow tumor progression. Fieke E M Froeling, Christine Feig, +6 authors, Hemant M Kocher. less Gastroenterology, 2011 Jun 28; 141(4). PMID: 21704588 Highly Cited.
Preoperative/neoadjuvant therapy in pancreatic cancer: a systematic review and meta-analysis of response and resection percentages. Sonja Gillen, Tibor Schuster, +2 authors, Jörg Kleeff. less PLoS Med, 2010 Apr 28; 7(4). PMID: 20422030 Free PMC article. Highly Cited. Systematic Review.
Pancreatic stellate cells promote epithelial-mesenchymal transition in pancreatic cancer cells. Kazuhiro Kikuta, Atsushi Masamune, +7 authors, Tooru Shimosegawa. less Biochem Biophys Res Commun, 2010 Nov 18; 403(3-4). PMID: 21081113
Stromal elements act to restrain, rather than support, pancreatic ductal adenocarcinoma. Andrew D Rhim, Paul E Oberstein, +14 authors, Ben Z Stanger. less Cancer Cell, 2014 May 27; 25(6). PMID: 24856585 Free PMC article. Highly Cited.
Antibody therapeutics in cancer. Mark X Sliwkowski, Ira Mellman. Science, 2013 Sep 14; 341(6151). PMID: 24031011 Highly Cited. Review.
Macrophages and cathepsin proteases blunt chemotherapeutic response in breast cancer. Tanaya Shree, Oakley C Olson, +7 authors, Johanna A Joyce. less Genes Dev, 2011 Dec 14; 25(23). PMID: 22156207 Free PMC article. Highly Cited.
Pancreatic cancer-associated stellate cells promote differentiation of myeloid-derived suppressor cells in a STAT3-dependent manner. Thomas A Mace, Zeenath Ameen, +9 authors, Gregory B Lesinski. less Cancer Res, 2013 Mar 22; 73(10). PMID: 23514705 Free PMC article. Highly Cited.
Hyaluronan impairs vascular function and drug delivery in a mouse model of pancreatic cancer. Michael A Jacobetz, Derek S Chan, +17 authors, David A Tuveson. less Gut, 2012 Apr 03; 62(1). PMID: 22466618 Free PMC article. Highly Cited.
Tissue-specific signals control reversible program of localization and functional polarization of macrophages. Yasutaka Okabe, Ruslan Medzhitov. Cell, 2014 May 06; 157(4). PMID: 24792964 Free PMC article. Highly Cited.
Hypoxic stellate cells of pancreatic cancer stroma regulate extracellular matrix fiber organization and cancer cell motility. Masafumi Sada, Kenoki Ohuchida, +7 authors, Masafumi Nakamura. less Cancer Lett, 2016 Jan 26; 372(2). PMID: 26805763
Autophagy Is Required for Activation of Pancreatic Stellate Cells, Associated With Pancreatic Cancer Progression and Promotes Growth of Pancreatic Tumors in Mice. Sho Endo, Kohei Nakata, +18 authors, Masafumi Nakamura. less Gastroenterology, 2017 Jan 28; 152(6). PMID: 28126348 Highly Cited.
Impact by pancreatic stellate cells on epithelial-mesenchymal transition and pancreatic cancer cell invasion: Adding a third dimension in vitro. Emelie Karnevi, Ann H Rosendahl, +2 authors, Roland Andersson. less Exp Cell Res, 2016 Jul 23; 346(2). PMID: 27443257
Transforming Growth Factor-β Limits Secretion of Lumican by Activated Stellate Cells within Primary Pancreatic Adenocarcinoma Tumors. Ya'an Kang, David Roife, +16 authors, Jason B Fleming. less Clin Cancer Res, 2016 Apr 30; 22(19). PMID: 27126993 Free PMC article.
Cancer-Associated Fibroblasts Are Activated in Incipient Neoplasia to Orchestrate Tumor-Promoting Inflammation in an NF-kappaB-Dependent Manner. Neta Erez, Morgan Truitt, +2 authors, Peter Olson, Sarah Tuttleton Arron, Douglas Hanahan. less Cancer Cell, 2010 Feb 09; 17(2). PMID: 20138012 Highly Cited.
Role of pancreatic stellate cells in pancreatic cancer metastasis. Zhihong Xu, Alain Vonlaufen, +8 authors, Minoti V Apte. less Am J Pathol, 2010 Oct 12; 177(5). PMID: 20934972 Free PMC article. Highly Cited.
Mononuclear phagocyte heterogeneity in cancer: different subsets and activation states reaching out at the tumor site. Damya Laoui, Eva Van Overmeire, +7 authors, Jo A Van Ginderachter. less Immunobiology, 2011 Aug 02; 216(11). PMID: 21803441 Review.
Transforming growth factor-beta suppresses nonmetastatic colon cancer through Smad4 and adaptor protein ELF at an early stage of tumorigenesis. Yi Tang, Varalakshmi Katuri, +9 authors, Lopa Mishra. less Cancer Res, 2005 May 19; 65(10). PMID: 15899814
A Phase I Study of FOLFIRINOX Plus IPI-926, a Hedgehog Pathway Inhibitor, for Advanced Pancreatic Adenocarcinoma. Andrew H Ko, Noelle LoConte, +9 authors, Hedy L Kindler. less Pancreas, 2015 Sep 22; 45(3). PMID: 26390428 Free PMC article.
Cancer-associated fibroblast-derived annexin A6+ extracellular vesicles support pancreatic cancer aggressiveness. Julie Leca, Sébastien Martinez, +20 authors, Richard Tomasini. less J Clin Invest, 2016 Nov 02; 126(11). PMID: 27701147 Free PMC article. Highly Cited.
Tumour-associated macrophages influence canine mammary cancer stem-like cells enhancing their pro-angiogenic properties. A Rybicka, C Eyileten, +4 authors, M Krol. less J Physiol Pharmacol, 2016 Oct 26; 67(4). PMID: 27779470
KIT oncogene inhibition drives intratumoral macrophage M2 polarization. Michael J Cavnar, Shan Zeng, +13 authors, Ronald P DeMatteo. less J Exp Med, 2013 Dec 11; 210(13). PMID: 24323358 Free PMC article.
Anti-CD47 antibody synergizes with rituximab to promote phagocytosis and eradicate non-Hodgkin lymphoma. Mark P Chao, Ash A Alizadeh, +17 authors, Ravindra Majeti. less Cell, 2010 Sep 04; 142(5). PMID: 20813259 Free PMC article. Highly Cited.
Vitamin D receptor-mediated stromal reprogramming suppresses pancreatitis and enhances pancreatic cancer therapy. Mara H Sherman, Ruth T Yu, +26 authors, Ronald M Evans. less Cell, 2014 Sep 27; 159(1). PMID: 25259922 Free PMC article. Highly Cited.
CD146 attenuation in cancer-associated fibroblasts promotes pancreatic cancer progression. Biao Zheng, Kenoki Ohuchida, +10 authors, Masao Tanaka. less Mol Carcinog, 2015 Sep 17; 55(11). PMID: 26373617
Leukocyte complexity predicts breast cancer survival and functionally regulates response to chemotherapy. David G DeNardo, Donal J Brennan, +12 authors, Lisa M Coussens. less Cancer Discov, 2011 Nov 01; 1(1). PMID: 22039576 Free PMC article. Highly Cited.
Targeting distinct tumor-infiltrating myeloid cells by inhibiting CSF-1 receptor: combating tumor evasion of antiangiogenic therapy. Saul J Priceman, James L Sung, +8 authors, Lily Wu. less Blood, 2009 Dec 17; 115(7). PMID: 20008303 Free PMC article. Highly Cited.
COX2/mPGES1/PGE2 pathway regulates PD-L1 expression in tumor-associated macrophages and myeloid-derived suppressor cells. Victor Prima, Lyudmila N Kaliberova, +2 authors, Sergey Kaliberov, David T Curiel, Sergei Kusmartsev. less Proc Natl Acad Sci U S A, 2017 Jan 18; 114(5). PMID: 28096371 Free PMC article. Highly Cited.
Anti-IL-6 receptor mAb eliminates myeloid-derived suppressor cells and inhibits tumor growth by enhancing T-cell responses. Kentaro Sumida, Daiko Wakita, +6 authors, Takashi Nishimura. less Eur J Immunol, 2012 Jun 02; 42(8). PMID: 22653638
CD10+ pancreatic stellate cells enhance the progression of pancreatic cancer. Naoki Ikenaga, Kenoki Ohuchida, +7 authors, Masao Tanaka. less Gastroenterology, 2010 Aug 06; 139(3). PMID: 20685603
Myeloid-derived suppressor cells as regulators of the immune system. Dmitry I Gabrilovich, Srinivas Nagaraj. Nat Rev Immunol, 2009 Feb 07; 9(3). PMID: 19197294 Free PMC article. Highly Cited. Review.
Pancreatic stellate cells support tumour metabolism through autophagic alanine secretion. Cristovão M Sousa, Douglas E Biancur, +12 authors, Alec C Kimmelman. less Nature, 2016 Aug 12; 536(7617). PMID: 27509858 Free PMC article. Highly Cited.
Expansion of myeloid immune suppressor Gr+CD11b+ cells in tumor-bearing host directly promotes tumor angiogenesis. Li Yang, Laura M DeBusk, +6 authors, P Charles Lin. less Cancer Cell, 2004 Oct 19; 6(4). PMID: 15488763 Highly Cited.
Radiation Therapy Induces Macrophages to Suppress T-Cell Responses Against Pancreatic Tumors in Mice. Lena Seifert, Gregor Werba, +16 authors, George Miller. less Gastroenterology, 2016 Mar 08; 150(7). PMID: 26946344 Free PMC article. Highly Cited.
Evaluation of innate and adaptive immunity contributing to the antitumor effects of PD1 blockade in an orthotopic murine model of pancreatic cancer. Marcela D'Alincourt Salazar, Edwin R Manuel, +4 authors, Don J Diamond. less Oncoimmunology, 2016 Jul 30; 5(6). PMID: 27471630 Free PMC article.
CXCL12 chemokine expression suppresses human pancreatic cancer growth and metastasis. Ishan Roy, Noah P Zimmerman, +3 authors, Michael B Dwinell. less PLoS One, 2014 Mar 07; 9(3). PMID: 24594697 Free PMC article.
Identification of discrete tumor-induced myeloid-derived suppressor cell subpopulations with distinct T cell-suppressive activity. Kiavash Movahedi, Martin Guilliams, +5 authors, Jo A Van Ginderachter. less Blood, 2008 Feb 15; 111(8). PMID: 18272812 Highly Cited.
FAP-overexpressing fibroblasts produce an extracellular matrix that enhances invasive velocity and directionality of pancreatic cancer cells. Hyung-Ok Lee, Stefanie R Mullins, +3 authors, Jonathan D Cheng. less BMC Cancer, 2011 Jun 15; 11. PMID: 21668992 Free PMC article. Highly Cited.
Stromal biology and therapy in pancreatic cancer: a changing paradigm. Albrecht Neesse, Hana Algül, David A Tuveson, Thomas M Gress. Gut, 2015 May 23; 64(9). PMID: 25994217 Highly Cited. Review.
Macrophage biology in development, homeostasis and disease. Thomas A Wynn, Ajay Chawla, Jeffrey W Pollard. Nature, 2013 Apr 27; 496(7446). PMID: 23619691 Free PMC article. Highly Cited. Review.
Pharmacological targeting of the protein synthesis mTOR/4E-BP1 pathway in cancer-associated fibroblasts abrogates pancreatic tumour chemoresistance. Camille Duluc, Siham Moatassim-Billah, +13 authors, Corinne Bousquet. less EMBO Mol Med, 2015 Apr 03; 7(6). PMID: 25834145 Free PMC article.
Cancer-Associated Fibroblasts in Pancreatic Cancer Are Reprogrammed by Tumor-Induced Alterations in Genomic DNA Methylation. Qian Xiao, Donger Zhou, +12 authors, Lei Zheng. less Cancer Res, 2016 Aug 09; 76(18). PMID: 27496707 Free PMC article.
CD40 agonists alter tumor stroma and show efficacy against pancreatic carcinoma in mice and humans. Gregory L Beatty, Elena G Chiorean, +10 authors, Robert H Vonderheide. less Science, 2011 Mar 26; 331(6024). PMID: 21436454 Free PMC article. Highly Cited.
Autophagy and cellular immune responses. Yuting Ma, Lorenzo Galluzzi, Laurence Zitvogel, Guido Kroemer. Immunity, 2013 Aug 27; 39(2). PMID: 23973220 Highly Cited. Review.
A novel chemoimmunomodulating property of docetaxel: suppression of myeloid-derived suppressor cells in tumor bearers. Krithika N Kodumudi, Karrune Woan, +3 authors, Julie Y Djeu. less Clin Cancer Res, 2010 Aug 13; 16(18). PMID: 20702612 Free PMC article. Highly Cited.
Activation of fibroblasts in cancer stroma. Kati Räsänen, Antti Vaheri. Exp Cell Res, 2010 May 11; 316(17). PMID: 20451516 Highly Cited. Review.
Second-line oxaliplatin, folinic acid, and fluorouracil versus folinic acid and fluorouracil alone for gemcitabine-refractory pancreatic cancer: outcomes from the CONKO-003 trial. Helmut Oettle, Hanno Riess, +11 authors, Uwe Pelzer. less J Clin Oncol, 2014 Jul 02; 32(23). PMID: 24982456 Highly Cited.
Pancreatic stellate cell: physiologic role, role in fibrosis and cancer. Minote Apte, Romano C Pirola, Jeremy S Wilson. Curr Opin Gastroenterol, 2015 Jul 01; 31(5). PMID: 26125317 Review.
Phosphodiesterase-5 inhibition augments endogenous antitumor immunity by reducing myeloid-derived suppressor cell function. Paolo Serafini, Kristen Meckel, +6 authors, Ivan Borrello. less J Exp Med, 2006 Nov 15; 203(12). PMID: 17101732 Free PMC article. Highly Cited.
Depletion of carcinoma-associated fibroblasts and fibrosis induces immunosuppression and accelerates pancreas cancer with reduced survival. Berna C Özdemir, Tsvetelina Pentcheva-Hoang, +18 authors, Raghu Kalluri. less Cancer Cell, 2014 May 27; 25(6). PMID: 24856586 Free PMC article. Highly Cited.
Colony stimulating factors and myeloid cell biology in health and disease. John A Hamilton, Adrian Achuthan. Trends Immunol, 2012 Sep 25; 34(2). PMID: 23000011 Highly Cited. Review.
IL-6-stimulated CD11b+ CD14+ HLA-DR- myeloid-derived suppressor cells, are associated with progression and poor prognosis in squamous cell carcinoma of the esophagus. Miao-Fen Chen, Feng-Che Kuan, +5 authors, Kuan-Der Lee. less Oncotarget, 2014 Sep 23; 5(18). PMID: 25238263 Free PMC article.
Targeted depletion of an MDSC subset unmasks pancreatic ductal adenocarcinoma to adaptive immunity. Ingunn M Stromnes, J Scott Brockenbrough, +5 authors, Sunil R Hingorani. less Gut, 2014 Feb 22; 63(11). PMID: 24555999 Free PMC article. Highly Cited.
Myeloid-derived suppressor cells contribute to A2B adenosine receptor-induced VEGF production and angiogenesis in a mouse melanoma model. Claudia Sorrentino, Lucio Miele, +2 authors, Amalia Porta, Aldo Pinto, Silvana Morello. less Oncotarget, 2015 Sep 01; 6(29). PMID: 26317647 Free PMC article.
Myxomaviral Anti-Inflammatory Serpin Reduces Myeloid-Derived Suppressor Cells and Human Pancreatic Cancer Cell Growth in Mice. Donghang Zheng, Hao Chen, +5 authors, Alexandra R Lucas. less J Cancer Sci Ther, 2013 Aug 19; 5. PMID: 25798214 Free PMC article.
Contribution of microRNAs in understanding the pancreatic tumor microenvironment involving cancer associated stellate and fibroblast cells. Shadan Ali, Raagini Suresh, +6 authors, Fazlul H Sarkar. less Am J Cancer Res, 2015 Jun 06; 5(3). PMID: 26046003 Free PMC article.
Adjuvant chemotherapy with fluorouracil plus folinic acid vs gemcitabine following pancreatic cancer resection: a randomized controlled trial. John P Neoptolemos, Deborah D Stocken, +25 authors, European Study Group for Pancreatic Cancer. less JAMA, 2010 Sep 09; 304(10). PMID: 20823433 Highly Cited.
Hypoxia promotes glioma-associated macrophage infiltration via periostin and subsequent M2 polarization by upregulating TGF-beta and M-CSFR. Xiaofan Guo, Hao Xue, +11 authors, Gang Li. less Oncotarget, 2016 Sep 08; 7(49). PMID: 27602954 Free PMC article.
G-CSF-initiated myeloid cell mobilization and angiogenesis mediate tumor refractoriness to anti-VEGF therapy in mouse models. Farbod Shojaei, Xiumin Wu, +5 authors, Napoleone Ferrara. less Proc Natl Acad Sci U S A, 2009 Apr 07; 106(16). PMID: 19346489 Free PMC article. Highly Cited.
Bv8 regulates myeloid-cell-dependent tumour angiogenesis. Farbod Shojaei, Xiumin Wu, +13 authors, Napoleone Ferrara. less Nature, 2007 Dec 08; 450(7171). PMID: 18064003 Highly Cited.
Fibroblast activation protein-α-expressing fibroblasts promote the progression of pancreatic ductal adenocarcinoma. Tomoya Kawase, Yumiko Yasui, +8 authors, Keisuke Hino. less BMC Gastroenterol, 2015 Sep 04; 15. PMID: 26330349 Free PMC article.
Subsets of myeloid-derived suppressor cells in tumor-bearing mice. Je-In Youn, Srinivas Nagaraj, Michelle Collazo, Dmitry I Gabrilovich. J Immunol, 2008 Oct 04; 181(8). PMID: 18832739 Free PMC article. Highly Cited.
Tumor-induced tolerance and immune suppression depend on the C/EBPbeta transcription factor. Ilaria Marigo, Erika Bosio, +13 authors, Vincenzo Bronte. less Immunity, 2010 Jul 08; 32(6). PMID: 20605485 Highly Cited.
Kindlin-2 in pancreatic stellate cells promotes the progression of pancreatic cancer. Naoki Yoshida, Atsushi Masamune, +5 authors, Tooru Shimosegawa. less Cancer Lett, 2017 Jan 18; 390. PMID: 28093281
Fate mapping analysis reveals that adult microglia derive from primitive macrophages. Florent Ginhoux, Melanie Greter, +9 authors, Miriam Merad. less Science, 2010 Oct 23; 330(6005). PMID: 20966214 Free PMC article. Highly Cited.
Granulocytic myeloid-derived suppressor cells maintain feto-maternal tolerance by inducing Foxp3 expression in CD4+CD25-T cells by activation of the TGF-β/β-catenin pathway. Xiaomin Kang, Xiaoxin Zhang, +4 authors, Aimin Zhao. less Mol Hum Reprod, 2016 Mar 27; 22(7). PMID: 27016139
Pancreatic stellate cells promote hapto-migration of cancer cells through collagen I-mediated signalling pathway. J Lu, S Zhou, +3 authors, M Siech, H Habisch, T Seufferlein, M G Bachem. less Br J Cancer, 2013 Nov 10; 110(2). PMID: 24201748 Free PMC article.
Pancreatic stellate cells increase the invasion of human pancreatic cancer cells through the stromal cell-derived factor-1/CXCR4 axis. Zhenjun Gao, Xingpeng Wang, +2 authors, Kai Wu, Yan Zhao, Guoyong Hu. less Pancreatology, 2010 May 21; 10(2-3). PMID: 20484957
Immunogenic cell death in cancer therapy. Guido Kroemer, Lorenzo Galluzzi, Oliver Kepp, Laurence Zitvogel. Annu Rev Immunol, 2012 Nov 20; 31. PMID: 23157435 Highly Cited. Review.
Macrophage activation and polarization: nomenclature and experimental guidelines. Peter J Murray, Judith E Allen, +22 authors, Thomas A Wynn. less Immunity, 2014 Jul 19; 41(1). PMID: 25035950 Free PMC article. Highly Cited.
Tumor-induced STAT3 activation in monocytic myeloid-derived suppressor cells enhances stemness and mesenchymal properties in human pancreatic cancer. Roheena Z Panni, Dominic E Sanford, +9 authors, David C Linehan. less Cancer Immunol Immunother, 2014 Mar 22; 63(5). PMID: 24652403 Free PMC article. Highly Cited.
Macrophage delivery of an oncolytic virus abolishes tumor regrowth and metastasis after chemotherapy or irradiation. Munitta Muthana, Samuel Rodrigues, +6 authors, Claire E Lewis. less Cancer Res, 2012 Nov 23; 73(2). PMID: 23172310
Macrophage-secreted granulin supports pancreatic cancer metastasis by inducing liver fibrosis. Sebastian R Nielsen, Valeria Quaranta, +15 authors, Michael C Schmid. less Nat Cell Biol, 2016 Apr 19; 18(5). PMID: 27088855 Free PMC article. Highly Cited.
Pancreatic stellate cells radioprotect pancreatic cancer cells through β1-integrin signaling. Tine S Mantoni, Serena Lunardi, +2 authors, Osama Al-Assar, Atsushi Masamune, Thomas B Brunner. less Cancer Res, 2011 May 12; 71(10). PMID: 21558392 Free PMC article.
Sorafenib perpetuates cellular anticancer effector functions by modulating the crosstalk between macrophages and natural killer cells. Martin Franz Sprinzl, Florian Reisinger, +11 authors, Ulrike Protzer. less Hepatology, 2013 Feb 21; 57(6). PMID: 23424039
Paracrine IL-6 signaling mediates the effects of pancreatic stellate cells on epithelial-mesenchymal transition via Stat3/Nrf2 pathway in pancreatic cancer cells. Yuan Seng Wu, Ivy Chung, +3 authors, Chung Yeng Looi. less Biochim Biophys Acta Gen Subj, 2016 Oct 18; 1861(2). PMID: 27750041
Critical role of Trib1 in differentiation of tissue-resident M2-like macrophages. Takashi Satoh, Hiroyasu Kidoya, +8 authors, Shizuo Akira. less Nature, 2013 Mar 22; 495(7442). PMID: 23515163 Highly Cited.
The cellular and molecular origin of tumor-associated macrophages. Ruth A Franklin, Will Liao, +5 authors, Ming O Li. less Science, 2014 May 09; 344(6186). PMID: 24812208 Free PMC article. Highly Cited.
Adjuvant chemotherapy with gemcitabine and long-term outcomes among patients with resected pancreatic cancer: the CONKO-001 randomized trial. Helmut Oettle, Peter Neuhaus, +10 authors, Hanno Riess. less JAMA, 2013 Oct 10; 310(14). PMID: 24104372 Highly Cited.
IL-4-induced arginase 1 suppresses alloreactive T cells in tumor-bearing mice. Vincenzo Bronte, Paolo Serafini, +9 authors, Paola Zanovello. less J Immunol, 2002 Dec 24; 170(1). PMID: 12496409 Highly Cited.
Epidemiology, risk factors, and the promotion of pancreatic cancer: role of the stellate cell. Stephen Pandol, Anna Gukovskaya, +4 authors, Aurelia Lugea. less J Gastroenterol Hepatol, 2012 Feb 15; 27 Suppl 2. PMID: 22320930 Free PMC article. Review.
Lactic acid polarizes macrophages to a tumor-promoting state. Oscar R Colegio. Oncoimmunology, 2016 May 04; 5(3). PMID: 27141329 Free PMC article.
PF-03732010: a fully human monoclonal antibody against P-cadherin with antitumor and antimetastatic activity. Cathy C Zhang, Zhengming Yan, +15 authors, Todd VanArsdale. less Clin Cancer Res, 2010 Sep 11; 16(21). PMID: 20829331
Macrophages mediate gemcitabine resistance of pancreatic adenocarcinoma by upregulating cytidine deaminase. N Weizman, Y Krelin, +4 authors, Z Gil. less Oncogene, 2013 Sep 03; 33(29). PMID: 23995783 Highly Cited.
The anti-fibrotic agent pirfenidone synergizes with cisplatin in killing tumor cells and cancer-associated fibroblasts. Melanie Mediavilla-Varela, Kingsley Boateng, David Noyes, Scott J Antonia. BMC Cancer, 2016 Mar 05; 16. PMID: 26935219 Free PMC article.
Macrophage scavenger receptor a promotes tumor progression in murine models of ovarian and pancreatic cancer. Claudine Neyen, Annette Plüddemann, +4 authors, Thorsten Hagemann. less J Immunol, 2013 Mar 01; 190(7). PMID: 23447685 Free PMC article.
Podoplanin-expressing cancer-associated fibroblasts inhibit small cell lung cancer growth. Akiko Takahashi, Genichiro Ishii, +13 authors, Atsushi Ochiai. less Oncotarget, 2015 Apr 25; 6(11). PMID: 25909164 Free PMC article.
Hypoxia induces macrophage polarization and re-education toward an M2 phenotype in U87 and U251 glioblastoma models. Marine M Leblond, Aurélie N Gérault, +4 authors, Samuel Valable. less Oncoimmunology, 2016 Mar 05; 5(1). PMID: 26942063 Free PMC article.
Targeting CXCL12 from FAP-expressing carcinoma-associated fibroblasts synergizes with anti-PD-L1 immunotherapy in pancreatic cancer. Christine Feig, James O Jones, +12 authors, Douglas T Fearon. less Proc Natl Acad Sci U S A, 2013 Nov 28; 110(50). PMID: 24277834 Free PMC article. Highly Cited.
Gemcitabine plus bevacizumab compared with gemcitabine plus placebo in patients with advanced pancreatic cancer: phase III trial of the Cancer and Leukemia Group B (CALGB 80303). Hedy Lee Kindler, Donna Niedzwiecki, +12 authors, Richard M Goldberg. less J Clin Oncol, 2010 Jul 08; 28(22). PMID: 20606091 Free PMC article. Highly Cited.
Tumor-associated macrophages regulate murine breast cancer stem cells through a novel paracrine EGFR/Stat3/Sox-2 signaling pathway. Jian Yang, Debbie Liao, +6 authors, Yunping Luo. less Stem Cells, 2012 Nov 22; 31(2). PMID: 23169551 Highly Cited.
Radiation promotes epithelial-to-mesenchymal transition and invasion of pancreatic cancer cell by activating carcinoma-associated fibroblasts. Doudou Li, Chao Qu, +6 authors, Zhiqiang Meng. less Am J Cancer Res, 2016 Nov 09; 6(10). PMID: 27822411 Free PMC article.
Activated pancreatic stellate cells sequester CD8+ T cells to reduce their infiltration of the juxtatumoral compartment of pancreatic ductal adenocarcinoma. Abasi Ene-Obong, Andrew J Clear, +9 authors, Hemant M Kocher. less Gastroenterology, 2013 Jul 31; 145(5). PMID: 23891972 Free PMC article. Highly Cited.
Acinar cell-specific knockout of the PTHrP gene decreases the proinflammatory and profibrotic responses in pancreatitis. Vandanajay Bhatia, Cristiana Rastellini, +3 authors, Miriam Falzon. less Am J Physiol Gastrointest Liver Physiol, 2014 Jul 19; 307(5). PMID: 25035110 Free PMC article.
Chemotherapy alters monocyte differentiation to favor generation of cancer-supporting M2 macrophages in the tumor microenvironment. Eveline M Dijkgraaf, Moniek Heusinkveld, +7 authors, Sjoerd H van der Burg. less Cancer Res, 2013 Feb 26; 73(8). PMID: 23436796 Highly Cited.
Retinoic acid inhibits pancreatic cancer cell migration and EMT through the downregulation of IL-6 in cancer associated fibroblast cells. Jian Guan, Hui Zhang, +7 authors, Jie Chen. less Cancer Lett, 2013 Dec 18; 345(1). PMID: 24334138
Polarization of Monocytic Myeloid-Derived Suppressor Cells by Hepatitis B Surface Antigen Is Mediated via ERK/IL-6/STAT3 Signaling Feedback and Restrains the Activation of T Cells in Chronic Hepatitis B Virus Infection. Zhong Fang, Jin Li, +10 authors, Zhenghong Yuan. less J Immunol, 2015 Sep 30; 195(10). PMID: 26416274
Nanoliposomal irinotecan with fluorouracil and folinic acid in metastatic pancreatic cancer after previous gemcitabine-based therapy (NAPOLI-1): a global, randomised, open-label, phase 3 trial. Andrea Wang-Gillam, Chung-Pin Li, +19 authors, NAPOLI-1 Study Group. less Lancet, 2015 Nov 30; 387(10018). PMID: 26615328 Highly Cited.
Comparison of gemcitabine versus the matrix metalloproteinase inhibitor BAY 12-9566 in patients with advanced or metastatic adenocarcinoma of the pancreas: a phase III trial of the National Cancer Institute of Canada Clinical Trials Group. M J Moore, J Hamm, +12 authors, National Cancer Institute of Canada Clinical Trials Group. less J Clin Oncol, 2003 Aug 30; 21(17). PMID: 12947065
Tumor-targeted interferon-alpha delivery by Tie2-expressing monocytes inhibits tumor growth and metastasis. Michele De Palma, Roberta Mazzieri, +11 authors, Luigi Naldini. less Cancer Cell, 2008 Oct 07; 14(4). PMID: 18835032
Role of macrophage targeting in the antitumor activity of trabectedin. Giovanni Germano, Roberta Frapolli, +21 authors, Paola Allavena. less Cancer Cell, 2013 Feb 16; 23(2). PMID: 23410977 Highly Cited.
Axitinib plus gemcitabine versus placebo plus gemcitabine in patients with advanced pancreatic adenocarcinoma: a double-blind randomised phase 3 study. Hedy L Kindler, Tatsuya Ioka, +14 authors, Eric Van Cutsem. less Lancet Oncol, 2011 Feb 11; 12(3). PMID: 21306953 Highly Cited.
Direct and differential suppression of myeloid-derived suppressor cell subsets by sunitinib is compartmentally constrained. Jennifer S Ko, Patricia Rayman, +6 authors, Peter A Cohen. less Cancer Res, 2010 Apr 22; 70(9). PMID: 20406969 Free PMC article. Highly Cited.
Regulation of tumor metastasis by myeloid-derived suppressor cells. Thomas Condamine, Indu Ramachandran, Je-In Youn, Dmitry I Gabrilovich. Annu Rev Med, 2014 Oct 24; 66. PMID: 25341012 Free PMC article. Highly Cited. Review.
Anti-metastatic potential of somatostatin analog SOM230: Indirect pharmacological targeting of pancreatic cancer-associated fibroblasts. Siham Moatassim-Billah, Camille Duluc, +11 authors, Corinne Bousquet. less Oncotarget, 2016 May 14; 7(27). PMID: 27177087 Free PMC article.
Reversion of immune tolerance in advanced malignancy: modulation of myeloid-derived suppressor cell development by blockade of stem-cell factor function. Ping-Ying Pan, George X Wang, +4 authors, Shu-Hsia Chen. less Blood, 2007 Sep 22; 111(1). PMID: 17885078 Free PMC article. Highly Cited.
Inhibition of Hedgehog signaling enhances delivery of chemotherapy in a mouse model of pancreatic cancer. Kenneth P Olive, Michael A Jacobetz, +34 authors, David A Tuveson. less Science, 2009 May 23; 324(5933). PMID: 19460966 Free PMC article. Highly Cited.
Hypoxia stimulates pancreatic stellate cells to induce fibrosis and angiogenesis in pancreatic cancer. Atsushi Masamune, Kazuhiro Kikuta, +3 authors, Tooru Shimosegawa. less Am J Physiol Gastrointest Liver Physiol, 2008 Aug 02; 295(4). PMID: 18669622
Myeloid-derived suppressor cells (MDSC) facilitate distant metastasis of malignancies by shielding circulating tumor cells (CTC) from immune surveillance. Qiaofei Liu, Quan Liao, Yupei Zhao. Med Hypotheses, 2016 Jan 31; 87. PMID: 26826638
Molecular mechanisms regulating myeloid-derived suppressor cell differentiation and function. Thomas Condamine, Dmitry I Gabrilovich. Trends Immunol, 2010 Nov 12; 32(1). PMID: 21067974 Free PMC article. Highly Cited. Review.
Comprehensive analysis of matrix metalloproteinase and tissue inhibitor expression in pancreatic cancer: increased expression of matrix metalloproteinase-7 predicts poor survival. Lucie E Jones, Michelle J Humphreys, +2 authors, Fiona Campbell, John P Neoptolemos, Mark T Boyd. less Clin Cancer Res, 2004 Apr 23; 10(8). PMID: 15102692
Human pancreatic stellate cells modulate 3D collagen alignment to promote the migration of pancreatic ductal adenocarcinoma cells. Cole R Drifka, Agnes G Loeffler, +3 authors, W John Kao. less Biomed Microdevices, 2016 Nov 08; 18(6). PMID: 27819128
Podoplanin-positive fibroblasts enhance lung adenocarcinoma tumor formation: podoplanin in fibroblast functions for tumor progression. Ayuko Hoshino, Genichiro Ishii, +5 authors, Atsushi Ochiai. less Cancer Res, 2011 May 26; 71(14). PMID: 21610106
Adjuvant chemotherapy of S-1 versus gemcitabine for resected pancreatic cancer: a phase 3, open-label, randomised, non-inferiority trial (JASPAC 01). Katsuhiko Uesaka, Narikazu Boku, +18 authors, JASPAC 01 Study Group. less Lancet, 2016 Jun 07; 388(10041). PMID: 27265347 Highly Cited.
The influence of myeloid-derived suppressor cells on angiogenesis and tumor growth after cancer surgery. Jun Wang, Xiaosan Su, +8 authors, Zhipeng Hong. less Int J Cancer, 2016 Jan 13; 138(11). PMID: 26756887
Myeloid-derived suppressor cells enhance stemness of cancer cells by inducing microRNA101 and suppressing the corepressor CtBP2. Tracy X Cui, Ilona Kryczek, +14 authors, Weiping Zou. less Immunity, 2013 Sep 10; 39(3). PMID: 24012420 Free PMC article. Highly Cited.
Tumor-associated macrophages exhibit pro- and anti-inflammatory properties by which they impact on pancreatic tumorigenesis. Ole Helm, Janka Held-Feindt, +10 authors, Susanne Sebens. less Int J Cancer, 2014 Jan 25; 135(4). PMID: 24458546 Highly Cited.
STAT3 regulates arginase-I in myeloid-derived suppressor cells from cancer patients. David Vasquez-Dunddel, Fan Pan, +9 authors, Young Kim. less J Clin Invest, 2013 Mar 05; 123(4). PMID: 23454751 Free PMC article. Highly Cited.
B cells regulate macrophage phenotype and response to chemotherapy in squamous carcinomas. Nesrine I Affara, Brian Ruffell, +13 authors, Lisa M Coussens. less Cancer Cell, 2014 Jun 10; 25(6). PMID: 24909985 Free PMC article. Highly Cited.
Pancreatic cancer-associated stellate cells: A viable target for reducing immunosuppression in the tumor microenvironment. Thomas A Mace, Mark Bloomston, Gregory B Lesinski. Oncoimmunology, 2013 Sep 28; 2(7). PMID: 24073373 Free PMC article.
Abrogation of TGF beta signaling in mammary carcinomas recruits Gr-1+CD11b+ myeloid cells that promote metastasis. Li Yang, Jianhua Huang, +8 authors, Harold L Moses. less Cancer Cell, 2008 Jan 03; 13(1). PMID: 18167337 Free PMC article. Highly Cited.
Pancreatic adenocarcinoma induces bone marrow mobilization of myeloid-derived suppressor cells which promote primary tumor growth. Matthew R Porembka, Jonathan B Mitchem, +6 authors, Peter Goedegebuure. less Cancer Immunol Immunother, 2012 Jan 05; 61(9). PMID: 22215137 Free PMC article. Highly Cited.
Cancer Stem Cells and Macrophages: Implications in Tumor Biology and Therapeutic Strategies. Bruno Sainz, Emily Carron, Mireia Vallespinós, Heather L Machado. Mediators Inflamm, 2016 Mar 17; 2016. PMID: 26980947 Free PMC article. Review.
The interaction of anticancer therapies with tumor-associated macrophages. Alberto Mantovani, Paola Allavena. J Exp Med, 2015 Mar 11; 212(4). PMID: 25753580 Free PMC article. Highly Cited. Review.
Activation of tumor-promoting type 2 macrophages by EGFR-targeting antibody cetuximab. Jan Pander, Moniek Heusinkveld, +7 authors, Thorbald van Hall. less Clin Cancer Res, 2011 Jul 27; 17(17). PMID: 21788356
Murine pancreatic adenocarcinoma dampens SHIP-1 expression and alters MDSC homeostasis and function. Shari Pilon-Thomas, Nadine Nelson, +4 authors, Tomar Ghansah. less PLoS One, 2011 Dec 02; 6(11). PMID: 22132131 Free PMC article.
Cancer treatment and survivorship statistics, 2016. Kimberly D Miller, Rebecca L Siegel, +6 authors, Ahmedin Jemal. less CA Cancer J Clin, 2016 Jun 03; 66(4). PMID: 27253694 Highly Cited.
Dynamic mast cell-stromal cell interactions promote growth of pancreatic cancer. Ying Ma, Rosa F Hwang, Craig D Logsdon, Stephen E Ullrich. Cancer Res, 2013 May 02; 73(13). PMID: 23633481 Free PMC article.
Macrophage polarization in pancreatic carcinoma: role of heparanase enzyme. Esther Hermano, Amichay Meirovitz, +4 authors, Michael Elkin. less J Natl Cancer Inst, 2014 Oct 19; 106(12). PMID: 25326645 Free PMC article.
Targeting the ANG2/TIE2 axis inhibits tumor growth and metastasis by impairing angiogenesis and disabling rebounds of proangiogenic myeloid cells. Roberta Mazzieri, Ferdinando Pucci, +8 authors, Michele De Palma. less Cancer Cell, 2011 Apr 13; 19(4). PMID: 21481792 Highly Cited.
Increase in frequency of myeloid-derived suppressor cells in mice with spontaneous pancreatic carcinoma. Fei Zhao, Sonja Obermann, +4 authors, Tim F Greten. less Immunology, 2009 Aug 20; 128(1). PMID: 19689743 Free PMC article.
The role of the hepatocyte growth factor/c-MET pathway in pancreatic stellate cell-endothelial cell interactions: antiangiogenic implications in pancreatic cancer. Mishaal B Patel, Srinivasa P Pothula, +5 authors, Jeremy S Wilson. less Carcinogenesis, 2014 May 31; 35(8). PMID: 24876152
High expression of Galectin-1 in pancreatic stellate cells plays a role in the development and maintenance of an immunosuppressive microenvironment in pancreatic cancer. Dong Tang, Zhongxu Yuan, +9 authors, Kuirong Jiang. less Int J Cancer, 2011 Jul 23; 130(10). PMID: 21780106
Endoneurial macrophages induce perineural invasion of pancreatic cancer cells by secretion of GDNF and activation of RET tyrosine kinase receptor. Oren Cavel, Olga Shomron, +8 authors, Ziv Gil. less Cancer Res, 2012 Sep 14; 72(22). PMID: 22971345
A STUDY OF THE LEUKEMOID RESPONSE TO TRANSPLANTABLE A-280 TUMOR IN MICE. E J LAPPAT, M CAWEIN. Cancer Res, 1964 Feb 01; 24. PMID: 14115699
High-throughput live-cell imaging reveals differential inhibition of tumor cell proliferation by human fibroblasts. Emilie Flaberg, Laszlo Markasz, +11 authors, Laszlo Szekely. less Int J Cancer, 2010 Aug 18; 128(12). PMID: 20715102
Myeloid-derived suppressor cell heterogeneity and subset definition. Elisa Peranzoni, Serena Zilio, +4 authors, Vincenzo Bronte. less Curr Opin Immunol, 2010 Feb 23; 22(2). PMID: 20171075 Highly Cited. Review.
Identification of fibroblast heterogeneity in the tumor microenvironment. Hikaru Sugimoto, Thomas M Mundel, Mark W Kieran, Raghu Kalluri. Cancer Biol Ther, 2006 Nov 16; 5(12). PMID: 17106243 Highly Cited.
Pancreatic stellate cell secreted IL-6 stimulates STAT3 dependent invasiveness of pancreatic intraepithelial neoplasia and cancer cells. Nagaraj S Nagathihalli, Jason A Castellanos, +5 authors, Nipun B Merchant. less Oncotarget, 2016 Sep 08; 7(40). PMID: 27602757 Free PMC article.
Angiotensin II drives the production of tumor-promoting macrophages. Virna Cortez-Retamozo, Martin Etzrodt, +21 authors, Mikael J Pittet. less Immunity, 2013 Jan 22; 38(2). PMID: 23333075 Free PMC article. Highly Cited.
CD271⁺ subpopulation of pancreatic stellate cells correlates with prognosis of pancreatic cancer and is regulated by interaction with cancer cells. Kenji Fujiwara, Kenoki Ohuchida, +8 authors, Masao Tanaka. less PLoS One, 2013 Jan 10; 7(12). PMID: 23300742 Free PMC article.
A randomized trial of chemoradiotherapy and chemotherapy after resection of pancreatic cancer. John P Neoptolemos, Deborah D Stocken, +14 authors, European Study Group for Pancreatic Cancer. less N Engl J Med, 2004 Mar 19; 350(12). PMID: 15028824 Highly Cited.
Interleukin 4 potently enhances murine macrophage mannose receptor activity: a marker of alternative immunologic macrophage activation. M Stein, S Keshav, N Harris, S Gordon. J Exp Med, 1992 Jul 01; 176(1). PMID: 1613462 Free PMC article. Highly Cited.
5-Fluorouracil selectively kills tumor-associated myeloid-derived suppressor cells resulting in enhanced T cell-dependent antitumor immunity. Julie Vincent, Grégoire Mignot, +7 authors, François Ghiringhelli. less Cancer Res, 2010 Apr 15; 70(8). PMID: 20388795 Highly Cited.
Galectin-1 is a novel functional receptor for tissue plasminogen activator in pancreatic cancer. Oriol Roda, Elena Ortiz-Zapater, +8 authors, Pilar Navarro. less Gastroenterology, 2009 Jan 28; 136(4). PMID: 19171142
Pancreatic stellate cells respond to inflammatory cytokines: potential role in chronic pancreatitis. P Mews, P Phillips, +4 authors, M Apte. less Gut, 2002 Mar 13; 50(4). PMID: 11889076 Free PMC article.
Hypoxia Inducible Factor 1 (HIF-1) Recruits Macrophage to Activate Pancreatic Stellate Cells in Pancreatic Ductal Adenocarcinoma. Na Li, Yang Li, +8 authors, He Ren. less Int J Mol Sci, 2016 Jun 09; 17(6). PMID: 27271610 Free PMC article.
Amino-biphosphonate-mediated MMP-9 inhibition breaks the tumor-bone marrow axis responsible for myeloid-derived suppressor cell expansion and macrophage infiltration in tumor stroma. Cecilia Melani, Sabina Sangaletti, +2 authors, Francesca M Barazzetta, Zena Werb, Mario P Colombo. less Cancer Res, 2007 Dec 07; 67(23). PMID: 18056472 Free PMC article. Highly Cited.
Inactivation of chemokine (C-C motif) receptor 1 (CCR1) suppresses colon cancer liver metastasis by blocking accumulation of immature myeloid cells in a mouse model. Takanori Kitamura, Teruaki Fujishita, +5 authors, Makoto M Taketo. less Proc Natl Acad Sci U S A, 2010 Jul 10; 107(29). PMID: 20616008 Free PMC article.
Apoptosis and anergy of T cell induced by pancreatic stellate cells-derived galectin-1 in pancreatic cancer. Dong Tang, Jun Gao, +10 authors, Kuirong Jiang. less Tumour Biol, 2015 Mar 03; 36(7). PMID: 25725585
Exclusion of T Cells From Pancreatic Carcinomas in Mice Is Regulated by Ly6C(low) F4/80(+) Extratumoral Macrophages. Gregory L Beatty, Rafael Winograd, +8 authors, Robert H Vonderheide. less Gastroenterology, 2015 Apr 19; 149(1). PMID: 25888329 Free PMC article. Highly Cited.
Fc-dependent depletion of tumor-infiltrating regulatory T cells co-defines the efficacy of anti-CTLA-4 therapy against melanoma. Tyler R Simpson, Fubin Li, +11 authors, Sergio A Quezada. less J Exp Med, 2013 Jul 31; 210(9). PMID: 23897981 Free PMC article. Highly Cited.
Update on phase I studies in advanced pancreatic adenocarcinoma. Hunting in darkness? Alexios S Strimpakos, Muhammad Wasif Saif. JOP, 2013 Jul 13; 14(4). PMID: 23846926
Periostin deposition in the stroma of invasive and intraductal neoplasms of the pancreas. Noriyoshi Fukushima, Yoshinao Kikuchi, +2 authors, Takashi Nishiyama, Akira Kudo, Masashi Fukayama. less Mod Pathol, 2008 May 20; 21(8). PMID: 18487994
Interleukin-27 inhibits malignant behaviors of pancreatic cancer cells by targeting M2 polarized tumor associated macrophages. Lutian Yao, Mengyi Wang, +5 authors, Yupei Zhao. less Cytokine, 2016 Feb 13; 89. PMID: 26868086
Cancer-associated fibroblasts in pancreatic adenocarcinoma. Boju Pan, Quan Liao, +2 authors, Zheyu Niu, Li Zhou, Yupei Zhao. less Future Oncol, 2015 Aug 19; 11(18). PMID: 26284509 Review.
M-1/M-2 macrophages and the Th1/Th2 paradigm. C D Mills, K Kincaid, +2 authors, J M Alt, M J Heilman, A M Hill. less J Immunol, 2000 Jun 08; 164(12). PMID: 10843666 Highly Cited.
Pancreatic fibroblast exosomes regulate survival of cancer cells. S Suklabaidya, P Dash, S Senapati. Oncogene, 2017 Feb 07; 36(25). PMID: 28166198
Persistent activation of pancreatic stellate cells creates a microenvironment favorable for the malignant behavior of pancreatic ductal adenocarcinoma. Dong Tang, Daorong Wang, +9 authors, Yi Miao. less Int J Cancer, 2012 Jul 11; 132(5). PMID: 22777597 Review.

Citedby
The critical roles of activated stellate cells-mediated paracrine signaling, metabolism and onco-immunology in pancreatic ductal adenocarcinoma. Yaojie Fu, Shanshan Liu, Shan Zeng, Hong Shen. Mol Cancer, 2018 Feb 21; 17(1). PMID: 29458370 Free PMC article. Review.
Phosphoinositide 3-Kinase Signaling Pathway in Pancreatic Ductal Adenocarcinoma Progression, Pathogenesis, and Therapeutics. Divya Murthy, Kuldeep S Attri, Pankaj K Singh. Front Physiol, 2018 Apr 20; 9. PMID: 29670543 Free PMC article. Review.
Tumor size classification of the 8th edition of TNM staging system is superior to that of the 7th edition in predicting the survival outcome of pancreatic cancer patients after radical resection and adjuvant chemotherapy. Lin Cong, Qiaofei Liu, +8 authors, Yupei Zhao. less Sci Rep, 2018 Jul 12; 8(1). PMID: 29991730 Free PMC article.
Complex interplay between tumor microenvironment and cancer therapy. Minhong Shen, Yibin Kang. Front Med, 2018 Aug 12; 12(4). PMID: 30097962 Review.
Harnessing the Immune System in Pancreatic Cancer. Satya Das, Jordan Berlin, Dana Cardin. Curr Treat Options Oncol, 2018 Aug 22; 19(10). PMID: 30128712 Free PMC article. Review.
Does Axl have potential as a therapeutic target in pancreatic cancer? Wenting Du, Rolf A Brekken. Expert Opin Ther Targets, 2018 Sep 25; 22(11). PMID: 30244621 Free PMC article. Review.
Emerging Role of Immune Checkpoint Blockade in Pancreatic Cancer. Shravanti Macherla, Shachar Laks, +3 authors, Mahvish Muzaffar. less Int J Mol Sci, 2018 Nov 09; 19(11). PMID: 30405053 Free PMC article. Review.
Tenascin-C Modulates Cell Cycle Progression to Enhance Tumour Cell Proliferation through AKT/FOXO1 Signalling in Pancreatic Cancer. Jun Cai, Wenli Lu, +4 authors, Xiaohong Shen. less J Cancer, 2018 Dec 07; 9(23). PMID: 30519351 Free PMC article.
Crosshatch nanofiber networks of tunable interfiber spacing induce plasticity in cell migration and cytoskeletal response. Aniket Jana, Intawat Nookaew, +3 authors, Amrinder S Nain. less FASEB J, 2019 Jun 22; 33(10). PMID: 31225977 Free PMC article.
Role of the complement system in the tumor microenvironment. Ronghua Zhang, Qiaofei Liu, +2 authors, Tong Li, Quan Liao, Yupei Zhao. less Cancer Cell Int, 2019 Dec 04; 19. PMID: 31787848 Free PMC article. Review.
Circulating Tumor DNA-Based Detection of Microsatellite Instability and Response to Immunotherapy in Pancreatic Cancer. Saivaishnavi Kamatham, Faisal Shahjehan, Pashtoon Murtaza Kasi. Front Pharmacol, 2020 Mar 03; 11. PMID: 32116700 Free PMC article.
The Proteomic Landscape of Pancreatic Ductal Adenocarcinoma Liver Metastases Identifies Molecular Subtypes and Associations with Clinical Response. Henry C-H Law, Dragana Lagundžin, +13 authors, Nicholas T Woods. less Clin Cancer Res, 2019 Dec 19; 26(5). PMID: 31848187 Free PMC article.
CXCL5 overexpression predicts a poor prognosis in pancreatic ductal adenocarcinoma and is correlated with immune cell infiltration. Ronghua Zhang, Qiaofei Liu, +8 authors, Yupei Zhao. less J Cancer, 2020 Mar 24; 11(9). PMID: 32201508 Free PMC article.
Pancreatic Cancer, Gut Microbiota, and Therapeutic Efficacy. Xiang Zhang, Qiaofei Liu, Quan Liao, Yupei Zhao. J Cancer, 2020 Apr 01; 11(10). PMID: 32226493 Free PMC article. Review.
A Combination of Radiotherapy, Hyperthermia, and Immunotherapy Inhibits Pancreatic Tumor Growth and Prolongs the Survival of Mice. Javed Mahmood, Allen A Alexander, +7 authors, Zeljko Vujaskovic. less Cancers (Basel), 2020 Apr 25; 12(4). PMID: 32326142 Free PMC article.
Polymer nanoparticle-assisted chemotherapy of pancreatic cancer. Tianqi Su, Bo Yang, +2 authors, Tianren Gao, Tongjun Liu, Jiannan Li. less Ther Adv Med Oncol, 2020 May 20; 12. PMID: 32426046 Free PMC article. Review.
Circular RNA and tumor microenvironment. Huixin Song, Qiaofei Liu, Quan Liao. Cancer Cell Int, 2020 Jun 11; 20. PMID: 32518520 Free PMC article. Review.
Identification of a novel IL-5 signaling pathway in chronic pancreatitis and crosstalk with pancreatic tumor cells. Sarah B Gitto, Jordan M Beardsley, +8 authors, Deborah A Altomare. less Cell Commun Signal, 2020 Jun 20; 18(1). PMID: 32552827 Free PMC article.
Stage IA Patients With Pancreatic Ductal Adenocarcinoma Cannot Benefit From Chemotherapy: A Propensity Score Matching Study. Yuchao Zhang, Gang Xu, +5 authors, Ping Wang. less Front Oncol, 2020 Aug 09; 10. PMID: 32766130 Free PMC article.
CAFs and TGF-β Signaling Activation by Mast Cells Contribute to Resistance to Gemcitabine/Nabpaclitaxel in Pancreatic Cancer. Letizia Porcelli, Rosa Maria Iacobazzi, +8 authors, Nicola Silvestris. less Cancers (Basel), 2019 Mar 15; 11(3). PMID: 30866547 Free PMC article. Highly Cited.
Long noncoding RNA: a dazzling dancer in tumor immune microenvironment. Yalu Zhang, Qiaofei Liu, Quan Liao. J Exp Clin Cancer Res, 2020 Nov 06; 39(1). PMID: 33148302 Free PMC article. Review.
Ocoxin Oral Solution Exerts an Antitumoral Effect in Pancreatic Cancer and Reduces the Stromal-Mediated Chemoresistance. Iera Hernandez-Unzueta, Aitor Benedicto, +5 authors, Joana Márquez. less Pancreas, 2019 Apr 05; 48(4). PMID: 30946238 Free PMC article.
Therapeutic challenges and current immunomodulatory strategies in targeting the immunosuppressive pancreatic tumor microenvironment. Chin-King Looi, Felicia Fei-Lei Chung, +3 authors, Chun-Wai Mai. less J Exp Clin Cancer Res, 2019 Apr 17; 38(1). PMID: 30987642 Free PMC article. Highly Cited. Review.
Immune-Based Therapies and the Role of Microsatellite Instability in Pancreatic Cancer. Michele Ghidini, Andrea Lampis, +4 authors, Jens C Hahne. less Genes (Basel), 2021 Jan 02; 12(1). PMID: 33383713 Free PMC article. Review.
Dilemma and Challenge of Immunotherapy for Pancreatic Cancer. Jia Wu, Jianting Cai. Dig Dis Sci, 2020 Mar 07; 66(2). PMID: 32140943 Review.
The effects of nuclear factor-kappa B in pancreatic stellate cells on inflammation and fibrosis of chronic pancreatitis. Nan Wu, Xiao-Fan Xu, +6 authors, Hong Zhang. less J Cell Mol Med, 2020 Dec 31; 25(4). PMID: 33377616 Free PMC article.
Identification of Prognostic and Therapeutic Biomarkers among FAM83 Family Members for Pancreatic Ductal Adenocarcinoma. Zuyi Ma, Zixuan Zhou, +10 authors, Baohua Hou. less Dis Markers, 2021 Mar 23; 2021. PMID: 33747255 Free PMC article.
High Expression of PD-L1 Is Associated with Better Survival in Pancreatic/Periampullary Cancers and Correlates with Epithelial to Mesenchymal Transition. Nishant Thakur, Kwang Yeol Paik, Gyoyeon Hwang, Yosep Chong. Diagnostics (Basel), 2021 Apr 04; 11(4). PMID: 33810560 Free PMC article.
Pancreatic Cancer Signaling Pathways, Genetic Alterations, and Tumor Microenvironment: The Barriers Affecting the Method of Treatment. Darya Javadrashid, Amir Baghbanzadeh, +5 authors, Behzad Baradaran. less Biomedicines, 2021 May 01; 9(4). PMID: 33918146 Free PMC article. Review.
In Vivo Assessment of Hypoxia Levels in Pancreatic Tumors Using a Dual-Modality Ultrasound/Photoacoustic Imaging System. Yuhling Wang, De-Fu Jhang, +6 authors, Lun-De Liao. less Micromachines (Basel), 2021 Jul 03; 12(6). PMID: 34200388 Free PMC article.
Therapeutic Potential of Targeting Stromal Crosstalk-Mediated Immune Suppression in Pancreatic Cancer. Wenting Du, Marina Pasca di Magliano, Yaqing Zhang. Front Oncol, 2021 Jul 23; 11. PMID: 34290984 Free PMC article. Review.
AXL Is a Key Factor for Cell Plasticity and Promotes Metastasis in Pancreatic Cancer. Wenting Du, Natalie Z Phinney, +8 authors, Rolf A Brekken. less Mol Cancer Res, 2021 Apr 04; 19(8). PMID: 33811159 Free PMC article.
Pan-Cancer Analysis of Immune Complement Signature C3/C5/C3AR1/C5AR1 in Association with Tumor Immune Evasion and Therapy Resistance. Bashir Lawal, Sung-Hui Tseng, +6 authors, Alexander T H Wu. less Cancers (Basel), 2021 Aug 28; 13(16). PMID: 34439277 Free PMC article.
Immune-Related Circulating miR-125b-5p and miR-99a-5p Reveal a High Recurrence Risk Group of Pancreatic Cancer Patients after Tumor Resection. Eveline E Vietsch, Ivana Peran, +5 authors, Anton Wellstein. less Appl Sci (Basel), 2019 Nov 02; 9(22). PMID: 34484811 Free PMC article.
The Function of cGAS-STING Pathway in Treatment of Pancreatic Cancer. Ghazal Mohseni, Juan Li, +3 authors, Chuanxin Wang. less Front Immunol, 2021 Dec 04; 12. PMID: 34858438 Free PMC article. Review.
Anti-Cancer Activity Profiling of Chemotherapeutic Agents in 3D Co-Cultures of Pancreatic Tumor Spheroids with Cancer-Associated Fibroblasts and Macrophages. So-Dam Jang, Jeeyeun Song, +4 authors, Hyo-Jeong Kuh. less Cancers (Basel), 2021 Dec 11; 13(23). PMID: 34885065 Free PMC article.
Size-dependent chemosensitization of doxorubicin-loaded polymeric nanoparticles for malignant glioma chemotherapy. Meng Gao, Yue Chen, Chenghu Wu. Bioengineered, 2021 Nov 17; 12(2). PMID: 34783631 Free PMC article.
Complement System: An Immunotherapy Target in Colorectal Cancer. Iman M Talaat, Noha Mousaad Elemam, Maha Saber-Ayad. Front Immunol, 2022 Feb 18; 13. PMID: 35173724 Free PMC article. Review.
Identification of New Regulators of Pancreatic Cancer Cell Sensitivity to Oxaliplatin and Cisplatin. Vera Skripova, Ramilia Vlasenkova, +2 authors, Yan Zhou, Igor Astsaturov, Ramziya Kiyamova. less Molecules, 2022 Feb 26; 27(4). PMID: 35209078 Free PMC article.
Identify potential prognostic indicators and tumor-infiltrating immune cells in pancreatic adenocarcinoma. Ting Shi, Ge Gao. Biosci Rep, 2022 Jan 28; 42(2). PMID: 35083488 Free PMC article. Review.
Predictive Biomarkers for a Personalized Approach in Resectable Pancreatic Cancer. Valeria Merz, Domenico Mangiameli, +11 authors, Davide Melisi. less Front Surg, 2022 May 24; 9. PMID: 35599791 Free PMC article. Review.

BioKDE: Biomedical Knowledge Discovery Engine

Abstract

Other Links