Journal Article
. 2017 Aug; 32(2):253-267.e5.
doi: 10.1016/j.ccell.2017.07.006.

Macrophage Polarization Contributes to Glioblastoma Eradication by Combination Immunovirotherapy and Immune Checkpoint Blockade

Dipongkor Saha 1 Robert L Martuza 1 Samuel D Rabkin 2 
Affiliations
  • PMID: 28810147
  •     69 References
  •     208 citations

Abstract

Glioblastoma is an immunosuppressive, fatal brain cancer that contains glioblastoma stem-like cells (GSCs). Oncolytic herpes simplex virus (oHSV) selectively replicates in cancer cells while inducing anti-tumor immunity. oHSV G47Δ expressing murine IL-12 (G47Δ-mIL12), antibodies to immune checkpoints (CTLA-4, PD-1, PD-L1), or dual combinations modestly extended survival of a mouse glioma model. However, the triple combination of anti-CTLA-4, anti-PD-1, and G47Δ-mIL12 cured most mice in two glioma models. This treatment was associated with macrophage influx and M1-like polarization, along with increased T effector to T regulatory cell ratios. Immune cell depletion studies demonstrated that CD4+ and CD8+ T cells as well as macrophages are required for synergistic curative activity. This combination should be translatable to the clinic and other immunosuppressive cancers.

Keywords: HSV; cancer stem cells; glioma; immunotherapy; oncolytic virus.

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Onco Targets Ther, 2019 Nov 07; 12. PMID: 31695427    Free PMC article.
Review.
Targeting Macrophages: Friends or Foes in Disease?
Juan A Ardura, Gorjana Rackov, +3 authors, Maria M Escribese.
Front Pharmacol, 2019 Nov 12; 10. PMID: 31708781    Free PMC article.
Review.
A novel in situ multiplex immunofluorescence panel for the assessment of tumor immunopathology and response to virotherapy in pediatric glioblastoma reveals a role for checkpoint protein inhibition.
Joshua D Bernstock, Nunzio Vicario, +15 authors, Gregory K Friedman.
Oncoimmunology, 2019 Nov 20; 8(12). PMID: 31741780    Free PMC article.
Legumain Promotes Gastric Cancer Progression Through Tumor-associated Macrophages In vitro and In vivo.
Hongbin Wang, Binghong Chen, +2 authors, Xiaobo Li.
Int J Biol Sci, 2020 Jan 02; 16(1). PMID: 31892854    Free PMC article.
CTLA-4 correlates with immune and clinical characteristics of glioma.
Fangkun Liu, Jing Huang, +3 authors, Zhixiong Liu.
Cancer Cell Int, 2020 Jan 09; 20. PMID: 31911758    Free PMC article.
CCR2 inhibition reduces tumor myeloid cells and unmasks a checkpoint inhibitor effect to slow progression of resistant murine gliomas.
Joseph A Flores-Toro, Defang Luo, +9 authors, Jeffrey K Harrison.
Proc Natl Acad Sci U S A, 2019 Dec 28; 117(2). PMID: 31879345    Free PMC article.
Symbiotic Macrophage-Glioma Cell Interactions Reveal Synthetic Lethality in PTEN-Null Glioma.
Peiwen Chen, Di Zhao, +9 authors, Ronald A DePinho.
Cancer Cell, 2019 Jun 12; 35(6). PMID: 31185211    Free PMC article.
Highly Cited.
Autophagy in the Immunosuppressive Perivascular Microenvironment of Glioblastoma.
Maria L Molina, David García-Bernal, Salvador Martinez, Rut Valdor.
Cancers (Basel), 2020 Jan 08; 12(1). PMID: 31906065    Free PMC article.
Review.
Circadian Regulator CLOCK Recruits Immune-Suppressive Microglia into the GBM Tumor Microenvironment.
Peiwen Chen, Wen-Hao Hsu, +7 authors, Ronald A DePinho.
Cancer Discov, 2020 Jan 11; 10(3). PMID: 31919052    Free PMC article.
T lymphocyte-targeted immune checkpoint modulation in glioma.
William James Kelly, Amber Jin Giles, Mark Gilbert.
J Immunother Cancer, 2020 Feb 14; 8(1). PMID: 32051289    Free PMC article.
Review.
Multidimensional communication in the microenvirons of glioblastoma.
Marike L Broekman, Sybren L N Maas, +3 authors, Xandra O Breakefield.
Nat Rev Neurol, 2018 Jul 10; 14(8). PMID: 29985475    Free PMC article.
Highly Cited. Review.
Improving efficacy of cancer immunotherapy through targeting of macrophages.
Elisa Peranzoni, Emmanuel Donnadieu.
Hum Vaccin Immunother, 2018 Sep 08; 15(1). PMID: 30192699    Free PMC article.
Eradication of glioblastoma by immuno-virotherapy with a retargeted oncolytic HSV in a preclinical model.
Francesco Alessandrini, Laura Menotti, +5 authors, Paolo Malatesta.
Oncogene, 2019 Feb 14; 38(23). PMID: 30755732
Glioblastoma stem cells: lessons from the tumor hierarchy in a lethal cancer.
Ryan C Gimple, Shruti Bhargava, Deobrat Dixit, Jeremy N Rich.
Genes Dev, 2019 Jun 05; 33(11-12). PMID: 31160393    Free PMC article.
Highly Cited. Review.
Dual CTLA-4 and PD-L1 Blockade Inhibits Tumor Growth and Liver Metastasis in a Highly Aggressive Orthotopic Mouse Model of Colon Cancer.
E Fiegle, D Doleschel, +5 authors, W Lederle.
Neoplasia, 2019 Aug 15; 21(9). PMID: 31412307    Free PMC article.
Blood-brain barrier permeable nano immunoconjugates induce local immune responses for glioma therapy.
Anna Galstyan, Janet L Markman, +18 authors, Julia Y Ljubimova.
Nat Commun, 2019 Aug 30; 10(1). PMID: 31462642    Free PMC article.
Highly Cited.
Revealing and Harnessing Tumour-Associated Microglia/Macrophage Heterogeneity in Glioblastoma.
Yolanda Pires-Afonso, Simone P Niclou, Alessandro Michelucci.
Int J Mol Sci, 2020 Jan 25; 21(3). PMID: 31973030    Free PMC article.
Review.
Demeclocycline Reduces the Growth of Human Brain Tumor-Initiating Cells: Direct Activity and Through Monocytes.
Susobhan Sarkar, Yibo Li, +6 authors, V Wee Yong.
Front Immunol, 2020 Mar 11; 11. PMID: 32153581    Free PMC article.
Extracellular vesicles in urologic malignancies-Implementations for future cancer care.
Zhangsong Wu, Zhiqiang Zhang, +3 authors, Song Wu.
Cell Prolif, 2019 Aug 31; 52(6). PMID: 31469460    Free PMC article.
Review.
Expression profiling of single cells and patient cohorts identifies multiple immunosuppressive pathways and an altered NK cell phenotype in glioblastoma.
H J Close, L F Stead, +10 authors, E B Wilson.
Clin Exp Immunol, 2019 Dec 01; 200(1). PMID: 31784984    Free PMC article.
Oncolytic Virus Encoding a Master Pro-Inflammatory Cytokine Interleukin 12 in Cancer Immunotherapy.
Hong-My Nguyen, Kirsten Guz-Montgomery, Dipongkor Saha.
Cells, 2020 Feb 14; 9(2). PMID: 32050597    Free PMC article.
Review.
Emerging trends in immunotherapy for pediatric sarcomas.
Kyle A Dyson, Brian D Stover, +4 authors, Elias J Sayour.
J Hematol Oncol, 2019 Jul 18; 12(1). PMID: 31311607    Free PMC article.
Review.
Glioblastoma infiltration of both tumor- and virus-antigen specific cytotoxic T cells correlates with experimental virotherapy responses.
Quazim A Alayo, Hirotaka Ito, +10 authors, Hiroshi Nakashima.
Sci Rep, 2020 Mar 22; 10(1). PMID: 32198420    Free PMC article.
Oncolytic viruses: overcoming translational challenges.
Jordi Martinez-Quintanilla, Ivan Seah, Melissa Chua, Khalid Shah.
J Clin Invest, 2019 Mar 05; 129(4). PMID: 30829653    Free PMC article.
Review.
Oncolytic Herpes Simplex Virus Encoding IL12 Controls Triple-Negative Breast Cancer Growth and Metastasis.
Shanawaz M Ghouse, Hong-My Nguyen, +2 authors, Dipongkor Saha.
Front Oncol, 2020 Apr 09; 10. PMID: 32266155    Free PMC article.
Targeting Myeloid Cells in Combination Treatments for Glioma and Other Tumors.
Andy S Ding, Denis Routkevitch, Christina Jackson, Michael Lim.
Front Immunol, 2019 Aug 10; 10. PMID: 31396227    Free PMC article.
Review.
Diverse immunotherapies can effectively treat syngeneic brainstem tumors in the absence of overt toxicity.
Matthew R Schuelke, Phonphimon Wongthida, +8 authors, Richard G Vile.
J Immunother Cancer, 2019 Jul 19; 7(1). PMID: 31315671    Free PMC article.
Targeting Tumor Associated Macrophages to Overcome Conventional Treatment Resistance in Glioblastoma.
Hélène Grégoire, Loris Roncali, +5 authors, Emmanuel Garcion.
Front Pharmacol, 2020 Apr 24; 11. PMID: 32322199    Free PMC article.
Review.
Development of oncolytic virotherapy: from genetic modification to combination therapy.
Qiaoshuai Lan, Shuai Xia, +4 authors, Lu Lu.
Front Med, 2020 Mar 09; 14(2). PMID: 32146606    Free PMC article.
Review.
Efficacy of a Third-Generation Oncolytic Herpes Virus G47Δ in Advanced Stage Models of Human Gastric Cancer.
Kotaro Sugawara, Miwako Iwai, +4 authors, Tomoki Todo.
Mol Ther Oncolytics, 2020 Apr 30; 17. PMID: 32346610    Free PMC article.
Current and Future Imaging Methods for Evaluating Response to Immunotherapy in Neuro-Oncology.
Benjamin B Kasten, Neha Udayakumar, +7 authors, Jason M Warram.
Theranostics, 2019 Aug 15; 9(17). PMID: 31410203    Free PMC article.
Review.
Immunotherapy for Medulloblastoma: Current Perspectives.
Tanvir F Kabir, Charles A Kunos, John L Villano, Aman Chauhan.
Immunotargets Ther, 2020 May 06; 9. PMID: 32368525    Free PMC article.
Review.
Identification of immunologic subtype and prognosis of GBM based on TNFSF14 and immune checkpoint gene expression profiling.
Shengrong Long, Mingdong Li, +2 authors, Guangyu Li.
Aging (Albany NY), 2020 Apr 21; 12(8). PMID: 32310827    Free PMC article.
In Situ Therapeutic Cancer Vaccination with an Oncolytic Virus Expressing Membrane-Tethered IL-2.
Weilin Liu, Enyong Dai, +3 authors, David L Bartlett.
Mol Ther Oncolytics, 2020 May 15; 17. PMID: 32405533    Free PMC article.
Temozolomide antagonizes oncolytic immunovirotherapy in glioblastoma.
Dipongkor Saha, Samuel D Rabkin, Robert L Martuza.
J Immunother Cancer, 2020 May 28; 8(1). PMID: 32457126    Free PMC article.
Arming oHSV with ULBP3 drives abscopal immunity in lymphocyte-depleted glioblastoma.
Hans-Georg Wirsching, Huajia Zhang, +20 authors, Eric C Holland.
JCI Insight, 2019 Jul 12; 4(13). PMID: 31292299    Free PMC article.
Friend or Foe? Recent Strategies to Target Myeloid Cells in Cancer.
Mehdi Chaib, Subhash C Chauhan, Liza Makowski.
Front Cell Dev Biol, 2020 Jun 09; 8. PMID: 32509781    Free PMC article.
Review.
PD-L1 Inhibitor Regulates the miR-33a-5p/PTEN Signaling Pathway and Can Be Targeted to Sensitize Glioblastomas to Radiation.
Wenzheng Xia, Jin Zhu, +5 authors, Shiting Li.
Front Oncol, 2020 Jun 17; 10. PMID: 32537433    Free PMC article.
Advances and potential pitfalls of oncolytic viruses expressing immunomodulatory transgene therapy for malignant gliomas.
Qing Zhang, Fusheng Liu.
Cell Death Dis, 2020 Jun 27; 11(6). PMID: 32587256    Free PMC article.
Review.
CAR-T Cells Hit the Tumor Microenvironment: Strategies to Overcome Tumor Escape.
Alba Rodriguez-Garcia, Asis Palazon, +2 authors, Sonia Guedan.
Front Immunol, 2020 Jul 07; 11. PMID: 32625204    Free PMC article.
Review.
Low-dose oncolytic adenovirus therapy overcomes tumor-induced immune suppression and sensitizes intracranial gliomas to anti-PD-1 therapy.
Zineb Belcaid, Cor Berrevoets, +13 authors, Martine L M Lamfers.
Neurooncol Adv, 2020 Jul 10; 2(1). PMID: 32642679    Free PMC article.
Multi-Habitat Radiomics Unravels Distinct Phenotypic Subtypes of Glioblastoma with Clinical and Genomic Significance.
Seung Won Choi, Hwan-Ho Cho, +13 authors, Hyunjin Park.
Cancers (Basel), 2020 Jul 02; 12(7). PMID: 32605068    Free PMC article.
FGF2 alters macrophage polarization, tumour immunity and growth and can be targeted during radiotherapy.
Jae Hong Im, Jon N Buzzelli, +7 authors, Ruth J Muschel.
Nat Commun, 2020 Aug 15; 11(1). PMID: 32792542    Free PMC article.
Therapeutic Strategies for Overcoming Immunotherapy Resistance Mediated by Immunosuppressive Factors of the Glioblastoma Microenvironment.
Tsubasa Miyazaki, Eiichi Ishikawa, Narushi Sugii, Masahide Matsuda.
Cancers (Basel), 2020 Jul 28; 12(7). PMID: 32707672    Free PMC article.
Review.
Tumor-Associated Macrophage Status in Cancer Treatment.
Anna Maria Malfitano, Simona Pisanti, +3 authors, Giuseppe Portella.
Cancers (Basel), 2020 Jul 28; 12(7). PMID: 32708142    Free PMC article.
Review.
Neutrophil depletion enhances the therapeutic effect of PD-1 antibody on glioma.
Peng-Fei Wang, Yu-Xiang Zhang, +4 authors, Chang-Xiang Yan.
Aging (Albany NY), 2020 Aug 07; 12(15). PMID: 32756015    Free PMC article.
Contributions of immune cell populations in the maintenance, progression, and therapeutic modalities of glioma.
Michael D Caponegro, Jeremy Tetsuo Miyauchi, Stella E Tsirka.
AIMS Allergy Immunol, 2018 Jan 01; 2(1). PMID: 32914058    Free PMC article.
Recent Advances in Oncolytic Virotherapy and Immunotherapy for Glioblastoma: A Glimmer of Hope in the Search for an Effective Therapy?
Aleksei A Stepanenko, Vladimir P Chekhonin.
Cancers (Basel), 2018 Dec 20; 10(12). PMID: 30563098    Free PMC article.
Review.
Current Options and Future Directions in Immune Therapy for Glioblastoma.
John Lynes, Victoria Sanchez, +2 authors, Edjah Nduom.
Front Oncol, 2018 Dec 21; 8. PMID: 30568917    Free PMC article.
Review.
The Prognostic and Therapeutic Value of PD-L1 in Glioma.
Ruo Qiao Chen, Feng Liu, Xin Yao Qiu, Xiao Qian Chen.
Front Pharmacol, 2019 Jan 29; 9. PMID: 30687086    Free PMC article.
Highly Cited. Review.
Virus-Based Immunotherapy of Glioblastoma.
Miika Martikainen, Magnus Essand.
Cancers (Basel), 2019 Feb 16; 11(2). PMID: 30764570    Free PMC article.
Highly Cited. Review.
Recent Advances in Cancer Stem Cell-Targeted Immunotherapy.
Narayanasamy Badrinath, So Young Yoo.
Cancers (Basel), 2019 Mar 08; 11(3). PMID: 30841635    Free PMC article.
Review.
Oncolytic Viruses and Immune Checkpoint Inhibition: The Best of Both Worlds.
Venkatesh Sivanandam, Christopher J LaRocca, +2 authors, Susanne G Warner.
Mol Ther Oncolytics, 2019 May 14; 13. PMID: 31080879    Free PMC article.
Highly Cited. Review.
Multi-parametric flow cytometry staining procedure for analyzing tumor-infiltrating immune cells following oncolytic herpes simplex virus immunotherapy in intracranial glioblastoma.
Praveen K Bommareddy, Devin B Lowe, +2 authors, Dipongkor Saha.
J Biol Methods, 2019 May 28; 6(2). PMID: 31123687    Free PMC article.
CD48 is a key molecule of immunomodulation affecting prognosis in glioma.
Cunyi Zou, Chen Zhu, +9 authors, Wen Cheng.
Onco Targets Ther, 2019 Jun 20; 12. PMID: 31213836    Free PMC article.
Harnessing Microglia and Macrophages for the Treatment of Glioblastoma.
Ioanna Prionisti, Léo H Bühler, Paul R Walker, Renaud B Jolivet.
Front Pharmacol, 2019 Jun 25; 10. PMID: 31231208    Free PMC article.
Review.
Neoadjuvant Use of Oncolytic Herpes Virus G47Δ Enhances the Antitumor Efficacy of Radiofrequency Ablation.
Tomoharu Yamada, Ryosuke Tateishi, +2 authors, Tomoki Todo.
Mol Ther Oncolytics, 2020 Oct 01; 18. PMID: 32995479    Free PMC article.
Minocycline in Treating Glioblastoma Multiforme: Far beyond a Conventional Antibiotic.
Amir R Afshari, Hamid Mollazadeh, Amirhossein Sahebkar.
J Oncol, 2020 Oct 06; 2020. PMID: 33014057    Free PMC article.
Review.
Efficient Delivery and Replication of Oncolytic Virus for Successful Treatment of Head and Neck Cancer.
Masakazu Hamada, Yoshiaki Yura.
Int J Mol Sci, 2020 Oct 01; 21(19). PMID: 32992948    Free PMC article.
Review.
Oncolytic Viruses as a Platform for the Treatment of Malignant Brain Tumors.
Jana de Sostoa, Valérie Dutoit, Denis Migliorini.
Int J Mol Sci, 2020 Oct 15; 21(20). PMID: 33050329    Free PMC article.
Review.
Efficacy of a novel double-controlled oncolytic adenovirus driven by the Ki67 core promoter and armed with IL-15 against glioblastoma cells.
Qing Zhang, Junwen Zhang, +3 authors, Fusheng Liu.
Cell Biosci, 2020 Nov 03; 10. PMID: 33133514    Free PMC article.
Immune Escape in Glioblastoma Multiforme and the Adaptation of Immunotherapies for Treatment.
Joshua R D Pearson, Stefania Cuzzubbo, +5 authors, Stephanie E B McArdle.
Front Immunol, 2020 Nov 13; 11. PMID: 33178210    Free PMC article.
Review.
Herpes Simplex Virus Oncolytic Immunovirotherapy: The Blossoming Branch of Multimodal Therapy.
Laura Menotti, Elisa Avitabile.
Int J Mol Sci, 2020 Nov 11; 21(21). PMID: 33167582    Free PMC article.
Review.
Identification of Immune Cell Infiltration and Immune-Related Genes in the Tumor Microenvironment of Glioblastomas.
Sicong Huang, Zijun Song, +5 authors, Jianwei Pan.
Front Immunol, 2020 Nov 17; 11. PMID: 33193404    Free PMC article.
Local Targeting of NAD+ Salvage Pathway Alters the Immune Tumor Microenvironment and Enhances Checkpoint Immunotherapy in Glioblastoma.
Ming Li, Ameya R Kirtane, +7 authors, Hiroaki Wakimoto.
Cancer Res, 2020 Oct 02; 80(22). PMID: 32998997    Free PMC article.
Research Trends of Macrophage Polarization: A Bibliometric Analysis.
Han Gao, Feng-Yan Huang, Zhi-Ping Wang.
Chin Med J (Engl), 2018 Dec 13; 131(24). PMID: 30539910    Free PMC article.
Carbon irradiation overcomes glioma radioresistance by eradicating stem cells and forming an antiangiogenic and immunopermissive niche.
Sara Chiblak, Zili Tang, +17 authors, Amir Abdollahi.
JCI Insight, 2019 Jan 25; 4(2). PMID: 30674721    Free PMC article.
Highly Cited.
Challenges and potential of PD-1/PD-L1 checkpoint blockade immunotherapy for glioblastoma.
Xin Wang, Gaochao Guo, +3 authors, Jinming Yu.
J Exp Clin Cancer Res, 2019 Feb 20; 38(1). PMID: 30777100    Free PMC article.
Highly Cited. Review.
Glial Cell Expression of PD-L1.
Priyanka Chauhan, James R Lokensgard.
Int J Mol Sci, 2019 Apr 17; 20(7). PMID: 30987269    Free PMC article.
Review.
IFI30 expression is an independent unfavourable prognostic factor in glioma.
Xiu Liu, Chunyan Song, +3 authors, Wenbin Li.
J Cell Mol Med, 2020 Sep 25; 24(21). PMID: 32969157    Free PMC article.
Strategies to Enhance the Efficacy of T-Cell Therapy for Central Nervous System Tumors.
Deepak Upreti, David Bakhshinyan, +3 authors, Sheila K Singh.
Front Immunol, 2020 Dec 08; 11. PMID: 33281826    Free PMC article.
Review.
Characterization and oncolytic virus targeting of FAP-expressing tumor-associated pericytes in glioblastoma.
Ming Li, Guoping Li, +8 authors, Hiroaki Wakimoto.
Acta Neuropathol Commun, 2020 Dec 15; 8(1). PMID: 33308315    Free PMC article.
PD-L1-Mediated Immunosuppression in Glioblastoma Is Associated With the Infiltration and M2-Polarization of Tumor-Associated Macrophages.
Zhiyuan Zhu, Hongbo Zhang, +4 authors, Mengqi Gao.
Front Immunol, 2020 Dec 18; 11. PMID: 33329573    Free PMC article.
EZH2-Inhibited MicroRNA-454-3p Promotes M2 Macrophage Polarization in Glioma.
Bin Qi, Cheng Yang, Zhanpeng Zhu, Hao Chen.
Front Cell Dev Biol, 2020 Dec 29; 8. PMID: 33363140    Free PMC article.
Tumor-associated macrophages based signaling pathway analysis and hub genes identification in glioma.
Xiang Wang, Weihai Ning, +3 authors, Chunjiang Yu.
Medicine (Baltimore), 2020 Dec 30; 99(51). PMID: 33371165    Free PMC article.
Blocking NHE1 stimulates glioma tumor immunity by restoring OXPHOS function of myeloid cells.
Md Nabiul Hasan, Lanxin Luo, +10 authors, Dandan Sun.
Theranostics, 2021 Jan 05; 11(3). PMID: 33391535    Free PMC article.
PPP2R2B downregulation is associated with immune evasion and predicts poor clinical outcomes in triple-negative breast cancer.
Zheng Li, Yaming Li, Xiaolong Wang, Qifeng Yang.
Cancer Cell Int, 2021 Jan 08; 21(1). PMID: 33407498    Free PMC article.
Immunocompetent Mouse Models in the Search for Effective Immunotherapy in Glioblastoma.
Roxanne Wouters, Sien Bevers, +2 authors, An Coosemans.
Cancers (Basel), 2020 Dec 31; 13(1). PMID: 33374542    Free PMC article.
Review.
Immunotherapeutic strategies for sarcoma: current perspectives.
Xueyao Li, Gangyang Wang, Zhengdong Cai, Wei Sun.
Am J Transl Res, 2021 Jan 14; 12(12). PMID: 33437354    Free PMC article.
Review.
Intratumoral IL-12 delivery empowers CAR-T cell immunotherapy in a pre-clinical model of glioblastoma.
Giulia Agliardi, Anna Rita Liuzzi, +17 authors, Burkhard Becher.
Nat Commun, 2021 Jan 21; 12(1). PMID: 33469002    Free PMC article.
Immunotherapeutic Efficacy of Retargeted oHSVs Designed for Propagation in an Ad Hoc Cell Line.
Andrea Vannini, Valerio Leoni, +6 authors, Gabriella Campadelli-Fiume.
Cancers (Basel), 2021 Jan 16; 13(2). PMID: 33445744    Free PMC article.
Review.
Immune response in glioma's microenvironment.
Houminji Chen, Ming Li, +4 authors, Junjie Zou.
Innov Surg Sci, 2021 Jan 30; 5(3-4). PMID: 33511267    Free PMC article.
Review.
Modification of Extracellular Matrix Enhances Oncolytic Adenovirus Immunotherapy in Glioblastoma.
Juri Kiyokawa, Yoichiro Kawamura, +8 authors, Hiroaki Wakimoto.
Clin Cancer Res, 2020 Dec 02; 27(3). PMID: 33257429    Free PMC article.
Reshaping the Immune Microenvironment by Oncolytic Herpes Simplex Virus in Murine Pancreatic Ductal Adenocarcinoma.
Liming Zhang, Wei Wang, +9 authors, Youjia Cao.
Mol Ther, 2020 Nov 02; 29(2). PMID: 33130310    Free PMC article.
Local administration of IL-12 with an HC vector results in local and metastatic tumor control in pediatric osteosarcoma.
Marta Zalacain, María Bunuales, +10 authors, Ana Patiño-García.
Mol Ther Oncolytics, 2021 Feb 13; 20. PMID: 33575468    Free PMC article.
The Current State of Oncolytic Herpes Simplex Virus for Glioblastoma Treatment.
Hong-My Nguyen, Dipongkor Saha.
Oncolytic Virother, 2021 Mar 05; 10. PMID: 33659221    Free PMC article.
Review.
Pathogenetic Features and Current Management of Glioblastoma.
Hong-My Nguyen, Kirsten Guz-Montgomery, Devin B Lowe, Dipongkor Saha.
Cancers (Basel), 2021 Mar 07; 13(4). PMID: 33670551    Free PMC article.
Review.
Remodeling of Tumor Immune Microenvironment by Oncolytic Viruses.
Bin Zhang, Xilei Wang, Ping Cheng.
Front Oncol, 2021 Mar 09; 10. PMID: 33680911    Free PMC article.
Review.
The Association of Human Herpesviruses with Malignant Brain Tumor Pathology and Therapy: Two Sides of a Coin.
Evita Athanasiou, Antonios N Gargalionis, Fotini Boufidou, Athanassios Tsakris.
Int J Mol Sci, 2021 Mar 07; 22(5). PMID: 33668202    Free PMC article.
Review.
P4HA1 Down-Regulation Inhibits Glioma Invasiveness by Promoting M1 Microglia Polarization.
Qiyan Wang, Junwen Zhang, +4 authors, Guishan Jin.
Onco Targets Ther, 2021 Mar 18; 14. PMID: 33727827    Free PMC article.
The discovery and development of oncolytic viruses: are they the future of cancer immunotherapy?
Shunchuan Zhang, Samuel D Rabkin.
Expert Opin Drug Discov, 2020 Nov 25; 16(4). PMID: 33232188    Free PMC article.
Review.
Immunotherapy for recurrent glioblastoma: practical insights and challenging prospects.
Xin Wang, Jie Lu, Gaochao Guo, Jinming Yu.
Cell Death Dis, 2021 Mar 21; 12(4). PMID: 33741903    Free PMC article.
Review.
Perspective of mesenchymal transformation in glioblastoma.
Yona Kim, Frederick S Varn, +5 authors, Sun Ha Paek.
Acta Neuropathol Commun, 2021 Mar 26; 9(1). PMID: 33762019    Free PMC article.
Review.
Context-Dependent Glioblastoma-Macrophage/Microglia Symbiosis and Associated Mechanisms.
Wenjing Xuan, Maciej S Lesniak, +2 authors, Peiwen Chen.
Trends Immunol, 2021 Mar 06; 42(4). PMID: 33663953    Free PMC article.
Review.
Parking CAR T Cells in Tumours: Oncolytic Viruses as Valets or Vandals?
Laura Evgin, Richard G Vile.
Cancers (Basel), 2021 Apr 04; 13(5). PMID: 33807553    Free PMC article.
Review.
Antitumor effects of IL-12 and GM-CSF co-expressed in an engineered oncolytic HSV-1.
Kyoung-Ju Kim, Dahye Moon, +7 authors, Kyung-Ju Choi.
Gene Ther, 2020 Nov 06; 28(3-4). PMID: 33149278
Human Herpesvirus and the Immune Checkpoint PD-1/PD-L1 Pathway: Disorders and Strategies for Survival.
Takayuki Murata.
Microorganisms, 2021 May 01; 9(4). PMID: 33917804    Free PMC article.
Review.
Immune Checkpoints in Pediatric Solid Tumors: Targetable Pathways for Advanced Therapeutic Purposes.
Claudia Cocco, Fabio Morandi, Irma Airoldi.
Cells, 2021 May 01; 10(4). PMID: 33920505    Free PMC article.
Review.
Targeting Treg cells with GITR activation alleviates resistance to immunotherapy in murine glioblastomas.
Zohreh Amoozgar, Jonas Kloepper, +19 authors, Rakesh K Jain.
Nat Commun, 2021 May 13; 12(1). PMID: 33976133    Free PMC article.
Single-cell characterization of macrophages in glioblastoma reveals MARCO as a mesenchymal pro-tumor marker.
Andrew X Chen, Robyn D Gartrell, +11 authors, Raul Rabadan.
Genome Med, 2021 May 21; 13(1). PMID: 34011400    Free PMC article.
Mechanisms of Macrophage Plasticity in the Tumor Environment: Manipulating Activation State to Improve Outcomes.
Tiffany Davia Ricketts, Nestor Prieto-Dominguez, Pramod Sreerama Gowda, Eric Ubil.
Front Immunol, 2021 May 25; 12. PMID: 34025653    Free PMC article.
Review.
Targeted systemic dendrimer delivery of CSF-1R inhibitor to tumor-associated macrophages improves outcomes in orthotopic glioblastoma.
Kevin Liaw, Rajsekhar Reddy, +6 authors, Rangaramanujam M Kannan.
Bioeng Transl Med, 2021 May 25; 6(2). PMID: 34027092    Free PMC article.
Valproic Acid-Like Compounds Enhance and Prolong the Radiotherapy Effect on Breast Cancer by Activating and Maintaining Anti-Tumor Immune Function.
Zuchao Cai, David Lim, +9 authors, Zhihui Feng.
Front Immunol, 2021 Jun 01; 12. PMID: 34054811    Free PMC article.
Immunotherapy for Glioblastoma: Current Progress and Challenges.
Miranda W Yu, Daniela F Quail.
Front Immunol, 2021 Jun 01; 12. PMID: 34054867    Free PMC article.
Review.
Genomic stratification based on microenvironment immune types and PD-L1 for tailoring therapeutic strategies in bladder cancer.
Xintong Lyu, Ping Wang, Qiao Qiao, Yuanjun Jiang.
BMC Cancer, 2021 Jun 02; 21(1). PMID: 34059019    Free PMC article.
Combination of Mesenchymal Stem Cell-Delivered Oncolytic Virus with Prodrug Activation Increases Efficacy and Safety of Colorectal Cancer Therapy.
Chun-Te Ho, Mei-Hsuan Wu, +3 authors, Shih-Chieh Hung.
Biomedicines, 2021 Jun 03; 9(5). PMID: 34068264    Free PMC article.
Development of Immunotherapy Combination Strategies in Cancer.
Timothy A Yap, Eileen E Parkes, +3 authors, Hussein A Tawbi.
Cancer Discov, 2021 Apr 04; 11(6). PMID: 33811048    Free PMC article.
Review.
Intratumoral expression of interleukin 23 variants using oncolytic vaccinia virus elicit potent antitumor effects on multiple tumor models via tumor microenvironment modulation.
Lingjuan Chen, Hongqi Chen, +10 authors, David L Bartlett.
Theranostics, 2021 Jun 08; 11(14). PMID: 34093846    Free PMC article.
Synergistic immunotherapy of glioblastoma by dual targeting of IL-6 and CD40.
Fan Yang, Zhenqiang He, +15 authors, Yi Fan.
Nat Commun, 2021 Jun 10; 12(1). PMID: 34103524    Free PMC article.
Macrophages/Microglia in the Glioblastoma Tumor Microenvironment.
Jun Ma, Clark C Chen, Ming Li.
Int J Mol Sci, 2021 Jun 03; 22(11). PMID: 34071306    Free PMC article.
Review.
Immune System-Related Changes in Preclinical GL261 Glioblastoma under TMZ Treatment: Explaining MRSI-Based Nosological Imaging Findings with RT-PCR Analyses.
Pilar Calero-Pérez, Shuang Wu, Carles Arús, Ana Paula Candiota.
Cancers (Basel), 2021 Jun 03; 13(11). PMID: 34071393    Free PMC article.
Nanoparticle-Loaded Polarized-Macrophages for Enhanced Tumor Targeting and Cell-Chemotherapy.
Teng Hou, Tianqi Wang, +7 authors, Na Zhang.
Nanomicro Lett, 2021 Jun 18; 13(1). PMID: 34138195    Free PMC article.
Innovative and Promising Strategies to Enhance Effectiveness of Immunotherapy for CNS Tumors: Where Are We?
Concetta Quintarelli, Antonio Camera, +6 authors, Biagio De Angelis.
Front Immunol, 2021 Jun 25; 12. PMID: 34163465    Free PMC article.
Review.
Genetic Alterations in Gliomas Remodel the Tumor Immune Microenvironment and Impact Immune-Mediated Therapies.
Maria B Garcia-Fabiani, Santiago Haase, +15 authors, Maria G Castro.
Front Oncol, 2021 Jun 26; 11. PMID: 34168976    Free PMC article.
Review.
Investigation of Genetic Determinants of Glioma Immune Phenotype by Integrative Immunogenomic Scale Analysis.
Binghao Zhao, Yuekun Wang, +3 authors, Wenbin Ma.
Front Immunol, 2021 Jul 06; 12. PMID: 34220791    Free PMC article.
Combination of p38 MAPK inhibitor with PD-L1 antibody effectively prolongs survivals of temozolomide-resistant glioma-bearing mice via reduction of infiltrating glioma-associated macrophages and PD-L1 expression on resident glioma-associated microglia.
Weiqi Dang, Jingfang Xiao, +10 authors, Xiuwu Bian.
Brain Tumor Pathol, 2021 Jul 08; 38(3). PMID: 34231121
Modeling oncolytic virus dynamics in the tumor microenvironment using zebrafish.
David Mealiea, Emilie Boudreau, +4 authors, J Andrea McCart.
Cancer Gene Ther, 2020 Jul 11; 28(7-8). PMID: 32647136
Fasudil prevents liver fibrosis via activating natural killer cells and suppressing hepatic stellate cells.
Qiu-Ju Han, Yong-Liang Mu, +4 authors, Jian Zhang.
World J Gastroenterol, 2021 Jul 10; 27(24). PMID: 34239271    Free PMC article.
Targeting Tumor-Associated Antigen: A Promising CAR-T Therapeutic Strategy for Glioblastoma Treatment.
Guidong Zhu, Qing Zhang, Junwen Zhang, Fusheng Liu.
Front Pharmacol, 2021 Jul 13; 12. PMID: 34248623    Free PMC article.
Review.
Radiation in Combination With Targeted Agents and Immunotherapies for Pediatric Central Nervous System Tumors - Progress, Opportunities, and Challenges.
Bo Qiu, Cassie Kline, Sabine Mueller.
Front Oncol, 2021 Jul 20; 11. PMID: 34277419    Free PMC article.
Review.
The Effect of Herpes Simplex Virus-Type-1 (HSV-1) Oncolytic Immunotherapy on the Tumor Microenvironment.
Ifeanyi Kingsley Uche, Konstantin G Kousoulas, Paul J F Rider.
Viruses, 2021 Jul 03; 13(7). PMID: 34206677    Free PMC article.
Review.
Positron emission tomography imaging with 89Zr-labeled anti-CD8 cys-diabody reveals CD8+ cell infiltration during oncolytic virus therapy in a glioma murine model.
Benjamin B Kasten, Hailey A Houson, +10 authors, Anna G Sorace.
Sci Rep, 2021 Jul 30; 11(1). PMID: 34321569    Free PMC article.
The Heterogeneity of Infiltrating Macrophages in Metastatic Osteosarcoma and Its Correlation with Immunotherapy.
Zhanchao Wang, Huiqiao Wu, +3 authors, Xinwei Wang.
J Oncol, 2021 Aug 03; 2021. PMID: 34335756    Free PMC article.
Tumor Associated Macrophages, as the Dominant Immune Cells, Are an Indispensable Target for Immunologically Cold Tumor-Glioma Therapy?
Ni Tong, Zhenqiang He, +9 authors, Qirui Wang.
Front Cell Dev Biol, 2021 Aug 10; 9. PMID: 34368156    Free PMC article.
Review.
Oncolytic Viruses for Malignant Glioma: On the Verge of Success?
Yogesh R Suryawanshi, Autumn J Schulze.
Viruses, 2021 Aug 11; 13(7). PMID: 34372501    Free PMC article.
Review.
Interactions between cancer cells and immune cells drive transitions to mesenchymal-like states in glioblastoma.
Toshiro Hara, Rony Chanoch-Myers, +18 authors, Itay Tirosh.
Cancer Cell, 2021 Jun 05; 39(6). PMID: 34087162    Free PMC article.
Crosstalk Between Tumor-Associated Microglia/Macrophages and CD8-Positive T Cells Plays a Key Role in Glioblastoma.
Sheng Tu, Xu Lin, +8 authors, Anwen Shao.
Front Immunol, 2021 Aug 17; 12. PMID: 34394072    Free PMC article.
Review.
PI3Kα inhibitor CYH33 triggers antitumor immunity in murine breast cancer by activating CD8+T cells and promoting fatty acid metabolism.
Pu Sun, Xi Zhang, +9 authors, Ling-Hua Meng.
J Immunother Cancer, 2021 Aug 11; 9(8). PMID: 34373258    Free PMC article.
Cutting both ways: the innate immune response to oncolytic virotherapy.
David Mealiea, J Andrea McCart.
Cancer Gene Ther, 2021 Aug 29;. PMID: 34453122
Review.
The Multifaceted Role of Macrophages in Oncolytic Virotherapy.
Laura Hofman, Sean E Lawler, Martine L M Lamfers.
Viruses, 2021 Aug 29; 13(8). PMID: 34452439    Free PMC article.
Review.
Mouse models of glioblastoma for the evaluation of novel therapeutic strategies.
Alexander F Haddad, Jacob S Young, +4 authors, Nicholas A Butowski.
Neurooncol Adv, 2021 Sep 02; 3(1). PMID: 34466804    Free PMC article.
Review.
Oncolytic herpes virus G47Δ works synergistically with CTLA-4 inhibition via dynamic intratumoral immune modulation.
Kotaro Sugawara, Miwako Iwai, +3 authors, Tomoki Todo.
Mol Ther Oncolytics, 2021 Sep 14; 22. PMID: 34514094    Free PMC article.
Phenotypic plasticity of myeloid cells in glioblastoma development, progression, and therapeutics.
Zengpanpan Ye, Xiaolin Ai, +3 authors, Shengtao Zhou.
Oncogene, 2021 Sep 25; 40(42). PMID: 34556813
Review.
Oncolytic herpes virus G47Δ injected into tongue cancer swiftly traffics in lymphatics and suppresses metastasis.
Toshihiro Uchihashi, Hirokazu Nakahara, +6 authors, Tomoki Todo.
Mol Ther Oncolytics, 2021 Sep 24; 22. PMID: 34553027    Free PMC article.
Treatment of glioblastoma with current oHSV variants reveals differences in efficacy and immune cell recruitment.
Joseph W Jackson, Bonnie L Hall, +7 authors, Joseph C Glorioso.
Mol Ther Oncolytics, 2021 Sep 24; 22. PMID: 34553031    Free PMC article.
The Immune Privilege of Cancer Stem Cells: A Key to Understanding Tumor Immune Escape and Therapy Failure.
Claudia Galassi, Martina Musella, +2 authors, Antonella Sistigu.
Cells, 2021 Sep 29; 10(9). PMID: 34572009    Free PMC article.
Review.
In Situ Cancer Vaccination and Immunovirotherapy Using Oncolytic HSV.
Nusrat Jahan, Shanawaz M Ghouse, Robert L Martuza, Samuel D Rabkin.
Viruses, 2021 Sep 29; 13(9). PMID: 34578321    Free PMC article.
Review.
An oncolytic virus expressing a full-length antibody enhances antitumor innate immune response to glioblastoma.
Bo Xu, Lei Tian, +10 authors, Jianhua Yu.
Nat Commun, 2021 Oct 10; 12(1). PMID: 34625564    Free PMC article.
Clinical Value of TXNDC12 Combined With IDH and 1p19q as Biomarkers for Prognosis of Glioma.
Xinzhuang Wang, Quan Yang, +3 authors, Xu Hou.
Pathol Oncol Res, 2021 Oct 12; 27. PMID: 34629960    Free PMC article.
Immunovirotherapy for the Treatment of Glioblastoma and Other Malignant Gliomas.
Dagoberto Estevez-Ordonez, Gustavo Chagoya, +8 authors, James M Markert.
Neurosurg Clin N Am, 2021 Mar 31; 32(2). PMID: 33781507    Free PMC article.
Review.
Oncolytic Viro-Immunotherapy: An Emerging Option in the Treatment of Gliomas.
Jiayi Zeng, Xiangxue Li, +3 authors, Yuan Lin.
Front Immunol, 2021 Oct 23; 12. PMID: 34675919    Free PMC article.
Review.
Phosphor-IWS1-dependent U2AF2 splicing regulates trafficking of CAR-E-positive intronless gene mRNAs and sensitivity to viral infection.
Georgios I Laliotis, Adam D Kenney, +10 authors, Philip N Tsichlis.
Commun Biol, 2021 Oct 13; 4(1). PMID: 34635782    Free PMC article.
Harnessing nanomedicine for enhanced immunotherapy for breast cancer brain metastases.
Christine P Carney, Nikhil Pandey, +3 authors, Anthony J Kim.
Drug Deliv Transl Res, 2021 Oct 31; 11(6). PMID: 34716900    Free PMC article.
Review.
Synergy between Toxoplasma gondii type I ΔGRA17 immunotherapy and PD-L1 checkpoint inhibition triggers the regression of targeted and distal tumors.
Yu-Chao Zhu, Hany M Elsheikha, +4 authors, Jia Chen.
J Immunother Cancer, 2021 Nov 03; 9(11). PMID: 34725213    Free PMC article.
Dendritic Cell Vaccination of Glioblastoma: Road to Success or Dead End.
Angeliki Datsi, Rüdiger V Sorg.
Front Immunol, 2021 Nov 20; 12. PMID: 34795675    Free PMC article.
Review.
Neurosurgery at the crossroads of immunology and nanotechnology. New reality in the COVID-19 pandemic.
Vladimir A Ljubimov, Arshia Ramesh, +3 authors, Keith L Black.
Adv Drug Deliv Rev, 2021 Nov 23; 181. PMID: 34808227    Free PMC article.
Review.
Efficacy and safety of a third-generation oncolytic herpes virus G47Δ in models of human esophageal carcinoma.
Shoh Yajima, Kotaro Sugawara, +3 authors, Tomoki Todo.
Mol Ther Oncolytics, 2021 Dec 03; 23. PMID: 34853811    Free PMC article.
Oncolytic Virotherapy: From Bench to Bedside.
Ludi Yang, Xiang Gu, +2 authors, Xianqun Fan.
Front Cell Dev Biol, 2021 Dec 14; 9. PMID: 34901031    Free PMC article.
Review.
Oncolytic measles vaccines encoding PD-1 and PD-L1 checkpoint blocking antibodies to increase tumor-specific T cell memory.
Rūta Veinalde, Gemma Pidelaserra-Martí, +6 authors, Christine E Engeland.
Mol Ther Oncolytics, 2022 Jan 04; 24. PMID: 34977341    Free PMC article.
Combination therapy with immune checkpoint inhibitors (ICIs); a new frontier.
Somayeh Vafaei, Angelina O Zekiy, +4 authors, Majid Zamani.
Cancer Cell Int, 2022 Jan 05; 22(1). PMID: 34980128    Free PMC article.
Review.
TMEM158 promotes the proliferation and migration of glioma cells via STAT3 signaling in glioblastomas.
Jiabo Li, Xuya Wang, +20 authors, Xuejun Yang.
Cancer Gene Ther, 2022 Jan 08;. PMID: 34992215
Cancer stem cells: a major culprit of intra-tumor heterogeneity.
Faiza Naz, Mengran Shi, +2 authors, Changyuan Yu.
Am J Cancer Res, 2022 Jan 13; 11(12). PMID: 35018226    Free PMC article.
Review.
Interleukin-12 as an in situ cancer vaccine component: a review.
Emily M Cheng, Noah W Tsarovsky, Paul M Sondel, Alexander L Rakhmilevich.
Cancer Immunol Immunother, 2022 Jan 14;. PMID: 35024897
Review.
Successful treatment of a 19-year-old patient with locally advanced clear cell adenocarcinoma of the uterine cervix using recombinant human adenovirus type 5 (Oncorine) combined with chemoradiotherapy: a case report.
Jing Zhang, Zi Liu, +5 authors, Tuo-Tuo Gong.
Ann Transl Med, 2022 Jan 25; 9(23). PMID: 35071441    Free PMC article.
Immunotherapy for glioblastoma: the promise of combination strategies.
Mathilde Bausart, Véronique Préat, Alessio Malfanti.
J Exp Clin Cancer Res, 2022 Jan 27; 41(1). PMID: 35078492    Free PMC article.
Review.
Fatty Acids, CD36, Thrombospondin-1, and CD47 in Glioblastoma: Together and/or Separately?
Cristiana Tanase, Ana Maria Enciu, +7 authors, Mihail Eugen Hinescu.
Int J Mol Sci, 2022 Jan 22; 23(2). PMID: 35054787    Free PMC article.
Review.
Dual role of ARPC1B in regulating the network between tumor-associated macrophages and tumor cells in glioblastoma.
Tianqi Liu, Chen Zhu, +8 authors, Anhua Wu.
Oncoimmunology, 2022 Feb 04; 11(1). PMID: 35111386    Free PMC article.
ERK1/2 phosphorylation predicts survival following anti-PD-1 immunotherapy in recurrent glioblastoma.
Víctor A Arrieta, Andrew X Chen, +39 authors, Adam M Sonabend.
Nat Cancer, 2022 Feb 06; 2(12). PMID: 35121903    Free PMC article.
Immune Activity and Response Differences of Oncolytic Viral Therapy in Recurrent Glioblastoma: Gene Expression Analyses of a Phase IB Study.
Katherine E Miller, Kevin A Cassady, +11 authors, James M Markert.
Clin Cancer Res, 2022 Feb 03; 28(3). PMID: 35105718    Free PMC article.
Tumor-Associated Macrophages/Microglia in Glioblastoma Oncolytic Virotherapy: A Double-Edged Sword.
Sarah E Blitz, Ari D Kappel, +8 authors, Joshua D Bernstock.
Int J Mol Sci, 2022 Feb 16; 23(3). PMID: 35163730    Free PMC article.
Review.
Combining nanomedicine and immune checkpoint therapy for cancer immunotherapy.
Christine E Boone, Lu Wang, +2 authors, Nicole F Steinmetz.
Wiley Interdiscip Rev Nanomed Nanobiotechnol, 2021 Jul 24; 14(1). PMID: 34296535    Free PMC article.
Review.
Tumor-Associated Macrophages in Gliomas-Basic Insights and Treatment Opportunities.
Johannes K Andersen, Hrvoje Miletic, Jubayer A Hossain.
Cancers (Basel), 2022 Mar 11; 14(5). PMID: 35267626    Free PMC article.
Review.
Oncolytic Virotherapy in Peritoneal Metastasis Gastric Cancer: The Challenges and Achievements.
Su Shao, Xue Yang, +5 authors, Pei-Yang Hu.
Front Mol Biosci, 2022 Mar 18; 9. PMID: 35295845    Free PMC article.
Review.
NOTCH-Induced MDSC Recruitment after oHSV Virotherapy in CNS Cancer Models Modulates Antitumor Immunotherapy.
Yoshihiro Otani, Ji Young Yoo, +19 authors, Balveen Kaur.
Clin Cancer Res, 2022 Jan 14; 28(7). PMID: 35022322    Free PMC article.
Implications of immune cells in oncolytic herpes simplex virotherapy for glioma.
Yoshihiro Otani, Ji Young Yoo, +3 authors, Balveen Kaur.
Brain Tumor Pathol, 2022 Apr 07; 39(2). PMID: 35384530
Review.
Engineering strategies to enhance oncolytic viruses in cancer immunotherapy.
Yaomei Tian, Daoyuan Xie, Li Yang.
Signal Transduct Target Ther, 2022 Apr 08; 7(1). PMID: 35387984    Free PMC article.
Review.
Tumor immunotherapies by immune checkpoint inhibitors (ICIs); the pros and cons.
Adel Naimi, Rebar N Mohammed, +11 authors, Ehsan Razeghian.
Cell Commun Signal, 2022 Apr 09; 20(1). PMID: 35392976    Free PMC article.
Review.
The Role of Immune Checkpoint Molecules on Macrophages in Cancer, Infection, and Autoimmune Pathologies.
Victoria C Brom, Christof Burger, Dieter C Wirtz, Frank A Schildberg.
Front Immunol, 2022 Apr 15; 13. PMID: 35418973    Free PMC article.
Review.
Association between high immune activity and worse prognosis in uveal melanoma and low-grade glioma in TCGA transcriptomic data.
Hitoshi Matsuo, Takashi Kamatani, +2 authors, Tatsuhiko Tsunoda.
BMC Genomics, 2022 May 08; 23(1). PMID: 35525921    Free PMC article.
Characterization of the Ferroptosis-Related Genes for Prognosis and Immune Infiltration in Low-Grade Glioma.
Xiuwei Yan, Hang Ji, +11 authors, Shaoshan Hu.
Front Genet, 2022 May 14; 13. PMID: 35559020    Free PMC article.
Rat and Mouse Brain Tumor Models for Experimental Neuro-Oncology Research.
Upasana Sahu, Rolf F Barth, +2 authors, Balveen Kaur.
J Neuropathol Exp Neurol, 2022 Apr 22; 81(5). PMID: 35446393    Free PMC article.
Review.
Genome Instability-Associated Long Non-Coding RNAs Reveal Biomarkers for Glioma Immunotherapy and Prognosis.
Xinzhuang Wang, Hong Zhang, +10 authors, Dayong Han.
Front Genet, 2022 May 17; 13. PMID: 35571034    Free PMC article.
Roles for macrophage-polarizing interleukins in cancer immunity and immunotherapy.
Keywan Mortezaee, Jamal Majidpoor.
Cell Oncol (Dordr), 2022 May 20; 45(3). PMID: 35587857
Review.
Oncolytic viral vectors in the era of diversified cancer therapy: from preclinical to clinical.
Chao Tang, Lan Li, +8 authors, Liping Zhong.
Clin Transl Oncol, 2022 May 26;. PMID: 35612653
Review.
Translational landscape of glioblastoma immunotherapy for physicians: guiding clinical practice with basic scientific evidence.
Daniel Kreatsoulas, Chelsea Bolyard, +3 authors, Zihai Li.
J Hematol Oncol, 2022 Jun 12; 15(1). PMID: 35690784
Review.