. 2017 Aug; 377(9):849-861.
doi: 10.1056/NEJMra1703413.

Precision Diagnosis and Treatment for Advanced Non-Small-Cell Lung Cancer

Martin Reck 1 Klaus F Rabe 1 
  • PMID: 28854088
  •     154 citations

No abstract available

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Lgr6: From Stemness to Cancer Progression.
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Integrative gene expression profiling reveals that dysregulated triple microRNAs confer paclitaxel resistance in non-small cell lung cancer via co-targeting MAPT.
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MicroRNA-608 Promotes Apoptosis in Non-Small Cell Lung Cancer Cells Treated With Doxorubicin Through the Inhibition of TFAP4.
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The association of PD-L1 expression with the efficacy of anti-PD-1/PD-L1 immunotherapy and survival of non-small cell lung cancer patients: a meta-analysis of randomized controlled trials.
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LncRNA LINC01116 Contributes to Cisplatin Resistance in Lung Adenocarcinoma.
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Mass Spectrometry Imaging for Reliable and Fast Classification of Non-Small Cell Lung Cancer Subtypes.
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Expression of POU2F3 Transcription Factor Control Inflammation, Immunological Recruitment and Metastasis of Pancreatic Cancer in Mice.
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Pearls and pitfalls in lung cancer staging.
Lucian Beer, Ankush Jajodia, Helmut Prosch.
BJR Open, 2020 Nov 13; 2(1). PMID: 33178978    Free PMC article.
Case Report: A Chronological Combination Treatment of Icotinib, Osimertinib, and Crizotinib on Lung Adenocarcinoma Guided by Serial Genetic Tests of Circulating Tumor DNA and Sediment Cell Genomic DNA From Pleural Effusion.
Zhihua Miao, Tianhao Mu, +12 authors, Xinhua Shu.
Front Oncol, 2020 Nov 17; 10. PMID: 33194628    Free PMC article.
A prognostic model for elderly patients with squamous non-small cell lung cancer: a population-based study.
Siying Chen, Chunxia Gao, +3 authors, Yalin Dong.
J Transl Med, 2020 Nov 18; 18(1). PMID: 33198777    Free PMC article.
Application of "omics" sciences to the prediction of bone metastases from breast cancer: State of the art.
Marica Gentile, Antonella Centonza, +4 authors, Stella D'Oronzo.
J Bone Oncol, 2020 Nov 27; 26. PMID: 33240786    Free PMC article.
Immunotherapy Moves to the Early-Stage Setting in Non-Small Cell Lung Cancer: Emerging Evidence and the Role of Biomarkers.
Xabier Mielgo-Rubio, Virginia Calvo, +11 authors, Felipe Couñago.
Cancers (Basel), 2020 Nov 26; 12(11). PMID: 33233705    Free PMC article.
Polymyxin B hemoperfusion in endotoxemic septic shock patients without extreme endotoxemia: a post hoc analysis of the EUPHRATES trial.
D J Klein, D Foster, +3 authors, M Antonelli.
Intensive Care Med, 2018 Nov 25; 44(12). PMID: 30470853    Free PMC article.
Hypoxia‑induced galectin‑3 enhances RhoA function to activate the motility of tumor cells in non‑small cell lung cancer.
Yoko Kataoka, Yasuhiko Ohshio, +3 authors, Jun Hanaoka.
Oncol Rep, 2018 Dec 12; 41(2). PMID: 30535445    Free PMC article.
Chimeric antigen receptor T cell targeting EGFRvIII for metastatic lung cancer therapy.
Zhao Zhang, Jun Jiang, +7 authors, Zhinan Chen.
Front Med, 2019 Feb 06; 13(1). PMID: 30721445
Autophagy inhibition potentiates the anti-angiogenic property of multikinase inhibitor anlotinib through JAK2/STAT3/VEGFA signaling in non-small cell lung cancer cells.
Lijun Liang, Kaiyuan Hui, +12 authors, Xiaodong Jiang.
J Exp Clin Cancer Res, 2019 Feb 14; 38(1). PMID: 30755242    Free PMC article.
Reliability of PD-L1 assays using small tissue samples compared with surgical specimens.
Insu Kim, Ahrong Kim, +10 authors, Jung Seop Eom.
Medicine (Baltimore), 2019 Apr 05; 98(14). PMID: 30946323    Free PMC article.
Notch pathway in small-cell lung cancer: from preclinical evidence to therapeutic challenges.
Alessandro Leonetti, Francesco Facchinetti, +4 authors, Marcello Tiseo.
Cell Oncol (Dordr), 2019 Apr 11; 42(3). PMID: 30968324
Establishment and validation of a novel survival prediction scoring algorithm for patients with non-small-cell lung cancer spinal metastasis.
Shizhao Zang, Qin He, +2 authors, Weibin Zhang.
Int J Clin Oncol, 2019 Apr 28; 24(9). PMID: 31028506
[Advances of Exosomes Extraction and Its Mechanism in Early Diagnosis of Lung Cancer].
Dan Luo, Chunlei Li, Lun Wu, Qinhua Chen.
Zhongguo Fei Ai Za Zhi, 2020 Aug 06; 23(11). PMID: 32752584    Free PMC article.
LncRNA SNHG20 promoted proliferation, invasion and inhibited cell apoptosis of lung adenocarcinoma via sponging miR-342 and upregulating DDX49.
Xiuli Wang, Guomin Gu, +3 authors, Chunling Liu.
Thorac Cancer, 2020 Oct 23; 11(12). PMID: 33089952    Free PMC article.
LncRNA MALAT1 accelerates non-small cell lung cancer progression via regulating miR-185-5p/MDM4 axis.
Dan Wang, Suhong Zhang, Min Zhao, Fengling Chen.
Cancer Med, 2020 Nov 05; 9(23). PMID: 33146951    Free PMC article.
LINC00857 Interacting with YBX1 to Regulate Apoptosis and Autophagy via MET and Phosphor-AMPKa Signaling.
Wenmei Su, Lihui Wang, +8 authors, Guoan Chen.
Mol Ther Nucleic Acids, 2020 Dec 15; 22. PMID: 33312753    Free PMC article.
Establishment of multiplex allele-specific blocker PCR for enrichment and detection of 4 common EGFR mutations in non-small cell lung cancer.
Hongyuan Chen, Jie Zhang, +2 authors, Daru Lu.
Ann Transl Med, 2020 Dec 15; 8(22). PMID: 33313254    Free PMC article.
Upregulated Collagen COL10A1 Remodels the Extracellular Matrix and Promotes Malignant Progression in Lung Adenocarcinoma.
Yingkuan Liang, Wenjie Xia, +7 authors, Feng Jiang.
Front Oncol, 2020 Dec 17; 10. PMID: 33324550    Free PMC article.
Identifying Cross-Scale Associations between Radiomic and Pathomic Signatures of Non-Small Cell Lung Cancer Subtypes: Preliminary Results.
Charlems Alvarez-Jimenez, Alvaro A Sandino, +3 authors, Eduardo Romero.
Cancers (Basel), 2020 Dec 11; 12(12). PMID: 33297357    Free PMC article.
Lung Adenocarcinoma Mouse Models Based on Orthotopic Transplantation of Syngeneic Tumor-Initiating Cells Expressing EpCAM, SCA-1, and Ly6d.
Takashi Semba, Ryo Sato, +6 authors, Yoshimi Arima.
Cancers (Basel), 2020 Dec 23; 12(12). PMID: 33348616    Free PMC article.
NUCKS1 Promotes Proliferation, Invasion and Migration of Non-Small Cell Lung Cancer by Upregulating CDK1 Expression.
Shufen Zhao, Baiyao Wang, +3 authors, Yawei Yuan.
Cancer Manag Res, 2021 Jan 01; 12. PMID: 33380837    Free PMC article.
Evaluation of cytokines in the tumor microenvironment of lung cancer using bronchoalveolar lavage fluid analysis.
Pascal Bezel, Alan Valaperti, +7 authors, Daniel P Franzen.
Cancer Immunol Immunother, 2021 Jan 05; 70(7). PMID: 33394095
Utilization of circulating cell-free DNA profiling to guide first-line chemotherapy in advanced lung squamous cell carcinoma.
Tao Jiang, Liyan Jiang, +41 authors, Caicun Zhou.
Theranostics, 2021 Jan 05; 11(1). PMID: 33391473    Free PMC article.
Lnc-GAN1 expression is associated with good survival and suppresses tumor progression by sponging mir-26a-5p to activate PTEN signaling in non-small cell lung cancer.
Rui-Qi Wang, Xiao-Ran Long, +8 authors, Hui-Yun Wang.
J Exp Clin Cancer Res, 2021 Jan 08; 40(1). PMID: 33407724    Free PMC article.
IDH1 and IDH2 mutations in lung adenocarcinomas: Evidences of subclonal evolution.
Erika F Rodriguez, Federico De Marchi, +6 authors, Ming-Tseh Li.
Cancer Med, 2020 Apr 26; 9(12). PMID: 32333643    Free PMC article.
Construction of Radiation Surviving/Resistant Lung Cancer Cell Lines with Equidifferent Gradient Dose Irradiation.
Lijuan Wang, Shangbiao Li, Xiaoxia Zhu.
Dose Response, 2021 Jan 12; 18(4). PMID: 33424518    Free PMC article.
Lobaplatin Enhances Radioactive 125I Seed-Induced Apoptosis and Anti-Proliferative Effect in Non-Small Cell Lung Cancer by Suppressing the AKT/mTOR Pathway.
Jia-Hui Rong, Dong Li, Yu-Liang Li.
Onco Targets Ther, 2021 Jan 21; 14. PMID: 33469307    Free PMC article.
A narrative review of evolving roles of radiotherapy in advanced non-small cell lung cancer: from palliative care to active player.
Yue Zhou, Fan Yu, +9 authors, Jianjiao Ni.
Transl Lung Cancer Res, 2021 Jan 26; 9(6). PMID: 33489808    Free PMC article.
2020 Clinical Practice Guideline for Percutaneous Transthoracic Needle Biopsy of Pulmonary Lesions: A Consensus Statement and Recommendations of the Korean Society of Thoracic Radiology.
Soon Ho Yoon, Sang Min Lee, +15 authors, Chang Min Park.
Korean J Radiol, 2020 Nov 26; 22(2). PMID: 33236542    Free PMC article.
Systematic construction and validation of an epithelial-mesenchymal transition risk model to predict prognosis of lung adenocarcinoma.
Yunliang Tang, Yanxia Jiang, +2 authors, Zhenguo Zeng.
Aging (Albany NY), 2020 Dec 20; 13(1). PMID: 33340396    Free PMC article.
Application of a treatment planning system-assisted large-aperture computed tomography simulator to percutaneous biopsy: initial experience of a radiation therapist.
Xiaoyi Lin, Liqin Ma, +5 authors, Xiangquan Kong.
J Int Med Res, 2021 Jan 22; 49(1). PMID: 33472476    Free PMC article.
Long non‑coding RNA PITPNA‑AS1 silencing suppresses proliferation, metastasis and epithelial‑mesenchymal transition in non‑small cell lung cancer cells by targeting microRNA‑32‑5p.
Gang Chen, Zhifeng Zheng, +6 authors, Huixin Li.
Mol Med Rep, 2021 Jan 27; 23(3). PMID: 33495838    Free PMC article.
Long-term progression-free survival in a patient with advanced non-small-cell lung cancer treated with low-dose gefitinib and traditional herbal medicine: A case report.
Beom-Joon Lee, Kwan-Il Kim, +2 authors, Jun-Hwan Lee.
Medicine (Baltimore), 2021 Feb 18; 100(5). PMID: 33592873    Free PMC article.
Phosphorylation of SMAD3 in immune cells predicts survival of patients with early stage non-small cell lung cancer.
Sebastian Marwitz, Carmen Ballesteros-Merino, +6 authors, Bernard A Fox.
J Immunother Cancer, 2021 Feb 17; 9(2). PMID: 33589523    Free PMC article.
Survival Outcomes with Photodynamic Therapy, Chemotherapy and Radiation in Patients with Stage III or Stage IV Non-Small Cell Lung Cancer.
Sumedha Chhatre, Anil Vachani, Ron R Allison, Ravishankar Jayadevappa.
Cancers (Basel), 2021 Mar 07; 13(4). PMID: 33671863    Free PMC article.
Identification of a ceRNA Network in Lung Adenocarcinoma Based on Integration Analysis of Tumor-Associated Macrophage Signature Genes.
Lei Zhang, Kai Zhang, +7 authors, Jiaxiang Wang.
Front Cell Dev Biol, 2021 Mar 20; 9. PMID: 33738286    Free PMC article.
Treatment- and immune-related adverse events of immune checkpoint inhibitors in advanced lung cancer.
Jun Shao, Chengdi Wang, +3 authors, Weimin Li.
Biosci Rep, 2020 Apr 22; 40(5). PMID: 32315071    Free PMC article.
Systematic Review.
Enhanced expression of FGF19 predicts poor prognosis in patients with non-small cell lung cancer.
Jia Chen, Jingjing Shao, +5 authors, Yang Ling.
J Thorac Dis, 2021 Apr 13; 13(3). PMID: 33841967    Free PMC article.
A circular network of coregulated sphingolipids dictates lung cancer growth and progression.
Qiong Meng, Xueting Hu, +10 authors, Ping-Pui Wong.
EBioMedicine, 2021 Apr 05; 66. PMID: 33813137    Free PMC article.
Identification of transcriptional subtypes in lung adenocarcinoma and squamous cell carcinoma through integrative analysis of microarray and RNA sequencing data.
François Fauteux, Anuradha Surendra, +2 authors, Jennifer J Hill.
Sci Rep, 2021 Apr 24; 11(1). PMID: 33888829    Free PMC article.
HER2 transmembrane domain mutation: comprehensive characteristics and real-world evidence of treatment response in Chinese lung adenocarcinoma.
Ziqi Jia, Jiahua Xing, +25 authors, Shanqing Li.
Transl Lung Cancer Res, 2021 Apr 24; 10(3). PMID: 33889517    Free PMC article.
The optimal immune checkpoint inhibitors combined with chemotherapy for advanced non-small-cell lung cancer: a systematic review and meta-analysis.
Y Yang, H Luo, X L Zheng, H Ge.
Clin Transl Oncol, 2020 Nov 20; 23(6). PMID: 33211281
Efficacy and acquired resistance for EGFR-TKI plus thoracic SBRT in patients with advanced EGFR-mutant non-small-cell lung cancer: a propensity-matched retrospective study.
Xia Wang, Zhimin Zeng, +4 authors, Anwen Liu.
BMC Cancer, 2021 May 02; 21(1). PMID: 33931014    Free PMC article.
TP53-Activated lncRNA GHRLOS Regulates Cell Proliferation, Invasion, and Apoptosis of Non-Small Cell Lung Cancer by Modulating the miR-346/APC Axis.
Ke Ren, Jinghui Sun, +7 authors, Wei Zhao.
Front Oncol, 2021 May 11; 11. PMID: 33968785    Free PMC article.
EBUS-TBNA Cytological Samples for Comprehensive Molecular Testing in Non-Small Cell Lung Cancer.
Roberto Martin-Deleon, Cristina Teixido, +14 authors, Noemi Reguart.
Cancers (Basel), 2021 May 01; 13(9). PMID: 33923116    Free PMC article.
Comprehensive analysis of tumor microenvironment and identification of an immune signature to predict the prognosis and immunotherapeutic response in lung squamous cell carcinoma.
Jinlong Wu, Chengfeng Xu, +4 authors, Mingsong Wang.
Ann Transl Med, 2021 May 15; 9(7). PMID: 33987267    Free PMC article.
Long non-coding RNA SLC25A25-AS1 exhibits oncogenic roles in non-small cell lung cancer by regulating the microRNA-195-5p/ITGA2 axis.
Jinqin Chen, Chengpeng Gao, Wei Zhu.
Oncol Lett, 2021 Jun 01; 22(1). PMID: 34055094    Free PMC article.
Testing EGFR with Idylla on Cytological Specimens of Lung Cancer: A Review.
Alessandro Caputo, Angela D'Ardia, +4 authors, Antonio D'Antonio.
Int J Mol Sci, 2021 Jun 03; 22(9). PMID: 34063720    Free PMC article.
Immunotherapy in non-small cell lung cancer: Update and new insights.
Xabier Mielgo-Rubio, Eider Azkona Uribelarrea, Laura Quintanta Cortés, María Sereno Moyano.
J Clin Transl Res, 2021 Jun 10; 7(1). PMID: 34104805    Free PMC article.
Advances in multimodal treatment for stage IIIA-N2 non-small cell lung cancer.
Sara Montemuiño Muñiz, Soraya Marcos Sánchez, +11 authors, Felipe Couñago.
J Clin Transl Res, 2021 Jun 10; 7(2). PMID: 34104821    Free PMC article.