. 2017 Jul; 14(12):717-734.
doi: 10.1038/nrclinonc.2017.101.

The immune contexture in cancer prognosis and treatment

Wolf H Fridman 1 Laurence Zitvogel 2 Catherine Sautès-Fridman 1 Guido Kroemer 3 
  • PMID: 28741618
  •     198 References
  •     419 citations


Immunotherapy is currently the most rapidly advancing area of clinical oncology, and provides the unprecedented opportunity to effectively treat, and even cure, several previously untreatable malignancies. A growing awareness exists of the fact that the success of chemotherapy and radiotherapy, in which the patient's disease can be stabilized well beyond discontinuation of treatment (and occasionally is cured), also relies on the induction of a durable anticancer immune response. Indeed, the local immune infiltrate undergoes dynamic changes that accompany a shift from a pre-existing immune response to a therapy-induced immune response. As a result, the immune contexture, which is determined by the density, composition, functional state and organization of the leukocyte infiltrate of the tumour, can yield information that is relevant to prognosis, prediction of a treatment response and various other pharmacodynamic parameters. Several complementary technologies can be used to explore the immune contexture of tumours, and to derive biomarkers that could enable the adaptation of individual treatment approaches for each patient, as well as monitoring a response to anticancer therapies.

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François Ghiringhelli, Cedric Menard, +7 authors, Bruno Chauffert.
Cancer Immunol Immunother, 2006 Sep 09; 56(5). PMID: 16960692
Highly Cited.
Immunogenic cell death in cancer and infectious disease.
Lorenzo Galluzzi, Aitziber Buqué, +2 authors, Guido Kroemer.
Nat Rev Immunol, 2016 Nov 01; 17(2). PMID: 27748397
Highly Cited. Review.
Immunological off-target effects of imatinib.
Laurence Zitvogel, Sylvie Rusakiewicz, +2 authors, Guido Kroemer.
Nat Rev Clin Oncol, 2016 Apr 01; 13(7). PMID: 27030078
Localization and density of immune cells in the invasive margin of human colorectal cancer liver metastases are prognostic for response to chemotherapy.
Niels Halama, Sara Michel, +16 authors, Dirk Jaeger.
Cancer Res, 2011 Aug 19; 71(17). PMID: 21846824
Highly Cited.
Tumour-associated macrophage polarisation and re-education with immunotherapy.
Debra H Josephs, Heather J Bax, Sophia N Karagiannis.
Front Biosci (Elite Ed), 2015 Jan 02; 7. PMID: 25553381
Type, density, and location of immune cells within human colorectal tumors predict clinical outcome.
Jérôme Galon, Anne Costes, +13 authors, Franck Pagès.
Science, 2006 Sep 30; 313(5795). PMID: 17008531
Highly Cited.
Immunological and biological changes during ipilimumab treatment and their potential correlation with clinical response and survival in patients with advanced melanoma.
Ester Simeone, Giusy Gentilcore, +20 authors, Paolo A Ascierto.
Cancer Immunol Immunother, 2014 Apr 04; 63(7). PMID: 24695951
Highly Cited.
Integrative Analyses of Colorectal Cancer Show Immunoscore Is a Stronger Predictor of Patient Survival Than Microsatellite Instability.
Bernhard Mlecnik, Gabriela Bindea, +29 authors, Jérôme Galon.
Immunity, 2016 Mar 18; 44(3). PMID: 26982367
Highly Cited.
Orchestration and Prognostic Significance of Immune Checkpoints in the Microenvironment of Primary and Metastatic Renal Cell Cancer.
Nicolas A Giraldo, Etienne Becht, +17 authors, Catherine Sautès-Fridman.
Clin Cancer Res, 2015 Feb 18; 21(13). PMID: 25688160
Highly Cited.
Calreticulin exposure by malignant blasts correlates with robust anticancer immunity and improved clinical outcome in AML patients.
Jitka Fucikova, Iva Truxova, +12 authors, Radek Spisek.
Blood, 2016 Nov 03; 128(26). PMID: 27802968    Free PMC article.
The consensus molecular subtypes of colorectal cancer.
Justin Guinney, Rodrigo Dienstmann, +37 authors, Sabine Tejpar.
Nat Med, 2015 Oct 13; 21(11). PMID: 26457759    Free PMC article.
Highly Cited.
The Dynamics of Apoptotic Cell Clearance.
Michael R Elliott, Kodi S Ravichandran.
Dev Cell, 2016 Jul 28; 38(2). PMID: 27459067    Free PMC article.
Highly Cited. Review.
Cancer cell-autonomous contribution of type I interferon signaling to the efficacy of chemotherapy.
Antonella Sistigu, Takahiro Yamazaki, +48 authors, Laurence Zitvogel.
Nat Med, 2014 Oct 27; 20(11). PMID: 25344738
Highly Cited.
Prognostic and theranostic impact of molecular subtypes and immune classifications in renal cell cancer (RCC) and colorectal cancer (CRC).
Etienne Becht, Nicolas A Giraldo, +9 authors, Wolf Herman Fridman.
Oncoimmunology, 2015 Nov 21; 4(12). PMID: 26587318    Free PMC article.
Immunogenic cell death in cancer therapy.
Guido Kroemer, Lorenzo Galluzzi, Oliver Kepp, Laurence Zitvogel.
Annu Rev Immunol, 2012 Nov 20; 31. PMID: 23157435
Highly Cited. Review.
Chemokine receptor patterns in lymphocytes mirror metastatic spreading in melanoma.
Nicolas Jacquelot, David P Enot, +27 authors, Laurence Zitvogel.
J Clin Invest, 2016 Feb 09; 126(3). PMID: 26854930    Free PMC article.
Calreticulin exposure on malignant blasts predicts a cellular anticancer immune response in patients with acute myeloid leukemia.
M Wemeau, O Kepp, +6 authors, N Chaput.
Cell Death Dis, 2010 Jan 01; 1. PMID: 21368877    Free PMC article.
Up-regulation of PD-L1, IDO, and T(regs) in the melanoma tumor microenvironment is driven by CD8(+) T cells.
Stefani Spranger, Robbert M Spaapen, +4 authors, Thomas F Gajewski.
Sci Transl Med, 2013 Aug 30; 5(200). PMID: 23986400    Free PMC article.
Highly Cited.
Improved survival with T cell clonotype stability after anti-CTLA-4 treatment in cancer patients.
Edward Cha, Mark Klinger, +4 authors, Lawrence Fong.
Sci Transl Med, 2014 May 30; 6(238). PMID: 24871131    Free PMC article.
Highly Cited.
Silencing of Irf7 pathways in breast cancer cells promotes bone metastasis through immune escape.
Bradley N Bidwell, Clare Y Slaney, +15 authors, Belinda S Parker.
Nat Med, 2012 Jul 24; 18(8). PMID: 22820642
Highly Cited.
Accumulation of MDSC and Th17 Cells in Patients with Metastatic Colorectal Cancer Predicts the Efficacy of a FOLFOX-Bevacizumab Drug Treatment Regimen.
Emeric Limagne, Romain Euvrard, +12 authors, François Ghiringhelli.
Cancer Res, 2016 Aug 09; 76(18). PMID: 27496709
Highly Cited.
Prognostic and predictive impact of intra- and peritumoral immune infiltrates.
Wolf Herman Fridman, Jérôme Galon, +3 authors, Guido Kroemer.
Cancer Res, 2011 Aug 19; 71(17). PMID: 21846822
Highly Cited. Review.
Ectopic lymphoid structures function as microniches for tumor progenitor cells in hepatocellular carcinoma.
Shlomi Finkin, Detian Yuan, +18 authors, Eli Pikarsky.
Nat Immunol, 2015 Oct 27; 16(12). PMID: 26502405    Free PMC article.
Highly Cited.
Comprehensive genomic analysis identifies novel subtypes and targets of triple-negative breast cancer.
Matthew D Burstein, Anna Tsimelzon, +10 authors, Powel H Brown.
Clin Cancer Res, 2014 Sep 12; 21(7). PMID: 25208879    Free PMC article.
Highly Cited.
Prognostic significance of activated cytotoxic T-lymphocytes in primary nodal diffuse large B-cell lymphomas.
J J F Muris, C J L M Meijer, +9 authors, J J Oudejans.
Leukemia, 2004 Jan 09; 18(3). PMID: 14712286
Bladder cancer.
Ashish M Kamat, Noah M Hahn, +6 authors, Wassim Kassouf.
Lancet, 2016 Jun 28; 388(10061). PMID: 27345655
Highly Cited. Review.
Induction of cytotoxic granules in human memory CD8+ T cell subsets requires cell cycle progression.
Yuru Meng, Helena Harlin, James P O'Keefe, Thomas F Gajewski.
J Immunol, 2006 Jul 20; 177(3). PMID: 16849512
Tumor-Infiltrating and Peripheral Blood T-cell Immunophenotypes Predict Early Relapse in Localized Clear Cell Renal Cell Carcinoma.
Nicolas A Giraldo, Etienne Becht, +13 authors, Catherine Sautès-Fridman.
Clin Cancer Res, 2017 Feb 19; 23(15). PMID: 28213366
Highly Cited.
Defective immunogenic cell death of HMGB1-deficient tumors: compensatory therapy with TLR4 agonists.
T Yamazaki, D Hannani, +11 authors, L Zitvogel.
Cell Death Differ, 2013 Jul 03; 21(1). PMID: 23811849    Free PMC article.
Highly Cited.
Biological network-driven gene selection identifies a stromal immune module as a key determinant of triple-negative breast carcinoma prognosis.
H Bonsang-Kitzis, B Sadacca, +4 authors, F Reyal.
Oncoimmunology, 2016 Mar 05; 5(1). PMID: 26942074    Free PMC article.
Safety, efficacy, and biomarkers of nivolumab with vaccine in ipilimumab-refractory or -naive melanoma.
Jeffrey S Weber, Ragini Reiney Kudchadkar, +11 authors, Y Ann Chen.
J Clin Oncol, 2013 Oct 23; 31(34). PMID: 24145345    Free PMC article.
Highly Cited.
Combined evaluation of LC3B puncta and HMGB1 expression predicts residual risk of relapse after adjuvant chemotherapy in breast cancer.
Sylvain Ladoire, Frédérique Penault-Llorca, +17 authors, Guido Kroemer.
Autophagy, 2015 Oct 29; 11(10). PMID: 26506894    Free PMC article.
The prognostic landscape of genes and infiltrating immune cells across human cancers.
Andrew J Gentles, Aaron M Newman, +11 authors, Ash A Alizadeh.
Nat Med, 2015 Jul 21; 21(8). PMID: 26193342    Free PMC article.
Highly Cited.
Molecular subtypes of clear cell renal cell carcinoma are associated with sunitinib response in the metastatic setting.
Benoit Beuselinck, Sylvie Job, +16 authors, Jessica Zucman-Rossi.
Clin Cancer Res, 2015 Jan 15; 21(6). PMID: 25583177
A prospective phase II trial exploring the association between tumor microenvironment biomarkers and clinical activity of ipilimumab in advanced melanoma.
Omid Hamid, Henrik Schmidt, +9 authors, David Berman.
J Transl Med, 2011 Nov 30; 9. PMID: 22123319    Free PMC article.
Highly Cited.
Human melanomas and ovarian cancers overexpressing mechanical barrier molecule genes lack immune signatures and have increased patient mortality risk.
Elise P Salerno, Davide Bedognetti, +9 authors, Craig L Slingluff.
Oncoimmunology, 2017 Jan 27; 5(12). PMID: 28123876    Free PMC article.
Pan-Cancer Immunogenomic Perspective on the Tumor Microenvironment Based on PD-L1 and CD8 T-Cell Infiltration.
Chan-Young Ock, Bhumsuk Keam, +7 authors, Dae Seog Heo.
Clin Cancer Res, 2016 Jan 29; 22(9). PMID: 26819449
Highly Cited.
Novel Radiotracer for ImmunoPET Imaging of PD-1 Checkpoint Expression on Tumor Infiltrating Lymphocytes.
Arutselvan Natarajan, Aaron T Mayer, +3 authors, Sanjiv S Gambhir.
Bioconjug Chem, 2015 Aug 27; 26(10). PMID: 26307602
Tumor aneuploidy correlates with markers of immune evasion and with reduced response to immunotherapy.
Teresa Davoli, Hajime Uno, Eric C Wooten, Stephen J Elledge.
Science, 2017 Jan 21; 355(6322). PMID: 28104840    Free PMC article.
Highly Cited.
Genomic correlates of response to CTLA-4 blockade in metastatic melanoma.
Eliezer M Van Allen, Diana Miao, +19 authors, Levi A Garraway.
Science, 2015 Sep 12; 350(6257). PMID: 26359337    Free PMC article.
Highly Cited.
Leukocyte composition of human breast cancer.
Brian Ruffell, Alfred Au, +3 authors, Lisa M Coussens.
Proc Natl Acad Sci U S A, 2011 Aug 10; 109(8). PMID: 21825174    Free PMC article.
Highly Cited.
Spatiotemporal dynamics of intratumoral immune cells reveal the immune landscape in human cancer.
Gabriela Bindea, Bernhard Mlecnik, +14 authors, Jérôme Galon.
Immunity, 2013 Oct 22; 39(4). PMID: 24138885
Highly Cited.
Tumor exome analysis reveals neoantigen-specific T-cell reactivity in an ipilimumab-responsive melanoma.
Nienke van Rooij, Marit M van Buuren, +14 authors, Ton N Schumacher.
J Clin Oncol, 2013 Sep 18; 31(32). PMID: 24043743    Free PMC article.
Highly Cited.
Autophagy-dependent anticancer immune responses induced by chemotherapeutic agents in mice.
Mickaël Michaud, Isabelle Martins, +16 authors, Guido Kroemer.
Science, 2011 Dec 17; 334(6062). PMID: 22174255
Highly Cited.
Radiation and dual checkpoint blockade activate non-redundant immune mechanisms in cancer.
Christina Twyman-Saint Victor, Andrew J Rech, +22 authors, Andy J Minn.
Nature, 2015 Mar 11; 520(7547). PMID: 25754329    Free PMC article.
Highly Cited.
The presence of LC3B puncta and HMGB1 expression in malignant cells correlate with the immune infiltrate in breast cancer.
Sylvain Ladoire, David Enot, +13 authors, Guido Kroemer.
Autophagy, 2016 Mar 17; 12(5). PMID: 26979828    Free PMC article.
Highly Cited.
Immunological Effects of Conventional Chemotherapy and Targeted Anticancer Agents.
Lorenzo Galluzzi, Aitziber Buqué, +2 authors, Guido Kroemer.
Cancer Cell, 2015 Dec 19; 28(6). PMID: 26678337
Highly Cited. Review.
Effector T Cells Abrogate Stroma-Mediated Chemoresistance in Ovarian Cancer.
Weimin Wang, Ilona Kryczek, +18 authors, Weiping Zou.
Cell, 2016 May 03; 165(5). PMID: 27133165    Free PMC article.
Highly Cited.
The host STING pathway at the interface of cancer and immunity.
Leticia Corrales, Sarah M McWhirter, Thomas W Dubensky, Thomas F Gajewski.
J Clin Invest, 2016 Jul 02; 126(7). PMID: 27367184    Free PMC article.
Highly Cited. Review.
ICP34.5 protein of herpes simplex virus facilitates the initiation of protein translation by bridging eukaryotic initiation factor 2alpha (eIF2alpha) and protein phosphatase 1.
Yapeng Li, Cuizhu Zhang, +8 authors, Youjia Cao.
J Biol Chem, 2011 May 31; 286(28). PMID: 21622569    Free PMC article.
Neoadjuvant Chemotherapy of Ovarian Cancer Results in Three Patterns of Tumor-Infiltrating Lymphocyte Response with Distinct Implications for Immunotherapy.
Charlotte S Lo, Sanaz Sanii, +7 authors, Brad H Nelson.
Clin Cancer Res, 2016 Sep 08; 23(4). PMID: 27601594
Relevance of Tumor-Infiltrating Immune Cell Composition and Functionality for Disease Outcome in Breast Cancer.
Rico D Bense, Christos Sotiriou, +5 authors, Rudolf S N Fehrmann.
J Natl Cancer Inst, 2016 Oct 16; 109(1). PMID: 27737921    Free PMC article.
Highly Cited.
Baseline Biomarkers for Outcome of Melanoma Patients Treated with Pembrolizumab.
Benjamin Weide, Alexander Martens, +24 authors, Jedd D Wolchok.
Clin Cancer Res, 2016 Nov 01; 22(22). PMID: 27185375    Free PMC article.
Highly Cited.
Decoding cell death signals in inflammation and immunity.
Laurence Zitvogel, Oliver Kepp, Guido Kroemer.
Cell, 2010 Mar 23; 140(6). PMID: 20303871
Highly Cited.
Phase II multicenter trial of maintenance biotherapy after induction concurrent Biochemotherapy for patients with metastatic melanoma.
Steven J O'Day, Michael B Atkins, +8 authors, Jeffrey S Weber.
J Clin Oncol, 2009 Nov 18; 27(36). PMID: 19917850
Alternatively spliced NKp30 isoforms affect the prognosis of gastrointestinal stromal tumors.
Nicolas F Delahaye, Sylvie Rusakiewicz, +38 authors, Laurence Zitvogel.
Nat Med, 2011 May 10; 17(6). PMID: 21552268
Highly Cited.
Cyclophosphamide induces a type I interferon-associated sterile inflammatory response signature in cancer patients' blood cells: implications for cancer chemoimmunotherapy.
Federica Moschella, Giovanni Fernando Torelli, +7 authors, Enrico Proietti.
Clin Cancer Res, 2013 Jun 14; 19(15). PMID: 23759676
Pembrolizumab for the treatment of non-small-cell lung cancer.
Edward B Garon, Naiyer A Rizvi, +25 authors, KEYNOTE-001 Investigators.
N Engl J Med, 2015 Apr 22; 372(21). PMID: 25891174
Highly Cited.
CD73 is associated with poor prognosis in HNSCC.
Zhen-Hu Ren, Cheng-Zhong Lin, +12 authors, Chen-Ping Zhang.
Oncotarget, 2016 Aug 25; 7(38). PMID: 27557512    Free PMC article.
Tertiary lymphoid tissue in the tumor microenvironment: from its occurrence to immunotherapeutic implications.
Giuseppe Di Caro, Giovanni Francesco Castino, +5 authors, Federica Marchesi.
Int Rev Immunol, 2015 Apr 23; 34(2). PMID: 25901857
In Situ Mapping of Innate Lymphoid Cells in Human Skin: Evidence for Remarkable Differences between Normal and Inflamed Skin.
Marie-Charlotte Brüggen, Wolfgang M Bauer, +7 authors, Georg Stingl.
J Invest Dermatol, 2016 Jul 28; 136(12). PMID: 27456756
CANCER IMMUNOLOGY. The "cancer immunogram".
Christian U Blank, John B Haanen, Antoni Ribas, Ton N Schumacher.
Science, 2016 May 07; 352(6286). PMID: 27151852
Highly Cited.
The secret ally: immunostimulation by anticancer drugs.
Lorenzo Galluzzi, Laura Senovilla, Laurence Zitvogel, Guido Kroemer.
Nat Rev Drug Discov, 2012 Feb 04; 11(3). PMID: 22301798
Highly Cited. Review.
Intratumor heterogeneity and branched evolution revealed by multiregion sequencing.
Marco Gerlinger, Andrew J Rowan, +28 authors, Charles Swanton.
N Engl J Med, 2012 Mar 09; 366(10). PMID: 22397650    Free PMC article.
Highly Cited.
Adaptive resistance to therapeutic PD-1 blockade is associated with upregulation of alternative immune checkpoints.
Shohei Koyama, Esra A Akbay, +23 authors, Peter S Hammerman.
Nat Commun, 2016 Feb 18; 7. PMID: 26883990    Free PMC article.
Highly Cited.
Neoantigens in cancer immunotherapy.
Ton N Schumacher, Robert D Schreiber.
Science, 2015 Apr 04; 348(6230). PMID: 25838375
Highly Cited. Review.
The immune contexture in human tumours: impact on clinical outcome.
Wolf Herman Fridman, Franck Pagès, Catherine Sautès-Fridman, Jérôme Galon.
Nat Rev Cancer, 2012 Mar 16; 12(4). PMID: 22419253
Highly Cited. Review.
Immune and Stromal Classification of Colorectal Cancer Is Associated with Molecular Subtypes and Relevant for Precision Immunotherapy.
Etienne Becht, Aurélien de Reyniès, +7 authors, Wolf Herman Fridman.
Clin Cancer Res, 2016 Mar 20; 22(16). PMID: 26994146
Highly Cited.
Innate Immune Landscape in Early Lung Adenocarcinoma by Paired Single-Cell Analyses.
Yonit Lavin, Soma Kobayashi, +26 authors, Miriam Merad.
Cell, 2017 May 06; 169(4). PMID: 28475900    Free PMC article.
Highly Cited.
Immunosuppressive plasma cells impede T-cell-dependent immunogenic chemotherapy.
Shabnam Shalapour, Joan Font-Burgada, +13 authors, Michael Karin.
Nature, 2015 Apr 30; 521(7550). PMID: 25924065    Free PMC article.
Highly Cited.
Regulation of the innate and adaptive immune responses by Stat-3 signaling in tumor cells.
Tianhong Wang, Guilian Niu, +11 authors, Hua Yu.
Nat Med, 2004 Jan 02; 10(1). PMID: 14702634
Highly Cited.
Chemotherapy-induced antitumor immunity requires formyl peptide receptor 1.
Erika Vacchelli, Yuting Ma, +39 authors, Guido Kroemer.
Science, 2015 Oct 31; 350(6263). PMID: 26516201
Highly Cited.
Genomic and Transcriptomic Features of Response to Anti-PD-1 Therapy in Metastatic Melanoma.
Willy Hugo, Jesse M Zaretsky, +15 authors, Roger S Lo.
Cell, 2016 Mar 22; 165(1). PMID: 26997480    Free PMC article.
Highly Cited.
Prognostic value of tumor infiltrating NK cells and macrophages in stage II+III esophageal cancer patients.
Bin Xu, Lujun Chen, +4 authors, Jingting Jiang.
Oncotarget, 2016 Oct 14; 7(46). PMID: 27736796    Free PMC article.
Combined Nivolumab and Ipilimumab or Monotherapy in Untreated Melanoma.
James Larkin, Vanna Chiarion-Sileni, +28 authors, Jedd D Wolchok.
N Engl J Med, 2015 Jun 02; 373(1). PMID: 26027431    Free PMC article.
Highly Cited.
Primary, Adaptive, and Acquired Resistance to Cancer Immunotherapy.
Padmanee Sharma, Siwen Hu-Lieskovan, Jennifer A Wargo, Antoni Ribas.
Cell, 2017 Feb 12; 168(4). PMID: 28187290    Free PMC article.
Highly Cited. Review.
Prospective identification of neoantigen-specific lymphocytes in the peripheral blood of melanoma patients.
Alena Gros, Maria R Parkhurst, +11 authors, Steven A Rosenberg.
Nat Med, 2016 Feb 24; 22(4). PMID: 26901407    Free PMC article.
Highly Cited.
Colocalization of inflammatory response with B7-h1 expression in human melanocytic lesions supports an adaptive resistance mechanism of immune escape.
Janis M Taube, Robert A Anders, +8 authors, Lieping Chen.
Sci Transl Med, 2012 Mar 31; 4(127). PMID: 22461641    Free PMC article.
Highly Cited.
Tumor-intrinsic oncogene pathways mediating immune avoidance.
Stefani Spranger, Thomas F Gajewski.
Oncoimmunology, 2016 May 04; 5(3). PMID: 27141343    Free PMC article.
Highly Cited. Review.
PD-1 Blockade in Tumors with Mismatch-Repair Deficiency.
Dung T Le, Jennifer N Uram, +32 authors, Luis A Diaz.
N Engl J Med, 2015 Jun 02; 372(26). PMID: 26028255    Free PMC article.
Highly Cited.
Melanoma-specific MHC-II expression represents a tumour-autonomous phenotype and predicts response to anti-PD-1/PD-L1 therapy.
Douglas B Johnson, Monica V Estrada, +18 authors, Justin M Balko.
Nat Commun, 2016 Jan 30; 7. PMID: 26822383    Free PMC article.
Highly Cited.
The EGFR-specific antibody cetuximab combined with chemotherapy triggers immunogenic cell death.
Chiara Pozzi, Alessandro Cuomo, +12 authors, Maria Rescigno.
Nat Med, 2016 May 03; 22(6). PMID: 27135741
Highly Cited.
Host immunity contributes to the anti-melanoma activity of BRAF inhibitors.
Deborah A Knight, Shin Foong Ngiow, +11 authors, Mark J Smyth.
J Clin Invest, 2013 Mar 05; 123(3). PMID: 23454771    Free PMC article.
Highly Cited.
Dissecting the multicellular ecosystem of metastatic melanoma by single-cell RNA-seq.
Itay Tirosh, Benjamin Izar, +34 authors, Levi A Garraway.
Science, 2016 Apr 29; 352(6282). PMID: 27124452    Free PMC article.
Highly Cited.
Mutations Associated with Acquired Resistance to PD-1 Blockade in Melanoma.
Jesse M Zaretsky, Angel Garcia-Diaz, +26 authors, Antoni Ribas.
N Engl J Med, 2016 Jul 20; 375(9). PMID: 27433843    Free PMC article.
Highly Cited.
LDHA-Associated Lactic Acid Production Blunts Tumor Immunosurveillance by T and NK Cells.
Almut Brand, Katrin Singer, +36 authors, Marina Kreutz.
Cell Metab, 2016 Sep 20; 24(5). PMID: 27641098
Highly Cited.
Characteristics and clinical impacts of the immune environments in colorectal and renal cell carcinoma lung metastases: influence of tumor origin.
Romain Remark, Marco Alifano, +17 authors, Diane Damotte.
Clin Cancer Res, 2013 Jun 21; 19(15). PMID: 23785047
Highly Cited.
5-Fluorouracil selectively kills tumor-associated myeloid-derived suppressor cells resulting in enhanced T cell-dependent antitumor immunity.
Julie Vincent, Grégoire Mignot, +7 authors, François Ghiringhelli.
Cancer Res, 2010 Apr 15; 70(8). PMID: 20388795
Highly Cited.
Tumor Interferon Signaling Regulates a Multigenic Resistance Program to Immune Checkpoint Blockade.
Joseph L Benci, Bihui Xu, +16 authors, Andy J Minn.
Cell, 2016 Dec 03; 167(6). PMID: 27912061    Free PMC article.
Highly Cited.
Tumor-infiltrating lymphocytes and response to neoadjuvant chemotherapy with or without carboplatin in human epidermal growth factor receptor 2-positive and triple-negative primary breast cancers.
Carsten Denkert, Gunter von Minckwitz, +27 authors, Sibylle Loibl.
J Clin Oncol, 2014 Dec 24; 33(9). PMID: 25534375
Highly Cited.
The intestinal microbiota modulates the anticancer immune effects of cyclophosphamide.
Sophie Viaud, Fabiana Saccheri, +30 authors, Laurence Zitvogel.
Science, 2013 Nov 23; 342(6161). PMID: 24264990    Free PMC article.
Highly Cited.
Sunitinib pretreatment improves tumor-infiltrating lymphocyte expansion by reduction in intratumoral content of myeloid-derived suppressor cells in human renal cell carcinoma.
Aurelie Guislain, Jules Gadiot, +8 authors, Christian U Blank.
Cancer Immunol Immunother, 2015 Jun 25; 64(10). PMID: 26105626
Resistance Mechanisms to Immune-Checkpoint Blockade in Cancer: Tumor-Intrinsic and -Extrinsic Factors.
Jonathan M Pitt, Marie Vétizou, +8 authors, Laurence Zitvogel.
Immunity, 2016 Jun 23; 44(6). PMID: 27332730
Highly Cited. Review.
Accessories to the crime: functions of cells recruited to the tumor microenvironment.
Douglas Hanahan, Lisa M Coussens.
Cancer Cell, 2012 Mar 24; 21(3). PMID: 22439926
Highly Cited. Review.
Primary Resistance to PD-1 Blockade Mediated by JAK1/2 Mutations.
Daniel Sanghoon Shin, Jesse M Zaretsky, +24 authors, Antoni Ribas.
Cancer Discov, 2016 Dec 03; 7(2). PMID: 27903500    Free PMC article.
Highly Cited.
Impact of the Tumor Microenvironment on Tumor-Infiltrating Lymphocytes: Focus on Breast Cancer.
Ivan J Cohen, Ronald Blasberg.
Breast Cancer (Auckl), 2017 Oct 06; 11. PMID: 28979132    Free PMC article.
Cancer Immunotherapy Getting Brainy: Visualizing the Distinctive CNS Metastatic Niche to Illuminate Therapeutic Resistance.
Mark Owyong, Niloufar Hosseini-Nassab, +4 authors, Bryan Ronain Smith.
Drug Resist Updat, 2017 Nov 18; 33-35. PMID: 29145972    Free PMC article.
Trial watch: Immune checkpoint blockers for cancer therapy.
Claire Vanpouille-Box, Claire Lhuillier, +10 authors, Lorenzo Galluzzi.
Oncoimmunology, 2017 Nov 18; 6(11). PMID: 29147629    Free PMC article.
Highly Cited. Review.
Trial Watch: Immunostimulatory monoclonal antibodies for oncological indications.
Mariona Cabo, Rienk Offringa, +3 authors, Lorenzo Galluzzi.
Oncoimmunology, 2017 Dec 07; 6(12). PMID: 29209572    Free PMC article.
Emerging biomarkers for the combination of radiotherapy and immune checkpoint blockers.
Claire Lhuillier, Claire Vanpouille-Box, +2 authors, Sandra Demaria.
Semin Cancer Biol, 2017 Dec 21; 52(Pt 2). PMID: 29258856    Free PMC article.
Maturation of tertiary lymphoid structures and recurrence of stage II and III colorectal cancer.
Florian Posch, Karina Silina, +15 authors, Thomas Winder.
Oncoimmunology, 2018 Feb 09; 7(2). PMID: 29416939    Free PMC article.
Next Generation Immunotherapy for Pancreatic Cancer: DNA Vaccination is Seeking New Combo Partners.
Paola Cappello, Claudia Curcio, +3 authors, Francesco Novelli.
Cancers (Basel), 2018 Feb 22; 10(2). PMID: 29462900    Free PMC article.
Phenotypic and Functional Properties of Tumor-Infiltrating Regulatory T Cells.
Gap Ryol Lee.
Mediators Inflamm, 2018 Feb 22; 2017. PMID: 29463952    Free PMC article.
The inflammation - cancer connection.
Alberto Mantovani.
FEBS J, 2018 Feb 27; 285(4). PMID: 29479848    Free PMC article.
The Peripheral and Intratumoral Immune Cell Landscape in Cancer Patients: A Proxy for Tumor Biology and a Tool for Outcome Prediction.
Annette Schnell, Christian Schmidl, Wolfgang Herr, Peter J Siska.
Biomedicines, 2018 Mar 03; 6(1). PMID: 29495308    Free PMC article.
Type I Interferon-Independent Dendritic Cell Priming and Antitumor T Cell Activation Induced by a Mycoplasma fermentans Lipopeptide.
Yohei Takeda, Masahiro Azuma, +3 authors, Tsukasa Seya.
Front Immunol, 2018 Mar 30; 9. PMID: 29593736    Free PMC article.
Expression of LLT1 and its receptor CD161 in lung cancer is associated with better clinical outcome.
Véronique M Braud, Jérôme Biton, +13 authors, Claire Germain.
Oncoimmunology, 2018 May 04; 7(5). PMID: 29721382    Free PMC article.
Temporal changes in immune cell composition and cytokines in response to chemoradiation in rectal cancer.
Yong Joon Lee, Sat Byol Lee, +6 authors, Byung Soh Min.
Sci Rep, 2018 May 17; 8(1). PMID: 29765096    Free PMC article.
Interferon-Gamma at the Crossroads of Tumor Immune Surveillance or Evasion.
Flávia Castro, Ana Patrícia Cardoso, +2 authors, Maria José Oliveira.
Front Immunol, 2018 May 22; 9. PMID: 29780381    Free PMC article.
Highly Cited. Review.
High neutrophil to lymphocyte ratio and decreased CD69+NK cells represent a phenotype of high risk in early-stage breast cancer patients.
Pablo Mandó, Manglio Rizzo, +9 authors, Estrella Mariel Levy.
Onco Targets Ther, 2018 May 31; 11. PMID: 29844687    Free PMC article.
Development of immunotherapy in bladder cancer: present and future on targeting PD(L)1 and CTLA-4 pathways.
Mathieu Rouanne, Mathieu Roumiguié, +7 authors, Yann Neuzillet.
World J Urol, 2018 Jun 02; 36(11). PMID: 29855698
Cancer immunotherapy: broadening the scope of targetable tumours.
Jitske van den Bulk, Els Me Verdegaal, Noel Fcc de Miranda.
Open Biol, 2018 Jun 08; 8(6). PMID: 29875199    Free PMC article.
Proton beam therapy and immunotherapy: an emerging partnership for immune activation in non-small cell lung cancer.
Howard J Lee, Jing Zeng, Ramesh Rengan.
Transl Lung Cancer Res, 2018 Jun 08; 7(2). PMID: 29876317    Free PMC article.
TIME (Tumor Immunity in the MicroEnvironment) classification based on tumor CD274 (PD-L1) expression status and tumor-infiltrating lymphocytes in colorectal carcinomas.
Tsuyoshi Hamada, Thing Rinda Soong, +28 authors, Shuji Ogino.
Oncoimmunology, 2018 Jun 15; 7(7). PMID: 29900052    Free PMC article.
Optimized dendritic cell vaccination induces potent CD8 T cell responses and anti-tumor effects in transgenic mouse melanoma models.
Mareike Grees, Adi Sharbi-Yunger, +8 authors, Viktor Umansky.
Oncoimmunology, 2018 Jun 15; 7(7). PMID: 29900058    Free PMC article.
The Prognostic Value of Immune Factors in the Tumor Microenvironment of Penile Squamous Cell Carcinoma.
Sarah Rosanne Ottenhof, Rosa Sanne Djajadiningrat, +7 authors, Ekaterina Straschimirova Jordanova.
Front Immunol, 2018 Jun 27; 9. PMID: 29942303    Free PMC article.
The Role of Immune Escape and Immune Cell Infiltration in Breast Cancer.
André Steven, Barbara Seliger.
Breast Care (Basel), 2018 Jun 29; 13(1). PMID: 29950962    Free PMC article.
Immune cell profiling in the age of immune checkpoint inhibitors: implications for biomarker discovery and understanding of resistance mechanisms.
Su Yin Lim, Helen Rizos.
Mamm Genome, 2018 Jul 04; 29(11-12). PMID: 29968076    Free PMC article.
Pan-cancer deconvolution of tumour composition using DNA methylation.
Ankur Chakravarthy, Andrew Furness, +10 authors, Tim R Fenton.
Nat Commun, 2018 Aug 15; 9(1). PMID: 30104673    Free PMC article.
Tumor Mutation Burden as a Biomarker in Resected Non-Small-Cell Lung Cancer.
Siddhartha Devarakonda, Federico Rotolo, +17 authors, Stefan Michiels.
J Clin Oncol, 2018 Aug 15; 36(30). PMID: 30106638    Free PMC article.
Highly Cited.
The Paradoxical Role of NKG2D in Cancer Immunity.
Sam Sheppard, Amir Ferry, Joana Guedes, Nadia Guerra.
Front Immunol, 2018 Aug 29; 9. PMID: 30150983    Free PMC article.
Virus and tumor microenvironment induced ER stress and unfolded protein response: from complexity to therapeutics.
Kumari Asha, Neelam Sharma-Walia.
Oncotarget, 2018 Aug 31; 9(61). PMID: 30159133    Free PMC article.
Magnetic resonance imaging and molecular features associated with tumor-infiltrating lymphocytes in breast cancer.
Jia Wu, Xuejie Li, +4 authors, Ruijiang Li.
Breast Cancer Res, 2018 Sep 05; 20(1). PMID: 30176944    Free PMC article.
Topography of cancer-associated immune cells in human solid tumors.
Jakob Nikolas Kather, Meggy Suarez-Carmona, +17 authors, Niels Halama.
Elife, 2018 Sep 05; 7. PMID: 30179157    Free PMC article.
Highly Cited.
Resident memory T cells, critical components in tumor immunology.
Fathia Mami-Chouaib, Charlotte Blanc, +5 authors, Eric Tartour.
J Immunother Cancer, 2018 Sep 06; 6(1). PMID: 30180905    Free PMC article.
Immuno-Oncology: Emerging Targets and Combination Therapies.
Henry T Marshall, Mustafa B A Djamgoz.
Front Oncol, 2018 Sep 08; 8. PMID: 30191140    Free PMC article.
Highly Cited. Review.
Vitamin D status after colorectal cancer diagnosis and patient survival according to immune response to tumour.
Tsuyoshi Hamada, Li Liu, +27 authors, Shuji Ogino.
Eur J Cancer, 2018 Sep 17; 103. PMID: 30219720    Free PMC article.
Heating it up: Oncolytic viruses make tumors 'hot' and suitable for checkpoint blockade immunotherapies.
Shashi Gujar, Jonathan G Pol, Guido Kroemer.
Oncoimmunology, 2018 Sep 18; 7(8). PMID: 30221036    Free PMC article.
Fusobacterium nucleatum in Colorectal Cancer Relates to Immune Response Differentially by Tumor Microsatellite Instability Status.
Tsuyoshi Hamada, Xuehong Zhang, +29 authors, Shuji Ogino.
Cancer Immunol Res, 2018 Sep 20; 6(11). PMID: 30228205    Free PMC article.
Impact of chemotactic factors and receptors on the cancer immune infiltrate: a bioinformatics study revealing homogeneity and heterogeneity among patient cohorts.
Gautier Stoll, Jonathan Pol, +2 authors, Guido Kroemer.
Oncoimmunology, 2018 Oct 06; 7(10). PMID: 30288345    Free PMC article.
Role of Hypoxic Stress in Regulating Tumor Immunogenicity, Resistance and Plasticity.
Stéphane Terry, Rania Faouzi Zaarour, +6 authors, Salem Chouaib.
Int J Mol Sci, 2018 Oct 12; 19(10). PMID: 30301213    Free PMC article.
Endogenous Galectin-1 in T Lymphocytes Regulates Anti-prostate Cancer Immunity.
Enrique Corapi, Gustavo Carrizo, Daniel Compagno, Diego Laderach.
Front Immunol, 2018 Oct 16; 9. PMID: 30319642    Free PMC article.
Quantitative Analyses of the Tumor Microenvironment Composition and Orientation in the Era of Precision Medicine.
Florent Petitprez, Cheng-Ming Sun, +3 authors, Wolf H Fridman.
Front Oncol, 2018 Oct 16; 8. PMID: 30319963    Free PMC article.
Multi-Omics Profiling of the Tumor Microenvironment: Paving the Way to Precision Immuno-Oncology.
Francesca Finotello, Federica Eduati.
Front Oncol, 2018 Oct 23; 8. PMID: 30345255    Free PMC article.
Targeting Chemokines and Chemokine Receptors in Melanoma and Other Cancers.
Nicolas Jacquelot, Connie P M Duong, Gabrielle T Belz, Laurence Zitvogel.
Front Immunol, 2018 Nov 14; 9. PMID: 30420855    Free PMC article.
Resistance to anti-PD-1-based immunotherapy in basal cell carcinoma: a case report and review of the literature.
Francesco Sabbatino, Antonio Marra, +5 authors, Stefano Pepe.
J Immunother Cancer, 2018 Nov 22; 6(1). PMID: 30458852    Free PMC article.
Prognostic significance of tumor genotypes and CD8+ infiltrates in stage I-III colorectal cancer.
Elena Fountzilas, Vassiliki Kotoula, +18 authors, George Fountzilas.
Oncotarget, 2018 Nov 28; 9(86). PMID: 30479693    Free PMC article.
Functional Heterogeneity of CD4+ Tumor-Infiltrating Lymphocytes With a Resident Memory Phenotype in NSCLC.
Anna E Oja, Berber Piet, +8 authors, Pleun Hombrink.
Front Immunol, 2018 Dec 07; 9. PMID: 30505306    Free PMC article.
Antigen Specificity and Clinical Significance of IgG and IgA Autoantibodies Produced in situ by Tumor-Infiltrating B Cells in Breast Cancer.
Soizic Garaud, Pawel Zayakin, +7 authors, Aija Linē.
Front Immunol, 2018 Dec 06; 9. PMID: 30515157    Free PMC article.
PD-L2 amplification and durable disease stabilization in patient with urothelial carcinoma receiving pembrolizumab.
Saby George, Antonios Papanicolau-Sengos, +11 authors, Carl Morrison.
Oncoimmunology, 2018 Dec 14; 7(12). PMID: 30524881    Free PMC article.
Responsiveness to anti-PD-1 and anti-CTLA-4 immune checkpoint blockade in SB28 and GL261 mouse glioma models.
Vassilis Genoud, Eliana Marinari, +5 authors, Paul R Walker.
Oncoimmunology, 2018 Dec 14; 7(12). PMID: 30524896    Free PMC article.
Potent immunosuppressive effects of the oncometabolite R-2-hydroxyglutarate.
Lorenzo Galluzzi, Guido Kroemer.
Oncoimmunology, 2018 Dec 14; 7(12). PMID: 30524910    Free PMC article.
Mature dendritic cells correlate with favorable immune infiltrate and improved prognosis in ovarian carcinoma patients.
Iva Truxova, Lenka Kasikova, +17 authors, Jitka Fucikova.
J Immunother Cancer, 2018 Dec 12; 6(1). PMID: 30526667    Free PMC article.
Systemic autophagy in the therapeutic response to anthracycline-based chemotherapy.
Francesca Castoldi, Erika Vacchelli, +3 authors, Guido Kroemer.
Oncoimmunology, 2018 Dec 14; 8(1). PMID: 30546941    Free PMC article.
Interferon-γ induces cancer cell ferroptosis.
Laurence Zitvogel, Guido Kroemer.
Cell Res, 2019 Jun 05; 29(9). PMID: 31160718    Free PMC article.
Epidemiologic perspectives on immunosuppressed populations and the immunosurveillance and immunocontainment of cancer.
Eric A Engels.
Am J Transplant, 2019 Jun 18; 19(12). PMID: 31206226    Free PMC article.
Brainwashed by extracellular vesicles: the role of extracellular vesicles in primary and metastatic brain tumour microenvironment.
Golnaz Morad, Marsha A Moses.
J Extracell Vesicles, 2019 Jul 06; 8(1). PMID: 31275532    Free PMC article.
Immune Heterogeneity Between Primary Tumors and Corresponding Metastatic Lesions and Response to Platinum Therapy in Primary Ovarian Cancer.
Katharina Dötzer, Friederike Schlüter, +10 authors, Barbara Mayer.
Cancers (Basel), 2019 Aug 29; 11(9). PMID: 31455033    Free PMC article.
The Evolving Landscape of Biomarkers for Anti-PD-1 or Anti-PD-L1 Therapy.
Antje Tunger, Ulrich Sommer, +7 authors, Marc Schmitz.
J Clin Med, 2019 Sep 29; 8(10). PMID: 31557787    Free PMC article.
Sourcing the immune system to induce immunogenic cell death in Kras-colorectal cancer cells.
Mara Cirone, Lavinia Vittoria Lotti, +9 authors, Livio Mallucci.
Br J Cancer, 2019 Sep 29; 121(9). PMID: 31558803    Free PMC article.
STAT3 and STAT5 Targeting for Simultaneous Management of Melanoma and Autoimmune Diseases.
Stella Logotheti, Brigitte M Pützer.
Cancers (Basel), 2019 Oct 02; 11(10). PMID: 31569642    Free PMC article.
The correlation of BER protein, IRF3 with CD8+ T cell and their prognostic significance in upper tract urothelial carcinoma.
Lin-Ang Wang, Bo Yang, +3 authors, Jun Jiang.
Onco Targets Ther, 2019 Oct 03; 12. PMID: 31576137    Free PMC article.
The Construction and Comprehensive Analysis of ceRNA Networks and Tumor-Infiltrating Immune Cells in Bone Metastatic Melanoma.
Runzhi Huang, Zhiwei Zeng, +10 authors, Zongqiang Huang.
Front Genet, 2019 Oct 15; 10. PMID: 31608101    Free PMC article.
Non-nuclear AR Signaling in Prostate Cancer.
Alice Zamagni, Michela Cortesi, Michele Zanoni, Anna Tesei.
Front Chem, 2019 Oct 17; 7. PMID: 31616657    Free PMC article.
IL27Rα Deficiency Alters Endothelial Cell Function and Subverts Tumor Angiogenesis in Mammary Carcinoma.
Annika F Fink, Giorgia Ciliberti, +6 authors, Bernhard Brüne.
Front Oncol, 2019 Oct 23; 9. PMID: 31637217    Free PMC article.
The Microenvironment of Pituitary Tumors-Biological and Therapeutic Implications.
Mirela Diana Ilie, Alexandre Vasiljevic, Gérald Raverot, Philippe Bertolino.
Cancers (Basel), 2019 Oct 24; 11(10). PMID: 31640258    Free PMC article.
Macrophages induce CD47 upregulation via IL-6 and correlate with poor survival in hepatocellular carcinoma patients.
Jing Chen, Dan-Xue Zheng, +4 authors, Jing Xu.
Oncoimmunology, 2019 Oct 28; 8(11). PMID: 31646099    Free PMC article.
Lurbinectedin synergizes with immune checkpoint blockade to generate anticancer immunity.
Wei Xie, Sabrina Forveille, +9 authors, Oliver Kepp.
Oncoimmunology, 2019 Oct 28; 8(11). PMID: 31646106    Free PMC article.
Dendritic Cell Vaccination in Metastatic Melanoma Turns "Non-T Cell Inflamed" Into "T-Cell Inflamed" Tumors.
Jenny Bulgarelli, Marcella Tazzari, +14 authors, Massimo Guidoboni.
Front Immunol, 2019 Oct 28; 10. PMID: 31649669    Free PMC article.
Imaging of T-cells and their responses during anti-cancer immunotherapy.
Massis Krekorian, Gilbert O Fruhwirth, +4 authors, Erik H J G Aarntzen.
Theranostics, 2019 Oct 28; 9(25). PMID: 31656546    Free PMC article.
Revising PTEN in the Era of Immunotherapy: New Perspectives for an Old Story.
Geny Piro, Carmine Carbone, +6 authors, Giampaolo Tortora.
Cancers (Basel), 2019 Oct 30; 11(10). PMID: 31658667    Free PMC article.
Immune Checkpoint Inhibition in Hodgkin Lymphoma.
Ryan H Moy, Anas Younes.
Hemasphere, 2018 Feb 16; 2(1). PMID: 31723749    Free PMC article.
Tumor-intrinsic signaling pathways: key roles in the regulation of the immunosuppressive tumor microenvironment.
Li Yang, Aitian Li, Qingyang Lei, Yi Zhang.
J Hematol Oncol, 2019 Nov 30; 12(1). PMID: 31775797    Free PMC article.
Tumor Characterization in Breast Cancer Identifies Immune-Relevant Gene Signatures Associated With Prognosis.
Jie Li, Cun Liu, +7 authors, Changgang Sun.
Front Genet, 2019 Nov 30; 10. PMID: 31781173    Free PMC article.
Proteolytic chemokine cleavage as a regulator of lymphocytic infiltration in solid tumors.
Holger Bronger, Viktor Magdolen, Peter Goettig, Tobias Dreyer.
Cancer Metastasis Rev, 2019 Sep 05; 38(3). PMID: 31482487    Free PMC article.
The reciprocal regulation between host tissue and immune cells in pancreatic ductal adenocarcinoma: new insights and therapeutic implications.
Xiaomeng Liu, Jin Xu, +6 authors, Si Shi.
Mol Cancer, 2019 Dec 14; 18(1). PMID: 31831007    Free PMC article.
Human leucocyte antigen class I in hormone receptor-positive, HER2-negative breast cancer: association with response and survival after neoadjuvant chemotherapy.
Bruno Valentin Sinn, Karsten E Weber, +15 authors, Sibylle Loibl.
Breast Cancer Res, 2019 Dec 13; 21(1). PMID: 31829264    Free PMC article.
Biomarker for personalized immunotherapy.
Si-Yang Liu, Yi-Long Wu.
Transl Lung Cancer Res, 2019 Dec 21; 8(Suppl 3). PMID: 31857954    Free PMC article.
Targeting of the Cancer-Associated Fibroblast-T-Cell Axis in Solid Malignancies.
Tom J Harryvan, Els M E Verdegaal, +2 authors, Sjoerd H van der Burg.
J Clin Med, 2019 Nov 17; 8(11). PMID: 31731701    Free PMC article.
Clinical and transcriptional signatures of human CD204 reveal an applicable marker for the protumor phenotype of tumor-associated macrophages in breast cancer.
Yunjie He, Siying Zhou, +10 authors, Zuomin Zhou.
Aging (Albany NY), 2019 Dec 05; 11(23). PMID: 31799941    Free PMC article.
Tumour immune cell infiltration and survival after platinum-based chemotherapy in high-grade serous ovarian cancer subtypes: A gene expression-based computational study.
Rong Liu, Rong Hu, +2 authors, Hong-Hao Zhou.
EBioMedicine, 2020 Jan 09; 51. PMID: 31911269    Free PMC article.
CTLA-4 correlates with immune and clinical characteristics of glioma.
Fangkun Liu, Jing Huang, +3 authors, Zhixiong Liu.
Cancer Cell Int, 2020 Jan 09; 20. PMID: 31911758    Free PMC article.
Relevance of arm somatic copy number alterations for oncologic outcomes and tumor immune microenvironment in clear cell renal cell carcinoma.
Ying Xiong, Yu Qi, +3 authors, Jianming Guo.
Ann Transl Med, 2020 Jan 14; 7(22). PMID: 31930047    Free PMC article.
The prognostic effect of immunoscore in patients with clear cell renal cell carcinoma: preliminary results.
Ismail Selvi, Umut Demirci, Nazan Bozdogan, Halil Basar.
Int Urol Nephrol, 2019 Sep 22; 52(1). PMID: 31541404
Disparity in Tumor Immune Microenvironment of Breast Cancer and Prognostic Impact: Asian Versus Western Populations.
Ching-Hsuan Chen, Yen-Shen Lu, +8 authors, Ching-Hung Lin.
Oncologist, 2019 Aug 03; 25(1). PMID: 31371522    Free PMC article.
Resistance of melanoma to immune checkpoint inhibitors is overcome by targeting the sphingosine kinase-1.
Caroline Imbert, Anne Montfort, +20 authors, Céline Colacios.
Nat Commun, 2020 Jan 25; 11(1). PMID: 31974367    Free PMC article.
Apparent Lack of BRAF Derived HLA Class I Presented Neoantigens Hampers Neoplastic Cell Targeting by CD8+ T Cells in Langerhans Cell Histiocytosis.
Paul G Kemps, Timo C Zondag, +24 authors, Astrid G S van Halteren.
Front Immunol, 2020 Jan 31; 10. PMID: 31998317    Free PMC article.
Clinicopathological and Prognostic Characteristics of CD276 (B7-H3) Expression in Adrenocortical Carcinoma.
Jiayu Liang, Zhihong Liu, +12 authors, Yuchun Zhu.
Dis Markers, 2020 Jan 31; 2020. PMID: 31998416    Free PMC article.
Innate Lymphoid Cells in Colorectal Cancers: A Double-Edged Sword.
Qiutong Huang, Wang Cao, +3 authors, Nicolas Jacquelot.
Front Immunol, 2020 Feb 06; 10. PMID: 32010138    Free PMC article.
Beyond PD-L1 Markers for Lung Cancer Immunotherapy.
Kamila Wojas-Krawczyk, Ewa Kalinka, +2 authors, Janusz Milanowski.
Int J Mol Sci, 2019 Apr 21; 20(8). PMID: 31003463    Free PMC article.
Multi-dimensional omics characterization in glioblastoma identifies the purity-associated pattern and prognostic gene signatures.
Yi Xiong, Zujian Xiong, +3 authors, Xuejun Li.
Cancer Cell Int, 2020 Feb 06; 20. PMID: 32021566    Free PMC article.
Predictive biomarkers for immune checkpoint blockade and opportunities for combination therapies.
Hongxing Shen, Eddy Shih-Hsin Yang, +4 authors, Lewis Zhichang Shi.
Genes Dis, 2020 Feb 12; 6(3). PMID: 32042863    Free PMC article.
Very rapid cloning, expression and identifying specificity of T-cell receptors for T-cell engineering.
Shan Zong, Tiejuan Mi, +7 authors, Hiroki Torikai.
PLoS One, 2020 Feb 11; 15(2). PMID: 32040512    Free PMC article.
Smoking and Risk of Colorectal Cancer Sub-Classified by Tumor-Infiltrating T Cells.
Tsuyoshi Hamada, Jonathan A Nowak, +23 authors, Shuji Ogino.
J Natl Cancer Inst, 2018 Oct 13; 111(1). PMID: 30312431    Free PMC article.
The Immune Subtypes and Landscape of Squamous Cell Carcinoma.
Bailiang Li, Yi Cui, +2 authors, Ruijiang Li.
Clin Cancer Res, 2019 Mar 06; 25(12). PMID: 30833271    Free PMC article.
Bidirectional Crosstalk Between Cancer Stem Cells and Immune Cell Subsets.
Luise Müller, Antje Tunger, +6 authors, Marc Schmitz.
Front Immunol, 2020 Mar 03; 11. PMID: 32117287    Free PMC article.
Biohybrid Vaccines for Improved Treatment of Aggressive Melanoma with Checkpoint Inhibitor.
Flavia Fontana, Manlio Fusciello, +9 authors, Hélder A Santos.
ACS Nano, 2019 May 18; 13(6). PMID: 31100004    Free PMC article.
Prognostic and predictive role of tumour-associated macrophages in HER2 positive breast cancer.
Tiia J Honkanen, Antti Tikkanen, +3 authors, Jussi P Koivunen.
Sci Rep, 2019 Jul 31; 9(1). PMID: 31358801    Free PMC article.
The intimate relationship between gut microbiota and cancer immunotherapy.
Arielle Elkrief, Lisa Derosa, +2 authors, Bertrand Routy.
Gut Microbes, 2018 Oct 20; 10(3). PMID: 30339501    Free PMC article.
The clinical role of the TME in solid cancer.
Nicolas A Giraldo, Rafael Sanchez-Salas, +8 authors, Catherine Sautès-Fridman.
Br J Cancer, 2018 Nov 11; 120(1). PMID: 30413828    Free PMC article.
Immune biomarkers of response to immune-checkpoint inhibitors in head and neck squamous cell carcinoma.
M Oliva, A Spreafico, +4 authors, L L Siu.
Ann Oncol, 2018 Nov 22; 30(1). PMID: 30462163    Free PMC article.
Blocking IL-1β reverses the immunosuppression in mouse breast cancer and synergizes with anti-PD-1 for tumor abrogation.
Irena Kaplanov, Yaron Carmi, +6 authors, Ron N Apte.
Proc Natl Acad Sci U S A, 2018 Dec 14; 116(4). PMID: 30545915    Free PMC article.
Highly Cited.
Rethinking Communication in the Immune System: The Quorum Sensing Concept.
Luca Antonioli, Corrado Blandizzi, +2 authors, György Haskó.
Trends Immunol, 2019 Jan 07; 40(2). PMID: 30611647    Free PMC article.
Integration of microbiology, molecular pathology, and epidemiology: a new paradigm to explore the pathogenesis of microbiome-driven neoplasms.
Tsuyoshi Hamada, Jonathan A Nowak, +2 authors, Shuji Ogino.
J Pathol, 2019 Jan 12; 247(5). PMID: 30632609    Free PMC article.
Highly Cited. Review.
Immune cell constitution in bone marrow microenvironment predicts outcome in adult ALL.
Helena Hohtari, Oscar Brück, +7 authors, Satu Mustjoki.
Leukemia, 2019 Jan 13; 33(7). PMID: 30635636    Free PMC article.
Hyperspectral cell sociology reveals spatial tumor-immune cell interactions associated with lung cancer recurrence.
Katey S S Enfield, Spencer D Martin, +10 authors, Martial Guillaud.
J Immunother Cancer, 2019 Jan 18; 7(1). PMID: 30651131    Free PMC article.
A multi-institutional study of bladder-preserving therapy for stage II-IV bladder cancer: A Korean Radiation Oncology Group Study (KROG 14-16).
Sang Jun Byun, Won Park, +5 authors, Jin Hee Kim.
PLoS One, 2019 Jan 18; 14(1). PMID: 30653591    Free PMC article.
Endosomolytic polymersomes increase the activity of cyclic dinucleotide STING agonists to enhance cancer immunotherapy.
Daniel Shae, Kyle W Becker, +8 authors, John T Wilson.
Nat Nanotechnol, 2019 Jan 22; 14(3). PMID: 30664751    Free PMC article.
Highly Cited.
Common risk factors for heart failure and cancer.
Wouter C Meijers, Rudolf A de Boer.
Cardiovasc Res, 2019 Feb 05; 115(5). PMID: 30715247    Free PMC article.
Highly Cited. Review.
Prognostic Value of Macrophage Phenotypes in Resectable Non-Small Cell Lung Cancer Assessed by Multiplex Immunohistochemistry.
Mehrdad Rakaee, Lill-Tove Rasmussen Busund, +7 authors, Thomas K Kilvaer.
Neoplasia, 2019 Feb 12; 21(3). PMID: 30743162    Free PMC article.
Highly Cited.
Collagen density regulates the activity of tumor-infiltrating T cells.
Dorota E Kuczek, Anne Mette H Larsen, +12 authors, Daniel H Madsen.
J Immunother Cancer, 2019 Mar 15; 7(1). PMID: 30867051    Free PMC article.
Drug Repositioning Inferred from E2F1-Coregulator Interactions Studies for the Prevention and Treatment of Metastatic Cancers.
Deborah Goody, Shailendra K Gupta, +13 authors, Brigitte M Pützer.
Theranostics, 2019 Mar 15; 9(5). PMID: 30867845    Free PMC article.
Wnt1 silences chemokine genes in dendritic cells and induces adaptive immune resistance in lung adenocarcinoma.
Dimitra Kerdidani, Panagiotis Chouvardas, +12 authors, Maria Tsoumakidou.
Nat Commun, 2019 Mar 31; 10(1). PMID: 30926812    Free PMC article.
Cutting Edge: Polymicrobial Sepsis Has the Capacity to Reinvigorate Tumor-Infiltrating CD8 T Cells and Prolong Host Survival.
Derek B Danahy, Isaac J Jensen, Thomas S Griffith, Vladimir P Badovinac.
J Immunol, 2019 Apr 12; 202(10). PMID: 30971442    Free PMC article.
Cancer cells induce immune escape via glycocalyx changes controlled by the telomeric protein TRF2.
Julien Cherfils-Vicini, Charlene Iltis, +16 authors, Eric Gilson.
EMBO J, 2019 Apr 20; 38(11). PMID: 31000523    Free PMC article.
Estimation of the Percentage of US Patients With Cancer Who Are Eligible for and Respond to Checkpoint Inhibitor Immunotherapy Drugs.
Alyson Haslam, Vinay Prasad.
JAMA Netw Open, 2019 May 06; 2(5). PMID: 31050774    Free PMC article.
Highly Cited.
Two cases of intrahepatic cholangiocellular carcinoma with high insertion-deletion ratios that achieved a complete response following chemotherapy combined with PD-1 blockade.
Minghao Sui, Yu Li, +10 authors, Shichun Lu.
J Immunother Cancer, 2019 May 09; 7(1). PMID: 31064408    Free PMC article.
Molecular and pharmacological modulators of the tumor immune contexture revealed by deconvolution of RNA-seq data.
Francesca Finotello, Clemens Mayer, +20 authors, Zlatko Trajanoski.
Genome Med, 2019 May 28; 11(1). PMID: 31126321    Free PMC article.
Highly Cited.
Photoacoustic imaging as a tool to probe the tumour microenvironment.
Emma Brown, Joanna Brunker, Sarah E Bohndiek.
Dis Model Mech, 2019 Jul 25; 12(7). PMID: 31337635    Free PMC article.
Mucosal-Associated Invariant T Cells Display Diminished Effector Capacity in Oesophageal Adenocarcinoma.
Ashanty M Melo, Aisling M O'Brien, +15 authors, Margaret R Dunne.
Front Immunol, 2019 Jul 30; 10. PMID: 31354725    Free PMC article.
TGFβ blocks IFNα/β release and tumor rejection in spontaneous mammary tumors.
Marion V Guerin, Fabienne Regnier, +10 authors, Nadège Bercovici.
Nat Commun, 2019 Sep 13; 10(1). PMID: 31511510    Free PMC article.
Overexpression of the human cytomegalovirus UL111A is correlated with favorable survival of patients with gastric cancer and changes T-cell infiltration and suppresses carcinogenesis.
Xin Liu, Kangming Lin, +7 authors, Yingpeng Huang.
J Cancer Res Clin Oncol, 2020 Feb 07; 146(3). PMID: 32025866    Free PMC article.
Imaging of Activated T Cells as an Early Predictor of Immune Response to Anti-PD-1 Therapy.
Jelena Levi, Tina Lam, +10 authors, Henry VanBrocklin.
Cancer Res, 2019 May 09; 79(13). PMID: 31064845    Free PMC article.
High infiltration of mast cells is associated with improved response to adjuvant chemotherapy in gallbladder cancer.
Xiaobo Bo, Jie Wang, +12 authors, Houbao Liu.
Cancer Sci, 2020 Jan 12; 111(3). PMID: 31925976    Free PMC article.
Co-signaling receptors regulate T-cell plasticity and immune tolerance.
Haitao Shen, Na Wu, +16 authors, Xiaofeng Yang.
Front Biosci (Landmark Ed), 2018 Nov 24; 24. PMID: 30468648    Free PMC article.
Identification of immune cells and mRNA associated with prognosis of gastric cancer.
Mingming Wang, Zedong Li, +4 authors, Jun Zhou.
BMC Cancer, 2020 Mar 14; 20(1). PMID: 32164594    Free PMC article.
Tumor Infiltrating Neutrophils Are Enriched in Basal-Type Urothelial Bladder Cancer.
Giulio Eugenio Mandelli, Francesco Missale, +12 authors, William Vermi.
Cells, 2020 Jan 30; 9(2). PMID: 31991796    Free PMC article.
Monitoring Immune Responses in Neuroblastoma Patients during Therapy.
Celina L Szanto, Annelisa M Cornel, Saskia V Vijver, Stefan Nierkens.
Cancers (Basel), 2020 Feb 28; 12(2). PMID: 32102342    Free PMC article.
Characteristics of Tumor-Infiltrating Lymphocytes Prior to and During Immune Checkpoint Inhibitor Therapy.
Ioana Plesca, Antje Tunger, +6 authors, Marc Schmitz.
Front Immunol, 2020 Mar 21; 11. PMID: 32194568    Free PMC article.
Modulation of tumor microenvironment for immunotherapy: focus on nanomaterial-based strategies.
Yun Liu, Jianfeng Guo, Leaf Huang.
Theranostics, 2020 Mar 21; 10(7). PMID: 32194857    Free PMC article.
Gr-MDSC-linked asset as a potential immune biomarker in pretreated NSCLC receiving nivolumab as second-line therapy.
A Passaro, P Mancuso, +8 authors, F Bertolini.
Clin Transl Oncol, 2019 Jun 30; 22(4). PMID: 31254252
Consensus guidelines for the definition, detection and interpretation of immunogenic cell death.
Lorenzo Galluzzi, Ilio Vitale, +51 authors, Francesco M Marincola.
J Immunother Cancer, 2020 Mar 27; 8(1). PMID: 32209603    Free PMC article.
Metabolic enzymes expressed by cancer cells impact the immune infiltrate.
Gautier Stoll, Margerie Kremer, +7 authors, Guido Kroemer.
Oncoimmunology, 2019 May 10; 8(6). PMID: 31069148    Free PMC article.
Progress and Challenges in Precise Treatment of Tumors With PD-1/PD-L1 Blockade.
Youhai Jiang, Xiaofang Zhao, Jing Fu, Hongyang Wang.
Front Immunol, 2020 Apr 01; 11. PMID: 32226426    Free PMC article.
The miR-582/CD1B Axis Is Involved in Regulation of Dendritic Cells and Is Associated with Clinical Outcomes in Advanced Lung Adenocarcinoma.
Jun Guo, Hui Jin, +3 authors, Da Jiang.
Biomed Res Int, 2020 Apr 08; 2020. PMID: 32258122    Free PMC article.
Editorial: Immune Outposts on the Inflammatory Frontier: Tertiary Lymphoid Structures as Targets for Immunotherapy of Cancer and Autoimmunity.
Karina Silina, David Kroeger.
Front Immunol, 2019 May 28; 10. PMID: 31130966    Free PMC article.
Single-Cell Approaches to Profile the Response to Immune Checkpoint Inhibitors.
Lara Gibellini, Sara De Biasi, +5 authors, Andrea Cossarizza.
Front Immunol, 2020 Apr 09; 11. PMID: 32265933    Free PMC article.
Double Positive CD4+CD8+ T Cells Are Enriched in Urological Cancers and Favor T Helper-2 Polarization.
Perrine Bohner, Mathieu F Chevalier, +9 authors, Laurent Derré.
Front Immunol, 2019 Apr 16; 10. PMID: 30984190    Free PMC article.
Neoadjuvant Radiochemotherapy Significantly Alters the Phenotype of Plasmacytoid Dendritic Cells and 6-Sulfo LacNAc+ Monocytes in Rectal Cancer.
Felix Wagner, Ulrike Hölig, +20 authors, Marc Schmitz.
Front Immunol, 2019 Apr 16; 10. PMID: 30984181    Free PMC article.
The Tumor Immune Contexture of Prostate Cancer.
Natasha Vitkin, Sarah Nersesian, David Robert Siemens, Madhuri Koti.
Front Immunol, 2019 Apr 16; 10. PMID: 30984182    Free PMC article.
Immunometabolic Checkpoints of Treg Dynamics: Adaptation to Microenvironmental Opportunities and Challenges.
Ilenia Pacella, Silvia Piconese.
Front Immunol, 2019 Sep 12; 10. PMID: 31507585    Free PMC article.
Cysteine Cathepsins in Tumor-Associated Immune Cells.
Tanja Jakoš, Anja Pišlar, Anahid Jewett, Janko Kos.
Front Immunol, 2019 Sep 27; 10. PMID: 31555270    Free PMC article.
Tumor Microenvironment Characterization in Glioblastoma Identifies Prognostic and Immunotherapeutically Relevant Gene Signatures.
Jinsen Zhang, Xing Xiao, Xin Zhang, Wei Hua.
J Mol Neurosci, 2020 Feb 02; 70(5). PMID: 32006162
Tumour grade significantly correlates with total dysfunction of tumour tissue-infiltrating lymphocytes in renal cell carcinoma.
Atsunari Kawashima, Takayuki Kanazawa, +19 authors, Norio Nonomura.
Sci Rep, 2020 Apr 12; 10(1). PMID: 32277125    Free PMC article.
Immune Cytolytic Activity Is Associated With Genetic and Clinical Properties of Glioma.
Zhi-Liang Wang, Zheng Wang, +4 authors, Tao Jiang.
Front Immunol, 2019 Aug 21; 10. PMID: 31428092    Free PMC article.
Prognostic value of neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio for breast cancer patients: An updated meta-analysis of 17079 individuals.
Wanying Guo, Xin Lu, +4 authors, Miao Deng.
Cancer Med, 2019 Jun 15; 8(9). PMID: 31197958    Free PMC article.
Highly Cited.
Sphingosine-1-Phosphate and Macrophage Biology-How the Sphinx Tames the Big Eater.
Andreas Weigert, Catherine Olesch, Bernhard Brüne.
Front Immunol, 2019 Aug 06; 10. PMID: 31379883    Free PMC article.
The Remarkable Plasticity of Macrophages: A Chance to Fight Cancer.
Nadège Bercovici, Marion V Guérin, Alain Trautmann, Emmanuel Donnadieu.
Front Immunol, 2019 Jul 30; 10. PMID: 31354719    Free PMC article.
Innate immunity, inflammation and tumour progression: double-edged swords.
A Mantovani, A Ponzetta, A Inforzato, S Jaillon.
J Intern Med, 2019 Mar 16; 285(5). PMID: 30873708    Free PMC article.
Interleukin-1 and Related Cytokines in the Regulation of Inflammation and Immunity.
Alberto Mantovani, Charles A Dinarello, Martina Molgora, Cecilia Garlanda.
Immunity, 2019 Apr 18; 50(4). PMID: 30995499    Free PMC article.
Highly Cited. Review.
Tumor-infiltrating IL-17A+ cells determine favorable prognosis and adjuvant chemotherapeutic response in muscle-invasive bladder cancer.
Zewei Wang, Quan Zhou, +15 authors, Jiejie Xu.
Oncoimmunology, 2020 Apr 22; 9(1). PMID: 32313725    Free PMC article.
Tumor-associated tertiary lymphoid structure predicts postoperative outcomes in patients with primary gastrointestinal stromal tumors.
Qiaowei Lin, Ping Tao, +10 authors, Hanxing Tong.
Oncoimmunology, 2020 Apr 22; 9(1). PMID: 32313726    Free PMC article.
Resistance to PD-L1/PD-1 Blockade Immunotherapy. A Tumor-Intrinsic or Tumor-Extrinsic Phenomenon?
Luisa Chocarro de Erauso, Miren Zuazo, +8 authors, David Escors.
Front Pharmacol, 2020 Apr 23; 11. PMID: 32317979    Free PMC article.
Identification and validation of dichotomous immune subtypes based on intratumoral immune cells infiltration in clear cell renal cell carcinoma patients.
Ying Xiong, Zewei Wang, +15 authors, Jiejie Xu.
J Immunother Cancer, 2020 Mar 29; 8(1). PMID: 32217761    Free PMC article.
[Immunoncology and tumor infiltrating lymphocytes-new strategies for therapy and diagnosis of breast cancer].
Carsten Denkert.
Pathologe, 2020 Apr 05; 41(3). PMID: 32246201
A review of cancer immunotherapy: from the past, to the present, to the future.
K Esfahani, L Roudaia, +3 authors, W H Miller.
Curr Oncol, 2020 May 06; 27(Suppl 2). PMID: 32368178    Free PMC article.
Perineural Invasion and Postoperative Adjuvant Chemotherapy Efficacy in Patients With Gastric Cancer.
Qing Tao, Wen Zhu, +4 authors, Xiaoqin Li.
Front Oncol, 2020 May 07; 10. PMID: 32373527    Free PMC article.
High-dimensional analyses reveal a distinct role of T-cell subsets in the immune microenvironment of gastric cancer.
Minyu Wang, Yu-Kuan Huang, +14 authors, Alex Boussioutas.
Clin Transl Immunology, 2020 May 08; 9(5). PMID: 32377339    Free PMC article.
Distinct prognostic value of circulating anti-telomerase CD4+ Th1 immunity and exhausted PD-1+/TIM-3+ T cells in lung cancer.
Caroline Laheurte, Magalie Dosset, +14 authors, Olivier Adotévi.
Br J Cancer, 2019 Jul 31; 121(5). PMID: 31358938    Free PMC article.
Inhibition of transcription by dactinomycin reveals a new characteristic of immunogenic cell stress.
Juliette Humeau, Allan Sauvat, +12 authors, Guido Kroemer.
EMBO Mol Med, 2020 Apr 24; 12(5). PMID: 32323922    Free PMC article.
Intrinsic Genetic and Transcriptomic Patterns Reflect Tumor Immune Subtypes Facilitating Exploring Possible Combinatory Therapy.
Yong Xu, Daixi Li, +3 authors, Guangrong Qin.
Front Mol Biosci, 2020 May 12; 7. PMID: 32391377    Free PMC article.
Oligoprogressive Non-Small-Cell Lung Cancer under Treatment with PD-(L)1 Inhibitors.
Stephan Rheinheimer, Claus-Peter Heussel, +13 authors, Petros Christopoulos.
Cancers (Basel), 2020 Apr 29; 12(4). PMID: 32340408    Free PMC article.
Why is cancer not more common? A changing microenvironment may help to explain why, and suggests strategies for anti-cancer therapy.
Xiaowei Jiang, Ian P M Tomlinson.
Open Biol, 2020 Apr 15; 10(4). PMID: 32289242    Free PMC article.
Long Non-coding RNA LINC02195 as a Regulator of MHC I Molecules and Favorable Prognostic Marker for Head and Neck Squamous Cell Carcinoma.
Hao Li, Hong-Gang Xiong, +5 authors, Zhi-Jun Sun.
Front Oncol, 2020 May 22; 10. PMID: 32435615    Free PMC article.
Going to extremes: determinants of extraordinary response and survival in patients with cancer.
Flurina A M Saner, Alan Herschtal, +13 authors, David D L Bowtell.
Nat Rev Cancer, 2019 May 12; 19(6). PMID: 31076661    Free PMC article.
The Tumor Microenvironment in the Response to Immune Checkpoint Blockade Therapies.
Florent Petitprez, Maxime Meylan, +2 authors, Wolf H Fridman.
Front Immunol, 2020 May 28; 11. PMID: 32457745    Free PMC article.
Immunoscore Predicts Survival in Early-Stage Lung Adenocarcinoma Patients.
Zihuan Zhao, Dan Zhao, +2 authors, Buhai Wang.
Front Oncol, 2020 May 28; 10. PMID: 32457841    Free PMC article.
Relevance of immune cell and tumor microenvironment imaging in the new era of immunotherapy.
Filippo Galli, Jesus Vera Aguilera, +3 authors, Alberto Signore.
J Exp Clin Cancer Res, 2020 May 20; 39(1). PMID: 32423420    Free PMC article.
Natural killer cell and stroma abundance are independently prognostic and predict gastric cancer chemotherapy benefit.
Bailiang Li, Yuming Jiang, +2 authors, Ruijiang Li.
JCI Insight, 2020 Apr 02; 5(9). PMID: 32229725    Free PMC article.
Injectable Therapies for Regional Melanoma.
Norma E Farrow, Margaret Leddy, Karenia Landa, Georgia M Beasley.
Surg Oncol Clin N Am, 2020 Jun 03; 29(3). PMID: 32482318    Free PMC article.
Growth/Differentiation Factor-15 (GDF-15): From Biomarker to Novel Targetable Immune Checkpoint.
Jörg Wischhusen, Ignacio Melero, Wolf Herman Fridman.
Front Immunol, 2020 Jun 09; 11. PMID: 32508832    Free PMC article.
Influence of Innate Immunity on Cancer Cell Stemness.
Anna Pastò, Francesca Maria Consonni, Antonio Sica.
Int J Mol Sci, 2020 May 14; 21(9). PMID: 32397392    Free PMC article.
A four-factor immune risk score signature predicts the clinical outcome of patients with spinal chordoma.
Ming-Xiang Zou, Yue Pan, +7 authors, Jing Li.
Clin Transl Med, 2020 Jun 09; 10(1). PMID: 32508056    Free PMC article.
Infiltration of CD8+ FOXP3+ T cells, CD8+ T cells, and FOXP3+ T cells in non-small cell lung cancer microenvironment.
Jianqing Hao, Helin Wang, +5 authors, Jinghui Wang.
Int J Clin Exp Pathol, 2020 Jun 09; 13(5). PMID: 32509058    Free PMC article.
Racial differences in CD8+ T cell infiltration in breast tumors from Black and White women.
Yara Abdou, Kristopher Attwood, +9 authors, Angela R Omilian.
Breast Cancer Res, 2020 Jun 11; 22(1). PMID: 32517730    Free PMC article.
Prognostic value of the systemic immune-inflammation index in patients with breast cancer: a meta-analysis.
Yantao Zhang, Yong Sun, Qiwen Zhang.
Cancer Cell Int, 2020 Jun 13; 20. PMID: 32528232    Free PMC article.
Tumor microenvironment characterization identifies two lung adenocarcinoma subtypes with specific immune and metabolic state.
Jianbing Huang, Jiagen Li, +10 authors, Jie He.
Cancer Sci, 2020 Mar 19; 111(6). PMID: 32187778    Free PMC article.
Combining measures of immune infiltration shows additive effect on survival prediction in high-grade serous ovarian carcinoma.
Anne Montfort, Stephanie Owen, +8 authors, James D Brenton.
Br J Cancer, 2020 Apr 07; 122(12). PMID: 32249277    Free PMC article.
Emerging role of PTEN loss in evasion of the immune response to tumours.
Thiago Vidotto, Camila Morais Melo, +3 authors, Jeremy A Squire.
Br J Cancer, 2020 Apr 25; 122(12). PMID: 32327707    Free PMC article.
Stromal LAG-3+ cells infiltration defines poor prognosis subtype muscle-invasive bladder cancer with immunoevasive contexture.
Han Zeng, Quan Zhou, +14 authors, Jiejie Xu.
J Immunother Cancer, 2020 Jun 17; 8(1). PMID: 32540859    Free PMC article.
Lessons from Hippocrates: Time to Change the Cancer Paradigm.
Carlos M Galmarini.
Int J Chronic Dis, 2020 Jun 23; 2020. PMID: 32566644    Free PMC article.
Immune-infiltration based signature as a novel prognostic biomarker in gastrointestinal stromal tumour.
Zhe-Wei Wei, Jing Wu, +8 authors, Chang-Hua Zhang.
EBioMedicine, 2020 Jun 24; 57. PMID: 32574962    Free PMC article.
Immune profiling of pediatric solid tumors.
Rachael L Terry, Deborah Meyran, +4 authors, Paul J Neeson.
J Clin Invest, 2020 Jun 17; 130(7). PMID: 32538896    Free PMC article.
Nine-factor-based immunohistochemistry classifier predicts recurrence for early-stage hepatocellular carcinoma after curative resection.
Wei-Ren Liu, Meng-Xin Tian, +13 authors, Ying-Hong Shi.
Br J Cancer, 2020 May 08; 123(1). PMID: 32376890    Free PMC article.
Tumor microenvironment characterization in head and neck cancer identifies prognostic and immunotherapeutically relevant gene signatures.
Mengqi Huo, Ying Zhang, +3 authors, Tianke Li.
Sci Rep, 2020 Jul 09; 10(1). PMID: 32636465    Free PMC article.
Characterising the prognostic potential of HLA-DR during colorectal cancer development.
Margaret R Dunne, James J Phelan, +10 authors, Jacintha O'Sullivan.
Cancer Immunol Immunother, 2020 Apr 20; 69(8). PMID: 32306077    Free PMC article.
Prevalence of PD-L1 expression is associated with EMAST, density of peritumoral T-cells and recurrence-free survival in operable non-metastatic colorectal cancer.
Martin M Watson, Dordi Lea, +3 authors, Kjetil Søreide.
Cancer Immunol Immunother, 2020 Apr 22; 69(8). PMID: 32314040    Free PMC article.
The Role of Tumor-Associated Myeloid Cells in Modulating Cancer Therapy.
Christiana M Neophytou, Chryso Pierides, +3 authors, Panagiotis Papageorgis.
Front Oncol, 2020 Jul 14; 10. PMID: 32656079    Free PMC article.
Combined PARP Inhibition and Immune Checkpoint Therapy in Solid Tumors.
Florent Peyraud, Antoine Italiano.
Cancers (Basel), 2020 Jun 13; 12(6). PMID: 32526888    Free PMC article.
Innate Immune Cells and Their Contribution to T-Cell-Based Immunotherapy.
Pierpaolo Ginefra, Girieca Lorusso, Nicola Vannini.
Int J Mol Sci, 2020 Jun 26; 21(12). PMID: 32580431    Free PMC article.
A Seven-Gene Signature with Close Immune Correlation Was Identified for Survival Prediction of Lung Adenocarcinoma.
Xuan Zou, Zhihuang Hu, Changjing Huang, Jianhua Chang.
Med Sci Monit, 2020 Jul 03; 26. PMID: 32613949    Free PMC article.
Toward Systems Biomarkers of Response to Immune Checkpoint Blockers.
Óscar Lapuente-Santana, Federica Eduati.
Front Oncol, 2020 Jul 17; 10. PMID: 32670886    Free PMC article.
Characterization of a Myeloid Activation Signature that Correlates with Survival in Melanoma Patients.
Mirela Kremenovic, Nives Rombini, +4 authors, Mirjam Schenk.
Cancers (Basel), 2020 Jun 04; 12(6). PMID: 32486450    Free PMC article.
Integrating the Tumor Microenvironment into Cancer Therapy.
Sabina Sanegre, Federico Lucantoni, +3 authors, Tomás Álvaro Naranjo.
Cancers (Basel), 2020 Jul 01; 12(6). PMID: 32599891    Free PMC article.
Telomerase and CD4 T Cell Immunity in Cancer.
Magalie Dosset, Andrea Castro, Hannah Carter, Maurizio Zanetti.
Cancers (Basel), 2020 Jul 08; 12(6). PMID: 32630460    Free PMC article.
Could Protons and Carbon Ions Be the Silver Bullets Against Pancreatic Cancer?
Camille Huart, Jia-Wei Chen, +2 authors, Anne-Catherine Wéra.
Int J Mol Sci, 2020 Jul 09; 21(13). PMID: 32635552    Free PMC article.
CD8+ Tumour-Infiltrating Lymphocytes and Tumour Microenvironment Immune Types as Biomarkers for Immunotherapy in Sinonasal Intestinal-Type Adenocarcinoma.
Rocío García-Marín, Sara Reda, +6 authors, Mario A Hermsen.
Vaccines (Basel), 2020 May 02; 8(2). PMID: 32353928    Free PMC article.
Heterogeneity of Glucose Transport in Lung Cancer.
Cesar A Martinez, Claudio Scafoglio.
Biomolecules, 2020 Jun 11; 10(6). PMID: 32517099    Free PMC article.
AXL Targeting Abrogates Autophagic Flux and Induces Immunogenic Cell Death in Drug-Resistant Cancer Cells.
Maria L Lotsberg, Katarzyna Wnuk-Lipinska, +22 authors, Agnete Svendsen Tenfjord Engelsen.
J Thorac Oncol, 2020 Feb 06; 15(6). PMID: 32018052    Free PMC article.
Lymphocyte activation gene-3 (LAG3) mRNA and protein expression on tumour infiltrating lymphocytes (TILs) in oesophageal adenocarcinoma.
Florian Gebauer, Max Krämer, +9 authors, Alexander Quaas.
J Cancer Res Clin Oncol, 2020 Jun 28; 146(9). PMID: 32592066    Free PMC article.
Glucometabolic Reprogramming in the Hepatocellular Carcinoma Microenvironment: Cause and Effect.
Huining Tian, Xiaoyu Zhu, +2 authors, Guixia Wang.
Cancer Manag Res, 2020 Aug 09; 12. PMID: 32765096    Free PMC article.
Immune Cell Infiltration and Identifying Genes of Prognostic Value in the Papillary Renal Cell Carcinoma Microenvironment by Bioinformatics Analysis.
Ting Liu, Man Zhang, Deming Sun.
Biomed Res Int, 2020 Aug 11; 2020. PMID: 32775427    Free PMC article.
Deconvolution of the immunological contexture of mouse tumors with multiplexed immunohistochemistry.
Ileana S Mauldin, Natasha D Sheybani, +2 authors, Craig L Slingluff.
Methods Enzymol, 2020 Mar 04; 635. PMID: 32122555    Free PMC article.
Large-scale transcriptome profiles reveal robust 20-signatures metabolic prediction models and novel role of G6PC in clear cell renal cell carcinoma.
Wen-Hao Xu, Yue Xu, +10 authors, Ding-Wei Ye.
J Cell Mol Med, 2020 Jun 23; 24(16). PMID: 32567187    Free PMC article.
Combinatorial Immunotherapies for Metastatic Colorectal Cancer.
Eline Janssen, Beatriz Subtil, +2 authors, Daniele V F Tauriello.
Cancers (Basel), 2020 Jul 16; 12(7). PMID: 32664619    Free PMC article.
Modulation of Determinant Factors to Improve Therapeutic Combinations with Immune Checkpoint Inhibitors.
Magalie Dosset, Elodie Lauret-Marie Joseph, Thaiz Rivera Vargas, Lionel Apetoh.
Cells, 2020 Jul 28; 9(7). PMID: 32707692    Free PMC article.
Myeloid Cells as Clinical Biomarkers for Immune Checkpoint Blockade.
Elisa Peranzoni, Vincenzo Ingangi, +2 authors, Ilaria Marigo.
Front Immunol, 2020 Aug 15; 11. PMID: 32793228    Free PMC article.
Identification of Immune-Related Prognostic Genes and LncRNAs Biomarkers Associated With Osteosarcoma Microenvironment.
Tao Zhang, Yingli Nie, +5 authors, Jiliang Wang.
Front Oncol, 2020 Aug 15; 10. PMID: 32793475    Free PMC article.
Unraveling the Complexity of the Cancer Microenvironment With Multidimensional Genomic and Cytometric Technologies.
Natasja L de Vries, Ahmed Mahfouz, Frits Koning, Noel F C C de Miranda.
Front Oncol, 2020 Aug 15; 10. PMID: 32793500    Free PMC article.
Bone metastasis is associated with acquisition of mesenchymal phenotype and immune suppression in a model of spontaneous breast cancer metastasis.
Lea Monteran, Nour Ershaid, +7 authors, Neta Erez.
Sci Rep, 2020 Aug 17; 10(1). PMID: 32796899    Free PMC article.
Intratumoral TIGIT+ CD8+ T-cell infiltration determines poor prognosis and immune evasion in patients with muscle-invasive bladder cancer.
Zhaopei Liu, Quan Zhou, +19 authors, Weijuan Zhang.
J Immunother Cancer, 2020 Aug 21; 8(2). PMID: 32817209    Free PMC article.
Preclinical and Clinical Immunotherapeutic Strategies in Epithelial Ovarian Cancer.
Alejandra Martinez, Jean-Pierre Delord, Maha Ayyoub, Christel Devaud.
Cancers (Basel), 2020 Jul 08; 12(7). PMID: 32630708    Free PMC article.
Immune Landscape in Tumor Microenvironment: Implications for Biomarker Development and Immunotherapy.
Karim Pérez-Romero, Ramón M Rodríguez, +2 authors, Daniel H Lopez.
Int J Mol Sci, 2020 Aug 06; 21(15). PMID: 32752264    Free PMC article.
M2-like macrophages dictate clinically relevant immunosuppression in metastatic ovarian cancer.
Michal Hensler, Lenka Kasikova, +22 authors, Jitka Fucikova.
J Immunother Cancer, 2020 Aug 21; 8(2). PMID: 32819974    Free PMC article.
Myeloid signature reveals immune contexture and predicts the prognosis of hepatocellular carcinoma.
Chong Wu, Jie Lin, +17 authors, Limin Zheng.
J Clin Invest, 2020 Jun 05; 130(9). PMID: 32497024    Free PMC article.
Distinct tumor immune microenvironments in primary and metastatic lesions in gastric cancer patients.
Seung-Myoung Son, Chang Gok Woo, +12 authors, Hye Sook Han.
Sci Rep, 2020 Sep 02; 10(1). PMID: 32868848    Free PMC article.
Prognostic Value of Immune Environment Analysis in Small Bowel Adenocarcinomas with Verified Mutational Landscape and Predisposing Conditions.
Erkki-Ville Wirta, Säde Szeto, +5 authors, Toni T Seppälä.
Cancers (Basel), 2020 Jul 29; 12(8). PMID: 32718028    Free PMC article.
Molecular and Cellular Factors Associated with Racial Disparity in Breast Cancer.
Manish Charan, Ajeet K Verma, +6 authors, Ramesh K Ganju.
Int J Mol Sci, 2020 Aug 23; 21(16). PMID: 32824813    Free PMC article.
Immune infiltrating cells in duodenal cancers.
G Donisi, G Capretti, +8 authors, F Marchesi.
J Transl Med, 2020 Sep 05; 18(1). PMID: 32883314    Free PMC article.
Lack of myeloid cell infiltration as an acquired resistance strategy to immunotherapy.
Elham Beyranvand Nejad, Camilla Labrie, +12 authors, Sjoerd H van der Burg.
J Immunother Cancer, 2020 Sep 03; 8(2). PMID: 32873723    Free PMC article.
Inflammation and lymphocyte infiltration are associated with shorter survival in patients with high-grade glioma.
Eliana Marinari, Mathilde Allard, +6 authors, Pierre-Yves Dietrich.
Oncoimmunology, 2020 Sep 15; 9(1). PMID: 32923142    Free PMC article.
Contribution of annexin A1 to anticancer immunosurveillance.
Elisa Elena Baracco, Gautier Stoll, +3 authors, Guido Kroemer.
Oncoimmunology, 2020 Sep 15; 8(11). PMID: 32923172    Free PMC article.
Overcoming immunotherapy resistance in non-small cell lung cancer (NSCLC) - novel approaches and future outlook.
Lena Horvath, Bernard Thienpont, +2 authors, Andreas Pircher.
Mol Cancer, 2020 Sep 13; 19(1). PMID: 32917214    Free PMC article.
MMP2 as an independent prognostic stratifier in oral cavity cancers.
Caroline Hoffmann, Sophie Vacher, +16 authors, Vassili Soumelis.
Oncoimmunology, 2020 Sep 17; 9(1). PMID: 32934875    Free PMC article.
Trial watch: TLR3 agonists in cancer therapy.
Julie Le Naour, Lorenzo Galluzzi, +2 authors, Erika Vacchelli.
Oncoimmunology, 2020 Sep 17; 9(1). PMID: 32934877    Free PMC article.
Trial watch: STING agonists in cancer therapy.
Julie Le Naour, Laurence Zitvogel, +2 authors, Guido Kroemer.
Oncoimmunology, 2020 Sep 17; 9(1). PMID: 32934881    Free PMC article.
Trial watch: IDO inhibitors in cancer therapy.
Julie Le Naour, Lorenzo Galluzzi, +2 authors, Erika Vacchelli.
Oncoimmunology, 2020 Sep 17; 9(1). PMID: 32934882    Free PMC article.
Interplay of somatic alterations and immune infiltration modulates response to PD-1 blockade in advanced clear cell renal cell carcinoma.
David A Braun, Yue Hou, +23 authors, Toni K Choueiri.
Nat Med, 2020 May 31; 26(6). PMID: 32472114    Free PMC article.
Classification of Muscle-Invasive Bladder Cancer Based on Immunogenomic Profiling.
Xianghong Zhou, Shi Qiu, +5 authors, Qiang Wei.
Front Oncol, 2020 Sep 26; 10. PMID: 32974156    Free PMC article.
One Health, Fermented Foods, and Gut Microbiota.
Victoria Bell, Jorge Ferrão, +2 authors, Tito Fernandes.
Foods, 2018 Dec 06; 7(12). PMID: 30513869    Free PMC article.
Data-Driven Discovery of Immune Contexture Biomarkers.
Lars Ole Schwen, Emilia Andersson, +6 authors, Oliver Grimm.
Front Oncol, 2019 Jan 09; 8. PMID: 30619761    Free PMC article.
PD-L2 expression is correlated with the molecular and clinical features of glioma, and acts as an unfavorable prognostic factor.
Zhi-Liang Wang, Guan-Zhang Li, +4 authors, Tao Jiang.
Oncoimmunology, 2019 Feb 05; 8(2). PMID: 30713802    Free PMC article.
Tumor-infiltrating T cells and PD-L1 expression in childhood malignant extracranial germ-cell tumors.
Renata Boldrini, Maria Debora De Pasquale, +11 authors, Doriana Fruci.
Oncoimmunology, 2019 Feb 05; 8(2). PMID: 30713803    Free PMC article.
The Interplay of Autophagy and Tumor Microenvironment in Colorectal Cancer-Ways of Enhancing Immunotherapy Action.
Evangelos Koustas, Panagiotis Sarantis, +2 authors, Michalis V Karamouzis.
Cancers (Basel), 2019 Apr 25; 11(4). PMID: 31013961    Free PMC article.
Identification of a RIP1 Kinase Inhibitor Clinical Candidate (GSK3145095) for the Treatment of Pancreatic Cancer.
Philip A Harris, Jill M Marinis, +25 authors, Robert W Marquis.
ACS Med Chem Lett, 2019 Jun 22; 10(6). PMID: 31223438    Free PMC article.
Physical Activity and Colorectal Cancer Prognosis According to Tumor-Infiltrating T Cells.
Hideo Koh, Tsuyoshi Hamada, +28 authors, Shuji Ogino.
JNCI Cancer Spectr, 2019 Jul 06; 2(4). PMID: 31276098    Free PMC article.
Advances in Molecular Mechanisms and Immunotherapy Involving the Immune Cell-Promoted Epithelial-to-Mesenchymal Transition in Lung Cancer.
Serena De Matteis, Matteo Canale, +5 authors, Paola Ulivi.
J Oncol, 2019 Sep 19; 2019. PMID: 31531020    Free PMC article.
Immune landscape and biomarkers for immuno-oncology in colorectal cancers.
Jeong Mo Bae, Seung-Yeon Yoo, Jung Ho Kim, Gyeong Hoon Kang.
J Pathol Transl Med, 2020 Jun 26; 54(5). PMID: 32580539    Free PMC article.
Coordinated Cellular Neighborhoods Orchestrate Antitumoral Immunity at the Colorectal Cancer Invasive Front.
Christian M Schürch, Salil S Bhate, +11 authors, Garry P Nolan.
Cell, 2020 Aug 09; 182(5). PMID: 32763154    Free PMC article.
The prognostic and predictive role of the neutrophil-to-lymphocyte ratio and the monocyte-to-lymphocyte ratio in early breast cancer, especially in the HER2+ subtype.
Satu Tiainen, Kirsi Rilla, +2 authors, Päivi Auvinen.
Breast Cancer Res Treat, 2020 Sep 20; 185(1). PMID: 32948994    Free PMC article.
The complexity of neutrophils in health and disease: Focus on cancer.
Silvia Carnevale, Somayehsadat Ghasemi, Anna Rigatelli, Sebastien Jaillon.
Semin Immunol, 2020 Sep 23; 48. PMID: 32958359    Free PMC article.
IL-32γ potentiates tumor immunity in melanoma.
Thomas Gruber, Mirela Kremenovic, +12 authors, Mirjam Schenk.
JCI Insight, 2020 Aug 26; 5(18). PMID: 32841222    Free PMC article.
TCR Redirected T Cells for Cancer Treatment: Achievements, Hurdles, and Goals.
Francesco Manfredi, Beatrice Claudia Cianciotti, +6 authors, Eliana Ruggiero.
Front Immunol, 2020 Oct 06; 11. PMID: 33013822    Free PMC article.
Tumor-Infiltrating Lymphocytes and Their Prognostic Value in Cutaneous Melanoma.
Fabienne Maibach, Hassan Sadozai, +2 authors, Mirjam Schenk.
Front Immunol, 2020 Oct 06; 11. PMID: 33013886    Free PMC article.
Regulation of tumor growth by leukocyte-specific protein 1 in T cells.
Riri Kwon, Bong-Ki Hong, +5 authors, Wan-Uk Kim.
J Immunother Cancer, 2020 Oct 07; 8(2). PMID: 33020243    Free PMC article.
The murine Microenvironment Cell Population counter method to estimate abundance of tissue-infiltrating immune and stromal cell populations in murine samples using gene expression.
Florent Petitprez, Sacha Levy, +10 authors, Aurélien de Reyniès.
Genome Med, 2020 Oct 08; 12(1). PMID: 33023656    Free PMC article.
A pre-existing coordinated inflammatory microenvironment is associated with complete response of vulvar high-grade squamous intraepithelial lesions to different forms of immunotherapy.
Ziena Abdulrahman, Noel F C C de Miranda, +4 authors, Mariette I E van Poelgeest.
Int J Cancer, 2020 Jun 24; 147(10). PMID: 32574376    Free PMC article.
Identification and validation of an immune-related gene-based prognostic index for bladder cancer.
Zijian Tian, Lingfeng Meng, +5 authors, Jianye Wang.
Am J Transl Res, 2020 Oct 13; 12(9). PMID: 33042413    Free PMC article.
Association between lactate dehydrogenase levels and oncologic outcomes in metastatic prostate cancer: A meta-analysis.
Fan Li, Hui Xiang, +5 authors, Tianyu Zhang.
Cancer Med, 2020 May 27; 9(19). PMID: 32452656    Free PMC article.
A purified membrane protein from Akkermansia muciniphila or the pasteurised bacterium blunts colitis associated tumourigenesis by modulation of CD8+ T cells in mice.
Lijuan Wang, Lei Tang, +9 authors, Zhan Zhang.
Gut, 2020 Mar 15; 69(11). PMID: 32169907    Free PMC article.
Clinical impact of combined epigenetic and molecular analysis of pediatric low-grade gliomas.
Kohei Fukuoka, Yasin Mamatjan, +29 authors, Uri Tabori.
Neuro Oncol, 2020 Apr 04; 22(10). PMID: 32242226    Free PMC article.
Comprehensive Study of Tumor Immune Microenvironment and Relevant Genes in Hepatocellular Carcinoma Identifies Potential Prognostic Significance.
Wenbiao Chen, Xujun Zhang, +4 authors, Hongyan Diao.
Front Oncol, 2020 Oct 20; 10. PMID: 33072579    Free PMC article.
Prognostic and Predictive Value of Tumor-Infiltrating Immune Cells in Urothelial Cancer of the Bladder.
Sandra van Wilpe, Eveline C F Gerretsen, +3 authors, Niven Mehra.
Cancers (Basel), 2020 Sep 25; 12(9). PMID: 32967190    Free PMC article.
Expression of TAM-R in Human Immune Cells and Unique Regulatory Function of MerTK in IL-10 Production by Tolerogenic DC.
Paul Giroud, Sarah Renaudineau, +7 authors, Jenny Valladeau-Guilemond.
Front Immunol, 2020 Oct 27; 11. PMID: 33101282    Free PMC article.
Immune Escape Mechanisms and Their Clinical Relevance in Head and Neck Squamous Cell Carcinoma.
Barbara Seliger, Chiara Massa, +4 authors, Claudia Wickenhauser.
Int J Mol Sci, 2020 Sep 30; 21(19). PMID: 32987799    Free PMC article.
Breast cancer cell debris diminishes therapeutic efficacy through heme oxygenase-1-mediated inactivation of M1-like tumor-associated macrophages.
Seung Hyeon Kim, Soma Saeidi, +10 authors, Young-Joon Surh.
Neoplasia, 2020 Oct 12; 22(11). PMID: 33039895    Free PMC article.
Combining multiple spatial statistics enhances the description of immune cell localisation within tumours.
Joshua A Bull, Philip S Macklin, +4 authors, Helen M Byrne.
Sci Rep, 2020 Oct 31; 10(1). PMID: 33122646    Free PMC article.
Selective SIRPα blockade reverses tumor T cell exclusion and overcomes cancer immunotherapy resistance.
Vanessa Gauttier, Sabrina Pengam, +40 authors, Nicolas Poirier.
J Clin Invest, 2020 Oct 20; 130(11). PMID: 33074246    Free PMC article.
Heat Shock Protein 90 Family Isoforms as Prognostic Biomarkers and Their Correlations with Immune Infiltration in Breast Cancer.
Tong Lin, Yuqin Qiu, Wenya Peng, Lisheng Peng.
Biomed Res Int, 2020 Nov 05; 2020. PMID: 33145341    Free PMC article.
Innate Immune Training of Granulopoiesis Promotes Anti-tumor Activity.
Lydia Kalafati, Ioannis Kourtzelis, +27 authors, Triantafyllos Chavakis.
Cell, 2020 Oct 31; 183(3). PMID: 33125892    Free PMC article.
Reprogramming the tumour microenvironment by radiotherapy: implications for radiotherapy and immunotherapy combinations.
Madyson Colton, Eleanor J Cheadle, Jamie Honeychurch, Tim M Illidge.
Radiat Oncol, 2020 Nov 06; 15(1). PMID: 33148287    Free PMC article.
Tackling TAMs for Cancer Immunotherapy: It's Nano Time.
Yishun Yang, Jianfeng Guo, Leaf Huang.
Trends Pharmacol Sci, 2020 Sep 19; 41(10). PMID: 32946772    Free PMC article.
Manipulation of Glucose Availability to Boost Cancer Immunotherapies.
Federica Marchesi, Debora Vignali, +2 authors, Paolo Monti.
Cancers (Basel), 2020 Oct 16; 12(10). PMID: 33053779    Free PMC article.
Macrophage morphology correlates with single-cell diversity and prognosis in colorectal liver metastasis.
Matteo Donadon, Guido Torzilli, +16 authors, Federica Marchesi.
J Exp Med, 2020 Aug 14; 217(11). PMID: 32785653    Free PMC article.
The biologically functional identification of a novel TIM3-binding peptide P26 in vitro and in vivo.
Tangwu Zhong, Chuanke Zhao, +3 authors, Chengchao Shou.
Cancer Chemother Pharmacol, 2020 Oct 22; 86(6). PMID: 33084973    Free PMC article.
Tumor-infiltrating TNFRSF9+ CD8+ T cells define different subsets of clear cell renal cell carcinoma with prognosis and immunotherapeutic response.
Yaohui Li, Zewei Wang, +15 authors, Jiejie Xu.
Oncoimmunology, 2020 Nov 13; 9(1). PMID: 33178496    Free PMC article.
Custom-designed Small Animal focal iRradiation Jig (SARJ): design, manufacture and dosimetric evaluation.
Jothy Selvaraj, Graham Rhall, +7 authors, Ben J C Quah.
BJR Open, 2020 Nov 13; 2(1). PMID: 33178966    Free PMC article.
Study and analysis of antitumor resistance mechanism of PD1/PD-L1 immune checkpoint blocker.
Zhengyi Wang, Xiaoying Wu.
Cancer Med, 2020 Sep 03; 9(21). PMID: 32875727    Free PMC article.
Rate differences between first and second primary cancers may outline immune dysfunction as a key risk factor.
Guoqiao Zheng, Kristina Sundquist, +3 authors, Kari Hemminki.
Cancer Med, 2020 Sep 23; 9(21). PMID: 32960498    Free PMC article.
Metformin changes the immune microenvironment of colorectal cancer in patients with type 2 diabetes mellitus.
Akira Saito, Joji Kitayama, +7 authors, Naohiro Sata.
Cancer Sci, 2020 Aug 15; 111(11). PMID: 32794612    Free PMC article.
Prognostic significance of tumor-infiltrating immune cells in muscle-invasive bladder cancer.
Yu-Lu Peng, Ze-Shen Wu, +10 authors, Fang-Jian Zhou.
Am J Transl Res, 2020 Nov 17; 12(10). PMID: 33194049    Free PMC article.
The Resistance Mechanisms of Lung Cancer Immunotherapy.
Fen Wang, Shubin Wang, Qing Zhou.
Front Oncol, 2020 Nov 17; 10. PMID: 33194652    Free PMC article.
Combining Qdot Nanotechnology and DNA Nanotechnology for Sensitive Single-Cell Imaging.
Wen Zhou, Yan Han, Brian J Beliveau, Xiaohu Gao.
Adv Mater, 2020 Jun 17; 32(30). PMID: 32542832    Free PMC article.
New insights into the interaction of the immune system with non-small cell lung carcinomas.
Paul Hofman.
Transl Lung Cancer Res, 2020 Nov 20; 9(5). PMID: 33209644    Free PMC article.
Immune-related lncRNAs as predictors of survival in breast cancer: a prognostic signature.
Wei Ma, Fangkun Zhao, +7 authors, Feng Jin.
J Transl Med, 2020 Nov 24; 18(1). PMID: 33225954    Free PMC article.
Tumor-associated macrophage, angiogenesis and lymphangiogenesis markers predict prognosis of non-small cell lung cancer patients.
Ilseon Hwang, Jeong Won Kim, +7 authors, Stephen M Hewitt.
J Transl Med, 2020 Nov 25; 18(1). PMID: 33228719    Free PMC article.
Tumor-infiltrating podoplanin+ cells in gastric cancer: clinical outcomes and association with immune contexture.
Xin Liu, Yifan Cao, +13 authors, Heng Zhang.
Oncoimmunology, 2020 Nov 26; 9(1). PMID: 33235820    Free PMC article.
Definition and review on a category of long non-coding RNA: Atherosclerosis-associated circulating lncRNA (ASCLncRNA).
Shanshan Lu, Qin Liang, +2 authors, Junwen Liu.
PeerJ, 2020 Nov 27; 8. PMID: 33240586    Free PMC article.
The Immune Checkpoint PD-1 in Natural Killer Cells: Expression, Function and Targeting in Tumour Immunotherapy.
Linda Quatrini, Francesca Romana Mariotti, +3 authors, Lorenzo Moretta.
Cancers (Basel), 2020 Nov 12; 12(11). PMID: 33172030    Free PMC article.
The Angiopoietin-2 and TIE Pathway as a Therapeutic Target for Enhancing Antiangiogenic Therapy and Immunotherapy in Patients with Advanced Cancer.
Alessandra Leong, Minah Kim.
Int J Mol Sci, 2020 Nov 22; 21(22). PMID: 33217955    Free PMC article.
Investigation of the prognostic value of CD4 T cell subsets expanded from tumor-infiltrating lymphocytes of colorectal cancer liver metastases.
Marie Kroemer, Celia Turco, +12 authors, Christophe Borg.
J Immunother Cancer, 2020 Nov 25; 8(2). PMID: 33229508    Free PMC article.
Multitasking discoidin domain receptors are involved in several and specific hallmarks of cancer.
Elodie Henriet, Margaux Sala, +4 authors, Frédéric Saltel.
Cell Adh Migr, 2018 Apr 28; 12(4). PMID: 29701112    Free PMC article.
Tumour heterogeneity and metastasis at single-cell resolution.
Devon A Lawson, Kai Kessenbrock, +2 authors, Zena Werb.
Nat Cell Biol, 2018 Nov 30; 20(12). PMID: 30482943    Free PMC article.
Highly Cited. Review.
The lung microenvironment: an important regulator of tumour growth and metastasis.
Nasser K Altorki, Geoffrey J Markowitz, +5 authors, Vivek Mittal.
Nat Rev Cancer, 2018 Dec 12; 19(1). PMID: 30532012    Free PMC article.
Highly Cited. Review.
Integrating histopathology, immune biomarkers, and molecular subgroups in solid cancer: the next step in precision oncology.
Nicolas A Giraldo, J David Peske, Catherine Sautès-Fridman, Wolf H Fridman.
Virchows Arch, 2019 Jan 12; 474(4). PMID: 30631935
Time for radioimmunotherapy: an overview to bring improvements in clinical practice.
O Leaman Alcibar, D Candini, +9 authors, M E Rodríguez-Ruiz.
Clin Transl Oncol, 2019 Jan 16; 21(8). PMID: 30644044
2020 vision or myopia? A personal perspective on the future of cancer imaging and an introduction to the sequels to the "How I Read Series".
Rodney J Hicks.
Cancer Imaging, 2019 Feb 08; 19(1). PMID: 30728071    Free PMC article.
Implementation of Mass Cytometry for Immunoprofiling of Patients with Solid Tumors.
Ingrid Poláková, Ondřej Pelák, +4 authors, Michal Šmahel.
J Immunol Res, 2019 Mar 20; 2019. PMID: 30886872    Free PMC article.
Immune contexture defined by single cell technology for prognosis prediction and immunotherapy guidance in cancer.
Tong Wu, Xuan Wu, Hong-Yang Wang, Lei Chen.
Cancer Commun (Lond), 2019 Apr 20; 39(1). PMID: 30999966    Free PMC article.
Activation of RIG-I signaling to increase the pro-inflammatory phenotype of a tumor.
David L Elion, Rebecca S Cook.
Oncotarget, 2019 May 02; 10(24). PMID: 31040925    Free PMC article.
Prognostic impact of p16 and PD-L1 expression in patients with oropharyngeal squamous cell carcinoma receiving a definitive treatment.
Fumihiko Sato, Takeharu Ono, +7 authors, Hirohisa Yano.
J Clin Pathol, 2019 May 23; 72(8). PMID: 31113825    Free PMC article.
PD-1 high expression predicts lower local disease control in stage IV M0 nasopharyngeal carcinoma.
Feng Jiang, Wei Yu, +7 authors, Qichun Wei.
BMC Cancer, 2019 May 30; 19(1). PMID: 31138162    Free PMC article.
Prognostic value of lymphocyte-to-monocyte ratio in ovarian cancer: a meta-analysis.
Jun Gong, Hui Jiang, +4 authors, Rong-Feng Li.
J Ovarian Res, 2019 Jun 04; 12(1). PMID: 31151469    Free PMC article.
The Immune Landscape of Thyroid Cancer in the Context of Immune Checkpoint Inhibition.
Gilda Varricchi, Stefania Loffredo, +6 authors, Maria Rosaria Galdiero.
Int J Mol Sci, 2019 Aug 16; 20(16). PMID: 31412566    Free PMC article.
Cytolytic activity correlates with the mutational burden and deregulated expression of immune checkpoints in colorectal cancer.
Apostolos Zaravinos, Constantinos Roufas, +5 authors, Georgios D Ayiomamitis.
J Exp Clin Cancer Res, 2019 Aug 21; 38(1). PMID: 31429779    Free PMC article.
B cells and tertiary lymphoid structures promote immunotherapy response.
Beth A Helmink, Sangeetha M Reddy, +57 authors, Jennifer A Wargo.
Nature, 2020 Jan 17; 577(7791). PMID: 31942075
Highly Cited.
Complement System: Promoter or Suppressor of Cancer Progression?
Margot Revel, Marie V Daugan, +2 authors, Lubka T Roumenina.
Antibodies (Basel), 2020 Oct 30; 9(4). PMID: 33113844    Free PMC article.
Peritumoral plasmacytoid dendritic cells predict a poor prognosis for intrahepatic cholangiocarcinoma after curative resection.
Zhi-Qiang Hu, Zheng-Jun Zhou, +4 authors, Shao-Lai Zhou.
Cancer Cell Int, 2020 Dec 10; 20(1). PMID: 33292317    Free PMC article.
Nanomedicines modulating tumor immunosuppressive cells to enhance cancer immunotherapy.
Yuefei Zhu, Xiangrong Yu, +2 authors, Zhiqing Pang.
Acta Pharm Sin B, 2020 Dec 12; 10(11). PMID: 33304779    Free PMC article.
Why we do what we do. A brief analysis of cancer therapies.
Carlos M Galmarini.
EXCLI J, 2020 Dec 15; 19. PMID: 33312104    Free PMC article.
TGFβ biology in cancer progression and immunotherapy.
Rik Derynck, Shannon J Turley, Rosemary J Akhurst.
Nat Rev Clin Oncol, 2020 Jul 28; 18(1). PMID: 32710082
Combining inhibition of galectin-3 with and before a therapeutic vaccination is critical for the prostate-tumor-free outcome.
Carolina Tiraboschi, Lucas Gentilini, +7 authors, Daniel Compagno.
J Immunother Cancer, 2020 Dec 10; 8(2). PMID: 33293356    Free PMC article.
Applications of Single-Cell Omics to Dissect Tumor Microenvironment.
Tingting Guo, Weimin Li, Xuyu Cai.
Front Genet, 2020 Dec 18; 11. PMID: 33329692    Free PMC article.
T Cell Dysfunction in Cancer.
Daniela S Thommen, Ton N Schumacher.
Cancer Cell, 2018 Apr 11; 33(4). PMID: 29634943    Free PMC article.
Highly Cited. Review.
Immune Cell Infiltrate and Prognosis in Gastric Cancer.
Niko Kemi, Niko Hiltunen, +9 authors, Joonas H Kauppila.
Cancers (Basel), 2020 Dec 06; 12(12). PMID: 33276550    Free PMC article.
Phagocytic function of tumor-associated macrophages as a key determinant of tumor progression control: a review.
Marc Lecoultre, Valérie Dutoit, Paul R Walker.
J Immunother Cancer, 2020 Dec 19; 8(2). PMID: 33335026    Free PMC article.
Antagonistic Inflammatory Phenotypes Dictate Tumor Fate and Response to Immune Checkpoint Blockade.
Eduardo Bonavita, Christian P Bromley, +17 authors, Santiago Zelenay.
Immunity, 2020 Nov 22; 53(6). PMID: 33220234    Free PMC article.
Co-delivery of Peptide Neoantigens and Stimulator of Interferon Genes Agonists Enhances Response to Cancer Vaccines.
Daniel Shae, Jessalyn J Baljon, +9 authors, John T Wilson.
ACS Nano, 2020 Jul 24; 14(8). PMID: 32701257    Free PMC article.
Calreticulin and cancer.
Jitka Fucikova, Radek Spisek, Guido Kroemer, Lorenzo Galluzzi.
Cell Res, 2020 Aug 01; 31(1). PMID: 32733014    Free PMC article.
Immunobiology and immunotherapy of HCC: spotlight on innate and innate-like immune cells.
Benjamin Ruf, Bernd Heinrich, Tim F Greten.
Cell Mol Immunol, 2020 Nov 26; 18(1). PMID: 33235387    Free PMC article.
Identification of tumor-associated macrophage subsets that are associated with breast cancer prognosis.
Elisabeth Strack, P Alexander Rolfe, +9 authors, Andreas Weigert.
Clin Transl Med, 2020 Dec 31; 10(8). PMID: 33377644    Free PMC article.
Immunostimulation with chemotherapy in the era of immune checkpoint inhibitors.
Lorenzo Galluzzi, Juliette Humeau, +2 authors, Guido Kroemer.
Nat Rev Clin Oncol, 2020 Aug 08; 17(12). PMID: 32760014
CD73 expression defines immune, molecular, and clinicopathological subgroups of lung adenocarcinoma.
Pedro Rocha, Ruth Salazar, +25 authors, Luisa Maren Solis.
Cancer Immunol Immunother, 2021 Jan 09; 70(7). PMID: 33416944
Nondestructive, multiplex three-dimensional mapping of immune infiltrates in core needle biopsy.
Steve Seung-Young Lee, Vytautas P Bindokas, Mark W Lingen, Stephen J Kron.
Lab Invest, 2018 Nov 08; 99(9). PMID: 30401959    Free PMC article.
Host tissue determinants of tumour immunity.
Hélène Salmon, Romain Remark, Sacha Gnjatic, Miriam Merad.
Nat Rev Cancer, 2019 Mar 15; 19(4). PMID: 30867580    Free PMC article.
Highly Cited. Review.
The application of nanoparticles in cancer immunotherapy: Targeting tumor microenvironment.
Muyue Yang, Jipeng Li, Ping Gu, Xianqun Fan.
Bioact Mater, 2021 Jan 12; 6(7). PMID: 33426371    Free PMC article.
Baseline immunity and impact of chemotherapy on immune microenvironment in cervical cancer.
Yi Zhang, Minhua Yu, +14 authors, Wen Di.
Br J Cancer, 2020 Oct 23; 124(2). PMID: 33087896    Free PMC article.
Beyond conventional immune-checkpoint inhibition - novel immunotherapies for renal cell carcinoma.
David A Braun, Ziad Bakouny, +4 authors, Toni K Choueiri.
Nat Rev Clin Oncol, 2021 Jan 14; 18(4). PMID: 33437048
Anti-NKG2D single domain-based antibodies for the modulation of anti-tumor immune response.
Adeline Raynaud, Klervi Desrumeaux, +5 authors, Brigitte Kerfelec.
Oncoimmunology, 2021 Jan 19; 10(1). PMID: 33457075    Free PMC article.
Identification and validation of poor prognosis immunoevasive subtype of muscle-invasive bladder cancer with tumor-infiltrating podoplanin+ cell abundance.
Quan Zhou, Zewei Wang, +14 authors, Jiejie Xu.
Oncoimmunology, 2021 Jan 19; 9(1). PMID: 33457092    Free PMC article.
Antitumour immunity regulated by aberrant ERBB family signalling.
Shogo Kumagai, Shohei Koyama, Hiroyoshi Nishikawa.
Nat Rev Cancer, 2021 Jan 20; 21(3). PMID: 33462501
Targeting cancer-promoting inflammation - have anti-inflammatory therapies come of age?
Jiajie Hou, Michael Karin, Beicheng Sun.
Nat Rev Clin Oncol, 2021 Jan 21; 18(5). PMID: 33469195
Tumor Microenvironment Features as Predictive Biomarkers of Response to Immune Checkpoint Inhibitors (ICI) in Metastatic Clear Cell Renal Cell Carcinoma (mccRCC).
Audrey Simonaggio, Nicolas Epaillard, +3 authors, Yann-Alexandre Vano.
Cancers (Basel), 2021 Jan 14; 13(2). PMID: 33435262    Free PMC article.
Unlocking the Power of Exosomes for Crossing Biological Barriers in Drug Delivery.
Rebekah Omarkhail Elliott, Mei He.
Pharmaceutics, 2021 Jan 23; 13(1). PMID: 33477972    Free PMC article.
m6A regulator-based methylation modification patterns characterized by distinct tumor microenvironment immune profiles in colon cancer.
Wei Chong, Liang Shang, +10 authors, Hao Chen.
Theranostics, 2021 Jan 28; 11(5). PMID: 33500720    Free PMC article.
Antibody-Based Targeting of Interferon-Beta-1a Mutein in HER2-Positive Cancer Enhances Antitumor Effects Through Immune Responses and Direct Cell Killing.
Chan Gyu Lee, TaeEun Kim, +11 authors, Young Kee Shin.
Front Pharmacol, 2021 Jan 29; 11. PMID: 33505314    Free PMC article.
Identification of a Five-Autophagy-Related-lncRNA Signature as a Novel Prognostic Biomarker for Hepatocellular Carcinoma.
Xiaoyu Deng, Qinghua Bi, +7 authors, Yao Yang.
Front Mol Biosci, 2021 Jan 29; 7. PMID: 33505990    Free PMC article.
Tumor Microenvironment Immune Response in Pancreatic Ductal Adenocarcinoma Patients Treated With Neoadjuvant Therapy.
Theodoros Michelakos, Lei Cai, +20 authors, Cristina R Ferrone.
J Natl Cancer Inst, 2020 Jun 05; 113(2). PMID: 32497200    Free PMC article.
A three-gene signature based on tumour microenvironment predicts overall survival of osteosarcoma in adolescents and young adults.
Chunkai Wen, Hongxue Wang, +8 authors, Weimin Xie.
Aging (Albany NY), 2020 Dec 08; 13(1). PMID: 33281116    Free PMC article.
Mesenchymal traits at the convergence of tumor-intrinsic and -extrinsic mechanisms of resistance to immune checkpoint blockers.
Paola Trono, Antonella Sistigu, +2 authors, Paola Nisticò.
Emerg Top Life Sci, 2017 Dec 12; 1(5). PMID: 33525801    Free PMC article.
Highly Multiplexed Digital Spatial Profiling of the Tumor Microenvironment of Head and Neck Squamous Cell Carcinoma Patients.
Arutha Kulasinghe, Touraj Taheri, +3 authors, Chamindie Punyadeera.
Front Oncol, 2021 Feb 06; 10. PMID: 33542903    Free PMC article.
Mutational Signatures Driven by Epigenetic Determinants Enable the Stratification of Patients with Gastric Cancer for Therapeutic Intervention.
Jaqueline Ramalho Buttura, Monize Nakamoto Provisor Santos, +14 authors, Israel Tojal da Silva.
Cancers (Basel), 2021 Jan 31; 13(3). PMID: 33513945    Free PMC article.
The Interplay of Exosomes and NK Cells in Cancer Biology.
Inês A Batista, Sofia T Quintas, Sónia A Melo.
Cancers (Basel), 2021 Feb 04; 13(3). PMID: 33530529    Free PMC article.
Tumor Microenvironment Status Predicts the Efficacy of Postoperative Chemotherapy or Radiochemotherapy in Resected Gastric Cancer.
Ran Duan, Xiaoqin Li, +6 authors, Deqiang Wang.
Front Immunol, 2021 Feb 12; 11. PMID: 33569057    Free PMC article.
Metabolism of immune cells in cancer.
Robert D Leone, Jonathan D Powell.
Nat Rev Cancer, 2020 Jul 08; 20(9). PMID: 32632251    Free PMC article.
Neutrophil diversity and plasticity in tumour progression and therapy.
Sebastien Jaillon, Andrea Ponzetta, +3 authors, Alberto Mantovani.
Nat Rev Cancer, 2020 Jul 23; 20(9). PMID: 32694624
The immune contexture and Immunoscore in cancer prognosis and therapeutic efficacy.
Daniela Bruni, Helen K Angell, Jérôme Galon.
Nat Rev Cancer, 2020 Aug 06; 20(11). PMID: 32753728
Inflammation-Driven Breast Tumor Cell Plasticity: Stemness/EMT, Therapy Resistance and Dormancy.
Tamir Baram, Linor Rubinstein-Achiasaf, Hagar Ben-Yaakov, Adit Ben-Baruch.
Front Oncol, 2021 Feb 16; 10. PMID: 33585241    Free PMC article.
Pro-tumorigenic functions of macrophages at the primary, invasive and metastatic tumor site.
Elaheh Nasrollahzadeh, Sepideh Razi, +2 authors, Nima Rezaei.
Cancer Immunol Immunother, 2020 Jun 06; 69(9). PMID: 32500231
Oncolytic virus promotes tumor-reactive infiltrating lymphocytes for adoptive cell therapy.
Mathilde Feist, Zhi Zhu, +11 authors, David L Bartlett.
Cancer Gene Ther, 2020 Jul 08; 28(1-2). PMID: 32632271
Anti-PD-1 antibody increases NK cell cytotoxicity towards nasopharyngeal carcinoma cells in the context of chemotherapy-induced upregulation of PD-1 and PD-L1.
Anna Makowska, Selina Meier, +3 authors, Udo Kontny.
Cancer Immunol Immunother, 2020 Aug 02; 70(2). PMID: 32737537    Free PMC article.
Immune cell infiltrates as prognostic biomarkers in pancreatic ductal adenocarcinoma: a systematic review and meta-analysis.
Andrew J McGuigan, Helen G Coleman, +4 authors, Richard C Turkington.
J Pathol Clin Res, 2021 Jan 23; 7(2). PMID: 33481339    Free PMC article.
Expression of Human Epidermal Growth Factor Receptor-2 Status and Programmed Cell Death Protein-1 Ligand Is Associated With Prognosis in Gastric Cancer.
Huifang Lv, Junling Zhang, +7 authors, Xiaobing Chen.
Front Oncol, 2021 Feb 19; 10. PMID: 33598422    Free PMC article.
Identification and Immunocorrelation of Prognosis-Related Genes Associated With Development of Muscle-Invasive Bladder Cancer.
Jingxian Li, Yantao Lou, +4 authors, Zhihong Zhang.
Front Mol Biosci, 2021 Feb 20; 7. PMID: 33604353    Free PMC article.
B cells and cancer: To B or not to B?
Wolf Herman Fridman, Florent Petitprez, +4 authors, Catherine Sautès-Fridman.
J Exp Med, 2021 Feb 19; 218(1). PMID: 33601413    Free PMC article.
Development of prognostic signature based on immune-related genes in muscle-invasive bladder cancer: bioinformatics analysis of TCGA database.
Kun Jin, Shi Qiu, +6 authors, Qiang Wei.
Aging (Albany NY), 2021 Jan 20; 13(2). PMID: 33465047    Free PMC article.
High level of EZH2 expression is linked to high density of CD8-positive T-lymphocytes and an aggressive phenotype in renal cell carcinoma.
Till Eichenauer, Luca Simmendinger, +14 authors, Michael Rink.
World J Urol, 2020 Apr 19; 39(2). PMID: 32303902    Free PMC article.
CMTM6 and PD-L1 coexpression is associated with an active immune microenvironment and a favorable prognosis in colorectal cancer.
Qi-Hua Peng, Chun-Hua Wang, +7 authors, Ran-Yi Liu.
J Immunother Cancer, 2021 Feb 14; 9(2). PMID: 33579737    Free PMC article.
Crosstalk between Macrophages, T Cells, and Iron Metabolism in Tumor Microenvironment.
Lesang Shen, Yunxiang Zhou, +6 authors, Jian Huang.
Oxid Med Cell Longev, 2021 Feb 26; 2021. PMID: 33628389    Free PMC article.
The Periphery of Salivary Gland Carcinoma Tumors Reveals a PD-L1/PD-1 Biomarker Niche for the Evaluation of Disease Severity and Tumor-Immune System Interplay.
Martin Kuchar, Zuzana Strizova, +5 authors, Jan Plzak.
Biomedicines, 2021 Jan 28; 9(2). PMID: 33498270    Free PMC article.
Tumor Microenvironment, HLA Class I and APM Expression in HPV-Negative Oral Squamous Cell Carcinoma.
Claudia Wickenhauser, Daniel Bethmann, +6 authors, Barbara Seliger.
Cancers (Basel), 2021 Feb 10; 13(4). PMID: 33557271    Free PMC article.
Antibiotic-Related Changes in Microbiome: The Hidden Villain behind Colorectal Carcinoma Immunotherapy Failure.
Tsvetelina Velikova, Boris Krastev, +4 authors, Milena Peruhova.
Int J Mol Sci, 2021 Feb 14; 22(4). PMID: 33578709    Free PMC article.
Site-specific metastasis: A cooperation between cancer cells and the metastatic microenvironment.
Sivan Izraely, Isaac P Witz.
Int J Cancer, 2020 Aug 08; 148(6). PMID: 32761606    Free PMC article.
Exploration of the immune cell infiltration-related gene signature in the prognosis of melanoma.
Yangyang Zeng, Yulan Zeng, +4 authors, Yunfeng Zhou.
Aging (Albany NY), 2021 Jan 12; 13(3). PMID: 33428606    Free PMC article.
Phosphorylation of SMAD3 in immune cells predicts survival of patients with early stage non-small cell lung cancer.
Sebastian Marwitz, Carmen Ballesteros-Merino, +6 authors, Bernard A Fox.
J Immunother Cancer, 2021 Feb 17; 9(2). PMID: 33589523    Free PMC article.
Intratumoral CXCL13+CD8+T cell infiltration determines poor clinical outcomes and immunoevasive contexture in patients with clear cell renal cell carcinoma.
Siyuan Dai, Han Zeng, +15 authors, Jiejie Xu.
J Immunother Cancer, 2021 Feb 17; 9(2). PMID: 33589528    Free PMC article.
Immunosuppression in Gliomas via PD-1/PD-L1 Axis and Adenosine Pathway.
Thamiris Becker Scheffel, Nathália Grave, +3 authors, Fernanda Bueno Morrone.
Front Oncol, 2021 Mar 05; 10. PMID: 33659213    Free PMC article.
Integrated Characterization of lncRNA-Immune Interactions in Prostate Cancer.
Wei Hu, Yanru Wang, +2 authors, Shengli Li.
Front Cell Dev Biol, 2021 Mar 06; 9. PMID: 33665192    Free PMC article.
Immune Regulation of the cGAS-STING Signaling Pathway in the Tumor Microenvironment and Its Clinical Application.
Feifei Pu, Fengxia Chen, +2 authors, Zengwu Shao.
Onco Targets Ther, 2021 Mar 11; 14. PMID: 33688199    Free PMC article.
Induction of Immune Response Against Metastatic Tumors via Vaccination of Mannan-BAM, TLR Ligands and Anti-CD40 Antibody (MBTA).
Rogelio Medina, Herui Wang, +15 authors, Zhengping Zhuang.
Adv Ther (Weinh), 2021 Mar 13; 3(9). PMID: 33709018    Free PMC article.
PD-L1+ dendritic cells in the tumor microenvironment correlate with good prognosis and CD8+ T cell infiltration in colon cancer.
Timothy J Miller, Chidozie C Anyaegbu, +3 authors, Melanie J McCoy.
Cancer Sci, 2020 Dec 22; 112(3). PMID: 33345422    Free PMC article.
Identification and validation of a prognostic signature and combination drug therapy for immunotherapy of head and neck squamous cell carcinoma.
Weijie Qiang, Yifei Dai, Xiaoyan Xing, Xiaobo Sun.
Comput Struct Biotechnol J, 2021 Mar 16; 19. PMID: 33717423    Free PMC article.
A Prognostic Signature Based on Immunogenomic Profiling Offers Guidance for Esophageal Squamous Cell Cancer Treatment.
Jianyao Gao, Ting Tang, Baohui Zhang, Guang Li.
Front Oncol, 2021 Mar 16; 11. PMID: 33718151    Free PMC article.
Macrophages and Extracellular Matrix in Breast Cancer: Partners in Crime or Protective Allies?
Claire Deligne, Kim S Midwood.
Front Oncol, 2021 Mar 16; 11. PMID: 33718177    Free PMC article.
Clinical and immunological effects of mRNA vaccines in malignant diseases.
Annkristin Heine, Stefan Juranek, Peter Brossart.
Mol Cancer, 2021 Mar 17; 20(1). PMID: 33722265    Free PMC article.
Tumor cell intrinsic RON signaling suppresses innate immune responses in breast cancer through inhibition of IRAK4 signaling.
Jennifer R Bourn, Sasha J Ruiz-Torres, +2 authors, Susan E Waltz.
Cancer Lett, 2021 Jan 29; 503. PMID: 33508385    Free PMC article.
Plinabulin, a Distinct Microtubule-Targeting Chemotherapy, Promotes M1-Like Macrophage Polarization and Anti-tumor Immunity.
Marina Natoli, Petra Herzig, +10 authors, Abhishek S Kashyap.
Front Oncol, 2021 Mar 23; 11. PMID: 33747968    Free PMC article.
An immune-related seven-lncRNA signature for head and neck squamous cell carcinoma.
Yue Chen, Tian-Qi Luo, +4 authors, Yan-Ping Mao.
Cancer Med, 2021 Mar 05; 10(7). PMID: 33660378    Free PMC article.
Biomarkers for Immunotherapy of Oral Squamous Cell Carcinoma: Current Status and Challenges.
Alhadi Almangush, Ilmo Leivo, Antti A Mäkitie.
Front Oncol, 2021 Mar 26; 11. PMID: 33763354    Free PMC article.
Tumor microenvironment-associated gene C3 can predict the prognosis of colorectal adenocarcinoma: a study based on TCGA.
Y Liu, X Wang.
Clin Transl Oncol, 2021 Mar 26;. PMID: 33765255
Microenvironment Analysis of Prognosis and Molecular Signature of Immune-Related Genes in Lung Adenocarcinoma.
Bo Ling, Zuliang Huang, +3 authors, Qianli Tang.
Oncol Res, 2020 May 31; 28(6). PMID: 32471520    Free PMC article.
Predicting the Level of Tumor-Infiltrating Lymphocytes in Patients With Breast Cancer: Usefulness of Mammographic Radiomics Features.
Hongwei Yu, Xianqi Meng, +9 authors, Guolin Ma.
Front Oncol, 2021 Mar 30; 11. PMID: 33777776    Free PMC article.
ASO Author Reflections: Optimization of Tumor Therapy for the Specific Immune Microenvironment of Gastric Cancer.
Xudong He, Yifan Cao, +13 authors, Hongyong He.
Ann Surg Oncol, 2021 Mar 31;. PMID: 33782801
Comprehensive analysis of immune-related prognostic genes in the tumour microenvironment of hepatocellular carcinoma.
Weike Gao, Luan Li, +11 authors, Guangjun Shi.
BMC Cancer, 2021 Apr 02; 21(1). PMID: 33789609    Free PMC article.
Tumor-infiltrating lymphocytes in the immunotherapy era.
Sterre T Paijens, Annegé Vledder, Marco de Bruyn, Hans W Nijman.
Cell Mol Immunol, 2020 Nov 04; 18(4). PMID: 33139907    Free PMC article.
Prognostic value of the baseline circulating T cell receptor β chain diversity in advanced lung cancer.
Jiaqi Wang, Zhixin Bie, +10 authors, Lin Feng.
Oncoimmunology, 2021 Apr 03; 10(1). PMID: 33796410    Free PMC article.
Association of TRF2 expression and myeloid-derived suppressor cells infiltration with clinical outcome of patients with cutaneous melanoma.
Marius Ilié, Elisabeth Lantéri, +12 authors, Paul Hofman.
Oncoimmunology, 2021 Apr 03; 10(1). PMID: 33796413    Free PMC article.
Histopathological and Immune Prognostic Factors in Colo-Rectal Liver Metastases.
Alessandra Rigamonti, Friedrich Feuerhake, +2 authors, Federica Marchesi.
Cancers (Basel), 2021 Apr 04; 13(5). PMID: 33802446    Free PMC article.
Emerging Trends for Radio-Immunotherapy in Rectal Cancer.
Claudia Corrò, Valérie Dutoit, Thibaud Koessler.
Cancers (Basel), 2021 Apr 04; 13(6). PMID: 33803620    Free PMC article.
Baseline Characteristics and Outcomes of Cancer Patients Infected with SARS-CoV-2 in the Lombardy Region, Italy (AIOM-L CORONA): A Multicenter, Observational, Ambispective, Cohort Study.
Serena Di Cosimo, Barbara Tagliaferri, +30 authors, Marco Danova.
Cancers (Basel), 2021 Apr 04; 13(6). PMID: 33809465    Free PMC article.
Immunotherapy for pancreatic cancer: chasing the light at the end of the tunnel.
Thomas P Brouwer, Alexander L Vahrmeijer, Noel F C C de Miranda.
Cell Oncol (Dordr), 2021 Mar 13; 44(2). PMID: 33710604    Free PMC article.
Myeloid PTEN promotes chemotherapy-induced NLRP3-inflammasome activation and antitumour immunity.
Yi Huang, Huanyu Wang, +22 authors, Rongbin Zhou.
Nat Cell Biol, 2020 May 06; 22(6). PMID: 32367047
Advances in immunotherapy for hepatocellular carcinoma.
Bruno Sangro, Pablo Sarobe, Sandra Hervás-Stubbs, Ignacio Melero.
Nat Rev Gastroenterol Hepatol, 2021 Apr 15;. PMID: 33850328    Free PMC article.
Locally advanced gastroesophageal junction cancer with pathological complete response to neoadjuvant therapy: a case report and literature review.
Xiaoying Li, Qian Huang, +4 authors, Ming Liu.
Ann Transl Med, 2021 Apr 15; 9(6). PMID: 33850910    Free PMC article.
Increased tumor-infiltrating plasmacytoid dendritic cells promote cancer cell proliferation and invasion via TNF-α/NF-κB/CXCR-4 pathway in oral squamous cell carcinoma.
Nannan Han, Xing Li, +5 authors, Chenping Zhang.
J Cancer, 2021 Apr 16; 12(10). PMID: 33854604    Free PMC article.
Tertiary lymphoid structures and B lymphocytes in cancer prognosis and response to immunotherapies.
Jacquelot N, Tellier J, Nutt Sl, Belz Gt.
Oncoimmunology, 2021 Apr 16; 10(1). PMID: 33854820    Free PMC article.
Establishment and validation of an eight-gene metabolic-related prognostic signature model for lung adenocarcinoma.
Weishuang Ma, Jiaming Liang, +2 authors, Zisheng Chen.
Aging (Albany NY), 2021 Feb 24; 13(6). PMID: 33619235    Free PMC article.
An integrated multi-omics analysis identifies prognostic molecular subtypes of non-muscle-invasive bladder cancer.
Sia Viborg Lindskrog, Frederik Prip, +44 authors, Lars Dyrskjøt.
Nat Commun, 2021 Apr 18; 12(1). PMID: 33863885    Free PMC article.
Genomic profile and immune contexture in colorectal cancer-relevance for prognosis and immunotherapy.
Sandra Meršaková, Zora Lasabová, +7 authors, Peter Mikolajčík.
Clin Exp Med, 2020 Jul 29; 21(2). PMID: 32720224
Tumor-infiltrating plasmacytoid dendritic cells are associated with survival in human colon cancer.
Maximilian Kießler, Ioana Plesca, +16 authors, Marc Schmitz.
J Immunother Cancer, 2021 Mar 26; 9(3). PMID: 33762320    Free PMC article.
Prognostic value of LRRC4C in Colon and Gastric Cancers correlates with Tumour Microenvironment Immunity.
XiaoFeng Yang, Purun Lei, +3 authors, HongBo Wei.
Int J Biol Sci, 2021 Apr 20; 17(5). PMID: 33867855    Free PMC article.
Apatinib combined with PD-L1 blockade synergistically enhances antitumor immune responses and promotes HEV formation in gastric cancer.
Yu Zhang, Fei Wang, +3 authors, Hua Huang.
J Cancer Res Clin Oncol, 2021 Apr 24;. PMID: 33891173
CD244+ polymorphonuclear myeloid‑derived suppressor cells reflect the status of peritoneal dissemination in a colon cancer mouse model.
Yutaka Sugita, Kimihiro Yamashita, +12 authors, Yoshihiro Kakeji.
Oncol Rep, 2021 Apr 29; 45(6). PMID: 33907826    Free PMC article.
Assessment of Immunological Features in Muscle-Invasive Bladder Cancer Prognosis Using Ensemble Learning.
Christos G Gavriel, Neofytos Dimitriou, +5 authors, Peter D Caie.
Cancers (Basel), 2021 May 01; 13(7). PMID: 33915698    Free PMC article.
The Future of Cancer Diagnosis, Treatment and Surveillance: A Systemic Review on Immunotherapy and Immuno-PET Radiotracers.
Virginia Liberini, Riccardo Laudicella, +5 authors, Désirée Deandreis.
Molecules, 2021 May 01; 26(8). PMID: 33920423    Free PMC article.
Systematic Review.
Natural Polysaccharides and Their Derivates: A Promising Natural Adjuvant for Tumor Immunotherapy.
Ye Li, Xiaomin Wang, +3 authors, Changgang Sun.
Front Pharmacol, 2021 May 04; 12. PMID: 33935714    Free PMC article.
Radiomic biomarkers of tumor immune biology and immunotherapy response.
Jarey H Wang, Kareem A Wahid, +3 authors, Clifton David Fuller.
Clin Transl Radiat Oncol, 2021 May 04; 28. PMID: 33937530    Free PMC article.
Stromal categorization in early oral tongue cancer.
Alhadi Almangush, Ibrahim O Bello, +8 authors, Ilmo Leivo.
Virchows Arch, 2020 Sep 22; 478(5). PMID: 32955604    Free PMC article.
An immune-related signature that to improve prognosis prediction of breast cancer.
Yi Zhang, Xuebing Di, +5 authors, Yipeng Wang.
Am J Cancer Res, 2021 May 06; 11(4). PMID: 33948357    Free PMC article.
Immune evolution from preneoplasia to invasive lung adenocarcinomas and underlying molecular features.
Hitoshi Dejima, Xin Hu, +35 authors, Jianjun Zhang.
Nat Commun, 2021 May 13; 12(1). PMID: 33976164    Free PMC article.
Beneficial autoimmunity improves cancer prognosis.
Laurence Zitvogel, Claude Perreault, Olivera J Finn, Guido Kroemer.
Nat Rev Clin Oncol, 2021 May 13;. PMID: 33976418
Tertiary lymphoid structure score: a promising approach to refine the TNM staging in resected non-small cell lung cancer.
Mehrdad Rakaee, Thomas K Kilvaer, +12 authors, Tom Donnem.
Br J Cancer, 2021 Mar 17; 124(10). PMID: 33723388    Free PMC article.
Prognostic analysis of tumor mutation burden and immune infiltration in hepatocellular carcinoma based on TCGA data.
Shaoqing Liu, Qianjie Tang, +8 authors, Xu He.
Aging (Albany NY), 2021 Apr 07; 13(8). PMID: 33820866    Free PMC article.
Biological bases of cancer immunotherapy.
Maryanne M Gonzales Carazas, Joseph A Pinto, Fanny L Casado.
Expert Rev Mol Med, 2021 Mar 26; 23. PMID: 33762030    Free PMC article.
Screening and Identification of Key Microenvironment-Related Genes in Non-functioning Pituitary Adenoma.
Jing Guo, Qiuyue Fang, +3 authors, Yazhuo Zhang.
Front Genet, 2021 May 15; 12. PMID: 33986766    Free PMC article.
Identification of Immune-Related LncRNA Pairs for Predicting Prognosis and Immunotherapeutic Response in Head and Neck Squamous Cell Carcinoma.
Xueying Wang, Kui Cao, +8 authors, Susheng Miao.
Front Immunol, 2021 May 18; 12. PMID: 33995377    Free PMC article.
Comprehensive Analysis of Myeloid Signature Genes in Head and Neck Squamous Cell Carcinoma to Predict the Prognosis and Immune Infiltration.
Zhifeng Liu, Diekuo Zhang, +8 authors, Xin Zhang.
Front Immunol, 2021 May 18; 12. PMID: 33995379    Free PMC article.
Characteristics of Infiltrating Immune Cells and a Predictive Immune Model for Cervical Cancer.
Ruanmin Zou, Ruihong Gu, +4 authors, Xueqiong Zhu.
J Cancer, 2021 May 18; 12(12). PMID: 33995627    Free PMC article.
Poor clinical outcomes and immunoevasive contexture in CXCL13+CD8+ T cells enriched gastric cancer patients.
Kaifeng Jin, Yifan Cao, +13 authors, Jiejie Xu.
Oncoimmunology, 2021 May 18; 10(1). PMID: 33996266    Free PMC article.
Review of Prognostic Expression Markers for Clear Cell Renal Cell Carcinoma.
Florent Petitprez, Mira Ayadi, +3 authors, Sylvie Job.
Front Oncol, 2021 May 18; 11. PMID: 33996558    Free PMC article.
CD74+ macrophages are associated with favorable prognosis and immune contexture in hepatocellular carcinoma.
Nan Xiao, Kangshuai Li, +4 authors, Hui-Chuan Sun.
Cancer Immunol Immunother, 2021 May 20;. PMID: 34009409
Progressive immune dysfunction with advancing disease stage in renal cell carcinoma.
David A Braun, Kelly Street, +32 authors, Catherine J Wu.
Cancer Cell, 2021 Mar 13; 39(5). PMID: 33711273    Free PMC article.
In Situ Vaccination as a Strategy to Modulate the Immune Microenvironment of Hepatocellular Carcinoma.
Isabella Lurje, Wiebke Werner, +3 authors, Linda Hammerich.
Front Immunol, 2021 May 25; 12. PMID: 34025657    Free PMC article.
Immunotherapy in prostate cancer: new horizon of hurdles and hopes.
Igor Tsaur, Maximilian P Brandt, +2 authors, Guillaume Ploussard.
World J Urol, 2020 Oct 28; 39(5). PMID: 33106940
A Cancer-Specific Qualitative Method for Estimating the Proportion of Tumor-Infiltrating Immune Cells.
Huiting Xiao, Jiashuai Zhang, +7 authors, Yang Hui.
Front Immunol, 2021 Jun 01; 12. PMID: 34054849    Free PMC article.
Tertiary Lymphoid Structures as a Predictive Biomarker of Response to Cancer Immunotherapies.
Marta Trüb, Alfred Zippelius.
Front Immunol, 2021 Jun 01; 12. PMID: 34054861    Free PMC article.
Intratumoral CXCR5+CD8+T associates with favorable clinical outcomes and immunogenic contexture in gastric cancer.
Jieti Wang, Ruochen Li, +12 authors, Hua Huang.
Nat Commun, 2021 May 27; 12(1). PMID: 34035252    Free PMC article.
Heterogeneity of Colorectal Cancer Progression: Molecular Gas and Brakes.
Federica Gaiani, Federica Marchesi, +4 authors, Luigi Laghi.
Int J Mol Sci, 2021 Jun 03; 22(10). PMID: 34063506    Free PMC article.
Impact of Immunotherapy on CD4 T Cell Phenotypes and Function in Cancer.
Margaux Saillard, Mara Cenerenti, Pedro Romero, Camilla Jandus.
Vaccines (Basel), 2021 Jun 03; 9(5). PMID: 34064410    Free PMC article.
Development of Exhaustion and Acquisition of Regulatory Function by Infiltrating CD8+CD28- T Lymphocytes Dictate Clinical Outcome in Head and Neck Cancer.
Daniela Fenoglio, Liliana Belgioia, +18 authors, Gilberto Filaci.
Cancers (Basel), 2021 Jun 03; 13(9). PMID: 34066538    Free PMC article.
Integrating Machine Learning and Tumor Immune Signature to Predict Oncologic Outcomes in Resected Biliary Tract Cancer.
Gu-Wei Ji, Ke Wang, +3 authors, Xiang-Cheng Li.
Ann Surg Oncol, 2020 Nov 25; 28(7). PMID: 33230745
Glycosylation of Siglec15 promotes immunoescape and tumor growth.
Yun-Long Wang, Ming-Biao Wei, +10 authors, Xin-Juan Fan.
Am J Cancer Res, 2021 Jun 08; 11(5). PMID: 34094685    Free PMC article.
Checkpoint inhibitor therapy for metastatic triple-negative breast cancer.
Arielle L Heeke, Antoinette R Tan.
Cancer Metastasis Rev, 2021 Jun 09;. PMID: 34101053    Free PMC article.
Nanoparticle-enabled innate immune stimulation activates endogenous tumor-infiltrating T cells with broad antigen specificities.
Qian Yin, Wong Yu, +12 authors, Mark M Davis.
Proc Natl Acad Sci U S A, 2021 May 23; 118(21). PMID: 34021082    Free PMC article.