Journal Article
. 2017 Aug;28(8).
doi: 10.1093/annonc/mdx308.

De-escalating and escalating treatments for early-stage breast cancer: the St. Gallen International Expert Consensus Conference on the Primary Therapy of Early Breast Cancer 2017

G Curigliano 1 H J Burstein 2 E P Winer 2 M Gnant 3 P Dubsky 3 S Loibl 4 M Colleoni 1 M M Regan 5 M Piccart-Gebhart 6 H-J Senn 7 B Thürlimann 8 St. Gallen International Expert Consensus on the Primary Therapy of Early Breast Cancer 2017  F André 9 J Baselga 10 J Bergh 11 H Bonnefoi 12 S Y Brucker 13 F Cardoso 14 L Carey 15 E Ciruelos 16 J Cuzick 17 C Denkert 18 A Di Leo 19 B Ejlertsen 20 P Francis 21 V Galimberti 1 J Garber 2 B Gulluoglu 22 P Goodwin 23 N Harbeck 24 D F Hayes 25 C-S Huang 26 J Huober 27 K Hussein 28 J Jassem 29 Z Jiang 30 P Karlsson 31 M Morrow 10 R Orecchia 1 K C Osborne 32 O Pagani 33 A H Partridge 2 K Pritchard 34 J Ro 35 E J T Rutgers 36 F Sedlmayer 37 V Semiglazov 38 Z Shao 39 I Smith 40 M Toi 41 A Tutt 42 G Viale 43 T Watanabe 44 T J Whelan 45 B Xu 46 
Affiliations
  • PMID: 28838210
  •     72 References
  •     222 citations

Abstract

The 15th St. Gallen International Breast Cancer Conference 2017 in Vienna, Austria reviewed substantial new evidence on loco-regional and systemic therapies for early breast cancer. Treatments were assessed in light of their intensity, duration and side-effects, seeking where appropriate to escalate or de-escalate therapies based on likely benefits as predicted by tumor stage and tumor biology. The Panel favored several interventions that may reduce surgical morbidity, including acceptance of 2 mm margins for DCIS, the resection of residual cancer (but not baseline extent of cancer) in women undergoing neoadjuvant therapy, acceptance of sentinel node biopsy following neoadjuvant treatment of many patients, and the preference for neoadjuvant therapy in HER2 positive and triple-negative, stage II and III breast cancer. The Panel favored escalating radiation therapy with regional nodal irradiation in high-risk patients, while encouraging omission of boost in low-risk patients. The Panel endorsed gene expression signatures that permit avoidance of chemotherapy in many patients with ER positive breast cancer. For women with higher risk tumors, the Panel escalated recommendations for adjuvant endocrine treatment to include ovarian suppression in premenopausal women, and extended therapy for postmenopausal women. However, low-risk patients can avoid these treatments. Finally, the Panel recommended bisphosphonate use in postmenopausal women to prevent breast cancer recurrence. The Panel recognized that recommendations are not intended for all patients, but rather to address the clinical needs of the majority of common presentations. Individualization of adjuvant therapy means adjusting to the tumor characteristics, patient comorbidities and preferences, and managing constraints of treatment cost and access that may affect care in both the developed and developing world.

Keywords: St Gallen Consensus; early breast cancer; radiation therapy; surgery; systemic adjuvant therapies.

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Oncotarget, 2018 Jun 02; 9(32). PMID: 29854320    Free PMC article.
Clinical practice guidelines in breast cancer.
N Kumar Tyagi, S Dhesy-Thind.
Curr Oncol, 2018 Jun 19; 25(Suppl 1). PMID: 29910658    Free PMC article.
Review.
Correction to: Biomarkers in breast cancer: A consensus statement by the Spanish Society of Medical Oncology and the Spanish Society of Pathology.
R Colomer, I Aranda-López, +7 authors, J Palacios-Calvo.
Clin Transl Oncol, 2018 Jun 20; 20(8). PMID: 29916189    Free PMC article.
Should age impact breast cancer management in young women? Fine tuning of treatment guidelines.
Matteo B Suter, Olivia Pagani.
Ther Adv Med Oncol, 2018 Jul 07; 10. PMID: 29977348    Free PMC article.
Review.
Optimal management of luminal breast cancer: how much endocrine therapy is long enough?
Elisabetta Munzone, Marco Colleoni.
Ther Adv Med Oncol, 2018 Jul 07; 10. PMID: 29977350    Free PMC article.
Review.
Neoadjuvant treatment of HER2-positive breast cancer: should therapy differ based on hormone receptor status?
Nadia Harbeck.
Ther Adv Med Oncol, 2018 Jul 24; 10. PMID: 30034548    Free PMC article.
Impact of combining the progesterone receptor and preoperative endocrine prognostic index (PEPI) as a prognostic factor after neoadjuvant endocrine therapy using aromatase inhibitors in postmenopausal ER positive and HER2 negative breast cancer.
Sasagu Kurozumi, Hiroshi Matsumoto, +7 authors, Hiroyuki Kuwano.
PLoS One, 2018 Aug 07; 13(8). PMID: 30080878    Free PMC article.
Clinical relevance of the 21-gene Recurrence Score® assay in treatment decisions for patients with node-positive breast cancer in the genomic era.
Eleftherios P Mamounas, Christy A Russell, +2 authors, Kathy S Albain.
NPJ Breast Cancer, 2018 Aug 30; 4. PMID: 30155517    Free PMC article.
Review.
Current concepts and future directions in neoadjuvant chemotherapy of breast cancer.
Rupert Bartsch, Elisabeth Bergen, Arik Galid.
Memo, 2018 Sep 18; 11(3). PMID: 30220926    Free PMC article.
Review.
An Update on Breast Cancer Multigene Prognostic Tests-Emergent Clinical Biomarkers.
André Filipe Vieira, Fernando Schmitt.
Front Med (Lausanne), 2018 Sep 21; 5. PMID: 30234119    Free PMC article.
Review.
An Italian Delphi study to evaluate consensus on adjuvant endocrine therapy in premenopausal patients with breast cancer: the ERA project.
Giacomo Pelizzari, Grazia Arpino, +8 authors, Fabio Puglisi.
BMC Cancer, 2018 Sep 29; 18(1). PMID: 30261866    Free PMC article.
Lymphovascular invasion and extranodal tumour extension are risk indicators of breast cancer related lymphoedema: an observational retrospective study with long-term follow-up.
Marco Invernizzi, Chiara Corti, +8 authors, Nicola Fusco.
BMC Cancer, 2018 Oct 01; 18(1). PMID: 30268112    Free PMC article.
[Standardized determination of tumor-infiltrating lymphocytes in breast cancer : A prognostic marker for histological diagnosis].
C Denkert, S Loibl, +2 authors, F Klauschen.
Pathologe, 2018 Oct 18; 39(6). PMID: 30327858
Review.
Sialic Acid-Binding Lectin from Bullfrog Eggs Exhibits an Anti-Tumor Effect Against Breast Cancer Cells Including Triple-Negative Phenotype Cells.
Takeo Tatsuta, Shoko Sato, +4 authors, Masahiro Hosono.
Molecules, 2018 Oct 24; 23(10). PMID: 30347895    Free PMC article.
Predicting the response to neoadjuvant therapy for early-stage breast cancer: tumor-, blood-, and imaging-related biomarkers.
Wenyong Tan, Ming Yang, +2 authors, Weixi Shen.
Cancer Manag Res, 2018 Oct 24; 10. PMID: 30349367    Free PMC article.
Review.
Clinicopathological characteristics and treatment outcomes of occult breast cancer: a SEER population-based study.
Li-Ping Ge, Xi-Yu Liu, +4 authors, Gen-Hong Di.
Cancer Manag Res, 2018 Oct 24; 10. PMID: 30349371    Free PMC article.
Prediction of pathological complete response and prognosis in patients with neoadjuvant treatment for triple-negative breast cancer.
Paul Gass, Michael P Lux, +12 authors, Marius Wunderle.
BMC Cancer, 2018 Oct 31; 18(1). PMID: 30373556    Free PMC article.
Herceptin® (trastuzumab) in HER2-positive early breast cancer: a systematic review and cumulative network meta-analysis.
Florence R Wilson, Megan E Coombes, +7 authors, Chris Cameron.
Syst Rev, 2018 Nov 16; 7(1). PMID: 30428932    Free PMC article.
Systematic Review.
Is Axillary Sentinel Lymph Node Biopsy Required in Patients Who Undergo Primary Breast Surgery?
Toralf Reimer, Jutta Engel, +3 authors, Oreste David Gentilini.
Breast Care (Basel), 2018 Dec 01; 13(5). PMID: 30498416    Free PMC article.
Review.
Current Status and Future Perspectives of Axillary Management in the Neoadjuvant Setting.
Thorsten Kühn, Jean-Marc Classe, +3 authors, Jana de Boniface.
Breast Care (Basel), 2018 Dec 01; 13(5). PMID: 30498418    Free PMC article.
What Is the Best Management of cN0pN1(sn) Breast Cancer Patients?
Jana de Boniface, Marcus Schmidt, +3 authors, Toralf Reimer.
Breast Care (Basel), 2018 Dec 01; 13(5). PMID: 30498417    Free PMC article.
Review.
Tailored axillary surgery with or without axillary lymph node dissection followed by radiotherapy in patients with clinically node-positive breast cancer (TAXIS): study protocol for a multicenter, randomized phase-III trial.
Guido Henke, Michael Knauer, +14 authors, Walter P Weber.
Trials, 2018 Dec 06; 19(1). PMID: 30514362    Free PMC article.
Moving Breast Cancer Therapy up a Notch.
Erik W J Mollen, Jonathan Ient, +4 authors, Marc A G G Vooijs.
Front Oncol, 2018 Dec 06; 8. PMID: 30515368    Free PMC article.
Review.
Non-linear transformations of age at diagnosis, tumor size, and number of positive lymph nodes in prediction of clinical outcome in breast cancer.
Carina Forsare, Martin Bak, +8 authors, Mårten Fernö.
BMC Cancer, 2018 Dec 12; 18(1). PMID: 30526533    Free PMC article.
Adjuvant Systemic Treatment of Premenopausal Women With Hormone Receptor-Positive Early Breast Cancer: Lights and Shadows.
Meredith M Regan, Gini F Fleming, +2 authors, Olivia Pagani.
J Clin Oncol, 2019 Feb 28; 37(11). PMID: 30811287    Free PMC article.
Evaluation of the Incorporation of Recurrence Score into the American Joint Committee on Cancer Eighth Edition Staging System in Patients with T1-2N0M0, Estrogen Receptor-Positive, Human Epidermal Growth Receptor 2-Negative Invasive Breast Cancer: A Population-Based Analysis.
Shuning Ding, Jiayi Wu, +6 authors, Li Zhu.
Oncologist, 2019 Apr 26; 24(11). PMID: 31019021    Free PMC article.
Impact of 21-Gene Breast Cancer Assay on Treatment Decision for Patients with T1-T3, N0-N1, Estrogen Receptor-Positive/Human Epidermal Growth Receptor 2-Negative Breast Cancer: Final Results of the Prospective Multicenter ROXANE Study.
Maria Vittoria Dieci, Valentina Guarneri, +16 authors, Veneto Oncology Network.
Oncologist, 2019 Jun 04; 24(11). PMID: 31152079    Free PMC article.
The role of Ki-67 in Asian triple negative breast cancers: a novel combinatory panel approach.
An Sen Tan, Joe Poe Sheng Yeong, +8 authors, Puay Hoon Tan.
Virchows Arch, 2019 Aug 14; 475(6). PMID: 31407032
Expression of LXR‑β, ABCA1 and ABCG1 in human triple‑negative breast cancer tissues.
Hailing Pan, Yue Zheng, +4 authors, Dingxin Di.
Oncol Rep, 2019 Aug 23; 42(5). PMID: 31432185    Free PMC article.
Agreement between molecular subtyping and surrogate subtype classification: a contemporary population-based study of ER-positive/HER2-negative primary breast cancer.
Christine Lundgren, Pär-Ola Bendahl, +15 authors, Maria Ekholm.
Breast Cancer Res Treat, 2019 Aug 23; 178(2). PMID: 31432367    Free PMC article.
Multigene expression signatures in early hormone receptor positive HER 2 negative breast cancer.
Tanja Ovcaricek, Iztok Takac, Erika Matos.
Radiol Oncol, 2019 Sep 26; 53(3). PMID: 31553709    Free PMC article.
Review.
Association of Fat Body Mass With Vertebral Fractures in Postmenopausal Women With Early Breast Cancer Undergoing Adjuvant Aromatase Inhibitor Therapy.
Rebecca Pedersini, Vito Amoroso, +13 authors, Alfredo Berruti.
JAMA Netw Open, 2019 Sep 29; 2(9). PMID: 31560383    Free PMC article.
Impact of estrogen receptor α on the tamoxifen response and prognosis in luminal-A-like and luminal-B-like breast cancer.
Nataliya Babyshkina, Sergey Vtorushin, +5 authors, Evgeny Choynzonov.
Clin Exp Med, 2019 Sep 29; 19(4). PMID: 31562548
Predictive and Prognostic Value of Selected MicroRNAs in Luminal Breast Cancer.
Maria Amorim, João Lobo, +8 authors, Carmen Jerónimo.
Front Genet, 2019 Oct 02; 10. PMID: 31572437    Free PMC article.
Excision of both pretreatment marked positive nodes and sentinel nodes improves axillary staging after neoadjuvant systemic therapy in breast cancer.
J M Simons, M L M A van Pelt, +9 authors, C C van der Pol.
Br J Surg, 2019 Oct 09; 106(12). PMID: 31593294    Free PMC article.
In Vitro and In Vivo Study on the Effect of Lysosome-associated Protein Transmembrane 4 Beta on the Progression of Breast Cancer.
Deyou Tao, Junqing Liang, +13 authors, Xia Wu.
J Breast Cancer, 2019 Oct 11; 22(3). PMID: 31598338    Free PMC article.
Adjuvant chemotherapy and survival among patients 70 years of age and younger with node-negative breast cancer and the 21-gene recurrence score of 26-30.
Seho Park, Yunan Han, +7 authors, Yikyung Park.
Breast Cancer Res, 2019 Oct 18; 21(1). PMID: 31619259    Free PMC article.
Variability of predictive markers (hormone receptors, Her2, Ki67) and intrinsic subtypes of breast cancer in four consecutive years 2015-2018.
Lidija Stevanovic, Matthias Choschzick, Linda Moskovszky, Zsuzsanna Varga.
J Cancer Res Clin Oncol, 2019 Oct 20; 145(12). PMID: 31628534    Free PMC article.
Expression of MHC class I, HLA-A and HLA-B identifies immune-activated breast tumors with favorable outcome.
María Del Mar Noblejas-López, Cristina Nieto-Jiménez, +8 authors, Alberto Ocana.
Oncoimmunology, 2019 Oct 28; 8(10). PMID: 31646075    Free PMC article.
The MS-lincRNA landscape reveals a novel lincRNA BCLIN25 that contributes to tumorigenesis by upregulating ERBB2 expression via epigenetic modification and RNA-RNA interactions in breast cancer.
Shouping Xu, Hongbo Liu, +6 authors, Da Pang.
Cell Death Dis, 2019 Dec 06; 10(12). PMID: 31801944    Free PMC article.
Subtypes of Breast Cancer in Lao P.D.R.: A Study in a Limited-Resource Setting
Thitsamay Luangxay, Siriphone Virachith, +8 authors, Motoji Sawabe.
Asian Pac J Cancer Prev, 2019 Feb 26; 20(2). PMID: 30806064    Free PMC article.
Validation of the AJCC prognostic stage for HER2-positive breast cancer in the ShortHER trial.
Maria Vittoria Dieci, Giancarlo Bisagni, +29 authors, Pier Franco Conte.
BMC Med, 2019 Nov 22; 17(1). PMID: 31747948    Free PMC article.
An RB-1 loss of function gene signature as a tool to predict response to neoadjuvant chemotherapy plus anti-HER2 agents: a substudy of the NeoALTTO trial (BIG 1-06).
Emanuela Risi, Chiara Biagioni, +14 authors, Luca Malorni.
Ther Adv Med Oncol, 2019 Dec 20; 11. PMID: 31853266    Free PMC article.
Significant inter- and intra-laboratory variation in grading of invasive breast cancer: A nationwide study of 33,043 patients in the Netherlands.
Carmen van Dooijeweert, Paul J van Diest, +4 authors, Ivette A G Deckers.
Int J Cancer, 2019 Apr 13; 146(3). PMID: 30977119    Free PMC article.
Breast Cancer: Reimbursement Policies and Adoption of New Therapeutic Agents by National Health Systems.
Dario Trapani, Giuseppe Curigliano, Alexandru Eniu.
Breast Care (Basel), 2020 Jan 15; 14(6). PMID: 31933583    Free PMC article.
Review.
The Emerging Role of ESR1 Mutations in Luminal Breast Cancer as a Prognostic and Predictive Biomarker of Response to Endocrine Therapy.
Irene De Santo, Amelia McCartney, +2 authors, Luca Malorni.
Cancers (Basel), 2019 Dec 05; 11(12). PMID: 31795152    Free PMC article.
Review.
The Role of Multigene Assays in Addressing Treatment Heterogeneity for Breast Cancer.
Matti Aapro.
Biomed Hub, 2017 Nov 21; 2(Suppl 1). PMID: 31988928    Free PMC article.
Integration of Ki-67 index into AJCC 2018 staging provides additional prognostic information in breast tumours candidate for genomic profiling.
Elena Vissio, Jasna Metovic, +7 authors, Isabella Castellano.
Br J Cancer, 2019 Nov 30; 122(3). PMID: 31780778    Free PMC article.
Breast Conservation After Neoadjuvant Chemotherapy for Triple-Negative Breast Cancer: Surgical Results From the BrighTNess Randomized Clinical Trial.
Mehra Golshan, Sibylle Loibl, +12 authors, Michael Untch.
JAMA Surg, 2020 Jan 09; 155(3). PMID: 31913413    Free PMC article.
A systematic review and meta-analysis on the association of serum and tumor tissue iron and risk of breast cancer.
Akram Sanagoo, Faezeh Kiani, +4 authors, Majjid Dousti.
Caspian J Intern Med, 2020 Feb 12; 11(1). PMID: 32042380    Free PMC article.
Review.
Deep Learning vs. Radiomics for Predicting Axillary Lymph Node Metastasis of Breast Cancer Using Ultrasound Images: Don't Forget the Peritumoral Region.
Qiuchang Sun, Xiaona Lin, +5 authors, Zhi-Cheng Li.
Front Oncol, 2020 Feb 23; 10. PMID: 32083007    Free PMC article.
Comparison of 21-gene assay and St.Gallen International Expert Consensus in the treatment decision for patients with early invasive breast cancers.
Ming Luo, Fu Li, +2 authors, Jian Zeng.
Cancer Biol Ther, 2019 Oct 31; 21(2). PMID: 31663437    Free PMC article.
Adjuvant Anti-HER2 Therapy, Treatment-Related Amenorrhea, and Survival in Premenopausal HER2-Positive Early Breast Cancer Patients.
Matteo Lambertini, Christine Campbell, +19 authors, Evandro de Azambuja.
J Natl Cancer Inst, 2018 Jun 08; 111(1). PMID: 29878225    Free PMC article.
Disease-free survival as a surrogate for overall survival in patients with HER2-positive, early breast cancer in trials of adjuvant trastuzumab for up to 1 year: a systematic review and meta-analysis.
Everardo D Saad, Pierre Squifflet, +9 authors, Marc Buyse.
Lancet Oncol, 2019 Feb 03; 20(3). PMID: 30709633    Free PMC article.
Systematic Review.
Post-mastectomy Radiotherapy in T1-2 Breast Cancer Patients With One to Three Lymph Node Metastases: A Propensity Score Matching Analysis.
Maoshan Chen, Yunhui Huang, +4 authors, Lingmi Hou.
Front Oncol, 2020 Mar 03; 9. PMID: 32117784    Free PMC article.
Ki-67 assessment in early breast cancer: SAKK28/12 validation study on the IBCSG VIII and IBCSG IX cohort.
Zsuzsanna Varga, Qiyu Li, +7 authors, Thomas Ruhstaller.
Sci Rep, 2019 Sep 21; 9(1). PMID: 31537812    Free PMC article.
Metabolic Pathway Analysis and Effectiveness of Tamoxifen in Danish Breast Cancer Patients.
Thomas P Ahern, Lindsay J Collin, +16 authors, Deirdre Cronin-Fenton.
Cancer Epidemiol Biomarkers Prev, 2020 Jan 15; 29(3). PMID: 31932415    Free PMC article.
Real-life clinical pattern, management, and survival in Thai patients with early-stage or metastatic triple-negative breast cancer.
Vichien Srimuninnimit, Piti Pornpraserthsuk, +9 authors, Chaturong Tantimongkolsuk.
PLoS One, 2018 Dec 20; 13(12). PMID: 30566471    Free PMC article.
Radiologic complete response (rCR) in contrast-enhanced magnetic resonance imaging (CE-MRI) after neoadjuvant chemotherapy for early breast cancer predicts recurrence-free survival but not pathologic complete response (pCR).
Simon Peter Gampenrieder, Andreas Peer, +14 authors, Richard Greil.
Breast Cancer Res, 2019 Feb 02; 21(1). PMID: 30704493    Free PMC article.
Quality of life under extended continuous versus intermittent adjuvant letrozole in lymph node-positive, early breast cancer patients: the SOLE randomised phase 3 trial.
Karin Ribi, Weixiu Luo, +27 authors, SOLE Investigators.
Br J Cancer, 2019 Apr 11; 120(10). PMID: 30967649    Free PMC article.
Pyridoxine 5'-phosphate oxidase is correlated with human breast invasive ductal carcinoma development.
Weimin Ren, Wencai Guan, +2 authors, Guoxiong Xu.
Aging (Albany NY), 2019 Apr 16; 11(7). PMID: 30982780    Free PMC article.
Utility of Ki67 labeling index, cyclin D1 expression, and ER-activity level in postmenopausal ER-positive and HER2-negative breast cancer with neoadjuvant chemo-endocrine therapy.
Sasagu Kurozumi, Yuri Yamaguchi, +6 authors, Kenichi Inoue.
PLoS One, 2019 May 22; 14(5). PMID: 31112577    Free PMC article.
Targeting Immune-Related Biological Processes in Solid Tumors: We do Need Biomarkers.
Fabio Pagni, Elena Guerini-Rocco, +8 authors, Nicola Fusco.
Int J Mol Sci, 2019 Nov 07; 20(21). PMID: 31683784    Free PMC article.
Review.
Role of Bisphosphonates in Breast Cancer Therapy.
Hadar Goldvaser, Eitan Amir.
Curr Treat Options Oncol, 2019 Mar 16; 20(4). PMID: 30874905
Review.
Re: Expected Monetary Impact of Oncotype DX Score-Concordant Systemic Breast Cancer Therapy Based on the TAILORx Trial.
Paolo Giorgi Rossi, Eugenio Paci.
J Natl Cancer Inst, 2019 Jun 20; 112(3). PMID: 31214709    Free PMC article.
PTEN Expression as a Complementary Biomarker for Mismatch Repair Testing in Breast Cancer.
Gianluca Lopez, Marianna Noale, +12 authors, Nicola Fusco.
Int J Mol Sci, 2020 Feb 27; 21(4). PMID: 32098071    Free PMC article.
Decision-making of Adjuvant Chemotherapy for Breast Cancer Patients with Discordant Risk Classifications between Clinical-Pathological Factors and 21-gene Recurrence Score.
Weiqi Gao, Lin Lin, +2 authors, Kunwei Shen.
J Cancer, 2020 Mar 24; 11(9). PMID: 32201521    Free PMC article.
Concerning Dediu M, Zielinski A: A Proposal to Redefine Pathologic Complete Remission as Endpoint following Neoadjuvant Chemotherapy in Early Breast Cancer. Breast Care 2019; Doi 10.1159/000500620.
Michael Untch, Sibylle Loibl, Peter A Fasching.
Breast Care (Basel), 2020 Apr 02; 15(1). PMID: 32231504    Free PMC article.
360 Health Analysis (H360) - A Proposal for an Integrated Vision of Breast Cancer in Portugal.
Sara Coelho, Inês Brandão Rego, +5 authors, Luís Costa.
Eur J Breast Health, 2020 Apr 15; 16(2). PMID: 32285029    Free PMC article.
Review.
Early detection of changes in phospholipid metabolism during neoadjuvant chemotherapy in breast cancer patients using phosphorus magnetic resonance spectroscopy at 7T.
Erwin Krikken, Wybe J M van der Kemp, +5 authors, Jannie P Wijnen.
NMR Biomed, 2019 Mar 30; 32(6). PMID: 30924571    Free PMC article.
Prognostic significance of α- and β2-adrenoceptor gene expression in breast cancer patients.
Ezequiel Mariano Rivero, Leandro Marcelo Martinez, +3 authors, Isabel Alicia Lüthy.
Br J Clin Pharmacol, 2019 Jun 21; 85(9). PMID: 31218733    Free PMC article.
PTHrP, A Biomarker for CNS Metastasis in Triple-Negative Breast Cancer and Selection for Adjuvant Chemotherapy in Node-Negative Disease.
Gloria Assaker, Anne Camirand, +7 authors, Siham Sabri.
JNCI Cancer Spectr, 2020 Apr 17; 4(1). PMID: 32296756    Free PMC article.
Integrating Biological Advances Into the Clinical Management of Breast Cancer Related Lymphedema.
Marco Invernizzi, Gianluca Lopez, +8 authors, Nicola Fusco.
Front Oncol, 2020 Apr 18; 10. PMID: 32300557    Free PMC article.
Review.
Role of Magnetic Resonance Imaging in the Evaluation of Breast Cancer Response to Neoadjuvant Chemotherapy.
Giorgia Pasquero, Alessandra Surace, +6 authors, Maria Grazia Baù.
In Vivo, 2020 Mar 01; 34(2). PMID: 32111803    Free PMC article.
Ki-67 index, progesterone receptor expression, histologic grade and tumor size in predicting breast cancer recurrence risk: A consecutive cohort study.
Yanna Zhang, Yidong Zhou, +2 authors, Qiang Sun.
Cancer Commun (Lond), 2020 Apr 16; 40(4). PMID: 32291973    Free PMC article.
Subtype-Guided 18 F-FDG PET/CT in Tailoring Axillary Surgery Among Patients with Node-Positive Breast Cancer Treated with Neoadjuvant Chemotherapy: A Feasibility Study.
Siyu Wu, Yujie Wang, +8 authors, Guangyu Liu.
Oncologist, 2020 Apr 17; 25(4). PMID: 32297448    Free PMC article.
Overview of multiplex immunohistochemistry/immunofluorescence techniques in the era of cancer immunotherapy.
Wei Chang Colin Tan, Sanjna Nilesh Nerurkar, +6 authors, Tony Kiat Hon Lim.
Cancer Commun (Lond), 2020 Apr 18; 40(4). PMID: 32301585    Free PMC article.
Review.
Paclitaxel/IR1061-Co-Loaded Protein Nanoparticle for Tumor-Targeted and pH/NIR-II-Triggered Synergistic Photothermal-Chemotherapy.
Li He, Fangzhen Qing, Maode Li, Daitian Lan.
Int J Nanomedicine, 2020 Apr 21; 15. PMID: 32308385    Free PMC article.
Axillary web syndrome among Chilean women with breast cancer: incidence and possible predisposing factors.
Karol Ramírez-Parada, Diana Garay-Acevedo, +5 authors, Rodrigo Fernández-Verdejo.
Support Care Cancer, 2019 Nov 27; 28(6). PMID: 31768730
Prediction of Pathologic Complete Response by Ultrasonography and Magnetic Resonance Imaging After Neoadjuvant Chemotherapy in Patients with Breast Cancer.
Kai Zhang, Jiawei Li, Qian Zhu, Cai Chang.
Cancer Manag Res, 2020 May 06; 12. PMID: 32368138    Free PMC article.
Recent advances in understanding breast cancer and emerging therapies with a focus on luminal and triple-negative breast cancer.
Georges El Hachem, Andrea Gombos, Ahmad Awada.
F1000Res, 2019 May 10; 8. PMID: 31069063    Free PMC article.
Review.
Prediction of biological characteristics of breast cancer using dual-phase FDG PET/CT.
Shinsuke Sasada, Norio Masumoto, +6 authors, Morihito Okada.
Eur J Nucl Med Mol Imaging, 2019 Jan 17; 46(4). PMID: 30648199
Tumour characteristics and survivorship in a cohort of breast cancer: the MCC-Spain study.
Inés Gómez-Acebo, Trinidad Dierssen-Sotos, +22 authors, Javier Llorca.
Breast Cancer Res Treat, 2020 May 02; 181(3). PMID: 32356254    Free PMC article.
Tamoxifen Exposure during Pregnancy: A Systematic Review and Three More Cases.
Barbara Buonomo, Antonella Brunello, +4 authors, Fedro Alessandro Peccatori.
Breast Care (Basel), 2020 May 14; 15(2). PMID: 32398983    Free PMC article.
Review.
HER2-enriched subtype and pathological complete response in HER2-positive breast cancer: A systematic review and meta-analysis.
Francesco Schettini, Tomás Pascual, +25 authors, Aleix Prat.
Cancer Treat Rev, 2020 Jan 31; 84. PMID: 32000054    Free PMC article.
Systematic Review.
Cancer Classification at the Crossroads.
Antonino Carbone.
Cancers (Basel), 2020 Apr 25; 12(4). PMID: 32326638    Free PMC article.
Grading variation in 2,934 patients with ductal carcinoma in situ of the breast: the effect of laboratory- and pathologist-specific feedback reports.
Carmen van Dooijeweert, Paul J van Diest, +2 authors, Ivette A G Deckers.
Diagn Pathol, 2020 May 13; 15(1). PMID: 32393303    Free PMC article.
Dynamic FDG-PET/CT in the Initial Staging of Primary Breast Cancer: Clinicopathological Correlations.
Kornélia Kajáry, Zsolt Lengyel, +3 authors, Tímea Tőkés.
Pathol Oncol Res, 2019 Apr 04; 26(2). PMID: 30941738    Free PMC article.
Low Overall Survival in Women With De Novo Metastatic Breast Cancer: Does This Reflect Tumor Biology or a Lack of Access to Health Care?
Leonardo R Soares, Ruffo Freitas-Junior, +3 authors, José C Oliveira.
JCO Glob Oncol, 2020 Apr 30; 6. PMID: 32348160    Free PMC article.
CircRNA_103809 Suppresses the Proliferation and Metastasis of Breast Cancer Cells by Sponging MicroRNA-532-3p (miR-532-3p).
Minfeng Liu, Can Luo, +4 authors, Zhaoze Guo.
Front Genet, 2020 Jun 06; 11. PMID: 32499818    Free PMC article.
An Ultrasensitive Routine LC-MS/MS Method for Estradiol and Estrone in the Clinically Relevant Sub-Picomolar Range.
Bjørn-Erik Bertelsen, Ralf Kellmann, +5 authors, Bjørg Almås.
J Endocr Soc, 2020 Jun 06; 4(6). PMID: 32500111    Free PMC article.
Does dose-dense neoadjuvant chemotherapy have clinically significant prognostic value in breast cancer?: A meta-analysis of 3,724 patients.
Yuqin Ding, Kaijing Ding, +3 authors, Xiaowen Ding.
PLoS One, 2020 May 30; 15(5). PMID: 32470093    Free PMC article.
Prognostic impact of ACTN4 gene copy number alteration in hormone receptor-positive, HER2-negative, node-negative invasive breast carcinoma.
Teppei Sugano, Masayuki Yoshida, +7 authors, Tesshi Yamada.
Br J Cancer, 2020 Apr 09; 122(12). PMID: 32265507    Free PMC article.
Patients' perceptions of 70-gene signature testing: commonly changing the initial inclination to undergo or forego chemotherapy and reducing decisional conflict.
Julia E C van Steenhoven, Bianca M den Dekker, +6 authors, Thijs van Dalen.
Breast Cancer Res Treat, 2020 May 21; 182(1). PMID: 32430679    Free PMC article.
EndoPredict® in early hormone receptor-positive, HER2-negative breast cancer.
K Almstedt, S Mendoza, +9 authors, M Schmidt.
Breast Cancer Res Treat, 2020 May 22; 182(1). PMID: 32436145    Free PMC article.
Association between initiation of adjuvant chemotherapy beyond 30 days after surgery and overall survival among patients with triple-negative breast cancer.
Erik Heeg, Perla J Marang-van de Mheen, +5 authors, Marie-Jeanne T F D Vrancken Peeters.
Int J Cancer, 2019 Nov 14; 147(1). PMID: 31721193    Free PMC article.
Variability in hospital treatment costs: a time-driven activity-based costing approach for early-stage invasive breast cancer patients.
Erin Roman, Brecht Cardoen, Jan Decloedt, Filip Roodhooft.
BMJ Open, 2020 Jul 10; 10(7). PMID: 32641325    Free PMC article.
Phase III Randomized Trial of Bisphosphonates as Adjuvant Therapy in Breast Cancer: S0307.
Julie R Gralow, William E Barlow, +20 authors, Gabriel N Hortobagyi.
J Natl Cancer Inst, 2019 Nov 07; 112(7). PMID: 31693129    Free PMC article.
Radiation Boost After Adjuvant Whole Breast Radiotherapy: Does Evidence Support Practice for Close Margin and Altered Fractionation?
Stephanie Gulstene, Hamid Raziee.
Front Oncol, 2020 Jul 17; 10. PMID: 32670865    Free PMC article.
Review.
A prospective, randomized study of Toremifene vs. tamoxifen for the treatment of premenopausal breast cancer: safety and genital symptom analysis.
Jin Hong, Jiahui Huang, +10 authors, Kunwei Shen.
BMC Cancer, 2020 Jul 18; 20(1). PMID: 32677982    Free PMC article.
Prognostic potential of automated Ki67 evaluation in breast cancer: different hot spot definitions versus true global score.
Stephanie Robertson, Balazs Acs, Michael Lippert, Johan Hartman.
Breast Cancer Res Treat, 2020 Jun 24; 183(1). PMID: 32572716    Free PMC article.
Breast cancer surveillance for BRCA1/2 mutation carriers - is "early detection" early enough?
Rinat Bernstein-Molho, Bella Kaufman, +5 authors, Eitan Friedman.
Breast, 2019 Nov 25; 49. PMID: 31760168    Free PMC article.
Risk stratification in luminal-type breast cancer: Comparison of Ki-67 with EndoPredict test results.
Aurelia Noske, Sophie-Isabelle Anders, +6 authors, Evelyn Klein.
Breast, 2019 Dec 02; 49. PMID: 31786414    Free PMC article.
Expression of tumor-associated antigens in breast cancer subtypes.
Giuseppe Curigliano, Vincenzo Bagnardi, +7 authors, Giuseppe Viale.
Breast, 2019 Dec 24; 49. PMID: 31869767    Free PMC article.
Targeted next-generation sequencing identifies genomic abnormalities potentially driving the prognosis of early-stage invasive lobular breast carcinoma patients stratified according to a validated clinico-pathological model.
Luisa Carbognin, Michele Simbolo, +19 authors, Emilio Bria.
Breast, 2020 Feb 07; 50. PMID: 32028173    Free PMC article.
The requirements of a specialist breast centre.
Laura Biganzoli, Fatima Cardoso, +24 authors, Philip Poortmans.
Breast, 2020 Mar 29; 51. PMID: 32217457    Free PMC article.
Do YOU know the Ki-67 index of your breast cancer patients? Knowledge of your institution's Ki-67 index distribution and its robustness is essential for decision-making in early breast cancer.
Angela Fischer Maranta, Simon Broder, +4 authors, Thomas Ruhstaller.
Breast, 2020 Apr 18; 51. PMID: 32302928    Free PMC article.
Prospective observational study on the impact of the 21-gene assay on treatment decisions and resources optimization in breast cancer patients in Lombardy: The BONDX study.
Alberto Zambelli, Edda Simoncini, +11 authors, Carlo Tondini.
Breast, 2020 Apr 24; 52. PMID: 32325372    Free PMC article.
Estimation of historical control rate for a single arm de-escalation study - Application to the POSITIVE trial.
Zhuoxin Sun, Samuel M Niman, +9 authors, POSITIVE Steering Committee.
Breast, 2020 Jun 15; 53. PMID: 32535486    Free PMC article.
CHARACTERISTICS AND PROGNOSIS OF TRIPLE-NEGATIVE BREAST CANCER PATIENTS: A CROATIAN SINGLE INstitution RETROSPECTIVE COHORT STUDY.
Ana Tečić Vuger, Robert Šeparović, +6 authors, Damir Vrbanec.
Acta Clin Croat, 2020 Jul 30; 59(1). PMID: 32724280    Free PMC article.
Non-Invasive Assessment of Breast Cancer Molecular Subtypes with Multiparametric Magnetic Resonance Imaging Radiomics.
Doris Leithner, Marius E Mayerhoefer, +4 authors, Katja Pinker.
J Clin Med, 2020 Jun 18; 9(6). PMID: 32545851    Free PMC article.
Controlling technical variation amongst 6693 patient microarrays of the randomized MINDACT trial.
Laurent Jacob, Anke Witteveen, +17 authors, Annuska Glas.
Commun Biol, 2020 Jul 29; 3(1). PMID: 32719399    Free PMC article.
Quantifying the Mitigating Effects of Whole-Breast Radiotherapy and Systemic Treatments on Regional Recurrence Incidence Among Breast Cancer Patients.
Julia E C van Steenhoven, Anne Kuijer, +7 authors, Thijs van Dalen.
Ann Surg Oncol, 2020 Mar 22; 27(9). PMID: 32198570    Free PMC article.
Personalised medicine and the decision to withhold chemotherapy in early breast cancer with intermediate risk of recurrence - a systematic review and meta-analysis.
Susanna M Wallerstedt, Astrid Nilsson Ek, +3 authors, Barbro Linderholm.
Eur J Clin Pharmacol, 2020 Jun 07; 76(9). PMID: 32504183    Free PMC article.
Review.
Endocrine Therapy Plus Anti-HER2 Therapy as Adjuvant Systemic Therapy for Luminal HER2-Positive Breast Cancer: An Analysis of the National Cancer Database.
Zeina A Nahleh, Elizabeth B Elimimian, +3 authors, Cassann N Blake.
Breast Cancer (Auckl), 2020 Aug 22; 14. PMID: 32821110    Free PMC article.
Optimizing MR-Guided Radiotherapy for Breast Cancer Patients.
Maureen L Groot Koerkamp, Jeanine E Vasmel, +16 authors, Anna M Kirby.
Front Oncol, 2020 Aug 28; 10. PMID: 32850318    Free PMC article.
Review.
The combination of platelet count and lymphocyte to monocyte ratio is a prognostic factor in patients with resected breast cancer.
Yunfu Deng, Wen Li, +5 authors, Qinghua Zhou.
Medicine (Baltimore), 2020 May 03; 99(18). PMID: 32358341    Free PMC article.
Prediction of nodal staging in breast cancer patients with 1-2 sentinel nodes in the Z0011 era.
Fabio Corsi, Luca Sorrentino, +4 authors, Marta Truffi.
Medicine (Baltimore), 2020 Sep 03; 99(35). PMID: 32871890    Free PMC article.
Association of higher axillary pathologic complete response rate with breast pathologic complete response after neoadjuvant chemotherapy.
Jiujun Zhu, Jianbin Li, +8 authors, Zhenzhen Liu.
Ann Transl Med, 2020 Sep 22; 8(16). PMID: 32953792    Free PMC article.
Simulation modeling approaches to answer clinically relevant questions in breast cancer low-risk populations.
Ana Calin, Miguel Martin, Sara Lopez-Tarruella.
Ann Transl Med, 2019 Jan 08; 6(Suppl 1). PMID: 30613655    Free PMC article.
Emerging Opportunities of Radiotherapy Combined With Immunotherapy in the Era of Breast Cancer Heterogeneity.
Pelagia G Tsoutsou, Khalil Zaman, +3 authors, Marie-Catherine Vozenin.
Front Oncol, 2019 Jan 09; 8. PMID: 30619749    Free PMC article.
Review.
High Frequency of ERBB2 Activating Mutations in Invasive Lobular Breast Carcinoma with Pleomorphic Features.
Juan Manuel Rosa-Rosa, Tamara Caniego-Casas, +8 authors, José Palacios.
Cancers (Basel), 2019 Jan 16; 11(1). PMID: 30641862    Free PMC article.
HR-MAS NMR Based Quantitative Metabolomics in Breast Cancer.
Mikheil Gogiashvili, Jessica Nowacki, +3 authors, Karolina Edlund.
Metabolites, 2019 Jan 27; 9(2). PMID: 30678289    Free PMC article.
Review.
Breast Cancer Systemic Treatments and Upper Limb Lymphedema: A Risk-Assessment Platform Encompassing Tumor-Specific Pathological Features Reveals the Potential Role of Trastuzumab.
Marco Invernizzi, Anna Michelotti, +8 authors, Nicola Fusco.
J Clin Med, 2019 Jan 27; 8(2). PMID: 30682851    Free PMC article.
Update of the American Society of Breast Surgeons Toolbox to address the lumpectomy reoperation epidemic.
Maureen P McEvoy, Jeffrey Landercasper, Himani R Naik, Sheldon Feldman.
Gland Surg, 2019 Jan 29; 7(6). PMID: 30687627    Free PMC article.
Review.
Primary medical therapy and breast conservation treatment: the medical oncology perspective.
Nan Soon Wong.
Gland Surg, 2019 Jan 29; 7(6). PMID: 30687629    Free PMC article.
Review.
Triple-negative breast cancer: the reality in Chile and in Latin America.
Christian Caglevic, Jaime Anabalón, +6 authors, Mauricio Mahave.
Ecancermedicalscience, 2019 Feb 23; 13. PMID: 30792810    Free PMC article.
Review.
Clinical validation of Ki67 by quantitative reverse transcription-polymerase chain reaction (RT-PCR) in HR+/HER2- early breast cancer.
Weiqi Gao, Jiayi Wu, +4 authors, Ou Huang.
J Cancer, 2019 Mar 12; 10(5). PMID: 30854118    Free PMC article.
The distinct clinicopathological and prognostic implications of PIK3CA mutations in breast cancer patients from Central China.
Haibo Wu, Wei Wang, +8 authors, Wenchu Lin.
Cancer Manag Res, 2019 Mar 14; 11. PMID: 30863158    Free PMC article.
Ovarian Function and Fertility Preservation in Breast Cancer: Should Gonadotropin-Releasing Hormone Agonist be administered to All Premenopausal Patients Receiving Chemotherapy?
Matteo Lambertini, François Richard, +2 authors, Cynthia Villarreal-Garza.
Clin Med Insights Reprod Health, 2019 Mar 20; 13. PMID: 30886529    Free PMC article.
Review.
The effect of neoadjuvant platinum-based chemotherapy in BRCA mutated triple negative breast cancers -systematic review and meta-analysis.
Olga Caramelo, Cristina Silva, +2 authors, Teresa Almeida-Santos.
Hered Cancer Clin Pract, 2019 Apr 10; 17. PMID: 30962858    Free PMC article.
Review.
A high absolute lymphocyte count predicts a poor prognosis in HER-2- positive breast cancer patients treated with trastuzumab.
Jin Hong, Xiaosong Chen, +10 authors, Kunwei Shen.
Cancer Manag Res, 2019 May 23; 11. PMID: 31114373    Free PMC article.
Non-hormonal strategies for managing menopausal symptoms in cancer survivors: an update.
Nicoletta Biglia, Valentina E Bounous, +3 authors, Anna Maria Paoletti.
Ecancermedicalscience, 2019 May 28; 13. PMID: 31123492    Free PMC article.
Review.
Should a Multigene Signature be Used in all Luminal Early Breast Cancers.
Nawale Hajjaji, Yves Marie Robin, Jacques Bonneterre.
Front Oncol, 2019 Jun 20; 9. PMID: 31214499    Free PMC article.
High expression of metabolic enzyme PFKFB4 is associated with poor prognosis of operable breast cancer.
Ling Yao, Lei Wang, +2 authors, Zhi-Ming Shao.
Cancer Cell Int, 2019 Jun 28; 19. PMID: 31244553    Free PMC article.
Mismatch Repair Protein Loss as a Prognostic and Predictive Biomarker in Breast Cancers Regardless of Microsatellite Instability.
Nicola Fusco, Gianluca Lopez, +13 authors, Silvano Bosari.
JNCI Cancer Spectr, 2019 Jul 31; 2(4). PMID: 31360876    Free PMC article.
Deescalating Adjuvant Trastuzumab in HER2-Positive Early-Stage Breast Cancer: A Systemic Review and Meta-Analysis.
Hadar Goldvaser, Yasmin Korzets, +5 authors, Eitan Amir.
JNCI Cancer Spectr, 2019 Jul 31; 3(2). PMID: 31360906    Free PMC article.
Clinicopathological and epidemiological significance of breast cancer subtype reclassification based on p53 immunohistochemical expression.
Mustapha Abubakar, Changyuan Guo, +9 authors, Xiaohong R Yang.
NPJ Breast Cancer, 2019 Aug 03; 5. PMID: 31372496    Free PMC article.
Inclusion of Platinum Agents in Neoadjuvant Chemotherapy Regimens for Triple-Negative Breast Cancer Patients: Development of GRADE (Grades of Recommendation, Assessment, Development and Evaluation) Recommendation by the Italian Association of Medical Oncology (AIOM).
Maria Vittoria Dieci, Lucia Del Mastro, +14 authors, Stefania Gori.
Cancers (Basel), 2019 Aug 11; 11(8). PMID: 31398896    Free PMC article.
Clinical and pathological factors predictive of response to neoadjuvant chemotherapy in breast cancer: A single center experience.
Salvatore Del Prete, Michele Caraglia, +11 authors, Raffaele Addeo.
Oncol Lett, 2019 Sep 14; 18(4). PMID: 31516598    Free PMC article.
Breast Cancer: global quality care optimizing care delivery with existing financial and personnel resources.
Didier Verhoeven, Claudia Allemani, +3 authors, Benjamin Anderson.
ESMO Open, 2020 Sep 09; 4(Suppl 2). PMID: 32895233    Free PMC article.
Review.
Genomic Signatures in Luminal Breast Cancer.
Julian Puppe, Tabea Seifert, +3 authors, Wolfram Malter.
Breast Care (Basel), 2020 Sep 29; 15(4). PMID: 32982645    Free PMC article.
Review.
Do we still need breast cancer screening in the era of targeted therapies and precision medicine?
Rubina Manuela Trimboli, Paolo Giorgi Rossi, +4 authors, Francesco Sardanelli.
Insights Imaging, 2020 Sep 26; 11(1). PMID: 32975658    Free PMC article.
Review.
Assessment of tumour proliferation by use of the mitotic activity index, and Ki67 and phosphohistone H3 expression, in early-stage luminal breast cancer.
Julia E C van Steenhoven, Anne Kuijer, +4 authors, Paul J van Diest.
Histopathology, 2020 Jun 20; 77(4). PMID: 32557844    Free PMC article.
Guidance and Standards for Breast Cancer Care in Europe.
Rudy Leon De Wilde, Rajesh Devassy, +3 authors, Cristina Cezar.
J Obstet Gynaecol India, 2020 Oct 13; 70(5). PMID: 33041548    Free PMC article.
Review.
The comparison of the anatomic stage and pathological prognostic stage according to the AJCC 8th edition for the prognosis in Japanese breast cancer patients: data from a single institution.
Eriko Tokunaga, Hideki Ijichi, +9 authors, Masahiro Okamoto.
Breast Cancer, 2020 May 31; 27(6). PMID: 32472474    Free PMC article.
Retrospective Comparison of Contrast-Enhanced Spectral Mammography with Digital Mammography in Assessing Tumor Size in 668 Cases of Breast Cancer.
Andrzej Lorek, Katarzyna Steinhof-Radwańska, +5 authors, Zoran Stojčev.
Med Sci Monit, 2020 Oct 01; 26. PMID: 32994388    Free PMC article.
Timing of Chemotherapy and Radiotherapy Following Breast-Conserving Surgery for Early-Stage Breast Cancer: A Retrospective Analysis.
Si-Ye Chen, Yu Tang, +17 authors, Ye-Xiong Li.
Front Oncol, 2020 Oct 20; 10. PMID: 33072604    Free PMC article.
Beyond Chemotherapies: Recent Strategies in Breast Cancer Treatment.
Arthur Foulon, Pierrick Theret, Lise Rodat-Despoix, Philippe Kischel.
Cancers (Basel), 2020 Sep 20; 12(9). PMID: 32947780    Free PMC article.
Review.
The Survival Outcomes of T1aN0M0 Triple-Negative Breast Cancer With Adjuvant Chemotherapy.
Wen-Fen Fu, Qing-Xia Chen, +2 authors, Chuan-Gui Song.
Front Oncol, 2020 Oct 27; 10. PMID: 33102205    Free PMC article.
Neoadjuvant chemotherapy: practice and thinking for Chinese patients with early breast cancer.
Xue-Fei Wang, Song-Jie Shen, +4 authors, Qiang Sun.
Chin Med J (Engl), 2020 Aug 10; 133(19). PMID: 32769502    Free PMC article.
The Case to Case Comparison of Hormone Receptors and HER2 Status between Primary Breast Cancer and Synchronous Axillary Lymph Node Metastasis.
Sasithorn Sujarittanakarn, Wanwisa Himakhun, Worawarn Worasawate, Wilairat Prasert.
Asian Pac J Cancer Prev, 2020 Jun 28; 21(6). PMID: 32592349    Free PMC article.
Validation of Clinical Treatment Score post-5 years (CTS5) risk stratification in premenopausal breast cancer patients and Ki-67 labelling index.
Janghee Lee, Chihwan Cha, +9 authors, Joon Jeong.
Sci Rep, 2020 Oct 10; 10(1). PMID: 33033359    Free PMC article.
Efficacy and Safety of Fulvestrant 500mg in Hormone-receptor Positive Human Epidermal Receptor 2 Negative Advanced Breast Cancer: A Real-world Study in China.
Wen Lei, Huiping Li, +5 authors, Hanfang Jiang.
J Cancer, 2020 Oct 14; 11(22). PMID: 33046982    Free PMC article.
Development and validation of a novel stem cell subtype for bladder cancer based on stem genomic profiling.
Chaozhi Tang, Jiakang Ma, Xiuli Liu, Zhengchun Liu.
Stem Cell Res Ther, 2020 Oct 30; 11(1). PMID: 33115513    Free PMC article.
Platinum-based neoadjuvant chemotherapy for triple-negative breast cancer: a systematic review and meta-analysis.
Zhen-Yu Li, Zhen Zhang, +2 authors, Sha-Sha Ren.
J Int Med Res, 2020 Oct 27; 48(10). PMID: 33100072    Free PMC article.
Evaluation of Adjuvant Treatments for T1 N0 M0 Triple-Negative Breast Cancer.
Zhen Zhai, Yi Zheng, +12 authors, Zhijun Dai.
JAMA Netw Open, 2020 Nov 20; 3(11). PMID: 33211105    Free PMC article.
Insights for the application of TILs and AR in the treatment of TNBC in routine clinical practice.
Agnese Losurdo, Rita De Sanctis, +9 authors, Armando Santoro.
Sci Rep, 2020 Nov 20; 10(1). PMID: 33208857    Free PMC article.
Therapeutic Strategies for the Management of Hormone Receptor-Positive, Human Epidermal Growth Factor Receptor 2-Positive (HR+/HER2+) Breast Cancer: A Review of the Current Literature.
Eirini Thanopoulou, Leila Khader, +5 authors, Valentina Guarneri.
Cancers (Basel), 2020 Nov 14; 12(11). PMID: 33182657    Free PMC article.
Review.
Patient interactive digital support for women with adjuvant endocrine therapy in order to increase compliance and quality of life.
Jenny Bergqvist, Staffan Lundström, Yvonne Wengström.
Support Care Cancer, 2020 May 15; 29(1). PMID: 32405965    Free PMC article.
Comparing protein and mRNA expressions of the human epidermal growth factor receptor family in estrogen receptor-positive breast cancer.
Sasagu Kurozumi, Yuri Yamaguchi, +6 authors, Ken Shirabe.
Med Mol Morphol, 2018 Sep 28; 52(2). PMID: 30259117
SEOM clinical guidelines in early stage breast cancer (2018).
F Ayala de la Peña, R Andrés, +7 authors, E Ciruelos.
Clin Transl Oncol, 2018 Nov 18; 21(1). PMID: 30443868    Free PMC article.
Characteristics of adverse events of endocrine therapies among older patients with breast cancer.
Naoko Honma, Masujiro Makita, +6 authors, Shinji Ohno.
Support Care Cancer, 2019 Feb 08; 27(10). PMID: 30729298
Higher axillary lymph node metastasis burden in breast cancer patients with positive preoperative node biopsy: may not be appropriate to receive sentinel lymph node biopsy in the post-ACOSOG Z0011 trial era.
Yue Liang, Xiaosong Chen, +9 authors, Kunwei Shen.
World J Surg Oncol, 2019 Feb 23; 17(1). PMID: 30786903    Free PMC article.
The estrogen receptor coactivator AIB1 is a new putative prognostic biomarker in ER-positive/HER2-negative invasive lobular carcinoma of the breast.
Ulrik Narbe, Martin Sjöström, +7 authors, Mårten Fernö.
Breast Cancer Res Treat, 2019 Feb 24; 175(2). PMID: 30796653    Free PMC article.
Minimal prognostic significance of sentinel lymph node metastasis in patients with cT1-2 and cN0 breast cancer.
Hideo Shigematsu, Mai Nishina, +2 authors, Shinji Ozaki.
World J Surg Oncol, 2019 Feb 25; 17(1). PMID: 30797231    Free PMC article.
[Update of the German S3 breast cancer guideline : What is new for pathologists?]
A Lebeau, C Denkert, +2 authors, A Wöckel.
Pathologe, 2019 Mar 09; 40(2). PMID: 30847505
Higher ER load is not associated with better outcome in stage 1-3 breast cancer: a descriptive overview of quantitative HR analysis in operable breast cancer.
I Noordhoek, A F de Groot, +3 authors, J R Kroep.
Breast Cancer Res Treat, 2019 Apr 19; 176(1). PMID: 30997625    Free PMC article.
Review.
HER2+ breast cancer treatment and cardiotoxicity: monitoring and management.
Guy Jerusalem, Patrizio Lancellotti, Sung-Bae Kim.
Breast Cancer Res Treat, 2019 Jun 06; 177(2). PMID: 31165940    Free PMC article.
Review.
The impact of age on the risk of ipsilateral breast tumor recurrence after breast-conserving therapy in breast cancer patients with a > 5 mm margin treated without boost irradiation.
Yuka Ono, Michio Yoshimura, +6 authors, Takashi Mizowaki.
Radiat Oncol, 2019 Jul 12; 14(1). PMID: 31291997    Free PMC article.
The Role of Exosomal MicroRNAs in the Tumor Microenvironment of Breast Cancer.
Qingqing Liu, Fu Peng, Jianping Chen.
Int J Mol Sci, 2019 Aug 10; 20(16). PMID: 31395836    Free PMC article.
Review.
Combined expression levels of KDM2A and KDM2B correlate with nucleolar size and prognosis in primary breast carcinomas.
Igor De Nicola, Ania Naila Guerrieri, +4 authors, Lorenzo Montanaro.
Histol Histopathol, 2020 Sep 10; 35(10). PMID: 32901907
Postmenopausal Breast Cancer in Women, Clinical and Epidemiological Factors Related to the Molecular Subtype: A Retrospective Cohort Study in a Single Institution for 13 Years. Follow-Up Data.
Cristina Marinela Oprean, Serban Mircea Negru, +5 authors, Alis Dema.
Int J Environ Res Public Health, 2020 Dec 02; 17(23). PMID: 33255341    Free PMC article.
Mammographic tumour appearance is related to clinicopathological factors and surrogate molecular breast cancer subtype.
Li Sturesdotter, Malte Sandsveden, +3 authors, Hanna Sartor.
Sci Rep, 2020 Dec 02; 10(1). PMID: 33257731    Free PMC article.
Chemotherapy induces dynamic immune responses in breast cancers that impact treatment outcome.
Yeon Hee Park, Samir Lal, +28 authors, Zhengyan Kan.
Nat Commun, 2020 Dec 04; 11(1). PMID: 33268821    Free PMC article.
Co-localization of CD169+ macrophages and cancer cells in lymph node metastases of breast cancer patients is linked to improved prognosis and PDL1 expression.
Frida Björk Gunnarsdottir, Nathalie Auoja, +3 authors, Karin Leandersson.
Oncoimmunology, 2020 Dec 11; 9(1). PMID: 33299660    Free PMC article.
DKC1 Overexpression Induces a More Aggressive Cellular Behavior and Increases Intrinsic Ribosomal Activity in Immortalized Mammary Gland Cells.
Ania Naila Guerrieri, Federico Zacchini, +9 authors, Lorenzo Montanaro.
Cancers (Basel), 2020 Dec 02; 12(12). PMID: 33255756    Free PMC article.
An Improved, Assay Platform Agnostic, Absolute Single Sample Breast Cancer Subtype Classifier.
Mi-Kyoung Seo, Soonmyung Paik, Sangwoo Kim.
Cancers (Basel), 2020 Dec 02; 12(12). PMID: 33255759    Free PMC article.
Mechanisms of Resistance to Chemotherapy in Breast Cancer and Possible Targets in Drug Delivery Systems.
Patrícia de Faria Lainetti, Antonio Fernando Leis-Filho, +2 authors, Carlos Eduardo Fonseca-Alves.
Pharmaceutics, 2020 Dec 16; 12(12). PMID: 33316872    Free PMC article.
Review.
Avoiding Axillary Sentinel Lymph Node Biopsy after Neoadjuvant Systemic Therapy in Breast Cancer: Rationale for the Prospective, Multicentric EUBREAST-01 Trial.
Toralf Reimer, Aenne Glass, +2 authors, Oreste D Gentilini.
Cancers (Basel), 2020 Dec 16; 12(12). PMID: 33317077    Free PMC article.
Tumour-infiltrating lymphocytes as a prognostic and tamoxifen predictive marker in premenopausal breast cancer: data from a randomised trial with long-term follow-up.
Christine Lundgren, Pär-Ola Bendahl, +6 authors, Lisa Rydén.
Breast Cancer Res, 2020 Dec 29; 22(1). PMID: 33357231    Free PMC article.
Prognostic value of the 21-gene recurrence score in ER-positive, HER2-negative, node-positive breast cancer was similar in node-negative diseases: a single-center study of 800 patients.
Jiayi Wu, Weiqi Gao, +9 authors, Kunwei Shen.
Front Med, 2020 Dec 29;. PMID: 33367943
Economic evaluation of adjuvant trastuzumab emtansine in patients with HER2-positive early breast cancer and residual invasive disease after neoadjuvant taxane and trastuzumab-based treatment in Canada.
T Younis, A Lee, +4 authors, G S Jhuti.
Curr Oncol, 2021 Jan 01; 27(6). PMID: 33380873    Free PMC article.
Higher efficacy and reduced adverse reactions in neoadjuvant chemotherapy for breast cancer by using pegylated liposomal doxorubicin compared with pirarubicin.
Weifang Liu, Wei Chen, +12 authors, Aiping Shi.
Sci Rep, 2021 Jan 10; 11(1). PMID: 33420241    Free PMC article.
Breast Cancer Recurrence in the Nipple-Areola Complex After Nipple-Sparing Mastectomy With Immediate Breast Reconstruction for Invasive Breast Cancer.
Zhen-Yu Wu, Hee-Jeong Kim, +10 authors, BeomSeok Ko.
JAMA Surg, 2019 Aug 29; 154(11). PMID: 31461141    Free PMC article.
Prognostic Score-Based Stratification Analysis Reveals Universal Benefits of Radiotherapy on Lowering the Risk of Ipsilateral Breast Event for Ductal Carcinoma In Situ Patients with Different Risk Levels.
Libo Yang, Dongli Lu, +5 authors, Hong Bu.
Ann Surg Oncol, 2020 Aug 15; 28(2). PMID: 32794031
ENPP4 overexpression is associated with no recovery from Barrett's esophagus.
Jian Wang, Jiabo Di, Guiqi Wang.
Int J Clin Exp Pathol, 2021 Jan 12; 13(12). PMID: 33425094    Free PMC article.
Diagnosis of ductal carcinoma in situ in an era of de-escalation of therapy.
Stuart J Schnitt.
Mod Pathol, 2020 Sep 11; 34(Suppl 1). PMID: 32908254
Review.
Genome-wide association study identifies 32 novel breast cancer susceptibility loci from overall and subtype-specific analyses.
Haoyu Zhang, Thomas U Ahearn, +273 authors, Montserrat García-Closas.
Nat Genet, 2020 May 20; 52(6). PMID: 32424353    Free PMC article.
The role of capecitabine-based neoadjuvant and adjuvant chemotherapy in early-stage triple-negative breast cancer: a systematic review and meta-analysis.
Xingfa Huo, Jinming Li, +5 authors, Jiuda Zhao.
BMC Cancer, 2021 Jan 21; 21(1). PMID: 33468087    Free PMC article.
The NeST (Neoadjuvant systemic therapy in breast cancer) study: National Practice Questionnaire of United Kingdom multi-disciplinary decision making.
I Whitehead, G W Irwin, +17 authors, NeST Study Research Collaborative.
BMC Cancer, 2021 Jan 24; 21(1). PMID: 33482770    Free PMC article.
Imaging features of breast cancer molecular subtypes: state of the art.
Nariya Cho.
J Pathol Transl Med, 2020 Nov 07; 55(1). PMID: 33153242    Free PMC article.
Review.
ASCO 2020: highlights in breast cancer.
Rupert Bartsch.
Memo, 2021 Feb 02;. PMID: 33520003    Free PMC article.
Review.
In modern times, how important are breast cancer stage, grade and receptor subtype for survival: a population-based cohort study.
Anna L V Johansson, Cassia B Trewin, +3 authors, Giske Ursin.
Breast Cancer Res, 2021 Feb 03; 23(1). PMID: 33526044    Free PMC article.
Improved detection of sentinel lymph node metastases allows reliable intraoperative identification of patients with extended axillary lymph node involvement in early breast cancer.
Cristina L Cotarelo, Annemarie Zschöck-Manus, +4 authors, Sonja Thaler.
Clin Exp Metastasis, 2020 Nov 30; 38(1). PMID: 33249518    Free PMC article.
Blockage of AMPK-ULK1 pathway mediated autophagy promotes cell apoptosis to increase doxorubicin sensitivity in breast cancer (BC) cells: an in vitro study.
Libo Yu, Qingtao Shi, +3 authors, Wenzhou Sun.
BMC Cancer, 2021 Feb 27; 21(1). PMID: 33632157    Free PMC article.
Relationships between pathological factors and long-term outcomes in patients enrolled in two prospective randomized controlled trials comparing the efficacy of oral tegafur-uracil with CMF (N·SAS-BC 01 trial and CUBC trial).
Shinji Ohno, Shigehira Saji, +11 authors, Yasuo Ohashi.
Breast Cancer Res Treat, 2020 Dec 02; 186(1). PMID: 33259001    Free PMC article.
Adjuvant bisphosphonate use in patients with early stage breast cancer: Patient perspectives on treatment acceptability and potential de-escalation.
Sharon McGee, Mashari AlZahrani, +11 authors, Mark Clemons.
J Bone Oncol, 2021 Mar 09; 27. PMID: 33680749    Free PMC article.
Predictive risk factors for sentinel lymph node metastasis using preoperative contrast-enhanced ultrasound in early-stage breast cancer patients.
Jianghua Qiao, Juntao Li, +3 authors, Zhenduo Lu.
Gland Surg, 2021 Mar 13; 10(2). PMID: 33708558    Free PMC article.
Sentinel Lymph Node Biopsy in T3 and T4b Breast Cancer Patients: Analysis in a Tertiary Cancer Hospital and Systematic Literature Review.
Idam de Oliveira-Junior, Eliana Aguiar Petri Nahas, +2 authors, René Aloisio da Costa Vieira.
Breast Care (Basel), 2021 Mar 16; 16(1). PMID: 33716629    Free PMC article.
Adequacy of early-stage breast cancer systemic adjuvant treatment to Saint Gallen-2013 statement: the MCC-Spain study.
Inés Gómez-Acebo, Trinidad Dierssen-Sotos, +20 authors, Javier Llorca.
Sci Rep, 2021 Mar 10; 11(1). PMID: 33686151    Free PMC article.
Adjuvant bisphosphonate use in patients with early stage breast cancer: a physician survey.
Sharon McGee, Mashari Alzahrani, +7 authors, Mark Clemons.
Breast Cancer Res Treat, 2021 Mar 24;. PMID: 33755864    Free PMC article.
Adjuvant endocrine therapy in HER2-positive breast cancer patients: systematic review and meta-analysis.
S Peleg Hasson, M R Brezis, +3 authors, A Sonnenblick.
ESMO Open, 2021 Mar 19; 6(2). PMID: 33735801    Free PMC article.
Review.
Mutant Allele Frequency-Based Intra-Tumoral Genetic Heterogeneity Related to the Tumor Shrinkage Mode After Neoadjuvant Chemotherapy in Breast Cancer Patients.
Chun-Hui Zheng, Zhao-Yun Liu, +9 authors, Yong-Sheng Wang.
Front Med (Lausanne), 2021 Apr 20; 8. PMID: 33869255    Free PMC article.
Impact of COVID-19 On Breast Cancer Management: A Radiological Prespective from A Tertiary Centre.
Anjum Syed, Gangotri Kumari, +8 authors, Bina Ravi.
Eur J Breast Health, 2021 Apr 20; 17(2). PMID: 33870119    Free PMC article.
Axillary management in early breast cancer with onset surgical management and positive sentinel lymph node.
Lia Pamela Rebaza Vasquez, Jaime Ponce de la Torre, +2 authors, Henry Gomez Moreno.
Ecancermedicalscience, 2021 Apr 24; 15. PMID: 33889202    Free PMC article.
Review.
Androgen receptor expression is useful to predict the therapeutic effect in HER2-positive breast carcinoma.
Momoko Akashi, Rin Yamaguchi, +9 authors, Hirohisa Yano.
Breast Cancer Res Treat, 2020 Aug 10; 184(2). PMID: 32770457
Efficacy and safety analysis of paclitaxel, docetaxel and liposomal paclitaxel after neoadjuvant therapy in breast cancer.
Zhao Bi, Peng Chen, +4 authors, Yong-Sheng Wang.
Breast Cancer Res Treat, 2020 Aug 11; 184(2). PMID: 32776291