Review
. 2017 Oct; 17(12):725-737.
doi: 10.1038/nrc.2017.87.

Small-cell lung cancer: what we know, what we need to know and the path forward

Adi F Gazdar 1 Paul A Bunn 2 John D Minna 1 
Affiliations
  • PMID: 29077690
  •     177 References
  •     139 citations

Abstract

Small-cell lung cancer (SCLC) is a deadly tumour accounting for approximately 15% of lung cancers and is pathologically, molecularly, biologically and clinically very different from other lung cancers. While the majority of tumours express a neuroendocrine programme (integrating neural and endocrine properties), an important subset of tumours have low or absent expression of this programme. The probable initiating molecular events are inactivation of TP53 and RB1, as well as frequent disruption of several signalling networks, including Notch signalling. SCLC, when diagnosed, is usually widely metastatic and initially responds to cytotoxic therapy but nearly always rapidly relapses with resistance to further therapies. There were no important therapeutic clinical advances for 30 years, leading SCLC to be designated a 'recalcitrant cancer'. Scientific studies are hampered by a lack of tissue availability. However, over the past 5 years, there has been a worldwide resurgence of studies on SCLC, including comprehensive molecular analyses, the development of relevant genetically engineered mouse models and the establishment of patient-derived xenografts. These studies have led to the discovery of new potential therapeutic vulnerabilities for SCLC and therefore to new clinical trials. Thus, while the past has been bleak, the future offers greater promise.

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C Allison Stewart, Pan Tong, +19 authors, Lauren Averett Byers.
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Paraneoplastic syndromes: the way to an early diagnosis of lung cancer.
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The 630-kb lung cancer homozygous deletion region on human chromosome 3p21.3: identification and evaluation of the resident candidate tumor suppressor genes. The International Lung Cancer Chromosome 3p21.3 Tumor Suppressor Gene Consortium.
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PTEN is a potent suppressor of small cell lung cancer.
Min Cui, Arnaud Augert, +5 authors, David MacPherson.
Mol Cancer Res, 2014 Feb 01; 12(5). PMID: 24482365    Free PMC article.
New metastatic model of human small-cell lung cancer by orthotopic transplantation in mice.
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Front Biosci (Elite Ed), 2013 Jun 12; 5. PMID: 23747909
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Ludmil B Alexandrov, Serena Nik-Zainal, +72 authors, Michael R Stratton.
Nature, 2013 Aug 16; 500(7463). PMID: 23945592    Free PMC article.
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NFIB overexpression cooperates with Rb/p53 deletion to promote small cell lung cancer.
Nan Wu, Deshui Jia, +3 authors, David MacPherson.
Oncotarget, 2016 Sep 11; 7(36). PMID: 27613844    Free PMC article.
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J Thorac Oncol, 2013 Jan 19; 8(2). PMID: 23328545
The DNA methylation landscape of small cell lung cancer suggests a differentiation defect of neuroendocrine cells.
S Kalari, M Jung, +2 authors, G P Pfeifer.
Oncogene, 2012 Aug 22; 32(30). PMID: 22907430    Free PMC article.
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Mol Cancer Res, 2013 Mar 02; 11(6). PMID: 23449933    Free PMC article.
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Cancer Therapy Due to Apoptosis: Galectin-9.
Koji Fujita, Hisakazu Iwama, +10 authors, Tsutomu Masaki.
Int J Mol Sci, 2017 Jan 04; 18(1). PMID: 28045432    Free PMC article.
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John D Minna, Jane E Johnson.
Cell, 2016 Jul 16; 166(2). PMID: 27419866    Free PMC article.
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Possible roles of DLK1 in the Notch pathway during development and disease.
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Rovalpituzumab tesirine, a DLL3-targeted antibody-drug conjugate, in recurrent small-cell lung cancer: a first-in-human, first-in-class, open-label, phase 1 study.
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Lancet Oncol, 2016 Dec 10; 18(1). PMID: 27932068    Free PMC article.
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EZH2 promotes progression of small cell lung cancer by suppressing the TGF-β-Smad-ASCL1 pathway.
Fumihiko Murai, Daizo Koinuma, +3 authors, Shogo Ehata.
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The serum-free establishment and in vitro growth properties of classic and variant small cell lung cancer cell lines.
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Ralph Meuwissen, Anton Berns.
Genes Dev, 2005 Mar 17; 19(6). PMID: 15769940
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Long noncoding RNA-HOTAIR affects chemoresistance by regulating HOXA1 methylation in small cell lung cancer cells.
Shun Fang, Hongyi Gao, +5 authors, Linlang Guo.
Lab Invest, 2015 Dec 29; 96(1). PMID: 26707824
Small Cell Lung Cancer: Can Recent Advances in Biology and Molecular Biology Be Translated into Improved Outcomes?
Paul A Bunn, John D Minna, +51 authors, Fred R Hirsch.
J Thorac Oncol, 2016 Feb 02; 11(4). PMID: 26829312    Free PMC article.
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Awakening of "Schlafen11" to Tackle Chemotherapy Resistance in SCLC.
Katrien Berns, Anton Berns.
Cancer Cell, 2017 Feb 16; 31(2). PMID: 28196592
Role of EZH2 in cancer stem cells: from biological insight to a therapeutic target.
Yiping Wen, Jing Cai, +2 authors, Zehua Wang.
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Mutational signatures associated with tobacco smoking in human cancer.
Ludmil B Alexandrov, Young Seok Ju, +11 authors, Michael R Stratton.
Science, 2016 Nov 05; 354(6312). PMID: 27811275    Free PMC article.
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The schlafen family of proteins and their regulation by interferons.
Evangelos Mavrommatis, Eleanor N Fish, Leonidas C Platanias.
J Interferon Cytokine Res, 2013 Apr 11; 33(4). PMID: 23570387    Free PMC article.
Genotypic and histological evolution of lung cancers acquiring resistance to EGFR inhibitors.
Lecia V Sequist, Belinda A Waltman, +19 authors, Jeffrey A Engelman.
Sci Transl Med, 2011 Mar 25; 3(75). PMID: 21430269    Free PMC article.
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Bromodomain and hedgehog pathway targets in small cell lung cancer.
Gurmeet Kaur, Russell A Reinhart, +4 authors, Beverly A Teicher.
Cancer Lett, 2015 Dec 20; 371(2). PMID: 26683772    Free PMC article.
Roles of the EZH2 histone methyltransferase in cancer epigenetics.
Jeffrey A Simon, Carol A Lange.
Mutat Res, 2008 Aug 30; 647(1-2). PMID: 18723033
Highly Cited. Review.
Cell of origin of small cell lung cancer: inactivation of Trp53 and Rb1 in distinct cell types of adult mouse lung.
Kate D Sutherland, Natalie Proost, +3 authors, Anton Berns.
Cancer Cell, 2011 Jun 15; 19(6). PMID: 21665149
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Prognostic value of high EZH2 expression in patients with different types of cancer: a systematic review with meta-analysis.
Tao Jiang, Yan Wang, +3 authors, Caicun Zhou.
Oncotarget, 2015 Dec 20; 7(4). PMID: 26683709    Free PMC article.
Systematic Review.
5-hydroxytryptophan uptake by dog thyroid 'C' cells, and its possible significance in polypeptide hormone production.
A G Pearse.
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Methylation of SLFN11 is a marker of poor prognosis and cisplatin resistance in colorectal cancer.
Tao He, Meiying Zhang, +4 authors, Mingzhou Guo.
Epigenomics, 2017 Apr 14; 9(6). PMID: 28403629
Genetic and clonal dissection of murine small cell lung carcinoma progression by genome sequencing.
David G McFadden, Thales Papagiannakopoulos, +18 authors, Tyler Jacks.
Cell, 2014 Mar 19; 156(6). PMID: 24630729    Free PMC article.
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A genetic snapshot of small cell lung cancer.
Rafael Rosell, Luciano Wannesson.
Cancer Discov, 2012 Sep 13; 2(9). PMID: 22969115
Long non-coding RNA TUG1 is involved in cell growth and chemoresistance of small cell lung cancer by regulating LIMK2b via EZH2.
Yuchun Niu, Feng Ma, +4 authors, Linlang Guo.
Mol Cancer, 2017 Jan 11; 16(1). PMID: 28069000    Free PMC article.
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Establishment and identification of small cell lung cancer cell lines having classic and variant features.
D N Carney, A F Gazdar, +5 authors, J D Minna.
Cancer Res, 1985 Jun 01; 45(6). PMID: 2985257
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MAX inactivation in small cell lung cancer disrupts MYC-SWI/SNF programs and is synthetic lethal with BRG1.
Octavio A Romero, Manuel Torres-Diz, +10 authors, Montse Sanchez-Cespedes.
Cancer Discov, 2013 Dec 24; 4(3). PMID: 24362264
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R M Phelps, B E Johnson, +9 authors, J L Mulshine.
J Cell Biochem Suppl, 1996 Jan 01; 24. PMID: 8806092
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ITPKA Gene Body Methylation Regulates Gene Expression and Serves as an Early Diagnostic Marker in Lung and Other Cancers.
Yi-Wei Wang, Xiaotu Ma, +6 authors, Adi F Gazdar.
J Thorac Oncol, 2016 May 29; 11(9). PMID: 27234602    Free PMC article.
Preclinical Murine Models for Lung Cancer: Clinical Trial Applications.
Amelia Kellar, Cay Egan, Don Morris.
Biomed Res Int, 2015 Jun 13; 2015. PMID: 26064932    Free PMC article.
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myc family DNA amplification in tumors and tumor cell lines from patients with small-cell lung cancer.
B E Johnson, J F Brennan, D C Ihde, A F Gazdar.
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Is the Canonical RAF/MEK/ERK Signaling Pathway a Therapeutic Target in SCLC?
Sandra Cristea, Julien Sage.
J Thorac Oncol, 2016 May 03; 11(8). PMID: 27133774    Free PMC article.
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Immunotherapy for small-cell lung cancer: emerging evidence.
Martin Reck, David Heigener, Niels Reinmuth.
Future Oncol, 2016 Feb 18; 12(7). PMID: 26882955
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Functional analysis of lung tumor suppressor activity at 3p21.3.
Arja ter Elst, Bea E Hiemstra, +8 authors, Charles H C M Buys.
Genes Chromosomes Cancer, 2006 Sep 08; 45(12). PMID: 16958100
An APOBEC cytidine deaminase mutagenesis pattern is widespread in human cancers.
Steven A Roberts, Michael S Lawrence, +12 authors, Dmitry A Gordenin.
Nat Genet, 2013 Jul 16; 45(9). PMID: 23852170    Free PMC article.
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A DLL3-targeted antibody-drug conjugate eradicates high-grade pulmonary neuroendocrine tumor-initiating cells in vivo.
Laura R Saunders, Alexander J Bankovich, +30 authors, Scott J Dylla.
Sci Transl Med, 2015 Aug 28; 7(302). PMID: 26311731    Free PMC article.
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Genomic landscape of non-small cell lung cancer in smokers and never-smokers.
Ramaswamy Govindan, Li Ding, +18 authors, Richard K Wilson.
Cell, 2012 Sep 18; 150(6). PMID: 22980976    Free PMC article.
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Molecular analysis of the von Hippel-Lindau disease tumor suppressor gene in human lung cancer cell lines.
Y Sekido, S Bader, +6 authors, J D Minna.
Oncogene, 1994 Jun 01; 9(6). PMID: 8183553
Genetically engineered mouse models: closing the gap between preclinical data and trial outcomes.
Mallika Singh, Christopher L Murriel, Leisa Johnson.
Cancer Res, 2012 May 18; 72(11). PMID: 22593194
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RB loss in resistant EGFR mutant lung adenocarcinomas that transform to small-cell lung cancer.
Matthew J Niederst, Lecia V Sequist, +24 authors, Jeffrey A Engelman.
Nat Commun, 2015 Mar 12; 6. PMID: 25758528    Free PMC article.
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Transcription Factor NFIB Is a Driver of Small Cell Lung Cancer Progression in Mice and Marks Metastatic Disease in Patients.
Ekaterina A Semenova, Min-Chul Kwon, +17 authors, Anton Berns.
Cell Rep, 2016 Jul 05; 16(3). PMID: 27373156    Free PMC article.
TTF1 expression in normal lung neuroendocrine cells and related tumors: immunohistochemical study comparing two different monoclonal antibodies.
Stefano La Rosa, Anna Maria Chiaravalli, +3 authors, Carlo Capella.
Virchows Arch, 2010 Aug 10; 457(4). PMID: 20694477
MYC amplification is associated with poor survival in small cell lung cancer: a chromogenic in situ hybridization study.
Rita de Cássia S Alves, Rosalva Thereza Meurer, Adriana Vial Roehe.
J Cancer Res Clin Oncol, 2014 Jul 12; 140(12). PMID: 25012251
Induction of small cell lung cancer by somatic inactivation of both Trp53 and Rb1 in a conditional mouse model.
Ralph Meuwissen, Sabine C Linn, +3 authors, Anton Berns.
Cancer Cell, 2003 Oct 03; 4(3). PMID: 14522252
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Lung cancer-initiating cells: a novel target for cancer therapy.
Brian J Morrison, John C Morris, Jason C Steel.
Target Oncol, 2013 Jan 15; 8(3). PMID: 23314952    Free PMC article.
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Cancer stem cells in small cell lung cancer.
Jordi Codony-Servat, Alberto Verlicchi, Rafael Rosell.
Transl Lung Cancer Res, 2016 Mar 10; 5(1). PMID: 26958490    Free PMC article.
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Cancer stem cells and tumor transdifferentiation: implications for novel therapeutic strategies.
Mohammed Talha Shekhani, Ashika-Sita Jayanthy, Nityanand Maddodi, Vijayasaradhi Setaluri.
Am J Stem Cells, 2013 May 15; 2(1). PMID: 23671816    Free PMC article.
High resolution chromosome 3p allelotyping of human lung cancer and preneoplastic/preinvasive bronchial epithelium reveals multiple, discontinuous sites of 3p allele loss and three regions of frequent breakpoints.
I I Wistuba, C Behrens, +11 authors, J D Minna.
Cancer Res, 2000 Apr 15; 60(7). PMID: 10766185
A framework for identification of actionable cancer genome dependencies in small cell lung cancer.
Martin L Sos, Felix Dietlein, +20 authors, Roman K Thomas.
Proc Natl Acad Sci U S A, 2012 Oct 05; 109(42). PMID: 23035247    Free PMC article.
myc family DNA amplification in 107 tumors and tumor cell lines from patients with small cell lung cancer treated with different combination chemotherapy regimens.
J Brennan, T O'Connor, +7 authors, B E Johnson.
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Proteomic profiling identifies dysregulated pathways in small cell lung cancer and novel therapeutic targets including PARP1.
Lauren Averett Byers, Jing Wang, +25 authors, John V Heymach.
Cancer Discov, 2012 Sep 11; 2(9). PMID: 22961666    Free PMC article.
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Lambert-Eaton myasthenic syndrome: from clinical characteristics to therapeutic strategies.
Maarten J Titulaer, Bethan Lang, Jan Jgm Verschuuren.
Lancet Neurol, 2011 Nov 19; 10(12). PMID: 22094130
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Next-Generation Sequencing of Pulmonary Large Cell Neuroendocrine Carcinoma Reveals Small Cell Carcinoma-like and Non-Small Cell Carcinoma-like Subsets.
Natasha Rekhtman, Maria C Pietanza, +17 authors, Marc Ladanyi.
Clin Cancer Res, 2016 Mar 11; 22(14). PMID: 26960398    Free PMC article.
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Comprehensive genomic analysis identifies SOX2 as a frequently amplified gene in small-cell lung cancer.
Charles M Rudin, Steffen Durinck, +34 authors, Somasekar Seshagiri.
Nat Genet, 2012 Sep 04; 44(10). PMID: 22941189    Free PMC article.
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HDAC inhibitors suppressed small cell lung cancer cell growth and enhanced the suppressive effects of receptor-targeting cytotoxins via upregulating somatostatin receptor II.
Lichun Sun, Quanyong He, +4 authors, David H Coy.
Am J Transl Res, 2018 Mar 08; 10(2). PMID: 29511449    Free PMC article.
Long non-coding RNA linc01433 promotes migration and invasion in non-small cell lung cancer.
Banglun Qian, Xiang Wang, +8 authors, Hongcan Shi.
Thorac Cancer, 2018 Mar 14; 9(5). PMID: 29532622    Free PMC article.
Small cell lung cancer: updates and new concepts.
Peter Ujhazy, O Wolf Lindwasser.
Transl Lung Cancer Res, 2018 Mar 15; 7(1). PMID: 29535908    Free PMC article.
Targeting DNA damage repair in small cell lung cancer and the biomarker landscape.
Triparna Sen, Carl M Gay, Lauren Averett Byers.
Transl Lung Cancer Res, 2018 Mar 15; 7(1). PMID: 29535912    Free PMC article.
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Function of Tumor Suppressors in Resistance to Antiandrogen Therapy and Luminal Epithelial Plasticity of Aggressive Variant Neuroendocrine Prostate Cancers.
Rama Soundararajan, Ana M Aparicio, +2 authors, Sankar N Maity.
Front Oncol, 2018 Mar 31; 8. PMID: 29600194    Free PMC article.
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Intratumoral heterogeneity of Notch1 expression in small cell lung cancer.
Takaaki Ito.
J Thorac Dis, 2018 May 01; 10(3). PMID: 29707277    Free PMC article.
Sodium Valproate Inhibits Small Cell Lung Cancer Tumor Growth on the Chicken Embryo Chorioallantoic Membrane and Reduces the p53 and EZH2 Expression.
Lina Šlekienė, Donatas Stakišaitis, Ingrida Balnytė, Angelija Valančiūtė.
Dose Response, 2018 May 16; 16(2). PMID: 29760602    Free PMC article.
Managing Patients With Relapsed Small-Cell Lung Cancer.
Jun Gong, Ravi Salgia.
J Oncol Pract, 2018 Jun 13; 14(6). PMID: 29894664    Free PMC article.
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POU2F3 is a master regulator of a tuft cell-like variant of small cell lung cancer.
Yu-Han Huang, Olaf Klingbeil, +11 authors, Christopher R Vakoc.
Genes Dev, 2018 Jun 28; 32(13-14). PMID: 29945888    Free PMC article.
Highly Cited.
Identifying a missing lineage driver in a subset of lung neuroendocrine tumors.
Karine Pozo, John D Minna, Jane E Johnson.
Genes Dev, 2018 Jul 04; 32(13-14). PMID: 29967289    Free PMC article.
Complete response to ipilimumab and nivolumab therapy in a patient with extensive extrapulmonary high-grade small cell carcinoma of the pancreas and HIV infection.
Muhammad Husnain, Wungki Park, +5 authors, Peter J Hosein.
J Immunother Cancer, 2018 Jul 11; 6(1). PMID: 29986769    Free PMC article.
Crebbp Loss Drives Small Cell Lung Cancer and Increases Sensitivity to HDAC Inhibition.
Deshui Jia, Arnaud Augert, +10 authors, David MacPherson.
Cancer Discov, 2018 Sep 06; 8(11). PMID: 30181244    Free PMC article.
Autochthonous murine models for the study of smoker and never-smoker associated lung cancers.
Esra A Akbay, James Kim.
Transl Lung Cancer Res, 2018 Sep 19; 7(4). PMID: 30225211    Free PMC article.
Review.
Prognostic significance of the 8th edition of the TNM classification for patients with extensive disease small cell lung cancer.
Masayuki Shirasawa, Tomoya Fukui, +12 authors, Katsuhiko Naoki.
Cancer Manag Res, 2018 Dec 13; 10. PMID: 30538553    Free PMC article.
A high-throughput drug screen identifies auranofin as a potential sensitizer of cisplatin in small cell lung cancer.
Xiaoli Liu, Wei Wang, +7 authors, Wenchu Lin.
Invest New Drugs, 2019 Mar 03; 37(6). PMID: 30825105
Soluble fms-like tyrosine kinase-1-enriched exosomes suppress the growth of small cell lung cancer by inhibiting endothelial cell migration.
Dexun Hao, Yanshuang Li, Gaofeng Zhao, Mingzhi Zhang.
Thorac Cancer, 2019 Aug 24; 10(10). PMID: 31441580    Free PMC article.
Targeting DNA Replication Stress and DNA Double-Strand Break Repair for Optimizing SCLC Treatment.
Xing Bian, Wenchu Lin.
Cancers (Basel), 2019 Sep 05; 11(9). PMID: 31480716    Free PMC article.
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Pathological transition as the arising mechanism for drug resistance in lung cancer.
Yueqing Chen, Waiying Yvonne Tang, Xinyuan Tong, Hongbin Ji.
Cancer Commun (Lond), 2019 Oct 02; 39(1). PMID: 31570104    Free PMC article.
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HE4 as a biomarker for diagnosis of lung cancer: A meta-analysis.
Yong-Peng He, Li-Xian Li, +8 authors, Lin Gan.
Medicine (Baltimore), 2019 Oct 03; 98(39). PMID: 31574828    Free PMC article.
Long non-coding RNA transcribed from pseudogene PPIAP43 is associated with radiation sensitivity of small cell lung cancer cells.
Shilong Wang, Jinming Yu.
Oncol Lett, 2019 Oct 16; 18(5). PMID: 31611966    Free PMC article.
Prognostic impact of tumor mutation burden and the mutation in KIAA1211 in small cell lung cancer.
Mengting Zhou, Jun Fan, +10 authors, Fred R Hirsch.
Respir Res, 2019 Nov 09; 20(1). PMID: 31699089    Free PMC article.
Tumor Mutational Burden and Genomic Alterations in Chinese Small Cell Lung Cancer Measured by Whole-Exome Sequencing.
Shan Su, Jian-Jun Zou, +14 authors, Jian-Xiong Liu.
Biomed Res Int, 2019 Nov 30; 2019. PMID: 31781628    Free PMC article.
A Review on Curability of Cancers: More Efforts for Novel Therapeutic Options Are Needed.
Shuncong Wang, Yewei Liu, +4 authors, Yicheng Ni.
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LncRNA LUADT1 sponges miR-15a-3p to upregulate Twist1 in small cell lung cancer.
Dingxue Wang, Wenyu Wu, +3 authors, Dongxin Tang.
BMC Pulm Med, 2019 Dec 18; 19(1). PMID: 31842825    Free PMC article.
Polymorphism in ASCL1 target gene DDC is associated with clinical outcomes of small cell lung cancer patients.
Ji Hyun Kim, Shin Yup Lee, +15 authors, Jae Yong Park.
Thorac Cancer, 2019 Nov 07; 11(1). PMID: 31691490    Free PMC article.
A Meta-Analysis of the Efficacy and Toxicity of Twice-Daily vs. Once-Daily Concurrent Chemoradiotherapy for Limited-Stage Small Cell Lung Cancer Based on Randomized Controlled Trials.
Qian Wu, Yiting Xiong, +4 authors, Wenxiong Zhang.
Front Oncol, 2020 Jan 24; 9. PMID: 31970086    Free PMC article.
Systematic Review.
Comparative analysis of TTF-1 binding DNA regions in small-cell lung cancer and non-small-cell lung cancer.
Satoshi Hokari, Yusuke Tamura, +10 authors, Daizo Koinuma.
Mol Oncol, 2019 Nov 30; 14(2). PMID: 31782890    Free PMC article.
A 10-year prediagnostic follow-up study shows that serum RNA signals are highly dynamic in lung carcinogenesis.
Sinan Uğur Umu, Hilde Langseth, +4 authors, Trine B Rounge.
Mol Oncol, 2019 Dec 19; 14(2). PMID: 31851411    Free PMC article.
Comparative expression analysis in small cell lung carcinoma reveals neuroendocrine pattern change in primary tumor versus lymph node metastases.
Zoltan Lohinai, Zsolt Megyesfalvi, +7 authors, Fred R Hirsch.
Transl Lung Cancer Res, 2020 Feb 06; 8(6). PMID: 32010572    Free PMC article.
Profiling of Circulating Free DNA Using Targeted and Genome-wide Sequencing in Patients with SCLC.
Sumitra Mohan, Victoria Foy, +16 authors, Gerard Brady.
J Thorac Oncol, 2019 Oct 20; 15(2). PMID: 31629061    Free PMC article.
Osteopontin Mediates Cetuximab Resistance via the MAPK Pathway in NSCLC Cells.
Jian Cui, Jun Wang, +2 authors, Wei Zuo.
Onco Targets Ther, 2020 Feb 18; 12. PMID: 32063712    Free PMC article.
Machine Learning and Bioinformatics Models to Identify Pathways that Mediate Influences of Welding Fumes on Cancer Progression.
Humayan Kabir Rana, Mst Rashida Akhtar, +5 authors, Mohammad Ali Moni.
Sci Rep, 2020 Feb 19; 10(1). PMID: 32066756    Free PMC article.
IRS2 Amplification as a Predictive Biomarker in Response to Ceritinib in Small Cell Lung Cancer.
Mi-Sook Lee, Kyungsoo Jung, +5 authors, Yoon-La Choi.
Mol Ther Oncolytics, 2020 Feb 27; 16. PMID: 32099898    Free PMC article.
Tumor Heterogeneity Underlies Differential Cisplatin Sensitivity in Mouse Models of Small-Cell Lung Cancer.
Franziska Böttger, Ekaterina A Semenova, +9 authors, Anton Berns.
Cell Rep, 2019 Jun 13; 27(11). PMID: 31189116    Free PMC article.
MicroRNA-485-5p suppresses the proliferation, migration and invasion of small cell lung cancer cells by targeting flotillin-2.
Feng Gao, Hao Wu, +6 authors, Junfeng Liu.
Bioengineered, 2019 Mar 07; 10(1). PMID: 30836864    Free PMC article.
A gapmer antisense oligonucleotide targeting SRRM4 is a novel therapeutic medicine for lung cancer.
Masahito Shimojo, Yuuya Kasahara, +4 authors, Satoshi Obika.
Sci Rep, 2019 May 22; 9(1). PMID: 31110284    Free PMC article.
Carcinogenesis and Reactive Oxygen Species Signaling: Interaction of the NADPH Oxidase NOX1-5 and Superoxide Dismutase 1-3 Signal Transduction Pathways.
Alessia Parascandolo, Mikko O Laukkanen.
Antioxid Redox Signal, 2018 Feb 27; 30(3). PMID: 29478325    Free PMC article.
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Overcoming T790M mutant small cell lung cancer with the third-generation EGFR-TKI osimertinib.
Kejing Tang, Neng Jiang, +12 authors, Zunfu Ke.
Thorac Cancer, 2018 Dec 07; 10(2). PMID: 30521113    Free PMC article.
Molecular characterisation and liquid biomarkers in Carcinoma of Unknown Primary (CUP): taking the 'U' out of 'CUP'.
Alicia-Marie Conway, Claire Mitchell, +3 authors, Natalie Cook.
Br J Cancer, 2018 Dec 24; 120(2). PMID: 30580378    Free PMC article.
Review.
Targeting NOTCH activation in small cell lung cancer through LSD1 inhibition.
Arnaud Augert, Emily Eastwood, +12 authors, David MacPherson.
Sci Signal, 2019 Feb 07; 12(567). PMID: 30723171    Free PMC article.
Highly Cited.
Generation of pulmonary neuroendocrine cells and SCLC-like tumors from human embryonic stem cells.
Huanhuan Joyce Chen, Asaf Poran, +4 authors, Harold Varmus.
J Exp Med, 2019 Feb 10; 216(3). PMID: 30737256    Free PMC article.
Small cell lung cancers made from scratch.
Adi F Gazdar, John D Minna.
J Exp Med, 2019 Feb 15; 216(3). PMID: 30760489    Free PMC article.
Adjudin synergizes with paclitaxel and inhibits cell growth and metastasis by regulating the sirtuin 3-Forkhead box O3a axis in human small-cell lung cancer.
Xue Wang, Qingyu Zeng, +3 authors, Zhiwei Chen.
Thorac Cancer, 2019 Feb 20; 10(4). PMID: 30779316    Free PMC article.
Molecular subtypes of small cell lung cancer: a synthesis of human and mouse model data.
Charles M Rudin, John T Poirier, +15 authors, Adi F Gazdar.
Nat Rev Cancer, 2019 Mar 31; 19(5). PMID: 30926931    Free PMC article.
Highly Cited. Review.
Prognostic differences between oligometastatic and polymetastatic extensive disease-small cell lung cancer.
Masayuki Shirasawa, Tomoya Fukui, +12 authors, Katsuhiko Naoki.
PLoS One, 2019 Apr 20; 14(4). PMID: 31002722    Free PMC article.
Durvalumab in Combination with Olaparib in Patients with Relapsed SCLC: Results from a Phase II Study.
Anish Thomas, Rasa Vilimas, +19 authors, Jung-Min Lee.
J Thorac Oncol, 2019 May 08; 14(8). PMID: 31063862    Free PMC article.
Highly Cited.
Subtype-specific secretomic characterization of pulmonary neuroendocrine tumor cells.
Xu-Dong Wang, Rongkuan Hu, +7 authors, Yonghao Yu.
Nat Commun, 2019 Jul 22; 10(1). PMID: 31324758    Free PMC article.
Systems-level network modeling of Small Cell Lung Cancer subtypes identifies master regulators and destabilizers.
David J Wooten, Sarah M Groves, +6 authors, Vito Quaranta.
PLoS Comput Biol, 2019 Nov 02; 15(10). PMID: 31671086    Free PMC article.
A Summary of In Vitro and In Vivo Studies Evaluating the Impact of E-Cigarette Exposure on Living Organisms and the Environment.
Anna Merecz-Sadowska, Przemyslaw Sitarek, +4 authors, Radoslaw Zajdel.
Int J Mol Sci, 2020 Jan 23; 21(2). PMID: 31963832    Free PMC article.
Review.
Cell Cycle and Beyond: Exploiting New RB1 Controlled Mechanisms for Cancer Therapy.
Erik S Knudsen, Steven C Pruitt, +2 authors, David W Goodrich.
Trends Cancer, 2019 Jun 09; 5(5). PMID: 31174843    Free PMC article.
Review.
A shift in glutamine nitrogen metabolism contributes to the malignant progression of cancer.
Manabu Kodama, Kiyotaka Oshikawa, +8 authors, Keiichi I Nakayama.
Nat Commun, 2020 Mar 19; 11(1). PMID: 32184390    Free PMC article.
High Systemic Immune-Inflammation Index (SII) Represents an Unfavorable Prognostic Factor for Small Cell Lung Cancer Treated with Etoposide and Platinum-Based Chemotherapy.
Chunyan Wang, Shi Jin, Shanqi Xu, Shoubo Cao.
Lung, 2020 Feb 06; 198(2). PMID: 32016563
mTOR in Lung Neoplasms.
Ildiko Krencz, Anna Sebestyen, Andras Khoor.
Pathol Oncol Res, 2020 Feb 06; 26(1). PMID: 32016810
Review.
Trends and Patterns of Disparities in Burden of Lung Cancer in the United States, 1974-2015.
Yu Jie Zhong, Yi Feng Wen, +3 authors, Shuan Ying Yang.
Front Oncol, 2019 Jun 20; 9. PMID: 31214489    Free PMC article.
MYC-Driven Small-Cell Lung Cancer is Metabolically Distinct and Vulnerable to Arginine Depletion.
Milind D Chalishazar, Sarah J Wait, +18 authors, Trudy G Oliver.
Clin Cancer Res, 2019 Jun 06; 25(16). PMID: 31164374    Free PMC article.
Circular RNA cESRP1 sensitises small cell lung cancer cells to chemotherapy by sponging miR-93-5p to inhibit TGF-β signalling.
Weimei Huang, Yunchu Yang, +8 authors, Linlang Guo.
Cell Death Differ, 2019 Nov 16; 27(5). PMID: 31728016    Free PMC article.
Small Cell Lung Cancer Therapeutic Responses Through Fractal Measurements: From Radiology to Mitochondrial Biology.
Isa Mambetsariev, Tamara Mirzapoiazova, +7 authors, Ravi Salgia.
J Clin Med, 2019 Jul 19; 8(7). PMID: 31315252    Free PMC article.
Innate and Adaptive Immunity Linked to Recognition of Antigens Shared by Neural Crest-Derived Tumors.
Giuseppe Donato, Ivan Presta, +4 authors, Natalia Malara.
Cancers (Basel), 2020 Apr 05; 12(4). PMID: 32244473    Free PMC article.
Review.
Non-Coding RNAs in Lung Tumor Initiation and Progression.
Ruben Mercado Santos, Cerena Moreno, Wen Cai Zhang.
Int J Mol Sci, 2020 Apr 23; 21(8). PMID: 32316322    Free PMC article.
Review.
Targeted Inhibition of the E3 Ligase SCFSkp2/Cks1 Has Antitumor Activity in RB1-Deficient Human and Mouse Small-Cell Lung Cancer.
Hongling Zhao, Niloy J Iqbal, +7 authors, Liang Zhu.
Cancer Res, 2020 Apr 09; 80(11). PMID: 32265224    Free PMC article.
Prognostic value of neuron-specific enolase for small cell lung cancer: a systematic review and meta-analysis.
Zhoujunyi Tian, Chaoyang Liang, +5 authors, Guangliang Qiang.
World J Surg Oncol, 2020 Jun 01; 18(1). PMID: 32473655    Free PMC article.
Systematic Review.
Targeted Therapies and Biomarkers in Small Cell Lung Cancer.
Hirokazu Taniguchi, Triparna Sen, Charles M Rudin.
Front Oncol, 2020 Jun 09; 10. PMID: 32509576    Free PMC article.
Review.
Development and validation of a prognostic model of resectable small-cell lung cancer: a large population-based cohort study and external validation.
Yu Wang, Zhaofei Pang, +3 authors, Jiajun Du.
J Transl Med, 2020 Jun 17; 18(1). PMID: 32539859    Free PMC article.
Surgical Treatment of Spinal Cord Compression Caused by Metastatic Small Cell Lung Cancer: Ten Years of Experience in a Single Center.
Xin Gao, Kun Zhang, +7 authors, Jianru Xiao.
Cancer Manag Res, 2020 Jun 18; 12. PMID: 32547194    Free PMC article.
Epigenome-wide DNA methylation analysis of small cell lung cancer cell lines suggests potential chemotherapy targets.
Julia Krushkal, Thomas Silvers, +10 authors, Beverly A Teicher.
Clin Epigenetics, 2020 Jun 27; 12(1). PMID: 32586373    Free PMC article.
Modeling heterogeneous tumor growth dynamics and cell-cell interactions at single-cell and cell-population resolution.
Leonard A Harris, Samantha Beik, +2 authors, Alissa M Weaver.
Curr Opin Syst Biol, 2020 Jul 10; 17. PMID: 32642602    Free PMC article.
Targeting cancer stem cell pathways for cancer therapy.
Liqun Yang, Pengfei Shi, +8 authors, Hongjuan Cui.
Signal Transduct Target Ther, 2020 Apr 17; 5(1). PMID: 32296030    Free PMC article.
Review.
ASXL3 bridges BRD4 to BAP1 complex and governs enhancer activity in small cell lung cancer.
Aileen Patricia Szczepanski, Zibo Zhao, +3 authors, Lu Wang.
Genome Med, 2020 Jul 17; 12(1). PMID: 32669118    Free PMC article.
Different Originating Cells Underlie Intertumoral Heterogeneity in Lung Neuroendocrine Tumors.
Karine Pozo, Demetra P Kelenis, John D Minna, Jane E Johnson.
Cancer Discov, 2018 Oct 04; 8(10). PMID: 30279195    Free PMC article.
A Cereblon Modulator CC-885 Induces CRBN- and p97-Dependent PLK1 Degradation and Synergizes with Volasertib to Suppress Lung Cancer.
Lifeng Li, Wenhua Xue, +9 authors, Jie Zhao.
Mol Ther Oncolytics, 2020 Jul 31; 18. PMID: 32728610    Free PMC article.
Small cell lung cancer (SCLC) incidence and trends vary by gender, geography, age, and subcategory based on population and hospital cancer registries in Hebei, China (2008-2017).
Daojuan Li, Xiaoli Xu, +5 authors, Yutong He.
Thorac Cancer, 2020 Jun 27; 11(8). PMID: 32589361    Free PMC article.
Interferon-Induced Transmembrane Protein 1 (IFITM1) Promotes Distant Metastasis of Small Cell Lung Cancer.
Shuichi Sakamoto, Hiroyuki Inoue, +3 authors, Manabu Kawada.
Int J Mol Sci, 2020 Jul 17; 21(14). PMID: 32668617    Free PMC article.
[New Advances in the Treatment for Small Cell Lung Cancer].
Xiaoxia Cui, Peng Song, Li Zhang.
Zhongguo Fei Ai Za Zhi, 2019 Jun 15; 22(6). PMID: 31196369    Free PMC article.
Review.
[Predictive Value of Tumor Mutation Burden in Immunotherapy for Lung Cancer].
Huanlan Sa, Kewei Ma, Yong Gao, Deqiang Wang.
Zhongguo Fei Ai Za Zhi, 2019 Jun 15; 22(6). PMID: 31196372    Free PMC article.
Review.
Immunohistochemistry and Radiomic Features for Survival Prediction in Small Cell Lung Cancer.
Eleni Gkika, Matthias Benndorf, +13 authors, Gian Kayser.
Front Oncol, 2020 Sep 10; 10. PMID: 32903606    Free PMC article.
ASCL1-regulated DARPP-32 and t-DARPP stimulate small cell lung cancer growth and neuroendocrine tumour cell proliferation.
Sk Kayum Alam, Li Wang, +5 authors, Luke H Hoeppner.
Br J Cancer, 2020 Jun 06; 123(5). PMID: 32499571    Free PMC article.
Role of mTOR As an Essential Kinase in SCLC.
Jeffrey A Kern, Jihye Kim, +9 authors, Aik-Choon Tan.
J Thorac Oncol, 2020 Jul 01; 15(9). PMID: 32599072    Free PMC article.
Rho-kinase inhibition by Fasudil promotes tumor maturation and apoptosis in small-cell lung cancer.
Zitian Huo, Yinxia Su, +4 authors, Guoping Wang.
Am J Transl Res, 2020 Sep 12; 12(8). PMID: 32913511    Free PMC article.
[Clinical Development of Immunotherapy for Small Cell Lung Cancer].
Tao Yu, Diansheng Zhong.
Zhongguo Fei Ai Za Zhi, 2018 Dec 29; 21(12). PMID: 30591100    Free PMC article.
Review.
Arsenic trioxide inhibits the growth of cancer stem cells derived from small cell lung cancer by downregulating stem cell-maintenance factors and inducing apoptosis via the Hedgehog signaling blockade.
Ke-Jie Chang, Ji-Zhong Yin, +2 authors, Meng-Hang Yang.
Transl Lung Cancer Res, 2020 Sep 22; 9(4). PMID: 32953511    Free PMC article.
CD39: the potential target in small cell lung cancer.
Shanhao Chen, Shengyu Wu, +14 authors, Caicun Zhou.
Transl Lung Cancer Res, 2020 Sep 22; 9(4). PMID: 32953520    Free PMC article.
Paclitaxel for relapsed small-cell lung cancer patients with idiopathic interstitial pneumonias.
Atsuro Saijo, Masaki Hanibuchi, +4 authors, Yasuhiko Nishioka.
Mol Clin Oncol, 2019 Apr 11; 10(5). PMID: 30967948    Free PMC article.
Prognostic value of delta-like protein 3 combined with thyroid transcription factor-1 in small-cell lung cancer.
Li-Xu Yan, Yan-Hui Liu, +7 authors, Jiao He.
Oncol Lett, 2019 Aug 28; 18(3). PMID: 31452726    Free PMC article.
Exosomal miR-141 promotes tumor angiogenesis via KLF12 in small cell lung cancer.
Shuangshuang Mao, Zhiliang Lu, +9 authors, Jie He.
J Exp Clin Cancer Res, 2020 Sep 23; 39(1). PMID: 32958011    Free PMC article.
Autophagy inhibition enhances the inhibitory effects of ursolic acid on lung cancer cells.
Min Wang, Hong Yu, +5 authors, Guang-Biao Zhou.
Int J Mol Med, 2020 Sep 10; 46(5). PMID: 32901853    Free PMC article.
Nutrition, Bioenergetics, and Metabolic Syndrome.
Francesc Josep García-García, Anna Monistrol-Mula, Francesc Cardellach, Glòria Garrabou.
Nutrients, 2020 Sep 17; 12(9). PMID: 32933003    Free PMC article.
Review.
Emerging role of tumor cell plasticity in modifying therapeutic response.
Siyuan Qin, Jingwen Jiang, +4 authors, Weifeng He.
Signal Transduct Target Ther, 2020 Oct 09; 5(1). PMID: 33028808    Free PMC article.
Review.
The dual HDAC-PI3K inhibitor CUDC-907 displays single-agent activity and synergizes with PARP inhibitor olaparib in small cell lung cancer.
Liying Ma, Xing Bian, Wenchu Lin.
J Exp Clin Cancer Res, 2020 Oct 19; 39(1). PMID: 33069237    Free PMC article.
Comparison of First-Line Treatments for Patients With Extensive-Stage Small Cell Lung Cancer: A Systematic Review and Network Meta-analysis.
Ting Zhou, Zhonghan Zhang, +7 authors, Li Zhang.
JAMA Netw Open, 2020 Oct 20; 3(10). PMID: 33074323    Free PMC article.
Systematic Review.
Single-Dose Cisplatin Pre-Treatment Enhances Efficacy of ROBO1-Targeted Radioimmunotherapy.
Kentaro Fujiwara, Keitaro Koyama, +5 authors, Takao Hamakubo.
Int J Mol Sci, 2020 Oct 23; 21(20). PMID: 33086574    Free PMC article.
[Correlation between Pretreatment Serum Apolipoprotein Level and Prognosis of Small Cell Lung Cancer Patients].
Ya Dong, Haocheng Wang, +2 authors, Zhuang Yu.
Zhongguo Fei Ai Za Zhi, 2020 Oct 19; 23(10). PMID: 33070513    Free PMC article.
The MYC Paralog-PARP1 Axis as a Potential Therapeutic Target in MYC Paralog-Activated Small Cell Lung Cancer.
Xing Bian, Xiaolin Wang, +6 authors, Wenchu Lin.
Front Oncol, 2020 Nov 03; 10. PMID: 33134168    Free PMC article.
The prognostic implications of Notch1, Hes1, Ascl1, and DLL3 protein expression in SCLC patients receiving platinum-based chemotherapy.
Salomon Tendler, Lena Kanter, +3 authors, Luigi De Petris.
PLoS One, 2020 Oct 27; 15(10). PMID: 33104707    Free PMC article.
SCLC-CellMiner: A Resource for Small Cell Lung Cancer Cell Line Genomics and Pharmacology Based on Genomic Signatures.
Camille Tlemsani, Lorinc Pongor, +16 authors, Yves Pommier.
Cell Rep, 2020 Oct 22; 33(3). PMID: 33086069    Free PMC article.
Prognostic value of 18F-FDG PET/CT metabolic parameters in small cell lung cancer.
Eun Kyoung Choi, Minjae Park, +2 authors, Jin Kyoung Oh.
J Int Med Res, 2019 Dec 28; 48(4). PMID: 31880209    Free PMC article.
The prognostic value of pretreatment prognostic nutritional index in patients with small cell lung cancer and it's influencing factors: a meta-analysis of observational studies.
Ai-Min Jiang, Rui Zhao, +4 authors, Yu Yao.
J Thorac Dis, 2020 Nov 20; 12(10). PMID: 33209404    Free PMC article.
PARP inhibitors for small cell lung cancer and their potential for integration into current treatment approaches.
Ranya Barayan, Xiaozhuo Ran, Benjamin H Lok.
J Thorac Dis, 2020 Nov 20; 12(10). PMID: 33209463    Free PMC article.
Review.
What is the role of consolidative thoracic radiotherapy in the era of chemo-immunotherapy for extensive stage small cell lung cancer?
Kristin A Higgins, Ben J Slotman.
J Thorac Dis, 2020 Nov 20; 12(10). PMID: 33209469    Free PMC article.
Comprehensive genomic profile of Chinese lung cancer patients and mutation characteristics of individuals resistant to icotinib/gefitinib.
Yanhong Shang, Xiaofang Li, +11 authors, Lin Zhang.
Sci Rep, 2020 Nov 22; 10(1). PMID: 33219256    Free PMC article.
Integrated Immunohistochemical Study on Small-Cell Carcinoma of the Lung Focusing on Transcription and Co-Transcription Factors.
Younosuke Sato, Isamu Okamoto, +11 authors, Takaaki Ito.
Diagnostics (Basel), 2020 Nov 19; 10(11). PMID: 33202998    Free PMC article.
Tumor Mutational Burden and Efficacy of Nivolumab Monotherapy and in Combination with Ipilimumab in Small-Cell Lung Cancer.
Matthew D Hellmann, Margaret K Callahan, +13 authors, Scott J Antonia.
Cancer Cell, 2018 May 08; 33(5). PMID: 29731394    Free PMC article.
Highly Cited.
Knockdown of Ubiquitin Associated Protein 2-Like (UBAP2L) Inhibits Growth and Metastasis of Hepatocellular Carcinoma.
Qian Li, Wei Wang, +2 authors, Jie He.
Med Sci Monit, 2018 Oct 07; 24. PMID: 30291221    Free PMC article.
The role of immunotherapy in small cell lung cancer.
A Calles, G Aguado, C Sandoval, R Álvarez.
Clin Transl Oncol, 2019 Jan 15; 21(8). PMID: 30637710
Review.
Timing of treatment in small-cell lung cancer.
Shruti Bhandari, Danh Pham, +2 authors, Goetz Kloecker.
Med Oncol, 2019 Apr 27; 36(6). PMID: 31025131
Comparison of four DLL3 antibodies performance in high grade neuroendocrine lung tumor samples and cell cultures.
Luka Brcic, Christian Kuchler, +4 authors, Helmut Popper.
Diagn Pathol, 2019 May 22; 14(1). PMID: 31109352    Free PMC article.
The Influence of Systemic Inflammation Response Index on Survival Outcomes of Limited-Stage Small-Cell Lung Cancer Patients Treated with Concurrent Chemoradiotherapy.
Ahmet Kucuk, Emine Elif Ozkan, +4 authors, Erkan Topkan.
J Oncol, 2021 Jan 01; 2020. PMID: 33381177    Free PMC article.
Guanosine triphosphate links MYC-dependent metabolic and ribosome programs in small-cell lung cancer.
Fang Huang, Kenneth E Huffman, +25 authors, Ralph J DeBerardinis.
J Clin Invest, 2020 Oct 21; 131(1). PMID: 33079728    Free PMC article.
Genomic and pathological heterogeneity in clinically diagnosed small cell lung cancer in never/light smokers identifies therapeutically targetable alterations.
Atsuko Ogino, Jihyun Choi, +14 authors, Pasi A Jänne.
Mol Oncol, 2020 Mar 20; 15(1). PMID: 32191822    Free PMC article.
Neuroendocrine Lung Cancer Mouse Models: An Overview.
Corina Lorz, Marta Oteo, Mirentxu Santos.
Cancers (Basel), 2020 Dec 31; 13(1). PMID: 33375066    Free PMC article.
Review.
Low-dose apatinib monotherapy in advanced chemotherapy-refractory small cell lung cancer: a case series and literature review.
Ying-Ying Liu, Tao Chen, +4 authors, Da-Xiong Zeng.
J Int Med Res, 2019 Dec 19; 48(3). PMID: 31847652    Free PMC article.
Review.
Profilin 2 promotes growth, metastasis, and angiogenesis of small cell lung cancer through cancer-derived exosomes.
Qi Cao, Yihan Liu, +11 authors, Zhenwen Chen.
Aging (Albany NY), 2020 Nov 26; 12(24). PMID: 33234737    Free PMC article.
Mechanisms of small cell lung cancer metastasis.
Julie Ko, Monte M Winslow, Julien Sage.
EMBO Mol Med, 2020 Dec 10; 13(1). PMID: 33296145    Free PMC article.
Review.
Pre-radiotherapy lymphocyte count and platelet-to-lymphocyte ratio may improve survival prediction beyond clinical factors in limited stage small cell lung cancer: model development and validation.
Yishan Yu, Linlin Wang, +7 authors, Feng-Ming Spring Kong.
Transl Lung Cancer Res, 2021 Jan 26; 9(6). PMID: 33489795    Free PMC article.
Inflammation scores as prognostic biomarkers in small cell lung cancer: a systematic review and meta-analysis.
Anne Winther-Larsen, Ninna Aggerholm-Pedersen, Birgitte Sandfeld-Paulsen.
Syst Rev, 2021 Jan 30; 10(1). PMID: 33509254    Free PMC article.
Molecular genomic features associated with in vitro response of the NCI-60 cancer cell line panel to natural products.
Julia Krushkal, Simarjeet Negi, +8 authors, Barry R O'Keefe.
Mol Oncol, 2020 Nov 11; 15(2). PMID: 33169510    Free PMC article.
Prototypical oncogene family Myc defines unappreciated distinct lineage states of small cell lung cancer.
Ayushi S Patel, Seungyeul Yoo, +11 authors, Hideo Watanabe.
Sci Adv, 2021 Jan 31; 7(5). PMID: 33514539    Free PMC article.
Evaluation of diagnostic and predictive values of the serum VEGF-A level and systemic immune-inflammation index in small cell lung cancer.
Jing-Hao Yao, Yu Shao, +4 authors, Yan Yang.
J Cancer, 2021 Feb 04; 12(5). PMID: 33531980    Free PMC article.
LncRNA LINC01116 sponges miR-93-5p to promote cell invasion and migration in small cell lung cancer.
Wenzhou Liu, Feihai Liang, Guangyu Yang, Lei Xian.
BMC Pulm Med, 2021 Feb 05; 21(1). PMID: 33535997    Free PMC article.
Differential Expression of PD-L1 in Central and Peripheral and TTF1-Positive and -Negative Small-Cell Lung Cancer.
Shili Yu, Meng Jia, +2 authors, Hongwen Gao.
Front Med (Lausanne), 2021 Feb 16; 7. PMID: 33585516    Free PMC article.
Morphologic and molecular classification of lung neuroendocrine neoplasms.
Jasna Metovic, Marco Barella, +12 authors, Giuseppe Pelosi.
Virchows Arch, 2021 Jan 22; 478(1). PMID: 33474631    Free PMC article.
Review.
Long-term remission of small cell lung cancer after reactivation of tuberculosis following immune-checkpoint blockade: A case report.
Mattia Sirgiovanni, Clemens Hinterleitner, +4 authors, Martina Hinterleitner.
Thorac Cancer, 2021 Jan 19; 12(5). PMID: 33458956    Free PMC article.
Curative efficacy might be an early predictor of prognosis in patients with small cell lung cancer treated with 2 cycles of platinum-based first-line chemotherapy.
Kaibo Zhu, Minlin Jiang, +7 authors, Yayi He.
J Thorac Dis, 2021 Mar 16; 13(2). PMID: 33717593    Free PMC article.
Apatinib with etoposide capsules as a third- or further-line therapy for extensive-stage small cell lung cancer: an open-label, multicenter, single-arm phase II trial.
Zhen He, Hanqiong Zhou, +15 authors, Qiming Wang.
Transl Lung Cancer Res, 2021 Mar 16; 10(2). PMID: 33718030    Free PMC article.
Molecular profiles of small cell lung cancer subtypes: therapeutic implications.
Anna Schwendenwein, Zsolt Megyesfalvi, +17 authors, Balazs Dome.
Mol Ther Oncolytics, 2021 Mar 16; 20. PMID: 33718595    Free PMC article.
Review.
The landscape of small cell lung cancer metastases: Organ specificity and timing.
Zsolt Megyesfalvi, Bernadett Tallosy, +10 authors, Balazs Dome.
Thorac Cancer, 2021 Feb 04; 12(6). PMID: 33533174    Free PMC article.
Cell-autonomous immune gene expression is repressed in pulmonary neuroendocrine cells and small cell lung cancer.
Ling Cai, Hongyu Liu, +27 authors, Adi F Gazdar.
Commun Biol, 2021 Mar 23; 4(1). PMID: 33750914    Free PMC article.
Topological signatures in regulatory network enable phenotypic heterogeneity in small cell lung cancer.
Lakshya Chauhan, Uday Ram, Kishore Hari, Mohit Kumar Jolly.
Elife, 2021 Mar 18; 10. PMID: 33729159    Free PMC article.
Novel Cytotoxic Chemotherapies in Small Cell Lung Carcinoma.
Diego Cortinovis, Paolo Bidoli, +6 authors, Alessandro Morabito.
Cancers (Basel), 2021 Apr 04; 13(5). PMID: 33800236    Free PMC article.
Review.
Metabolic Health Together with a Lipid Genetic Risk Score Predicts Survival of Small Cell Lung Cancer Patients.
Lara P Fernández, María Merino, +6 authors, Ana Ramírez de Molina.
Cancers (Basel), 2021 Apr 04; 13(5). PMID: 33807668    Free PMC article.
High pretreatment D-dimer level is an independent unfavorable prognostic factor of small cell lung cancer: A systematic review and meta-analysis.
Han-Yu Deng, Xing-Sheng Ma, +3 authors, Xiao-Ming Qiu.
Medicine (Baltimore), 2021 Apr 14; 100(15). PMID: 33847650    Free PMC article.
Systematic Review.
Algorithm using Neuron-Specific Enolase and Pro-Gastrin-Releasing Peptide to Increase the Diagnostic Accuracy for Small Cell Lung Cancer.
Haeyoung Lee, Sung Dal Park, +4 authors, Hyunyong Hwang.
Ann Lab Med, 2020 Dec 12; 41(3). PMID: 33303722    Free PMC article.
Small Cell Lung Cancer: State of the Art of the Molecular and Genetic Landscape and Novel Perspective.
Valeria Denninghoff, Alessandro Russo, +5 authors, Christian Rolfo.
Cancers (Basel), 2021 May 01; 13(7). PMID: 33917282    Free PMC article.
Review.
Molecular Pathology of Pulmonary Large Cell Neuroendocrine Carcinoma: Novel Concepts and Treatments.
Masayo Yoshimura, Kurumi Seki, Andrey Bychkov, Junya Fukuoka.
Front Oncol, 2021 May 11; 11. PMID: 33968782    Free PMC article.
Review.
Identifying Genomic Alterations in Small Cell Lung Cancer Using the Liquid Biopsy of Bronchial Washing Fluid.
Jinfang Zhai, Songyan Han, +15 authors, Weihua Yang.
Front Oncol, 2021 May 15; 11. PMID: 33987084    Free PMC article.
pN1 but not pN0/N2 predicts survival benefits of prophylactic cranial irradiation in small-cell lung cancer patients after surgery.
Haitang Yang, Mohammad Faisal Al-Hurani, +4 authors, Feng Yao.
Ann Transl Med, 2021 May 15; 9(7). PMID: 33987260    Free PMC article.
Clinical significance of the cachexia index in patients with small cell lung cancer.
Se-Il Go, Mi Jung Park, Gyeong-Won Lee.
BMC Cancer, 2021 May 19; 21(1). PMID: 34001060    Free PMC article.
Distinct patterns of somatic genomic alterations and mutational signatures in central and peripheral-type small-cell lung cancer.
Lei Wang, Jing Wang, +4 authors, Caicun Zhou.
Transl Lung Cancer Res, 2021 May 21; 10(4). PMID: 34012790    Free PMC article.
Patient with respiratory distress, facial oedema and refractory hypokalaemia.
Udara Dilrukshi Senarathne, Bolonghoge Krishantha Trixy Priyankara Dayanath, Ramani Punchihewa, Bandu Gunasena.
BMJ Case Rep, 2021 May 09; 14(5). PMID: 33962921    Free PMC article.