Review
. 2017 Aug; 377(9):849-861.
doi: 10.1056/NEJMra1703413.

Precision Diagnosis and Treatment for Advanced Non-Small-Cell Lung Cancer

Martin Reck 1 Klaus F Rabe 1 
Affiliations
  • PMID: 28854088
  •     154 citations

No abstract available

Recent development in clinical applications of PD-1 and PD-L1 antibodies for cancer immunotherapy.
Bingshan Liu, Yongping Song, Delong Liu.
J Hematol Oncol, 2017 Dec 03; 10(1). PMID: 29195503    Free PMC article.
Highly Cited. Review.
The biology and management of non-small cell lung cancer.
Roy S Herbst, Daniel Morgensztern, Chris Boshoff.
Nature, 2018 Jan 25; 553(7689). PMID: 29364287
Highly Cited. Review.
Wide Expression and Significance of Alternative Immune Checkpoint Molecules, B7x and HHLA2, in PD-L1-Negative Human Lung Cancers.
Haiying Cheng, Alain Borczuk, +6 authors, Xingxing Zang.
Clin Cancer Res, 2018 Jan 28; 24(8). PMID: 29374053    Free PMC article.
Extracellular vesicle-derived DNA for performing EGFR genotyping of NSCLC patients.
Jae Young Hur, Hee Joung Kim, +5 authors, Kye Young Lee.
Mol Cancer, 2018 Jan 29; 17(1). PMID: 29374476    Free PMC article.
Review.
Peptide Nucleic Acid Clamping and Direct Sequencing in the Detection of Oncogenic Alterations in Lung Cancer: Systematic Review and Meta-Analysis.
Jae Uk Song, Jonghoo Lee.
Yonsei Med J, 2018 Feb 13; 59(2). PMID: 29436188    Free PMC article.
Systematic Review.
The impact of PD-L1 on survival and value of the immune check point inhibitors in non-small-cell lung cancer; proposal, policies and perspective.
Helmy M Guirgis.
J Immunother Cancer, 2018 Feb 22; 6(1). PMID: 29463302    Free PMC article.
GRK5 functions as an oncogenic factor in non-small-cell lung cancer.
Li-Ping Jiang, Song-Qing Fan, +9 authors, Yong-Bin Chen.
Cell Death Dis, 2018 Feb 22; 9(3). PMID: 29463786    Free PMC article.
PD-L1 expression testing in non-small cell lung cancer.
Cristina Teixidó, Noelia Vilariño, Roxana Reyes, Noemí Reguart.
Ther Adv Med Oncol, 2018 Apr 18; 10. PMID: 29662547    Free PMC article.
Highly Cited. Review.
[Role of visceral surgery in oligometastases of non-gastrointestinal tumors].
R Wahba, D Stippel, C Bruns.
Chirurg, 2018 May 17; 89(7). PMID: 29767820
Review.
No room for statins in the quest for survival benefits in small cell lung cancer.
Francesco Facchinetti, Marcello Tiseo.
Transl Lung Cancer Res, 2018 May 22; 7(Suppl 2). PMID: 29780705    Free PMC article.
Rapid expansion in the WAVE bioreactor of clinical scale cells for tumor immunotherapy.
Yiming Meng, Jing Sun, +6 authors, Haozhe Piao.
Hum Vaccin Immunother, 2018 May 31; 14(10). PMID: 29847223    Free PMC article.
Diagnosing Lung Cancer: The Complexities of Obtaining a Tissue Diagnosis in the Era of Minimally Invasive and Personalised Medicine.
Anna E B McLean, David J Barnes, Lauren K Troy.
J Clin Med, 2018 Jul 04; 7(7). PMID: 29966246    Free PMC article.
Review.
A network meta-analysis of nonsmall-cell lung cancer patients with an activating EGFR mutation: Should osimertinib be the first-line treatment?
Jia-Zhou Lin, Song-Kun Ma, +2 authors, Xu-Yuan Li.
Medicine (Baltimore), 2018 Jul 26; 97(30). PMID: 30045282    Free PMC article.
Downregulation of GSDMD attenuates tumor proliferation via the intrinsic mitochondrial apoptotic pathway and inhibition of EGFR/Akt signaling and predicts a good prognosis in non‑small cell lung cancer.
Jianwei Gao, Xiangyu Qiu, +4 authors, Yong Song.
Oncol Rep, 2018 Aug 15; 40(4). PMID: 30106450    Free PMC article.
Adaptive metabolic pattern biomarker for disease monitoring and staging of lung cancer with liquid biopsy.
Manuel Garcia-Algar, Ana Fernandez-Carrascal, +6 authors, Ramon A Alvarez-Puebla.
NPJ Precis Oncol, 2018 Aug 16; 2. PMID: 30109276    Free PMC article.
Anti-tumor effect of CDK inhibitors on CDKN2A-defective squamous cell lung cancer cells.
Eun-Hui Jeong, Tae-Gul Lee, +4 authors, Cheol Hyeon Kim.
Cell Oncol (Dordr), 2018 Sep 05; 41(6). PMID: 30178167
Biomarkers in the diagnosis of pleural diseases: a 2018 update.
José M Porcel.
Ther Adv Respir Dis, 2018 Oct 26; 12. PMID: 30354850    Free PMC article.
Review.
Resistance to anti-PD-1-based immunotherapy in basal cell carcinoma: a case report and review of the literature.
Francesco Sabbatino, Antonio Marra, +5 authors, Stefano Pepe.
J Immunother Cancer, 2018 Nov 22; 6(1). PMID: 30458852    Free PMC article.
Review.
Short- and long-term outcomes in elderly patients with locally advanced non-small-cell lung cancer treated using video-assisted thoracic surgery lobectomy.
Like Zhang.
Ther Clin Risk Manag, 2018 Dec 05; 14. PMID: 30510426    Free PMC article.
Clinical Validation of Discordant Trunk Driver Mutations in Paired Primary and Metastatic Lung Cancer Specimens.
Li-Hui Tseng, Federico De Marchi, +7 authors, Ming-Tseh Lin.
Am J Clin Pathol, 2019 Jul 03; 152(5). PMID: 31264684    Free PMC article.
Subtyping Lung Cancer Using DNA Methylation in Liquid Biopsies.
Sandra P Nunes, Francisca Diniz, +10 authors, Carmen Jerónimo.
J Clin Med, 2019 Sep 25; 8(9). PMID: 31546933    Free PMC article.
First-line treatments in EGFR-mutated advanced non-small cell lung cancer: A network meta-analysis.
Hongwei Zhang, Jun Chen, +2 authors, Guang Li.
PLoS One, 2019 Oct 04; 14(10). PMID: 31581247    Free PMC article.
[Local consolidative therapy vs. maintenance therapy or observation for patients with oligometastatic non-small-cell lung cancer: long-term results of a multi-institutional, phase II, randomized study].
Alexander Fabian, Florian Pyschny, David Krug.
Strahlenther Onkol, 2019 Oct 23; 195(12). PMID: 31637448
Identification of a novel synthetic lethal vulnerability in non-small cell lung cancer by co-targeting TMPRSS4 and DDR1.
Maria Villalba, Esther Redin, +17 authors, Alfonso Calvo.
Sci Rep, 2019 Oct 30; 9(1). PMID: 31659178    Free PMC article.
EMT-Mediated Acquired EGFR-TKI Resistance in NSCLC: Mechanisms and Strategies.
Xuan Zhu, Lijie Chen, Ling Liu, Xing Niu.
Front Oncol, 2019 Nov 05; 9. PMID: 31681582    Free PMC article.
Review.
Driving the discussion about the greater propensity for doing better with neoadjuvant chemotherapy for non-small cell lung cancer.
Abigail K Zamora, Anthony W Kim.
J Thorac Dis, 2019 Nov 19; 11(10). PMID: 31737332    Free PMC article.
Comparison of in situ and extraction-based methods for the detection of MET amplifications in solid tumors.
Carina Heydt, Ann-Kathrin Becher, +6 authors, Sabine Merkelbach-Bruse.
Comput Struct Biotechnol J, 2019 Nov 26; 17. PMID: 31762957    Free PMC article.
KRAS and ERBB-family genetic alterations affect response to PD-1 inhibitors in metastatic nonsquamous NSCLC.
Marika Cinausero, Noemi Laprovitera, +13 authors, Andrea Ardizzoni.
Ther Adv Med Oncol, 2019 Dec 05; 11. PMID: 31798692    Free PMC article.
PPARα ligand, AVE8134, and cyclooxygenase inhibitor therapy synergistically suppress lung cancer growth and metastasis.
Lujin Wu, Wei Wang, +3 authors, Daowen Wang.
BMC Cancer, 2019 Dec 04; 19(1). PMID: 31791289    Free PMC article.
C-X-C chemokine receptor 2 correlates with unfavorable prognosis and facilitates malignant cell activities via activating JAK2/STAT3 pathway in non-small cell lung cancer.
Lin Wei, Yugang Liu, +5 authors, Changsheng Zhu.
Cell Cycle, 2019 Nov 17; 18(24). PMID: 31731888    Free PMC article.
Gli promotes tumor progression through regulating epithelial-mesenchymal transition in non-small-cell lung cancer.
Long Jiang, Jia Huang, +3 authors, Lei Wang.
J Cardiothorac Surg, 2020 Jan 15; 15(1). PMID: 31931858    Free PMC article.
A Prediction Model to Help with Oncologic Mediastinal Evaluation for Radiation: HOMER.
Gabriela Martinez-Zayas, Francisco A Almeida, +17 authors, David E Ost.
Am J Respir Crit Care Med, 2019 Oct 02; 201(2). PMID: 31574238    Free PMC article.
Role of Gd2O3-doped carbon-11-choline-lenvatinib nanoparticles contrast agent PET/CT in the diagnosis of patients with lung cancer.
Tong Zhou, Dongfang Hang, +5 authors, Jun Yan.
Oncol Lett, 2020 Feb 01; 19(2). PMID: 32002026    Free PMC article.
Inhibitor of DNA-Binding Protein 4 Suppresses Cancer Metastasis through the Regulation of Epithelial Mesenchymal Transition in Lung Adenocarcinoma.
Chi-Chung Wang, Yuan-Ling Hsu, +3 authors, Szu-Hua Pan.
Cancers (Basel), 2019 Dec 19; 11(12). PMID: 31847356    Free PMC article.
The Multi-Modal Effect of the Anti-fibrotic Drug Pirfenidone on NSCLC.
Sebastian Marwitz, Kati Turkowski, +10 authors, Torsten Goldmann.
Front Oncol, 2020 Feb 11; 9. PMID: 32039023    Free PMC article.
Prediction of Pleural Invasion in Challenging Non-Small-Cell Lung Cancer Patients Using Serum and Imaging Markers.
Kaibin Zhu, Lantao Chen, +4 authors, Shidong Xu.
Dis Markers, 2020 Feb 25; 2020. PMID: 32089756    Free PMC article.
Circulating Tumor Cells as a Biomarker to Assist Molecular Diagnosis for Early Stage Non-Small Cell Lung Cancer.
Yutong He, Jin Shi, +7 authors, Baoen Shan.
Cancer Manag Res, 2020 Feb 28; 12. PMID: 32104066    Free PMC article.
MicroRNA Modification of Coxsackievirus B3 Decreases Its Toxicity, while Retaining Oncolytic Potency against Lung Cancer.
Huitao Liu, Yuan Chao Xue, +7 authors, Honglin Luo.
Mol Ther Oncolytics, 2020 Mar 04; 16. PMID: 32123721    Free PMC article.
Dysregulated Redox Regulation Contributes to Nuclear EGFR Localization and Pathogenicity in Lung Cancer.
Andrew C Little, Milena Hristova, +9 authors, Albert van der Vliet.
Sci Rep, 2019 Mar 21; 9(1). PMID: 30890751    Free PMC article.
Twenty-eight-day mortality in lung cancer patients with metastasis who initiated mechanical ventilation in the emergency department.
Sun Hye Shin, Hyun Lee, Hyung Koo Kang, Joo Hyun Park.
Sci Rep, 2019 Mar 22; 9(1). PMID: 30894559    Free PMC article.
CircRNA CDR1as knockdown inhibits progression of non-small-cell lung cancer by regulating miR-219a-5p/SOX5 axis.
Yaming Li, Jinzhao Zhang, +3 authors, Song Liu.
Thorac Cancer, 2020 Jan 10; 11(3). PMID: 31917898    Free PMC article.
Cost-effectiveness analysis of pembrolizumab plus chemotherapy with PD-L1 test for the first-line treatment of NSCLC.
Ning Wan, Tian-Tian Zhang, +7 authors, Jian Li.
Cancer Med, 2020 Jan 17; 9(5). PMID: 31945265    Free PMC article.
Cost-Effectiveness of Osimertinib in Treating Newly Diagnosed, Advanced EGFR-Mutation-Positive Non-Small Cell Lung Cancer.
Bin Wu, Xiaohua Gu, Qiang Zhang, Feng Xie.
Oncologist, 2018 Sep 28; 24(3). PMID: 30257889    Free PMC article.
Comparison of the genomic background of MET-altered carcinomas of the lung: biological differences and analogies.
Roberta Castiglione, Christina Alidousty, +11 authors, Anne Maria Schultheis.
Mod Pathol, 2018 Nov 22; 32(5). PMID: 30459450    Free PMC article.
Scutellarin suppresses proliferation and promotes apoptosis in A549 lung adenocarcinoma cells via AKT/mTOR/4EBP1 and STAT3 pathways.
Pikun Cao, Bin Liu, +5 authors, Yuliang Li.
Thorac Cancer, 2019 Jan 23; 10(3). PMID: 30666790    Free PMC article.
MPC1 deficiency accelerates lung adenocarcinoma progression through the STAT3 pathway.
Hongbo Zou, Qian Chen, +17 authors, Chuan Xu.
Cell Death Dis, 2019 Feb 17; 10(3). PMID: 30770798    Free PMC article.
Mutations in DNA repair genes are associated with increased neoantigen burden and a distinct immunophenotype in lung squamous cell carcinoma.
Young Kwang Chae, Jonathan F Anker, +5 authors, Jeffrey H Chuang.
Sci Rep, 2019 Mar 03; 9(1). PMID: 30824826    Free PMC article.
Molecular Profiling of Inflammatory Bowel Disease: Is It Ready for Use in Clinical Decision-Making?
Ho-Su Lee, Isabelle Cleynen.
Cells, 2019 Jun 07; 8(6). PMID: 31167397    Free PMC article.
Review.
Genomic landscape and its correlations with tumor mutational burden, PD-L1 expression, and immune cells infiltration in Chinese lung squamous cell carcinoma.
Tao Jiang, Jinpeng Shi, +13 authors, Caicun Zhou.
J Hematol Oncol, 2019 Jul 14; 12(1). PMID: 31299995    Free PMC article.
Covalent chemistry on nanostructured substrates enables noninvasive quantification of gene rearrangements in circulating tumor cells.
Jiantong Dong, Yu Jen Jan, +24 authors, Yazhen Zhu.
Sci Adv, 2019 Aug 09; 5(7). PMID: 31392269    Free PMC article.
FAM83A signaling induces epithelial-mesenchymal transition by the PI3K/AKT/Snail pathway in NSCLC.
Fengrui Zhou, Jianxiong Geng, +6 authors, Yan Yu.
Aging (Albany NY), 2019 Aug 25; 11(16). PMID: 31444970    Free PMC article.
Lung tumorspheres reveal cancer stem cell-like properties and a score with prognostic impact in resected non-small-cell lung cancer.
Alejandro Herreros-Pomares, Juan Diego de-Maya-Girones, +16 authors, Carlos Camps.
Cell Death Dis, 2019 Sep 12; 10(9). PMID: 31506430    Free PMC article.
The MyoD family inhibitor domain-containing protein enhances the chemoresistance of cancer stem cells in the epithelial state by increasing β-catenin activity.
Chao-Ju Chen, Chih-Jen Yang, +2 authors, Yu-Peng Liu.
Oncogene, 2020 Jan 09; 39(11). PMID: 31911618
Xiao-ai-ping injection adjunct with platinum-based chemotherapy for advanced non-small-cell lung cancer: a systematic review and meta-analysis.
Fanchao Feng, Jingyi Huang, +5 authors, Xianmei Zhou.
BMC Complement Med Ther, 2020 Feb 06; 20(1). PMID: 32020869    Free PMC article.
Systematic Review.
Upregulation of deubiquitinase PSMD14 in lung adenocarcinoma (LUAD) and its prognostic significance.
Ling Zhang, Hui Xu, +5 authors, Dawei Li.
J Cancer, 2020 Apr 01; 11(10). PMID: 32226511    Free PMC article.
Real-World Evidence: Multicenter Efficacy and Toxicity Analysis of Nintedanib With Docetaxel as Second-Line Treatment in Mexican Patients With Advanced Lung Adenocarcinoma.
Jeronimo Rafael Rodríguez-Cid, Saul Campos-Gomez, +25 authors, Jorge Arturo Alatorre-Alexander.
JCO Glob Oncol, 2020 Mar 21; 6. PMID: 32196388    Free PMC article.
[Correlation between the Expression of PD-L1 in Pleural Effusion of Lung Adenocarcinoma and the Clinicopathological Features and Molecular Changes].
Haiyue Ma, Jia Jia, +6 authors, Zhihui Zhang.
Zhongguo Fei Ai Za Zhi, 2020 Mar 27; 23(3). PMID: 32209183    Free PMC article.
Targeting the Interplay between Epithelial-to-Mesenchymal-Transition and the Immune System for Effective Immunotherapy.
Rama Soundararajan, Jared J Fradette, +18 authors, Sendurai A Mani.
Cancers (Basel), 2019 May 30; 11(5). PMID: 31137625    Free PMC article.
Review.
A High-Performing Plasma Metabolite Panel for Early-Stage Lung Cancer Detection.
Lun Zhang, Jiamin Zheng, +11 authors, David S Wishart.
Cancers (Basel), 2020 Mar 12; 12(3). PMID: 32156060    Free PMC article.
Identification of somatic copy number variations in plasma cell free DNA correlating with intrinsic resistances to EGFR targeted therapy in T790M negative non-small cell lung cancer.
Lucheng Zhu, Jiafeng Liang, +4 authors, Shirong Zhang.
J Thorac Dis, 2020 Apr 11; 12(3). PMID: 32274156    Free PMC article.
The Atypical Receptor CCRL2 Is Essential for Lung Cancer Immune Surveillance.
Annalisa Del Prete, Francesca Sozio, +11 authors, Silvano Sozzani.
Cancer Immunol Res, 2019 Sep 06; 7(11). PMID: 31484658    Free PMC article.
Rationale for Lung Adenocarcinoma Prevention and Drug Development Based on Molecular Biology During Carcinogenesis.
Hongming Zhang, Liting Guo, Jibei Chen.
Onco Targets Ther, 2020 Apr 29; 13. PMID: 32341654    Free PMC article.
Review.
Liquid biopsy in oncology: a consensus statement of the Spanish Society of Pathology and the Spanish Society of Medical Oncology.
J Remon, R García-Campelo, +7 authors, R Álvarez-Alegret.
Clin Transl Oncol, 2019 Sep 29; 22(6). PMID: 31559582    Free PMC article.
miR-140-3p inhibits progression of non-small cell lung cancer by targeting Janus kinase 1.
Chuan Hu, Yong Zou, Luan-Lian Jing.
J Biosci, 2020 Apr 30; 45. PMID: 32345774
Prognostic value of quantitative measurement of EGFR mutation using peptide nucleic acid clamping in advanced EGFR mutant non-small cell lung cancer patients.
Insu Kim, Jung Seop Eom, +6 authors, Mi-Hyun Kim.
Thorac Cancer, 2019 May 31; 10(7). PMID: 31148357    Free PMC article.
Annual report to the nation on the status of cancer, part II: Progress toward Healthy People 2020 objectives for 4 common cancers.
S Jane Henley, Cheryll C Thomas, +12 authors, Lisa C Richardson.
Cancer, 2020 Mar 13; 126(10). PMID: 32162329    Free PMC article.
Gallic Acid Impedes Non-Small Cell Lung Cancer Progression via Suppression of EGFR-Dependent CARM1-PELP1 Complex.
Dong Wang, Burenbatu Bao.
Drug Des Devel Ther, 2020 May 20; 14. PMID: 32425504    Free PMC article.
Annual report to the nation on the status of cancer, part I: National cancer statistics.
S Jane Henley, Elizabeth M Ward, +14 authors, Betsy A Kohler.
Cancer, 2020 Mar 13; 126(10). PMID: 32162336    Free PMC article.
G9a regulates tumorigenicity and stemness through genome-wide DNA methylation reprogramming in non-small cell lung cancer.
Rajendra P Pangeni, Lu Yang, +7 authors, Dan J Raz.
Clin Epigenetics, 2020 Jun 20; 12(1). PMID: 32552834    Free PMC article.
Proposals for managing patients with thoracic malignancies during COVID-19 pandemic.
N Girard, L Greillier, +14 authors, French-Language Society of Pulmonology SPLF French-language Oncology Group.
Respir Med Res, 2020 Jun 22; 78. PMID: 32563968    Free PMC article.
Impact of Pre-Analytical Conditions on the Antigenicity of Lung Markers: ALK and MET.
Rachel Miller, Trish Thorne-Nuzzo, +3 authors, June Clements.
Appl Immunohistochem Mol Morphol, 2019 Feb 07; 28(5). PMID: 30724750    Free PMC article.
Deep Learning for the Classification of Small-Cell and Non-Small-Cell Lung Cancer.
Mark Kriegsmann, Christian Haag, +18 authors, Katharina Kriegsmann.
Cancers (Basel), 2020 Jun 21; 12(6). PMID: 32560475    Free PMC article.
Machine learning of serum metabolic patterns encodes early-stage lung adenocarcinoma.
Lin Huang, Lin Wang, +12 authors, Kun Qian.
Nat Commun, 2020 Jul 18; 11(1). PMID: 32678093    Free PMC article.
Anlotinib as a molecular targeted therapy for tumors.
Yi Gao, Pengfei Liu, Ruihua Shi.
Oncol Lett, 2020 Jul 30; 20(2). PMID: 32724339    Free PMC article.
Review.
Value of combining PET/CT and clinicopathological features in predicting EGFR mutation in Lung Adenocarcinoma with Bone Metastasis.
Guangyu Yao, Yiyi Zhou, +5 authors, Hui Zhao.
J Cancer, 2020 Aug 04; 11(18). PMID: 32742498    Free PMC article.
Medullary Pancreatic Carcinoma Due to Somatic POLE Mutation: A Distinctive Pancreatic Carcinoma With Marked Long-Term Survival.
Valentyna Kryklyva, Esther Ter Linden, +10 authors, Lodewijk A A Brosens.
Pancreas, 2020 Jul 14; 49(7). PMID: 32658072    Free PMC article.
Time trend of mediastinal lymph node dissection in stage IA non-small cell lung cancer patient who undergo lobectomy: a retrospective study of surveillance, epidemiology, and end results (SEER) database.
Liang Pan, Ran Mo, +3 authors, Jian Hu.
J Cardiothorac Surg, 2020 Aug 03; 15(1). PMID: 32738925    Free PMC article.
Exosomal lncRNA PCAT-1 promotes Kras-associated chemoresistance via immunosuppressive miR-182/miR-217 signaling and p27/CDK6 regulation.
Kalliopi Domvri, Savvas Petanidis, +6 authors, Theodora Katopodi.
Oncotarget, 2020 Aug 06; 11(29). PMID: 32754302    Free PMC article.
New additional scoring formula on the Pathological Features in Stage I Lung Adenocarcinoma Patients: Impact on Survival.
Shilei Zhao, Fengzhou Li, +5 authors, Hidetaka Uramoto.
Int J Med Sci, 2020 Aug 14; 17(13). PMID: 32788866    Free PMC article.
Development of a nomogram for preoperative prediction of lymph node metastasis in non-small cell lung cancer: a SEER-based study.
Chufan Zhang, Qian Song, Lanlin Zhang, Xianghua Wu.
J Thorac Dis, 2020 Aug 18; 12(7). PMID: 32802444    Free PMC article.
Identification of a 4-lncRNA signature predicting prognosis of patients with non-small cell lung cancer: a multicenter study in China.
Rui-Qi Wang, Xiao-Ran Long, +11 authors, Hui-Yun Wang.
J Transl Med, 2020 Aug 21; 18(1). PMID: 32819367    Free PMC article.
Positive tumour CD47 expression is an independent prognostic factor for recurrence in resected non-small cell lung cancer.
Yan Xu, Ji Li, +5 authors, Mengzhao Wang.
ESMO Open, 2020 Aug 25; 5(4). PMID: 32830120    Free PMC article.
Quantitative analysis of endobronchial ultrasound elastography in computed tomography-negative mediastinal and hilar lymph nodes.
Keigo Uchimura, Kei Yamasaki, +6 authors, Kazuhiro Yatera.
Thorac Cancer, 2020 Jul 22; 11(9). PMID: 32691537    Free PMC article.
lnc-REG3G-3-1/miR-215-3p Promotes Brain Metastasis of Lung Adenocarcinoma by Regulating Leptin and SLC2A5.
Chunyang Jiang, Hui Zhao, +3 authors, Xiaoli Hu.
Front Oncol, 2020 Sep 10; 10. PMID: 32903414    Free PMC article.
Real-World Utility of an Amplicon-Based Next-Generation Sequencing Liquid Biopsy for Broad Molecular Profiling in Patients With Advanced Non-Small-Cell Lung Cancer.
Jordi Remon, Ludovic Lacroix, +18 authors, Benjamin Besse.
JCO Precis Oncol, 2019 Mar 06; 3. PMID: 32914037    Free PMC article.
Exosome-Reversed Chemoresistance to Cisplatin in Non-Small Lung Cancer Through Transferring miR-613.
Delong Li, Debin Meng, Rungui Niu.
Cancer Manag Res, 2020 Sep 19; 12. PMID: 32943930    Free PMC article.
Predicting Lung Cancer Risk of Incidental Solid and Subsolid Pulmonary Nodules in Different Sizes.
Rui Zhang, Panwen Tian, +2 authors, Weimin Li.
Cancer Manag Res, 2020 Sep 19; 12. PMID: 32943938    Free PMC article.
Intrathoracic core needle biopsy and repeat biopsy for PD-L1 evaluation in non-small cell lung cancer.
Giulia Maria Stella, Chandra Bortolotto, Andrea Riccardo Filippi.
J Thorac Dis, 2019 Jan 12; 10(Suppl 33). PMID: 30631547    Free PMC article.
Determination of PD-L1 Expression in Circulating Tumor Cells of NSCLC Patients and Correlation with Response to PD-1/PD-L1 Inhibitors.
Melanie Janning, Franca Kobus, +19 authors, Sonja Loges.
Cancers (Basel), 2019 Jun 20; 11(6). PMID: 31212989    Free PMC article.
Lgr6: From Stemness to Cancer Progression.
Emanuela Cortesi, Juan-Jose Ventura.
J Lung Health Dis, 2019 Jun 27; 3(1). PMID: 31236545    Free PMC article.
Neutrophil-lymphocyte ratio (NLR) predicted prognosis for advanced non-small-cell lung cancer (NSCLC) patients who received immune checkpoint blockade (ICB).
Fangping Ren, Tian Zhao, Bing Liu, Lei Pan.
Onco Targets Ther, 2019 Jun 27; 12. PMID: 31239702    Free PMC article.
Current perspective on the diagnosis of malignant pleural effusion.
Jun Hyeok Lim, Jeong-Seon Ryu.
J Thorac Dis, 2019 Jun 28; 11(Suppl 9). PMID: 31245095    Free PMC article.
Effects of different metastasis patterns, surgery and other factors on the prognosis of patients with stage IV non-small cell lung cancer: A Surveillance, Epidemiology, and End Results (SEER) linked database analysis.
Yi Liao, Xianming Fan, Xue Wang.
Oncol Lett, 2019 Jul 11; 18(1). PMID: 31289530    Free PMC article.
Characterization of acquired receptor tyrosine-kinase fusions as mechanisms of resistance to EGFR tyrosine-kinase inhibitors.
Haiyuan Xu, Jinge Shen, +7 authors, Yongqian Shu.
Cancer Manag Res, 2019 Aug 03; 11. PMID: 31372039    Free PMC article.
First-line immune checkpoint inhibitors for advanced non-small cell lung cancer with wild-type epidermal growth factor receptor (EGFR) or anaplastic lymphoma kinase (ALK): a systematic review and network meta-analysis.
Tingting Liu, Silu Ding, +3 authors, Guang Li.
J Thorac Dis, 2019 Aug 30; 11(7). PMID: 31463119    Free PMC article.
Integrative gene expression profiling reveals that dysregulated triple microRNAs confer paclitaxel resistance in non-small cell lung cancer via co-targeting MAPT.
Yuanming Cai, Ruxue Jia, +13 authors, Shuiliang Wang.
Cancer Manag Res, 2019 Sep 10; 11. PMID: 31496800    Free PMC article.
MicroRNA-608 Promotes Apoptosis in Non-Small Cell Lung Cancer Cells Treated With Doxorubicin Through the Inhibition of TFAP4.
Yi-Fei Wang, Xiang Ao, +8 authors, Jian-Xun Wang.
Front Genet, 2019 Sep 26; 10. PMID: 31552102    Free PMC article.
The association of PD-L1 expression with the efficacy of anti-PD-1/PD-L1 immunotherapy and survival of non-small cell lung cancer patients: a meta-analysis of randomized controlled trials.
Yangyang Xu, Bing Wan, +13 authors, written on behalf of AME Lung Cancer Collaborative Group.
Transl Lung Cancer Res, 2019 Sep 27; 8(4). PMID: 31555516    Free PMC article.
Cryoablation for advanced non-small cell lung cancer: a protocol for a systematic review.
Hua Duan, Shu-Yue Zheng, +8 authors, Kaiwen Hu.
BMJ Open, 2020 Sep 09; 10(9). PMID: 32895259    Free PMC article.
LncRNA LINC01116 Contributes to Cisplatin Resistance in Lung Adenocarcinoma.
Junbin Wang, Jin Gao, +4 authors, Zhaoxia Wang.
Onco Targets Ther, 2020 Oct 17; 13. PMID: 33061421    Free PMC article.
Mass Spectrometry Imaging for Reliable and Fast Classification of Non-Small Cell Lung Cancer Subtypes.
Mark Kriegsmann, Christiane Zgorzelski, +16 authors, Katharina Kriegsmann.
Cancers (Basel), 2020 Sep 25; 12(9). PMID: 32967325    Free PMC article.
Expression of POU2F3 Transcription Factor Control Inflammation, Immunological Recruitment and Metastasis of Pancreatic Cancer in Mice.
Jennifer Bintz, Analía Meilerman Abuelafia, +5 authors, Juan Iovanna.
Biology (Basel), 2020 Oct 23; 9(10). PMID: 33086657    Free PMC article.
A gene-based survival score for lung adenocarcinoma by multiple transcriptional datasets analysis.
Yanlu Xiong, Jie Lei, +6 authors, Tao Jiang.
BMC Cancer, 2020 Nov 02; 20(1). PMID: 33129284    Free PMC article.
Prognostic factors for survival in patients with metastatic lung adenocarcinoma: An analysis of the SEER database.
Begoña Campos-Balea, Javier de Castro Carpeño, +5 authors, Manuel Cobo Dols.
Thorac Cancer, 2020 Sep 29; 11(11). PMID: 32986309    Free PMC article.
Pearls and pitfalls in lung cancer staging.
Lucian Beer, Ankush Jajodia, Helmut Prosch.
BJR Open, 2020 Nov 13; 2(1). PMID: 33178978    Free PMC article.
Review.
Case Report: A Chronological Combination Treatment of Icotinib, Osimertinib, and Crizotinib on Lung Adenocarcinoma Guided by Serial Genetic Tests of Circulating Tumor DNA and Sediment Cell Genomic DNA From Pleural Effusion.
Zhihua Miao, Tianhao Mu, +12 authors, Xinhua Shu.
Front Oncol, 2020 Nov 17; 10. PMID: 33194628    Free PMC article.
A prognostic model for elderly patients with squamous non-small cell lung cancer: a population-based study.
Siying Chen, Chunxia Gao, +3 authors, Yalin Dong.
J Transl Med, 2020 Nov 18; 18(1). PMID: 33198777    Free PMC article.
Application of "omics" sciences to the prediction of bone metastases from breast cancer: State of the art.
Marica Gentile, Antonella Centonza, +4 authors, Stella D'Oronzo.
J Bone Oncol, 2020 Nov 27; 26. PMID: 33240786    Free PMC article.
Review.
Immunotherapy Moves to the Early-Stage Setting in Non-Small Cell Lung Cancer: Emerging Evidence and the Role of Biomarkers.
Xabier Mielgo-Rubio, Virginia Calvo, +11 authors, Felipe Couñago.
Cancers (Basel), 2020 Nov 26; 12(11). PMID: 33233705    Free PMC article.
Review.
Polymyxin B hemoperfusion in endotoxemic septic shock patients without extreme endotoxemia: a post hoc analysis of the EUPHRATES trial.
D J Klein, D Foster, +3 authors, M Antonelli.
Intensive Care Med, 2018 Nov 25; 44(12). PMID: 30470853    Free PMC article.
Hypoxia‑induced galectin‑3 enhances RhoA function to activate the motility of tumor cells in non‑small cell lung cancer.
Yoko Kataoka, Yasuhiko Ohshio, +3 authors, Jun Hanaoka.
Oncol Rep, 2018 Dec 12; 41(2). PMID: 30535445    Free PMC article.
Chimeric antigen receptor T cell targeting EGFRvIII for metastatic lung cancer therapy.
Zhao Zhang, Jun Jiang, +7 authors, Zhinan Chen.
Front Med, 2019 Feb 06; 13(1). PMID: 30721445
Autophagy inhibition potentiates the anti-angiogenic property of multikinase inhibitor anlotinib through JAK2/STAT3/VEGFA signaling in non-small cell lung cancer cells.
Lijun Liang, Kaiyuan Hui, +12 authors, Xiaodong Jiang.
J Exp Clin Cancer Res, 2019 Feb 14; 38(1). PMID: 30755242    Free PMC article.
Reliability of PD-L1 assays using small tissue samples compared with surgical specimens.
Insu Kim, Ahrong Kim, +10 authors, Jung Seop Eom.
Medicine (Baltimore), 2019 Apr 05; 98(14). PMID: 30946323    Free PMC article.
Notch pathway in small-cell lung cancer: from preclinical evidence to therapeutic challenges.
Alessandro Leonetti, Francesco Facchinetti, +4 authors, Marcello Tiseo.
Cell Oncol (Dordr), 2019 Apr 11; 42(3). PMID: 30968324
Review.
Establishment and validation of a novel survival prediction scoring algorithm for patients with non-small-cell lung cancer spinal metastasis.
Shizhao Zang, Qin He, +2 authors, Weibin Zhang.
Int J Clin Oncol, 2019 Apr 28; 24(9). PMID: 31028506
[Advances of Exosomes Extraction and Its Mechanism in Early Diagnosis of Lung Cancer].
Dan Luo, Chunlei Li, Lun Wu, Qinhua Chen.
Zhongguo Fei Ai Za Zhi, 2020 Aug 06; 23(11). PMID: 32752584    Free PMC article.
LncRNA SNHG20 promoted proliferation, invasion and inhibited cell apoptosis of lung adenocarcinoma via sponging miR-342 and upregulating DDX49.
Xiuli Wang, Guomin Gu, +3 authors, Chunling Liu.
Thorac Cancer, 2020 Oct 23; 11(12). PMID: 33089952    Free PMC article.
LncRNA MALAT1 accelerates non-small cell lung cancer progression via regulating miR-185-5p/MDM4 axis.
Dan Wang, Suhong Zhang, Min Zhao, Fengling Chen.
Cancer Med, 2020 Nov 05; 9(23). PMID: 33146951    Free PMC article.
LINC00857 Interacting with YBX1 to Regulate Apoptosis and Autophagy via MET and Phosphor-AMPKa Signaling.
Wenmei Su, Lihui Wang, +8 authors, Guoan Chen.
Mol Ther Nucleic Acids, 2020 Dec 15; 22. PMID: 33312753    Free PMC article.
Establishment of multiplex allele-specific blocker PCR for enrichment and detection of 4 common EGFR mutations in non-small cell lung cancer.
Hongyuan Chen, Jie Zhang, +2 authors, Daru Lu.
Ann Transl Med, 2020 Dec 15; 8(22). PMID: 33313254    Free PMC article.
Upregulated Collagen COL10A1 Remodels the Extracellular Matrix and Promotes Malignant Progression in Lung Adenocarcinoma.
Yingkuan Liang, Wenjie Xia, +7 authors, Feng Jiang.
Front Oncol, 2020 Dec 17; 10. PMID: 33324550    Free PMC article.
Identifying Cross-Scale Associations between Radiomic and Pathomic Signatures of Non-Small Cell Lung Cancer Subtypes: Preliminary Results.
Charlems Alvarez-Jimenez, Alvaro A Sandino, +3 authors, Eduardo Romero.
Cancers (Basel), 2020 Dec 11; 12(12). PMID: 33297357    Free PMC article.
Lung Adenocarcinoma Mouse Models Based on Orthotopic Transplantation of Syngeneic Tumor-Initiating Cells Expressing EpCAM, SCA-1, and Ly6d.
Takashi Semba, Ryo Sato, +6 authors, Yoshimi Arima.
Cancers (Basel), 2020 Dec 23; 12(12). PMID: 33348616    Free PMC article.
NUCKS1 Promotes Proliferation, Invasion and Migration of Non-Small Cell Lung Cancer by Upregulating CDK1 Expression.
Shufen Zhao, Baiyao Wang, +3 authors, Yawei Yuan.
Cancer Manag Res, 2021 Jan 01; 12. PMID: 33380837    Free PMC article.
Evaluation of cytokines in the tumor microenvironment of lung cancer using bronchoalveolar lavage fluid analysis.
Pascal Bezel, Alan Valaperti, +7 authors, Daniel P Franzen.
Cancer Immunol Immunother, 2021 Jan 05; 70(7). PMID: 33394095
Utilization of circulating cell-free DNA profiling to guide first-line chemotherapy in advanced lung squamous cell carcinoma.
Tao Jiang, Liyan Jiang, +41 authors, Caicun Zhou.
Theranostics, 2021 Jan 05; 11(1). PMID: 33391473    Free PMC article.
Lnc-GAN1 expression is associated with good survival and suppresses tumor progression by sponging mir-26a-5p to activate PTEN signaling in non-small cell lung cancer.
Rui-Qi Wang, Xiao-Ran Long, +8 authors, Hui-Yun Wang.
J Exp Clin Cancer Res, 2021 Jan 08; 40(1). PMID: 33407724    Free PMC article.
IDH1 and IDH2 mutations in lung adenocarcinomas: Evidences of subclonal evolution.
Erika F Rodriguez, Federico De Marchi, +6 authors, Ming-Tseh Li.
Cancer Med, 2020 Apr 26; 9(12). PMID: 32333643    Free PMC article.
Construction of Radiation Surviving/Resistant Lung Cancer Cell Lines with Equidifferent Gradient Dose Irradiation.
Lijuan Wang, Shangbiao Li, Xiaoxia Zhu.
Dose Response, 2021 Jan 12; 18(4). PMID: 33424518    Free PMC article.
Lobaplatin Enhances Radioactive 125I Seed-Induced Apoptosis and Anti-Proliferative Effect in Non-Small Cell Lung Cancer by Suppressing the AKT/mTOR Pathway.
Jia-Hui Rong, Dong Li, Yu-Liang Li.
Onco Targets Ther, 2021 Jan 21; 14. PMID: 33469307    Free PMC article.
A narrative review of evolving roles of radiotherapy in advanced non-small cell lung cancer: from palliative care to active player.
Yue Zhou, Fan Yu, +9 authors, Jianjiao Ni.
Transl Lung Cancer Res, 2021 Jan 26; 9(6). PMID: 33489808    Free PMC article.
Review.
2020 Clinical Practice Guideline for Percutaneous Transthoracic Needle Biopsy of Pulmonary Lesions: A Consensus Statement and Recommendations of the Korean Society of Thoracic Radiology.
Soon Ho Yoon, Sang Min Lee, +15 authors, Chang Min Park.
Korean J Radiol, 2020 Nov 26; 22(2). PMID: 33236542    Free PMC article.
Review.
Systematic construction and validation of an epithelial-mesenchymal transition risk model to predict prognosis of lung adenocarcinoma.
Yunliang Tang, Yanxia Jiang, +2 authors, Zhenguo Zeng.
Aging (Albany NY), 2020 Dec 20; 13(1). PMID: 33340396    Free PMC article.
Application of a treatment planning system-assisted large-aperture computed tomography simulator to percutaneous biopsy: initial experience of a radiation therapist.
Xiaoyi Lin, Liqin Ma, +5 authors, Xiangquan Kong.
J Int Med Res, 2021 Jan 22; 49(1). PMID: 33472476    Free PMC article.
Long non‑coding RNA PITPNA‑AS1 silencing suppresses proliferation, metastasis and epithelial‑mesenchymal transition in non‑small cell lung cancer cells by targeting microRNA‑32‑5p.
Gang Chen, Zhifeng Zheng, +6 authors, Huixin Li.
Mol Med Rep, 2021 Jan 27; 23(3). PMID: 33495838    Free PMC article.
Long-term progression-free survival in a patient with advanced non-small-cell lung cancer treated with low-dose gefitinib and traditional herbal medicine: A case report.
Beom-Joon Lee, Kwan-Il Kim, +2 authors, Jun-Hwan Lee.
Medicine (Baltimore), 2021 Feb 18; 100(5). PMID: 33592873    Free PMC article.
Phosphorylation of SMAD3 in immune cells predicts survival of patients with early stage non-small cell lung cancer.
Sebastian Marwitz, Carmen Ballesteros-Merino, +6 authors, Bernard A Fox.
J Immunother Cancer, 2021 Feb 17; 9(2). PMID: 33589523    Free PMC article.
Survival Outcomes with Photodynamic Therapy, Chemotherapy and Radiation in Patients with Stage III or Stage IV Non-Small Cell Lung Cancer.
Sumedha Chhatre, Anil Vachani, Ron R Allison, Ravishankar Jayadevappa.
Cancers (Basel), 2021 Mar 07; 13(4). PMID: 33671863    Free PMC article.
Identification of a ceRNA Network in Lung Adenocarcinoma Based on Integration Analysis of Tumor-Associated Macrophage Signature Genes.
Lei Zhang, Kai Zhang, +7 authors, Jiaxiang Wang.
Front Cell Dev Biol, 2021 Mar 20; 9. PMID: 33738286    Free PMC article.
Treatment- and immune-related adverse events of immune checkpoint inhibitors in advanced lung cancer.
Jun Shao, Chengdi Wang, +3 authors, Weimin Li.
Biosci Rep, 2020 Apr 22; 40(5). PMID: 32315071    Free PMC article.
Systematic Review.
Enhanced expression of FGF19 predicts poor prognosis in patients with non-small cell lung cancer.
Jia Chen, Jingjing Shao, +5 authors, Yang Ling.
J Thorac Dis, 2021 Apr 13; 13(3). PMID: 33841967    Free PMC article.
A circular network of coregulated sphingolipids dictates lung cancer growth and progression.
Qiong Meng, Xueting Hu, +10 authors, Ping-Pui Wong.
EBioMedicine, 2021 Apr 05; 66. PMID: 33813137    Free PMC article.
Identification of transcriptional subtypes in lung adenocarcinoma and squamous cell carcinoma through integrative analysis of microarray and RNA sequencing data.
François Fauteux, Anuradha Surendra, +2 authors, Jennifer J Hill.
Sci Rep, 2021 Apr 24; 11(1). PMID: 33888829    Free PMC article.
HER2 transmembrane domain mutation: comprehensive characteristics and real-world evidence of treatment response in Chinese lung adenocarcinoma.
Ziqi Jia, Jiahua Xing, +25 authors, Shanqing Li.
Transl Lung Cancer Res, 2021 Apr 24; 10(3). PMID: 33889517    Free PMC article.
The optimal immune checkpoint inhibitors combined with chemotherapy for advanced non-small-cell lung cancer: a systematic review and meta-analysis.
Y Yang, H Luo, X L Zheng, H Ge.
Clin Transl Oncol, 2020 Nov 20; 23(6). PMID: 33211281
Efficacy and acquired resistance for EGFR-TKI plus thoracic SBRT in patients with advanced EGFR-mutant non-small-cell lung cancer: a propensity-matched retrospective study.
Xia Wang, Zhimin Zeng, +4 authors, Anwen Liu.
BMC Cancer, 2021 May 02; 21(1). PMID: 33931014    Free PMC article.
TP53-Activated lncRNA GHRLOS Regulates Cell Proliferation, Invasion, and Apoptosis of Non-Small Cell Lung Cancer by Modulating the miR-346/APC Axis.
Ke Ren, Jinghui Sun, +7 authors, Wei Zhao.
Front Oncol, 2021 May 11; 11. PMID: 33968785    Free PMC article.
EBUS-TBNA Cytological Samples for Comprehensive Molecular Testing in Non-Small Cell Lung Cancer.
Roberto Martin-Deleon, Cristina Teixido, +14 authors, Noemi Reguart.
Cancers (Basel), 2021 May 01; 13(9). PMID: 33923116    Free PMC article.
Comprehensive analysis of tumor microenvironment and identification of an immune signature to predict the prognosis and immunotherapeutic response in lung squamous cell carcinoma.
Jinlong Wu, Chengfeng Xu, +4 authors, Mingsong Wang.
Ann Transl Med, 2021 May 15; 9(7). PMID: 33987267    Free PMC article.
Long non-coding RNA SLC25A25-AS1 exhibits oncogenic roles in non-small cell lung cancer by regulating the microRNA-195-5p/ITGA2 axis.
Jinqin Chen, Chengpeng Gao, Wei Zhu.
Oncol Lett, 2021 Jun 01; 22(1). PMID: 34055094    Free PMC article.
Testing EGFR with Idylla on Cytological Specimens of Lung Cancer: A Review.
Alessandro Caputo, Angela D'Ardia, +4 authors, Antonio D'Antonio.
Int J Mol Sci, 2021 Jun 03; 22(9). PMID: 34063720    Free PMC article.
Review.
Immunotherapy in non-small cell lung cancer: Update and new insights.
Xabier Mielgo-Rubio, Eider Azkona Uribelarrea, Laura Quintanta Cortés, María Sereno Moyano.
J Clin Transl Res, 2021 Jun 10; 7(1). PMID: 34104805    Free PMC article.
Review.
Advances in multimodal treatment for stage IIIA-N2 non-small cell lung cancer.
Sara Montemuiño Muñiz, Soraya Marcos Sánchez, +11 authors, Felipe Couñago.
J Clin Transl Res, 2021 Jun 10; 7(2). PMID: 34104821    Free PMC article.
Review.