Review
. 2017 Nov; 15(2):81-94.
doi: 10.1038/nrclinonc.2017.166.

Tumour heterogeneity and resistance to cancer therapies

Ibiayi Dagogo-Jack 1 Alice T Shaw 1 
Affiliations
  • PMID: 29115304
  •     125 References
  •     404 citations

Abstract

Cancer is a dynamic disease. During the course of disease, cancers generally become more heterogeneous. As a result of this heterogeneity, the bulk tumour might include a diverse collection of cells harbouring distinct molecular signatures with differential levels of sensitivity to treatment. This heterogeneity might result in a non-uniform distribution of genetically distinct tumour-cell subpopulations across and within disease sites (spatial heterogeneity) or temporal variations in the molecular makeup of cancer cells (temporal heterogeneity). Heterogeneity provides the fuel for resistance; therefore, an accurate assessment of tumour heterogeneity is essential for the development of effective therapies. Multiregion sequencing, single-cell sequencing, analysis of autopsy samples, and longitudinal analysis of liquid biopsy samples are all emerging technologies with considerable potential to dissect the complex clonal architecture of cancers. In this Review, we discuss the driving forces behind intratumoural heterogeneity and the current approaches used to combat this heterogeneity and its consequences. We also explore how clinical assessments of tumour heterogeneity might facilitate the development of more-effective personalized therapies.

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Katja Harbst, Martin Lauss, +12 authors, Göran Jönsson.
Cancer Res, 2016 May 25; 76(16). PMID: 27216186
Heterogeneity in resistance mechanisms causes shorter duration of epidermal growth factor receptor kinase inhibitor treatment in lung cancer.
Kenichi Suda, Isao Murakami, +5 authors, Tetsuya Mitsudomi.
Lung Cancer, 2015 Dec 30; 91. PMID: 26711932
Tumour cell heterogeneity maintained by cooperating subclones in Wnt-driven mammary cancers.
Allison S Cleary, Travis L Leonard, Shelley A Gestl, Edward J Gunther.
Nature, 2014 Apr 04; 508(7494). PMID: 24695311    Free PMC article.
Highly Cited.
RB loss in resistant EGFR mutant lung adenocarcinomas that transform to small-cell lung cancer.
Matthew J Niederst, Lecia V Sequist, +24 authors, Jeffrey A Engelman.
Nat Commun, 2015 Mar 12; 6. PMID: 25758528    Free PMC article.
Highly Cited.
Divergent modes of clonal spread and intraperitoneal mixing in high-grade serous ovarian cancer.
Andrew McPherson, Andrew Roth, +31 authors, Sohrab P Shah.
Nat Genet, 2016 May 18; 48(7). PMID: 27182968
Highly Cited.
Acquired RAS or EGFR mutations and duration of response to EGFR blockade in colorectal cancer.
Beth O Van Emburgh, Sabrina Arena, +19 authors, Alberto Bardelli.
Nat Commun, 2016 Dec 09; 7. PMID: 27929064    Free PMC article.
Highly Cited.
A framework for understanding and targeting residual disease in oncogene-driven solid cancers.
Trever G Bivona, Robert C Doebele.
Nat Med, 2016 May 07; 22(5). PMID: 27149220    Free PMC article.
Highly Cited.
Evidence for APOBEC3B mutagenesis in multiple human cancers.
Michael B Burns, Nuri A Temiz, Reuben S Harris.
Nat Genet, 2013 Jul 16; 45(9). PMID: 23852168    Free PMC article.
Highly Cited.
Clinical utility of circulating DNA analysis for rapid detection of actionable mutations to select metastatic colorectal patients for anti-EGFR treatment.
A R Thierry, S El Messaoudi, +17 authors, M Ychou.
Ann Oncol, 2017 Sep 16; 28(9). PMID: 28911069
Spatial and temporal diversity in genomic instability processes defines lung cancer evolution.
Elza C de Bruin, Nicholas McGranahan, +40 authors, Charles Swanton.
Science, 2014 Oct 11; 346(6206). PMID: 25301630    Free PMC article.
Highly Cited.
Combined EGFR/MEK Inhibition Prevents the Emergence of Resistance in EGFR-Mutant Lung Cancer.
Erin M Tricker, Chunxiao Xu, +8 authors, Pasi A Jänne.
Cancer Discov, 2015 Jun 04; 5(9). PMID: 26036643    Free PMC article.
Highly Cited.
Dynamic clonal equilibrium and predetermined cancer risk in Barrett's oesophagus.
Pierre Martinez, Margriet R Timmer, +17 authors, Kausilia K Krishnadath.
Nat Commun, 2016 Aug 20; 7. PMID: 27538785    Free PMC article.
Noninvasive identification and monitoring of cancer mutations by targeted deep sequencing of plasma DNA.
Tim Forshew, Muhammed Murtaza, +12 authors, Nitzan Rosenfeld.
Sci Transl Med, 2012 Jun 01; 4(136). PMID: 22649089
Highly Cited.
The life history of 21 breast cancers.
Serena Nik-Zainal, Peter Van Loo, +47 authors, Breast Cancer Working Group of the International Cancer Genome Consortium.
Cell, 2012 May 23; 149(5). PMID: 22608083    Free PMC article.
Highly Cited.
NF-κB-activating complex engaged in response to EGFR oncogene inhibition drives tumor cell survival and residual disease in lung cancer.
Collin M Blakely, Evangelos Pazarentzos, +17 authors, Trever G Bivona.
Cell Rep, 2015 Apr 07; 11(1). PMID: 25843712    Free PMC article.
Highly Cited.
Detection and clinical significance of intratumoral EGFR mutational heterogeneity in Chinese patients with advanced non-small cell lung cancer.
Hua Bai, Zhijie Wang, +8 authors, Jie Wang.
PLoS One, 2013 Feb 19; 8(2). PMID: 23418425    Free PMC article.
Co-activation of STAT3 and YES-Associated Protein 1 (YAP1) Pathway in EGFR-Mutant NSCLC.
Imane Chaib, Niki Karachaliou, +38 authors, Rafael Rosell.
J Natl Cancer Inst, 2017 Apr 05; 109(9). PMID: 28376152    Free PMC article.
Highly Cited.
Distant metastasis occurs late during the genetic evolution of pancreatic cancer.
Shinichi Yachida, Siân Jones, +11 authors, Christine A Iacobuzio-Donahue.
Nature, 2010 Oct 29; 467(7319). PMID: 20981102    Free PMC article.
Highly Cited.
The Allelic Context of the C797S Mutation Acquired upon Treatment with Third-Generation EGFR Inhibitors Impacts Sensitivity to Subsequent Treatment Strategies.
Matthew J Niederst, Haichuan Hu, +5 authors, Jeffrey A Engelman.
Clin Cancer Res, 2015 May 13; 21(17). PMID: 25964297    Free PMC article.
Highly Cited.
Genomic architecture and evolution of clear cell renal cell carcinomas defined by multiregion sequencing.
Marco Gerlinger, Stuart Horswell, +22 authors, Charles Swanton.
Nat Genet, 2014 Feb 04; 46(3). PMID: 24487277    Free PMC article.
Highly Cited.
Clonal evolution in relapsed acute myeloid leukaemia revealed by whole-genome sequencing.
Li Ding, Timothy J Ley, +36 authors, John F DiPersio.
Nature, 2012 Jan 13; 481(7382). PMID: 22237025    Free PMC article.
Highly Cited.
Intratumoral heterogeneity of Notch1 expression in small cell lung cancer.
Takaaki Ito.
J Thorac Dis, 2018 May 01; 10(3). PMID: 29707277    Free PMC article.
Targeted Tumor Therapy Remixed-An Update on the Use of Small-Molecule Drugs in Combination Therapies.
Martina V Gatzka.
Cancers (Basel), 2018 May 26; 10(6). PMID: 29794999    Free PMC article.
Review.
PanDrugs: a novel method to prioritize anticancer drug treatments according to individual genomic data.
Elena Piñeiro-Yáñez, Miguel Reboiro-Jato, +11 authors, Fátima Al-Shahrour.
Genome Med, 2018 Jun 01; 10(1). PMID: 29848362    Free PMC article.
Molecular imaging and molecular diagnostics: two sides of the same coin?
Marcus Hacker, Gregor Hoermann, Lukas Kenner.
Eur J Nucl Med Mol Imaging, 2018 Jun 04; 45(10). PMID: 29860534
Current understanding of reovirus oncolysis mechanisms.
Matthew B Phillips, Johnasha D Stuart, +3 authors, Karl W Boehme.
Oncolytic Virother, 2018 Jun 27; 7. PMID: 29942799    Free PMC article.
Review.
Epithelial-to-mesenchymal transition in cancer: complexity and opportunities.
Yun Zhang, Robert A Weinberg.
Front Med, 2018 Jul 26; 12(4). PMID: 30043221    Free PMC article.
Highly Cited. Review.
Global Stabilization of Boolean Networks to Control the Heterogeneity of Cellular Responses.
Jung-Min Yang, Chun-Kyung Lee, Kwang-Hyun Cho.
Front Physiol, 2018 Aug 04; 9. PMID: 30072906    Free PMC article.
Genetic and epigenetic alterations of colorectal cancer.
Sung Noh Hong.
Intest Res, 2018 Aug 10; 16(3). PMID: 30090031    Free PMC article.
Review.
Viral tumor antigen expression is no longer required in radiation-resistant subpopulation of JCV induced mouse medulloblastoma cells.
Martina Donadoni, Rahsan Sariyer, +2 authors, Ilker Kudret Sariyer.
Genes Cancer, 2018 Aug 16; 9(3-4). PMID: 30108683    Free PMC article.
Aberrant Regulation of mRNA m⁶A Modification in Cancer Development.
Junyun Luo, Hui Liu, +2 authors, Zhaoyong Li.
Int J Mol Sci, 2018 Aug 29; 19(9). PMID: 30149601    Free PMC article.
Review.
Plasticity of Type I Interferon-Mediated Responses in Cancer Therapy: From Anti-tumor Immunity to Resistance.
Megha Budhwani, Roberta Mazzieri, Riccardo Dolcetti.
Front Oncol, 2018 Sep 07; 8. PMID: 30186768    Free PMC article.
Review.
Retinoblastoma Intrinsically Regulates Niche Cell Quiescence, Identity, and Niche Number in the Adult Drosophila Testis.
Leah J Greenspan, Erika L Matunis.
Cell Rep, 2018 Sep 27; 24(13). PMID: 30257208    Free PMC article.
Inhibition of glioblastoma cell proliferation, invasion, and mechanism of action of a novel hydroxamic acid hybrid molecule.
Issan Zhang, Maja Beus, +5 authors, Dusica Maysinger.
Cell Death Discov, 2018 Oct 12; 4. PMID: 30302275    Free PMC article.
Radiomics and liquid biopsy in oncology: the holons of systems medicine.
Emanuele Neri, Marzia Del Re, +4 authors, Romano Danesi.
Insights Imaging, 2018 Nov 16; 9(6). PMID: 30430428    Free PMC article.
Review.
RollFISH achieves robust quantification of single-molecule RNA biomarkers in paraffin-embedded tumor tissue samples.
Chenglin Wu, Michele Simonetti, +8 authors, Mats Nilsson.
Commun Biol, 2018 Dec 05; 1. PMID: 30511022    Free PMC article.
The Combination of Omega-3 Stearidonic Acid and Docetaxel Enhances Cell Death over Docetaxel Alone in Human Prostate Cancer Cells.
Mahmoud Mansour, Sabrina van Ginkel, +6 authors, Edward Morrison.
J Cancer, 2018 Dec 07; 9(23). PMID: 30519360    Free PMC article.
Isolation of circulating tumor cells in non-small-cell-lung-cancer patients using a multi-flow microfluidic channel.
Jian Zhou, Arutha Kulasinghe, +3 authors, Ian Papautsky.
Microsyst Nanoeng, 2019 May 07; 5. PMID: 31057935    Free PMC article.
Highly Cited.
The Novel Oncolytic Compound LTX-401 Induces Antitumor Immune Responses in Experimental Hepatocellular Carcinoma.
Brynjar Mauseth, Ketil André Camilio, +4 authors, Pål-Dag Line.
Mol Ther Oncolytics, 2019 Jun 19; 14. PMID: 31211244    Free PMC article.
Integrated multiomic analysis reveals comprehensive tumour heterogeneity and novel immunophenotypic classification in hepatocellular carcinomas.
Qi Zhang, Yu Lou, +22 authors, Xueli Bai.
Gut, 2019 Jun 23; 68(11). PMID: 31227589    Free PMC article.
Highly Cited.
Genomics-Guided Immunotherapy for Precision Medicine in Cancer.
Shradha Mukherjee.
Cancer Biother Radiopharm, 2019 Jul 18; 34(8). PMID: 31314580    Free PMC article.
Review.
Exploring Tumor Heterogeneity Using PET Imaging: The Big Picture.
Clément Bailly, Caroline Bodet-Milin, +7 authors, Thomas Carlier.
Cancers (Basel), 2019 Sep 05; 11(9). PMID: 31480470    Free PMC article.
Review.
In Silico Drug Prescription for Targeting Cancer Patient Heterogeneity and Prediction of Clinical Outcome.
Elena Piñeiro-Yáñez, María José Jiménez-Santos, Gonzalo Gómez-López, Fátima Al-Shahrour.
Cancers (Basel), 2019 Sep 22; 11(9). PMID: 31540260    Free PMC article.
Cytogenetics and Cytogenomics Evaluation in Cancer.
Ilda Patrícia Ribeiro, Joana Barbosa Melo, Isabel Marques Carreira.
Int J Mol Sci, 2019 Sep 25; 20(19). PMID: 31547595    Free PMC article.
Review.
Addressing Patient Specificity in the Engineering of Tumor Models.
Laura J Bray, Dietmar W Hutmacher, Nathalie Bock.
Front Bioeng Biotechnol, 2019 Oct 02; 7. PMID: 31572718    Free PMC article.
Review.
Epigenetic Mechanisms of Escape from BRAF Oncogene Dependency.
Mehwish Khaliq, Mohammad Fallahi-Sichani.
Cancers (Basel), 2019 Oct 05; 11(10). PMID: 31581557    Free PMC article.
Review.
Clinical Practice Use of Liquid Biopsy to Identify RAS/BRAF Mutations in Patients with Metastatic Colorectal Cancer (mCRC): A Single Institution Experience.
Pietro Paolo Vitiello, Vincenzo De Falco, +23 authors, Erika Martinelli.
Cancers (Basel), 2019 Oct 11; 11(10). PMID: 31597339    Free PMC article.
Targeting cancer stem cells in squamous cell carcinoma.
Demeng Chen, Cun-Yu Wang.
Precis Clin Med, 2019 Oct 11; 2(3). PMID: 31598386    Free PMC article.
Review.
The Mutational Landscape of Pancreatic and Liver Cancers, as Represented by Circulating Tumor DNA.
Alistair Rice, Armando Del Rio Hernandez.
Front Oncol, 2019 Oct 15; 9. PMID: 31608239    Free PMC article.
Review.
The Metabolic Profile of Tumor and Virally Infected Cells Shapes Their Microenvironment Counteracting T Cell Immunity.
Isabelle Magalhaes, Ohad Yogev, Jonas Mattsson, Anna Schurich.
Front Immunol, 2019 Oct 23; 10. PMID: 31636636    Free PMC article.
Review.
Genome landscapes of rectal cancer before and after preoperative chemoradiotherapy.
Jie Yang, Yuan Lin, +13 authors, Dongxin Lin.
Theranostics, 2019 Oct 30; 9(23). PMID: 31660073    Free PMC article.
Tumor acidity activated triphenylphosphonium-based mitochondrial targeting nanocarriers for overcoming drug resistance of cancer therapy.
Hui Yu, Jia-Mi Li, +6 authors, Shi-Wen Huang.
Theranostics, 2019 Oct 30; 9(23). PMID: 31660085    Free PMC article.
Single cell analysis to dissect molecular heterogeneity and disease evolution in metastatic melanoma.
Luigi Fattore, Ciro Francesco Ruggiero, +2 authors, Gennaro Ciliberto.
Cell Death Dis, 2019 Nov 02; 10(11). PMID: 31672982    Free PMC article.
Review.
Molecular harvesting with electroporation for tissue profiling.
Alexander Golberg, Julia Sheviryov, +2 authors, Zohar Yakhini.
Sci Rep, 2019 Nov 02; 9(1). PMID: 31673038    Free PMC article.
Assessing reliability of intra-tumor heterogeneity estimates from single sample whole exome sequencing data.
Judith Abécassis, Anne-Sophie Hamy, +4 authors, Jean-Philippe Vert.
PLoS One, 2019 Nov 08; 14(11). PMID: 31697689    Free PMC article.
Biomimetic Nanoparticle Vaccines for Cancer Therapy.
Ashley V Kroll, Yao Jiang, +3 authors, Liangfang Zhang.
Adv Biosyst, 2019 Nov 16; 3(1). PMID: 31728404    Free PMC article.
Association of metabolic and genetic heterogeneity in head and neck squamous cell carcinoma with prognostic implications: integration of FDG PET and genomic analysis.
Jinyeong Choi, Jeong-An Gim, +4 authors, Hyung-Jun Im.
EJNMMI Res, 2019 Nov 23; 9(1). PMID: 31754877    Free PMC article.
Spa-RQ: an Image Analysis Tool to Visualise and Quantify Spatial Phenotypes Applied to Non-Small Cell Lung Cancer.
Jie Bao, Margarita Walliander, +7 authors, Emmy W Verschuren.
Sci Rep, 2019 Nov 28; 9(1). PMID: 31772293    Free PMC article.
Highly versatile cancer photoimmunotherapy using photosensitizer-conjugated avidin and biotin-conjugated targeting antibodies.
Naoto Shirasu, Hirotomo Shibaguchi, +2 authors, Shin'ichiro Yasunaga.
Cancer Cell Int, 2019 Dec 04; 19. PMID: 31787847    Free PMC article.
The inhibitory effects of cisplatin-radiation combination treatment on malignant osteosarcoma MG-63 cells and BRCA1-p53 pathways are more efficient than single treatments.
Hong-Bin Sun, He-Yuan Wang, +5 authors, Le-Ning Zhang.
Oncol Lett, 2019 Dec 07; 18(6). PMID: 31807162    Free PMC article.
Clinical correlates of blood-derived circulating tumor DNA in pancreatic cancer.
Hitendra Patel, Ryosuke Okamura, +5 authors, Razelle Kurzrock.
J Hematol Oncol, 2019 Dec 06; 12(1). PMID: 31801585    Free PMC article.
Unleashing The Potential Of Multiple-Targeted Therapies In Hepatobiliary Cancers: Two Cases, Cocktail Therapy With Nine Molecular Targeted Agents And Long-Lasting Survival.
Jianzhen Lin, Xiaobo Yang, Yuan Xie, Haitao Zhao.
Onco Targets Ther, 2019 Dec 11; 12. PMID: 31819490    Free PMC article.
Biomimetic Nanotechnology toward Personalized Vaccines.
Jiarong Zhou, Ashley V Kroll, +2 authors, Liangfang Zhang.
Adv Mater, 2019 Jun 18; 32(13). PMID: 31206841    Free PMC article.
Review.
[Liquid biopsy in colorectal cancer : An overview of ctDNA analysis in tumour diagnostics].
A Haupts, W Roth, N Hartmann.
Pathologe, 2019 Dec 05; 40(Suppl 3). PMID: 31797045
Review.
Expanding anaplastic lymphoma kinase therapeutic indication to early stage non-small cell lung cancer.
Fabrizio Tabbò, Silvia Novello.
Transl Lung Cancer Res, 2019 Dec 21; 8(Suppl 3). PMID: 31857952    Free PMC article.
Review.
In Vitro Assessment of Cytokine Expression Profile of MCF-7 Cells in Response to hWJ-MSCs Secretome.
Mansoureh Mirabdollahi, Shaghayegh Haghjooy Javanmard, Hojjat Sadeghi-Aliabadi.
Adv Pharm Bull, 2019 Dec 21; 9(4). PMID: 31857970    Free PMC article.
Molecular Mechanisms Underlying Autophagy-Mediated Treatment Resistance in Cancer.
Cally J Ho, Sharon M Gorski.
Cancers (Basel), 2019 Nov 14; 11(11). PMID: 31717997    Free PMC article.
Review.
Development of Targeted Alpha Particle Therapy for Solid Tumors.
Narges K Tafreshi, Michael L Doligalski, +8 authors, David L Morse.
Molecules, 2019 Nov 30; 24(23). PMID: 31779154    Free PMC article.
Review.
Spatio-temporal aspects of the interplay of cancer and the immune system.
Vladimir P Zhdanov.
J Biol Phys, 2019 Nov 28; 45(4). PMID: 31773382    Free PMC article.
Gain-of-Function Mutations: An Emerging Advantage for Cancer Biology.
Yongsheng Li, Yunpeng Zhang, +2 authors, Juan Xu.
Trends Biochem Sci, 2019 May 03; 44(8). PMID: 31047772    Free PMC article.
Review.
CD9 identifies pancreatic cancer stem cells and modulates glutamine metabolism to fuel tumour growth.
Victoria M-Y Wang, Rute M M Ferreira, +11 authors, Axel Behrens.
Nat Cell Biol, 2019 Nov 07; 21(11). PMID: 31685994    Free PMC article.
Current and Future Treatment Strategies for Rhabdomyosarcoma.
Celine Chen, Heathcliff Dorado Garcia, Monika Scheer, Anton G Henssen.
Front Oncol, 2020 Jan 11; 9. PMID: 31921698    Free PMC article.
Review.
Pyruvate Kinase M2: a Metabolic Bug in Re-Wiring the Tumor Microenvironment.
Mohd Rihan, Lakshmi Vineela Nalla, +3 authors, Amit Khairnar.
Cancer Microenviron, 2019 Jun 12; 12(2-3). PMID: 31183810    Free PMC article.
Review.
EPR-mediated tumor targeting using ultrasmall-hybrid nanoparticles: From animal to human with theranostic AGuIX nanoparticles.
Guillaume Bort, François Lux, +3 authors, Olivier Tillement.
Theranostics, 2020 Jan 16; 10(3). PMID: 31938067    Free PMC article.
Review.
Establishment and validation of a nomogram with intratumoral heterogeneity derived from 18F-FDG PET/CT for predicting individual conditional risk of 5-year recurrence before initial treatment of nasopharyngeal carcinoma.
Bingxin Gu, Jianping Zhang, +4 authors, Zhongyi Yang.
BMC Cancer, 2020 Jan 17; 20(1). PMID: 31941465    Free PMC article.
Development and application of two novel monoclonal antibodies against overexpressed CD26 and integrin α3 in human pancreatic cancer.
Gustavo A Arias-Pinilla, Angus G Dalgleish, +3 authors, Helmout Modjtahedi.
Sci Rep, 2020 Jan 19; 10(1). PMID: 31953437    Free PMC article.
A novel role of tumor suppressor ZMYND8 in inducing differentiation of breast cancer cells through its dual-histone binding function.
Shravanti Mukherjee, Sabyasachi Sen, +6 authors, Chandrima DAS.
J Biosci, 2020 Jan 23; 45. PMID: 31965980
2-Amino-2,3-dihydro-1H-indene-5-carboxamide-Based Discoidin Domain Receptor 1 (DDR1) Inhibitors: Design, Synthesis, and in Vivo Antipancreatic Cancer Efficacy.
Dongsheng Zhu, Huocong Huang, +10 authors, Xiaoyun Lu.
J Med Chem, 2019 Jul 17; 62(16). PMID: 31310125    Free PMC article.
Role of Complex Networks for Integrating Medical Images and Radiomic Features of Intracranial Ependymoma Patients in Response to Proton Radiotherapy.
Marco Dominietto, Alessia Pica, +3 authors, Enrico Capobianco.
Front Med (Lausanne), 2020 Feb 06; 6. PMID: 32010703    Free PMC article.
How to Make Anticancer Drugs Cross the Blood-Brain Barrier to Treat Brain Metastases.
Eurydice Angeli, Thuy T Nguyen, Anne Janin, Guilhem Bousquet.
Int J Mol Sci, 2019 Dec 22; 21(1). PMID: 31861465    Free PMC article.
Review.
Recent insights into apoptosis and toxic autophagy: The roles of MDA-7/IL-24, a multidimensional anti-cancer therapeutic.
Luni Emdad, Praveen Bhoopathi, +5 authors, Paul B Fisher.
Semin Cancer Biol, 2019 Jul 30; 66. PMID: 31356866    Free PMC article.
Review.
Spatial heterogeneity of nanomedicine investigated by multiscale imaging of the drug, the nanoparticle and the tumour environment.
Josanne Sophia de Maar, Alexandros Marios Sofias, +4 authors, Roel Deckers.
Theranostics, 2020 Feb 12; 10(4). PMID: 32042343    Free PMC article.
Review.
The Progress of Multi-Omics Technologies: Determining Function in Lactic Acid Bacteria Using a Systems Level Approach.
Shane Thomas O'Donnell, R Paul Ross, Catherine Stanton.
Front Microbiol, 2020 Feb 13; 10. PMID: 32047482    Free PMC article.
Review.
RefDNN: a reference drug based neural network for more accurate prediction of anticancer drug resistance.
Jonghwan Choi, Sanghyun Park, Jaegyoon Ahn.
Sci Rep, 2020 Feb 07; 10(1). PMID: 32024872    Free PMC article.
Imaging Phenotypes of Breast Cancer Heterogeneity in Preoperative Breast Dynamic Contrast Enhanced Magnetic Resonance Imaging (DCE-MRI) Scans Predict 10-Year Recurrence.
Rhea D Chitalia, Jennifer Rowland, +7 authors, Despina Kontos.
Clin Cancer Res, 2019 Nov 17; 26(4). PMID: 31732521    Free PMC article.
Post-mortem Plasma Cell-Free DNA Sequencing: Proof-of-Concept Study for the "Liquid Autopsy".
Erina Takai, Daichi Maeda, +17 authors, Akiteru Goto.
Sci Rep, 2020 Feb 09; 10(1). PMID: 32034265    Free PMC article.
Single-Cell Intravital Microscopy of Trastuzumab Quantifies Heterogeneous in vivo Kinetics.
Ran Li, Adel Attari, +3 authors, Miles A Miller.
Cytometry A, 2019 Aug 20; 97(5). PMID: 31423731    Free PMC article.
Blockade of TLR4 using TAK-242 (resatorvid) enhances anti-cancer effects of chemotherapeutic agents: a novel synergistic approach for breast and ovarian cancers.
Bahareh Kashani, Zahra Zandi, +3 authors, Seyed H Ghaffari.
Immunol Res, 2020 Feb 07; 67(6). PMID: 32026322
Clinical implications of intratumor heterogeneity: challenges and opportunities.
Santiago Ramón Y Cajal, Marta Sesé, +5 authors, Josep Castellví.
J Mol Med (Berl), 2020 Jan 24; 98(2). PMID: 31970428    Free PMC article.
Review.
Polytherapy and Targeted Cancer Drug Resistance.
Nilanjana Chatterjee, Trever G Bivona.
Trends Cancer, 2019 Mar 23; 5(3). PMID: 30898264    Free PMC article.
Review.
Cytoskeletal Proteins in Cancer and Intracellular Stress: A Therapeutic Perspective.
Mei Shan Ong, Shuo Deng, +7 authors, Celestial T Yap.
Cancers (Basel), 2020 Jan 23; 12(1). PMID: 31963677    Free PMC article.
Review.
Volumetric stimulated Raman scattering imaging of cleared tissues towards three-dimensional chemical histopathology.
Junjie Li, Peng Lin, Yuying Tan, Ji-Xin Cheng.
Biomed Opt Express, 2019 Aug 28; 10(8). PMID: 31453014    Free PMC article.
Can PD-L1 expression evaluated by biopsy sample accurately reflect its expression in the whole tumour in gastric cancer?
Kohei Yamashita, Masaaki Iwatsuki, +12 authors, Hideo Baba.
Br J Cancer, 2019 Jul 10; 121(3). PMID: 31285589    Free PMC article.
Power and pitfalls of computational methods for inferring clone phylogenies and mutation orders from bulk sequencing data.
Sayaka Miura, Tracy Vu, +4 authors, Sudhir Kumar.
Sci Rep, 2020 Feb 28; 10(1). PMID: 32103044    Free PMC article.
Prediction of Drug Efficacy in Colon Cancer Preclinical Models Using a Novel Ranking Method of Gene Expression.
Justine Fritz, Olivier Lefebvre, +2 authors, Dominique Bagnard.
Cancers (Basel), 2020 Jan 16; 12(1). PMID: 31936310    Free PMC article.
From the Clinic to the Bench and Back Again in One Dog Year: How a Cross-Species Pipeline to Identify New Treatments for Sarcoma Illuminates the Path Forward in Precision Medicine.
Sneha R Rao, Jason A Somarelli, +13 authors, William C Eward.
Front Oncol, 2020 Mar 03; 10. PMID: 32117764    Free PMC article.
Stochastic modeling of phenotypic switching and chemoresistance in cancer cell populations.
Niraj Kumar, Gwendolyn M Cramer, +3 authors, Rahul V Kulkarni.
Sci Rep, 2019 Jul 28; 9(1). PMID: 31350465    Free PMC article.
Increased glucocorticoid receptor activity and proliferation in metastatic colon cancer.
Dan Tian, Miao Tian, Gang Han, Jin-Long Li.
Sci Rep, 2019 Aug 04; 9(1). PMID: 31375708    Free PMC article.
Applications of CRISPR-Cas Enzymes in Cancer Therapeutics and Detection.
Chun-Hao Huang, Ko-Chuan Lee, Jennifer A Doudna.
Trends Cancer, 2018 Jun 26; 4(7). PMID: 29937048    Free PMC article.
Review.
PhysiBoSS: a multi-scale agent-based modelling framework integrating physical dimension and cell signalling.
Gaelle Letort, Arnau Montagud, +5 authors, Laurence Calzone.
Bioinformatics, 2018 Sep 01; 35(7). PMID: 30169736    Free PMC article.
Comparing the effects of different cell death programs in tumor progression and immunotherapy.
Michelle N Messmer, Annelise G Snyder, Andrew Oberst.
Cell Death Differ, 2018 Oct 21; 26(1). PMID: 30341424    Free PMC article.
Review.
Epitranscriptomic Signatures in lncRNAs and Their Possible Roles in Cancer.
Sorina Dinescu, Simona Ignat, +3 authors, Marieta Costache.
Genes (Basel), 2019 Jan 19; 10(1). PMID: 30654440    Free PMC article.
Review.
Principles of Resistance to Targeted Cancer Therapy: Lessons from Basic and Translational Cancer Biology.
Amit J Sabnis, Trever G Bivona.
Trends Mol Med, 2019 Jan 29; 25(3). PMID: 30686761    Free PMC article.
Highly Cited. Review.
Pin1 inhibition potently suppresses gastric cancer growth and blocks PI3K/AKT and Wnt/β-catenin oncogenic pathways.
Zhenzhen Zhang, Weixing Yu, +9 authors, Kun Ping Lu.
Mol Carcinog, 2019 Apr 27; 58(8). PMID: 31026381    Free PMC article.
Finding driver mutations in cancer: Elucidating the role of background mutational processes.
Anna-Leigh Brown, Minghui Li, Alexander Goncearenco, Anna R Panchenko.
PLoS Comput Biol, 2019 Apr 30; 15(4). PMID: 31034466    Free PMC article.
Liquid biopsy in pancreatic ductal adenocarcinoma: current status of circulating tumor cells and circulating tumor DNA.
Jee-Soo Lee, Sung Sup Park, +2 authors, Stefanie S Jeffrey.
Mol Oncol, 2019 Jun 28; 13(8). PMID: 31243883    Free PMC article.
Review.
Evolving neoantigen profiles in colorectal cancers with DNA repair defects.
Giuseppe Rospo, Annalisa Lorenzato, +16 authors, Alberto Bardelli.
Genome Med, 2019 Jun 30; 11(1). PMID: 31253177    Free PMC article.
Acquired EGFR L718V Mutation as the Mechanism for Osimertinib Resistance in a T790M-Negative Non-Small-Cell Lung Cancer Patient.
Zhe Yang, Jinqi Yang, +2 authors, Xing Wang.
Target Oncol, 2019 Jul 14; 14(4). PMID: 31301016
Bioinspired lipoproteins-mediated photothermia remodels tumor stroma to improve cancer cell accessibility of second nanoparticles.
Tao Tan, Haiyan Hu, +6 authors, Yaping Li.
Nat Commun, 2019 Jul 28; 10(1). PMID: 31346166    Free PMC article.
Cooperative adaptation to therapy (CAT) confers resistance in heterogeneous non-small cell lung cancer.
Morgan Craig, Kamran Kaveh, +10 authors, Aaron Goldman.
PLoS Comput Biol, 2019 Aug 27; 15(8). PMID: 31449515    Free PMC article.
Hybrid manganese dioxide-bovine serum albumin nanostructure incorporated with doxorubicin and IR780 for enhanced breast cancer chemo-photothermal therapy.
Xiao Yuan, Yanlong Yin, +2 authors, Qian Yang.
Drug Deliv, 2019 Nov 26; 26(1). PMID: 31760842    Free PMC article.
DNA Methylation Cancer Biomarkers: Translation to the Clinic.
Warwick J Locke, Dominic Guanzon, +4 authors, Jason P Ross.
Front Genet, 2019 Dec 06; 10. PMID: 31803237    Free PMC article.
Review.
Alleviation of Multidrug Resistance by Flavonoid and Non-Flavonoid Compounds in Breast, Lung, Colorectal and Prostate Cancer.
Teodora Costea, Oana Cezara Vlad, +3 authors, Maria-Magdalena Mocanu.
Int J Mol Sci, 2020 Jan 16; 21(2). PMID: 31936346    Free PMC article.
Review.
Uncovering Differently Expressed Markers and Heterogeneity on Human Pancreatic Cancer.
Sorah Yoon, Haiqing Li, +2 authors, John J Rossi.
Transl Oncol, 2020 Mar 07; 13(3). PMID: 32143178    Free PMC article.
From single gene analysis to single cell profiling: a new era for precision medicine.
Maria Teresa Di Martino, Stefania Meschini, +6 authors, Michele Caraglia.
J Exp Clin Cancer Res, 2020 Mar 07; 39(1). PMID: 32138788    Free PMC article.
Preserving Single Cells in Space and Time for Analytical Assays.
Luke A Gallion, Matthew M Anttila, +2 authors, Nancy L Allbritton.
Trends Analyt Chem, 2020 Mar 11; 122. PMID: 32153309    Free PMC article.
A non-linear association between blood tumor mutation burden and prognosis in NSCLC patients receiving atezolizumab.
Wei Nie, Jie Qian, +15 authors, Bao-Hui Han.
Oncoimmunology, 2020 Mar 12; 9(1). PMID: 32158623    Free PMC article.
A Biomimetic Tumor Model of Heterogeneous Invasion in Pancreatic Ductal Adenocarcinoma.
Michael J Bradney, Stephanie M Venis, +2 authors, Bumsoo Han.
Small, 2020 Jan 31; 16(10). PMID: 31997571    Free PMC article.
Role of texture analysis in breast MRI as a cancer biomarker: A review.
Rhea D Chitalia, Despina Kontos.
J Magn Reson Imaging, 2018 Nov 06; 49(4). PMID: 30390383    Free PMC article.
Review.
Targeting the RNA Polymerase I Transcription for Cancer Therapy Comes of Age.
Rita Ferreira, John S Schneekloth, +2 authors, Ross D Hannan.
Cells, 2020 Jan 25; 9(2). PMID: 31973211    Free PMC article.
Review.
Downregulation of RIG-I mediated by ITGB3/c-SRC/STAT3 signaling confers resistance to interferon-α-induced apoptosis in tumor-repopulating cells of melanoma.
Yong Li, Yingqiu Song, +16 authors, Fengjun Cao.
J Immunother Cancer, 2020 Mar 11; 8(1). PMID: 32152220    Free PMC article.
Inter- and intratumor DNA methylation heterogeneity associated with lymph node metastasis and prognosis of esophageal squamous cell carcinoma.
Huajing Teng, Meiying Xue, +12 authors, Zhongsheng Sun.
Theranostics, 2020 Mar 21; 10(7). PMID: 32194853    Free PMC article.
Machine Learning Analysis of Individual Tumor Lesions in Four Metastatic Colorectal Cancer Clinical Studies: Linking Tumor Heterogeneity to Overall Survival.
Diego Vera-Yunca, Pascal Girard, +3 authors, Nadia Terranova.
AAPS J, 2020 Mar 19; 22(3). PMID: 32185612    Free PMC article.
Loss of RNF40 Decreases NF-κB Activity in Colorectal Cancer Cells and Reduces Colitis Burden in Mice.
Robyn Laura Kosinsky, Robert Lorenz Chua, +7 authors, Steven A Johnsen.
J Crohns Colitis, 2018 Oct 16; 13(3). PMID: 30321325    Free PMC article.
Patient-Specific Tumor Growth Trajectories Determine Persistent and Resistant Cancer Cell Populations during Treatment with Targeted Therapies.
Clemens Grassberger, David McClatchy, +8 authors, Harald Paganetti.
Cancer Res, 2019 May 23; 79(14). PMID: 31113818    Free PMC article.
Commonly integrated epigenetic modifications of differentially expressed genes lead to adaptive resistance in cancer.
Abdullah Al Emran, Diego M Marzese, +6 authors, Helmut Schaider.
Epigenomics, 2019 May 10; 11(7). PMID: 31070054    Free PMC article.
Lipidome-based rapid diagnosis with machine learning for detection of TGF-β signalling activated area in head and neck cancer.
Hiroki Ishii, Masao Saitoh, +8 authors, Kentaro Yoshimura.
Br J Cancer, 2020 Feb 06; 122(7). PMID: 32020064    Free PMC article.
Selective imaging of solid tumours via the calcium-dependent high-affinity binding of a cyclic octapeptide to phosphorylated Annexin A2.
Duanwen Shen, Baogang Xu, +18 authors, Samuel Achilefu.
Nat Biomed Eng, 2020 Mar 14; 4(3). PMID: 32165732    Free PMC article.
Adaptive RSK-EphA2-GPRC5A signaling switch triggers chemotherapy resistance in ovarian cancer.
Lidia Moyano-Galceran, Elina A Pietilä, +13 authors, Kaisa Lehti.
EMBO Mol Med, 2020 Mar 03; 12(4). PMID: 32115889    Free PMC article.
Impact of Next-Generation Sequencing on Outcomes in Hepatocellular Carcinoma: How Precise Are We Really?
Dana A Dominguez, Xin Wei Wang.
J Hepatocell Carcinoma, 2020 Apr 08; 7. PMID: 32257970    Free PMC article.
Review.
Synergistic Inhibition of Kinase Pathways Overcomes Resistance of Colorectal Cancer Spheroids to Cyclic Targeted Therapies.
Pradip Shahi Thakuri, Megha Gupta, +2 authors, Hossein Tavana.
ACS Pharmacol Transl Sci, 2020 Apr 08; 2(4). PMID: 32259061    Free PMC article.
Potential Applications of NRF2 Modulators in Cancer Therapy.
Emiliano Panieri, Aleksandra Buha, +8 authors, Luciano Saso.
Antioxidants (Basel), 2020 Feb 29; 9(3). PMID: 32106613    Free PMC article.
Review.
Role of eIF4E on epithelial-mesenchymal transition, invasion, and chemoresistance of prostate cancer cells.
Xujie Liu, Amita M Vaidya, +4 authors, Zheng-Rong Lu.
Cancer Commun (Lond), 2020 Mar 20; 40(2-3). PMID: 32189455    Free PMC article.
CancerTracer: a curated database for intrapatient tumor heterogeneity.
Chen Wang, Jian Yang, +6 authors, Haoyang Cai.
Nucleic Acids Res, 2019 Nov 09; 48(D1). PMID: 31701131    Free PMC article.
A 3D Cell Death Assay to Quantitatively Determine Ferroptosis in Spheroids.
Robin Demuynck, Iuliia Efimova, +2 authors, Dmitri V Krysko.
Cells, 2020 Mar 19; 9(3). PMID: 32183000    Free PMC article.
MEK1/2 Inhibitors Unlock the Constrained Interferon Response in Macrophages Through IRF1 Signaling.
Lei Yang, Jeak Ling Ding.
Front Immunol, 2019 Sep 12; 10. PMID: 31507609    Free PMC article.
Live single cell mass spectrometry reveals cancer-specific metabolic profiles of circulating tumor cells.
Yasmine Abouleila, Kaoru Onidani, +11 authors, Kazufumi Honda.
Cancer Sci, 2018 Dec 15; 110(2). PMID: 30549153    Free PMC article.
Overcoming Endocrine Resistance in Breast Cancer.
Ariella B Hanker, Dhivya R Sudhan, Carlos L Arteaga.
Cancer Cell, 2020 Apr 15; 37(4). PMID: 32289273    Free PMC article.
Review.
Role of Albumin in Accumulation and Persistence of Tumor-Seeking Cyanine Dyes.
Syed Muhammad Usama, G Kate Park, +3 authors, Kevin Burgess.
Bioconjug Chem, 2020 Jan 08; 31(2). PMID: 31909595    Free PMC article.
The Role of Exosomal microRNA in Cancer Drug Resistance.
Qiao-Ru Guo, Hui Wang, +7 authors, Jian-Ye Zhang.
Front Oncol, 2020 Apr 23; 10. PMID: 32318350    Free PMC article.
Review.
Cell-state dynamics and therapeutic resistance in melanoma from the perspective of MITF and IFNγ pathways.
Xue Bai, David E Fisher, Keith T Flaherty.
Nat Rev Clin Oncol, 2019 Apr 11; 16(9). PMID: 30967646    Free PMC article.
Highly Cited. Review.
3-Aryl-4-nitrobenzothiochromans S,S-dioxide: From Calcium-Channel Modulators Properties to Multidrug-Resistance Reverting Activity.
Matteo Micucci, Maurizio Viale, +7 authors, Roberta Budriesi.
Molecules, 2020 Mar 04; 25(5). PMID: 32120861    Free PMC article.
Machine Learning-Guided Prediction of Antigen-Reactive In Silico Clonotypes Based on Changes in Clonal Abundance through Bio-Panning.
Duck Kyun Yoo, Seung Ryul Lee, +7 authors, Junho Chung.
Biomolecules, 2020 Mar 19; 10(3). PMID: 32182714    Free PMC article.
The Role of Nicotinamide in Cancer Chemoprevention and Therapy.
Ilias P Nikas, Stavroula A Paschou, Han Suk Ryu.
Biomolecules, 2020 Apr 05; 10(3). PMID: 32245130    Free PMC article.
Review.
Prognostic significance of mutant-allele tumor heterogeneity in uterine corpus endometrial carcinoma.
Yufang Hou, Tiegang Li, +5 authors, Min Yang.
Ann Transl Med, 2020 May 02; 8(6). PMID: 32355783    Free PMC article.
CAR T cells and checkpoint inhibition for the treatment of glioblastoma.
Steven H Shen, Karolina Woroniecka, +3 authors, John H Sampson.
Expert Opin Biol Ther, 2020 Feb 07; 20(6). PMID: 32027536    Free PMC article.
Review.
HDAC Inhibitor, CG-745, Enhances the Anti-Cancer Effect of Anti-PD-1 Immune Checkpoint Inhibitor by Modulation of the Immune Microenvironment.
Young-Dae Kim, Sang-Min Park, +5 authors, Joong Myung Cho.
J Cancer, 2020 May 06; 11(14). PMID: 32368288    Free PMC article.
Micellar Formulation of Talazoparib and Buparlisib for Enhanced DNA Damage in Breast Cancer Chemoradiotherapy.
Allison N DuRoss, Megan J Neufeld, +5 authors, Conroy Sun.
ACS Appl Mater Interfaces, 2019 Mar 13; 11(13). PMID: 30860347    Free PMC article.
Cellular rewiring in lethal prostate cancer: the architect of drug resistance.
Marc Carceles-Cordon, W Kevin Kelly, +3 authors, Josep Domingo-Domenech.
Nat Rev Urol, 2020 Mar 24; 17(5). PMID: 32203305    Free PMC article.
Review.
Efficacy of direct current generated by multiple-electrode arrays on F3II mammary carcinoma: experiment and mathematical modeling.
Narciso Antonio Villar Goris, Jorge Luis García Rodríguez, +16 authors, Luis Enrique Bergues Cabrales.
J Transl Med, 2020 May 10; 18(1). PMID: 32381006    Free PMC article.
Metastatic Heterogeneity of Breast Cancer: Companion and Theranostic Approach in Nuclear Medicine.
Christopher Montemagno, Gilles Pagès.
Cancers (Basel), 2020 Apr 03; 12(4). PMID: 32235331    Free PMC article.
Review.
L-Glucose: Another Path to Cancer Cells.
Koki Ono, Shota Takigawa, Katsuya Yamada.
Cancers (Basel), 2020 Apr 05; 12(4). PMID: 32244695    Free PMC article.
Review.
MicroRNAs as Emerging Regulators of Signaling in the Tumor Microenvironment.
Shahzad Nawaz Syed, Bernhard Brüne.
Cancers (Basel), 2020 Apr 12; 12(4). PMID: 32276464    Free PMC article.
Review.
Glioblastoma: Pathogenesis and Current Status of Chemotherapy and Other Novel Treatments.
Vilashini Rajaratnam, Mohammad Mohiminul Islam, +3 authors, Shama Parveen Mirza.
Cancers (Basel), 2020 Apr 16; 12(4). PMID: 32290213    Free PMC article.
Review.
Personalized Medicine: Recent Progress in Cancer Therapy.
Valentina Gambardella, Noelia Tarazona, +6 authors, Andres Cervantes.
Cancers (Basel), 2020 Apr 25; 12(4). PMID: 32325878    Free PMC article.
Review.
Cancer Stem Cell Plasticity - A Deadly Deal.
Archana P Thankamony, Kritika Saxena, +2 authors, Radhika Nair.
Front Mol Biosci, 2020 May 20; 7. PMID: 32426371    Free PMC article.
Review.
Detecting TRA-1-60 in Cancer via a Novel Zr-89 Labeled ImmunoPET Imaging Agent.
Jordan M White, Akhila N Kuda-Wedagedara, +4 authors, Nerissa T Viola.
Mol Pharm, 2020 Feb 19; 17(4). PMID: 32069422    Free PMC article.
Tumor radiomic features complement clinico-radiological factors in predicting long-term local control and laryngectomy free survival in locally advanced laryngo-pharyngeal cancers.
Jai Prakash Agarwal, Shwetabh Sinha, +9 authors, Balaji Ganeshan.
Br J Radiol, 2020 Feb 27; 93(1109). PMID: 32101463    Free PMC article.
Targeting tumor phenotypic plasticity and metabolic remodeling in adaptive cross-drug tolerance.
Aaron Goldman, Sachin Khiste, +13 authors, Shiladitya Sengupta.
Sci Signal, 2019 Aug 23; 12(595). PMID: 31431543    Free PMC article.
Resistance is not the end: lessons from pest management.
Christopher J Whelan, Jessica J Cunningham.
Cancer Control, 2020 May 15; 27(1). PMID: 32407140    Free PMC article.
Convergent Evolution, Evolving Evolvability, and the Origins of Lethal Cancer.
Kenneth J Pienta, Emma U Hammarlund, +2 authors, Joel S Brown.
Mol Cancer Res, 2020 Apr 03; 18(6). PMID: 32234827    Free PMC article.
Review.
Review of precision cancer medicine: Evolution of the treatment paradigm.
Apostolia M Tsimberidou, Elena Fountzilas, Mina Nikanjam, Razelle Kurzrock.
Cancer Treat Rev, 2020 Apr 07; 86. PMID: 32251926    Free PMC article.
Review.
Biomedical Research Goes Viral: Dangers and Opportunities.
Eleftheria Zeggini, Michael Baumann, +3 authors, Matthias H Tschöp.
Cell, 2020 May 23; 181(6). PMID: 32442404    Free PMC article.
Liquid biopsy and tumor heterogeneity in metastatic solid tumors: the potentiality of blood samples.
Marco Russano, Andrea Napolitano, +12 authors, Daniele Santini.
J Exp Clin Cancer Res, 2020 May 29; 39(1). PMID: 32460897    Free PMC article.
Review.
Malignant adenomyoepithelioma of the breast.
Kazuki Moro, Eiko Sakata, +3 authors, Haruhiko Makino.
Surg Case Rep, 2020 May 31; 6(1). PMID: 32472226    Free PMC article.
The p53-53BP1-Related Survival of A549 and H1299 Human Lung Cancer Cells after Multifractionated Radiotherapy Demonstrated Different Response to Additional Acute X-ray Exposure.
Margarita Pustovalova, Lina Alhaddad, +5 authors, Sergey Leonov.
Int J Mol Sci, 2020 May 14; 21(9). PMID: 32397297    Free PMC article.
Tspan8 Drives Melanoma Dermal Invasion by Promoting ProMMP-9 Activation and Basement Membrane Proteolysis in a Keratinocyte-Dependent Manner.
Manale El Kharbili, Muriel Cario, +5 authors, Odile Berthier-Vergnes.
Cancers (Basel), 2020 May 28; 12(5). PMID: 32455575    Free PMC article.
A modeling platform for the lymphatic system.
Javier Ruiz-Ramírez, Arturas Ziemys, Prashant Dogra, Mauro Ferrari.
J Theor Biol, 2020 Mar 03; 493. PMID: 32119968    Free PMC article.
Prognostic value of HER2 status on circulating tumor cells in advanced-stage breast cancer patients with HER2-negative tumors.
Chun Wang, Zhaomei Mu, +22 authors, Hushan Yang.
Breast Cancer Res Treat, 2020 May 06; 181(3). PMID: 32367460    Free PMC article.
Prospects for Comprehensive Analyses of Circulating Tumor Cells in Tumor Biology.
Masahiko Aoki, Hirokazu Shoji, +3 authors, Kazufumi Honda.
Cancers (Basel), 2020 May 07; 12(5). PMID: 32369927    Free PMC article.
Review.
Oncogene-Addicted Non-Small-Cell Lung Cancer: Treatment Opportunities and Future Perspectives.
Miriam Grazia Ferrara, Vincenzo Di Noia, +8 authors, Emilio Bria.
Cancers (Basel), 2020 May 14; 12(5). PMID: 32397295    Free PMC article.
Review.
Whole Genome Analysis of Ovarian Granulosa Cell Tumors Reveals Tumor Heterogeneity and a High-Grade TP53-Specific Subgroup.
Joline Roze, Glen Monroe, +13 authors, Ronald Zweemer.
Cancers (Basel), 2020 May 28; 12(5). PMID: 32455687    Free PMC article.
The genomic landscape of metastasis in treatment-naïve breast cancer models.
Christina Ross, Karol Szczepanek, +4 authors, Kent Hunter.
PLoS Genet, 2020 May 29; 16(5). PMID: 32463822    Free PMC article.
Early stratification of radiotherapy response by activatable inflammation magnetic resonance imaging.
Zijian Zhou, Hongzhang Deng, +14 authors, Xiaoyuan Chen.
Nat Commun, 2020 Jun 17; 11(1). PMID: 32541769    Free PMC article.
Agent-Based Models Predict Emergent Behavior of Heterogeneous Cell Populations in Dynamic Microenvironments.
Jessica S Yu, Neda Bagheri.
Front Bioeng Biotechnol, 2020 Jul 01; 8. PMID: 32596213    Free PMC article.
Advances and potential pitfalls of oncolytic viruses expressing immunomodulatory transgene therapy for malignant gliomas.
Qing Zhang, Fusheng Liu.
Cell Death Dis, 2020 Jun 27; 11(6). PMID: 32587256    Free PMC article.
Review.
Viral nanoparticles for drug delivery, imaging, immunotherapy, and theranostic applications.
Young Hun Chung, Hui Cai, Nicole F Steinmetz.
Adv Drug Deliv Rev, 2020 Jul 01; 156. PMID: 32603813    Free PMC article.
Review.
Expression of ncRNAs on the DLK1-DIO3 Locus Is Associated With Basal and Mesenchymal Phenotype in Breast Epithelial Progenitor Cells.
Zuzana Budkova, Anna Karen Sigurdardottir, +6 authors, Bylgja Hilmarsdottir.
Front Cell Dev Biol, 2020 Jul 03; 8. PMID: 32612992    Free PMC article.
Beyond finding druggable targets and tumor mutational burden: to measure heterogeneity by ctDNA.
Zhichao Liu, Jianxing He, Wenhua Liang.
Ann Transl Med, 2020 Jul 04; 8(11). PMID: 32617343    Free PMC article.
Overcoming cancer therapeutic bottleneck by drug repurposing.
Zhe Zhang, Li Zhou, +4 authors, Canhua Huang.
Signal Transduct Target Ther, 2020 Jul 04; 5(1). PMID: 32616710    Free PMC article.
Review.
Deterministic culturing of single cells in 3D.
Rohil Jain, Shirisha Chittiboyina, +2 authors, Cagri A Savran.
Sci Rep, 2020 Jul 04; 10(1). PMID: 32616817    Free PMC article.
The Potential of Tumor Debulking to Support Molecular Targeted Therapies.
Felix Oppel, Martin Görner, Holger Sudhoff.
Front Oncol, 2020 Jul 07; 10. PMID: 32626653    Free PMC article.
Post-mortem tissue donation programs as platforms to accelerate cancer research.
Matthew Dankner, Badia Issa-Chergui, Nathaniel Bouganim.
J Pathol Clin Res, 2020 Mar 22; 6(3). PMID: 32198850    Free PMC article.
Single-cell RNA-seq reveals that glioblastoma recapitulates a normal neurodevelopmental hierarchy.
Charles P Couturier, Shamini Ayyadhury, +17 authors, Kevin Petrecca.
Nat Commun, 2020 Jul 10; 11(1). PMID: 32641768    Free PMC article.
Multiphase computed tomography radiomics of pancreatic intraductal papillary mucinous neoplasms to predict malignancy.
Stuart L Polk, Jung W Choi, +10 authors, Daniel Jeong.
World J Gastroenterol, 2020 Jul 14; 26(24). PMID: 32655269    Free PMC article.
Genomic instability and cancer: lessons from Drosophila.
Stephan U Gerlach, Héctor Herranz.
Open Biol, 2020 Jun 03; 10(6). PMID: 32485126    Free PMC article.
Review.
A Driver Never Works Alone-Interplay Networks of Mutant p53, MYC, RAS, and Other Universal Oncogenic Drivers in Human Cancer.
Maria Grzes, Magdalena Oron, +3 authors, Dawid Walerych.
Cancers (Basel), 2020 Jun 18; 12(6). PMID: 32545208    Free PMC article.
Review.
Whole Exome Sequencing of Multi-Regional Biopsies from Metastatic Lesions to Evaluate Actionable Truncal Mutations Using a Single-Pass Percutaneous Technique.
Valerie Heong, Darwin Tay, +15 authors, David Sp Tan.
Cancers (Basel), 2020 Jun 21; 12(6). PMID: 32560395    Free PMC article.
Culture and application of conditionally reprogrammed primary tumor cells.
Mengjun Zhong, Liwu Fu.
Gastroenterol Rep (Oxf), 2020 Jul 16; 8(3). PMID: 32665854    Free PMC article.
Review.
Increased number of subclones in lung squamous cell carcinoma elicits overexpression of immune related genes.
Myung Jin Song, Sang Hoon Lee, Eun Young Kim, Yoon Soo Chang.
Transl Lung Cancer Res, 2020 Jul 18; 9(3). PMID: 32676328    Free PMC article.
Integrated analysis of optical mapping and whole-genome sequencing reveals intratumoral genetic heterogeneity in metastatic lung squamous cell carcinoma.
Yizhou Peng, Chongze Yuan, +9 authors, Yihua Sun.
Transl Lung Cancer Res, 2020 Jul 18; 9(3). PMID: 32676329    Free PMC article.
Deciphering high risk molecular alterations in gastrointestinal malignancy utilizing an extreme outlier strategy.
Austin R Dosch, Siddharth Mehra, Nipun B Merchant, Jashodeep Datta.
Oncoscience, 2020 Jul 18; 7(5-6). PMID: 32676512    Free PMC article.
Paclitaxel and Sorafenib: The Effective Combination of Suppressing the Self-Renewal of Cancer Stem Cells.
Hend M Nawara, Said M Afify, +10 authors, Masaharu Seno.
Cancers (Basel), 2020 May 30; 12(6). PMID: 32466563    Free PMC article.
The Cancer Chemopreventive and Therapeutic Potential of Tetrahydrocurcumin.
Ching-Shu Lai, Chi-Tang Ho, Min-Hsiung Pan.
Biomolecules, 2020 Jun 04; 10(6). PMID: 32486019    Free PMC article.
Review.
Role of Exosomal miRNAs and the Tumor Microenvironment in Drug Resistance.
Patrick Santos, Fausto Almeida.
Cells, 2020 Jun 18; 9(6). PMID: 32545155    Free PMC article.
Review.
Dihydropyrimidinase-related protein 5 controls glioblastoma stem cell characteristics as a biomarker of proneural-subtype glioblastoma stem cells.
Min Gi Park, Sunyoung Seo, +2 authors, Hyunggee Kim.
Oncol Lett, 2020 Jul 30; 20(2). PMID: 32724355    Free PMC article.
Programmed death ligand-1 expression in gastrointestinal cancer: Clinical significance and future challenges.
Kohei Yamashita, Masaaki Iwatsuki, Jaffer A Ajani, Hideo Baba.
Ann Gastroenterol Surg, 2020 Jul 30; 4(4). PMID: 32724880    Free PMC article.
Review.
Ascorbate sensitizes human osteosarcoma cells to the cytostatic effects of cisplatin.
Naohiro Oka, Akiyoshi Komuro, +7 authors, Hitoshi Okada.
Pharmacol Res Perspect, 2020 Jul 30; 8(4). PMID: 32725721    Free PMC article.
Unveiling functional heterogeneity in breast cancer multicellular tumor spheroids through single-cell RNA-seq.
Erick Andrés Muciño-Olmos, Aarón Vázquez-Jiménez, +5 authors, Osbaldo Resendis-Antonio.
Sci Rep, 2020 Jul 31; 10(1). PMID: 32728097    Free PMC article.
Lipid and protein tumor markers for head and neck squamous cell carcinoma identified by imaging mass spectrometry.
Janos Schmidt, Béla Kajtár, +10 authors, Zsolt Balogi.
Oncotarget, 2020 Aug 01; 11(28). PMID: 32733643    Free PMC article.
Towards systems tissue engineering: Elucidating the dynamics, spatial coordination, and individual cells driving emergent behaviors.
Matthew S Hall, Joseph T Decker, Lonnie D Shea.
Biomaterials, 2020 Jun 23; 255. PMID: 32569865    Free PMC article.
Review.
Intratumoral heterogeneity of hepatocellular carcinoma: From single-cell to population-based studies.
Qi Zhang, Yu Lou, Xue-Li Bai, Ting-Bo Liang.
World J Gastroenterol, 2020 Aug 11; 26(26). PMID: 32774053    Free PMC article.
Review.
Modulated Electro-Hyperthermia Resolves Radioresistance of Panc1 Pancreas Adenocarcinoma and Promotes DNA Damage and Apoptosis In Vitro.
Gertrud Forika, Andrea Balogh, +4 authors, Tibor Krenacs.
Int J Mol Sci, 2020 Jul 28; 21(14). PMID: 32707717    Free PMC article.
High mutation burden of circulating cell-free DNA in early-stage breast cancer patients is associated with a poor relapse-free survival.
Jouni Kujala, Jaana M Hartikainen, +3 authors, Arto Mannermaa.
Cancer Med, 2020 Jul 01; 9(16). PMID: 32602248    Free PMC article.
Methods for copy number aberration detection from single-cell DNA-sequencing data.
Xian F Mallory, Mohammadamin Edrisi, Nicholas Navin, Luay Nakhleh.
Genome Biol, 2020 Aug 19; 21(1). PMID: 32807205    Free PMC article.
Review.
CRISPR and transposon in vivo screens for cancer drivers and therapeutic targets.
Imran Noorani, Allan Bradley, Jorge de la Rosa.
Genome Biol, 2020 Aug 20; 21(1). PMID: 32811551    Free PMC article.
Review.
Pharmacokinetic Profiles Determine Optimal Combination Treatment Schedules in Computational Models of Drug Resistance.
Itziar Irurzun-Arana, Thomas O McDonald, Iñaki F Trocóniz, Franziska Michor.
Cancer Res, 2020 Jun 21; 80(16). PMID: 32561532    Free PMC article.
Pre-Treatment T2-WI Based Radiomics Features for Prediction of Locally Advanced Rectal Cancer Non-Response to Neoadjuvant Chemoradiotherapy: A Preliminary Study.
Bianca Petresc, Andrei Lebovici, +3 authors, Mircea Marian Buruian.
Cancers (Basel), 2020 Jul 18; 12(7). PMID: 32674345    Free PMC article.
Mathematical modelling reveals cellular dynamics within tumour spheroids.
Joshua A Bull, Franziska Mech, +2 authors, Helen M Byrne.
PLoS Comput Biol, 2020 Aug 19; 16(8). PMID: 32810174    Free PMC article.
Non-Small-Cell Lung Cancer-Sensitive Detection of the p.Thr790Met EGFR Alteration by Preamplification before PNA-Mediated PCR Clamping and Pyrosequencing.
Amandine Billaud, Veronique Verriele, +2 authors, Alain Morel.
Diagnostics (Basel), 2020 Aug 06; 10(8). PMID: 32751202    Free PMC article.
In Vitro Modeling of Non-Solid Tumors: How Far Can Tissue Engineering Go?
Sandra Clara-Trujillo, Gloria Gallego Ferrer, José Luis Gómez Ribelles.
Int J Mol Sci, 2020 Aug 17; 21(16). PMID: 32796596    Free PMC article.
Review.
Novel Somatic Genetic Variants as Predictors of Resistance to EGFR-Targeted Therapies in Metastatic Colorectal Cancer Patients.
Pau Riera, Benjamín Rodríguez-Santiago, +9 authors, David Páez.
Cancers (Basel), 2020 Aug 17; 12(8). PMID: 32796636    Free PMC article.
Eco-oncology: Applying ecological principles to understand and manage cancer.
Brent A Reynolds, Monika W Oli, Madan K Oli.
Ecol Evol, 2020 Sep 05; 10(16). PMID: 32884638    Free PMC article.
Review.
Optimizing the sequencing of tyrosine kinase inhibitors (TKIs) in epidermal growth factor receptor (EGFR) mutation-positive non-small cell lung cancer (NSCLC).
Ana C Z Gelatti, Alexander Drilon, Fernando C Santini.
Lung Cancer, 2019 Oct 01; 137. PMID: 31568888    Free PMC article.
Review.
Environmental Carcinogenesis at the Single-Cell Level.
Gregory Chang, Kohei Saeki, Hitomi Mori, Shiuan Chen.
Cancer Epidemiol Biomarkers Prev, 2020 Mar 07; 29(10). PMID: 32132147    Free PMC article.
Genetic Heterogeneity Between Paired Primary and Brain Metastases in Lung Adenocarcinoma.
Li Li, Zhulin Liu, +4 authors, Yong He.
Clin Med Insights Oncol, 2020 Sep 15; 14. PMID: 32922114    Free PMC article.
Carbonic Anhydrase 4 serves as a Clinicopathological Biomarker for Outcomes and Immune Infiltration in Renal Cell Carcinoma, Lower Grade Glioma, Lung Adenocarcinoma and Uveal Melanoma.
Yue Xu, Wen-Hao Xu, +6 authors, Xiao-Feng Zhang.
J Cancer, 2020 Sep 15; 11(20). PMID: 32922550    Free PMC article.
Clinical Relevance of an Amplicon-Based Liquid Biopsy for Detecting ALK and ROS1 Fusion and Resistance Mutations in Patients With Non-Small-Cell Lung Cancer.
Laura Mezquita, Aurélie Swalduz, +27 authors, Pierre Saintigny.
JCO Precis Oncol, 2020 Sep 15; 4. PMID: 32923908    Free PMC article.
Tumor immune profiles noninvasively estimated by FDG PET with deep learning correlate with immunotherapy response in lung adenocarcinoma.
Changhee Park, Kwon Joong Na, +14 authors, Dae Seog Heo.
Theranostics, 2020 Sep 16; 10(23). PMID: 32929383    Free PMC article.
Feasibility and first reports of the MATCH-R repeated biopsy trial at Gustave Roussy.
Gonzalo Recondo, Linda Mahjoubi, +31 authors, Luc Friboulet.
NPJ Precis Oncol, 2020 Sep 24; 4. PMID: 32964129    Free PMC article.
Gut Microbiota and Cancer: From Pathogenesis to Therapy.
Silvia Vivarelli, Rossella Salemi, +7 authors, Massimo Libra.
Cancers (Basel), 2019 Jan 06; 11(1). PMID: 30609850    Free PMC article.
Highly Cited. Review.
A Systematic Review of miR-29 in Cancer.
Jason J Kwon, Tricia D Factora, Shatovisha Dey, Janaiah Kota.
Mol Ther Oncolytics, 2019 Feb 23; 12. PMID: 30788428    Free PMC article.
Highly Cited. Review.
Conversion of Stem Cells to Cancer Stem Cells: Undercurrent of Cancer Initiation.
Said M Afify, Masaharu Seno.
Cancers (Basel), 2019 Mar 14; 11(3). PMID: 30862050    Free PMC article.
Highly Cited. Review.
The Impact of Heterogeneity on Single-Cell Sequencing.
Samantha L Goldman, Matthew MacKay, +3 authors, Christopher E Mason.
Front Genet, 2019 Mar 19; 10. PMID: 30881372    Free PMC article.
Salmonella-Based Targeted Cancer Therapy: Updates on A Promising and Innovative Tumor Immunotherapeutic Strategy.
Christian Ronquillo Pangilinan, Che-Hsin Lee.
Biomedicines, 2019 May 06; 7(2). PMID: 31052558    Free PMC article.
Review.
Perturbational Gene-Expression Signatures for Combinatorial Drug Discovery.
Chen-Tsung Huang, Chiao-Hui Hsieh, +3 authors, Hsueh-Fen Juan.
iScience, 2019 May 19; 15. PMID: 31102995    Free PMC article.
Metadherin: A Therapeutic Target in Multiple Cancers.
Gourav Dhiman, Neha Srivastava, +7 authors, Manoj Baranwal.
Front Oncol, 2019 May 28; 9. PMID: 31131259    Free PMC article.
Review.
Theranostics in Interventional Oncology: Versatile Carriers for Diagnosis and Targeted Image-Guided Minimally Invasive Procedures.
Nils Degrauwe, Arnaud Hocquelet, +3 authors, Rafael Duran.
Front Pharmacol, 2019 May 31; 10. PMID: 31143114    Free PMC article.
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Aerosolization of Nanotherapeutics as a Newly Emerging Treatment Regimen for Peritoneal Carcinomatosis.
Molood Shariati, Wouter Willaert, +2 authors, Katrien Remaut.
Cancers (Basel), 2019 Jul 03; 11(7). PMID: 31261685    Free PMC article.
Review.
Phenotypic characterization of the novel, non-hotspot oncogenic KRAS mutants E31D and E63K.
Arlou Kristina J Angeles, Ryan Timothy D Yu, Eva Maria Cutiongco-De La Paz, Reynaldo L Garcia.
Oncol Lett, 2019 Jul 11; 18(1). PMID: 31289513    Free PMC article.
Diverse Stakeholders of Tumor Metabolism: An Appraisal of the Emerging Approach of Multifaceted Metabolic Targeting by 3-Bromopyruvate.
Saveg Yadav, Shrish Kumar Pandey, +2 authors, Sukh Mahendra Singh.
Front Pharmacol, 2019 Jul 25; 10. PMID: 31333455    Free PMC article.
Review.
The Role of Peroxiredoxin Family in Cancer Signaling.
Yosup Kim, Ho Hee Jang.
J Cancer Prev, 2019 Jul 31; 24(2). PMID: 31360686    Free PMC article.
Review.
A PD-L1-Based Cancer Vaccine Elicits Antitumor Immunity in a Mouse Melanoma Model.
Zhibing Lin, Yan Zhang, +4 authors, Rongxiu Li.
Mol Ther Oncolytics, 2019 Aug 07; 14. PMID: 31384666    Free PMC article.
EMT and Stemness-Key Players in Pancreatic Cancer Stem Cells.
Eva Rodriguez-Aznar, Lisa Wiesmüller, Bruno Sainz, Patrick C Hermann.
Cancers (Basel), 2019 Aug 11; 11(8). PMID: 31398893    Free PMC article.
Review.
The Promise of Digital Biopsy for the Prediction of Tumor Molecular Features and Clinical Outcomes Associated With Immunotherapy.
Giuseppe Luigi Banna, Timothée Olivier, +4 authors, Alfredo Addeo.
Front Med (Lausanne), 2019 Aug 17; 6. PMID: 31417906    Free PMC article.
Single-Cell Analysis of Multiple Steps of Dynamic NF-κB Regulation in Interleukin-1α-Triggered Tumor Cells Using Proximity Ligation Assays.
Christin Mayr-Buro, Eva Schlereth, +4 authors, Michael Kracht.
Cancers (Basel), 2019 Aug 21; 11(8). PMID: 31426445    Free PMC article.
Cell death-related molecules and biomarkers for renal cell carcinoma targeted therapy.
Yongchang Lai, Tao Zeng, +3 authors, Wenqi Wu.
Cancer Cell Int, 2019 Aug 30; 19. PMID: 31462894    Free PMC article.
Review.
Innovative approaches for cancer treatment: current perspectives and new challenges.
Carlotta Pucci, Chiara Martinelli, Gianni Ciofani.
Ecancermedicalscience, 2019 Sep 21; 13. PMID: 31537986    Free PMC article.
New insights into small-cell lung cancer development and therapy.
Yuwen Wang, Songyun Zou, +3 authors, Shi Xu.
Cell Biol Int, 2020 Apr 14; 44(8). PMID: 32281704    Free PMC article.
Review.
FastClone is a probabilistic tool for deconvoluting tumor heterogeneity in bulk-sequencing samples.
Yao Xiao, Xueqing Wang, +3 authors, Yuanfang Guan.
Nat Commun, 2020 Sep 10; 11(1). PMID: 32901013    Free PMC article.
Inhibition of nicotinamide phosphoribosyltransferase (NAMPT) with OT-82 induces DNA damage, cell death, and suppression of tumor growth in preclinical models of Ewing sarcoma.
Anna E Gibson, Choh Yeung, +6 authors, Christine M Heske.
Oncogenesis, 2020 Sep 11; 9(9). PMID: 32908120    Free PMC article.
Collagen promotes anti-PD-1/PD-L1 resistance in cancer through LAIR1-dependent CD8+ T cell exhaustion.
David H Peng, Bertha Leticia Rodriguez, +13 authors, Don L Gibbons.
Nat Commun, 2020 Sep 11; 11(1). PMID: 32908154    Free PMC article.
An algorithm to quantify intratumor heterogeneity based on alterations of gene expression profiles.
Mengyuan Li, Zhilan Zhang, Lin Li, Xiaosheng Wang.
Commun Biol, 2020 Sep 13; 3(1). PMID: 32917965    Free PMC article.
mTOR-mediated cancer drug resistance suppresses autophagy and generates a druggable metabolic vulnerability.
Niklas Gremke, Pierfrancesco Polo, +9 authors, Thorsten Stiewe.
Nat Commun, 2020 Sep 19; 11(1). PMID: 32943635    Free PMC article.
CRISPR/Cas9: A powerful genome editing technique for the treatment of cancer cells with present challenges and future directions.
Abu Hazafa, Muhammad Mumtaz, +8 authors, Fatima Zafar.
Life Sci, 2020 Oct 09; 263. PMID: 33031826    Free PMC article.
Review.
Modeling How Heterogeneity in Cell Cycle Length Affects Cancer Cell Growth Dynamics in Response to Treatment.
Eleftheria Tzamali, Georgios Tzedakis, Vangelis Sakkalis.
Front Oncol, 2020 Oct 13; 10. PMID: 33042800    Free PMC article.
137Cs γ Ray and 28Si Irradiation Induced Murine Hepatocellular Carcinoma Lipid Changes in Liver Assessed by MALDI-MSI Combined with Spatial Shrunken Centroid Clustering Algorithm: A Pilot Study.
Anna M Nia, Alexander Shavkunov, Robert L Ullrich, Mark R Emmett.
ACS Omega, 2020 Oct 13; 5(39). PMID: 33043195    Free PMC article.
Integration of Multiple Platforms for the Analysis of Multifluorescent Marking Technology Applied to Pediatric GBM and DIPG.
Giulia Pericoli, Stefania Petrini, +14 authors, Maria Vinci.
Int J Mol Sci, 2020 Sep 19; 21(18). PMID: 32942636    Free PMC article.
Exploring MRI based radiomics analysis of intratumoral spatial heterogeneity in locally advanced nasopharyngeal carcinoma treated with intensity modulated radiotherapy.
Farhan Akram, Ping En Koh, +8 authors, Kiattisa Sommat.
PLoS One, 2020 Oct 06; 15(10). PMID: 33017440    Free PMC article.
Sustained activation of notch signaling maintains tumor-initiating cells in a murine model of liposarcoma.
Pei-Chieh Tien, Menchus Quan, Shihuan Kuang.
Cancer Lett, 2020 Sep 01; 494. PMID: 32866607    Free PMC article.
Gut microbiota: a new player in regulating immune- and chemo-therapy efficacy.
Simone Anfossi, George A Calin.
Cancer Drug Resist, 2020 Oct 17; 3. PMID: 33062956    Free PMC article.
Does Pemetrexed Work in Targetable, Nonsquamous Non-Small-Cell Lung Cancer? A Narrative Review.
Jin-Yuan Shih, Akira Inoue, +2 authors, Sang-We Kim.
Cancers (Basel), 2020 Sep 23; 12(9). PMID: 32957736    Free PMC article.
Review.
Pharmacogenomics for immunotherapy and immune-related cardiotoxicity.
Jessica A Castrillon, Charis Eng, Feixiong Cheng.
Hum Mol Genet, 2020 Jul 06; 29(R2). PMID: 32620943    Free PMC article.
Cannabinoid Combination Induces Cytoplasmic Vacuolation in MCF-7 Breast Cancer Cells.
Recardia Schoeman, Natasha Beukes, Carminita Frost.
Molecules, 2020 Oct 18; 25(20). PMID: 33066359    Free PMC article.
Single-cell derived tumor organoids display diversity in HLA class I peptide presentation.
Laura C Demmers, Kai Kretzschmar, +11 authors, Wei Wu.
Nat Commun, 2020 Oct 23; 11(1). PMID: 33087703    Free PMC article.
The Tumor Microenvironment of Pancreatic Cancer.
Eva Karamitopoulou.
Cancers (Basel), 2020 Oct 25; 12(10). PMID: 33096881    Free PMC article.
Implementing a clinical cutting-edge and decision-making activity: an ethnographic teamwork approach to a molecular tumorboard.
Nathalie Bot, Mathias Waelli.
BMC Health Serv Res, 2020 Oct 09; 20(1). PMID: 33028316    Free PMC article.
Pancreatic Adenocarcinoma Invasiveness and the Tumor Microenvironment: From Biology to Clinical Trials.
Isabel Mejia, Sandhya Bodapati, Kathryn T Chen, Begoña Díaz.
Biomedicines, 2020 Oct 15; 8(10). PMID: 33050151    Free PMC article.
Review.
The Impact of Next Generation Sequencing in Cancer Research.
Katia Nones, Ann-Marie Patch.
Cancers (Basel), 2020 Oct 16; 12(10). PMID: 33053644    Free PMC article.
The CINs of Polo-Like Kinase 1 in Cancer.
Chelsea E Cunningham, Mackenzie J MacAuley, +3 authors, Franco J Vizeacoumar.
Cancers (Basel), 2020 Oct 18; 12(10). PMID: 33066048    Free PMC article.
Review.
Immunotoxin Screening System: A Rapid and Direct Approach to Obtain Functional Antibodies with Internalization Capacities.
Shusei Hamamichi, Takeshi Fukuhara, Nobutaka Hattori.
Toxins (Basel), 2020 Oct 21; 12(10). PMID: 33076544    Free PMC article.
Review.
A Novel Gene Underlies Bleomycin-Response Variation in Caenorhabditis elegans.
Shannon C Brady, Stefan Zdraljevic, +5 authors, Erik C Andersen.
Genetics, 2019 Jun 07; 212(4). PMID: 31171655    Free PMC article.
Efficacy of a novel double-controlled oncolytic adenovirus driven by the Ki67 core promoter and armed with IL-15 against glioblastoma cells.
Qing Zhang, Junwen Zhang, +3 authors, Fusheng Liu.
Cell Biosci, 2020 Nov 03; 10. PMID: 33133514    Free PMC article.
Reovirus: Friend and Foe.
Michael R Eledge, Marcelle Dina Zita, Karl W Boehme.
Curr Clin Microbiol Rep, 2019 Jan 01; 6(3). PMID: 33134034    Free PMC article.
Total Body PET: Why, How, What for?
Suleman Surti, Austin R Pantel, Joel S Karp.
IEEE Trans Radiat Plasma Med Sci, 2020 Nov 03; 4(3). PMID: 33134653    Free PMC article.
Glioblastoma cell differentiation trajectory predicts the immunotherapy response and overall survival of patients.
Zihao Wang, Xiaopeng Guo, +3 authors, Bing Xing.
Aging (Albany NY), 2020 Sep 22; 12(18). PMID: 32957084    Free PMC article.
Epigenomic State Transitions Characterize Tumor Progression in Mouse Lung Adenocarcinoma.
Lindsay M LaFave, Vinay K Kartha, +15 authors, Tyler Jacks.
Cancer Cell, 2020 Jul 25; 38(2). PMID: 32707078    Free PMC article.
Dual Targeting of Endothelial and Cancer Cells Potentiates In Vitro Nanobody-Targeted Photodynamic Therapy.
Vida Mashayekhi, Katerina T Xenaki, Paul M P van Bergen En Henegouwen, Sabrina Oliveira.
Cancers (Basel), 2020 Sep 27; 12(10). PMID: 32977602    Free PMC article.
Cole Relaxation Frequency as a Prognostic Parameter for Breast Cancer.
William D Gregory, Shahila Mehboob Christie, +3 authors, Wendy Mikkelson.
J Patient Cent Res Rev, 2020 Nov 10; 7(4). PMID: 33163555    Free PMC article.
Vimentin filaments drive migratory persistence in polyploidal cancer cells.
Botai Xuan, Deepraj Ghosh, +2 authors, Michelle R Dawson.
Proc Natl Acad Sci U S A, 2020 Oct 14; 117(43). PMID: 33046658    Free PMC article.
Prediction of clinically actionable genetic alterations from colorectal cancer histopathology images using deep learning.
Hyun-Jong Jang, Ahwon Lee, +2 authors, Sung Hak Lee.
World J Gastroenterol, 2020 Nov 13; 26(40). PMID: 33177794    Free PMC article.
CAR T Cell Therapy for Solid Tumors: Bright Future or Dark Reality?
Jessica Wagner, Elizabeth Wickman, Christopher DeRenzo, Stephen Gottschalk.
Mol Ther, 2020 Sep 27; 28(11). PMID: 32979309    Free PMC article.
Review.
Single-Cell Techniques and Deep Learning in Predicting Drug Response.
Zhenyu Wu, Patrick J Lawrence, +3 authors, Qin Ma.
Trends Pharmacol Sci, 2020 Nov 07; 41(12). PMID: 33153777    Free PMC article.
Review.
Cellular State Transformations Using Deep Learning for Precision Medicine Applications.
Colin Targonski, M Reed Bender, +4 authors, F Alex Feltus.
Patterns (N Y), 2020 Nov 19; 1(6). PMID: 33205131    Free PMC article.
What Is the Storage Effect, Why Should It Occur in Cancers, and How Can It Inform Cancer Therapy?
Anna K Miller, Joel S Brown, David Basanta, Nancy Huntly.
Cancer Control, 2020 Jul 30; 27(3). PMID: 32723185    Free PMC article.
Artesunate Inhibits Growth of Sunitinib-Resistant Renal Cell Carcinoma Cells through Cell Cycle Arrest and Induction of Ferroptosis.
Sascha D Markowitsch, Patricia Schupp, +6 authors, Eva Juengel.
Cancers (Basel), 2020 Oct 31; 12(11). PMID: 33121039    Free PMC article.
Targeting CREB in Cancer Therapy: A Key Candidate or One of Many? An Update.
Luigi Sapio, Alessia Salzillo, +3 authors, Silvio Naviglio.
Cancers (Basel), 2020 Nov 01; 12(11). PMID: 33126560    Free PMC article.
Review.
Plasma Predictive Features in Treating EGFR-Mutated Non-Small Cell Lung Cancer.
Christi M J Steendam, G D Marijn Veerman, +13 authors, Anne-Marie C Dingemans.
Cancers (Basel), 2020 Nov 04; 12(11). PMID: 33138052    Free PMC article.
Understanding Nanoparticle Toxicity to Direct a Safe-by-Design Approach in Cancer Nanomedicine.
Jossana A Damasco, Saisree Ravi, +2 authors, Marites P Melancon.
Nanomaterials (Basel), 2020 Nov 06; 10(11). PMID: 33147800    Free PMC article.
Review.
Breast Cancer Heterogeneity and Response to Novel Therapeutics.
Mariona Baliu-Piqué, Atanasio Pandiella, Alberto Ocana.
Cancers (Basel), 2020 Nov 11; 12(11). PMID: 33167363    Free PMC article.
Review.
Cancer Stem Cells and the Slow Cycling Phenotype: How to Cut the Gordian Knot Driving Resistance to Therapy in Melanoma.
Luigi Fattore, Rita Mancini, Gennaro Ciliberto.
Cancers (Basel), 2020 Nov 19; 12(11). PMID: 33202944    Free PMC article.
Improving existing analysis pipeline to identify and analyze cancer driver genes using multi-omics data.
Quang-Huy Nguyen, Duc-Hau Le.
Sci Rep, 2020 Nov 27; 10(1). PMID: 33239644    Free PMC article.
Evidence for context-dependent functions of KDM5B in prostate development and prostate cancer.
Bigang Liu, Rahul Kumar, +4 authors, Dean G Tang.
Oncotarget, 2020 Nov 28; 11(46). PMID: 33245716    Free PMC article.
Overview of precision oncology trials: challenges and opportunities.
Elena Fountzilas, Apostolia M Tsimberidou.
Expert Rev Clin Pharmacol, 2018 Jul 26; 11(8). PMID: 30044653    Free PMC article.
Review.
New mass spectrometry technologies contributing towards comprehensive and high throughput omics analyses of single cells.
Sneha P Couvillion, Ying Zhu, +7 authors, Thomas O Metz.
Analyst, 2018 Dec 07; 144(3). PMID: 30507980    Free PMC article.
Review.
Cancer biomarker discovery and translation: proteomics and beyond.
Ventzislava A Hristova, Daniel W Chan.
Expert Rev Proteomics, 2018 Dec 18; 16(2). PMID: 30556752    Free PMC article.
Endogenous DNA Double-Strand Breaks during DNA Transactions: Emerging Insights and Methods for Genome-Wide Profiling.
Britta A M Bouwman, Nicola Crosetto.
Genes (Basel), 2018 Dec 19; 9(12). PMID: 30558210    Free PMC article.
Review.
Brown Seaweed Egregia menziesii's Cytotoxic Activity against Brain Cancer Cell Lines.
Tatiana Olivares-Bañuelos, Anllely G Gutiérrez-Rodríguez, +8 authors, Rossana C Zepeda.
Molecules, 2019 Jan 16; 24(2). PMID: 30641974    Free PMC article.
Gene-Specific Intron Retention Serves as Molecular Signature that Distinguishes Melanoma from Non-Melanoma Cancer Cells in Greek Patients.
Aikaterini F Giannopoulou, Eumorphia G Konstantakou, +19 authors, Dimitrios J Stravopodis.
Int J Mol Sci, 2019 Feb 24; 20(4). PMID: 30795533    Free PMC article.
How many samples are needed to infer truly clonal mutations from heterogenous tumours?
Luka Opasic, Da Zhou, +2 authors, Arne Traulsen.
BMC Cancer, 2019 May 01; 19(1). PMID: 31035962    Free PMC article.
The combined efficacy of OTS964 and temozolomide for reducing the size of power-law coded heterogeneous glioma stem cell populations.
Michiya Sugimori, Yumiko Hayakawa, Ryoi Tamura, Satoshi Kuroda.
Oncotarget, 2019 May 02; 10(24). PMID: 31040930    Free PMC article.
The Role of Ubiquitination in Regulating Embryonic Stem Cell Maintenance and Cancer Development.
Dian Wang, Fan Bu, Weiwei Zhang.
Int J Mol Sci, 2019 Jun 04; 20(11). PMID: 31151253    Free PMC article.
Review.
AKR1C1 controls cisplatin-resistance in head and neck squamous cell carcinoma through cross-talk with the STAT1/3 signaling pathway.
Wei-Min Chang, Yu-Chan Chang, +3 authors, Michael Hsiao.
J Exp Clin Cancer Res, 2019 Jun 12; 38(1). PMID: 31182137    Free PMC article.
The Detection and Morphological Analysis of Circulating Tumor and Host Cells in Breast Cancer Xenograft Models.
Loredana Cleris, Maria Grazia Daidone, Emanuela Fina, Vera Cappelletti.
Cells, 2019 Jul 10; 8(7). PMID: 31284534    Free PMC article.
The cytotoxic effect and glucose uptake modulation of Baeckea frutescens on breast cancer cells.
S H Shahruzaman, M F Mustafa, +3 authors, S Maniam.
BMC Complement Altern Med, 2019 Aug 21; 19(1). PMID: 31426778    Free PMC article.
Deep learning suggests that gene expression is encoded in all parts of a co-evolving interacting gene regulatory structure.
Jan Zrimec, Christoph S Börlin, +7 authors, Aleksej Zelezniak.
Nat Commun, 2020 Dec 03; 11(1). PMID: 33262328    Free PMC article.
Vascular Heterogeneity With a Special Focus on the Hepatic Microenvironment.
Johannes Robert Fleischer, Chiara Angelina Jodszuweit, +2 authors, Lena-Christin Conradi.
Front Physiol, 2020 Dec 03; 11. PMID: 33262705    Free PMC article.
Review.
Investigating a novel multiplex proteomics technology for detection of changes in serum protein concentrations that may correlate to tumor burden.
Annie He Ren, Ioannis Prassas, +4 authors, Eleftherios P Diamandis.
F1000Res, 2020 Dec 08; 9. PMID: 33274048    Free PMC article.
Nonlinear Image Registration and Pixel Classification Pipeline for the Study of Tumor Heterogeneity Maps.
Laura Nicolás-Sáenz, Sara Guerrero-Aspizua, Javier Pascau, Arrate Muñoz-Barrutia.
Entropy (Basel), 2020 Dec 09; 22(9). PMID: 33286715    Free PMC article.
Anticancer Activity of Thymoquinone Cubic Phase Nanoparticles Against Human Breast Cancer: Formulation, Cytotoxicity and Subcellular Localization.
Mohammed M Mehanna, Rana Sarieddine, +2 authors, Hala Gali-Muhtasib.
Int J Nanomedicine, 2020 Dec 10; 15. PMID: 33293807    Free PMC article.
Nanomedicine-based drug delivery towards tumor biological and immunological microenvironment.
Jin Li, Diane J Burgess.
Acta Pharm Sin B, 2020 Dec 12; 10(11). PMID: 33304781    Free PMC article.
Review.
Comprehensive genomic landscape and precision therapeutic approach in biliary tract cancers.
Ryosuke Okamura, Razelle Kurzrock, +5 authors, Jason K Sicklick.
Int J Cancer, 2020 Jul 24; 148(3). PMID: 32700810    Free PMC article.
Development and validation of a CT-texture analysis nomogram for preoperatively differentiating thymic epithelial tumor histologic subtypes.
Caiyue Ren, Mingli Li, Yunyan Zhang, Shengjian Zhang.
Cancer Imaging, 2020 Dec 15; 20(1). PMID: 33308325    Free PMC article.
Identification of a 6-Gene Signature Associated with Resistance to Tyrosine Kinase Inhibitors: Prognosis for Clear Cell Renal Cell Carcinoma.
Qinke Li, Wenbo Yang, Maoqing Lu, Ronggui Zhang.
Med Sci Monit, 2020 Dec 10; 26. PMID: 33296352    Free PMC article.
Immunological impact of cell death signaling driven by radiation on the tumor microenvironment.
Maria Esperanza Rodriguez-Ruiz, Ilio Vitale, +2 authors, Lorenzo Galluzzi.
Nat Immunol, 2019 Dec 25; 21(2). PMID: 31873291
Review.
Comparative Analysis of Cell-Cell Contact Abundance in Ovarian Carcinoma Cells Cultured in Two- and Three-Dimensional In Vitro Models.
Olga M Kutova, Ludmila M Sencha, +4 authors, Irina V Balalaeva.
Biology (Basel), 2020 Dec 10; 9(12). PMID: 33291824    Free PMC article.
Interrupting Neuron-Tumor Interactions to Overcome Treatment Resistance.
Patrick J Hunt, Katherine E Kabotyanski, +3 authors, Moran Amit.
Cancers (Basel), 2020 Dec 17; 12(12). PMID: 33322770    Free PMC article.
Review.
Different Calculation Strategies Are Congruent in Determining Chemotherapy Resistance of Brain Tumors In Vitro.
Igor Fischer, Ann-Christin Nickel, +9 authors, Ulf Dietrich Kahlert.
Cells, 2020 Dec 19; 9(12). PMID: 33333810    Free PMC article.
Multi-parametric characterization of drug effects on cells.
Yael Paran, Yuvalal Liron, +3 authors, Zvi Kam.
F1000Res, 2021 Feb 04; 9. PMID: 33363713    Free PMC article.
TNFAIP8 drives metabolic reprogramming to promote prostate cancer cell proliferation.
Suryakant Niture, Minghui Lin, +6 authors, Deepak Kumar.
Int J Biochem Cell Biol, 2020 Nov 24; 130. PMID: 33227392    Free PMC article.
An Automated Organoid Platform with Inter-organoid Homogeneity and Inter-patient Heterogeneity.
Shengwei Jiang, Haoran Zhao, +12 authors, Shaohua Ma.
Cell Rep Med, 2020 Dec 31; 1(9). PMID: 33377132    Free PMC article.
Breast Cancer Organoids Model Patient-Specific Response to Drug Treatment.
Elena Campaner, Alessandro Zannini, +8 authors, Giannino Del Sal.
Cancers (Basel), 2020 Dec 30; 12(12). PMID: 33371412    Free PMC article.
Clinical implications of plasma ctDNA features and dynamics in gastric cancer treated with HER2-targeted therapies.
Cheng Zhang, Zuhua Chen, +9 authors, Lin Shen.
Clin Transl Med, 2020 Dec 31; 10(8). PMID: 33377634    Free PMC article.
An Immune Gene-Related Five-lncRNA Signature for to Predict Glioma Prognosis.
Xinzhuang Wang, Ming Gao, +11 authors, Shiguang Zhao.
Front Genet, 2021 Jan 05; 11. PMID: 33391355    Free PMC article.
Multifunctional microfluidic chip for cancer diagnosis and treatment.
Qiao-Ru Guo, Ling-Ling Zhang, +8 authors, Jian-Ye Zhang.
Nanotheranostics, 2021 Jan 05; 5(1). PMID: 33391976    Free PMC article.
Review.
Single-cell dissection of intratumoral heterogeneity and lineage diversity in metastatic gastric adenocarcinoma.
Ruiping Wang, Minghao Dang, +29 authors, Linghua Wang.
Nat Med, 2021 Jan 06; 27(1). PMID: 33398161    Free PMC article.
The role of the PIK3CA gene in the development and aging of the brain.
Shaozhen Xie, Jing Ni, +4 authors, Thomas M Roberts.
Sci Rep, 2021 Jan 13; 11(1). PMID: 33431926    Free PMC article.
Case report: 16-yr life history and genomic evolution of an ER+ HER2- breast cancer.
Bing Xu, Anu Amallraja, +10 authors, Tobias Meißner.
Cold Spring Harb Mol Case Stud, 2020 Oct 04; 6(6). PMID: 33008833    Free PMC article.
Tumor heterogeneity in muscle-invasive bladder cancer.
Ho Won Kang, Wun-Jae Kim, Woonyoung Choi, Seok Joong Yun.
Transl Androl Urol, 2021 Jan 19; 9(6). PMID: 33457261    Free PMC article.
Review.
Advances in the development of personalized neoantigen-based therapeutic cancer vaccines.
Eryn Blass, Patrick A Ott.
Nat Rev Clin Oncol, 2021 Jan 22; 18(4). PMID: 33473220    Free PMC article.
Review.
An overview of neuroblastoma cell lineage phenotypes and in vitro models.
Sheron Campos Cogo, Thatyanne Gradowski Farias da Costa do Nascimento, +4 authors, Selene Elifio-Esposito.
Exp Biol Med (Maywood), 2020 Aug 14; 245(18). PMID: 32787463    Free PMC article.
Review.
Ameliorative effect of recombinant human lactoferrin on the premature ovarian failure in rats after cyclophosphamide treatments.
Shubin Li, Mengnan Liu, +6 authors, Yanfeng Dai.
J Ovarian Res, 2021 Jan 23; 14(1). PMID: 33478578    Free PMC article.
The Emerging Role of Nerves and Glia in Colorectal Cancer.
Simone L Schonkeren, Meike S Thijssen, +2 authors, Veerle Melotte.
Cancers (Basel), 2021 Jan 21; 13(1). PMID: 33466373    Free PMC article.
Review.
Molecular Imaging of Immunity and Inflammation and Its Impact on Precision Medicine.
Moritz Wildgruber, Michel Eisenblätter.
Biomedicines, 2021 Jan 15; 9(1). PMID: 33440667    Free PMC article.
Tumorsphere Derivation and Treatment from Primary Tumor Cells Isolated from Mouse Rhabdomyosarcomas.
Francesca Boscolo Sesillo, Alessandra Sacco.
J Vis Exp, 2019 Oct 01; (151). PMID: 31566597    Free PMC article.
An Efficient and Easy-to-Use Network-Based Integrative Method of Multi-Omics Data for Cancer Genes Discovery.
Ting Wei, Botao Fa, +3 authors, Zhangsheng Yu.
Front Genet, 2021 Jan 26; 11. PMID: 33488678    Free PMC article.
Resistance to anaplastic lymphoma kinase inhibitors: knowing the enemy is half the battle won.
Fabrizio Tabbò, Maria Lucia Reale, Paolo Bironzo, Giorgio V Scagliotti.
Transl Lung Cancer Res, 2021 Jan 26; 9(6). PMID: 33489817    Free PMC article.
Review.
Integrating Liquid Biopsy and Radiomics to Monitor Clonal Heterogeneity of EGFR-Positive Non-Small Cell Lung Cancer.
Federico Cucchiara, Marzia Del Re, +9 authors, Romano Danesi.
Front Oncol, 2021 Jan 26; 10. PMID: 33489892    Free PMC article.
Drug combination and repurposing for cancer therapy: the example of breast cancer.
Ana Salomé Correia, Fátima Gärtner, Nuno Vale.
Heliyon, 2021 Jan 26; 7(1). PMID: 33490692    Free PMC article.
Review.
Brain tumors: Cancer stem-like cells interact with tumor microenvironment.
Hai-Long Liu, Ya-Nan Wang, Shi-Yu Feng.
World J Stem Cells, 2021 Jan 29; 12(12). PMID: 33505594    Free PMC article.
Review.
High heterogeneity undermines generalization of differential expression results in RNA-Seq analysis.
Weitong Cui, Huaru Xue, +3 authors, Qinglu Wang.
Hum Genomics, 2021 Jan 30; 15(1). PMID: 33509298    Free PMC article.
Control of replication stress and mitosis in colorectal cancer stem cells through the interplay of PARP1, MRE11 and RAD51.
Gwenola Manic, Martina Musella, +23 authors, Ilio Vitale.
Cell Death Differ, 2021 Feb 04;. PMID: 33531658
Single-Cell Transcriptomic Heterogeneity in Invasive Ductal and Lobular Breast Cancer Cells.
Fangyuan Chen, Kai Ding, +7 authors, Adrian V Lee.
Cancer Res, 2020 Nov 06; 81(2). PMID: 33148662    Free PMC article.
Mixed response and mechanisms of resistance to larotrectinib in metastatic carcinoma ex pleomorphic adenoma of the parotid harboring an NTRK2 fusion: A case report.
Magdalena Pircher, Hans Rudolf Briner, +4 authors, Thomas Winder.
Medicine (Baltimore), 2021 Feb 04; 100(4). PMID: 33530256    Free PMC article.
Heterogeneity in 2,6-Linked Sialic Acids Potentiates Invasion of Breast Cancer Epithelia.
Dharma Pally, Durjay Pramanik, +5 authors, Ramray Bhat.
ACS Cent Sci, 2021 Feb 04; 7(1). PMID: 33532574    Free PMC article.
Melanoma Single-Cell Biology in Experimental and Clinical Settings.
Hans Binder, Maria Schmidt, +2 authors, Manfred Kunz.
J Clin Med, 2021 Feb 05; 10(3). PMID: 33535416    Free PMC article.
Review.
Functional and genetic characterization of three cell lines derived from a single tumor of an Opisthorchis viverrini-associated cholangiocarcinoma patient.
Banchob Sripa, Wunchana Seubwai, +13 authors, Yaovalux Chamgramol.
Hum Cell, 2020 Mar 25; 33(3). PMID: 32207095
Comprehensive Characterization of Immunological Profiles and Clinical Significance in Hepatocellular Carcinoma.
Ping Tao, Liang Hong, +5 authors, Ruyi Xue.
Front Oncol, 2021 Feb 09; 10. PMID: 33552954    Free PMC article.
Intrinsic growth heterogeneity of mouse leukemia cells underlies differential susceptibility to a growth-inhibiting anticancer drug.
Akihisa Seita, Hidenori Nakaoka, Reiko Okura, Yuichi Wakamoto.
PLoS One, 2021 Feb 02; 16(2). PMID: 33524064    Free PMC article.
Intratumoral heterogeneity in cancer progression and response to immunotherapy.
Ilio Vitale, Efrat Shema, Sherene Loi, Lorenzo Galluzzi.
Nat Med, 2021 Feb 13; 27(2). PMID: 33574607
Review.
The long non-coding RNA GHSROS reprograms prostate cancer cell lines toward a more aggressive phenotype.
Patrick B Thomas, Penny Jeffery, +12 authors, Inge Seim.
PeerJ, 2021 Feb 16; 9. PMID: 33585078    Free PMC article.
Intracellular Ca2 + Imbalance Critically Contributes to Paraptosis.
Eunhee Kim, Dong Min Lee, +2 authors, Kyeong Sook Choi.
Front Cell Dev Biol, 2021 Feb 16; 8. PMID: 33585447    Free PMC article.
Review.
Image-based consensus molecular subtype (imCMS) classification of colorectal cancer using deep learning.
Korsuk Sirinukunwattana, Enric Domingo, +22 authors, S:CORT consortium.
Gut, 2020 Jul 22; 70(3). PMID: 32690604    Free PMC article.
Overcoming biological barriers to improve solid tumor immunotherapy.
Anvay Ukidve, Katharina Cu, +2 authors, Samir Mitragotri.
Drug Deliv Transl Res, 2021 Feb 22;. PMID: 33611770
Cancer recurrence and lethality are enabled by enhanced survival and reversible cell cycle arrest of polyaneuploid cells.
K J Pienta, E U Hammarlund, +2 authors, R M Axelrod.
Proc Natl Acad Sci U S A, 2021 Jan 29; 118(7). PMID: 33504594    Free PMC article.
Effects of Surface Protein Adsorption on the Distribution and Retention of Intratumorally Administered Gold Nanoparticles.
Rossana Terracciano, Aobo Zhang, +4 authors, Carly S Filgueira.
Pharmaceutics, 2021 Feb 11; 13(2). PMID: 33562434    Free PMC article.
Microfluidic Organoids-on-a-Chip: Quantum Leap in Cancer Research.
Fahriye Duzagac, Gloria Saorin, +2 authors, Flavio Rizzolio.
Cancers (Basel), 2021 Feb 14; 13(4). PMID: 33578886    Free PMC article.
Review.
Single-cell resolved imaging reveals intra-tumor heterogeneity in glycolysis, transitions between metabolic states, and their regulatory mechanisms.
Hiroshi Kondo, Colin D H Ratcliffe, +6 authors, Erik Sahai.
Cell Rep, 2021 Feb 18; 34(7). PMID: 33596424    Free PMC article.
Sequential and co-occurring DNA damage response genetic mutations impact survival in stage III colorectal cancer patients receiving adjuvant oxaliplatin-based chemotherapy.
Peng-Chan Lin, Yu-Min Yeh, +4 authors, Meng-Ru Shen.
BMC Cancer, 2021 Mar 04; 21(1). PMID: 33653301    Free PMC article.
The key roles of cancer stem cell-derived extracellular vesicles.
Chaoyue Su, Jianye Zhang, Yosef Yarden, Liwu Fu.
Signal Transduct Target Ther, 2021 Mar 09; 6(1). PMID: 33678805    Free PMC article.
Review.
Prognostic Significance of Gene Expression and DNA Methylation Markers in Circulating Tumor Cells and Paired Plasma Derived Exosomes in Metastatic Castration Resistant Prostate Cancer.
Martha Zavridou, Areti Strati, +3 authors, Evi Lianidou.
Cancers (Basel), 2021 Mar 07; 13(4). PMID: 33668490    Free PMC article.
Tumor Heterogeneity: A Great Barrier in the Age of Cancer Immunotherapy.
Nader El-Sayes, Alyssa Vito, Karen Mossman.
Cancers (Basel), 2021 Mar 07; 13(4). PMID: 33671881    Free PMC article.
Review.
Nanodrug Delivery Systems Modulate Tumor Vessels to Increase the Enhanced Permeability and Retention Effect.
Dong Huang, Lingna Sun, Leaf Huang, Yanzuo Chen.
J Pers Med, 2021 Mar 07; 11(2). PMID: 33672813    Free PMC article.
Review.
Antigenic Essence: Upgrade of Cellular Cancer Vaccines.
Petr G Lokhov, Elena E Balashova.
Cancers (Basel), 2021 Mar 07; 13(4). PMID: 33673325    Free PMC article.
Review.
Advances in Human Immune System Mouse Models for Personalized Treg-Based Immunotherapies.
Isabelle Serr, Maria Kral, Martin G Scherm, Carolin Daniel.
Front Immunol, 2021 Mar 09; 12. PMID: 33679808    Free PMC article.
Review.
Mitochondrial impairments in aetiopathology of multifactorial diseases: common origin but individual outcomes in context of 3P medicine.
Lenka Koklesova, Marek Samec, +5 authors, Olga Golunitschaja.
EPMA J, 2021 Mar 10;. PMID: 33686350    Free PMC article.
Review.
When Tissue is an Issue the Liquid Biopsy is Nonissue: A Review.
July Rodríguez, Jenny Avila, +8 authors, Andrés F Cardona.
Oncol Ther, 2021 Mar 11; 9(1). PMID: 33689160    Free PMC article.
Review.
Mutation analysis using cell-free DNA for endocrine therapy in patients with HR+ metastatic breast cancer.
Sung Hoon Sim, Han Na Yang, +2 authors, In Hae Park.
Sci Rep, 2021 Mar 12; 11(1). PMID: 33692409    Free PMC article.
Radiogenomics in Colorectal Cancer.
Bogdan Badic, Florent Tixier, +2 authors, Dimitris Visvikis.
Cancers (Basel), 2021 Mar 04; 13(5). PMID: 33652647    Free PMC article.
Review.
HIF-Prolyl Hydroxylase Domain Proteins (PHDs) in Cancer-Potential Targets for Anti-Tumor Therapy?
Diana Gaete, Diego Rodriguez, +3 authors, Ben Wielockx.
Cancers (Basel), 2021 Mar 07; 13(5). PMID: 33673417    Free PMC article.
Review.
Profiling of circulating tumor DNA and tumor tissue for treatment selection in patients with advanced and refractory carcinoma: a prospective, two-stage phase II Individualized Cancer Treatment trial.
Jakob M Riedl, Samantha O Hasenleithner, +13 authors, Armin Gerger.
Ther Adv Med Oncol, 2021 Mar 16; 13. PMID: 33717225    Free PMC article.
Leveraging Single-Cell Approaches in Cancer Precision Medicine.
Aritro Nath, Andrea H Bild.
Trends Cancer, 2021 Feb 11; 7(4). PMID: 33563578    Free PMC article.
Review.
Liquid Biopsy for Prognosis and Treatment in Metastatic Colorectal Cancer: Circulating Tumor Cells vs Circulating Tumor DNA.
Giorgio Patelli, Caterina Vaghi, +9 authors, Andrea Sartore-Bianchi.
Target Oncol, 2021 Mar 20; 16(3). PMID: 33738696    Free PMC article.
Review.
The epigenetic basis of cellular heterogeneity.
Benjamin Carter, Keji Zhao.
Nat Rev Genet, 2020 Nov 28; 22(4). PMID: 33244170
Review.
Single-cell RNA sequencing reveals that targeting HSP90 suppresses PDAC progression by restraining mitochondrial bioenergetics.
Li-Peng Hu, Kai-Xia Zhou, +16 authors, Qin Yang.
Oncogenesis, 2021 Mar 05; 10(3). PMID: 33658487    Free PMC article.
Lymphoma Heterogeneity Unraveled by Single-Cell Transcriptomics.
Loic Ysebaert, Anne Quillet-Mary, +3 authors, Jean-Jacques Fournié.
Front Immunol, 2021 Mar 19; 12. PMID: 33732232    Free PMC article.
Review.
Clinical perspectives for the use of total body PET/CT.
Ronan Abgral, David Bourhis, Pierre-Yves Salaun.
Eur J Nucl Med Mol Imaging, 2021 Mar 21; 48(6). PMID: 33742236
Cell differentiation trajectory predicts patient potential immunotherapy response and prognosis in gastric cancer.
Renshen Xiang, Yuping Rong, +3 authors, Tao Fu.
Aging (Albany NY), 2021 Feb 23; 13(4). PMID: 33612483    Free PMC article.
Revisiting the Relationship Between Alzheimer's Disease and Cancer With a circRNA Perspective.
Danze Chen, Shijia Hao, Jianzhen Xu.
Front Cell Dev Biol, 2021 Mar 30; 9. PMID: 33777952    Free PMC article.
Promises and challenges of adoptive T-cell therapies for solid tumours.
Matteo Morotti, Ashwag Albukhari, +18 authors, Ahmed A Ahmed.
Br J Cancer, 2021 Mar 31; 124(11). PMID: 33782566    Free PMC article.
Review.
Group phenotypic composition in cancer.
Jean-Pascal Capp, James DeGregori, +10 authors, Frédéric Thomas.
Elife, 2021 Mar 31; 10. PMID: 33784238    Free PMC article.
Towards in-vivo label-free detection of brain tumor margins with epi-illumination tomographic quantitative phase imaging.
Paloma Casteleiro Costa, Zhe Guang, +4 authors, Francisco E Robles.
Biomed Opt Express, 2021 Apr 03; 12(3). PMID: 33796377    Free PMC article.
Adriamycin-resistant cells are significantly less fit than adriamycin-sensitive cells in cervical cancer.
Min Qi, Lijuan Xie, Guihua Duan.
Open Life Sci, 2021 Apr 06; 16(1). PMID: 33817298    Free PMC article.
Molecular and functional extracellular vesicle analysis using nanopatterned microchips monitors tumor progression and metastasis.
Peng Zhang, Xiaoqing Wu, +4 authors, Yong Zeng.
Sci Transl Med, 2020 Jun 12; 12(547). PMID: 32522804    Free PMC article.
Mass spectrometry imaging to detect lipid biomarkers and disease signatures in cancer.
Matthias Holzlechner, Eliseo Eugenin, Brendan Prideaux.
Cancer Rep (Hoboken), 2020 Jul 31; 2(6). PMID: 32729258    Free PMC article.
Review.
The Role of Network Science in Glioblastoma.
Marta B Lopes, Eduarda P Martins, Susana Vinga, Bruno M Costa.
Cancers (Basel), 2021 Apr 04; 13(5). PMID: 33801334    Free PMC article.
Review.
Strategies for Cancer Treatment Based on Photonic Nanomedicine.
Sueli Aparecida de Oliveira, Roger Borges, +4 authors, Juliana Marchi.
Materials (Basel), 2021 Apr 04; 14(6). PMID: 33809479    Free PMC article.
Review.
Horizons in Veterinary Precision Oncology: Fundamentals of Cancer Genomics and Applications of Liquid Biopsy for the Detection, Characterization, and Management of Cancer in Dogs.
Jason Chibuk, Andi Flory, +16 authors, Daniel S Grosu.
Front Vet Sci, 2021 Apr 10; 8. PMID: 33834049    Free PMC article.
Review.
Modifications of Plasma Membrane Organization in Cancer Cells for Targeted Therapy.
Anna Choromańska, Agnieszka Chwiłkowska, +7 authors, Jolanta Saczko.
Molecules, 2021 Apr 04; 26(7). PMID: 33806009    Free PMC article.
Review.
USP24 promotes drug resistance during cancer therapy.
Shao-An Wang, Ming-Jer Young, +6 authors, Jan-Jong Hung.
Cell Death Differ, 2021 Apr 14;. PMID: 33846536
Molecular profiles of response to neoadjuvant chemoradiotherapy in oesophageal cancers to develop personalized treatment strategies.
Leonie K de Klerk, Ruben S A Goedegebuure, +14 authors, Sarah Derks.
Mol Oncol, 2021 Jan 29; 15(4). PMID: 33506581    Free PMC article.
Deficiency of Ku Induces Host Cell Exploitation in Human Cancer Cells.
Okay Saydam, Nurten Saydam.
Front Cell Dev Biol, 2021 Apr 16; 9. PMID: 33855027    Free PMC article.
High prevalence of clonal hematopoiesis-type genomic abnormalities in cell-free DNA in invasive gliomas after treatment.
Ryosuke Okamura, David E Piccioni, +5 authors, Razelle Kurzrock.
Int J Cancer, 2021 Jan 27; 148(11). PMID: 33497479    Free PMC article.
TACC3 is a prognostic biomarker for kidney renal clear cell carcinoma and correlates with immune cell infiltration and T cell exhaustion.
Xiaoyan Fan, Boyi Liu, Zhiyu Wang, Dongwei He.
Aging (Albany NY), 2021 Mar 14; 13(6). PMID: 33714201    Free PMC article.
Intratumor heterogeneity, microenvironment, and mechanisms of drug resistance in glioma recurrence and evolution.
Zhaoshi Bao, Yongzhi Wang, +4 authors, Tao Jiang.
Front Med, 2021 Apr 25;. PMID: 33893983
Review.
EGFR/FOXO3a/BIM signaling pathway determines chemosensitivity of BMP4-differentiated glioma stem cells to temozolomide.
Iwona Anna Ciechomska, Bartlomiej Gielniewski, +2 authors, Jakub Mieczkowski.
Exp Mol Med, 2020 Aug 14; 52(8). PMID: 32788653    Free PMC article.
Identification of the Roles of a Stemness Index Based on mRNA Expression in the Prognosis and Metabolic Reprograming of Pancreatic Ductal Adenocarcinoma.
Rong Tang, Xiaomeng Liu, +8 authors, Si Shi.
Front Oncol, 2021 Apr 30; 11. PMID: 33912458    Free PMC article.
The Prognostic Impact of HER2 Genetic and Protein Expression in Pancreatic Carcinoma-HER2 Protein and Gene in Pancreatic Cancer.
Song-Hee Han, Ki Hyun Ryu, Ah-Young Kwon.
Diagnostics (Basel), 2021 May 01; 11(4). PMID: 33916543    Free PMC article.
Next Generation Sequencing Technology in the Clinic and Its Challenges.
Lau K Vestergaard, Douglas N P Oliveira, Claus K Høgdall, Estrid V Høgdall.
Cancers (Basel), 2021 May 01; 13(8). PMID: 33916923    Free PMC article.
Review.
Higher Mutation Burden in High Proliferation Compartments of Heterogeneous Melanoma Tumors.
Tomasz M Grzywa, Agnieszka A Koppolu, +5 authors, Paweł K Włodarski.
Int J Mol Sci, 2021 May 01; 22(8). PMID: 33918692    Free PMC article.
Epigenome Chaos: Stochastic and Deterministic DNA Methylation Events Drive Cancer Evolution.
Giusi Russo, Alfonso Tramontano, +2 authors, Antonio Pezone.
Cancers (Basel), 2021 May 01; 13(8). PMID: 33918773    Free PMC article.
Review.
A novel Lnc408 maintains breast cancer stem cell stemness by recruiting SP3 to suppress CBY1 transcription and increasing nuclear β-catenin levels.
Siyang Wen, Yilu Qin, +11 authors, Gang Tu.
Cell Death Dis, 2021 May 03; 12(5). PMID: 33934099    Free PMC article.
Clinical Experience and Recent Advances in the Development of Listeria-Based Tumor Immunotherapies.
Mariam Oladejo, Yvonne Paterson, Laurence M Wood.
Front Immunol, 2021 May 04; 12. PMID: 33936058    Free PMC article.
Review.
Selective multiplexed enrichment for the detection and quantitation of low-fraction DNA variants via low-depth sequencing.
Ping Song, Sherry X Chen, +5 authors, David Yu Zhang.
Nat Biomed Eng, 2021 May 05;. PMID: 33941896
Chemokines orchestrate tumor cells and the microenvironment to achieve metastatic heterogeneity.
Sugandha Saxena, Rakesh K Singh.
Cancer Metastasis Rev, 2021 May 08;. PMID: 33959849
Review.
Machine learning based on clinico-biological features integrated 18F-FDG PET/CT radiomics for distinguishing squamous cell carcinoma from adenocarcinoma of lung.
Caiyue Ren, Jianping Zhang, +5 authors, Jingyi Cheng.
Eur J Nucl Med Mol Imaging, 2020 Oct 16; 48(5). PMID: 33057772    Free PMC article.
IFNβ1 secreted by breast cancer cells undergoing chemotherapy reprograms stromal fibroblasts to support tumour growth after treatment.
Ana Maia, Zuguang Gu, +4 authors, Stefan Wiemann.
Mol Oncol, 2021 Jan 22; 15(5). PMID: 33476079    Free PMC article.
Therapeutic and prognostic implications of NOTCH and MAPK signaling in bladder cancer.
Gerald B Schulz, Sefer Elezkurtaj, +6 authors, David Horst.
Cancer Sci, 2021 Mar 10; 112(5). PMID: 33686706    Free PMC article.
Comprehensive analysis of genomic and immunological profiles in Chinese and Western hepatocellular carcinoma populations.
Wei Li, Hong Wu, Xuewen Xu, Yange Zhang.
Aging (Albany NY), 2021 Apr 20; 13(8). PMID: 33867349    Free PMC article.
Clonal Architectures Predict Clinical Outcome in Gastric Adenocarcinoma Based on Genomic Variation, Tumor Evolution, and Heterogeneity.
Chenxia Ren, Cuiling Wu, +2 authors, Changqing Yang.
Cell Transplant, 2021 Apr 27; 30. PMID: 33900127    Free PMC article.
ctDNA-Based Liquid Biopsy of Cerebrospinal Fluid in Brain Cancer.
Laura Escudero, Francisco Martínez-Ricarte, Joan Seoane.
Cancers (Basel), 2021 May 01; 13(9). PMID: 33919036    Free PMC article.
Review.
Intratumoral Cellular Heterogeneity: Implications for Drug Resistance in Patients with Non-Small Cell Lung Cancer.
Vanesa Gregorc, Chiara Lazzari, +12 authors, Claudio Doglioni.
Cancers (Basel), 2021 May 01; 13(9). PMID: 33922215    Free PMC article.
Review.
Next-Generation Sequencing with Liquid Biopsies from Treatment-Naïve Non-Small Cell Lung Carcinoma Patients.
Paul Hofman.
Cancers (Basel), 2021 May 01; 13(9). PMID: 33922637    Free PMC article.
Review.
Long non-coding RNAs in brain tumors: roles and potential as therapeutic targets.
Sung-Hyun Kim, Key-Hwan Lim, Sumin Yang, Jae-Yeol Joo.
J Hematol Oncol, 2021 May 14; 14(1). PMID: 33980320    Free PMC article.
Review.
Informing the new developments and future of cancer immunotherapy : Future of cancer immunotherapy.
Atul Kumar, Courtney A Swain, Lalita A Shevde.
Cancer Metastasis Rev, 2021 May 19;. PMID: 34003425
Review.
A Dual pH-Responsive DOX-Encapsulated Liposome Combined with Glucose Administration Enhanced Therapeutic Efficacy of Chemotherapy for Cancer.
Luoping Zhai, Chuangwei Luo, +3 authors, Fan Wang.
Int J Nanomedicine, 2021 May 20; 16. PMID: 34007173    Free PMC article.
Deciphering Tumor Heterogeneity in Hepatocellular Carcinoma (HCC)-Multi-Omic and Singulomic Approaches.
Renumathy Dhanasekaran.
Semin Liver Dis, 2021 Mar 26; 41(1). PMID: 33764481    Free PMC article.
The miR-181a-SFRP4 Axis Regulates Wnt Activation to Drive Stemness and Platinum Resistance in Ovarian Cancer.
Anil Belur Nagaraj, Matthew Knarr, +10 authors, Analisa DiFeo.
Cancer Res, 2021 Feb 13; 81(8). PMID: 33574092    Free PMC article.
A combination of ssGSEA and mass cytometry identifies immune microenvironment in muscle-invasive bladder cancer.
Xi Wang, Lixin Pan, +10 authors, Tianyu Li.
J Clin Lab Anal, 2021 Apr 05; 35(5). PMID: 33813769    Free PMC article.
Establishment of Colorectal Cancer Organoids in Microfluidic-Based System.
Diana Pinho, Denis Santos, Ana Vila, Sandra Carvalho.
Micromachines (Basel), 2021 May 01; 12(5). PMID: 33924829    Free PMC article.
Basic and Preclinical Research for Personalized Medicine.
Wanda Lattanzi, Cristian Ripoli, +6 authors, Ornella Parolini.
J Pers Med, 2021 May 06; 11(5). PMID: 33946634    Free PMC article.
Review.
MesKit: a tool kit for dissecting cancer evolution of multi-region tumor biopsies through somatic alterations.
Mengni Liu, Jianyu Chen, +6 authors, Qi Zhao.
Gigascience, 2021 May 22; 10(5). PMID: 34018555    Free PMC article.
Molecular landscape and subtype-specific therapeutic response of nasopharyngeal carcinoma revealed by integrative pharmacogenomics.
Ren-Bo Ding, Ping Chen, +20 authors, Chu-Xia Deng.
Nat Commun, 2021 May 26; 12(1). PMID: 34031426    Free PMC article.
Multi-Site Tumour Sampling Improves the Detection of Intra-Tumour Heterogeneity in Oral and Oropharyngeal Squamous Cell Carcinoma.
Weiping Jie, Jiaying Bai, +2 authors, Bin-Bin Li.
Front Med (Lausanne), 2021 May 28; 8. PMID: 34041255    Free PMC article.
MET overexpression and intratumor heterogeneity in esophageal squamous cell carcinoma.
H S Abboud, D Camuzi, +7 authors, S C Soares-Lima.
Braz J Med Biol Res, 2021 May 27; 54(8). PMID: 34037097    Free PMC article.
GeromiRs Are Downregulated in the Tumor Microenvironment during Colon Cancer Colonization of the Liver in a Murine Metastasis Model.
Daniela Gerovska, Patricia Garcia-Gallastegi, +5 authors, Iker Badiola.
Int J Mol Sci, 2021 Jun 03; 22(9). PMID: 34062897    Free PMC article.
Exosomes and Cancer Stem Cells in Cancer Immunity: Current Reports and Future Directions.
Na-Kyeong Lee, Vinoth Kumar Kothandan, +2 authors, Seung-Rim Hwang.
Vaccines (Basel), 2021 Jun 03; 9(5). PMID: 34062950    Free PMC article.
Review.
A Potential Role for HUWE1 in Modulating Cisplatin Sensitivity.
Stijn Wenmaekers, Bastiaan J Viergever, +4 authors, Richard P Meijer.
Cells, 2021 Jun 03; 10(5). PMID: 34065298    Free PMC article.
Review.
Making Sense of Genetic Information: The Promising Evolution of Clinical Stratification and Precision Oncology Using Machine Learning.
Mahaly Baptiste, Sarah Shireen Moinuddeen, +2 authors, Gen Kaneko.
Genes (Basel), 2021 Jun 03; 12(5). PMID: 34065872    Free PMC article.
Review.
Metronomic Chemotherapy Modulates Clonal Interactions to Prevent Drug Resistance in Non-Small Cell Lung Cancer.
Maryna Bondarenko, Marion Le Grand, +8 authors, Nicolas André.
Cancers (Basel), 2021 Jun 03; 13(9). PMID: 34066944    Free PMC article.
Data-Driven Mathematical Model of Osteosarcoma.
Trang Le, Sumeyye Su, Arkadz Kirshtein, Leili Shahriyari.
Cancers (Basel), 2021 Jun 03; 13(10). PMID: 34068946    Free PMC article.
Rac1, A Potential Target for Tumor Therapy.
Jiaxin Liang, Linda Oyang, +12 authors, Qianjin Liao.
Front Oncol, 2021 Jun 04; 11. PMID: 34079763    Free PMC article.
Review.
Probing low-copy-number proteins in single living cells using single-cell plasmonic immunosandwich assays.
Jia Liu, Hui He, +2 authors, Zhen Liu.
Nat Protoc, 2021 Jun 06;. PMID: 34089021
Review.
PLAU Promotes Cell Proliferation and Epithelial-Mesenchymal Transition in Head and Neck Squamous Cell Carcinoma.
Guangjin Chen, Jiwei Sun, +3 authors, Lili Chen.
Front Genet, 2021 Jun 08; 12. PMID: 34093649    Free PMC article.