Journal Article
. 2017 Oct; 3(12):e173290.
doi: 10.1001/jamaoncol.2017.3290.

Dose-Response Association of CD8+ Tumor-Infiltrating Lymphocytes and Survival Time in High-Grade Serous Ovarian Cancer

Ovarian Tumor Tissue Analysis (OTTA) Consortium  Ellen L Goode 1 Matthew S Block 2 Kimberly R Kalli 2 Robert A Vierkant 1 Wenqian Chen 3 Zachary C Fogarty 1 Aleksandra Gentry-Maharaj 4 Aleksandra Tołoczko 5 Alexander Hein 6 Aliecia L Bouligny 1 Allan Jensen 7 Ana Osorio 8 Andreas Hartkopf 9 Andy Ryan 4 Anita Chudecka-Głaz 10 Anthony M Magliocco 11 Arndt Hartmann 12 Audrey Y Jung 13 Bo Gao 14 Brenda Y Hernandez 15 Brooke L Fridley 16 Bryan M McCauley 1 Catherine J Kennedy 14 Chen Wang 1 Chloe Karpinskyj 4 Christiani B de Sousa 17 Daniel G Tiezzi 17 David L Wachter 12 Esther Herpel 18 Florin Andrei Taran 9 Francesmary Modugno 19 Gregg Nelson 20 Jan Lubiński 5 Janusz Menkiszak 10 Jennifer Alsop 21 Jenny Lester 22 Jesús García-Donas 23 Jill Nation 20 Jillian Hung 14 José Palacios 24 Joseph H Rothstein 25 Joseph L Kelley 19 Jurandyr M de Andrade 17 Luis Robles-Díaz 26 Maria P Intermaggio 27 Martin Widschwendter 4 Matthias W Beckmann 6 Matthias Ruebner 6 Mercedes Jimenez-Linan 28 Naveena Singh 29 Oleg Oszurek 5 Paul R Harnett 14 Peter F Rambau 3 Peter Sinn 30 Philipp Wagner 9 Prafull Ghatage 20 Raghwa Sharma 31 Robert P Edwards 19 Roberta B Ness 32 Sandra Orsulic 22 Sara Y Brucker 9 Sharon E Johnatty 33 Teri A Longacre 34 Eilber Ursula 13 Valerie McGuire 35 Weiva Sieh 25 Yanina Natanzon 1 Zheng Li 1 Alice S Whittemore 36 deFazio Anna 14 Annette Staebler 37 Beth Y Karlan 22 Blake Gilks 38 David D Bowtell 39 Estrid Høgdall 7 Francisco J Candido dos Reis 17 Helen Steed 40 Ian G Campbell 41 Jacek Gronwald 5 Javier Benítez 8 Jennifer M Koziak 42 Jenny Chang-Claude 13 Kirsten B Moysich 43 Linda E Kelemen 44 Linda S Cook 45 Marc T Goodman 46 María José García 8 Peter A Fasching 6 Stefan Kommoss 9 Suha Deen 47 Susanne K Kjaer 7 Usha Menon 4 James D Brenton 48 Paul DP Pharoah 21 Georgia Chenevix-Trench 33 David G Huntsman 49 Stacey J Winham 1 Martin Köbel 3 Susan J Ramus 27 
Affiliations
  • PMID: 29049607
  •     53 References
  •     104 citations

Abstract

Importance: Cytotoxic CD8+ tumor-infiltrating lymphocytes (TILs) participate in immune control of epithelial ovarian cancer; however, little is known about prognostic patterns of CD8+ TILs by histotype and in relation to other clinical factors.

Objective: To define the prognostic role of CD8+ TILs in epithelial ovarian cancer.

Design, Setting, And Participants: This was a multicenter observational, prospective survival cohort study of the Ovarian Tumor Tissue Analysis Consortium. More than 5500 patients, including 3196 with high-grade serous ovarian carcinomas (HGSOCs), were followed prospectively for over 24 650 person-years.

Exposures: Following immunohistochemical analysis, CD8+ TILs were identified within the epithelial components of tumor islets. Patients were grouped based on the estimated number of CD8+ TILs per high-powered field: negative (none), low (1-2), moderate (3-19), and high (≥20). CD8+ TILs in a subset of patients were also assessed in a quantitative, uncategorized manner, and the functional form of associations with survival was assessed using penalized B-splines.

Main Outcomes And Measures: Overall survival time.

Results: The final sample included 5577 women; mean age at diagnosis was 58.4 years (median, 58.2 years). Among the 5 major invasive histotypes, HGSOCs showed the most infiltration. CD8+ TILs in HGSOCs were significantly associated with longer overall survival; median survival was 2.8 years for patients with no CD8+ TILs and 3.0 years, 3.8 years, and 5.1 years for patients with low, moderate, or high levels of CD8+ TILs, respectively (P value for trend = 4.2 × 10−16). A survival benefit was also observed among women with endometrioid and mucinous carcinomas, but not for those with the other histotypes. Among HGSOCs, CD8+ TILs were favorable regardless of extent of residual disease following cytoreduction, known standard treatment, and germline BRCA1 pathogenic mutation, but were not prognostic for BRCA2 mutation carriers. Evaluation of uncategorized CD8+ TIL counts showed a near-log-linear functional form.

Conclusions And Relevance: This study demonstrates the histotype-specific nature of immune infiltration and provides definitive evidence for a dose-response relationship between CD8+ TILs and HGSOC survival. That the extent of infiltration is prognostic, not merely its presence or absence, suggests that understanding factors that drive infiltration will be the key to unraveling outcome heterogeneity in this cancer.

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J Ovarian Res, 2020 May 18; 13(1). PMID: 32414391    Free PMC article.
Sustained response to pembrolizumab without prior chemotherapy in high-grade serous ovarian carcinoma with CSMD3 mutation.
Julie Terzic, Amanda Seipel, +4 authors, S Intidhar Labidi-Galy.
Gynecol Oncol Rep, 2020 Jul 03; 33. PMID: 32613071    Free PMC article.
Clonality and antigen-specific responses shape the prognostic effects of tumor-infiltrating T cells in ovarian cancer.
Takemasa Tsuji, Kevin H Eng, +13 authors, Kunle Odunsi.
Oncotarget, 2020 Jul 18; 11(27). PMID: 32676168    Free PMC article.
Integrated Analysis of Prognostic and Immune Associated Integrin Family in Ovarian Cancer.
Anqi Wu, Sai Zhang, +4 authors, Gang Yin.
Front Genet, 2020 Aug 09; 11. PMID: 32765584    Free PMC article.
Tumor Infiltrating Lymphocytes and CD8+ T Cell Subsets as Prognostic Markers in Patients with Surgically Treated Laryngeal Squamous Cell Carcinoma.
Kyriakos Chatzopoulos, Vassiliki Kotoula, +7 authors, Georgios Fountzilas.
Head Neck Pathol, 2019 Nov 22; 14(3). PMID: 31749124    Free PMC article.
Profound Functional Suppression of Tumor-Infiltrating T-Cells in Ovarian Cancer Patients Can Be Reversed Using PD-1-Blocking Antibodies or DARPin® Proteins.
Emelie Foord, Charlotte Klynning, +13 authors, Michael Uhlin.
J Immunol Res, 2020 Aug 25; 2020. PMID: 32832572    Free PMC article.
Prognostic gene expression signature for high-grade serous ovarian cancer.
J Millstein, T Budden, +122 authors, S J Ramus.
Ann Oncol, 2020 May 31; 31(9). PMID: 32473302    Free PMC article.
Clinical and pathological associations of PTEN expression in ovarian cancer: a multicentre study from the Ovarian Tumour Tissue Analysis Consortium.
Filipe Correia Martins, Dominique-Laurent Couturier, +94 authors, James D Brenton.
Br J Cancer, 2020 Jun 20; 123(5). PMID: 32555365    Free PMC article.
Immune profiling and identification of prognostic immune-related risk factors in human ovarian cancer.
Emelie Rådestad, Charlotte Klynning, +4 authors, Michael Uhlin.
Oncoimmunology, 2019 Feb 05; 8(2). PMID: 30713791    Free PMC article.
The Role of Intra-Tumoral Heterogeneity and Its Clinical Relevance in Epithelial Ovarian Cancer Recurrence and Metastasis.
Cai M Roberts, Carlos Cardenas, Roslyn Tedja.
Cancers (Basel), 2019 Aug 02; 11(8). PMID: 31366178    Free PMC article.
Review.
Patients with BRCA mutated ovarian cancer may have fewer circulating MDSC and more peripheral CD8+ T cells compared with women with BRCA wild-type disease during the early disease course.
Jung-Min Lee, Dana-Adriana Botesteanu, +9 authors, Jane B Trepel.
Oncol Lett, 2019 Sep 14; 18(4). PMID: 31516602    Free PMC article.
Three Genes Predict Prognosis in Microenvironment of Ovarian Cancer.
Ya Guo, Ya Li Wang, +3 authors, Heng Luo.
Front Genet, 2020 Sep 29; 11. PMID: 32983229    Free PMC article.
Are antiangiogenics a good 'partner' for immunotherapy in ovarian cancer?
Elena García-Martínez, Andres Redondo, +2 authors, Antonio Casado.
Angiogenesis, 2020 Jul 22; 23(4). PMID: 32691290    Free PMC article.
Review.
Th17-inducing autologous dendritic cell vaccination promotes antigen-specific cellular and humoral immunity in ovarian cancer patients.
Matthew S Block, Allan B Dietz, +20 authors, Martin J Cannon.
Nat Commun, 2020 Oct 16; 11(1). PMID: 33057068    Free PMC article.
Development and Validation of the Gene Expression Predictor of High-grade Serous Ovarian Carcinoma Molecular SubTYPE (PrOTYPE).
Aline Talhouk, Joshy George, +122 authors, Michael S Anglesio.
Clin Cancer Res, 2020 Jun 20; 26(20). PMID: 32554541    Free PMC article.
MiRNA505/NET1 Axis Acts as a CD8+ T-TIL Regulator in Non-Small Cell Lung Cancer.
Pengyuan Zhu, Zhenchuan Liu, +2 authors, Yongxin Zhou.
Onco Targets Ther, 2020 Oct 17; 13. PMID: 33061457    Free PMC article.
Combined CCNE1 high-level amplification and overexpression is associated with unfavourable outcome in tubo-ovarian high-grade serous carcinoma.
Angela My Chan, Emeka Enwere, +16 authors, Martin Köbel.
J Pathol Clin Res, 2020 May 12; 6(4). PMID: 32391646    Free PMC article.
Epithelial Ovarian Cancer and the Immune System: Biology, Interactions, Challenges and Potential Advances for Immunotherapy.
Anne M Macpherson, Simon C Barry, Carmela Ricciardelli, Martin K Oehler.
J Clin Med, 2020 Sep 18; 9(9). PMID: 32937961    Free PMC article.
Review.
Investigating Patterns of Immune Interaction in Ovarian Cancer: Probing the O-glycoproteome by the Macrophage Galactose-Like C-type Lectin (MGL).
Chiara Napoletano, Catharina Steentoff, +13 authors, Aurelia Rughetti.
Cancers (Basel), 2020 Oct 07; 12(10). PMID: 33019700    Free PMC article.
Identification of serum cytokine clusters associated with outcomes in ovarian clear cell carcinoma.
Akira Yabuno, Hirokazu Matsushita, +8 authors, Kosei Hasegawa.
Sci Rep, 2020 Oct 30; 10(1). PMID: 33116254    Free PMC article.
A cell-of-origin epigenetic tracer reveals clinically distinct subtypes of high-grade serous ovarian cancer.
Pietro Lo Riso, Carlo Emanuele Villa, +19 authors, Giuseppe Testa.
Genome Med, 2020 Oct 31; 12(1). PMID: 33121525    Free PMC article.
Integrated digital pathology and transcriptome analysis identifies molecular mediators of T-cell exclusion in ovarian cancer.
Mélanie Desbois, Akshata R Udyavar, +16 authors, Yulei Wang.
Nat Commun, 2020 Nov 06; 11(1). PMID: 33149148    Free PMC article.
MiRNA-340-5p mediates the functional and infiltrative promotion of tumor-infiltrating CD8+ T lymphocytes in human diffuse large B cell lymphoma.
Yangyang Xu, Zhenchuan Liu, +4 authors, Aibin Liang.
J Exp Clin Cancer Res, 2020 Nov 11; 39(1). PMID: 33168024    Free PMC article.
Prognostic impact of tumor-infiltrating lymphocytes in high grade serous ovarian cancer: a systematic review and meta-analysis.
Jiatao Hao, Hui Yu, +2 authors, Yan Xue.
Ther Adv Med Oncol, 2020 Nov 17; 12. PMID: 33193829    Free PMC article.
Review.
Morphological and molecular heterogeneity of epithelial ovarian cancer: Therapeutic implications.
Ignacio Romero, Susanna Leskelä, +2 authors, José Palacios.
EJC Suppl, 2020 Nov 27; 15. PMID: 33240438    Free PMC article.
The hallmarks of ovarian cancer: Focus on angiogenesis and micro-environment and new models for their characterisation.
V Heredia-Soto, J A López-Guerrero, A Redondo, M Mendiola.
EJC Suppl, 2020 Nov 27; 15. PMID: 33240442    Free PMC article.
Immune Checkpoint Blockade in Gynecologic Cancers: State of Affairs.
Maureen L Drakes, Cheryl M Czerlanis, Patrick J Stiff.
Cancers (Basel), 2020 Nov 14; 12(11). PMID: 33182298    Free PMC article.
Review.
Prognostic relevance of programmed cell death-ligand 1 expression and CD8+ TILs in rectal cancer patients before and after neoadjuvant chemoradiotherapy.
Tsung-Wei Chen, Kevin Chih-Yang Huang, +3 authors, K S Clifford Chao.
J Cancer Res Clin Oncol, 2019 Mar 16; 145(4). PMID: 30874889
Comprehensive analysis of prognostic gene signatures based on immune infiltration of ovarian cancer.
Shibai Yan, Juntao Fang, +4 authors, Feng Fang.
BMC Cancer, 2020 Dec 09; 20(1). PMID: 33287740    Free PMC article.
Immunotherapy Advances for Epithelial Ovarian Cancer.
Erin G Hartnett, Julia Knight, +3 authors, Anda M Vlad.
Cancers (Basel), 2020 Dec 17; 12(12). PMID: 33322601    Free PMC article.
Review.
Hypoxia-Mediated Decrease of Ovarian Cancer Cells Reaction to Treatment: Significance for Chemo- and Immunotherapies.
Aleksandra Klemba, Lubomir Bodnar, +4 authors, Claudine Kieda.
Int J Mol Sci, 2020 Dec 18; 21(24). PMID: 33327450    Free PMC article.
Review.
Changes in the Tumor Immune Microenvironment during Disease Progression in Patients with Ovarian Cancer.
Marie Christine Wulff Westergaard, Katy Milne, +13 authors, Inge Marie Svane.
Cancers (Basel), 2020 Dec 24; 12(12). PMID: 33352957    Free PMC article.
PD-L1 in Combination with CD8+TIL and HIF-1α are Promising Prognosis Predictors of Head and Neck Squamous Cell Carcinoma.
Zihan Zhou, Dianbin Mu, +5 authors, Man Hu.
Cancer Manag Res, 2021 Jan 01; 12. PMID: 33380831    Free PMC article.
Current Ovarian Cancer Maintenance Strategies and Promising New Developments.
Vinaya Gogineni, Susan Morand, +11 authors, John Nemunaitis.
J Cancer, 2021 Jan 05; 12(1). PMID: 33391401    Free PMC article.
Review.
Poor Lymphocyte Infiltration to Primary Tumors in Acral Lentiginous Melanoma and Mucosal Melanoma Compared to Cutaneous Melanoma.
Yoshiyuki Nakamura, Zhu Zhenjie, +5 authors, Yasuhiro Fujisawa.
Front Oncol, 2021 Jan 05; 10. PMID: 33392063    Free PMC article.
Systematic Review.
Tumour infiltrating lymphocytes and PD-L1 expression as potential predictors of outcome in patients with malignant pleural mesothelioma.
N Sobhani, G Roviello, +12 authors, D Generali.
Mol Biol Rep, 2019 Mar 07; 46(3). PMID: 30840203
Indoleamine 2, 3-Dioxygenase 1 and CD8 Expression Profiling Revealed an Immunological Subtype of Colon Cancer With a Poor Prognosis.
Rixin Zhang, Tiegang Li, +6 authors, Min Yang.
Front Oncol, 2021 Jan 12; 10. PMID: 33425745    Free PMC article.
CXCL13 shapes immunoactive tumor microenvironment and enhances the efficacy of PD-1 checkpoint blockade in high-grade serous ovarian cancer.
Moran Yang, Jiaqi Lu, +5 authors, Haiou Liu.
J Immunother Cancer, 2021 Jan 17; 9(1). PMID: 33452206    Free PMC article.
Current and future immunotherapy approaches in ovarian cancer.
Nazım Can Demircan, Stergios Boussios, Tolga Tasci, Mehmet Akif Öztürk.
Ann Transl Med, 2021 Jan 26; 8(24). PMID: 33490226    Free PMC article.
Review.
Emerging Role and Future Directions of Immunotherapy in Advanced Ovarian Cancer.
Thinle Chodon, Amit A Lugade, Sebastiano Battaglia, Kunle Odunsi.
Hematol Oncol Clin North Am, 2018 Nov 06; 32(6). PMID: 30390758    Free PMC article.
Review.
Circulating CD14+ HLA-DRlo/- monocytic cells as a biomarker for epithelial ovarian cancer progression.
Ashley E Stenzel, Scott I Abrams, +19 authors, Kirsten B Moysich.
Am J Reprod Immunol, 2020 Sep 10; 85(3). PMID: 32905653    Free PMC article.
Remission-Stage Ovarian Cancer Cell Vaccine with Cowpea Mosaic Virus Adjuvant Prevents Tumor Growth.
Courtney T Stump, Gregory Ho, +5 authors, Steven Fiering.
Cancers (Basel), 2021 Feb 11; 13(4). PMID: 33562450    Free PMC article.
PD-1 and PD-L1 expression on TILs in peritoneal metastases compared to ovarian tumor tissues and its associations with clinical outcome.
Christine Bekos, Dietmar Pils, +6 authors, Stefanie Aust.
Sci Rep, 2021 Mar 20; 11(1). PMID: 33737722    Free PMC article.
Releasing the brakes of tumor immunity with anti-PD-L1 and pushing its accelerator with L19-IL2 cures poorly immunogenic tumors when combined with radiotherapy.
Veronica Olivo Pimentel, Damiënne Marcus, +8 authors, Philippe Lambin.
J Immunother Cancer, 2021 Mar 11; 9(3). PMID: 33688020    Free PMC article.
The immune landscape during the tumorigenesis of cervical cancer.
Yiying Wang, Mengdi He, +4 authors, Haiou Liu.
Cancer Med, 2021 Mar 12; 10(7). PMID: 33694292    Free PMC article.
Mutations in BRCA1 and BRCA2 differentially affect the tumor microenvironment and response to checkpoint blockade immunotherapy.
Robert M Samstein, Chirag Krishna, +25 authors, Nadeem Riaz.
Nat Cancer, 2021 Apr 10; 1(12). PMID: 33834176    Free PMC article.
High-dimensional analysis of the adenosine pathway in high-grade serous ovarian cancer.
Yacine Bareche, Sandra Pommey, +11 authors, John Stagg.
J Immunother Cancer, 2021 Mar 28; 9(3). PMID: 33771891    Free PMC article.
Impact of tumor heterogeneity and microenvironment in identifying neoantigens in a patient with ovarian cancer.
Tao Dao, Martin G Klatt, +8 authors, David A Scheinberg.
Cancer Immunol Immunother, 2020 Oct 31; 70(5). PMID: 33123756    Free PMC article.
Assessment of Immunological Features in Muscle-Invasive Bladder Cancer Prognosis Using Ensemble Learning.
Christos G Gavriel, Neofytos Dimitriou, +5 authors, Peter D Caie.
Cancers (Basel), 2021 May 01; 13(7). PMID: 33915698    Free PMC article.
T-Cell Receptor Therapy in the Treatment of Ovarian Cancer: A Mini Review.
Jessica W Y Wu, Sudiksha Dand, +4 authors, Joshua D Ooi.
Front Immunol, 2021 May 01; 12. PMID: 33927729    Free PMC article.
Review.
Tumor genomic, transcriptomic, and immune profiling characterizes differential response to first-line platinum chemotherapy in high grade serous ovarian cancer.
Johanne I Weberpals, Trevor J Pugh, +19 authors, Harmanjatinder S Sekhon.
Cancer Med, 2021 Apr 04; 10(9). PMID: 33811746    Free PMC article.
Development and validation of an immune prognostic signature for ovarian carcinoma.
Seema Khadirnaikar, Pranjal Kumar, Sudhanshu Kumar Shukla.
Cancer Rep (Hoboken), 2020 Aug 15; 3(4). PMID: 32794637    Free PMC article.
Combination of Immune-Related Genomic Alterations Reveals Immune Characterization and Prediction of Different Prognostic Risks in Ovarian Cancer.
Xibo Zhao, Shanshan Cong, +4 authors, Guangmei Zhang.
Front Cell Dev Biol, 2021 May 11; 9. PMID: 33968933    Free PMC article.
IDO1 Expression in Ovarian Cancer Induces PD-1 in T Cells via Aryl Hydrocarbon Receptor Activation.
Adaobi Amobi-McCloud, Ravikumar Muthuswamy, +12 authors, Kunle Odunsi.
Front Immunol, 2021 May 25; 12. PMID: 34025677    Free PMC article.
Identification of a Prognostic Signature for Ovarian Cancer Based on the Microenvironment Genes.
Xiao Huo, Hengzi Sun, +4 authors, Shuhong Li.
Front Genet, 2021 Jun 01; 12. PMID: 34054929    Free PMC article.
A Keratin 7 and E-Cadherin Signature Is Highly Predictive of Tubo-Ovarian High-Grade Serous Carcinoma Prognosis.
Laudine Communal, Noemi Roy, +4 authors, Anne-Marie Mes-Masson.
Int J Mol Sci, 2021 Jun 03; 22(10). PMID: 34070214    Free PMC article.
A combination of the immunohistochemical markers CK7 and SATB2 is highly sensitive and specific for distinguishing primary ovarian mucinous tumors from colorectal and appendiceal metastases.
Nicola S Meagher, Linyuan Wang, +79 authors, Martin Köbel.
Mod Pathol, 2019 Jun 27; 32(12). PMID: 31239549    Free PMC article.
Lauren classification identifies distinct prognostic value and functional status of intratumoral CD8+ T cells in gastric cancer.
Ruochen Li, Heng Zhang, +15 authors, Jiejie Xu.
Cancer Immunol Immunother, 2020 Mar 23; 69(7). PMID: 32200421
Spatial cytotoxic and memory T cells in tumor predict superior survival outcomes in patients with high-grade serous ovarian cancer.
Guodong Zhang, Qing Xu, +5 authors, Haiou Liu.
Cancer Med, 2021 May 07; 10(12). PMID: 33955198    Free PMC article.
VISTA: A Promising Target for Cancer Immunotherapy?
Marco Tagliamento, Elisa Agostinetto, +4 authors, Matteo Lambertini.
Immunotargets Ther, 2021 Jul 01; 10. PMID: 34189130    Free PMC article.
Review.
Association of CLDN6 and CLDN10 With Immune Microenvironment in Ovarian Cancer: A Study of the Claudin Family.
Peipei Gao, Ting Peng, +7 authors, Peng Wu.
Front Genet, 2021 Jul 13; 12. PMID: 34249076    Free PMC article.
Predicting Panel of Metabolism and Immune-Related Genes for the Prognosis of Human Ovarian Cancer.
Lingyun Zhang, Wenwen Sun, +2 authors, Guoxiong Xu.
Front Cell Dev Biol, 2021 Jul 30; 9. PMID: 34322485    Free PMC article.
Unraveling tumor-immune heterogeneity in advanced ovarian cancer uncovers immunogenic effect of chemotherapy.
Alejandro Jiménez-Sánchez, Paulina Cybulska, +31 authors, Martin L Miller.
Nat Genet, 2020 Jun 03; 52(6). PMID: 32483290    Free PMC article.
Cell-autonomous inflammation of BRCA1-deficient ovarian cancers drives both tumor-intrinsic immunoreactivity and immune resistance via STING.
Marine Bruand, David Barras, +32 authors, George Coukos.
Cell Rep, 2021 Jul 22; 36(3). PMID: 34289354    Free PMC article.
Application of Immunoprofiling Using Multiplexed Immunofluorescence Staining Identifies the Prognosis of Patients with High-Grade Serous Ovarian Cancer.
Shin-Wha Lee, Ha-Young Lee, +4 authors, Yong-Man Kim.
Int J Mol Sci, 2021 Sep 11; 22(17). PMID: 34502561    Free PMC article.
Effect of MAP3K8 on Prognosis and Tumor-Related Inflammation in Renal Clear Cell Carcinoma.
Jiatao Hao, Yumeng Cao, +3 authors, Yan Xue.
Front Genet, 2021 Sep 28; 12. PMID: 34567061    Free PMC article.
Upregulated Expression of CYBRD1 Predicts Poor Prognosis of Patients with Ovarian Cancer.
Rui Chen, Jianhong Cao, +2 authors, Jingxin Cheng.
J Oncol, 2021 Oct 02; 2021. PMID: 34594380    Free PMC article.
SLFN11 captures cancer-immunity interactions associated with platinum sensitivity in high-grade serous ovarian cancer.
Claudia Winkler, Matthew King, +13 authors, Gabriele Zoppoli.
JCI Insight, 2021 Sep 23; 6(18). PMID: 34549724    Free PMC article.
Immunological configuration of ovarian carcinoma: features and impact on disease outcome.
Jitka Fucikova, An Coosemans, +4 authors, Radek Spisek.
J Immunother Cancer, 2021 Oct 15; 9(10). PMID: 34645669    Free PMC article.
Review.