Journal Article
. 2017 Nov; 377(19):1836-1846.
doi: 10.1056/NEJMoa1701830.

20-Year Risks of Breast-Cancer Recurrence after Stopping Endocrine Therapy at 5 Years

Hongchao Pan 1 Richard Gray 1 Jeremy Braybrooke 1 Christina Davies 1 Carolyn Taylor 1 Paul McGale 1 Richard Peto 1 Kathleen I Pritchard 1 Jonas Bergh 1 Mitch Dowsett 1 Daniel F Hayes 1 EBCTCG  
Affiliations
  • PMID: 29117498
  •     35 References
  •     282 citations

Abstract

Background: The administration of endocrine therapy for 5 years substantially reduces recurrence rates during and after treatment in women with early-stage, estrogen-receptor (ER)-positive breast cancer. Extending such therapy beyond 5 years offers further protection but has additional side effects. Obtaining data on the absolute risk of subsequent distant recurrence if therapy stops at 5 years could help determine whether to extend treatment.

Methods: In this meta-analysis of the results of 88 trials involving 62,923 women with ER-positive breast cancer who were disease-free after 5 years of scheduled endocrine therapy, we used Kaplan-Meier and Cox regression analyses, stratified according to trial and treatment, to assess the associations of tumor diameter and nodal status (TN), tumor grade, and other factors with patients' outcomes during the period from 5 to 20 years.

Results: Breast-cancer recurrences occurred at a steady rate throughout the study period from 5 to 20 years. The risk of distant recurrence was strongly correlated with the original TN status. Among the patients with stage T1 disease, the risk of distant recurrence was 13% with no nodal involvement (T1N0), 20% with one to three nodes involved (T1N1-3), and 34% with four to nine nodes involved (T1N4-9); among those with stage T2 disease, the risks were 19% with T2N0, 26% with T2N1-3, and 41% with T2N4-9. The risk of death from breast cancer was similarly dependent on TN status, but the risk of contralateral breast cancer was not. Given the TN status, the factors of tumor grade (available in 43,590 patients) and Ki-67 status (available in 7692 patients), which are strongly correlated with each other, were of only moderate independent predictive value for distant recurrence, but the status regarding the progesterone receptor (in 54,115 patients) and human epidermal growth factor receptor type 2 (HER2) (in 15,418 patients in trials with no use of trastuzumab) was not predictive. During the study period from 5 to 20 years, the absolute risk of distant recurrence among patients with T1N0 breast cancer was 10% for low-grade disease, 13% for moderate-grade disease, and 17% for high-grade disease; the corresponding risks of any recurrence or a contralateral breast cancer were 17%, 22%, and 26%, respectively.

Conclusions: After 5 years of adjuvant endocrine therapy, breast-cancer recurrences continued to occur steadily throughout the study period from 5 to 20 years. The risk of distant recurrence was strongly correlated with the original TN status, with risks ranging from 10 to 41%, depending on TN status and tumor grade. (Funded by Cancer Research UK and others.).

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Automated volumetric radiomic analysis of breast cancer vascularization improves survival prediction in primary breast cancer.
Matthias Dietzel, Rüdiger Schulz-Wendtland, +7 authors, Pascal A T Baltzer.
Sci Rep, 2020 Mar 01; 10(1). PMID: 32111898    Free PMC article.
Association of Circulating Tumor Cells With Late Recurrence of Estrogen Receptor-Positive Breast Cancer: A Secondary Analysis of a Randomized Clinical Trial.
Joseph Sparano, Anne O'Neill, +5 authors, Kathy D Miller.
JAMA Oncol, 2018 Jul 29; 4(12). PMID: 30054636    Free PMC article.
Highly Cited.
Prognostic Value of the Progesterone Receptor by Subtype in Patients with Estrogen Receptor-Positive, HER-2 Negative Breast Cancer.
Kathleen Van Asten, Laurence Slembrouck, +16 authors, Patrick Neven.
Oncologist, 2018 Sep 02; 24(2). PMID: 30171067    Free PMC article.
Chemotherapy resistance and stemness in mitotically quiescent human breast cancer cells identified by fluorescent dye retention.
Lewis A Quayle, Penelope D Ottewell, Ingunn Holen.
Clin Exp Metastasis, 2018 Nov 01; 35(8). PMID: 30377878    Free PMC article.
Lymph node involvement: Positive about the role of the recurrence score in estrogen-driven breast cancer?
Kevin Kalinsky, Ruth M O'Regan.
Cancer, 2018 Nov 06; 125(2). PMID: 30387877    Free PMC article.
Adjuvant Letrozole and Tamoxifen Alone or Sequentially for Postmenopausal Women With Hormone Receptor-Positive Breast Cancer: Long-Term Follow-Up of the BIG 1-98 Trial.
Thomas Ruhstaller, Anita Giobbie-Hurder, +27 authors, members of the BIG 1-98 Collaborative Group and the International Breast Cancer Study Group.
J Clin Oncol, 2018 Nov 27; 37(2). PMID: 30475668    Free PMC article.
Molecular changes during extended neoadjuvant letrozole treatment of breast cancer: distinguishing acquired resistance from dormant tumours.
Cigdem Selli, Arran K Turnbull, +7 authors, Andrew H Sims.
Breast Cancer Res, 2019 Jan 09; 21(1). PMID: 30616553    Free PMC article.
Effects of Jaeumkanghwa-tang on tamoxifen responsiveness in preclinical ER+ breast cancer model.
Fabia De Oliveira Andrade, Wei Yu, +5 authors, Leena Hilakivi-Clarke.
Endocr Relat Cancer, 2019 Jan 15; 26(3). PMID: 30640711    Free PMC article.
Proliferative potential and resistance to immune checkpoint blockade in lung cancer patients.
Sarabjot Pabla, Jeffrey M Conroy, +43 authors, Carl Morrison.
J Immunother Cancer, 2019 Feb 03; 7(1). PMID: 30709424    Free PMC article.
Clinical validation of an immunohistochemistry-based CanAssist-Breast test for distant recurrence prediction in hormone receptor-positive breast cancer patients.
Manjiri M Bakre, Charusheila Ramkumar, +10 authors, Mark D Pegram.
Cancer Med, 2019 Mar 09; 8(4). PMID: 30848103    Free PMC article.
Validation study of MARCKSL1 as a prognostic factor in lymph node-negative breast cancer patients.
Nina Gran Egeland, Marie Austdal, +6 authors, Kristin Jonsdottir.
PLoS One, 2019 Mar 12; 14(3). PMID: 30856208    Free PMC article.
Dynamics of breast-cancer relapse reveal late-recurring ER-positive genomic subgroups.
Oscar M Rueda, Stephen-John Sammut, +21 authors, Christina Curtis.
Nature, 2019 Mar 15; 567(7748). PMID: 30867590    Free PMC article.
Highly Cited.
Dual TGFβ/BMP Pathway Inhibition Enables Expansion and Characterization of Multiple Epithelial Cell Types of the Normal and Cancerous Breast.
Mayuri Prasad, Brijesh Kumar, +5 authors, Harikrishna Nakshatri.
Mol Cancer Res, 2019 Apr 18; 17(7). PMID: 30992305    Free PMC article.
SREBP1 drives Keratin-80-dependent cytoskeletal changes and invasive behavior in endocrine-resistant ERα breast cancer.
Ylenia Perone, Aaron J Farrugia, +16 authors, Luca Magnani.
Nat Commun, 2019 May 11; 10(1). PMID: 31073170    Free PMC article.
Avoiding over- and undertreatment in patients with resected node-positive breast cancer with the use of gene expression signatures: are we there yet?
A Matikas, T Foukakis, S Swain, J Bergh.
Ann Oncol, 2019 May 28; 30(7). PMID: 31131397    Free PMC article.
Review.
Relationships between SNPs and prognosis of breast cancer and pathogenic mechanism.
Yaning He, Hui Liu, +2 authors, Suxia Luo.
Mol Genet Genomic Med, 2019 Jul 19; 7(9). PMID: 31317673    Free PMC article.
Single-cell transcriptomics reveals multi-step adaptations to endocrine therapy.
Sung Pil Hong, Thalia E Chan, +9 authors, Luca Magnani.
Nat Commun, 2019 Sep 04; 10(1). PMID: 31477698    Free PMC article.
Combined Inhibition of STAT3 and DNA Repair in Palbociclib-Resistant ER-Positive Breast Cancer.
Nicole M Kettner, Smruthi Vijayaraghavan, +19 authors, Khandan Keyomarsi.
Clin Cancer Res, 2019 Mar 15; 25(13). PMID: 30867218    Free PMC article.
Highly Cited.
Rationally Designed Ruthenium Complexes for Breast Cancer Therapy.
Golara Golbaghi, Annie Castonguay.
Molecules, 2020 Jan 16; 25(2). PMID: 31936496    Free PMC article.
Review.
High-Dose Chemotherapy With Hematopoietic Stem Cell Transplant in Patients With High-Risk Breast Cancer and 4 or More Involved Axillary Lymph Nodes: 20-Year Follow-up of a Phase 3 Randomized Clinical Trial.
Tessa G Steenbruggen, Lars C Steggink, +18 authors, Jourik A Gietema.
JAMA Oncol, 2020 Jan 31; 6(4). PMID: 31999296    Free PMC article.
Influence of Competing Risks on Estimates of Recurrence Risk and Breast Cancer-specific Mortality in Analyses of the Early Breast Cancer Trialists Collaborative Group.
Ramy R Saleh, Michelle B Nadler, +3 authors, Eitan Amir.
Sci Rep, 2020 Mar 07; 10(1). PMID: 32139756    Free PMC article.
IGF-1R pathway activation as putative biomarker for linsitinib therapy to revert tamoxifen resistance in ER-positive breast cancer.
Dinja T Kruger, Xanthippi Alexi, +7 authors, Sabine C Linn.
Int J Cancer, 2019 Sep 07; 146(8). PMID: 31490549    Free PMC article.
Cytokeratin 5 alters β-catenin dynamics in breast cancer cells.
Olivia McGinn, Ashley V Ward, +6 authors, Carol A Sartorius.
Oncogene, 2020 Jan 29; 39(12). PMID: 31988452    Free PMC article.
In vitro Models of Breast Cancer Metastatic Dormancy.
Marco Montagner, Erik Sahai.
Front Cell Dev Biol, 2020 Mar 21; 8. PMID: 32195244    Free PMC article.
Review.
Roles of Splicing Factors in Hormone-Related Cancer Progression.
Toshihiko Takeiwa, Yuichi Mitobe, +2 authors, Satoshi Inoue.
Int J Mol Sci, 2020 Feb 29; 21(5). PMID: 32106418    Free PMC article.
Review.
Implication of environmental estrogens on breast cancer treatment and progression.
Thomas L Gonzalez, James M Rae, Justin A Colacino.
Toxicology, 2019 Apr 04; 421. PMID: 30940549    Free PMC article.
Review.
Use of letrozole after aromatase inhibitor-based therapy in postmenopausal breast cancer (NRG Oncology/NSABP B-42): a randomised, double-blind, placebo-controlled, phase 3 trial.
Eleftherios P Mamounas, Hanna Bandos, +17 authors, Norman Wolmark.
Lancet Oncol, 2018 Dec 05; 20(1). PMID: 30509771    Free PMC article.
Cytoplasmic ERα and NFκB Promote Cell Survival in Mouse Mammary Cancer Cell Lines.
Emily Smart, Luis H Alejo, Jonna Frasor.
Horm Cancer, 2020 Feb 03; 11(2). PMID: 32008217    Free PMC article.
Connection between SOX7 Expression and Breast Cancer Prognosis.
Chun-Xin Qin, Xiao-Qing Yang, Zhi-Yong Zhan.
Med Sci Monit, 2020 Apr 03; 26. PMID: 32238796    Free PMC article.
Metastatic Latency, a Veiled Threat.
Kangsan Kim, Mauricio Marquez-Palencia, Srinivas Malladi.
Front Immunol, 2019 Aug 27; 10. PMID: 31447846    Free PMC article.
Review.
Gene Expression Profiling Tests for Early-Stage Invasive Breast Cancer: A Health Technology Assessment.
Ontario Health (Quality).
Ont Health Technol Assess Ser, 2020 Apr 15; 20(10). PMID: 32284770    Free PMC article.
Prognosis and cure of long-term cancer survivors: A population-based estimation.
Luigino Dal Maso, Chiara Panato, +27 authors, AIRTUM Working group.
Cancer Med, 2019 Jun 18; 8(9). PMID: 31207165    Free PMC article.
Breast Cancer: A Molecularly Heterogenous Disease Needing Subtype-Specific Treatments.
Ugo Testa, Germana Castelli, Elvira Pelosi.
Med Sci (Basel), 2020 Mar 27; 8(1). PMID: 32210163    Free PMC article.
Review.
Overcoming Endocrine Resistance in Breast Cancer.
Ariella B Hanker, Dhivya R Sudhan, Carlos L Arteaga.
Cancer Cell, 2020 Apr 15; 37(4). PMID: 32289273    Free PMC article.
Review.
Absolute Improvements in Freedom From Distant Recurrence to Tailor Adjuvant Endocrine Therapies for Premenopausal Women: Results From TEXT and SOFT.
Olivia Pagani, Prudence A Francis, +13 authors, SOFT and TEXT Investigators and International Breast Cancer Study Group.
J Clin Oncol, 2019 Oct 17; 38(12). PMID: 31618131    Free PMC article.
Twenty-five-Year Follow-up of a Prospective Randomized Trial Comparing Preoperative Versus Postoperative FLAC/Granulocyte Colony-Stimulating Factor Chemotherapy for Stage II Breast Cancer.
Parisa Malekzadeh, Kenneth Cowan, +6 authors, David N Danforth.
Am J Clin Oncol, 2020 Jan 31; 43(5). PMID: 32000167    Free PMC article.
The Role of Nicotinamide in Cancer Chemoprevention and Therapy.
Ilias P Nikas, Stavroula A Paschou, Han Suk Ryu.
Biomolecules, 2020 Apr 05; 10(3). PMID: 32245130    Free PMC article.
Review.
Toronto Workshop on Late Recurrence in Estrogen Receptor-Positive Breast Cancer: Part 1: Late Recurrence: Current Understanding, Clinical Considerations.
Ryan J O Dowling, Kevin Kalinsky, +29 authors, Pamela J Goodwin.
JNCI Cancer Spectr, 2020 Apr 28; 3(4). PMID: 32337479    Free PMC article.
Simulation Modeling to Extend Clinical Trials of Adjuvant Chemotherapy Guided by a 21-Gene Expression Assay in Early Breast Cancer.
Jinani Jayasekera, Joseph A Sparano, +5 authors, Jeanne Mandelblatt.
JNCI Cancer Spectr, 2020 Apr 28; 3(4). PMID: 32337487    Free PMC article.
Young Women with Breast Cancer: Fertility Preservation Options and Management of Pregnancy-Associated Breast Cancer.
Nikita M Shah, Dana M Scott, +4 authors, Jacqueline S Jeruss.
Ann Surg Oncol, 2019 Jan 27; 26(5). PMID: 30680478    Free PMC article.
Machine Learning techniques in breast cancer prognosis prediction: A primary evaluation.
Carlo Boeri, Corrado Chiappa, +4 authors, Francesca Rovera.
Cancer Med, 2020 Mar 11; 9(9). PMID: 32154669    Free PMC article.
Single-Cell Probe Force Studies to Identify Sox2 Overexpression-Promoted Cell Adhesion in MCF7 Breast Cancer Cells.
Jagoba Iturri, Andreas Weber, María dM Vivanco, José L Toca-Herrera.
Cells, 2020 Apr 16; 9(4). PMID: 32290242    Free PMC article.
Updated Survival Analysis after a Median Follow-up of 12 Years of an Anthracycline-Containing Adjuvant Prospective Multicentre, Randomised Phase III Trial on Dose-Dense Chemotherapy in Primary Node-Positive, High-Risk Breast Cancer Patients.
Mattea Reinisch, Oleg Gluz, +10 authors, Sherko Kümmel.
Breast Care (Basel), 2019 Jul 19; 14(3). PMID: 31316314    Free PMC article.
Comparison of diagnostic sensitivity of [18F]fluoroestradiol and [18F]fluorodeoxyglucose positron emission tomography/computed tomography for breast cancer recurrence in patients with a history of estrogen receptor-positive primary breast cancer.
Sun Young Chae, Hye Joo Son, +7 authors, Dae Hyuk Moon.
EJNMMI Res, 2020 May 26; 10(1). PMID: 32448947    Free PMC article.
Dose-dense adjuvant chemotherapy in early breast cancer patients: 15-year results of the Phase 3 Mammella InterGruppo (MIG)-1 study.
Eva Blondeaux, Matteo Lambertini, +14 authors, Lucia Del Mastro.
Br J Cancer, 2020 Apr 02; 122(11). PMID: 32231293    Free PMC article.
Surgical trauma-induced immunosuppression in cancer: Recent advances and the potential therapies.
Fan Tang, Yan Tie, Chongqi Tu, Xiawei Wei.
Clin Transl Med, 2020 Jun 09; 10(1). PMID: 32508035    Free PMC article.
Review.
Deregulation of ribosomal protein expression and translation promotes breast cancer metastasis.
Richard Y Ebright, Sooncheol Lee, +22 authors, Douglas S Micalizzi.
Science, 2020 Feb 08; 367(6485). PMID: 32029688    Free PMC article.
Exposure-response analysis of endoxifen serum concentrations in early-breast cancer.
Anabel Beatriz Sanchez-Spitman, Dirk-Jan A R Moes, +5 authors, Henk-Jan Guchelaar.
Cancer Chemother Pharmacol, 2020 May 30; 85(6). PMID: 32468081    Free PMC article.
Targeting STAT3 signaling using stabilised sulforaphane (SFX-01) inhibits endocrine resistant stem-like cells in ER-positive breast cancer.
Bruno M Simões, Angélica Santiago-Gómez, +16 authors, Robert B Clarke.
Oncogene, 2020 May 31; 39(25). PMID: 32472077    Free PMC article.
Switching Homes: How Cancer Moves to Bone.
Marco Ponzetti, Nadia Rucci.
Int J Mol Sci, 2020 Jun 13; 21(11). PMID: 32527062    Free PMC article.
Review.
90 YEARS OF PROGESTERONE: Steroid receptors as MAPK signaling sensors in breast cancer: let the fates decide.
Amy R Dwyer, Thu H Truong, Julie H Ostrander, Carol A Lange.
J Mol Endocrinol, 2020 Mar 27; 65(1). PMID: 32209723    Free PMC article.
Review.
The concordance of treatment decision guided by OncotypeDX and the PREDICT tool in real-world early-stage breast cancer.
Daniel A Goldstein, Chen Mayer, +5 authors, Hadar Goldvaser.
Cancer Med, 2020 May 07; 9(13). PMID: 32372569    Free PMC article.
Breast cancer: are long-term and intermittent endocrine therapies equally effective?
Jutta Engel, Gabriele Schubert-Fritschle, Rebecca Emeny, Dieter Hölzel.
J Cancer Res Clin Oncol, 2020 May 31; 146(8). PMID: 32472445    Free PMC article.
Review.
Multi-cancer analysis of clonality and the timing of systemic spread in paired primary tumors and metastases.
Zheng Hu, Zan Li, Zhicheng Ma, Christina Curtis.
Nat Genet, 2020 May 20; 52(7). PMID: 32424352    Free PMC article.
A Systematic Review of the Prevalence and Diagnostic Workup of PIK3CA Mutations in HR+/HER2- Metastatic Breast Cancer.
Elizabeth J Anderson, Lea E Mollon, +5 authors, Lisa E Davis.
Int J Breast Cancer, 2020 Jul 09; 2020. PMID: 32637176    Free PMC article.
Case 22-2020: A 62-Year-Old Woman with Early Breast Cancer during the Covid-19 Pandemic.
Laura M Spring, Michelle C Specht, +6 authors, Beverly Moy.
N Engl J Med, 2020 Jul 02; 383(3). PMID: 32610007    Free PMC article.
Current State of the Art in the Adjuvant Systemic Treatment of Premenopausal Patients With Early Breast Cancer.
Francesca Parisi, Maria Grazia Razeti, +7 authors, Matteo Lambertini.
Clin Med Insights Oncol, 2020 Jul 11; 14. PMID: 32647477    Free PMC article.
CDK 4/6 Inhibitors in Breast Cancer: Current Controversies and Future Directions.
Laura M Spring, Seth A Wander, Mark Zangardi, Aditya Bardia.
Curr Oncol Rep, 2019 Feb 27; 21(3). PMID: 30806829    Free PMC article.
Review.
Expression of epithelial-mesenchymal transition-related markers and phenotypes during breast cancer progression.
Charlotte Levin Tykjær Jørgensen, Carina Forsare, +5 authors, Lisa Rydén.
Breast Cancer Res Treat, 2020 Apr 18; 181(2). PMID: 32300922    Free PMC article.
Long Noncoding RNAs Involved in the Endocrine Therapy Resistance of Breast Cancer.
Toshihiko Takeiwa, Kazuhiro Ikeda, +2 authors, Satoshi Inoue.
Cancers (Basel), 2020 Jun 04; 12(6). PMID: 32486413    Free PMC article.
Review.
Willingness of women with early estrogen receptor-positive breast cancer to take adjuvant CDK4/6 inhibitors.
N J Lipton, J Jesin, +4 authors, K J Jerzak.
Curr Oncol, 2020 Jul 17; 27(3). PMID: 32669921    Free PMC article.
Management of hormone receptor-positive, HER2-negative early breast cancer.
Elaine M Walsh, Karen L Smith, Vered Stearns.
Semin Oncol, 2020 Jun 18; 47(4). PMID: 32546323    Free PMC article.
Review.
CinéBreast-factors influencing the time to first metastatic recurrence in breast cancer: Analysis of real-life data from the French ESME MBC database.
P Gougis, M Carton, +20 authors, C Le Tourneau.
Breast, 2019 Nov 02; 49. PMID: 31675683    Free PMC article.
Late effects of adjuvant chemotherapy adumbrate dormancy complexity in breast cancer.
Romano Demicheli, Christine Desmedt, +3 authors, Elia Biganzoli.
Breast, 2020 May 20; 52. PMID: 32428688    Free PMC article.
Assessment of Long-term Distant Recurrence-Free Survival Associated With Tamoxifen Therapy in Postmenopausal Patients With Luminal A or Luminal B Breast Cancer.
Nancy Y Yu, Adina Iftimi, +10 authors, Linda S Lindström.
JAMA Oncol, 2019 Aug 09; 5(9). PMID: 31393518    Free PMC article.
Genomic landscape of metastatic breast cancer identifies preferentially dysregulated pathways and targets.
Matt R Paul, Tien-Chi Pan, +15 authors, Lewis A Chodosh.
J Clin Invest, 2020 Jul 14; 130(8). PMID: 32657779    Free PMC article.
Prognostic value of neutrophil-to-lymphocyte ratio in human epidermal growth factor receptor 2-negative breast cancer patients who received neoadjuvant chemotherapy.
Soong June Bae, Yoon Jin Cha, +10 authors, Joon Jeong.
Sci Rep, 2020 Aug 06; 10(1). PMID: 32753659    Free PMC article.
Endocrine Resistance in Hormone Receptor Positive Breast Cancer-From Mechanism to Therapy.
Aradhana Rani, Justin Stebbing, Georgios Giamas, John Murphy.
Front Endocrinol (Lausanne), 2019 Jun 11; 10. PMID: 31178825    Free PMC article.
Highly Cited. Review.
Maternal obesity increases offspring's mammary cancer recurrence and impairs tumor immune response.
Xiyuan Zhang, Fabia de Oliveira Andrade, +5 authors, Leena Hilakivi-Clarke.
Endocr Relat Cancer, 2020 Jun 25; 27(9). PMID: 32580156    Free PMC article.
Increased Expression of Interleukin-1 Receptor Characterizes Anti-estrogen-Resistant ALDH+ Breast Cancer Stem Cells.
Aida Sarmiento-Castro, Eva Caamaño-Gutiérrez, +11 authors, Bruno M Simões.
Stem Cell Reports, 2020 Jul 25; 15(2). PMID: 32707076    Free PMC article.
Personalised medicine and the decision to withhold chemotherapy in early breast cancer with intermediate risk of recurrence - a systematic review and meta-analysis.
Susanna M Wallerstedt, Astrid Nilsson Ek, +3 authors, Barbro Linderholm.
Eur J Clin Pharmacol, 2020 Jun 07; 76(9). PMID: 32504183    Free PMC article.
Systematic Review.
Digital Image Analysis of Ki-67 Stained Tissue Microarrays and Recurrence in Tamoxifen-Treated Breast Cancer Patients.
Nina Gran Egeland, Kristin Jonsdottir, +7 authors, Emiel A M Janssen.
Clin Epidemiol, 2020 Aug 18; 12. PMID: 32801916    Free PMC article.
PEG3 mutation is associated with elevated tumor mutation burden and poor prognosis in breast cancer.
Min Zhang, Jin Zhang.
Biosci Rep, 2020 Jul 31; 40(8). PMID: 32729618    Free PMC article.
The quest for improving the management of breast cancer by functional imaging: The discovery and development of 16α-[18F]fluoroestradiol (FES), a PET radiotracer for the estrogen receptor, a historical review.
John A Katzenellenbogen.
Nucl Med Biol, 2020 Apr 02; 92. PMID: 32229068    Free PMC article.
Review.
Targeting disseminated estrogen-receptor-positive breast cancer cells in bone marrow.
Johanna M Buschhaus, Brock A Humphries, +7 authors, Gary D Luker.
Oncogene, 2020 Jul 18; 39(34). PMID: 32678295    Free PMC article.
Prognostic significance of residual nodal disease after neoadjuvant endocrine therapy for hormone receptor-positive breast cancer.
Olga Kantor, Stephanie Wong, +3 authors, Tari A King.
NPJ Breast Cancer, 2020 Aug 22; 6. PMID: 32821803    Free PMC article.
Metabolomic analysis of serum may refine 21-gene expression assay risk recurrence stratification.
Amelia McCartney, Alessia Vignoli, +6 authors, Angelo Di Leo.
NPJ Breast Cancer, 2019 Sep 05; 5. PMID: 31482106    Free PMC article.
Patient Characteristics Influence Activated Signal Transducer and Activator of Transcription 3 (STAT3) Levels in Primary Breast Cancer-Impact on Prognosis.
Linn Nilsson, Emma Sandén, +6 authors, Helena Jernström.
Front Oncol, 2020 Aug 28; 10. PMID: 32850390    Free PMC article.
Primary 21-Gene Recurrence Score and Disease Outcome in Loco-Regional and Distant Recurrent Breast Cancer Patients.
Yujie Lu, Yiwei Tong, +10 authors, Kunwei Shen.
Front Oncol, 2020 Aug 28; 10. PMID: 32850415    Free PMC article.
Cases in Precision Medicine: The Role of Tumor and Germline Genetic Testing in Breast Cancer Management.
Jonah Tischler, Katherine D Crew, Wendy K Chung.
Ann Intern Med, 2019 Oct 22; 171(12). PMID: 31634909    Free PMC article.
DAXX-inducing phytoestrogens inhibit ER+ tumor initiating cells and delay tumor development.
Daniel S Peiffer, Emily Ma, +2 authors, Clodia Osipo.
NPJ Breast Cancer, 2020 Aug 31; 6. PMID: 32864429    Free PMC article.
FGFR4 regulates tumor subtype differentiation in luminal breast cancer and metastatic disease.
Susana Garcia-Recio, Aatish Thennavan, +22 authors, Charles M Perou.
J Clin Invest, 2020 Jun 24; 130(9). PMID: 32573490    Free PMC article.
Long non-coding NR2F1-AS1 is associated with tumor recurrence in estrogen receptor-positive breast cancers.
Anna Sanchez Calle, Tomofumi Yamamoto, +8 authors, Yusuke Yamamoto.
Mol Oncol, 2020 May 12; 14(9). PMID: 32392629    Free PMC article.
Application of the ESMO-Magnitude of Clinical Benefit Scale (V.1.1) to the field of early breast cancer therapies.
Shani Paluch-Shimon, Nathan I Cherny, +4 authors, Fatima Cardoso.
ESMO Open, 2020 Sep 08; 5(5). PMID: 32893189    Free PMC article.
An Integrated Score and Nomogram Combining Clinical and Immunohistochemistry Factors to Predict High ISUP Grade Clear Cell Renal Cell Carcinoma.
Junlong Wu, Wen-Hao Xu, +3 authors, Ding-Wei Ye.
Front Oncol, 2019 Jan 09; 8. PMID: 30619768    Free PMC article.
Bone as a Preferential Site for Metastasis.
Miranda E Sowder, Rachelle W Johnson.
JBMR Plus, 2019 Mar 29; 3(3). PMID: 30918918    Free PMC article.
Review.
Effect of 21-gene recurrence score in decision-making for surgery in early stage breast cancer.
San-Gang Wu, Wen-Wen Zhang, +3 authors, Zhen-Yu He.
Onco Targets Ther, 2019 Apr 10; 12. PMID: 30962690    Free PMC article.
Combined Targeting of Estrogen Receptor Alpha and XPO1 Prevent Akt Activation, Remodel Metabolic Pathways and Induce Autophagy to Overcome Tamoxifen Resistance.
Eylem Kulkoyluoglu-Cotul, Brandi Patrice Smith, +12 authors, Zeynep Madak-Erdogan.
Cancers (Basel), 2019 Apr 17; 11(4). PMID: 30987380    Free PMC article.
Focus on Formononetin: Anticancer Potential and Molecular Targets.
Samantha Kah Ling Ong, Muthu K Shanmugam, +5 authors, Anupam Bishayee.
Cancers (Basel), 2019 May 06; 11(5). PMID: 31052435    Free PMC article.
Review.
(-)-Oleocanthal Prevents Breast Cancer Locoregional Recurrence After Primary Tumor Surgical Excision and Neoadjuvant Targeted Therapy in Orthotopic Nude Mouse Models.
Abu Bakar Siddique, Nehad M Ayoub, +3 authors, Khalid A El Sayed.
Cancers (Basel), 2019 May 11; 11(5). PMID: 31072015    Free PMC article.
The bone metastasis niche in breast cancer-potential overlap with the haematopoietic stem cell niche in vivo.
Gloria Allocca, Russell Hughes, +4 authors, Ingunn Holen.
J Bone Oncol, 2019 Jun 27; 17. PMID: 31236323    Free PMC article.
HER2-Positive Conversion in a Metastatic Liver Focus in Late Recurrent Breast Cancer.
Miyuki Kitahara, Yasuo Hozumi, +3 authors, Tatsuo Iijima.
Case Rep Oncol, 2019 Jul 20; 12(2). PMID: 31320870    Free PMC article.
Correlation of radiotherapy with prognosis of elderly patients with hormone receptor-positive breast cancer according to immunohistochemical subtyping.
Xiangcheng Zhi, Xiaonan Yang, +5 authors, Jin Zhang.
Chin J Cancer Res, 2019 Jul 30; 31(3). PMID: 31354216    Free PMC article.
CDK4/6 inhibitors in advanced breast cancer, what is beyond?
Amrallah A Mohammed, Hanaa Rashied, Fifi Mostafa Elsayed.
Oncol Rev, 2019 Aug 28; 13(2). PMID: 31452841    Free PMC article.
Characterization of circulating breast cancer cells with tumorigenic and metastatic capacity.
Claudia Koch, Andra Kuske, +28 authors, Klaus Pantel.
EMBO Mol Med, 2020 Jul 16; 12(9). PMID: 32667137    Free PMC article.
Endocrine Therapy in Early Breast Cancer.
Katja Krauss, Elmar Stickeler.
Breast Care (Basel), 2020 Sep 29; 15(4). PMID: 32982643    Free PMC article.
Review.
Update on the Role of NFκB in Promoting Aggressive Phenotypes of Estrogen Receptor-Positive Breast Cancer.
Emily Smart, Svetlana E Semina, Jonna Frasor.
Endocrinology, 2020 Sep 06; 161(10). PMID: 32887995    Free PMC article.
Review.
Individualized Chemotherapy Benefit Prediction by EndoPredict in Patients With Early Breast Cancer in an Indian Cohort.
S P Somashekhar, Shabber Zaveri, +4 authors, Charu Bahl.
JCO Glob Oncol, 2020 Sep 09; 6. PMID: 32897733    Free PMC article.
Do we still need breast cancer screening in the era of targeted therapies and precision medicine?
Rubina Manuela Trimboli, Paolo Giorgi Rossi, +4 authors, Francesco Sardanelli.
Insights Imaging, 2020 Sep 26; 11(1). PMID: 32975658    Free PMC article.
Review.
A Novel Prognostic Scoring System Integrating Gene Expressions and Clinicopathological Characteristics to Predict Very Early Relapse in Node-Negative Estrogen Receptor-Positive/HER2-Negative Breast Cancer.
Caijin Lin, Jiayi Wu, +8 authors, Li Zhu.
Front Oncol, 2020 Oct 13; 10. PMID: 33042787    Free PMC article.
Trends in Late Mortality Among Adolescent and Young Adult Cancer Survivors.
Chelsea Anderson, Hazel B Nichols.
J Natl Cancer Inst, 2020 Mar 04; 112(10). PMID: 32123906    Free PMC article.
A Systematic Review of Estimating Breast Cancer Recurrence at the Population Level With Administrative Data.
Hava Izci, Tim Tambuyzer, +8 authors, Patrick Neven.
J Natl Cancer Inst, 2020 Apr 08; 112(10). PMID: 32259259    Free PMC article.
Systematic Review.
The FTO/miR-181b-3p/ARL5B signaling pathway regulates cell migration and invasion in breast cancer.
Yuanyuan Xu, Shuang Ye, +7 authors, Tinghuai Wang.
Cancer Commun (Lond), 2020 Aug 18; 40(10). PMID: 32805088    Free PMC article.
Single-Cell NGS-Based Analysis of Copy Number Alterations Reveals New Insights in Circulating Tumor Cells Persistence in Early-Stage Breast Cancer.
Tania Rossi, Giulia Gallerani, +8 authors, Francesco Fabbri.
Cancers (Basel), 2020 Sep 06; 12(9). PMID: 32887501    Free PMC article.
Combined Targeting of Estrogen Receptor Alpha and Exportin 1 in Metastatic Breast Cancers.
Eylem Kulkoyluoglu Cotul, Qianying Zuo, +20 authors, Zeynep Madak-Erdogan.
Cancers (Basel), 2020 Aug 28; 12(9). PMID: 32847042    Free PMC article.
Survival in Cytologically Proven Node-Positive Breast Cancer Patients with Nodal Pathological Complete Response after Neoadjuvant Chemotherapy.
Hitoshi Inari, Natsuki Teruya, +7 authors, Shinji Ohno.
Cancers (Basel), 2020 Sep 19; 12(9). PMID: 32942650    Free PMC article.
Breast Cancer and Tamoxifen: A Nigerian Perspective to Effective Personalised Therapy.
Ayorinde Adehin, Martin Alexander Kennedy, +3 authors, Oluseye Oladotun Bolaji.
Breast Cancer (Dove Med Press), 2020 Oct 30; 12. PMID: 33116814    Free PMC article.
Review.
Validation of an Algorithm to Ascertain Late Breast Cancer Recurrence Using Danish Medical Registries.
Rikke Nørgaard Pedersen, Buket Öztürk, +4 authors, Deirdre P Cronin-Fenton.
Clin Epidemiol, 2020 Oct 30; 12. PMID: 33116902    Free PMC article.
Cost-effectiveness analyses demonstrate that observation is superior to sentinel lymph node biopsy for postmenopausal women with HR + breast cancer and negative axillary ultrasound.
Aubriana M McEvoy, Steven Poplack, +7 authors, William E Gillanders.
Breast Cancer Res Treat, 2020 Jul 12; 183(2). PMID: 32651755    Free PMC article.
Review.
Breast Cancer Cell Detection and Characterization from Breast Milk-Derived Cells.
Poornima Bhat-Nakshatri, Brijesh Kumar, +5 authors, Harikrishna Nakshatri.
Cancer Res, 2020 Sep 17; 80(21). PMID: 32934021    Free PMC article.
Time-Resolved Profiling Reveals ATF3 as a Novel Mediator of Endocrine Resistance in Breast Cancer.
Simone Borgoni, Emre Sofyalı, +11 authors, Stefan Wiemann.
Cancers (Basel), 2020 Oct 15; 12(10). PMID: 33050633    Free PMC article.
Sensitive Detection of Minimal Residual Disease in Patients Treated for Early-Stage Breast Cancer.
Heather A Parsons, Justin Rhoades, +39 authors, Viktor A Adalsteinsson.
Clin Cancer Res, 2020 Mar 15; 26(11). PMID: 32170028    Free PMC article.
Comparison of breast cancer prognostic tests CanAssist Breast and Oncotype DX.
Aditya K Sengupta, Aparna Gunda, +4 authors, Manjiri M Bakre.
Cancer Med, 2020 Oct 08; 9(21). PMID: 33027559    Free PMC article.
MYC Targets Scores Are Associated with Cancer Aggressiveness and Poor Survival in ER-Positive Primary and Metastatic Breast Cancer.
Amy Schulze, Masanori Oshi, Itaru Endo, Kazuaki Takabe.
Int J Mol Sci, 2020 Nov 05; 21(21). PMID: 33143224    Free PMC article.
Omitting radiotherapy is safe in breast cancer patients ≥ 70 years old after breast-conserving surgery without axillary lymph node operation.
Ying Zhong, Yali Xu, +10 authors, Qiang Sun.
Sci Rep, 2020 Nov 12; 10(1). PMID: 33173112    Free PMC article.
Capsaicin suppresses breast cancer cell viability by regulating the CDK8/PI3K/Akt/Wnt/β‑catenin signaling pathway.
Di Wu, Hongyao Jia, Zhiru Zhang, Sijie Li.
Mol Med Rep, 2020 Nov 12; 22(6). PMID: 33173974    Free PMC article.
HER2 positivity is not associated with adverse prognosis in high-risk estrogen receptor-positive early breast cancer patients treated with chemotherapy and trastuzumab.
Shuai Li, Jiayi Wu, +6 authors, Kunwei Shen.
Breast, 2020 Nov 10; 54. PMID: 33166784    Free PMC article.
Downregulation of 15-hydroxyprostaglandin dehydrogenase during acquired tamoxifen resistance and association with poor prognosis in ERα-positive breast cancer.
Milene Volpato, Michele Cummings, +9 authors, Valerie Speirs.
Explor Target Antitumor Ther, 2020 Nov 20; 1. PMID: 33210098    Free PMC article.
When Should Oncologists Use the Words Hope and Cure?
Belinda E Kiely, Martin R Stockler.
JNCI Cancer Spectr, 2020 Nov 24; 4(6). PMID: 33225210    Free PMC article.
Technical Advancements for Studying Immune Regulation of Disseminated Dormant Cancer Cells.
Luigi Ombrato, Marco Montagner.
Front Oncol, 2020 Dec 01; 10. PMID: 33251149    Free PMC article.
Review.
Mechanisms of resistance in estrogen receptor positive breast cancer: overcoming resistance to tamoxifen/aromatase inhibitors.
Jamie N Mills, Alex C Rutkovsky, Antonio Giordano.
Curr Opin Pharmacol, 2018 May 03; 41. PMID: 29719270    Free PMC article.
Review.
CDK4/6 inhibitors in breast cancer therapy: Current practice and future opportunities.
Filipa Lynce, Ayesha N Shajahan-Haq, Sandra M Swain.
Pharmacol Ther, 2018 Jun 23; 191. PMID: 29933034    Free PMC article.
Review.
G-Protein-Coupled Receptor 5 (LGR5) Overexpression Activates β-Catenin Signaling in Breast Cancer Cells via Protein Kinase A.
Zhishui Chen, Chengjun Xue.
Med Sci Monit Basic Res, 2019 Jan 22; 25. PMID: 30662060    Free PMC article.
Systemic treatment and radiotherapy, breast cancer subtypes, and survival after long-term clinical follow-up.
Sherry X Yang, Eric C Polley.
Breast Cancer Res Treat, 2019 Feb 13; 175(2). PMID: 30746635    Free PMC article.
Differential Involvement of Autophagy and Apoptosis in Response to Chemoendocrine and Endocrine Therapy in Breast Cancer: JBCRG-07TR.
Takayuki Ueno, Norikazu Masuda, +5 authors, Masakazu Toi.
Int J Mol Sci, 2019 Mar 01; 20(4). PMID: 30813476    Free PMC article.
Identification and clinical validation of a multigene assay that interrogates the biology of cancer stem cells and predicts metastasis in breast cancer: A retrospective consecutive study.
Salvatore Pece, Davide Disalvatore, +8 authors, Pier Paolo Di Fiore.
EBioMedicine, 2019 Mar 09; 42. PMID: 30846393    Free PMC article.
Adherence to quality breast cancer survivorship care in four Canadian provinces: a CanIMPACT retrospective cohort study.
Mary L McBride, Patti A Groome, +6 authors, CanIMPACT Team.
BMC Cancer, 2019 Jul 06; 19(1). PMID: 31272420    Free PMC article.
Cathepsin V suppresses GATA3 protein expression in luminal A breast cancer.
Naphannop Sereesongsaeng, Sara H McDowell, +2 authors, Roberta E Burden.
Breast Cancer Res, 2020 Dec 11; 22(1). PMID: 33298139    Free PMC article.
Wntless (Wls): A Prognostic Index for Progression and Patient Survival of Breast Cancer.
Dandan Zheng, Chengwei Jiang, +7 authors, Zhaoying Yang.
Onco Targets Ther, 2020 Dec 19; 13. PMID: 33335405    Free PMC article.
Development of a Prognostic Tool to Guide the Decision to Extend Adjuvant Aromatase Inhibitors for up to Ten Years in Postmenopausal Early Breast Cancer Patients.
Camille Moreau-Bachelard, Loïc Campion, +6 authors, Jean-Sébastien Frénel.
Cancers (Basel), 2020 Dec 17; 12(12). PMID: 33322473    Free PMC article.
Current Status of Circulating Tumor Cells, Circulating Tumor DNA, and Exosomes in Breast Cancer Liquid Biopsies.
Marta Tellez-Gabriel, Erik Knutsen, Maria Perander.
Int J Mol Sci, 2020 Dec 17; 21(24). PMID: 33322643    Free PMC article.
Review.
Tumour-infiltrating lymphocytes as a prognostic and tamoxifen predictive marker in premenopausal breast cancer: data from a randomised trial with long-term follow-up.
Christine Lundgren, Pär-Ola Bendahl, +6 authors, Lisa Rydén.
Breast Cancer Res, 2020 Dec 29; 22(1). PMID: 33357231    Free PMC article.
CDK 4/6 inhibitors mired in uncertainty in HR positive and HER2 negative early breast cancer.
Serena Di Cosimo, Luca Porcu, Fatima Cardoso.
Breast, 2020 Dec 23; 55. PMID: 33352521    Free PMC article.
Role of myeloid-derived suppressor cells in metastasis.
Kathryn Cole, Kristina Pravoverov, James E Talmadge.
Cancer Metastasis Rev, 2021 Jan 08; 40(2). PMID: 33411082
Review.
Prognostic and predictive parameters in breast pathology: a pathologist's primer.
Kimberly H Allison.
Mod Pathol, 2020 Nov 07; 34(Suppl 1). PMID: 33154551
Understanding ER+ Breast Cancer Dormancy Using Bioinspired Synthetic Matrices for Long-Term 3D Culture and Insights into Late Recurrence.
Elisa M Ovadia, Lina Pradhan, +8 authors, April M Kloxin.
Adv Biosyst, 2020 Jul 01; 4(9). PMID: 32603024    Free PMC article.
Case report: 16-yr life history and genomic evolution of an ER+ HER2- breast cancer.
Bing Xu, Anu Amallraja, +10 authors, Tobias Meißner.
Cold Spring Harb Mol Case Stud, 2020 Oct 04; 6(6). PMID: 33008833    Free PMC article.
A Case of Pulmonary Metastasis of Breast Cancer 23 Years after Surgery Accompanied with Non-Tuberculous Mycobacterium Infection.
Yuki Yabuuchi, Takayuki Nakagawa, +17 authors, Yuko Minami.
Case Rep Oncol, 2021 Jan 15; 13(3). PMID: 33442355    Free PMC article.
Long-Term Prognostication for 20 114 Women With Small and Node-Negative Breast Cancer (T1abN0).
David Jaraj, Jonas Höijer, +9 authors, Pettersson Andreas.
JNCI Cancer Spectr, 2021 Jan 15; 5(1). PMID: 33442658    Free PMC article.
The clinical usefulness of the CTS5 in the prediction of late distant recurrence in postmenopausal women with estrogen receptor-positive early breast cancer.
Wakako Tajiri, Hideki Ijichi, +8 authors, Eriko Tokunaga.
Breast Cancer, 2020 Jul 01; 28(1). PMID: 32601800    Free PMC article.
Liquid biopsy enters the clinic - implementation issues and future challenges.
Michail Ignatiadis, George W Sledge, Stefanie S Jeffrey.
Nat Rev Clin Oncol, 2021 Jan 22; 18(5). PMID: 33473219
Review.
Genistein Reduces the Risk of Local Mammary Cancer Recurrence and Ameliorates Alterations in the Gut Microbiota in the Offspring of Obese Dams.
Fabia de Oliveira Andrade, Fang Liu, +7 authors, Leena Hilakivi-Clarke.
Nutrients, 2021 Jan 15; 13(1). PMID: 33440675    Free PMC article.
Clinical implications of intrinsic molecular subtypes of breast cancer for sentinel node status.
Maria Rossing, Christina Bligaard Pedersen, +7 authors, Bent Ejlertsen.
Sci Rep, 2021 Jan 28; 11(1). PMID: 33500440    Free PMC article.
IQGAP3 Overexpression Correlates With Poor Prognosis and Radiation Therapy Resistance in Breast Cancer.
Xin Hua, Zhi-Qing Long, +3 authors, Wen-Wen Zhang.
Front Pharmacol, 2021 Feb 02; 11. PMID: 33519444    Free PMC article.
Sustained mTORC1 activity during palbociclib-induced growth arrest triggers senescence in ER+ breast cancer cells.
Reeja S Maskey, Fang Wang, +8 authors, Anthony Mazurek.
Cell Cycle, 2020 Dec 29; 20(1). PMID: 33356791    Free PMC article.
Cancer stem cells: Culprits in endocrine resistance and racial disparities in breast cancer outcomes.
Nicole Mavingire, Petreena Campbell, +4 authors, Eileen Brantley.
Cancer Lett, 2020 Dec 15; 500. PMID: 33309858    Free PMC article.
CD39+PD-1+CD8+ T cells mediate metastatic dormancy in breast cancer.
Paulino Tallón de Lara, Héctor Castañón, +13 authors, Maries van den Broek.
Nat Commun, 2021 Feb 05; 12(1). PMID: 33536445    Free PMC article.
Hormonal Regulation of Semaphorin 7a in ER+ Breast Cancer Drives Therapeutic Resistance.
Lyndsey S Crump, Garhett L Wyatt, +3 authors, Traci R Lyons.
Cancer Res, 2020 Oct 31; 81(1). PMID: 33122307    Free PMC article.
FGFR1 amplification or overexpression and hormonal resistance in luminal breast cancer: rationale for a triple blockade of ER, CDK4/6, and FGFR1.
Silvana Mouron, Luis Manso, +6 authors, Maria J Bueno.
Breast Cancer Res, 2021 Feb 14; 23(1). PMID: 33579347    Free PMC article.
Cancer progression and the invisible phase of metastatic colonization.
Christoph A Klein.
Nat Rev Cancer, 2020 Oct 08; 20(11). PMID: 33024261
Review.
Twenty-year risks of breast cancer-specific mortality for stage III breast cancer in the surveillance, epidemiology, and end results registry.
José P Leone, Bernardo A Leone, +7 authors, Nancy U Lin.
Breast Cancer Res Treat, 2021 Feb 17; 187(3). PMID: 33590387
An evaluation of palbociclib as a breast cancer treatment option: a current update.
Gregory T Gallanis, Ramon I Pericas, Anna T Riegel, Paula R Pohlmann.
Expert Opin Pharmacother, 2020 Nov 18; 22(3). PMID: 33198527    Free PMC article.
Analgesic efficacy and safety of erector spinae plane block in breast cancer surgery: a systematic review and meta-analysis.
Ying Zhang, Tieshuai Liu, +2 authors, Gang Chen.
BMC Anesthesiol, 2021 Feb 22; 21(1). PMID: 33610172    Free PMC article.
Neoadjuvant Endocrine Therapy in Breast Cancer Management: State of the Art.
Florence Lerebours, Luc Cabel, Jean-Yves Pierga.
Cancers (Basel), 2021 Mar 07; 13(4). PMID: 33670042    Free PMC article.
Review.
Molecular Biomarkers for Contemporary Therapies in Hormone Receptor-Positive Breast Cancer.
Allegra Freelander, Lauren J Brown, +4 authors, Elgene Lim.
Genes (Basel), 2021 Mar 07; 12(2). PMID: 33671468    Free PMC article.
Review.
Anti-EGFR VHH-armed death receptor ligand-engineered allogeneic stem cells have therapeutic efficacy in diverse brain metastatic breast cancers.
Yohei Kitamura, Nobuhiko Kanaya, +12 authors, Khalid Shah.
Sci Adv, 2021 Mar 05; 7(10). PMID: 33658202    Free PMC article.
Mutation analysis using cell-free DNA for endocrine therapy in patients with HR+ metastatic breast cancer.
Sung Hoon Sim, Han Na Yang, +2 authors, In Hae Park.
Sci Rep, 2021 Mar 12; 11(1). PMID: 33692409    Free PMC article.
Preclinical Models to Study Obesity and Breast Cancer in Females: Considerations, Caveats, and Tools.
Erin D Giles, Elizabeth A Wellberg.
J Mammary Gland Biol Neoplasia, 2020 Nov 05; 25(4). PMID: 33146844    Free PMC article.
Review.
Clinical validity of clinical treatment score 5 (CTS5) for estimating risk of late recurrence in unselected, non-trial patients with early oestrogen receptor-positive breast cancer.
Juliet Richman, Alistair Ring, Mitch Dowsett, Ivana Sestak.
Breast Cancer Res Treat, 2020 Nov 23; 186(1). PMID: 33222093    Free PMC article.
The Role of Chemotherapy in Patients With HER2-Negative Isolated Locoregional Recurrence of Breast Cancer: A Multicenter Retrospective Cohort Study.
Kyoungmin Lee, Sung Hoon Sim, +9 authors, In Hae Park.
Front Oncol, 2021 Mar 23; 11. PMID: 33747970    Free PMC article.
Bone marrow niches in the regulation of bone metastasis.
Fenfang Chen, Yujiao Han, Yibin Kang.
Br J Cancer, 2021 Mar 25; 124(12). PMID: 33758331    Free PMC article.
Review.
A Clinical Decision Support System for Predicting Invasive Breast Cancer Recurrence: Preliminary Results.
Raffaella Massafra, Agnese Latorre, +13 authors, Vito Lorusso.
Front Oncol, 2021 Mar 30; 11. PMID: 33777733    Free PMC article.
The multigene classifiers 95GC/42GC/155GC for precision medicine in ER-positive HER2-negative early breast cancer.
Yasuto Naoi, Ryo Tsunashima, Kenzo Shimazu, Shinzaburo Noguchi.
Cancer Sci, 2021 Feb 06; 112(4). PMID: 33544932    Free PMC article.
Review.
Metastasis-Initiating Cells and Ecosystems.
Joan Massagué, Karuna Ganesh.
Cancer Discov, 2021 Apr 04; 11(4). PMID: 33811127    Free PMC article.
Review.
Global costs, health benefits, and economic benefits of scaling up treatment and imaging modalities for survival of 11 cancers: a simulation-based analysis.
Zachary J Ward, Andrew M Scott, Hedvig Hricak, Rifat Atun.
Lancet Oncol, 2021 Mar 05; 22(3). PMID: 33662286    Free PMC article.
Endocrine Therapy-related Endocrinopathies-Biology, Prevalence and Implications for the Management of Breast Cancer.
Kristy A Brown, Eleni Andreopoulou, Panagiota Andreopoulou.
Oncol Hematol Rev, 2021 Apr 13; 16(1). PMID: 33841882    Free PMC article.
Novel approaches to target the microenvironment of bone metastasis.
Lorenz C Hofbauer, Aline Bozec, +3 authors, Klaus Pantel.
Nat Rev Clin Oncol, 2021 Apr 21; 18(8). PMID: 33875860
Review.
Exploration of Circulating Tumour Cell (CTC) Biology: A Paradigm Shift in Liquid Biopsy.
Anshika Chauhan, Rajandeep Kaur, Sushmita Ghoshal, Arnab Pal.
Indian J Clin Biochem, 2021 Apr 20; 36(2). PMID: 33867703    Free PMC article.
Review.
Drug Screening of Potential Multiple Target Inhibitors for Estrogen Receptor-α-positive Breast Cancer.
Yun-Hao Dai, Guan-Yu Chen, +3 authors, Yang-Chang Wu.
In Vivo, 2021 Feb 25; 35(2). PMID: 33622869    Free PMC article.
Long-term outcome of (neo)adjuvant zoledronic acid therapy in locally advanced breast cancer.
Andrew P Jallouk, Sriram Paravastu, Katherine Weilbaecher, Rebecca L Aft.
Breast Cancer Res Treat, 2021 Feb 17; 187(1). PMID: 33591469    Free PMC article.
Factors associated with late risks of breast cancer-specific mortality in the SEER registry.
José P Leone, Carlos T Vallejo, +8 authors, Nancy U Lin.
Breast Cancer Res Treat, 2021 Apr 25; 189(1). PMID: 33893907    Free PMC article.
The dormant cancer cell life cycle.
Tri Giang Phan, Peter I Croucher.
Nat Rev Cancer, 2020 Jun 04; 20(7). PMID: 32488200
Review.
Molecular Drivers of Oncotype DX, Prosigna, EndoPredict, and the Breast Cancer Index: A TransATAC Study.
Richard Buus, Ivana Sestak, +6 authors, Mitch Dowsett.
J Clin Oncol, 2020 Oct 28; 39(2). PMID: 33108242    Free PMC article.
Complete and Durable Response to Tamoxifen and Ovarian Ablation in the Treatment of Metastatic Breast Cancer.
Hikmat Abdel-Razeq, Mahmoud Abunasser, +2 authors, Jakub Khzouz.
Cureus, 2021 Apr 29; 13(3). PMID: 33907637    Free PMC article.
Changes in initiation of adjuvant endocrine therapy for breast cancer after state health reform.
Kirsten Y Eom, G J van Londen, +3 authors, Lindsay M Sabik.
BMC Cancer, 2021 May 03; 21(1). PMID: 33933027    Free PMC article.
Construction of a Novel Bispecific Antibody to Enhance Antitumor Activity against Lung Cancer.
Wei Yin, Junjie Zhu, +5 authors, Yang Yang.
Adv Mater, 2018 Oct 23; 30(51). PMID: 30345557    Free PMC article.
Lasofoxifene as a potential treatment for therapy-resistant ER-positive metastatic breast cancer.
Muriel Lainé, Sean W Fanning, +6 authors, Geoffrey L Greene.
Breast Cancer Res, 2021 May 14; 23(1). PMID: 33980285    Free PMC article.
Risk of recurrence among patients with HR-positive, HER2-negative, early breast cancer receiving adjuvant endocrine therapy: A systematic review and meta-analysis.
Elizabeth M Salvo, Abril Oliva Ramirez, +4 authors, Imtiaz A Samjoo.
Breast, 2021 Mar 08; 57. PMID: 33677313    Free PMC article.
Capecitabine as Maintenance Therapy for High-Risk, Resected Colorectal Cancer.
Miklos L Auber, Sijin Wen, Gerald Hobbs, Gerald M Higa.
Gastrointest Tumors, 2021 May 14; 8(2). PMID: 33981686    Free PMC article.
Late Recurrence in Breast Cancer: To Run after the Oxen or to Try to Close the Barn?
Romano Demicheli, Elia Biganzoli.
Cancers (Basel), 2021 May 01; 13(9). PMID: 33922205    Free PMC article.
Evaluation of circulating tumor cells as a prognostic biomarker for early recurrence in stage II-III breast cancer patients using CytoSorter® system: a retrospective study.
Lidan Jin, Wan-Hung Fan, +2 authors, Wenhe Zhao.
PeerJ, 2021 May 15; 9. PMID: 33987029    Free PMC article.
Intra-tumoural lipid composition and lymphovascular invasion in breast cancer via non-invasive magnetic resonance spectroscopy.
Sai Man Cheung, Ehab Husain, +3 authors, Jiabao He.
Eur Radiol, 2020 Dec 04; 31(6). PMID: 33270144    Free PMC article.
Myeloid derived suppressor cells and the release of micro-metastases from dormancy.
Saraswoti Khadge, Kathryn Cole, James E Talmadge.
Clin Exp Metastasis, 2021 May 21; 38(3). PMID: 34014424    Free PMC article.
Review.
The many faces of cancer evolution.
Giovanni Ciriello, Luca Magnani.
iScience, 2021 May 25; 24(5). PMID: 34027317    Free PMC article.
Review.
The risk of contralateral breast cancer: a SEER-based analysis.
Vasily Giannakeas, David W Lim, Steven A Narod.
Br J Cancer, 2021 May 28; 125(4). PMID: 34040177    Free PMC article.
Breast cancer dormancy: need for clinically relevant models to address current gaps in knowledge.
Grace G Bushnell, Abhijeet P Deshmukh, +6 authors, Max S Wicha.
NPJ Breast Cancer, 2021 May 30; 7(1). PMID: 34050189    Free PMC article.
Review.
A rude awakening from tumour cells.
Fatima Cardoso, Giuseppe Curigliano.
Nature, 2018 Feb 01; 554(7690). PMID: 32094835
Inhibition of Antiestrogen-Promoted Pro-Survival Autophagy and Tamoxifen Resistance in Breast Cancer through Vitamin D Receptor.
Ye Li, Katherine L Cook, +4 authors, Leena Hilakivi-Clarke.
Nutrients, 2021 Jun 03; 13(5). PMID: 34069442    Free PMC article.
Development and Characterization of Novel Endoxifen-Resistant Breast Cancer Cell Lines Highlight Numerous Differences from Tamoxifen-Resistant Models.
Calley J Jones, Malayannan Subramaniam, +4 authors, John R Hawse.
Mol Cancer Res, 2021 Feb 26; 19(6). PMID: 33627502    Free PMC article.
Pluripotent Stem Cells: Cancer Study, Therapy, and Vaccination.
Mojgan Barati, Maryam Akhondi, +5 authors, Seyedeh-Nafiseh Hassani.
Stem Cell Rev Rep, 2021 Jun 12;. PMID: 34115316    Free PMC article.
Review.
Estrogen Modulates Epithelial Breast Cancer Cell Mechanics and Cell-to-Cell Contacts.
Barbara Zbiral, Andreas Weber, +2 authors, José L Toca-Herrera.
Materials (Basel), 2021 Jun 03; 14(11). PMID: 34071397    Free PMC article.
Circulating Biomarkers of CDK4/6 Inhibitors Response in Hormone Receptor Positive and HER2 Negative Breast Cancer.
Ilenia Migliaccio, Angela Leo, +6 authors, Luca Malorni.
Cancers (Basel), 2021 Jun 03; 13(11). PMID: 34072070    Free PMC article.
Review.
Causal Attributions in Breast Cancer Patients Planning to Undergo Adjuvant Endocrine Therapy.
Seul Ki Park, Yul Ha Min, Minsun Lee, Sae Byul Lee.
Int J Environ Res Public Health, 2021 Jun 03; 18(11). PMID: 34073064    Free PMC article.
Does margin width impact breast cancer recurrence rates in women with breast conserving surgery for ductal carcinoma in situ?
Devon Livingston-Rosanoff, Amy Trentham-Dietz, +2 authors, Lee G Wilke.
Breast Cancer Res Treat, 2021 Jun 16; 189(2). PMID: 34129117
Comprehensive Review of Molecular Mechanisms and Clinical Features of Invasive Lobular Cancer.
Nikhil Pramod, Akanksha Nigam, +7 authors, Bhuvaneswari Ramaswamy.
Oncologist, 2021 Mar 01; 26(6). PMID: 33641217    Free PMC article.
Review.
Time-Programmed Delivery of Sorafenib and Anti-CD47 Antibody via a Double-Layer-Gel Matrix for Postsurgical Treatment of Breast Cancer.
Liping Huang, Yiyi Zhang, +6 authors, Liang Luo.
Nanomicro Lett, 2021 Jun 18; 13(1). PMID: 34138357    Free PMC article.
Gastric Metastasis of Breast Cancer Found on Routine Esophageal Variceal Screening.
Luke Johnson, Ryan Ford, Nathan Tofteland.
Kans J Med, 2021 Jun 29; 14. PMID: 34178249    Free PMC article.
The Mammary Tumor Microenvironment.
Colleen S Curran, Suzanne M Ponik.
Adv Exp Med Biol, 2020 Jan 01; 1296. PMID: 34185292
Extending Adjuvant Endocrine Therapy for 10 Years: A Mixed-Methods Analysis of Women's Decision Making in an Online Breast Cancer Forum.
Yolanda Eraso, Denes Stefler, +2 authors, Sidona Assefa.
Healthcare (Basel), 2021 Jul 03; 9(6). PMID: 34200326    Free PMC article.
TRIMming Down Hormone-Driven Cancers: The Biological Impact of TRIM Proteins on Tumor Development, Progression and Prognostication.
Eleonora Pauletto, Nils Eickhoff, +2 authors, Wilbert Zwart.
Cells, 2021 Jul 03; 10(6). PMID: 34208621    Free PMC article.
Review.
Epigenetic Upregulation of MAGE-A Isoforms Promotes Breast Cancer Cell Aggressiveness.
Chaeun Oh, Hwa-Ryeon Kim, +8 authors, Kyung Hyun Yoo.
Cancers (Basel), 2021 Jul 03; 13(13). PMID: 34202157    Free PMC article.
Validation of the Clinical Treatment Score Post-Five Years in Breast Cancer Patients for Predicting Late Distant Recurrence: A Single-Center Investigation in Korea.
Jun-Hee Lee, Se Kyung Lee, +5 authors, Jai Min Ryu.
Front Oncol, 2021 Jul 10; 11. PMID: 34239805    Free PMC article.
Collective metastasis: coordinating the multicellular voyage.
Emma Wrenn, Yin Huang, Kevin Cheung.
Clin Exp Metastasis, 2021 Jul 14; 38(4). PMID: 34254215    Free PMC article.
Review.
Assessment of 25-Year Survival of Women With Estrogen Receptor-Positive/ERBB2-Negative Breast Cancer Treated With and Without Tamoxifen Therapy: A Secondary Analysis of Data From the Stockholm Tamoxifen Randomized Clinical Trial.
Huma Dar, Annelie Johansson, +9 authors, Linda S Lindström.
JAMA Netw Open, 2021 Jul 01; 4(6). PMID: 34190995    Free PMC article.
Comparative survival analysis of multiparametric tests-when molecular tests disagree-A TEAM Pathology study.
John M S Bartlett, Jane Bayani, +14 authors, Daniel Rea.
NPJ Breast Cancer, 2021 Jul 10; 7(1). PMID: 34238931    Free PMC article.
The Signal Transducer IL6ST (gp130) as a Predictive and Prognostic Biomarker in Breast Cancer.
Carlos Martínez-Pérez, Jess Leung, +4 authors, Arran K Turnbull.
J Pers Med, 2021 Jul 03; 11(7). PMID: 34210062    Free PMC article.
Review.
Clinical outcomes and prognostic biomarkers among pregnant, post-partum and nulliparous women with breast cancer: a prospective cohort study.
Katarzyna J Jerzak, Nechama Lipton, +4 authors, Ellen Warner.
Breast Cancer Res Treat, 2021 Jul 29;. PMID: 34318391
Lack of prognostic impact of sentinel node micro-metastases in endocrine receptor-positive early breast cancer: results from a large multicenter cohort☆.
G Houvenaeghel, A de Nonneville, +15 authors, A Goncalves.
ESMO Open, 2021 May 14; 6(3). PMID: 33984674    Free PMC article.
Radiotherapy Delivered before CDK4/6 Inhibitors Mediates Superior Therapeutic Effects in ER+ Breast Cancer.
Giulia Petroni, Aitziber Buqué, +5 authors, Lorenzo Galluzzi.
Clin Cancer Res, 2021 Jan 27; 27(7). PMID: 33495311    Free PMC article.
Trastuzumab for early-stage, HER2-positive breast cancer: a meta-analysis of 13 864 women in seven randomised trials.
Early Breast Cancer Trialists’ Collaborative group (EBCTCG).
Lancet Oncol, 2021 Aug 03; 22(8). PMID: 34339645    Free PMC article.
From Micro to Long: Non-Coding RNAs in Tamoxifen Resistance of Breast Cancer Cells.
Jéssica Fernanda Barazetti, Tayana Shultz Jucoski, +7 authors, Jaqueline Carvalho de Oliveira.
Cancers (Basel), 2021 Aug 08; 13(15). PMID: 34359587    Free PMC article.
Review.
Endogenous and Therapeutic Estrogens: Maestro Conductors of the Microenvironment of ER+ Breast Cancers.
Linda A Schuler, Fern E Murdoch.
Cancers (Basel), 2021 Aug 08; 13(15). PMID: 34359625    Free PMC article.
Review.
Aromatase Inhibitor-Associated Musculoskeletal Syndrome: Understanding Mechanisms and Management.
Tara Hyder, Christopher C Marino, +2 authors, Adam M Brufsky.
Front Endocrinol (Lausanne), 2021 Aug 14; 12. PMID: 34385978    Free PMC article.
Review.
Evaluation of the ability of the Clinical Treatment Score at 5 years (CTS5) compared to other risk stratification methods to predict the response to an extended endocrine therapy in breast cancer patients.
Andrea Villasco, Francesca Accomasso, +3 authors, Nicoletta Biglia.
Breast Cancer, 2021 May 04; 28(5). PMID: 33939116    Free PMC article.
18F-fluorodeoxyglucose (FDG) PET or 18F-fluorothymidine (FLT) PET to assess early response to aromatase inhibitors (AI) in women with ER+ operable breast cancer in a window-of-opportunity study.
Perrin E Romine, Lanell M Peterson, +10 authors, Hannah M Linden.
Breast Cancer Res, 2021 Aug 25; 23(1). PMID: 34425871    Free PMC article.
Population-based recurrence rates among older women with HR-positive, HER2-negative early breast cancer: Clinical risk factors, frailty status, and differences by race.
Jifang Zhou, Jenilee Cueto, +7 authors, Ernest H Law.
Breast, 2021 Aug 23; 59. PMID: 34419726    Free PMC article.
Transcriptomic Profiling Reveals Novel Candidate Genes and Signalling Programs in Breast Cancer Quiescence and Dormancy.
Lewis A Quayle, Amy Spicer, Penelope D Ottewell, Ingunn Holen.
Cancers (Basel), 2021 Aug 28; 13(16). PMID: 34439077    Free PMC article.
Application of the 21-Gene Recurrence Score in Patients with Early HR-Positive/HER2-Negative Breast Cancer: Chemotherapy and Survival Rate According to Clinical Risk.
Soong June Bae, Sung Gwe Ahn, +5 authors, Joon Jeong.
Cancers (Basel), 2021 Aug 28; 13(16). PMID: 34439158    Free PMC article.
Human Papillomavirus in Breast Carcinogenesis: A Passenger, a Cofactor, or a Causal Agent?
Rancés Blanco, Diego Carrillo-Beltrán, +3 authors, Francisco Aguayo.
Biology (Basel), 2021 Aug 28; 10(8). PMID: 34440036    Free PMC article.
Review.
Prognostic Significance of O-GlcNAc and PKM2 in Hormone Receptor-Positive and HER2-Nonenriched Breast Cancer.
Wen-Ling Kuo, Lin-Lu Tseng, +13 authors, Wen-Ching Wang.
Diagnostics (Basel), 2021 Aug 28; 11(8). PMID: 34441396    Free PMC article.