Review
. 2017 Nov; 131(1):58-67.
doi: 10.1182/blood-2017-06-741033.

CTLA-4: a moving target in immunotherapy

Behzad Rowshanravan 1 Neil Halliday 1 David M Sansom 1 
Affiliations
  • PMID: 29118008
  •     135 References
  •     220 citations

Abstract

CD28 and CTLA-4 are members of a family of immunoglobulin-related receptors that are responsible for various aspects of T-cell immune regulation. The family includes CD28, CTLA-4, and ICOS as well as other proteins, including PD-1, BTLA, and TIGIT. These receptors have both stimulatory (CD28, ICOS) and inhibitory roles (CTLA-4, PD-1, BTLA, and TIGIT) in T-cell function. Increasingly, these pathways are targeted as part of immune modulatory strategies to treat cancers, referred to generically as immune checkpoint blockade, and conversely to treat autoimmunity and CTLA-4 deficiency. Here, we focus on the biology of the CD28/CTLA-4 pathway as a framework for understanding the impacts of therapeutic manipulation of this pathway.

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Leukemia, 2016 Jan 01; 30(5). PMID: 26719098    Free PMC article.
Tolerance is established in polyclonal CD4(+) T cells by distinct mechanisms, according to self-peptide expression patterns.
Deepali Malhotra, Jonathan L Linehan, +9 authors, Marc K Jenkins.
Nat Immunol, 2016 Jan 05; 17(2). PMID: 26726812    Free PMC article.
Highly Cited.
The extended phenotype of LPS-responsive beige-like anchor protein (LRBA) deficiency.
Laura Gámez-Díaz, Dietrich August, +19 authors, Bodo Grimbacher.
J Allergy Clin Immunol, 2016 Jan 16; 137(1). PMID: 26768763
Highly Cited.
Intestinal microbiome analyses identify melanoma patients at risk for checkpoint-blockade-induced colitis.
Krista Dubin, Margaret K Callahan, +9 authors, Jedd D Wolchok.
Nat Commun, 2016 Feb 03; 7. PMID: 26837003    Free PMC article.
Highly Cited.
Induction of autoimmune disease by deletion of CTLA-4 in mice in adulthood.
Katrin Klocke, Shimon Sakaguchi, Rikard Holmdahl, Kajsa Wing.
Proc Natl Acad Sci U S A, 2016 Apr 14; 113(17). PMID: 27071130    Free PMC article.
Highly Cited.
Interrupting CD28 costimulation before antigen rechallenge affects CD8(+) T-cell expansion and effector functions during secondary response in mice.
Monika Fröhlich, Tea Gogishvili, +2 authors, Thomas Hünig.
Eur J Immunol, 2016 Apr 29; 46(7). PMID: 27122236
Safety profiles of anti-CTLA-4 and anti-PD-1 antibodies alone and in combination.
Celine Boutros, Ahmad Tarhini, +14 authors, Caroline Robert.
Nat Rev Clin Oncol, 2016 May 05; 13(8). PMID: 27141885
Highly Cited. Review.
The rise and fall of the CD28 superagonist TGN1412 and its return as TAB08: a personal account.
Thomas Hünig.
FEBS J, 2016 May 19; 283(18). PMID: 27191544
CD28 Costimulation: From Mechanism to Therapy.
Jonathan H Esensten, Ynes A Helou, +2 authors, Jeffrey A Bluestone.
Immunity, 2016 May 19; 44(5). PMID: 27192564    Free PMC article.
Highly Cited. Review.
Clonal expansion of CD8 T cells in the systemic circulation precedes development of ipilimumab-induced toxicities.
Sumit K Subudhi, Ana Aparicio, +14 authors, Padmanee Sharma.
Proc Natl Acad Sci U S A, 2016 Oct 30; 113(42). PMID: 27698113    Free PMC article.
Highly Cited.
Fulminant Myocarditis with Combination Immune Checkpoint Blockade.
Douglas B Johnson, Justin M Balko, +29 authors, Javid J Moslehi.
N Engl J Med, 2016 Nov 03; 375(18). PMID: 27806233    Free PMC article.
Highly Cited.
Efficient Culture of Human Naive and Memory B Cells for Use as APCs.
Kuei-Ying Su, Akiko Watanabe, +2 authors, Masayuki Kuraoka.
J Immunol, 2016 Nov 07; 197(10). PMID: 27815447    Free PMC article.
Immune Toxicities Elicted by CTLA-4 Blockade in Cancer Patients Are Associated with Early Diversification of the T-cell Repertoire.
David Y Oh, Jason Cham, +5 authors, Lawrence Fong.
Cancer Res, 2016 Dec 30; 77(6). PMID: 28031229    Free PMC article.
Identifying functional defects in patients with immune dysregulation due to LRBA and CTLA-4 mutations.
Tie Zheng Hou, Nisha Verma, +17 authors, David M Sansom.
Blood, 2017 Feb 06; 129(11). PMID: 28159733    Free PMC article.
Structural basis for cancer immunotherapy by the first-in-class checkpoint inhibitor ipilimumab.
Udupi A Ramagopal, Weifeng Liu, +10 authors, Steven C Almo.
Proc Natl Acad Sci U S A, 2017 May 10; 114(21). PMID: 28484017    Free PMC article.
Lymphoproliferative disorders with early lethality in mice deficient in Ctla-4.
P Waterhouse, J M Penninger, +6 authors, T W Mak.
Science, 1995 Nov 10; 270(5238). PMID: 7481803
Highly Cited.
Loss of CTLA-4 leads to massive lymphoproliferation and fatal multiorgan tissue destruction, revealing a critical negative regulatory role of CTLA-4.
E A Tivol, F Borriello, +3 authors, A H Sharpe.
Immunity, 1995 Nov 01; 3(5). PMID: 7584144
Highly Cited.
CD28 costimulation can promote T cell survival by enhancing the expression of Bcl-XL.
L H Boise, A J Minn, +4 authors, C B Thompson.
Immunity, 1995 Jul 01; 3(1). PMID: 7621080
Highly Cited.
B7/BB1, the ligand for CD28, is expressed on repeatedly activated human T cells in vitro.
D M Sansom, N D Hall.
Eur J Immunol, 1993 Jan 01; 23(1). PMID: 7678229
B70 antigen is a second ligand for CTLA-4 and CD28.
M Azuma, D Ito, +4 authors, C Somoza.
Nature, 1993 Nov 04; 366(6450). PMID: 7694153
Highly Cited.
Enhancement of antitumor immunity by CTLA-4 blockade.
D R Leach, M F Krummel, J P Allison.
Science, 1996 Mar 22; 271(5256). PMID: 8596936
Highly Cited.
T cell activation determined by T cell receptor number and tunable thresholds.
A Viola, A Lanzavecchia.
Science, 1996 Jul 05; 273(5271). PMID: 8658175
Highly Cited.
Intracellular trafficking of CTLA-4 and focal localization towards sites of TCR engagement.
P S Linsley, J Bradshaw, +3 authors, R S Mittler.
Immunity, 1996 Jun 01; 4(6). PMID: 8673700
Highly Cited.
Duration of TCR stimulation determines costimulatory requirement of T cells.
T M Kündig, A Shahinian, +5 authors, P S Ohashi.
Immunity, 1996 Jul 01; 5(1). PMID: 8758893
B7-1 and B7-2 have overlapping, critical roles in immunoglobulin class switching and germinal center formation.
F Borriello, M P Sethna, +7 authors, A H Sharpe.
Immunity, 1997 Mar 01; 6(3). PMID: 9075931
Highly Cited.
Tyrosine phosphorylation controls internalization of CTLA-4 by regulating its interaction with clathrin-associated adaptor complex AP-2.
T Shiratori, S Miyatake, +4 authors, T Saito.
Immunity, 1997 May 01; 6(5). PMID: 9175836
Interaction of CTLA-4 with the clathrin-associated protein AP50 results in ligand-independent endocytosis that limits cell surface expression.
E Chuang, M L Alegre, +3 authors, C B Thompson.
J Immunol, 1997 Jul 01; 159(1). PMID: 9200449
Interaction of CTLA-4 with AP50, a clathrin-coated pit adaptor protein.
Y Zhang, J P Allison.
Proc Natl Acad Sci U S A, 1997 Aug 19; 94(17). PMID: 9256472    Free PMC article.
The emerging role of CTLA-4 as an immune attenuator.
C B Thompson, J P Allison.
Immunity, 1997 Nov 14; 7(4). PMID: 9354465
Highly Cited. Review.
Studies using antigen-presenting cells lacking expression of both B7-1 (CD80) and B7-2 (CD86) show distinct requirements for B7 molecules during priming versus restimulation of Th2 but not Th1 cytokine production.
A N Schweitzer, A H Sharpe.
J Immunol, 1998 Sep 22; 161(6). PMID: 9743334
Molecular basis of T cell inactivation by CTLA-4.
K M Lee, E Chuang, +7 authors, J A Bluestone.
Science, 1998 Dec 18; 282(5397). PMID: 9856951
Highly Cited.
Gut microbiome modulates efficacy of immune checkpoint inhibitors.
Ming Yi, Shengnan Yu, +5 authors, Kongming Wu.
J Hematol Oncol, 2018 Mar 28; 11(1). PMID: 29580257    Free PMC article.
Highly Cited. Review.
Emergence of immunotherapy as a novel way to treat hepatocellular carcinoma.
Naofumi Mukaida, Yasunari Nakamoto.
World J Gastroenterol, 2018 May 10; 24(17). PMID: 29740200    Free PMC article.
Review.
The role of proteomics in the age of immunotherapies.
Sarah A Hayes, Stephen Clarke, Nick Pavlakis, Viive M Howell.
Mamm Genome, 2018 Jul 27; 29(11-12). PMID: 30046851
Review.
Not All Immune Checkpoints Are Created Equal.
Annika De Sousa Linhares, Judith Leitner, Katharina Grabmeier-Pfistershammer, Peter Steinberger.
Front Immunol, 2018 Sep 21; 9. PMID: 30233564    Free PMC article.
Highly Cited. Review.
Combination of immune checkpoint blockade with DNA cancer vaccine induces potent antitumor immunity against P815 mastocytoma.
Alessandra Lopes, Kevin Vanvarenberg, +5 authors, Gaëlle Vandermeulen.
Sci Rep, 2018 Oct 26; 8(1). PMID: 30356111    Free PMC article.
The alveolar immune cell landscape is dysregulated in checkpoint inhibitor pneumonitis.
Karthik Suresh, Jarushka Naidoo, +25 authors, Franco D'Alessio.
J Clin Invest, 2019 Jul 17; 129(10). PMID: 31310589    Free PMC article.
CD103+ tumor-infiltrating lymphocytes predict favorable prognosis in patients with esophageal squamous cell carcinoma.
Yifan Chu, Jing Liao, +8 authors, Lian Li.
J Cancer, 2019 Oct 12; 10(21). PMID: 31602274    Free PMC article.
Immunopathogenesis of Immune Checkpoint Inhibitor-Related Adverse Events: Roles of the Intestinal Microbiome and Th17 Cells.
Ronald Anderson, Annette J Theron, Bernardo L Rapoport.
Front Immunol, 2019 Oct 17; 10. PMID: 31616428    Free PMC article.
Review.
The efficacy and safety of combination of PD-1 and CTLA-4 inhibitors: a meta-analysis.
Kongju Wu, Ming Yi, +3 authors, Kongming Wu.
Exp Hematol Oncol, 2019 Nov 02; 8. PMID: 31673481    Free PMC article.
Review.
Delivery strategies of cancer immunotherapy: recent advances and future perspectives.
Zhongwei Zhao, Liyun Zheng, +3 authors, Jiansong Ji.
J Hematol Oncol, 2019 Nov 30; 12(1). PMID: 31779642    Free PMC article.
Review.
Immune Checkpoints in Circulating and Tumor-Infiltrating CD4+ T Cell Subsets in Colorectal Cancer Patients.
Salman M Toor, Khaled Murshed, +3 authors, Eyad Elkord.
Front Immunol, 2020 Jan 11; 10. PMID: 31921188    Free PMC article.
Immune Checkpoint Inhibitor-Induced Pancreatic Injury: Imaging Findings and Literature Review.
Michele Porcu, Cinzia Solinas, +6 authors, Luca Saba.
Target Oncol, 2020 Jan 12; 15(1). PMID: 31925647
Review.
A functional antibody cross-reactive to both human and murine cytotoxic T-lymphocyte-associated protein 4 via binding to an N-glycosylation epitope.
Dong Li, Jing Li, Huanyu Chu, Zhuozhi Wang.
MAbs, 2020 Feb 15; 12(1). PMID: 32054416    Free PMC article.
Biomaterials for vaccine-based cancer immunotherapy.
Rui Zhang, Margaret M Billingsley, Michael J Mitchell.
J Control Release, 2018 Oct 13; 292. PMID: 30312721    Free PMC article.
Review.
Nanomaterial-Based Modulation of Tumor Microenvironments for Enhancing Chemo/Immunotherapy.
Quoc-Viet Le, Juhan Suh, Yu-Kyoung Oh.
AAPS J, 2019 May 19; 21(4). PMID: 31102154
Review.
Phosphoinositide 3-kinase δ is a regulatory T-cell target in cancer immunotherapy.
Ee Lyn Lim, Klaus Okkenhaug.
Immunology, 2019 May 21; 157(3). PMID: 31107985    Free PMC article.
Review.
Potential immune escape mechanisms underlying the distinct clinical outcome of immune checkpoint blockades in small cell lung cancer.
Yaru Tian, Xiaoyang Zhai, +2 authors, Jinming Yu.
J Hematol Oncol, 2019 Jun 30; 12(1). PMID: 31253167    Free PMC article.
Review.
Molecular evolution of peptides by yeast surface display technology.
Sara Linciano, Stefano Pluda, Arianna Bacchin, Alessandro Angelini.
Medchemcomm, 2019 Dec 06; 10(9). PMID: 31803399    Free PMC article.
Review.
The Role of Immune Checkpoint Blockade in Uveal Melanoma.
Anja Wessely, Theresa Steeb, +5 authors, Markus Vincent Heppt.
Int J Mol Sci, 2020 Feb 06; 21(3). PMID: 32013269    Free PMC article.
Review.
Genetic and Environmental Interaction in Type 1 Diabetes: a Relationship Between Genetic Risk Alleles and Molecular Traits of Enterovirus Infection?
Marfa Blanter, Helena Sork, Soile Tuomela, Malin Flodström-Tullberg.
Curr Diab Rep, 2019 Aug 12; 19(9). PMID: 31401790    Free PMC article.
Review.
Current Advances in the Treatment of BRAF-Mutant Melanoma.
Hima Patel, Nour Yacoub, +4 authors, Joan T Garrett.
Cancers (Basel), 2020 Feb 26; 12(2). PMID: 32092958    Free PMC article.
Review.
Prospects for combining immune checkpoint blockade with PARP inhibition.
Anping Li, Ming Yi, +3 authors, Kongming Wu.
J Hematol Oncol, 2019 Sep 16; 12(1). PMID: 31521196    Free PMC article.
Review.
Checkpoint inhibitor blockade and epigenetic reprogrammability in CD8+ T-cell activation and exhaustion.
José Belizário, Maria Fernanda Destro Rodrigues.
Ther Adv Vaccines Immunother, 2020 Mar 25; 8. PMID: 32206744    Free PMC article.
Review.
In silico analysis of the immune microenvironment in bladder cancer.
Ye Zhang, De-Hua Ou, +2 authors, Ming-En Lin.
BMC Cancer, 2020 Apr 02; 20(1). PMID: 32228629    Free PMC article.
Single-Cell Approaches to Profile the Response to Immune Checkpoint Inhibitors.
Lara Gibellini, Sara De Biasi, +5 authors, Andrea Cossarizza.
Front Immunol, 2020 Apr 09; 11. PMID: 32265933    Free PMC article.
Review.
Identification of susceptibility SNPs in CTLA-4 and PTPN22 for scleritis in Han Chinese.
F Li, X Ma, +7 authors, P Yang.
Clin Exp Immunol, 2019 Mar 29; 197(2). PMID: 30921471    Free PMC article.
Effect of Cytotoxic T-Lymphocyte Antigen-4 on the Efficacy of the Fatty Acid-Binding Protein Vaccine Against Schistosoma japonicum.
Chun-Lian Tang, Qun Pan, +3 authors, Jin Huang.
Front Immunol, 2019 May 28; 10. PMID: 31134084    Free PMC article.
BTLA-Expressing Dendritic Cells in Patients With Tuberculosis Exhibit Reduced Production of IL-12/IFN-α and Increased Production of IL-4 and TGF-β, Favoring Th2 and Foxp3+ Treg Polarization.
Jun-Ai Zhang, Yuan-Bin Lu, +13 authors, Jun-Fa Xu.
Front Immunol, 2020 Apr 17; 11. PMID: 32296431    Free PMC article.
Chronic Implant-Related Bone Infections-Can Immune Modulation be a Therapeutic Strategy?
Elisabeth Seebach, Katharina F Kubatzky.
Front Immunol, 2019 Aug 10; 10. PMID: 31396229    Free PMC article.
Review.
T cell costimulation, checkpoint inhibitors and anti-tumor therapy.
Dipankar Nandi, Sanmoy Pathak, +6 authors, Vijayamahantesh.
J Biosci, 2020 Apr 30; 45. PMID: 32345776
Review.
The microenvironmental niche in classic Hodgkin lymphoma is enriched for CTLA-4-positive T cells that are PD-1-negative.
Sanjay S Patel, Jason L Weirather, +6 authors, Scott J Rodig.
Blood, 2019 Nov 08; 134(23). PMID: 31697809    Free PMC article.
Hypoxia-Driven Immune Escape in the Tumor Microenvironment.
Alyssa Vito, Nader El-Sayes, Karen Mossman.
Cells, 2020 Apr 23; 9(4). PMID: 32316260    Free PMC article.
Review.
Exploration of the personalized immune checkpoint atlas of plasma cell dyscrasias patients using high‑dimensional single‑cell analysis.
Chenggong Tu, Yongjiang Zheng, Hui Zhang, Jinheng Wang.
Oncol Rep, 2020 Apr 23; 44(1). PMID: 32319658    Free PMC article.
CTLA4 +49AG (rs231775) and CT60 (rs3087243) gene variants are not associated with alopecia areata in a Mexican population from Monterrey Mexico.
Mauricio Andrés Salinas-Santander, Cristina Susana Cantu-Salinas, +3 authors, Celia Nohemi Sanchez-Dominguez.
An Bras Dermatol, 2020 Apr 13; 95(3). PMID: 32278632    Free PMC article.
New Treatments in Renal Cancer: The AhR Ligands.
Boris Itkin, Alastair Breen, +3 authors, Andrea Irene Loaiza-Perez.
Int J Mol Sci, 2020 May 24; 21(10). PMID: 32443455    Free PMC article.
Review.
Immune Checkpoint Inhibitors for Lung Cancer Treatment: A Review.
Keisuke Onoi, Yusuke Chihara, +6 authors, Koichi Takayama.
J Clin Med, 2020 May 10; 9(5). PMID: 32384677    Free PMC article.
Review.
NF-κB and Its Role in Checkpoint Control.
Annika C Betzler, Marie-Nicole Theodoraki, +4 authors, Cornelia Brunner.
Int J Mol Sci, 2020 Jun 04; 21(11). PMID: 32486375    Free PMC article.
Review.
The efficacy and safety of combined immune checkpoint inhibitors (nivolumab plus ipilimumab): a systematic review and meta-analysis.
Jingjie Chen, Shengnan Li, +8 authors, Yingying Tang.
World J Surg Oncol, 2020 Jul 06; 18(1). PMID: 32620130    Free PMC article.
Systematic Review.
Inflammatory Cytokines Induce Sustained CTLA-4 Cell Surface Expression on Human MAIT Cells.
Julia D Berkson, Chloe K Slichter, +10 authors, Martin Prlic.
Immunohorizons, 2020 Jan 25; 4(1). PMID: 31974109    Free PMC article.
Advances in targeted therapy for malignant lymphoma.
Li Wang, Wei Qin, +5 authors, Wei-Li Zhao.
Signal Transduct Target Ther, 2020 Apr 17; 5(1). PMID: 32296035    Free PMC article.
Review.
IFN-γ: A cytokine at the right time, is in the right place.
J Daniel Burke, Howard A Young.
Semin Immunol, 2019 Jun 22; 43. PMID: 31221552    Free PMC article.
Review.
The relationship of the immune response mediator genes’ polymorphic variants with the methotrexate efficacy in juvenile idiopathic arthritis
Liliia Nazarova, Ksenia Danilko, +3 authors, Tatiana Viktorova.
Turk J Med Sci, 2020 Jan 21; 50(4). PMID: 31958219    Free PMC article.
Autophagy-lysosome inhibitor chloroquine prevents CTLA-4 degradation of T cells and attenuates acute rejection in murine skin and heart transplantation.
Jikai Cui, Jizhang Yu, +8 authors, Jie Wu.
Theranostics, 2020 Jul 30; 10(18). PMID: 32724457    Free PMC article.
Immunophenotypes Based on the Tumor Immune Microenvironment Allow for Unsupervised Penile Cancer Patient Stratification.
Chengbiao Chu, Kai Yao, +5 authors, Yun Cao.
Cancers (Basel), 2020 Jul 09; 12(7). PMID: 32635549    Free PMC article.
Harnessing NK Cell Checkpoint-Modulating Immunotherapies.
Sachin Kumar Singh Chauhan, Ulrike Koehl, Stephan Kloess.
Cancers (Basel), 2020 Jul 10; 12(7). PMID: 32640575    Free PMC article.
Review.
Epigenetic Mechanisms of Resistance to Immune Checkpoint Inhibitors.
Alexandre Perrier, Audrey Didelot, +2 authors, Simon Garinet.
Biomolecules, 2020 Jul 28; 10(7). PMID: 32708698    Free PMC article.
Review.
Intravital Imaging of Adoptive T-Cell Morphology, Mobility and Trafficking Following Immune Checkpoint Inhibition in a Mouse Melanoma Model.
Doreen Lau, Fabien Garçon, +6 authors, Ferdia A Gallagher.
Front Immunol, 2020 Aug 15; 11. PMID: 32793206    Free PMC article.
Prognostic value of FoxP3 and CTLA-4 expression in patients with oral squamous cell carcinoma.
Kazushige Koike, Hironari Dehari, +10 authors, Akihiro Miyazaki.
PLoS One, 2020 Aug 14; 15(8). PMID: 32785290    Free PMC article.
Cancer Nanomedicine Special Issue Review Anticancer Drug Delivery with Nanoparticles: Extracellular Vesicles or Synthetic Nanobeads as Therapeutic Tools for Conventional Treatment or Immunotherapy.
Maria Raffaella Zocchi, Francesca Tosetti, Roberto Benelli, Alessandro Poggi.
Cancers (Basel), 2020 Jul 17; 12(7). PMID: 32668783    Free PMC article.
Review.
Harnessing the Complete Repertoire of Conventional Dendritic Cell Functions for Cancer Immunotherapy.
Lukas Amon, Lukas Hatscher, +2 authors, Christian H K Lehmann.
Pharmaceutics, 2020 Jul 18; 12(7). PMID: 32674488    Free PMC article.
Review.
Advances in Therapeutic Targeting of Cancer Stem Cells within the Tumor Microenvironment: An Updated Review.
Kevin Dzobo, Dimakatso Alice Senthebane, +3 authors, Collet Dandara.
Cells, 2020 Aug 23; 9(8). PMID: 32823711    Free PMC article.
Review.
Pharmacological Activation of Estrogen Receptor Beta Overcomes Tumor Resistance to Immune Checkpoint Blockade Therapy.
Shuang Huang, Nianxin Zhou, +14 authors, Shengtao Zhou.
iScience, 2020 Aug 31; 23(9). PMID: 32861994    Free PMC article.
Biomarkers of immunotherapy in non-small cell lung cancer.
Lingling Wang, Yue Hu, +2 authors, Xiaochen Wang.
Oncol Lett, 2020 Sep 17; 20(5). PMID: 32934707    Free PMC article.
Review.
The mechanism and risk factors for immune checkpoint inhibitor pneumonitis in non-small cell lung cancer patients.
Xiaoyang Zhai, Jian Zhang, +4 authors, Hui Zhu.
Cancer Biol Med, 2020 Sep 19; 17(3). PMID: 32944393    Free PMC article.
Review.
Circulating microRNAs and their role in the immune response in triple-negative breast cancer.
Patricia Piña-Sánchez, Hilda-Alicia Valdez-Salazar, Martha-Eugenia Ruiz-Tachiquín.
Oncol Lett, 2020 Sep 25; 20(5). PMID: 32968446    Free PMC article.
Review.
Immunotherapy Associated Pulmonary Toxicity: Biology Behind Clinical and Radiological Features.
Michele Porcu, Pushpamali De Silva, +8 authors, Luca Saba.
Cancers (Basel), 2019 Mar 08; 11(3). PMID: 30841554    Free PMC article.
Review.
Resisting Resistance to Immune Checkpoint Therapy: A Systematic Review.
Yolla Haibe, Ziad El Husseini, Rola El Sayed, Ali Shamseddine.
Int J Mol Sci, 2020 Sep 02; 21(17). PMID: 32867025    Free PMC article.
Systematic Review.
ICOS+ Tregs: A Functional Subset of Tregs in Immune Diseases.
Dan-Yang Li, Xian-Zhi Xiong.
Front Immunol, 2020 Sep 29; 11. PMID: 32983168    Free PMC article.
Review.
Immune reconstitution and clinical recovery following anti-CD28 antibody (TGN1412)-induced cytokine storm.
Nicki Panoskaltsis, Neil E McCarthy, +9 authors, Stella C Knight.
Cancer Immunol Immunother, 2020 Oct 10; 70(4). PMID: 33033851    Free PMC article.
Natural killer cells in the human lung tumor microenvironment display immune inhibitory functions.
Jules Russick, Pierre-Emmanuel Joubert, +18 authors, Isabelle Cremer.
J Immunother Cancer, 2020 Oct 18; 8(2). PMID: 33067317    Free PMC article.
Predictive Biomarkers of Immune Checkpoint Inhibitors-Related Toxicities.
Ya Xu, Yang Fu, +2 authors, Bicheng Zhang.
Front Immunol, 2020 Oct 31; 11. PMID: 33123120    Free PMC article.
Review.
High expression levels of DEF6 predicts a poor prognosis for patients with clear cell renal cell carcinoma.
Zhen-Peng Zhu, Lan-Ruo Lin, +3 authors, Jian Lin.
Oncol Rep, 2020 Oct 02; 44(5). PMID: 33000227    Free PMC article.
Radiotherapy-Mediated Immunomodulation and Anti-Tumor Abscopal Effect Combining Immune Checkpoint Blockade.
Xinrui Zhao, Chunlin Shao.
Cancers (Basel), 2020 Oct 01; 12(10). PMID: 32992835    Free PMC article.
Review.
CTLA-4 and HLA-DQ are key molecules in the regulation of mDC-mediated cellular immunity by Tregs in severe aplastic anemia.
Bingnan Liu, Yuanyuan Shao, +4 authors, Rong Fu.
J Clin Lab Anal, 2020 Jul 06; 34(10). PMID: 32621335    Free PMC article.
Exosomal PD-L1 functions as an immunosuppressant to promote wound healing.
Dandan Su, Hsiang-I Tsai, +12 authors, Fang Cheng.
J Extracell Vesicles, 2020 Nov 03; 9(1). PMID: 33133428    Free PMC article.
A prognostic risk model based on immune-related genes predicts overall survival of patients with hepatocellular carcinoma.
Banglun Pan, Lin Liu, Wei Li.
Health Sci Rep, 2020 Nov 19; 3(4). PMID: 33204848    Free PMC article.
Chromosome 2q33genetic polymorphisms in Tunisian endemic pemphigus foliaceus.
Olfa Abida, Emna Bahloul, +6 authors, Hatem Masmoudi.
Mol Genet Genomic Med, 2020 Sep 03; 8(11). PMID: 32875738    Free PMC article.
Emerging Role of Immunotherapy for Colorectal Cancer with Liver Metastasis.
Xianzhe Yu, Lingling Zhu, +3 authors, Jianguo Li.
Onco Targets Ther, 2020 Nov 24; 13. PMID: 33223838    Free PMC article.
Review.
B Cells versus T Cells in the Tumor Microenvironment of Malignant Lymphomas. Are the Lymphocytes Playing the Roles of Muhammad Ali versus George Foreman in Zaire 1974?
Minodora Desmirean, Sebastian Rauch, +16 authors, Ciprian Tomuleasa.
J Clin Med, 2020 Oct 30; 9(11). PMID: 33114418    Free PMC article.
Review.
Liposome-Based Drug Delivery Systems in Cancer Immunotherapy.
Zili Gu, Candido G Da Silva, +2 authors, Luis J Cruz.
Pharmaceutics, 2020 Nov 08; 12(11). PMID: 33158166    Free PMC article.
Review.
Immune Checkpoint Blockade in Gynecologic Cancers: State of Affairs.
Maureen L Drakes, Cheryl M Czerlanis, Patrick J Stiff.
Cancers (Basel), 2020 Nov 14; 12(11). PMID: 33182298    Free PMC article.
Review.
Will Next-Generation Immunotherapy Overcome the Intrinsic Diversity and Low Immunogenicity of Sarcomas to Improve Clinical Benefit?
Hui Yi Chew, Victor Chan, Fiona Simpson, Riccardo Dolcetti.
Cancers (Basel), 2020 Nov 20; 12(11). PMID: 33207697    Free PMC article.
Review.
Antigen-loaded dendritic cells triggers a specific cytotoxic T lymphocytes immune response against hepatocellular carcinoma: in vitro study.
N E El-Ashmawy, E A El-Zamarany, +2 authors, O A El-Feky.
Clin Transl Oncol, 2018 Oct 29; 21(5). PMID: 30368725
Cancer research in the era of immunogenomics.
Yochai Wolf, Yardena Samuels.
ESMO Open, 2019 Jan 10; 3(7). PMID: 30622743    Free PMC article.
Review.
Anti-CTLA-4 monoclonal antibody improves efficacy of the glyceraldehyde-3-phosphate dehydrogenase protein vaccine against Schistosoma japonicum in mice.
Chun-Lian Tang, Jin-Feng Yang, +4 authors, Hong-Hua Zhou.
Parasitol Res, 2019 Jun 07; 118(7). PMID: 31168702
MRPL13 is a Prognostic Cancer Biomarker and Correlates with Immune Infiltrates in Breast Cancer.
Zuo Tao, Huandan Suo, +7 authors, Bo Chen.
Onco Targets Ther, 2020 Dec 05; 13. PMID: 33273831    Free PMC article.
How to evaluate for immunodeficiency in patients with autoimmune cytopenias: laboratory evaluation for the diagnosis of inborn errors of immunity associated with immune dysregulation.
Roshini S Abraham.
Hematology Am Soc Hematol Educ Program, 2020 Dec 05; 2020(1). PMID: 33275711    Free PMC article.
Review.
Current Trends in Cancer Immunotherapy.
Ivan Y Filin, Valeriya V Solovyeva, +2 authors, Albert A Rizvanov.
Biomedicines, 2020 Dec 23; 8(12). PMID: 33348704    Free PMC article.
Review.
Heterogeneous Tumor-Immune Microenvironments between Primary and Metastatic Tumors in a Patient with ALK Rearrangement-Positive Large Cell Neuroendocrine Carcinoma.
Takahiro Tashiro, Kosuke Imamura, +10 authors, Takuro Sakagami.
Int J Mol Sci, 2020 Dec 24; 21(24). PMID: 33352665    Free PMC article.
CD47 expression in gastric cancer clinical correlates and association with macrophage infiltration.
Mingsu Shi, Yun Gu, +14 authors, Weijuan Zhang.
Cancer Immunol Immunother, 2021 Jan 04; 70(7). PMID: 33389016
Near-infrared photoimmunotherapy of cancer: a new approach that kills cancer cells and enhances anti-cancer host immunity.
Hisataka Kobayashi, Aki Furusawa, Adrian Rosenberg, Peter L Choyke.
Int Immunol, 2020 Jun 05; 33(1). PMID: 32496557    Free PMC article.
Genomic profiling of T-cell activation suggests increased sensitivity of memory T cells to CD28 costimulation.
Dafni A Glinos, Blagoje Soskic, +4 authors, Gosia Trynka.
Genes Immun, 2020 Nov 24; 21(6-8). PMID: 33223527    Free PMC article.
Predicting Responses to Checkpoint Inhibitors in Lymphoma: Are We Up to the Standards of Solid Tumors?
Ah-Reum Jeong, Edward D Ball, Aaron Michael Goodman.
Clin Med Insights Oncol, 2021 Jan 16; 14. PMID: 33447123    Free PMC article.
Review.
Fine-Tuning the Tumour Microenvironment: Current Perspectives on the Mechanisms of Tumour Immunosuppression.
Jesse D Armitage, Hannah V Newnes, +2 authors, Jason Waithman.
Cells, 2021 Jan 07; 10(1). PMID: 33401460    Free PMC article.
Review.
Recent Advances in Monoclonal Antibody Therapy for Colorectal Cancers.
Kyusang Hwang, Jin Hwan Yoon, Ji Hyun Lee, Sukmook Lee.
Biomedicines, 2021 Jan 21; 9(1). PMID: 33466394    Free PMC article.
Review.
Immune-Checkpoint Inhibitors in B-Cell Lymphoma.
Marc Armengol, Juliana Carvalho Santos, +3 authors, Gaël Roué.
Cancers (Basel), 2021 Jan 13; 13(2). PMID: 33430146    Free PMC article.
Review.
SARS-CoV-2 infection: The role of PD-1/PD-L1 and CTLA-4 axis.
Parisa Shiri Aghbash, Narges Eslami, +2 authors, Hossein Bannazadeh Baghi.
Life Sci, 2021 Jan 29; 270. PMID: 33508291    Free PMC article.
Review.
A Comprehensive Prognostic and Immune Analysis of SLC41A3 in Pan-Cancer.
Jun Liu, Shanqiang Zhang, +2 authors, Ji-Cheng Li.
Front Oncol, 2021 Feb 02; 10. PMID: 33520701    Free PMC article.
Oral administration of Bifidobacterium breve promotes antitumor efficacy via dendritic cells-derived interleukin 12.
Qingxiang Li, Yuke Li, +5 authors, Chuanbin Guo.
Oncoimmunology, 2021 Feb 05; 10(1). PMID: 33537172    Free PMC article.
Single-cell RNA-sequencing analyses identify heterogeneity of CD8+ T cell subpopulations and novel therapy targets in melanoma.
Weiwei Deng, Yubo Ma, +9 authors, Ruoyu Li.
Mol Ther Oncolytics, 2021 Feb 13; 20. PMID: 33575475    Free PMC article.
Development of an Oncogenic Driver Alteration Associated Immune-Related Prognostic Model for Stage I-II Lung Adenocarcinoma.
Jian-Zhao Xu, Chen Gong, Zheng-Fu Xie, Hua Zhao.
Front Oncol, 2021 Feb 16; 10. PMID: 33585210    Free PMC article.
A T cell repertoire timestamp is at the core of responsiveness to CTLA-4 blockade.
Hagit Philip, Tom Snir, +3 authors, Sol Efroni.
iScience, 2021 Feb 20; 24(2). PMID: 33604527    Free PMC article.
Dietary betaine prevents obesity through gut microbiota-drived microRNA-378a family.
Jingjing Du, Peiwen Zhang, +25 authors, Li Zhu.
Gut Microbes, 2021 Feb 09; 13(1). PMID: 33550882    Free PMC article.
Recent Advancements in the Mechanisms Underlying Resistance to PD-1/PD-L1 Blockade Immunotherapy.
Yu Yuan, Abdalla Adam, Chen Zhao, Honglei Chen.
Cancers (Basel), 2021 Feb 11; 13(4). PMID: 33562324    Free PMC article.
Review.
Identification of a 14-Gene Prognostic Signature for Diffuse Large B Cell Lymphoma (DLBCL).
Pengcheng Feng, Hongxia Li, +2 authors, Guixia Li.
Front Genet, 2021 Mar 02; 12. PMID: 33643388    Free PMC article.
High expression of CDCA7 predicts poor prognosis for clear cell renal cell carcinoma and explores its associations with immunity.
Shouyong Liu, Yi Wang, +2 authors, Zengjun Wang.
Cancer Cell Int, 2021 Mar 03; 21(1). PMID: 33648519    Free PMC article.
The Roles of Immunoregulatory Networks in Severe Drug Hypersensitivity.
Yun-Shiuan Olivia Hsu, Kun-Lin Lu, +8 authors, Chun-Bing Chen.
Front Immunol, 2021 Mar 16; 12. PMID: 33717075    Free PMC article.
Review.
Association of Survival and Immune-Related Adverse Events With Anti-PD-1/PD-L1 and Anti-CTLA-4 Inhibitors, Alone or Their Combination for the Treatment of Cancer: A Systematic Review and Meta-Analysis of 13 Clinical Trials.
Leyin Zhang, Leitao Sun, +5 authors, Shanming Ruan.
Front Oncol, 2021 Mar 16; 11. PMID: 33718135    Free PMC article.
Systematic Review.
A Review of Monoclonal Antibody-Based Treatments in Non-small Cell Lung Cancer.
Yunes Panahi, Amir Hossein Mohammadzadeh, +3 authors, Amirhossein Sahebkar.
Adv Exp Med Biol, 2021 Mar 17; 1286. PMID: 33725344
Review.
Lipid Metabolism and Immune Checkpoints.
Qianjin Liao, Yujuan Zhou, Longzheng Xia, Deliang Cao.
Adv Exp Med Biol, 2021 Mar 20; 1316. PMID: 33740251
Immune Modeling Analysis Reveals Immunologic Signatures Associated With Improved Outcomes in High Grade Serous Ovarian Cancer.
Nicole E James, Katherine Miller, +4 authors, Jennifer R Ribeiro.
Front Oncol, 2021 Mar 23; 11. PMID: 33747935    Free PMC article.
Identification of a Prognostic Signature Model with Tumor Microenvironment for predicting Disease-free Survival after Radical Prostatectomy.
Hao Zhao, Xuening Zhang, +5 authors, Songhe Shi.
J Cancer, 2021 Mar 25; 12(8). PMID: 33758613    Free PMC article.
Insulin-mediated immune dysfunction in the development of preeclampsia.
Gustav van Niekerk, Claudia Christowitz, Anna-Mart Engelbrecht.
J Mol Med (Berl), 2021 Mar 27; 99(7). PMID: 33768298
Review.
Activating Mutation of SHP2 Establishes a Tumorigenic Phonotype Through Cell-Autonomous and Non-Cell-Autonomous Mechanisms.
Lei Dong, Da Han, +3 authors, Qin Xia.
Front Cell Dev Biol, 2021 Mar 30; 9. PMID: 33777940    Free PMC article.
Review.
Immunosuppressive Cell Subsets and Factors in Myeloid Leukemias.
Julian Swatler, Laura Turos-Korgul, Ewa Kozlowska, Katarzyna Piwocka.
Cancers (Basel), 2021 Apr 04; 13(6). PMID: 33801964    Free PMC article.
Review.
Targeting Genome Stability in Melanoma-A New Approach to an Old Field.
Marta Osrodek, Michal Wozniak.
Int J Mol Sci, 2021 Apr 04; 22(7). PMID: 33800547    Free PMC article.
Review.
Mechanisms of Immune Evasion in Acute Lymphoblastic Leukemia.
Agata Pastorczak, Krzysztof Domka, +2 authors, Malgorzata Firczuk.
Cancers (Basel), 2021 Apr 04; 13(7). PMID: 33810515    Free PMC article.
Review.
Exploration of modified progression-free survival as a novel surrogate endpoint for overall survival in immuno-oncology trials.
Zi-Xian Wang, Hao-Xiang Wu, +5 authors, Rui-Hua Xu.
J Immunother Cancer, 2021 Apr 03; 9(4). PMID: 33795385    Free PMC article.
Is There a Place for PD-1-PD-L Blockade in Acute Myeloid Leukemia?
Laura Jimbu, Oana Mesaros, +5 authors, Mihnea Zdrenghea.
Pharmaceuticals (Basel), 2021 Apr 04; 14(4). PMID: 33804850    Free PMC article.
Review.
The Future of Cancer Diagnosis, Treatment and Surveillance: A Systemic Review on Immunotherapy and Immuno-PET Radiotracers.
Virginia Liberini, Riccardo Laudicella, +5 authors, Désirée Deandreis.
Molecules, 2021 May 01; 26(8). PMID: 33920423    Free PMC article.
Systematic Review.
Immune Checkpoints, Inhibitors and Radionuclides in Prostate Cancer: Promising Combinatorial Therapy Approach.
Mankgopo M Kgatle, Tebatso M G Boshomane, +7 authors, Mike M Sathekge.
Int J Mol Sci, 2021 May 01; 22(8). PMID: 33921181    Free PMC article.
Review.
Reprogramming Immune Cells for Enhanced Cancer Immunotherapy: Targets and Strategies.
Yan Dong, Zhuo Wan, +2 authors, Li Liu.
Front Immunol, 2021 May 11; 12. PMID: 33968014    Free PMC article.
Review.
Local Depletion of Immune Checkpoint Ligand CTLA4 Expressing Cells in Tumor Beds Enhances Antitumor Host Immunity.
Ryuhei Okada, Takuya Kato, +4 authors, Hisataka Kobayashi.
Adv Ther (Weinh), 2021 May 18; 4(5). PMID: 33997271    Free PMC article.
The regulation of immune checkpoints by the hypoxic tumor microenvironment.
Min Hu, Yongfu Li, +5 authors, Hong Zhao.
PeerJ, 2021 May 21; 9. PMID: 34012727    Free PMC article.
Enhancing a Natural Killer: Modification of NK Cells for Cancer Immunotherapy.
Rasa Islam, Aleta Pupovac, +4 authors, Alan Trounson.
Cells, 2021 May 06; 10(5). PMID: 33946954    Free PMC article.
Review.
Immunomodulatory Effects of BRAF, MEK, and CDK4/6 Inhibitors: Implications for Combining Targeted Therapy and Immune Checkpoint Blockade for the Treatment of Melanoma.
Emily J Lelliott, Grant A McArthur, Jane Oliaro, Karen E Sheppard.
Front Immunol, 2021 May 25; 12. PMID: 34025662    Free PMC article.
Review.
CD24 Contributes to Treatment Effect in ABC-DLBCL Patients with R-CHOP Resistance.
Li-Yan Qiao, Han-Bing Li, +3 authors, Yi-Qun Che.
Pharmgenomics Pers Med, 2021 Jun 04; 14. PMID: 34079334    Free PMC article.
Regulatory mechanisms of immune checkpoints PD-L1 and CTLA-4 in cancer.
Hao Zhang, Ziyu Dai, +6 authors, Quan Cheng.
J Exp Clin Cancer Res, 2021 Jun 06; 40(1). PMID: 34088360    Free PMC article.
Review.
CRISPR/Cas9 Gene-Editing in Cancer Immunotherapy: Promoting the Present Revolution in Cancer Therapy and Exploring More.
Xuejin Ou, Qizhi Ma, +2 authors, Zhiyao He.
Front Cell Dev Biol, 2021 Jun 08; 9. PMID: 34095145    Free PMC article.
Review.
Harnessing the epigenome to boost immunotherapy response in non-small cell lung cancer patients.
Anastasios Gkountakos, Pietro Delfino, +3 authors, Emilio Bria.
Ther Adv Med Oncol, 2021 Jun 10; 13. PMID: 34104224    Free PMC article.
Review.
Near Infrared Photoimmunotherapy; A Review of Targets for Cancer Therapy.
Takuya Kato, Hiroaki Wakiyama, +2 authors, Hisataka Kobayashi.
Cancers (Basel), 2021 Jun 03; 13(11). PMID: 34064074    Free PMC article.
Review.
Mechanism-based treatment of cancer with immune checkpoint inhibitor therapies.
Yara Abdou, Manu Pandey, +3 authors, Marc S Ernstoff.
Br J Clin Pharmacol, 2020 Apr 24; 86(9). PMID: 32323342    Free PMC article.
Review.
Immunotherapy in AML: a brief review on emerging strategies.
A Moeinafshar, S Hemmati, N Rezaei.
Clin Transl Oncol, 2021 Jun 24; 23(12). PMID: 34160771
Review.
Functional categories of immune inhibitory receptors.
Matevž Rumpret, Julia Drylewicz, +3 authors, Linde Meyaard.
Nat Rev Immunol, 2020 Jul 03; 20(12). PMID: 32612208
Review.
PET Imaging of CD8 via SMART for Monitoring the Immunotherapy Response.
Lingyi Sun, Zhonghan Li, +3 authors, Dexing Zeng.
Biomed Res Int, 2021 Jul 03; 2021. PMID: 34212037    Free PMC article.
Inhibitors of immune checkpoints-PD-1, PD-L1, CTLA-4-new opportunities for cancer patients and a new challenge for internists and general practitioners.
Marek Z Wojtukiewicz, Magdalena M Rek, +7 authors, Kenneth V Honn.
Cancer Metastasis Rev, 2021 Jul 09; 40(3). PMID: 34236546    Free PMC article.
Review.
Autoimmunity as an Etiological Factor of Cancer: The Transformative Potential of Chronic Type 2 Inflammation.
Chris M Li, Zhibin Chen.
Front Cell Dev Biol, 2021 Jul 09; 9. PMID: 34235145    Free PMC article.
Review.
TGF-β1 Induces Immune Escape by Enhancing PD-1 and CTLA-4 Expression on T Lymphocytes in Hepatocellular Carcinoma.
Shixiang Bao, Xiaopei Jiang, +2 authors, Jingtao Lu.
Front Oncol, 2021 Jul 13; 11. PMID: 34249750    Free PMC article.
CARS as a Prognosis Factor in Clear Cell Renal Cell Carcinoma and Its Association with Tumor Immunity.
Quan Meng, Can-Xuan Li, Dan Long.
Int J Gen Med, 2021 Jul 16; 14. PMID: 34262333    Free PMC article.
Regulatory Mechanisms of LncRNAs in Cancer Glycolysis: Facts and Perspectives.
Peng Huang, Shaomi Zhu, +4 authors, Linjiang Song.
Cancer Manag Res, 2021 Jul 16; 13. PMID: 34262341    Free PMC article.
Review.
Detection of Immune Checkpoint Receptors - A Current Challenge in Clinical Flow Cytometry.
Benjamin Shibru, Katharina Fey, +8 authors, Andreas Boldt.
Front Immunol, 2021 Jul 20; 12. PMID: 34276685    Free PMC article.
Review.
Chemoresistance and Metastasis in Breast Cancer Molecular Mechanisms and Novel Clinical Strategies.
Jun Cao, Mengdi Zhang, +3 authors, Fangfang Zhou.
Front Oncol, 2021 Jul 20; 11. PMID: 34277408    Free PMC article.
Review.
IQGAP3 May Serve as a Promising Biomarker in Clear Cell Renal Cell Carcinoma.
Quan Meng, Can-Xuan Li, Dan Long, Xiaobin Lin.
Int J Gen Med, 2021 Jul 22; 14. PMID: 34285569    Free PMC article.
Genetic association studies of alterations in protein function expose recessive effects on cancer predisposition.
Nadav Brandes, Nathan Linial, Michal Linial.
Sci Rep, 2021 Jul 23; 11(1). PMID: 34290314    Free PMC article.
Ultrasound-mediated microbubbles cavitation enhanced chemotherapy of advanced prostate cancer by increasing the permeability of blood-prostate barrier.
Haizhui Xia, Decao Yang, +11 authors, Jian Lu.
Transl Oncol, 2021 Jul 17; 14(10). PMID: 34271256    Free PMC article.
Ovarian Cancer: Therapeutic Strategies to Overcome Immune Suppression.
Maureen L Drakes, Patrick J Stiff.
Adv Exp Med Biol, 2021 Aug 03; 1330. PMID: 34339029
Potential protective role of the anti-PD-1 blockade against SARS-CoV-2 infection.
Annoor Awadasseid, Qiang Yin, Yanling Wu, Wen Zhang.
Biomed Pharmacother, 2021 Aug 03; 142. PMID: 34339917    Free PMC article.
Review.
PD-L1/PD-1 and CTLA-4 Expression in Equine Penile Squamous Cell Carcinomas.
Ilaria Porcellato, Samanta Mecocci, +11 authors, Elisabetta Razzuoli.
Animals (Basel), 2021 Aug 08; 11(7). PMID: 34359249    Free PMC article.
Combining Cancer Vaccines with Immunotherapy: Establishing a New Immunological Approach.
Chang-Gon Kim, Yun-Beom Sang, Ji-Hyun Lee, Hong-Jae Chon.
Int J Mol Sci, 2021 Aug 08; 22(15). PMID: 34360800    Free PMC article.
Review.
Transfer learning between preclinical models and human tumors identifies a conserved NK cell activation signature in anti-CTLA-4 responsive tumors.
Emily F Davis-Marcisak, Allison A Fitzgerald, +5 authors, Elana J Fertig.
Genome Med, 2021 Aug 12; 13(1). PMID: 34376232    Free PMC article.
DTYMK Expression Predicts Prognosis and Chemotherapeutic Response and Correlates with Immune Infiltration in Hepatocellular Carcinoma.
Yiwen Guo, Weixin Luo, +10 authors, Maogen Chen.
J Hepatocell Carcinoma, 2021 Aug 12; 8. PMID: 34377684    Free PMC article.
Targeting the tumor microenvironment in B-cell lymphoma: challenges and opportunities.
Yingyue Liu, Xiangxiang Zhou, Xin Wang.
J Hematol Oncol, 2021 Aug 19; 14(1). PMID: 34404434    Free PMC article.
Review.
Immune PET Imaging.
Osigbemhe Iyalomhe, Michael D Farwell.
Radiol Clin North Am, 2021 Aug 17; 59(5). PMID: 34392924    Free PMC article.
Review.
Effects of infections on the pathogenesis of cancer.
Rocco Luca Emanuele Liardo, Antonio Maria Borzì, +5 authors, Marco Vacante.
Indian J Med Res, 2021 Aug 13; 153(4). PMID: 34380789    Free PMC article.
Review.
Unraveling the thread of uncontrolled immune response in COVID-19 and STEMI: an emerging need for knowledge sharing.
Cesar Rios-Navarro, Elena de Dios, Maria J Forteza, Vicente Bodi.
Am J Physiol Heart Circ Physiol, 2021 Apr 13; 320(6). PMID: 33844596    Free PMC article.
Review.
Identification of a Costimulatory Molecule Gene Signature to Predict Survival and Immunotherapy Response in Head and Neck Squamous Cell Carcinoma.
Ling Aye, Xiaole Song, +6 authors, Dehui Wang.
Front Cell Dev Biol, 2021 Aug 27; 9. PMID: 34434928    Free PMC article.
The Landscape of Immunotherapy in Advanced NSCLC: Driving Beyond PD-1/PD-L1 Inhibitors (CTLA-4, LAG3, IDO, OX40, TIGIT, Vaccines).
Andrea De Giglio, Alessandro Di Federico, +2 authors, Francesco Gelsomino.
Curr Oncol Rep, 2021 Aug 29; 23(11). PMID: 34453261    Free PMC article.
Review.
Possible Immunotherapeutic Strategies Based on Carcinogen-Dependent Subgroup Classification for Oral Cancer.
Jiwei Sun, Qingming Tang, +3 authors, Lili Chen.
Front Mol Biosci, 2021 Sep 10; 8. PMID: 34497832    Free PMC article.
Review.
Inhibitory Receptors and Immune Checkpoints Regulating Natural Killer Cell Responses to Cancer.
Irina Buckle, Camille Guillerey.
Cancers (Basel), 2021 Sep 11; 13(17). PMID: 34503073    Free PMC article.
Review.
Identification and Characterization of Robust Hepatocellular Carcinoma Prognostic Subtypes Based on an Integrative Metabolite-Protein Interaction Network.
Di Chen, Yiran Zhang, +17 authors, Hai-Long Piao.
Adv Sci (Weinh), 2021 Jul 12; 8(17). PMID: 34247449    Free PMC article.
Novel Discoveries in Immune Dysregulation in Inborn Errors of Immunity.
Anwen Ren, Wei Yin, +7 authors, Chaohong Liu.
Front Immunol, 2021 Sep 14; 12. PMID: 34512655    Free PMC article.
Review.
Application of Immunotherapy in Hepatocellular Carcinoma.
Lele Miao, Zhengchao Zhang, Zhijian Ren, Yumin Li.
Front Oncol, 2021 Sep 14; 11. PMID: 34513678    Free PMC article.
Review.
High-frequency and activation of CD4+CD25+ T cells maintain persistent immunotolerance induced by congenital ALV-J infection.
Shuhai He, Gaoying Zheng, +3 authors, Ziqiang Cheng.
Vet Res, 2021 Sep 17; 52(1). PMID: 34526112    Free PMC article.
Fibrinogen-like protein 1 (FGL1): the next immune checkpoint target.
Wenjing Qian, Mingfang Zhao, Ruoyu Wang, Heming Li.
J Hematol Oncol, 2021 Sep 17; 14(1). PMID: 34526102    Free PMC article.
Review.
Lower Survival and Increased Circulating Suppressor Cells in Patients with Relapsed/Refractory Diffuse Large B-Cell Lymphoma with Deficit of Vitamin D Levels Using R-GDP Plus Lenalidomide (R2-GDP): Results from the R2-GDP-GOTEL Trial.
Carlos Jiménez-Cortegana, Pilar M Sánchez-Martínez, +7 authors, Víctor Sánchez-Margalet.
Cancers (Basel), 2021 Sep 29; 13(18). PMID: 34572849    Free PMC article.
Short Review on Advances in Hydrogel-Based Drug Delivery Strategies for Cancer Immunotherapy.
Hee Seung Seo, Chi-Pin James Wang, Wooram Park, Chun Gwon Park.
Tissue Eng Regen Med, 2021 Oct 02; 19(2). PMID: 34596839    Free PMC article.
Review.
The role of immunotherapy in advanced renal cell carcinoma: Review.
Ercília Rita Mondlane, Pedro Abreu-Mendes, +2 authors, Fernando Mendes.
Int Braz J Urol, 2021 Mar 03; 47(6). PMID: 33650838    Free PMC article.
Review.
A Focal Adhesion-Related Gene Signature Predicts Prognosis in Glioma and Correlates With Radiation Response and Immune Microenvironment.
Haonan Li, Guohui Wang, +7 authors, Xiaoying Xue.
Front Oncol, 2021 Oct 12; 11. PMID: 34631528    Free PMC article.
Comprehensive Analysis of Clinical Significance, Immune Infiltration and Biological Role of m6A Regulators in Early-Stage Lung Adenocarcinoma.
Bolun Zhou, Shugeng Gao.
Front Immunol, 2021 Oct 16; 12. PMID: 34650549    Free PMC article.
Cardiac Toxicity Associated with Immune Checkpoint Inhibitors: A Systematic Review.
Walid Shalata, Amjad Abu-Salman, +3 authors, Alexander Yakobson.
Cancers (Basel), 2021 Oct 24; 13(20). PMID: 34680365    Free PMC article.
Review.
Integrated bioinformatics analyses of key genes involved in hepatocellular carcinoma immunosuppression.
Hongyan Huang, Youwen Hu, Li Guo, Zhili Wen.
Oncol Lett, 2021 Oct 26; 22(6). PMID: 34691257    Free PMC article.
Targeting cholesterol biosynthesis promotes anti-tumor immunity by inhibiting long noncoding RNA SNHG29-mediated YAP activation.
Wen Ni, Hui Mo, +11 authors, Jianming Li.
Mol Ther, 2021 May 17; 29(10). PMID: 33992804    Free PMC article.
Effect of PTPN22, FAS/FASL, IL2RA and CTLA4 genetic polymorphisms on the risk of developing alopecia areata: A systematic review of the literature and meta-analysis.
S R Gil-Quiñones, I T Sepúlveda-Pachón, G Sánchez Vanegas, L D Gutierrez-Castañeda.
PLoS One, 2021 Nov 05; 16(11). PMID: 34735462    Free PMC article.
Systematic Review.
The Upregulation of Molecules Related to Tumor Immune Escape in Human Pituitary Adenomas.
Zhiyu Xi, Pamela S Jones, +8 authors, Xun Zhang.
Front Endocrinol (Lausanne), 2021 Nov 09; 12. PMID: 34745002    Free PMC article.
Immune Checkpoint Inhibitors in Hepatocellular Carcinoma: Current Progresses and Challenges.
Hao-Tian Liu, Meng-Jie Jiang, +5 authors, Jian-Hong Zhong.
Front Oncol, 2021 Nov 09; 11. PMID: 34745958    Free PMC article.
Review.
[Research Progress of Circular RNAs in Tumor Immunotherapy].
Chenyu Zhang, Lei Peng, Jingbin Ji, Wenjie Jiao.
Zhongguo Fei Ai Za Zhi, 2021 Oct 11; 24(10). PMID: 34628781    Free PMC article.
Exposure to Tobacco Smoking Induces a subset of Activated Tumor-resident Tregs in Non-Small Cell Lung Cancer.
Yudi Hu, Chaoqun Xu, +6 authors, Qiyuan Li.
Transl Oncol, 2021 Nov 13; 15(1). PMID: 34768099    Free PMC article.
Epidemiologic, Clinical and Immunological Consequences of Co-Infections during Canine Leishmaniosis.
Erin A Beasley, Danielle Pessôa-Pereira, Breanna M Scorza, Christine A Petersen.
Animals (Basel), 2021 Nov 28; 11(11). PMID: 34827938    Free PMC article.
Review.
CSMD1 Mutation Related to Immunity Can Be Used as a Marker to Evaluate the Clinical Therapeutic Effect and Prognosis of Patients with Esophageal Cancer.
Xin Fan, Jianxiong Song, +4 authors, Zhiyuan Zhang.
Int J Gen Med, 2021 Dec 02; 14. PMID: 34849012    Free PMC article.
Inhibitory pattern recognition receptors.
Matevž Rumpret, Helen J von Richthofen, Victor Peperzak, Linde Meyaard.
J Exp Med, 2021 Dec 15; 219(1). PMID: 34905019    Free PMC article.
Review.
Current Progress and Future Perspectives of Immune Checkpoint in Cancer and Infectious Diseases.
Xin Cai, Huajie Zhan, +4 authors, Yuan Zhuang.
Front Genet, 2021 Dec 18; 12. PMID: 34917131    Free PMC article.
Review.
Crossed Pathways for Radiation-Induced and Immunotherapy-Related Lung Injury.
Zengfu Zhang, Jialin Zhou, +4 authors, Dawei Chen.
Front Immunol, 2021 Dec 21; 12. PMID: 34925345    Free PMC article.
Review.
Combination of CTLA-4 blockade with MUC1 mRNA nanovaccine induces enhanced anti-tumor CTL activity by modulating tumor microenvironment of triple negative breast cancer.
Xuan Lin, Hedan Chen, +9 authors, Lina Liu.
Transl Oncol, 2021 Dec 08; 15(1). PMID: 34875483    Free PMC article.
The foundations of immune checkpoint blockade and the ipilimumab approval decennial.
Alan J Korman, Sarah C Garrett-Thomson, Nils Lonberg.
Nat Rev Drug Discov, 2021 Dec 24;. PMID: 34937915
Review.
Potential of E3 Ubiquitin Ligases in Cancer Immunity: Opportunities and Challenges.
Peng Ye, Xiaoxia Chi, +4 authors, Wen-Hao Yang.
Cells, 2021 Dec 25; 10(12). PMID: 34943817    Free PMC article.
Review.
Barriers to Immunotherapy in Ovarian Cancer: Metabolic, Genomic, and Immune Perturbations in the Tumour Microenvironment.
Racheal Louise Johnson, Michele Cummings, +3 authors, Nicolas Michel Orsi.
Cancers (Basel), 2021 Dec 25; 13(24). PMID: 34944851    Free PMC article.
Review.
The Transmembrane Receptor TIRC7 Identifies a Distinct Subset of Immune Cells with Prognostic Implications in Cholangiocarcinoma.
Thomas Albrecht, Benjamin Goeppert, +14 authors, Stephanie Roessler.
Cancers (Basel), 2021 Dec 25; 13(24). PMID: 34944891    Free PMC article.
Insights of RKIP-Derived Suppression of Prostate Cancer.
Ying Dong, Xiaozeng Lin, +4 authors, Damu Tang.
Cancers (Basel), 2021 Dec 25; 13(24). PMID: 34945007    Free PMC article.
Review.
Immune System Disorders, Cancer and Viral Infections: A New Treatment Opportunity for the Immune Checkpoint Inhibitors.
Alejandro Olivares-Hernández, Luis Figuero-Pérez, +4 authors, Emilio Fonseca-Sánchez.
Life (Basel), 2021 Dec 25; 11(12). PMID: 34947931    Free PMC article.
Review.
The Impact of the Microbiome on Resistance to Cancer Treatment with Chemotherapeutic Agents and Immunotherapy.
Aneta Sevcikova, Nikola Izoldova, +4 authors, Michal Mego.
Int J Mol Sci, 2022 Jan 12; 23(1). PMID: 35008915    Free PMC article.
Review.
Retrospective analysis of the preparation and application of immunotherapy in cancer treatment (Review).
Jiachen Lu, Jianing Ding, Zhaoxia Liu, Tingtao Chen.
Int J Oncol, 2022 Jan 05; 60(2). PMID: 34981814    Free PMC article.
Hallmarks of response, resistance, and toxicity to immune checkpoint blockade.
Golnaz Morad, Beth A Helmink, Padmanee Sharma, Jennifer A Wargo.
Cell, 2021 Oct 09; 184(21). PMID: 34624224    Free PMC article.
Review.
The DNA damage repair-related gene PKMYT1 is a potential biomarker in various malignancies.
Changjian Shao, Yuanyong Wang, +9 authors, Xiaolong Yan.
Transl Lung Cancer Res, 2022 Jan 25; 10(12). PMID: 35070764    Free PMC article.
Developing and characterizing a single-domain antibody (nanobody) against human cytotoxic T-lymphocyte-associated protein 4 (hCTLA-4).
Nazli Sotoudeh, Zahra Noormohammadi, +2 authors, Mahdi Behdani.
Iran J Basic Med Sci, 2022 Jan 28; 24(9). PMID: 35083014    Free PMC article.
Comprehensive Analysis of the Immune Microenvironment in Checkpoint Inhibitor Pneumonitis.
Xinqing Lin, Jiaxi Deng, +9 authors, Chengzhi Zhou.
Front Immunol, 2022 Feb 01; 12. PMID: 35095920    Free PMC article.
Application of Noninvasive Imaging to Combined Immune Checkpoint Inhibitors for Breast Cancer: Facts and Future.
Zhongquan Cheng, Yang Du, +2 authors, Jie Tian.
Mol Imaging Biol, 2022 Feb 02; 24(2). PMID: 35102468
Review.
A pan-cancer study of PD-1 and CTLA-4 as therapeutic targets.
Zongqiang Cai, Xiaojie Ang, +4 authors, Feng Zhou.
Transl Cancer Res, 2022 Feb 05; 10(9). PMID: 35116697    Free PMC article.
Glioma targeted therapy: insight into future of molecular approaches.
Keyang Yang, Zhijing Wu, +11 authors, Quan Cheng.
Mol Cancer, 2022 Feb 10; 21(1). PMID: 35135556    Free PMC article.
Review.
Semaphorins as Potential Immune Therapeutic Targets for Cancer.
Jun Jiang, Fang Zhang, +4 authors, Rui Zhang.
Front Oncol, 2022 Feb 15; 12. PMID: 35155237    Free PMC article.
Review.
Current progress of immune checkpoint inhibitors in the treatment of advanced hepatocellular carcinoma.
Xiaoqiang Yin, Tongchui Wu, Yadong Lan, Wulin Yang.
Biosci Rep, 2022 Jan 26; 42(2). PMID: 35075482    Free PMC article.
Review.
New Therapeutic Approaches for Conjunctival Melanoma-What We Know So Far and Where Therapy Is Potentially Heading: Focus on Lymphatic Vessels and Dendritic Cells.
Jennifer Peil, Felix Bock, +4 authors, Simona L Schlereth.
Int J Mol Sci, 2022 Feb 16; 23(3). PMID: 35163401    Free PMC article.
Review.
Therapeutic Effect of Catgut Implantation at Acupoint in a Mouse Model of Hepatocellular Carcinoma by Suppressing Immune Escape.
Shi-Hua Xu, Hao-Xuan Luo, +8 authors, Shi-Jun Zhang.
Evid Based Complement Alternat Med, 2022 Feb 19; 2022. PMID: 35178106    Free PMC article.
Prospect of Prostate Cancer Treatment: Armed CAR-T or Combination Therapy.
Yao Jiang, Weihong Wen, +3 authors, Weijun Qin.
Cancers (Basel), 2022 Feb 26; 14(4). PMID: 35205714    Free PMC article.
Review.
The combination of novel immune checkpoints HHLA2 and ICOSLG: A new system to predict survival and immune features in esophageal squamous cell carcinoma.
Chaoqi Zhang, Feng Wang, +8 authors, Jie He.
Genes Dis, 2020 Aug 21; 9(2). PMID: 35224157    Free PMC article.
Colorectal liver metastasis: molecular mechanism and interventional therapy.
Hui Zhou, Zhongtao Liu, +8 authors, Yu Wen.
Signal Transduct Target Ther, 2022 Mar 06; 7(1). PMID: 35246503    Free PMC article.
Review.
Inhibitory immune checkpoint molecules and exhaustion of T cells in COVID-19.
M Barnova, A Bobcakova, +4 authors, M Jesenak.
Physiol Res, 2021 Dec 17; 70(S2). PMID: 34913354    Free PMC article.
Review.
Mutant IDH Inhibits IFNγ-TET2 Signaling to Promote Immunoevasion and Tumor Maintenance in Cholangiocarcinoma.
Meng-Ju Wu, Lei Shi, +30 authors, Nabeel Bardeesy.
Cancer Discov, 2021 Dec 02; 12(3). PMID: 34848557    Free PMC article.
Correlation between Tumor Microenvironment and Immune Subtypes Based on CD8 T Cells Enhancing Personalized Therapy of Gastric Cancer.
Jianyu Wu, Yajie Xiao, +5 authors, Yuzhong Chen.
J Oncol, 2022 Mar 11; 2022. PMID: 35265130    Free PMC article.
Downregulated exosome-associated gene FGF9 as a novel diagnostic and prognostic target for ovarian cancer and its underlying roles in immune regulation.
Zhijie Xu, Yuan Cai, +7 authors, Jinwu Peng.
Aging (Albany NY), 2022 Feb 23; 14(4). PMID: 35190498    Free PMC article.
Soluble Immune Checkpoints Are Dysregulated in COVID-19 and Heavy Alcohol Users With HIV Infection.
Wei Li, Fahim Syed, +10 authors, Qigui Yu.
Front Immunol, 2022 Mar 15; 13. PMID: 35281051    Free PMC article.
Review.
The Clinical Prediction Value of the Ubiquitination Model Reflecting the Immune Traits in LUAD.
Yinggang Che, Dongbo Jiang, +12 authors, Jian Zhang.
Front Immunol, 2022 Mar 15; 13. PMID: 35281055    Free PMC article.
Advances of DNA Damage Repair-Related Drugs and Combination With Immunotherapy in Tumor Treatment.
Yumin Wang, Meihan Duan, +5 authors, Weihong Jiang.
Front Immunol, 2022 Mar 15; 13. PMID: 35281059    Free PMC article.
Review.
Targeted Immunotherapy for Autoimmune Disease.
Seung Min Jung, Wan-Uk Kim.
Immune Netw, 2022 Mar 17; 22(1). PMID: 35291650    Free PMC article.
Review.
Functional Diversities of Regulatory T Cells in the Context of Cancer Immunotherapy.
Ran Gao, Guo-Ping Shi, Jing Wang.
Front Immunol, 2022 Apr 05; 13. PMID: 35371055    Free PMC article.
Review.
The engineered CD80 variant fusion therapeutic davoceticept combines checkpoint antagonism with conditional CD28 costimulation for anti-tumor immunity.
Mark F Maurer, Katherine E Lewis, +17 authors, Stanford L Peng.
Nat Commun, 2022 Apr 06; 13(1). PMID: 35379805    Free PMC article.
Imaging immunity in patients with cancer using positron emission tomography.
Fiona Hegi-Johnson, Stacey Rudd, +9 authors, Michael P MacManus.
NPJ Precis Oncol, 2022 Apr 09; 6(1). PMID: 35393508    Free PMC article.
Review.
Characteristics of immunophenotypes and immunological in tumor microenvironment and analysis of immune implication of CXCR4 in gastric cancer.
Fang Wen, Xiaona Lu, +8 authors, Peng Shu.
Sci Rep, 2022 Apr 08; 12(1). PMID: 35388021    Free PMC article.
Immunomodulatory Properties of Immune Checkpoint Inhibitors-More than Boosting T-Cell Responses?
Michael Kuske, Maximilian Haist, +2 authors, Matthias Bros.
Cancers (Basel), 2022 Apr 13; 14(7). PMID: 35406483    Free PMC article.
Review.
Emerging Strategies in TCR-Engineered T Cells.
Fang Wei, Xiao-Xia Cheng, John Zhao Xue, Shao-An Xue.
Front Immunol, 2022 Apr 19; 13. PMID: 35432319    Free PMC article.
Review.
Inhibitory Immune Checkpoint Receptors and Ligands as Prognostic Biomarkers in COVID-19 Patients.
Mohammad A Al-Mterin, Alhasan Alsalman, Eyad Elkord.
Front Immunol, 2022 Apr 19; 13. PMID: 35432324    Free PMC article.
Review.
Novel Immunotherapies for Osteosarcoma.
Yubao Lu, Jiahe Zhang, +4 authors, Cangyu Zhang.
Front Oncol, 2022 Apr 19; 12. PMID: 35433427    Free PMC article.
Review.
Immunolocalization of CD80 and CD86 in Non-Small Cell Lung Carcinoma: CD80 as a Potent Prognostic Factor.
Takashi Sato, Kiyoshi Takagi, +7 authors, Hiroshi Hojo.
Acta Histochem Cytochem, 2022 Apr 22; 55(1). PMID: 35444349    Free PMC article.
Development and Validation of Novel Prognostic Models for Immune-Related Genes in Osteosarcoma.
Junqing Li, Li Su, +6 authors, Huimin Zhu.
Front Mol Biosci, 2022 Apr 26; 9. PMID: 35463956    Free PMC article.
Anti-Th17 and anti-Th2 responses effects of hydro-ethanolic extracts of Aframomum melegueta, Khaya senegalensis and Xylopia aethiopica in hyperreactive onchocerciasis individuals' peripheral blood mononuclear cells.
Gnatoulma Katawa, Essoham Ataba, +12 authors, Laura E Layland.
PLoS Negl Trop Dis, 2022 Apr 26; 16(4). PMID: 35468134    Free PMC article.
Interleukin‑27 ameliorates allergic asthma by alleviating the lung Th2 inflammatory environment.
Jiameng Lu, Xiaoqing Ji, +8 authors, Degan Lu.
Int J Mol Med, 2022 May 07; 49(6). PMID: 35514302    Free PMC article.
Immune microenvironment characteristics and their implications for immune checkpoint inhibitor efficacy in HER2-overexpressing gastric cancer.
Shuyi Cen, Haimiao Xu, +3 authors, Weidong Han.
Clin Exp Immunol, 2022 May 14; 207(3). PMID: 35553632    Free PMC article.
Emerging immunotherapy for HCC: A guide for hepatologists.
Friedrich Foerster, Simon Johannes Gairing, Sumera Irie Ilyas, Peter Robert Galle.
Hepatology, 2022 Mar 08; 75(6). PMID: 35253934    Free PMC article.
Review.
The importance of N6-methyladenosine modification in tumor immunity and immunotherapy.
Ze Zhang, Furong Liu, +6 authors, Zhanguo Zhang.
Exp Hematol Oncol, 2022 May 20; 11(1). PMID: 35590394    Free PMC article.
Review.
Analysis of interactions of immune checkpoint inhibitors with antibiotics in cancer therapy.
Yingying Li, Shiyuan Wang, +3 authors, Guohui Li.
Front Med, 2022 Jun 02;. PMID: 35648368
Review.