Journal Article
. 2017 Dec; 7(1):16878.
doi: 10.1038/s41598-017-17204-5.

QuPath: Open source software for digital pathology image analysis

Peter Bankhead 1 Maurice B Loughrey 1 José A Fernández 1 Yvonne Dombrowski 2 Darragh G McArt 1 Philip D Dunne 1 Stephen McQuaid 1 Ronan T Gray 3 Liam J Murray 3 Helen G Coleman 3 Jacqueline A James 1 Manuel Salto-Tellez 4 Peter W Hamilton 5 
Affiliations
  • PMID: 29203879
  •     30 References
  •     659 citations

Abstract

QuPath is new bioimage analysis software designed to meet the growing need for a user-friendly, extensible, open-source solution for digital pathology and whole slide image analysis. In addition to offering a comprehensive panel of tumor identification and high-throughput biomarker evaluation tools, QuPath provides researchers with powerful batch-processing and scripting functionality, and an extensible platform with which to develop and share new algorithms to analyze complex tissue images. Furthermore, QuPath's flexible design makes it suitable for a wide range of additional image analysis applications across biomedical research.

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Claudia Mazo, Estibaliz Orue-Etxebarria, +3 authors, Andoni Beristain.
Cancers (Basel), 2018 Dec 19; 10(12). PMID: 30558303    Free PMC article.
Predicting survival from colorectal cancer histology slides using deep learning: A retrospective multicenter study.
Jakob Nikolas Kather, Johannes Krisam, +15 authors, Niels Halama.
PLoS Med, 2019 Jan 25; 16(1). PMID: 30677016    Free PMC article.
Highly Cited.
An actionable axis linking NFATc2 to EZH2 controls the EMT-like program of melanoma cells.
Valentina Perotti, Paola Baldassari, +8 authors, Roberta Mortarini.
Oncogene, 2019 Feb 03; 38(22). PMID: 30710146    Free PMC article.
Altered human oligodendrocyte heterogeneity in multiple sclerosis.
Sarah Jäkel, Eneritz Agirre, +7 authors, Gonçalo Castelo-Branco.
Nature, 2019 Feb 13; 566(7745). PMID: 30747918    Free PMC article.
Highly Cited.
The use of digital pathology and image analysis in clinical trials.
Robert Pell, Karin Oien, +6 authors, UK National Cancer Research Institute (NCRI) Cellular-Molecular Pathology (CM-Path) quality assurance working group.
J Pathol Clin Res, 2019 Feb 16; 5(2). PMID: 30767396    Free PMC article.
Evaluation of apoptosis imaging biomarkers in a genetic model of cell death.
Vessela Vassileva, Stephen M Stribbling, +11 authors, Eric O Aboagye.
EJNMMI Res, 2019 Feb 21; 9(1). PMID: 30783791    Free PMC article.
OTULIN deficiency in ORAS causes cell type-specific LUBAC degradation, dysregulated TNF signalling and cell death.
Rune Busk Damgaard, Paul R Elliott, +5 authors, Yackov Berkun.
EMBO Mol Med, 2019 Feb 26; 11(3). PMID: 30804083    Free PMC article.
A Syngeneic ErbB2 Mammary Cancer Model for Preclinical Immunotherapy Trials.
Zsófia Pénzváltó, Jane Qian Chen, +5 authors, Alexander D Borowsky.
J Mammary Gland Biol Neoplasia, 2019 Feb 28; 24(2). PMID: 30810966    Free PMC article.
p53 expression status is associated with cancer-specific survival in stage III and high-risk stage II colorectal cancer patients treated with oxaliplatin-based adjuvant chemotherapy.
Hyeon Jeong Oh, Jeong Mo Bae, +8 authors, Gyeong Hoon Kang.
Br J Cancer, 2019 Mar 22; 120(8). PMID: 30894685    Free PMC article.
Exome and immune cell score analyses reveal great variation within synchronous primary colorectal cancers.
Ulrika A Hänninen, Erkki-Ville Wirta, +13 authors, Lauri A Aaltonen.
Br J Cancer, 2019 Mar 22; 120(9). PMID: 30894686    Free PMC article.
The proportion of alveolar type 1 cells decreases in murine hypoplastic congenital diaphragmatic hernia lungs.
Tram Mai Nguyen, Julio Jimenez, +4 authors, Jaan Toelen.
PLoS One, 2019 Apr 18; 14(4). PMID: 30995255    Free PMC article.
Role of ectodysplasin signalling in middle ear and nasal pathology in rat and mouse models of hypohidrotic ectodermal dysplasia.
Jorge Del-Pozo, Neil MacIntyre, +3 authors, Michael Cheeseman.
Dis Model Mech, 2019 Apr 28; 12(4). PMID: 31028034    Free PMC article.
RB1 Deletion in Retinoblastoma Protein Pathway-Disrupted Cells Results in DNA Damage and Cancer Progression.
Aren E Marshall, Michael V Roes, +5 authors, Frederick A Dick.
Mol Cell Biol, 2019 May 30; 39(16). PMID: 31138663    Free PMC article.
Histone H3K27 dimethyl loss is highly specific for malignant peripheral nerve sheath tumor and distinguishes true PRC2 loss from isolated H3K27 trimethyl loss.
Dylan M Marchione, Amanda Lisby, +8 authors, John B Wojcik.
Mod Pathol, 2019 Jun 09; 32(10). PMID: 31175328    Free PMC article.
p73 regulates epidermal wound healing and induced keratinocyte programming.
J Scott Beeler, Clayton B Marshall, +8 authors, Jennifer A Pietenpol.
PLoS One, 2019 Jun 20; 14(6). PMID: 31216312    Free PMC article.
Comparative Transcriptomic Analysis of Temozolomide Resistant Primary GBM Stem-Like Cells and Recurrent GBM Identifies Up-Regulation of the Carbonic Anhydrase CA2 Gene as Resistance Factor.
Ricarda Hannen, Martin Selmansberger, +7 authors, Jörg Walter Bartsch.
Cancers (Basel), 2019 Jul 03; 11(7). PMID: 31262047    Free PMC article.
PD-1 and PD-L1 expression in pulmonary carcinoid tumors and their association to tumor spread.
Tiina Vesterinen, Teijo Kuopio, +5 authors, Caj Haglund.
Endocr Connect, 2019 Jul 13; 8(8). PMID: 31299636    Free PMC article.
Heterogeneity of PD-L1 expression in non-small cell lung cancer: Implications for specimen sampling in predicting treatment response.
Alexander Haragan, John K Field, +3 authors, John R Gosney.
Lung Cancer, 2019 Jul 20; 134. PMID: 31320000    Free PMC article.
Single-Cell Analysis of Crohn's Disease Lesions Identifies a Pathogenic Cellular Module Associated with Resistance to Anti-TNF Therapy.
Jerome C Martin, Christie Chang, +28 authors, Ephraim Kenigsberg.
Cell, 2019 Sep 03; 178(6). PMID: 31474370    Free PMC article.
Highly Cited.
Identification of the PTEN-ARID4B-PI3K pathway reveals the dependency on ARID4B by PTEN-deficient prostate cancer.
Ray-Chang Wu, In-Chi Young, +3 authors, Mei-Yi Wu.
Nat Commun, 2019 Sep 26; 10(1). PMID: 31551414    Free PMC article.
Syngeneic animal models of tobacco-associated oral cancer reveal the activity of in situ anti-CTLA-4.
Zhiyong Wang, Victoria H Wu, +16 authors, J Silvio Gutkind.
Nat Commun, 2019 Dec 06; 10(1). PMID: 31804466    Free PMC article.
Gemcitabine Recruits M2-Type Tumor-Associated Macrophages into the Stroma of Pancreatic Cancer.
Ashenafi Bulle, Jeroen Dekervel, +10 authors, Jos van Pelt.
Transl Oncol, 2020 Mar 08; 13(3). PMID: 32145636    Free PMC article.
Increased CD8 Tumor Infiltrating Lymphocytes in Colorectal Cancer Microenvironment Supports an Adaptive Immune Resistance Mechanism of PD-L1 Expression.
Aru W Sudoyo, Antonius N Kurniawan, +7 authors, Ahmad R Utomo.
Asian Pac J Cancer Prev, 2019 Nov 25; 20(11). PMID: 31759368    Free PMC article.
Artificial intelligence-guided tissue analysis combined with immune infiltrate assessment predicts stage III colon cancer outcomes in PETACC08 study.
Cynthia Reichling, Julien Taieb, +18 authors, François Ghiringhelli.
Gut, 2019 Nov 30; 69(4). PMID: 31780575    Free PMC article.
Deep learning pathological microscopic features in endemic nasopharyngeal cancer: Prognostic value and protentional role for individual induction chemotherapy.
Kuiyuan Liu, Weixiong Xia, +4 authors, Xing Lv.
Cancer Med, 2019 Dec 21; 9(4). PMID: 31860791    Free PMC article.
Severe hydroxymethylbilane synthase deficiency causes depression-like behavior and mitochondrial dysfunction in a mouse model of homozygous dominant acute intermittent porphyria.
Stefanie Berger, Miranda Stattmann, +9 authors, Daniela D Pollak.
Acta Neuropathol Commun, 2020 Mar 22; 8(1). PMID: 32197664    Free PMC article.
Feeding-dependent VIP neuron-ILC3 circuit regulates the intestinal barrier.
Jhimmy Talbot, Paul Hahn, +3 authors, Dan R Littman.
Nature, 2020 Feb 13; 579(7800). PMID: 32050257    Free PMC article.
Tumoral and immune heterogeneity in an anti-PD-1-responsive glioblastoma: a case study.
Paula Restrepo, Raymund Yong, +7 authors, Bojan Losic.
Cold Spring Harb Mol Case Stud, 2020 Jan 08; 6(2). PMID: 31907277    Free PMC article.
Adaptive RSK-EphA2-GPRC5A signaling switch triggers chemotherapy resistance in ovarian cancer.
Lidia Moyano-Galceran, Elina A Pietilä, +13 authors, Kaisa Lehti.
EMBO Mol Med, 2020 Mar 03; 12(4). PMID: 32115889    Free PMC article.
Maintaining protein stability of ∆Np63 via USP28 is required by squamous cancer cells.
Cristian Prieto-Garcia, Oliver Hartmann, +13 authors, Markus E Diefenbacher.
EMBO Mol Med, 2020 Mar 05; 12(4). PMID: 32128997    Free PMC article.
Granule Cell Dispersion in Human Temporal Lobe Epilepsy: Proteomics Investigation of Neurodevelopmental Migratory Pathways.
Joan Y W Liu, Natasha Dzurova, +3 authors, Maria Thom.
Front Cell Neurosci, 2020 Apr 08; 14. PMID: 32256318    Free PMC article.
Treatment-Induced Tumor Dormancy through YAP-Mediated Transcriptional Reprogramming of the Apoptotic Pathway.
Kari J Kurppa, Yao Liu, +41 authors, Pasi A Jänne.
Cancer Cell, 2020 Jan 15; 37(1). PMID: 31935369    Free PMC article.
NTP42, a novel antagonist of the thromboxane receptor, attenuates experimentally induced pulmonary arterial hypertension.
Eamon P Mulvaney, Helen M Reid, +3 authors, B Therese Kinsella.
BMC Pulm Med, 2020 Apr 08; 20(1). PMID: 32252727    Free PMC article.
Protein Expression in Metastatic Melanoma and the Link to Disease Presentation in a Range of Tumor Phenotypes.
Yonghyo Kim, Jeovanis Gil, +17 authors, György Marko-Varga.
Cancers (Basel), 2020 Mar 28; 12(3). PMID: 32213878    Free PMC article.
Cep55 promotes cytokinesis of neural progenitors but is dispensable for most mammalian cell divisions.
Antonio Tedeschi, Jorge Almagro, +3 authors, Mark Petronczki.
Nat Commun, 2020 Apr 10; 11(1). PMID: 32269212    Free PMC article.
Human Pancreatic Carcinoma-Associated Fibroblasts Promote Expression of Co-inhibitory Markers on CD4+ and CD8+ T-Cells.
Laia Gorchs, Carlos Fernández Moro, +5 authors, Helen Kaipe.
Front Immunol, 2019 May 10; 10. PMID: 31068935    Free PMC article.
Association Between Toll-Like Receptor 4 (TLR4) and Triggering Receptor Expressed on Myeloid Cells 2 (TREM2) Genetic Variants and Clinical Progression of Huntington's Disease.
Romina Vuono, Antonina Kouli, +7 authors, Janelle Drouin-Ouellet.
Mov Disord, 2019 Nov 15; 35(3). PMID: 31724242    Free PMC article.
Correlation of imaging and histopathology of thrombi in acute ischemic stroke with etiology and outcome: a systematic review.
Waleed Brinjikji, Sharon Duffy, +11 authors, David F Kallmes.
J Neurointerv Surg, 2016 May 12; 9(6). PMID: 27166383    Free PMC article.
Systematic Review.
Combination immunotherapy and radiotherapy causes an abscopal treatment response in a mouse model of castration resistant prostate cancer.
Stephanie O Dudzinski, Brent D Cameron, +3 authors, Austin N Kirschner.
J Immunother Cancer, 2019 Aug 16; 7(1). PMID: 31412954    Free PMC article.
The molecular landscape and microenvironment of salivary duct carcinoma reveal new therapeutic opportunities.
Melissa Alame, Emmanuel Cornillot, +11 authors, Jacques Colinge.
Theranostics, 2020 Apr 16; 10(10). PMID: 32292502    Free PMC article.
Expression of immune checkpoint receptors Indoleamine 2,3-dioxygenase and T cell Ig and ITIM domain in metastatic versus nonmetastatic choroidal melanoma.
Gustav Stålhammar, Stefan Seregard, Hans E Grossniklaus.
Cancer Med, 2019 Apr 18; 8(6). PMID: 30993893    Free PMC article.
Combination of L1 methylation and tumor-infiltrating lymphocytes as prognostic marker in advanced gastric cancer.
Younghoon Kim, Ye-Young Rhee, +4 authors, Gyeong Hoon Kang.
Gastric Cancer, 2019 Nov 07; 23(3). PMID: 31691036
Automated Tumour Recognition and Digital Pathology Scoring Unravels New Role for PD-L1 in Predicting Good Outcome in ER-/HER2+ Breast Cancer.
Matthew P Humphries, Sean Hynes, +13 authors, Niamh E Buckley.
J Oncol, 2019 Jan 18; 2018. PMID: 30651729    Free PMC article.
Overview of multiplex immunohistochemistry/immunofluorescence techniques in the era of cancer immunotherapy.
Wei Chang Colin Tan, Sanjna Nilesh Nerurkar, +6 authors, Tony Kiat Hon Lim.
Cancer Commun (Lond), 2020 Apr 18; 40(4). PMID: 32301585    Free PMC article.
Review.
Autologous micrograft accelerates endogenous wound healing response through ERK-induced cell migration.
Martina Balli, Francesca Vitali, +13 authors, Maurilio Sampaolesi.
Cell Death Differ, 2019 Oct 28; 27(5). PMID: 31654035    Free PMC article.
Predominant Distribution of the RNAi Machinery at Apical Adherens Junctions in Colonic Epithelia Is Disrupted in Cancer.
Joyce Nair-Menon, Amanda C Daulagala, +8 authors, Antonis Kourtidis.
Int J Mol Sci, 2020 Apr 11; 21(7). PMID: 32272708    Free PMC article.
Oncogenic ALK drives tumorigenesis in cutaneous squamous cell carcinoma.
Marco Gualandi, Maria Iorio, +5 authors, Olga Shakhova.
Life Sci Alliance, 2020 Apr 22; 3(6). PMID: 32312912    Free PMC article.
Targeting CD47 in Anaplastic Thyroid Carcinoma Enhances Tumor Phagocytosis by Macrophages and Is a Promising Therapeutic Strategy.
Christian M Schürch, Matthias A Roelli, +11 authors, Matthias S Dettmer.
Thyroid, 2019 Apr 03; 29(7). PMID: 30938231    Free PMC article.
T lymphocytes and cytotoxic astrocyte blebs correlate across autism brains.
Marcello M DiStasio, Ikue Nagakura, Monica J Nadler, Matthew P Anderson.
Ann Neurol, 2019 Oct 09; 86(6). PMID: 31591744    Free PMC article.
Enhancing the Value of Histopathological Assessment of Allograft Biopsy Monitoring.
Michelle A Wood-Trageser, Andrew J Lesniak, Anthony J Demetris.
Transplantation, 2019 Feb 16; 103(7). PMID: 30768568    Free PMC article.
Review.
CK14 Expression Identifies a Basal/Squamous-Like Type of Papillary Non-Muscle-Invasive Upper Tract Urothelial Carcinoma.
Minsun Jung, Insoon Jang, Kwangsoo Kim, Kyung Chul Moon.
Front Oncol, 2020 May 12; 10. PMID: 32391279    Free PMC article.
The Fully human anti-CD47 antibody SRF231 exerts dual-mechanism antitumor activity via engagement of the activating receptor CD32a.
Marisa O Peluso, Ammar Adam, +10 authors, Alison M Paterson.
J Immunother Cancer, 2020 Apr 30; 8(1). PMID: 32345627    Free PMC article.
Safety and Activity of the Combination of Ceritinib and Dasatinib in Osteosarcoma.
Olaf Beck, Claudia Paret, +19 authors, Joerg Faber.
Cancers (Basel), 2020 Apr 01; 12(4). PMID: 32224911    Free PMC article.
Identification and Validation of VEGFR2 Kinase as a Target of Voacangine by a Systematic Combination of DARTS and MSI.
Yonghyo Kim, Yutaka Sugihara, +11 authors, Ho Jeong Kwon.
Biomolecules, 2020 Apr 02; 10(4). PMID: 32230857    Free PMC article.
Application of a risk-management framework for integration of stromal tumor-infiltrating lymphocytes in clinical trials.
Jan Hudeček, Leonie Voorwerk, +29 authors, International Immuno-Oncology Biomarker Working Group.
NPJ Breast Cancer, 2020 May 22; 6. PMID: 32436923    Free PMC article.
Review.
Is Optogenetic Activation of Vglut1-Positive Aβ Low-Threshold Mechanoreceptors Sufficient to Induce Tactile Allodynia in Mice after Nerve Injury?
Alexander Chamessian, Megumi Matsuda, +7 authors, Ru-Rong Ji.
J Neurosci, 2019 Jun 04; 39(31). PMID: 31152125    Free PMC article.
Deep-Learning-Based Characterization of Tumor-Infiltrating Lymphocytes in Breast Cancers From Histopathology Images and Multiomics Data.
Zixiao Lu, Siwen Xu, +5 authors, Kun Huang.
JCO Clin Cancer Inform, 2020 May 27; 4. PMID: 32453636    Free PMC article.
A novel pancreatic tumour and stellate cell 3D co-culture spheroid model.
K J Norberg, X Liu, +7 authors, J M Löhr.
BMC Cancer, 2020 May 29; 20(1). PMID: 32460715    Free PMC article.
89Zr-PET imaging of DNA double-strand breaks for the early monitoring of response following α- and β-particle radioimmunotherapy in a mouse model of pancreatic ductal adenocarcinoma.
Sophie Poty, Komal Mandleywala, +3 authors, Jason S Lewis.
Theranostics, 2020 Jun 03; 10(13). PMID: 32483420    Free PMC article.
Protective role of B cells in sterile particulate-induced lung injury.
Shaikh M Atif, Douglas G Mack, +7 authors, Andrew P Fontenot.
JCI Insight, 2019 May 17; 5. PMID: 31094704    Free PMC article.
Multi-Spheroid-Loaded Human Acellular Dermal Matrix Carrier Preserves Its Spheroid Shape and Improves In Vivo Adipose-Derived Stem Cell Delivery and Engraftment.
Jie Hyun Kim, Jun Yong Lee.
Tissue Eng Regen Med, 2020 Apr 22; 17(3). PMID: 32314311    Free PMC article.
Single-nucleus RNA sequencing of mouse auditory cortex reveals critical period triggers and brakes.
Brian T Kalish, Tania R Barkat, +3 authors, Takao K Hensch.
Proc Natl Acad Sci U S A, 2020 May 15; 117(21). PMID: 32404418    Free PMC article.
The adaptive immune and immune checkpoint landscape of neoadjuvant treated esophageal adenocarcinoma using digital pathology quantitation.
Matthew P Humphries, Stephanie G Craig, +8 authors, Manuel Salto-Tellez.
BMC Cancer, 2020 Jun 04; 20(1). PMID: 32487090    Free PMC article.
A missense mutation of ErbB2 produces a novel mouse model of stillbirth associated with a cardiac abnormality but lacking abnormalities of placental structure.
Heba Shawer, Esther Aiyelaagbe, +7 authors, Alexander E P Heazell.
PLoS One, 2020 Jun 04; 15(6). PMID: 32492036    Free PMC article.
Focused ultrasound for safe and effective release of brain tumor biomarkers into the peripheral circulation.
Lifei Zhu, Arash Nazeri, +2 authors, Hong Chen.
PLoS One, 2020 Jun 04; 15(6). PMID: 32492056    Free PMC article.
Novel morphological multi-scale evaluation system for quality assessment of decellularized liver scaffolds.
Vladimíra Moulisová, Miroslav Jiřík, +9 authors, Uta Dahmen.
J Tissue Eng, 2020 Jun 12; 11. PMID: 32523667    Free PMC article.
HISTOBREAST, a collection of brightfield microscopy images of Haematoxylin and Eosin stained breast tissue.
Roxana M Buga, Tiberiu Totu, +4 authors, Stefan G Stanciu.
Sci Data, 2020 Jun 07; 7(1). PMID: 32503988    Free PMC article.
A Machine-learning Approach for the Assessment of the Proliferative Compartment of Solid Tumors on Hematoxylin-Eosin-Stained Sections.
Francesco Martino, Silvia Varricchio, +11 authors, Stefania Staibano.
Cancers (Basel), 2020 May 30; 12(5). PMID: 32466184    Free PMC article.
Improving the Diagnostic Accuracy of the PD-L1 Test with Image Analysis and Multiplex Hybridization.
Matthew P Humphries, Victoria Bingham, +4 authors, Manuel Salto-Tellez.
Cancers (Basel), 2020 May 06; 12(5). PMID: 32365629    Free PMC article.
Identification of a novel IL-5 signaling pathway in chronic pancreatitis and crosstalk with pancreatic tumor cells.
Sarah B Gitto, Jordan M Beardsley, +8 authors, Deborah A Altomare.
Cell Commun Signal, 2020 Jun 20; 18(1). PMID: 32552827    Free PMC article.
Combined deletion of Glut1 and Glut3 impairs lung adenocarcinoma growth.
Caroline Contat, Pierre-Benoit Ancey, +18 authors, Etienne Meylan.
Elife, 2020 Jun 24; 9. PMID: 32571479    Free PMC article.
Based on Histogram Analysis: ADCaqp Derived from Ultra-high b-Value DWI could be a Non-invasive Specific Biomarker for Rectal Cancer Prognosis.
Guangwen Zhang, Wanling Ma, +7 authors, Jinsong Zhang.
Sci Rep, 2020 Jun 25; 10(1). PMID: 32576929    Free PMC article.
Bidirectional pharmacological perturbations of the noradrenergic system differentially affect tactile detection.
Jim McBurney-Lin, Yina Sun, +3 authors, Hongdian Yang.
Neuropharmacology, 2020 May 24; 174. PMID: 32445638    Free PMC article.
Quantitative patterns of motor cortex proteinopathy across ALS genotypes.
Matthew Nolan, Connor Scott, +9 authors, Olaf Ansorge.
Acta Neuropathol Commun, 2020 Jul 04; 8(1). PMID: 32616036    Free PMC article.
An integrative histopathologic clustering model based on immuno-matrix elements to predict the risk of death in malignant mesothelioma.
Marcelo Luiz Balancin, Walcy Rosolia Teodoro, +8 authors, Vera Luiza Capelozzi.
Cancer Med, 2020 May 12; 9(13). PMID: 32391978    Free PMC article.
The E3 ligase HUWE1 inhibition as a therapeutic strategy to target MYC in multiple myeloma.
Lisa J Crawford, David C Campbell, +10 authors, Alexandra E Irvine.
Oncogene, 2020 Jun 12; 39(27). PMID: 32523091    Free PMC article.
Temporospatial shifts within commercial laboratory mouse gut microbiota impact experimental reproducibility.
Rabindra K Mandal, Joshua E Denny, +7 authors, Nathan W Schmidt.
BMC Biol, 2020 Jul 06; 18(1). PMID: 32620114    Free PMC article.
Integrin alpha-5 silencing leads to myofibroblastic differentiation in IPF-derived human lung fibroblasts.
Gali Epstein Shochet, Elizabetha Brook, +4 authors, David Shitrit.
Ther Adv Chronic Dis, 2020 Jul 09; 11. PMID: 32637060    Free PMC article.
Does multiparametric imaging with 18F-FDG-PET/MRI capture spatial variation in immunohistochemical cancer biomarkers in head and neck squamous cell carcinoma?
Jacob H Rasmussen, Anders Olin, +10 authors, Barbara M Fischer.
Br J Cancer, 2020 May 10; 123(1). PMID: 32382113    Free PMC article.
NCLX prevents cell death during adrenergic activation of the brown adipose tissue.
Essam A Assali, Anthony E Jones, +9 authors, Orian S Shirihai.
Nat Commun, 2020 Jul 06; 11(1). PMID: 32620768    Free PMC article.
The Dysfunctional Immune System in Common Variable Immunodeficiency Increases the Susceptibility to Gastric Cancer.
Irene Gullo, Catarina Costa, +14 authors, Ana E Sousa.
Cells, 2020 Jun 25; 9(6). PMID: 32575504    Free PMC article.
Effect of meloxicam (cyclooygenase-2 inhibitor) versus vitamin D3 (cholecalciferol) as ameliorating agents of progressive doxorubicin-induced nephrotoxicity in rats.
Dalia Mahmoud Abdelmonem Elsherbini, Hasnaa Ali Ebrahim.
Anat Cell Biol, 2020 Jul 11; 53(2). PMID: 32647085    Free PMC article.
Histological validation of in vivo assessment of cancer tissue inhomogeneity and automated morphological segmentation enabled by Optical Coherence Elastography.
Anton A Plekhanov, Marina A Sirotkina, +7 authors, Vladimir Y Zaitsev.
Sci Rep, 2020 Jul 18; 10(1). PMID: 32678175    Free PMC article.
Alignment of stroma fibers, microvessel density and immune cell populations determine overall survival in pancreatic cancer-An analysis of stromal morphology.
Louisa Bolm, Petro Zghurskyi, +8 authors, Ulrich F Wellner.
PLoS One, 2020 Jul 14; 15(7). PMID: 32658932    Free PMC article.
Cytological and microbiological characteristics of middle ear effusions in brachycephalic dogs.
Elspeth Milne, Tim Nuttall, +6 authors, Michael Cheeseman.
J Vet Intern Med, 2020 May 15; 34(4). PMID: 32407559    Free PMC article.
Prognostic potential of automated Ki67 evaluation in breast cancer: different hot spot definitions versus true global score.
Stephanie Robertson, Balazs Acs, Michael Lippert, Johan Hartman.
Breast Cancer Res Treat, 2020 Jun 24; 183(1). PMID: 32572716    Free PMC article.
QuPath Automated Analysis of Optic Nerve Degeneration in Brown Norway Rats.
Barbara A Mysona, Sharmila Segar, +4 authors, Kathryn E Bollinger.
Transl Vis Sci Technol, 2020 Jul 28; 9(3). PMID: 32714648    Free PMC article.
Sequential immunohistochemistry and virtual image reconstruction using a single slide for quantitative KI67 measurement in breast cancer.
Garazi Serna, Sara Simonetti, +10 authors, Paolo Nuciforo.
Breast, 2020 Jul 25; 53. PMID: 32707454    Free PMC article.
Single-transcript multiplex in situ hybridisation reveals unique patterns of dystrophin isoform expression in the developing mammalian embryo.
John C W Hildyard, Abbe H Crawford, +3 authors, Richard J Piercy.
Wellcome Open Res, 2020 Aug 01; 5. PMID: 32724863    Free PMC article.
Evaluation of the Efficacy of the Brucella canis RM6/66 ΔvjbR Vaccine Candidate for Protection against B. canis Infection in Mice.
Lauren W Stranahan, Sankar P Chaki, +2 authors, Angela M Arenas-Gamboa.
mSphere, 2020 May 22; 5(3). PMID: 32434839    Free PMC article.
Correlation of MET and PD-L1 Expression in Malignant Melanoma.
Kyu Young Song, Sabina Desar, +2 authors, Alessio Giubellino.
Cancers (Basel), 2020 Jul 15; 12(7). PMID: 32659961    Free PMC article.
A deep learning model to predict RNA-Seq expression of tumours from whole slide images.
Benoît Schmauch, Alberto Romagnoni, +11 authors, Gilles Wainrib.
Nat Commun, 2020 Aug 05; 11(1). PMID: 32747659    Free PMC article.
Muscarinic receptors promote castration-resistant growth of prostate cancer through a FAK-YAP signaling axis.
Yusuke Goto, Toshinori Ando, +6 authors, J Silvio Gutkind.
Oncogene, 2020 Mar 25; 39(20). PMID: 32205868    Free PMC article.
Prognostic Significance of Immune Cell Populations Identified by Machine Learning in Colorectal Cancer Using Routine Hematoxylin and Eosin-Stained Sections.
Juha P Väyrynen, Mai Chan Lau, +24 authors, Jonathan A Nowak.
Clin Cancer Res, 2020 May 23; 26(16). PMID: 32439699    Free PMC article.
Cytotoxicity of the effector protein BteA was attenuated in Bordetella pertussis by insertion of an alanine residue.
Jan Bayram, Ivana Malcova, +7 authors, Jana Kamanova.
PLoS Pathog, 2020 Aug 11; 16(8). PMID: 32776984    Free PMC article.
Evidence for Recipient-Derived Cells in Peribiliary Glands and Biliary Epithelium of the Large Donor Bile Ducts After Liver Transplantation.
Iris E M de Jong, Michael E Sutton, +2 authors, Robert J Porte.
Front Cell Dev Biol, 2020 Aug 28; 8. PMID: 32850815    Free PMC article.
Comparative Analysis of the Development of Acquired Radioresistance in Canine and Human Mammary Cancer Cell Lines.
Mark Gray, Arran K Turnbull, +4 authors, David J Argyle.
Front Vet Sci, 2020 Aug 28; 7. PMID: 32851022    Free PMC article.
Lower peripheral helper T cell levels in the synovium are associated with a better response to anti-TNF therapy in rheumatoid arthritis.
Antonio Julià, Gabriela Ávila, +4 authors, Juan D Cañete.
Arthritis Res Ther, 2020 Aug 28; 22(1). PMID: 32843099    Free PMC article.
Discovering New Lipidomic Features Using Cell Type Specific Fluorophore Expression to Provide Spatial and Biological Specificity in a Multimodal Workflow with MALDI Imaging Mass Spectrometry.
Marissa A Jones, Sung Hoon Cho, +4 authors, Richard M Caprioli.
Anal Chem, 2020 Apr 17; 92(10). PMID: 32298091    Free PMC article.
Acellular Biologic Nipple-Areolar Complex Graft: In Vivo Murine and Nonhuman Primate Host Response Evaluation.
Nicholas C Pashos, David M Graham, +12 authors, Bruce A Bunnell.
Tissue Eng Part A, 2020 Jan 18; 26(15-16). PMID: 31950890    Free PMC article.
Prognostic Value of Immune Environment Analysis in Small Bowel Adenocarcinomas with Verified Mutational Landscape and Predisposing Conditions.
Erkki-Ville Wirta, Säde Szeto, +5 authors, Toni T Seppälä.
Cancers (Basel), 2020 Jul 29; 12(8). PMID: 32718028    Free PMC article.
Impact of rescanning and normalization on convolutional neural network performance in multi-center, whole-slide classification of prostate cancer.
Zaneta Swiderska-Chadaj, Thomas de Bel, +4 authors, Geert Litjens.
Sci Rep, 2020 Sep 03; 10(1). PMID: 32873856    Free PMC article.
Downstream neighbor of SON (DONSON) is associated with unfavorable survival across diverse cancers with oncogenic properties in clear cell renal cell carcinoma.
Niklas Klümper, Iulia Blajan, +5 authors, Jörg Ellinger.
Transl Oncol, 2020 Aug 18; 13(11). PMID: 32805676    Free PMC article.
Breast Cancer Histopathology Image Classification Using an Ensemble of Deep Learning Models.
Zabit Hameed, Sofia Zahia, +2 authors, Ana María Vanegas.
Sensors (Basel), 2020 Aug 09; 20(16). PMID: 32764398    Free PMC article.
Digital quantitative assessment of PD-L1 using digital spatial profiling.
Swati Gupta, Jon Zugazagoitia, +2 authors, David L Rimm.
Lab Invest, 2020 Apr 07; 100(10). PMID: 32249818    Free PMC article.
Altered Levels of Decidual Immune Cell Subsets in Fetal Growth Restriction, Stillbirth, and Placental Pathology.
Romy E Bezemer, Mirthe H Schoots, +5 authors, Jelmer R Prins.
Front Immunol, 2020 Sep 26; 11. PMID: 32973787    Free PMC article.
APOE and TREM2 regulate amyloid-responsive microglia in Alzheimer's disease.
Aivi T Nguyen, Kui Wang, +9 authors, Edward B Lee.
Acta Neuropathol, 2020 Aug 26; 140(4). PMID: 32840654    Free PMC article.
Twenty Years of Digital Pathology: An Overview of the Road Travelled, What is on the Horizon, and the Emergence of Vendor-Neutral Archives.
Liron Pantanowitz, Ashish Sharma, +3 authors, Joel Saltz.
J Pathol Inform, 2019 Jan 05; 9. PMID: 30607307    Free PMC article.
Review.
Laboratory Computer Performance in a Digital Pathology Environment: Outcomes from a Single Institution.
Mark D Zarella, Adam Feldscher.
J Pathol Inform, 2019 Jan 10; 9. PMID: 30622834    Free PMC article.
State-of-the-Art of Profiling Immune Contexture in the Era of Multiplexed Staining and Digital Analysis to Study Paraffin Tumor Tissues.
Edwin Roger Parra, Alejandro Francisco-Cruz, Ignacio Ivan Wistuba.
Cancers (Basel), 2019 Feb 23; 11(2). PMID: 30791580    Free PMC article.
Review.
The potential risk of tumor progression after use of dehydrated human amnion/chorion membrane allograft in a positive margin resection model.
Ricardo G Alvim, Christopher Hughes, +6 authors, Jonathan A Coleman.
Ther Adv Urol, 2019 Apr 09; 11. PMID: 30956688    Free PMC article.
Introduction to Digital Image Analysis in Whole-slide Imaging: A White Paper from the Digital Pathology Association.
Famke Aeffner, Mark D Zarella, +11 authors, Douglas Bowman.
J Pathol Inform, 2019 Apr 16; 10. PMID: 30984469    Free PMC article.
Highly Cited. Review.
Dual-Personality DICOM-TIFF for Whole Slide Images: A Migration Technique for Legacy Software.
David A Clunie.
J Pathol Inform, 2019 May 07; 10. PMID: 31057981    Free PMC article.
Digital Image Analysis of BAP-1 Accurately Predicts Uveal Melanoma Metastasis.
Gustav Stålhammar, Thonnie Rose O See, +2 authors, Hans E Grossniklaus.
Transl Vis Sci Technol, 2019 May 22; 8(3). PMID: 31110912    Free PMC article.
Empiric Methods to Account for Pre-analytical Variability in Digital Histopathology in Frontotemporal Lobar Degeneration.
Lucia A A Giannini, Sharon X Xie, +7 authors, David J Irwin.
Front Neurosci, 2019 Jul 25; 13. PMID: 31333403    Free PMC article.
CCR5 status and metastatic progression in colorectal cancer.
Meggy Suarez-Carmona, Pornpimol Chaorentong, +20 authors, Niels Halama.
Oncoimmunology, 2019 Aug 21; 8(9). PMID: 31428524    Free PMC article.
Cowpea Mosaic Virus Immunotherapy Combined with Cyclophosphamide Reduces Breast Cancer Tumor Burden and Inhibits Lung Metastasis.
Hui Cai, Chao Wang, Sourabh Shukla, Nicole F Steinmetz.
Adv Sci (Weinh), 2019 Aug 28; 6(16). PMID: 31453050    Free PMC article.
Multi-Field-of-View Deep Learning Model Predicts Nonsmall Cell Lung Cancer Programmed Death-Ligand 1 Status from Whole-Slide Hematoxylin and Eosin Images.
Lingdao Sha, Boleslaw L Osinski, +7 authors, Stephen S F Yip.
J Pathol Inform, 2019 Sep 17; 10. PMID: 31523482    Free PMC article.
TissUUmaps: interactive visualization of large-scale spatial gene expression and tissue morphology data.
Leslie Solorzano, Gabriele Partel, Carolina Wählby.
Bioinformatics, 2020 May 26; 36(15). PMID: 32449759    Free PMC article.
Osteopontin Expression Identifies a Subset of Recruited Macrophages Distinct from Kupffer Cells in the Fatty Liver.
Anneleen Remmerie, Liesbet Martens, +19 authors, Charlotte L Scott.
Immunity, 2020 Sep 06; 53(3). PMID: 32888418    Free PMC article.
High MHC-II expression in Epstein-Barr virus-associated gastric cancers suggests that tumor cells serve an important role in antigen presentation.
Farhad Ghasemi, Tanner M Tessier, +3 authors, Joe S Mymryk.
Sci Rep, 2020 Sep 10; 10(1). PMID: 32901107    Free PMC article.
Decorin expression is associated with predictive diffusion MR phenotypes of anti-VEGF efficacy in glioblastoma.
Kunal S Patel, Jingwen Yao, +12 authors, Benjamin M Ellingson.
Sci Rep, 2020 Sep 11; 10(1). PMID: 32908231    Free PMC article.
Doxorubicin Conjugation to Reovirus Improves Oncolytic Efficacy in Triple-Negative Breast Cancer.
Jameson T L Berry, Luis E Muñoz, +2 authors, Bernardo A Mainou.
Mol Ther Oncolytics, 2020 Oct 01; 18. PMID: 32995480    Free PMC article.
A robust multiplex immunofluorescence and digital pathology workflow for the characterisation of the tumour immune microenvironment.
Amélie Viratham Pulsawatdi, Stephanie G Craig, +10 authors, Manuel Salto-Tellez.
Mol Oncol, 2020 Jul 17; 14(10). PMID: 32671911    Free PMC article.
IL-32γ potentiates tumor immunity in melanoma.
Thomas Gruber, Mirela Kremenovic, +12 authors, Mirjam Schenk.
JCI Insight, 2020 Aug 26; 5(18). PMID: 32841222    Free PMC article.
Differential gene expression of tumor-infiltrating CD8+ T cells in advanced versus early-stage colorectal cancer and identification of a gene signature of poor prognosis.
Reem Saleh, Varun Sasidharan Nair, +8 authors, Eyad Elkord.
J Immunother Cancer, 2020 Sep 20; 8(2). PMID: 32948653    Free PMC article.
Morphometric Cell Classification for Single-Cell MALDI-Mass Spectrometry Imaging.
Klára Ščupáková, Frédéric Dewez, +2 authors, Benjamin Balluff.
Angew Chem Int Ed Engl, 2020 Jul 16; 59(40). PMID: 32668069    Free PMC article.
LibMI: An Open Source Library for Efficient Histopathological Image Processing.
Yuxin Dong, Pargorn Puttapirat, +2 authors, Chen Li.
J Pathol Inform, 2020 Oct 13; 11. PMID: 33042605    Free PMC article.
TissueWand, a Rapid Histopathology Annotation Tool.
Martin Lindvall, Alexander Sanner, +4 authors, Jonas Löwgren.
J Pathol Inform, 2020 Oct 13; 11. PMID: 33042606    Free PMC article.
Immune status is prognostic for poor survival in colorectal cancer patients and is associated with tumour hypoxia.
Stephanie G Craig, Matthew P Humphries, +21 authors, Manuel Salto-Tellez.
Br J Cancer, 2020 Jul 21; 123(8). PMID: 32684627    Free PMC article.
Predicting Metastatic Potential in Pheochromocytoma and Paraganglioma: A Comparison of PASS and GAPP Scoring Systems.
Heather Wachtel, Troy Hutchens, +9 authors, Lauren Fishbein.
J Clin Endocrinol Metab, 2020 Sep 03; 105(12). PMID: 32877928    Free PMC article.
Safety and efficacy of single cycle induction treatment with cisplatin/docetaxel/ durvalumab/tremelimumab in locally advanced HNSCC: first results of CheckRad-CD8.
Markus Hecht, Antoniu Oreste Gostian, +18 authors, Rainer Fietkau.
J Immunother Cancer, 2020 Oct 08; 8(2). PMID: 33023982    Free PMC article.
Immune contexture analysis in immuno-oncology: applications and challenges of multiplex fluorescent immunohistochemistry.
Reshma Shakya, Tam Hong Nguyen, Nigel Waterhouse, Rajiv Khanna.
Clin Transl Immunology, 2020 Oct 20; 9(10). PMID: 33072322    Free PMC article.
Review.
Islet transplantation in the subcutaneous space achieves long-term euglycaemia in preclinical models of type 1 diabetes.
Ming Yu, Divyansh Agarwal, +10 authors, Ali Naji.
Nat Metab, 2020 Sep 09; 2(10). PMID: 32895576    Free PMC article.
IgE Effector Mechanisms, in Concert with Mast Cells, Contribute to Acquired Host Defense against Staphylococcusaureus.
Philipp Starkl, Martin L Watzenboeck, +15 authors, Sylvia Knapp.
Immunity, 2020 Sep 11; 53(4). PMID: 32910906    Free PMC article.
Integration of geoscience frameworks into digital pathology analysis permits quantification of microarchitectural relationships in histological landscapes.
Timothy J Kendall, Catherine M Duff, Andrew M Thomson, John P Iredale.
Sci Rep, 2020 Oct 18; 10(1). PMID: 33067578    Free PMC article.
Imaging the Neuroimmune Dynamics Across Space and Time.
Micaël Carrier, Marie-Ève Robert, +2 authors, Marie-Ève Tremblay.
Front Neurosci, 2020 Oct 20; 14. PMID: 33071723    Free PMC article.
Review.
MarrowQuant Across Aging and Aplasia: A Digital Pathology Workflow for Quantification of Bone Marrow Compartments in Histological Sections.
Josefine Tratwal, David Bekri, +15 authors, Olaia Naveiras.
Front Endocrinol (Lausanne), 2020 Oct 20; 11. PMID: 33071956    Free PMC article.
Upregulation of lipid metabolism genes in the breast prior to cancer diagnosis.
Natascia Marino, Rana German, +9 authors, Anna Maria V Storniolo.
NPJ Breast Cancer, 2020 Oct 22; 6. PMID: 33083529    Free PMC article.
Clinical-Grade Detection of Microsatellite Instability in Colorectal Tumors by Deep Learning.
Amelie Echle, Heike Irmgard Grabsch, +20 authors, Jakob Nikolas Kather.
Gastroenterology, 2020 Jun 21; 159(4). PMID: 32562722    Free PMC article.
Proliferation of HIV-infected renal epithelial cells following virus acquisition from infected macrophages.
Kelly Hughes, Guray Akturk, +3 authors, Maria Blasi.
AIDS, 2020 Jul 24; 34(11). PMID: 32701578    Free PMC article.
Greater utility of molecular subtype rather than epithelial-to-mesenchymal transition (EMT) markers for prognosis in high-risk non-muscle-invasive (HGT1) bladder cancer.
Edward C Ottley, Robert Pell, +5 authors, Anne E Kiltie.
J Pathol Clin Res, 2020 May 07; 6(4). PMID: 32374509    Free PMC article.
Lineage tracing reveals evidence of a popliteal lymphatic muscle progenitor cell that is distinct from skeletal and vascular muscle progenitors.
H Mark Kenney, Richard D Bell, +3 authors, Edward M Schwarz.
Sci Rep, 2020 Oct 24; 10(1). PMID: 33093635    Free PMC article.
Unraveling spatial cellular pattern by computational tissue shuffling.
Elise Laruelle, Nathalie Spassky, Auguste Genovesio.
Commun Biol, 2020 Oct 25; 3(1). PMID: 33097821    Free PMC article.
Radiotherapy Scheme Effect on PD-L1 Expression for Locally Advanced Rectal Cancer.
Jihane Boustani, Valentin Derangère, +5 authors, Céline Mirjolet.
Cells, 2020 Sep 16; 9(9). PMID: 32927784    Free PMC article.
Image-to-image translation for automatic ink removal in whole slide images.
Jun Jiang, Naresh Prodduturi, +4 authors, Steven Hart.
J Med Imaging (Bellingham), 2020 Oct 27; 7(5). PMID: 33102624    Free PMC article.
Unacylated-Ghrelin Impairs Hippocampal Neurogenesis and Memory in Mice and Is Altered in Parkinson's Dementia in Humans.
Amanda K E Hornsby, Luke Buntwal, +15 authors, Jeffrey S Davies.
Cell Rep Med, 2020 Oct 27; 1(7). PMID: 33103129    Free PMC article.
WNT11-FZD7-DAAM1 signalling supports tumour initiating abilities and melanoma amoeboid invasion.
Irene Rodriguez-Hernandez, Oscar Maiques, +14 authors, Victoria Sanz-Moreno.
Nat Commun, 2020 Oct 22; 11(1). PMID: 33082334    Free PMC article.
Non-Muscle-Invasive Bladder Carcinoma with Respect to Basal Versus Luminal Keratin Expression.
Minsun Jung, Insoon Jang, Kwangsoo Kim, Kyung Chul Moon.
Int J Mol Sci, 2020 Oct 23; 21(20). PMID: 33086575    Free PMC article.
OpSeF: Open Source Python Framework for Collaborative Instance Segmentation of Bioimages.
Tobias M Rasse, Réka Hollandi, Peter Horvath.
Front Bioeng Biotechnol, 2020 Oct 30; 8. PMID: 33117778    Free PMC article.
Digital analysis of distant and cancer-associated mammary adipocytes.
Edoardo Isnaldi, François Richard, +12 authors, Christine Desmedt.
Breast, 2020 Oct 30; 54. PMID: 33120083    Free PMC article.
Stromal Expression of the Core Clock Gene Period 2 Is Essential for Tumor Initiation and Metastatic Colonization.
Lee Shaashua, Shimrit Mayer, +3 authors, Ruth Scherz-Shouval.
Front Cell Dev Biol, 2020 Oct 31; 8. PMID: 33123539    Free PMC article.
Combining multiple spatial statistics enhances the description of immune cell localisation within tumours.
Joshua A Bull, Philip S Macklin, +4 authors, Helen M Byrne.
Sci Rep, 2020 Oct 31; 10(1). PMID: 33122646    Free PMC article.
Metabolic characterization of human IDH mutant and wild type gliomas using simultaneous pH- and oxygen-sensitive molecular MRI.
Jingwen Yao, Ararat Chakhoyan, +12 authors, Benjamin M Ellingson.
Neuro Oncol, 2019 May 09; 21(9). PMID: 31066901    Free PMC article.
Epigenomic State Transitions Characterize Tumor Progression in Mouse Lung Adenocarcinoma.
Lindsay M LaFave, Vinay K Kartha, +15 authors, Tyler Jacks.
Cancer Cell, 2020 Jul 25; 38(2). PMID: 32707078    Free PMC article.
TRAIL receptor agonists convert the response of breast cancer cells to ONC201 from anti-proliferative to apoptotic.
Marie D Ralff, Aakash Jhaveri, +6 authors, Wafik S El-Deiry.
Oncotarget, 2020 Nov 05; 11(42). PMID: 33144917    Free PMC article.
A cFos activation map of remote fear memory attenuation.
Bianca A Silva, Allison M Burns, Johannes Gräff.
Psychopharmacology (Berl), 2018 Aug 18; 236(1). PMID: 30116860    Free PMC article.
Establishment and characterisation of testicular cancer patient-derived xenograft models for preclinical evaluation of novel therapeutic strategies.
Gerda de Vries, Ximena Rosas-Plaza, +6 authors, Steven de Jong.
Sci Rep, 2020 Nov 05; 10(1). PMID: 33144587    Free PMC article.
Expression of P16INK4a in Uveal Melanoma: New Perspectives.
Daniela Russo, Rosa Maria Di Crescenzo, +10 authors, Stefania Staibano.
Front Oncol, 2020 Nov 07; 10. PMID: 33154942    Free PMC article.
A versatile toolbox for semi-automatic cell-by-cell object-based colocalization analysis.
Anders Lunde, Joel C Glover.
Sci Rep, 2020 Nov 06; 10(1). PMID: 33149236    Free PMC article.
RUNX1 marks a luminal castration-resistant lineage established at the onset of prostate development.
Renaud Mevel, Ivana Steiner, +9 authors, Georges Lacaud.
Elife, 2020 Oct 08; 9. PMID: 33025905    Free PMC article.
Proline rich 11 (PRR11) overexpression amplifies PI3K signaling and promotes antiestrogen resistance in breast cancer.
Kyung-Min Lee, Angel L Guerrero-Zotano, +13 authors, Carlos L Arteaga.
Nat Commun, 2020 Nov 01; 11(1). PMID: 33127913    Free PMC article.
Type I IFN exacerbates disease in tuberculosis-susceptible mice by inducing neutrophil-mediated lung inflammation and NETosis.
Lúcia Moreira-Teixeira, Philippa J Stimpson, +16 authors, Anne O'Garra.
Nat Commun, 2020 Nov 06; 11(1). PMID: 33149141    Free PMC article.
ImageBox 2 - Efficient and Rapid Access of Image Tiles from Whole-Slide Images Using Serverless HTTP Range Requests.
Erich Bremer, Joel Saltz, Jonas S Almeida.
J Pathol Inform, 2020 Nov 10; 11. PMID: 33163255    Free PMC article.
Microfilaria-dependent thoracic pathology associated with eosinophilic and fibrotic polyps in filaria-infected rodents.
Frédéric Fercoq, Estelle Remion, +6 authors, Coralie Martin.
Parasit Vectors, 2020 Nov 09; 13(1). PMID: 33160409    Free PMC article.
Custodiol-N Is Superior to Custodiol® Solution in Experimental Rat Uterus Preservation.
Viktorija Zitkute, Mindaugas Kvietkauskas, +5 authors, Peter Schemmer.
Int J Mol Sci, 2020 Nov 01; 21(21). PMID: 33126511    Free PMC article.
PyHIST: A Histological Image Segmentation Tool.
Manuel Muñoz-Aguirre, Vasilis F Ntasis, Santiago Rojas, Roderic Guigó.
PLoS Comput Biol, 2020 Oct 20; 16(10). PMID: 33075075    Free PMC article.
Digital Pathology Analysis Quantifies Spatial Heterogeneity of CD3, CD4, CD8, CD20, and FoxP3 Immune Markers in Triple-Negative Breast Cancer.
Haoyang Mi, Chang Gong, +7 authors, Aleksander S Popel.
Front Physiol, 2020 Nov 17; 11. PMID: 33192595    Free PMC article.
Glomerular developmental delay and proteinuria in the preterm neonatal rabbit.
Derek de Winter, Thomas Salaets, +3 authors, Jaan Toelen.
PLoS One, 2020 Nov 10; 15(11). PMID: 33166318    Free PMC article.
Suturable regenerated silk fibroin scaffold reinforced with 3D-printed polycaprolactone mesh: biomechanical performance and subcutaneous implantation.
Ibrahim Fatih Cengiz, Helder Pereira, +3 authors, Joaquim Miguel Oliveira.
J Mater Sci Mater Med, 2019 May 28; 30(6). PMID: 31127379
The Effect of Mouse Strain, Sex, and Carcinogen Dose on Toxicity and the Development of Lung Dysplasia and Squamous Cell Carcinomas in Mice.
Laura Riolobos, Ekram A Gad, +5 authors, Mary L Disis.
Cancer Prev Res (Phila), 2019 May 19; 12(8). PMID: 31101634    Free PMC article.
CCN3 is dynamically regulated by treatment and disease state in multiple sclerosis.
Michelle Naughton, Jill Moffat, +16 authors, Denise C Fitzgerald.
J Neuroinflammation, 2020 Nov 24; 17(1). PMID: 33222687    Free PMC article.
Anti-Aβ antibodies bound to neuritic plaques enhance microglia activity and mitigate tau pathology.
Vanessa Laversenne, Sameer Nazeeruddin, +3 authors, Bernard L Schneider.
Acta Neuropathol Commun, 2020 Nov 24; 8(1). PMID: 33225991    Free PMC article.
Downstream Neighbor of SON (DONSON) Expression Is Enhanced in Phenotypically Aggressive Prostate Cancers.
Niklas Klümper, Marthe von Danwitz, +8 authors, Jörg Ellinger.
Cancers (Basel), 2020 Nov 25; 12(11). PMID: 33228112    Free PMC article.
Cyclin E overexpression confers resistance to trastuzumab through noncanonical phosphorylation of SMAD3 in HER2+ breast cancer.
Joseph T Decker, Pridvi Kandagatla, +4 authors, Jacqueline S Jeruss.
Cancer Biol Ther, 2020 Oct 16; 21(11). PMID: 33054513    Free PMC article.
Early Cytokine Induction Upon Pseudomonas aeruginosa Infection in Murine Precision Cut Lung Slices Depends on Sensing of Bacterial Viability.
Ulrike Kolbe, Buqing Yi, +3 authors, Alexander H Dalpke.
Front Immunol, 2020 Dec 01; 11. PMID: 33250899    Free PMC article.
The GSK3 Signaling Axis Regulates Adaptive Glutamine Metabolism in Lung Squamous Cell Carcinoma.
Milica Momcilovic, Sean T Bailey, +22 authors, David B Shackelford.
Cancer Cell, 2018 May 16; 33(5). PMID: 29763624    Free PMC article.
Highly Cited.
Prognostic and predictive role of CD8 and PD-L1 determination in lung tumor tissue of patients under anti-PD-1 therapy.
Jean-David Fumet, Corentin Richard, +22 authors, François Ghiringhelli.
Br J Cancer, 2018 Oct 16; 119(8). PMID: 30318514    Free PMC article.
Morphological and molecular criteria allow the identification of putative germ stem cells in a lophotrochozoan, the Pacific oyster Crassostrea gigas.
Maëva Cherif-Feildel, Kristell Kellner, +4 authors, Clothilde Heude Berthelin.
Histochem Cell Biol, 2018 Oct 16; 151(5). PMID: 30318560
Precision immunoprofiling by image analysis and artificial intelligence.
Viktor H Koelzer, Korsuk Sirinukunwattana, Jens Rittscher, Kirsten D Mertz.
Virchows Arch, 2018 Nov 25; 474(4). PMID: 30470933    Free PMC article.
Review.
Chronic otitis media is initiated by a bulla cavitation defect in the FBXO11 mouse model.
Jorge Del-Pozo, Neil MacIntyre, +3 authors, Michael Cheeseman.
Dis Model Mech, 2019 Mar 23; 12(3). PMID: 30898767    Free PMC article.
Development and characterisation of acquired radioresistant breast cancer cell lines.
Mark Gray, Arran K Turnbull, +8 authors, David Argyle.
Radiat Oncol, 2019 Apr 17; 14(1). PMID: 30987655    Free PMC article.
Long-term neurological effects of neonatal caffeine treatment in a rabbit model of preterm birth.
Lennart Van der Veeken, Susanne Grönlund, +4 authors, Matteo Bruschettini.
Pediatr Res, 2019 Dec 08; 87(6). PMID: 31812154
Pharmacologic Suppression of B7-H4 Glycosylation Restores Antitumor Immunity in Immune-Cold Breast Cancers.
Xinxin Song, Zhuan Zhou, +7 authors, Yong Wan.
Cancer Discov, 2020 Sep 18; 10(12). PMID: 32938586    Free PMC article.
Whole-slide image analysis outperforms micrograph acquisition for adipocyte size quantification.
Anne S Maguire, Lauren N Woodie, +3 authors, Emily C Graff.
Adipocyte, 2020 Sep 22; 9(1). PMID: 32954932    Free PMC article.
The intestinal quorum sensing 3-oxo-C12:2 Acyl homoserine lactone limits cytokine-induced tight junction disruption.
Doriane Aguanno, Garance Coquant, +7 authors, Sophie Thenet.
Tissue Barriers, 2020 Oct 27; 8(4). PMID: 33100129    Free PMC article.
Coadaptation of the chemosensory system with voluntary exercise behavior in mice.
Quynh Anh Thi Nguyen, David Hillis, +4 authors, Sachiko Haga-Yamanaka.
PLoS One, 2020 Nov 26; 15(11). PMID: 33237909    Free PMC article.
Actionable Cytopathogenic Host Responses of Human Alveolar Type 2 Cells to SARS-CoV-2.
Ryan M Hekman, Adam J Hume, +47 authors, Andrew Emili.
Mol Cell, 2020 Dec 02; 80(6). PMID: 33259812    Free PMC article.
Heat Shock Factor 1-dependent extracellular matrix remodeling mediates the transition from chronic intestinal inflammation to colon cancer.
Oshrat Levi-Galibov, Hagar Lavon, +17 authors, Ruth Scherz-Shouval.
Nat Commun, 2020 Dec 09; 11(1). PMID: 33288768    Free PMC article.
The proteomic landscape of small urinary extracellular vesicles during kidney transplantation.
Fabian Braun, Markus Rinschen, +19 authors, Roman-Ulrich Müller.
J Extracell Vesicles, 2020 Dec 12; 10(1). PMID: 33304478    Free PMC article.
CYP46A1-dependent and independent effects of efavirenz treatment.
Natalia Mast, Nicole El-Darzi, +2 authors, Irina A Pikuleva.
Brain Commun, 2020 Dec 12; 2(2). PMID: 33305262    Free PMC article.
Suppression of glycogen synthesis as a treatment for Lafora disease: Establishing the window of opportunity.
Olga Varea, Jordi Duran, +2 authors, Joan J Guinovart.
Neurobiol Dis, 2020 Nov 11; 147. PMID: 33171226    Free PMC article.
High mutational burden in colorectal carcinomas with monoallelic POLE mutations: absence of allelic loss and gene promoter methylation.
Maja Hühns, Sylvia Nürnberg, +3 authors, Friedrich Prall.
Mod Pathol, 2019 Dec 21; 33(6). PMID: 31857678
Computerized Image Analysis of Tumor Cell Nuclear Morphology Can Improve Patient Selection for Clinical Trials in Localized Clear Cell Renal Cell Carcinoma.
In Hwa Um, Lindesay Scott-Hayward, +9 authors, David J Harrison.
J Pathol Inform, 2020 Dec 22; 11. PMID: 33343995    Free PMC article.
The human tumor microbiome is composed of tumor type-specific intracellular bacteria.
Deborah Nejman, Ilana Livyatan, +58 authors, Ravid Straussman.
Science, 2020 May 30; 368(6494). PMID: 32467386    Free PMC article.
Capillary cell-type specialization in the alveolus.
Astrid Gillich, Fan Zhang, +7 authors, Ross J Metzger.
Nature, 2020 Oct 16; 586(7831). PMID: 33057196    Free PMC article.
Immune Cell Infiltrate and Prognosis in Gastric Cancer.
Niko Kemi, Niko Hiltunen, +9 authors, Joonas H Kauppila.
Cancers (Basel), 2020 Dec 06; 12(12). PMID: 33276550    Free PMC article.
Tumour Stroma Ratio Assessment Using Digital Image Analysis Predicts Survival in Triple Negative and Luminal Breast Cancer.
Ewan Ka Millar, Lois H Browne, +4 authors, Peter H Graham.
Cancers (Basel), 2020 Dec 17; 12(12). PMID: 33322174    Free PMC article.
Role of Hypoxia and the Adenosine System in Immune Evasion and Prognosis of Patients with Brain Metastases of Melanoma: A Multiplex Whole Slide Immunofluorescence Study.
Arnulf Mayer, Maximilian Haist, +5 authors, Heinz Schmidberger.
Cancers (Basel), 2020 Dec 17; 12(12). PMID: 33322215    Free PMC article.
Lung Adenocarcinoma Mouse Models Based on Orthotopic Transplantation of Syngeneic Tumor-Initiating Cells Expressing EpCAM, SCA-1, and Ly6d.
Takashi Semba, Ryo Sato, +6 authors, Yoshimi Arima.
Cancers (Basel), 2020 Dec 23; 12(12). PMID: 33348616    Free PMC article.
Ifit2 deficiency restricts microglial activation and leukocyte migration following murine coronavirus (m-CoV) CNS infection.
Jayasri Das Sarma, Amy Burrows, +5 authors, Ganes C Sen.
PLoS Pathog, 2020 Dec 01; 16(11). PMID: 33253295    Free PMC article.
Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes, in Contrast to Adipose Tissue-Derived Stromal Cells, Efficiently Improve Heart Function in Murine Model of Myocardial Infarction.
Jacek Stępniewski, Mateusz Tomczyk, +13 authors, Józef Dulak.
Biomedicines, 2020 Dec 11; 8(12). PMID: 33297443    Free PMC article.
Stroma Transcriptomic and Proteomic Profile of Prostate Cancer Metastasis Xenograft Models Reveals Prognostic Value of Stroma Signatures.
Sofia Karkampouna, Maria R De Filippo, +7 authors, Marianna Kruithof-de Julio.
Cancers (Basel), 2020 Dec 19; 12(12). PMID: 33334054    Free PMC article.
Derivation of a nuclear heterogeneity image index to grade DCIS.
Mary-Kate Hayward, J Louise Jones, +5 authors, Valerie M Weaver.
Comput Struct Biotechnol J, 2020 Dec 29; 18. PMID: 33363702    Free PMC article.
Macrophage frequency in the bone marrow correlates with morphologic subtype of myeloproliferative neoplasm.
David C A Molitor, Peter Boor, +6 authors, Ines Gütgemann.
Ann Hematol, 2020 Oct 27; 100(1). PMID: 33104881    Free PMC article.
Mutant SF3B1 promotes AKT- and NF-κB-driven mammary tumorigenesis.
Bo Liu, Zhaoqi Liu, +10 authors, Sarat Chandarlapaty.
J Clin Invest, 2020 Oct 09; 131(1). PMID: 33031100    Free PMC article.
Computational Image Analysis of T-Cell Infiltrates in Resectable Gastric Cancer: Association with Survival and Molecular Subtypes.
Benjamin R Challoner, Katharina von Loga, +13 authors, Marco Gerlinger.
J Natl Cancer Inst, 2020 Apr 24; 113(1). PMID: 32324860    Free PMC article.
Engineering transplantable jejunal mucosal grafts using patient-derived organoids from children with intestinal failure.
Laween Meran, Isobel Massie, +22 authors, Vivian S W Li.
Nat Med, 2020 Sep 09; 26(10). PMID: 32895569    Free PMC article.
Heat Shock Protein-90 Inhibition Alters Activation of Pancreatic Stellate Cells and Enhances the Efficacy of PD-1 Blockade in Pancreatic Cancer.
Yuchen Zhang, Michael B Ware, +12 authors, Gregory B Lesinski.
Mol Cancer Ther, 2020 Oct 11; 20(1). PMID: 33037138    Free PMC article.
Association of homozygous variants of STING1 with outcome in human cervical cancer.
Joyce M Lubbers, Bart Koopman, +9 authors, Marco de Bruyn.
Cancer Sci, 2020 Oct 12; 112(1). PMID: 33040406    Free PMC article.
Deletion of Yy1 in mouse lung epithelium unveils molecular mechanisms governing pleuropulmonary blastoma pathogenesis.
Kim Landry-Truchon, Nicolas Houde, +6 authors, Lucie Jeannotte.
Dis Model Mech, 2020 Nov 08; 13(12). PMID: 33158935    Free PMC article.
Expression of human leukocyte antigen class I and β2-microglobulin in colorectal cancer and its prognostic impact.
Hee Young Na, Yujun Park, +6 authors, Hye Seung Lee.
Cancer Sci, 2020 Nov 08; 112(1). PMID: 33159376    Free PMC article.
PD-L1 Multiplex and Quantitative Image Analysis for Molecular Diagnostics.
Fatima Abdullahi Sidi, Victoria Bingham, +4 authors, Manuel Salto-Tellez.
Cancers (Basel), 2020 Dec 31; 13(1). PMID: 33374775    Free PMC article.
Selection of Effective Therapies Using Three-Dimensional in vitro Modeling of Chondrosarcoma.
Ieva Palubeckaitė, Sanne Venneker, +4 authors, Judith V M G Bovée.
Front Mol Biosci, 2021 Jan 12; 7. PMID: 33425984    Free PMC article.
Digitally quantified CD8+ cells: the best candidate marker for an immune cell score in non-small cell lung cancer?
Thomas K Kilvaer, Erna-Elise Paulsen, +4 authors, Tom Donnem.
Carcinogenesis, 2020 Oct 10; 41(12). PMID: 33035322    Free PMC article.
Selective vulnerability of inhibitory networks in multiple sclerosis.
Lida Zoupi, Sam A Booker, +5 authors, Anna C Williams.
Acta Neuropathol, 2021 Jan 16; 141(3). PMID: 33449171    Free PMC article.
Aspirin Rescues Wnt-Driven Stem-like Phenotype in Human Intestinal Organoids and Increases the Wnt Antagonist Dickkopf-1.
Karen Dunbar, Asta Valanciute, +13 authors, Farhat V N Din.
Cell Mol Gastroenterol Hepatol, 2020 Sep 25; 11(2). PMID: 32971322    Free PMC article.
Intratumoural immune signature to identify patients with primary colorectal cancer who do not require follow-up after resection: an observational study.
John N Primrose, Siân A Pugh, +3 authors, David Mant.
Health Technol Assess, 2021 Jan 09; 25(2). PMID: 33416473    Free PMC article.
Primary tumors from mucosal barrier organs drive unique eosinophil infiltration patterns and clinical associations.
Sharon Grisaru-Tal, Michal Itan, +9 authors, Ariel Munitz.
Oncoimmunology, 2021 Jan 19; 10(1). PMID: 33457078    Free PMC article.
Chemotherapy-induced ileal crypt apoptosis and the ileal microbiome shape immunosurveillance and prognosis of proximal colon cancer.
Maria Paula Roberti, Satoru Yonekura, +43 authors, Laurence Zitvogel.
Nat Med, 2020 May 27; 26(6). PMID: 32451498
Phasic Activation of Dorsal Raphe Serotonergic Neurons Increases Pupil Size.
Fanny Cazettes, Davide Reato, +2 authors, Zachary F Mainen.
Curr Biol, 2020 Nov 14; 31(1). PMID: 33186549    Free PMC article.
Ex Vivo Live Full-Thickness Porcine Skin Model as a Versatile In Vitro Testing Method for Skin Barrier Research.
Jee-Hyun Hwang, Haengdueng Jeong, +7 authors, Kyung-Min Lim.
Int J Mol Sci, 2021 Jan 15; 22(2). PMID: 33440780    Free PMC article.
Signaling pathways in human osteoclasts differentiation: ERK1/2 as a key player.
Paula Pennanen, Roope A Kallionpää, +4 authors, Juha Peltonen.
Mol Biol Rep, 2021 Jan 25; 48(2). PMID: 33486672    Free PMC article.
Ral GTPases promote breast cancer metastasis by controlling biogenesis and organ targeting of exosomes.
Shima Ghoroghi, Benjamin Mary, +25 authors, Vincent Hyenne.
Elife, 2021 Jan 07; 10. PMID: 33404012    Free PMC article.
Stem cell-derived CAR T cells traffic to HIV reservoirs in macaques.
Isaac M Barber-Axthelm, Valerie Barber-Axthelm, +7 authors, Christopher W Peterson.
JCI Insight, 2021 Jan 12; 6(1). PMID: 33427210    Free PMC article.
Differential immune microenvironmental features of microsatellite-unstable colorectal cancers according to Fusobacterium nucleatum status.
Ji Ae Lee, Seung-Yeon Yoo, +4 authors, Jung Ho Kim.
Cancer Immunol Immunother, 2020 Jul 06; 70(1). PMID: 32623478
Effects of Acrylic Tunnel Enrichment on Anxiety-Like Behavior, Neurogenesis, and Physiology of C57BL/6J Mice.
Tai L Oatess, Fiona E Harrison, Lauren E Himmel, Carissa P Jones.
J Am Assoc Lab Anim Sci, 2020 Oct 04; 60(1). PMID: 33008490    Free PMC article.
Impact of the repurposed drug thonzonium bromide on host oral-gut microbiomes.
Aurea Simon-Soro, Dongyeop Kim, +6 authors, Hyun Koo.
NPJ Biofilms Microbiomes, 2021 Jan 24; 7(1). PMID: 33483519    Free PMC article.
Modulation of αVβ6 integrin in osteoarthritis-related synovitis and the interaction with VTN(381-397 a.a.) competing for TGF-β1 activation.
Federica Ciregia, Céline Deroyer, +6 authors, Dominique de Seny.
Exp Mol Med, 2021 Feb 03; 53(2). PMID: 33526813    Free PMC article.
Automated digital TIL analysis (ADTA) adds prognostic value to standard assessment of depth and ulceration in primary melanoma.
Michael R Moore, Isabel D Friesner, +26 authors, Yvonne M Saenger.
Sci Rep, 2021 Feb 04; 11(1). PMID: 33531581    Free PMC article.
NOP10 predicts lung cancer prognosis and its associated small nucleolar RNAs drive proliferation and migration.
Chunhong Cui, Yi Liu, +17 authors, Carsten Müller-Tidow.
Oncogene, 2020 Dec 09; 40(5). PMID: 33288886    Free PMC article.
The Use of Quantitative Digital Pathology to Measure Proteoglycan and Glycosaminoglycan Expression and Accumulation in Healthy and Diseased Tissues.
A Sally Davis, Mary Y Chang, +5 authors, Charles W Frevert.
J Histochem Cytochem, 2020 Sep 17; 69(2). PMID: 32936035    Free PMC article.
Review.
Correlation of minimally invasive imaging techniques to assess intestinal mucosal perfusion with established markers of chronic inflammatory enteropathy in dogs.
Mazdak Salavati, Jorge Pérez-Accino, +4 authors, Silke Salavati Schmitz.
J Vet Intern Med, 2020 Dec 15; 35(1). PMID: 33314285    Free PMC article.
Reproducible image handling and analysis.
Kota Miura, Simon F Nørrelykke.
EMBO J, 2021 Jan 23; 40(3). PMID: 33480052    Free PMC article.
In-Depth Immune-Oncology Studies of the Tumor Microenvironment in a Humanized Melanoma Mouse Model.
Jonathan Schupp, Arne Christians, +4 authors, Andrea Tuettenberg.
Int J Mol Sci, 2021 Jan 28; 22(3). PMID: 33498319    Free PMC article.
CXCR4 expression in glioblastoma tissue and the potential for PET imaging and treatment with [68Ga]Ga-Pentixafor /[177Lu]Lu-Pentixather.
Sarah M Jacobs, Pieter Wesseling, +7 authors, Anja G van der Kolk.
Eur J Nucl Med Mol Imaging, 2021 Feb 08;. PMID: 33550492
Multiplexed Immunohistochemical Consecutive Staining on Single Slide (MICSSS): Multiplexed Chromogenic IHC Assay for High-Dimensional Tissue Analysis.
Guray Akturk, Robert Sweeney, +2 authors, Sacha Gnjatic.
Methods Mol Biol, 2019 Sep 11; 2055. PMID: 31502167    Free PMC article.
SuperHistopath: A Deep Learning Pipeline for Mapping Tumor Heterogeneity on Low-Resolution Whole-Slide Digital Histopathology Images.
Konstantinos Zormpas-Petridis, Rosa Noguera, +3 authors, Yinyin Yuan.
Front Oncol, 2021 Feb 09; 10. PMID: 33552964    Free PMC article.
IL6/STAT3 Signaling Hijacks Estrogen Receptor α Enhancers to Drive Breast Cancer Metastasis.
Rasmus Siersbæk, Valentina Scabia, +20 authors, Jason S Carroll.
Cancer Cell, 2020 Jul 18; 38(3). PMID: 32679107    Free PMC article.
Plasma cells are enriched in localized prostate cancer in Black men and are associated with improved outcomes.
Adam B Weiner, Thiago Vidotto, +16 authors, Edward M Schaeffer.
Nat Commun, 2021 Feb 12; 12(1). PMID: 33568675    Free PMC article.
Region-Specific Transcriptional Control of Astrocyte Function Oversees Local Circuit Activities.
Anna Yu-Szu Huang, Junsung Woo, +7 authors, Benjamin Deneen.
Neuron, 2020 Apr 23; 106(6). PMID: 32320644    Free PMC article.
Exploiting Gangliosides for the Therapy of Ewing's Sarcoma and H3K27M-Mutant Diffuse Midline Glioma.
Arthur Wingerter, Khalifa El Malki, +15 authors, Jörg Faber.
Cancers (Basel), 2021 Feb 13; 13(3). PMID: 33572900    Free PMC article.
Research Strategies for Low-Survival Cancers.
Caroline Conway, Denis M Collins, Amanda McCann, Kellie Dean.
Cancers (Basel), 2021 Feb 13; 13(3). PMID: 33573275    Free PMC article.
Next Generation Imaging Techniques to Define Immune Topographies in Solid Tumors.
Violena Pietrobon, Alessandra Cesano, Francesco Marincola, Jakob Nikolas Kather.
Front Immunol, 2021 Feb 16; 11. PMID: 33584676    Free PMC article.
Review.
A toolbox for imaging RIPK1, RIPK3, and MLKL in mouse and human cells.
André L Samson, Cheree Fitzgibbon, +10 authors, James M Murphy.
Cell Death Differ, 2021 Feb 17; 28(7). PMID: 33589776    Free PMC article.
Harnessing non-destructive 3D pathology.
Jonathan T C Liu, Adam K Glaser, +4 authors, Anant Madabhushi.
Nat Biomed Eng, 2021 Feb 17; 5(3). PMID: 33589781    Free PMC article.
Review.
Characterizing the Tumor Immune Microenvironment with Tyramide-Based Multiplex Immunofluorescence.
Hidetoshi Mori, Jennifer Bolen, +6 authors, Michael J Campbell.
J Mammary Gland Biol Neoplasia, 2021 Feb 17; 25(4). PMID: 33590360    Free PMC article.
In-depth characterization of the tumor microenvironment in central nervous system lymphoma reveals implications for immune-checkpoint therapy.
Lukas Marcelis, Asier Antoranz, +11 authors, Thomas Tousseyn.
Cancer Immunol Immunother, 2020 Apr 27; 69(9). PMID: 32335702
Relationship between immune checkpoint proteins, tumour microenvironment characteristics, and prognosis in primary operable colorectal cancer.
Sara Sf Al-Badran, Lauren Grant, +11 authors, Joanne Edwards.
J Pathol Clin Res, 2020 Dec 19; 7(2). PMID: 33338327    Free PMC article.
N-Acetyl-L-cysteine and aminooxyacetic acid differentially modulate trichloroethylene reproductive toxicity via metabolism in Wistar rats.
Anthony L Su, Lawrence H Lash, +2 authors, Rita Loch-Caruso.
Arch Toxicol, 2021 Feb 19; 95(4). PMID: 33599830    Free PMC article.
QuPath: The global impact of an open source digital pathology system.
M P Humphries, P Maxwell, M Salto-Tellez.
Comput Struct Biotechnol J, 2021 Feb 19; 19. PMID: 33598100    Free PMC article.
Review.
Exposure to Maternal Immune Activation Causes Congenital Unfolded Protein Response Defects and Increases the Susceptibility to Postnatal Inflammatory Stimulation in Offspring.
Yo Shimizu, Tsuyoshi Tsukada, +4 authors, Toshihisa Hatta.
J Inflamm Res, 2021 Feb 20; 14. PMID: 33603435    Free PMC article.
Evaluating and comparing immunostaining and computational methods for spatial profiling of drug response in patient-derived explants.
Gareth J Miles, Ian Powley, +5 authors, Catrin Pritchard.
Lab Invest, 2020 Dec 16; 101(3). PMID: 33318618    Free PMC article.
Deep Learning-Based Segmentation and Quantification in Experimental Kidney Histopathology.
Nassim Bouteldja, Barbara M Klinkhammer, +15 authors, Dorit Merhof.
J Am Soc Nephrol, 2020 Nov 07; 32(1). PMID: 33154175    Free PMC article.
Cross-Priming Dendritic Cells Exacerbate Immunopathology After Ischemic Tissue Damage in the Heart.
Elvira Forte, Bryant Perkins, +16 authors, Susanne Sattler.
Circulation, 2020 Dec 11; 143(8). PMID: 33297741    Free PMC article.
Tumor cell plasticity, heterogeneity, and resistance in crucial microenvironmental niches in glioma.
Erik Jung, Matthias Osswald, +11 authors, Frank Winkler.
Nat Commun, 2021 Feb 14; 12(1). PMID: 33579922    Free PMC article.
Systematic evaluation of scoring methods for Ki67 as a surrogate for 21-gene recurrence score.
Soonmyung Paik, Youngmee Kwon, +5 authors, Eun Sook Lee.
NPJ Breast Cancer, 2021 Feb 14; 7(1). PMID: 33579950    Free PMC article.
Developing an enhanced 7-color multiplex IHC protocol to dissect immune infiltration in human cancers.
Zhaoyu Sun, Richard Nyberg, +2 authors, William L Redmond.
PLoS One, 2021 Feb 18; 16(2). PMID: 33596250    Free PMC article.
EXACT: a collaboration toolset for algorithm-aided annotation of images with annotation version control.
Christian Marzahl, Marc Aubreville, +7 authors, Andreas Maier.
Sci Rep, 2021 Feb 25; 11(1). PMID: 33623058    Free PMC article.
The Role of Csmd1 during Mammary Gland Development.
Samuel J Burgess, Hannah Gibbs, +2 authors, Sandra M Bell.
Genes (Basel), 2021 Feb 04; 12(2). PMID: 33530646    Free PMC article.
A Miniaturized Platform for Multiplexed Drug Response Imaging in Live Tumors.
Sharath Bhagavatula, Devon Thompson, +8 authors, Oliver Jonas.
Cancers (Basel), 2021 Feb 11; 13(4). PMID: 33562152    Free PMC article.
Boosted EfficientNet: Detection of Lymph Node Metastases in Breast Cancer Using Convolutional Neural Networks.
Jun Wang, Qianying Liu, +2 authors, Hefeng Zhou.
Cancers (Basel), 2021 Feb 11; 13(4). PMID: 33562232    Free PMC article.
Influence of injection technique, drug formulation and tumor microenvironment on intratumoral immunotherapy delivery and efficacy.
Nina M Muñoz, Malea Williams, +15 authors, Rahul A Sheth.
J Immunother Cancer, 2021 Feb 17; 9(2). PMID: 33589526    Free PMC article.
The immune contexture of primary central nervous system diffuse large B cell lymphoma associates with patient survival and specific cell signaling.
Melissa Alame, Emmanuel Cornillot, +4 authors, Jacques Colinge.
Theranostics, 2021 Mar 06; 11(8). PMID: 33664848    Free PMC article.
Zinc Finger Protein CTCF Regulates Extracellular Matrix (ECM)-Related Gene Expression Associated With the Wnt Signaling Pathway in Gastric Cancer.
Chenbin Liu, Linyi Deng, +9 authors, Yiqun Hu.
Front Oncol, 2021 Mar 06; 10. PMID: 33665169    Free PMC article.
Novel Protein-Based Vaccine against Self-Antigen Reduces the Formation of Sporadic Colon Adenomas in Mice.
Elodie Belnoue, Alyssa A Leystra, +8 authors, Madiha Derouazi.
Cancers (Basel), 2021 Mar 07; 13(4). PMID: 33671373    Free PMC article.
Supercritical Fluid Extract of Putranjiva roxburghii Wall. Seeds Mitigates Fertility Impairment in a Zebrafish Model.
Acharya Balkrishna, Pradeep Nain, +2 authors, Anurag Varshney.
Molecules, 2021 Mar 07; 26(4). PMID: 33672019    Free PMC article.
CD4+ T cells persist for years in the human small intestine and display a TH1 cytokine profile.
Raquel Bartolomé-Casado, Ole J B Landsverk, +9 authors, Frode L Jahnsen.
Mucosal Immunol, 2020 Jun 24; 14(2). PMID: 32572129
Therapeutic enhancement of radiation and immunomodulation by gold nanoparticles in triple negative breast cancer.
Branislava Janic, Stephen L Brown, +7 authors, Ning Wen.
Cancer Biol Ther, 2021 Jan 19; 22(2). PMID: 33459132    Free PMC article.
Islet expression of type I interferon response sensors is associated with immune infiltration and viral infection in type 1 diabetes.
Paola S Apaolaza, Diana Balcacean, +7 authors, nPOD-Virus Group.
Sci Adv, 2021 Feb 26; 7(9). PMID: 33627420    Free PMC article.
3D-microtissue derived secretome as a cell-free approach for enhanced mineralization of scaffolds in the chorioallantoic membrane model.
Lukas Otto, Petra Wolint, +9 authors, Johanna Buschmann.
Sci Rep, 2021 Mar 10; 11(1). PMID: 33686145    Free PMC article.

;. PMID: 32959065
Galectin-3 levels are elevated following nintedanib treatment.
Gali Epstein Shochet, Alon Pomerantz, +8 authors, Tali Zitman-Gal.
Ther Adv Chronic Dis, 2021 Mar 13; 11. PMID: 33708368    Free PMC article.
Noncanonical effector functions of the T-memory-like T-PLL cell are shaped by cooperative TCL1A and TCR signaling.
S Oberbeck, A Schrader, +42 authors, M Herling.
Blood, 2020 Dec 11; 136(24). PMID: 33301031    Free PMC article.
Oxygen Deprivation Modulates EGFR and PD-L1 in Squamous Cell Carcinomas of the Head and Neck.
Sebastian Zahnreich, Senayit Gebrekidan, +3 authors, Arnulf Mayer.
Front Oncol, 2021 Mar 16; 11. PMID: 33718186    Free PMC article.
Apoptotic Blocks in Primary Non-Hodgkin B Cell Lymphomas Identified by BH3 Profiling.
Ryan N Rys, Claudia M Wever, +18 authors, Nathalie A Johnson.
Cancers (Basel), 2021 Mar 07; 13(5). PMID: 33670870    Free PMC article.
CD73 facilitates EMT progression and promotes lung metastases in triple-negative breast cancer.
Nataliia Petruk, Sanni Tuominen, +7 authors, Katri S Selander.
Sci Rep, 2021 Mar 18; 11(1). PMID: 33727591    Free PMC article.
Comparative Analysis of Immunohistochemical Staining Intensity Determined by Light Microscopy, ImageJ and QuPath in Placental Hofbauer Cells.
Katerina Cizkova, Tereza Foltynkova, Mariam Gachechiladze, Zdenek Tauber.
Acta Histochem Cytochem, 2021 Mar 19; 54(1). PMID: 33731967    Free PMC article.
Prognostic role of serum thymidine kinase 1 kinetics during neoadjuvant chemotherapy for early breast cancer.
A Matikas, K Wang, +18 authors, T Foukakis.
ESMO Open, 2021 Mar 14; 6(2). PMID: 33714010    Free PMC article.
Optimization of an automated tumor-infiltrating lymphocyte algorithm for improved prognostication in primary melanoma.
Margaret Chou, Irineu Illa-Bochaca, +8 authors, Hua Zhong.
Mod Pathol, 2020 Oct 03; 34(3). PMID: 33005020    Free PMC article.
A Natural Xenogeneic Endometrial Extracellular Matrix Hydrogel Toward Improving Current Human in vitro Models and Future in vivo Applications.
Sara López-Martínez, Hannes Campo, +6 authors, Irene Cervelló.
Front Bioeng Biotechnol, 2021 Mar 23; 9. PMID: 33748086    Free PMC article.
NOTCH and EZH2 collaborate to repress PTEN expression in breast cancer.
Kyrie Pappas, Tiphaine C Martin, +5 authors, Ramon Parsons.
Commun Biol, 2021 Mar 23; 4(1). PMID: 33750924    Free PMC article.
Modelling human blastocysts by reprogramming fibroblasts into iBlastoids.
Xiaodong Liu, Jia Ping Tan, +14 authors, Jose M Polo.
Nature, 2021 Mar 19; 591(7851). PMID: 33731926
A large-scale internal validation study of unsupervised virtual trichrome staining technologies on nonalcoholic steatohepatitis liver biopsies.
Joshua J Levy, Nasim Azizgolshani, +7 authors, Louis J Vaickus.
Mod Pathol, 2020 Dec 11; 34(4). PMID: 33299110    Free PMC article.
Visualizing Cholesterol in the Brain by On-Tissue Derivatization and Quantitative Mass Spectrometry Imaging.
Roberto Angelini, Eylan Yutuc, +16 authors, William J Griffiths.
Anal Chem, 2021 Mar 10; 93(11). PMID: 33687199    Free PMC article.
Pan-cancer image-based detection of clinically actionable genetic alterations.
Jakob Nikolas Kather, Lara R Heij, +25 authors, Tom Luedde.
Nat Cancer, 2021 Mar 26; 1(8). PMID: 33763651    Free PMC article.
Sodium Fluoride-18 and Radium-223 Dichloride Uptake Colocalize in Osteoblastic Mouse Xenograft Tumors.
Tim E Phelps, Jyoti Roy, +13 authors, Elaine M Jagoda.
Cancer Biother Radiopharm, 2021 Mar 02; 36(2). PMID: 33646017    Free PMC article.
Preoperative immune landscape predisposes adverse outcomes in hepatocellular carcinoma patients with liver transplantation.
Sang-Ho Yoon, Seo-Won Choi, +2 authors, Jin-Wu Nam.
NPJ Precis Oncol, 2021 Mar 28; 5(1). PMID: 33772139    Free PMC article.
Extracellular HMGB1 blockade inhibits tumor growth through profoundly remodeling immune microenvironment and enhances checkpoint inhibitor-based immunotherapy.
Pascale Hubert, Patrick Roncarati, +13 authors, Michael Herfs.
J Immunother Cancer, 2021 Mar 14; 9(3). PMID: 33712445    Free PMC article.
Deep learning-based six-type classifier for lung cancer and mimics from histopathological whole slide images: a retrospective study.
Huan Yang, Lili Chen, +9 authors, Weizhong Li.
BMC Med, 2021 Mar 30; 19(1). PMID: 33775248    Free PMC article.
Meningeal inflammation in multiple sclerosis induces phenotypic changes in cortical microglia that differentially associate with neurodegeneration.
Lynn van Olst, Carla Rodriguez-Mogeda, +16 authors, Maarten E Witte.
Acta Neuropathol, 2021 Mar 30; 141(6). PMID: 33779783    Free PMC article.
Chimeric antigen receptor engineered NK cellular immunotherapy overcomes the selection of T-cell escape variant cancer cells.
Maxwell Y Lee, Yvette Robbins, +12 authors, Clint Allen.
J Immunother Cancer, 2021 Mar 21; 9(3). PMID: 33741731    Free PMC article.
Genome-wide transcriptome study in skin biopsies reveals an association of E2F4 with cadasil and cognitive impairment.
Elena Muiño, Olga Maisterra, +18 authors, Israel Fernández-Cadenas.
Sci Rep, 2021 Mar 27; 11(1). PMID: 33767277    Free PMC article.
Neutrophil-Associated Inflammatory Changes in the Pre-Diabetic Pancreas of Early-Age NOD Mice.
Yesica Garciafigueroa, Brett E Phillips, +2 authors, Nick Giannoukakis.
Front Endocrinol (Lausanne), 2021 Mar 30; 12. PMID: 33776903    Free PMC article.
Tutorial: guidance for quantitative confocal microscopy.
James Jonkman, Claire M Brown, +2 authors, Alison J North.
Nat Protoc, 2020 Apr 03; 15(5). PMID: 32235926
Review.
An amygdala circuit that suppresses social engagement.
Jeong-Tae Kwon, Changhyeon Ryu, +9 authors, Gloria B Choi.
Nature, 2021 Apr 02; 593(7857). PMID: 33790466
Quantifying Breast Cancer-Driven Fiber Alignment and Collagen Deposition in Primary Human Breast Tissue.
Rakesh Gurrala, C Ethan Byrne, +7 authors, Frank H Lau.
Front Bioeng Biotechnol, 2021 Apr 02; 9. PMID: 33791282    Free PMC article.
Deep learning for computer-assisted diagnosis of hereditary diffuse gastric cancer.
Sean A Rasmussen, Thomas Arnason, Weei-Yuarn Huang.
J Pathol Transl Med, 2021 Jan 22; 55(2). PMID: 33472333    Free PMC article.
The Wnt signaling receptor Fzd9 is essential for Myc-driven tumorigenesis in pancreatic islets.
Mariano F Zacarías-Fluck, Toni Jauset, +14 authors, Laura Soucek.
Life Sci Alliance, 2021 Mar 04; 4(5). PMID: 33653688    Free PMC article.
Germinal center reactions in tertiary lymphoid structures associate with neoantigen burden, humoral immunity and long-term survivorship in pancreatic cancer.
Andrew J Gunderson, Venkatesh Rajamanickam, +17 authors, Kristina H Young.
Oncoimmunology, 2021 Apr 03; 10(1). PMID: 33796412    Free PMC article.
Intratumor Heterogeneity in Uveal Melanoma BAP-1 Expression.
Gustav Stålhammar, Hans E Grossniklaus.
Cancers (Basel), 2021 Apr 04; 13(5). PMID: 33800007    Free PMC article.
Proteomic Analyses of Fibroblast- and Serum-Derived Exosomes Identify QSOX1 as a Marker for Non-invasive Detection of Colorectal Cancer.
Nicole Ganig, Franziska Baenke, +12 authors, Christoph Kahlert.
Cancers (Basel), 2021 Apr 04; 13(6). PMID: 33802764    Free PMC article.
CD11c-CD8 Spatial Cross Presentation: A Novel Approach to Link Immune Surveillance and Patient Survival in Soft Tissue Sarcoma.
Yanhong Su, Panagiotis Tsagkozis, +17 authors, Monika Ehnman.
Cancers (Basel), 2021 Apr 04; 13(5). PMID: 33803245    Free PMC article.
Optimal Preclinical Conditions for Using Adult Human Multipotent Neural Cells in the Treatment of Spinal Cord Injury.
Jeong-Seob Won, Je Young Yeon, +7 authors, Kyeung Min Joo.
Int J Mol Sci, 2021 Apr 04; 22(5). PMID: 33806636    Free PMC article.
Anti-Tumor Efficacy of PD-L1 Targeted Alpha-Particle Therapy in a Human Melanoma Xenograft Model.
Marisa Capitao, Justine Perrin, +10 authors, Joëlle Gaschet.
Cancers (Basel), 2021 Apr 04; 13(6). PMID: 33809167    Free PMC article.
Interactive Classification of Whole-Slide Imaging Data for Cancer Researchers.
Sanghoon Lee, Mohamed Amgad, +6 authors, Lee A D Cooper.
Cancer Res, 2020 Dec 24; 81(4). PMID: 33355190    Free PMC article.
Genomic Alterations during the In Situ to Invasive Ductal Breast Carcinoma Transition Shaped by the Immune System.
Anne Trinh, Carlos R Gil Del Alcazar, +11 authors, Kornelia Polyak.
Mol Cancer Res, 2021 Jan 15; 19(4). PMID: 33443130    Free PMC article.
Sphingosine-1-Phosphate Receptor Type 4 (S1P4) Is Differentially Regulated in Peritoneal B1 B Cells upon TLR4 Stimulation and Facilitates the Egress of Peritoneal B1a B Cells and Subsequent Accumulation of Splenic IRA B Cells under Inflammatory Conditions.
Janik Riese, Alina Gromann, +2 authors, Tobias Schulze.
Int J Mol Sci, 2021 Apr 04; 22(7). PMID: 33801658    Free PMC article.
Neoadjuvant Chemotherapy of Triple-Negative Breast Cancer: Evaluation of Early Clinical Response, Pathological Complete Response Rates, and Addition of Platinum Salts Benefit Based on Real-World Evidence.
Milos Holanek, Iveta Selingerova, +10 authors, Alexandr Poprach.
Cancers (Basel), 2021 Apr 04; 13(7). PMID: 33808149    Free PMC article.
Immune Contexture of MMR-Proficient Primary Colorectal Cancer and Matched Liver and Lung Metastases.
Maarit Ahtiainen, Hanna Elomaa, +6 authors, Jukka-Pekka Mecklin.
Cancers (Basel), 2021 Apr 04; 13(7). PMID: 33810354    Free PMC article.
IGF2BP3 Associates with Proliferative Phenotype and Prognostic Features in B-Cell Acute Lymphoblastic Leukemia.
Artturi Mäkinen, Atte Nikkilä, +6 authors, Olli Lohi.
Cancers (Basel), 2021 Apr 04; 13(7). PMID: 33805930    Free PMC article.
Musashi 2 (MSI2) expression as an independent prognostic biomarker in non-small cell lung cancer (NSCLC).
Iuliia Topchu, Nikolai Karnaukhov, +13 authors, Alexander Deneka.
J Thorac Dis, 2021 Apr 13; 13(3). PMID: 33841930    Free PMC article.
Fiji plugins for qualitative image annotations: routine analysis and application to image classification.
Laurent S V Thomas, Franz Schaefer, Jochen Gehrig.
F1000Res, 2021 Apr 14; 9. PMID: 33841801    Free PMC article.
A Genetic Mouse Model Recapitulates Immune Checkpoint Inhibitor-Associated Myocarditis and Supports a Mechanism-Based Therapeutic Intervention.
Spencer C Wei, Wouter C Meijers, +24 authors, James P Allison.
Cancer Discov, 2020 Dec 02; 11(3). PMID: 33257470    Free PMC article.
Brown adipocyte-specific knockout of Bmal1 causes mild but significant thermogenesis impairment in mice.
Nazmul Hasan, Naoto Nagata, +14 authors, Hitoshi Ando.
Mol Metab, 2021 Mar 07; 49. PMID: 33676029    Free PMC article.
Type of chemotherapy has substantial effects on the immune system in ovarian cancer.
Ann Vankerckhoven, Thaïs Baert, +6 authors, An Coosemans.
Transl Oncol, 2021 Mar 27; 14(6). PMID: 33770618    Free PMC article.
Malignant pleural mesothelioma co-opts BCL-XL and autophagy to escape apoptosis.
Duo Xu, Shun-Qing Liang, +10 authors, Ren-Wang Peng.
Cell Death Dis, 2021 Apr 17; 12(4). PMID: 33859162    Free PMC article.
A review and comparison of breast tumor cell nuclei segmentation performances using deep convolutional neural networks.
Andrew Lagree, Majidreza Mohebpour, +8 authors, William T Tran.
Sci Rep, 2021 Apr 15; 11(1). PMID: 33850222    Free PMC article.
PSMA Expression in Glioblastoma as a Basis for Theranostic Approaches: A Retrospective, Correlational Panel Study Including Immunohistochemistry, Clinical Parameters and PET Imaging.
Adrien Holzgreve, Annamaria Biczok, +11 authors, Bogdana Suchorska.
Front Oncol, 2021 Apr 17; 11. PMID: 33859946    Free PMC article.
Systemic sclerosis-associated myositis features minimal inflammation and characteristic capillary pathology.
Elise Siegert, Akinori Uruha, +10 authors, Werner Stenzel.
Acta Neuropathol, 2021 Apr 18; 141(6). PMID: 33864496    Free PMC article.
Disruption of the HER3-PI3K-mTOR oncogenic signaling axis and PD-1 blockade as a multimodal precision immunotherapy in head and neck cancer.
Zhiyong Wang, Yusuke Goto, +12 authors, J Silvio Gutkind.
Nat Commun, 2021 Apr 24; 12(1). PMID: 33888713    Free PMC article.
Oxygen-independent disulfide bond formation in VEGF-A and CA9.
Fiana Levitin, Sandy Che-Eun S Lee, +4 authors, Marianne Koritzinsky.
J Biol Chem, 2021 Mar 07; 296. PMID: 33675747    Free PMC article.
Hypoxia Inducible Factor 1A Supports a Pro-Fibrotic Phenotype Loop in Idiopathic Pulmonary Fibrosis.
Gali Epstein Shochet, Becky Bardenstein-Wald, +6 authors, David Shitrit.
Int J Mol Sci, 2021 Apr 04; 22(7). PMID: 33805152    Free PMC article.
Stabilized epithelial phenotype of cancer cells in primary tumors leads to increased colonization of liver metastasis in pancreatic cancer.
Julienne L Carstens, Sujuan Yang, +7 authors, Raghu Kalluri.
Cell Rep, 2021 Apr 15; 35(2). PMID: 33852841    Free PMC article.
Investigating the relationship between diffusion kurtosis tensor imaging (DKTI) and histology within the normal human brain.
Ahmed Maiter, Frank Riemer, +9 authors, Ferdia A Gallagher.
Sci Rep, 2021 Apr 25; 11(1). PMID: 33893338    Free PMC article.
Rat PRDM9 shapes recombination landscapes, duration of meiosis, gametogenesis, and age of fertility.
Ondrej Mihola, Vladimir Landa, +15 authors, Zdenek Trachtulec.
BMC Biol, 2021 Apr 30; 19(1). PMID: 33910563    Free PMC article.
Estimation of the timing of BAP1 mutation in uveal melanoma progression.
Ogul E Uner, Thonnie Rose O See, +2 authors, Gustav Stålhammar.
Sci Rep, 2021 Apr 28; 11(1). PMID: 33903674    Free PMC article.
Prognostic Modeling of Patients Undergoing Surgery Alone for Esophageal Squamous Cell Carcinoma: A Histopathological and Computed Tomography Based Quantitative Analysis.
Lei-Lei Wu, Jin-Long Wang, +11 authors, Guo-Wei Ma.
Front Oncol, 2021 Apr 30; 11. PMID: 33912439    Free PMC article.
A single intra-articular dose of vitamin D analog calcipotriol alleviates synovitis without adverse effects in rats.
Johanna A Huhtakangas, Jere Huovinen, +5 authors, Petri P Lehenkari.
PLoS One, 2021 Apr 21; 16(4). PMID: 33878143    Free PMC article.
Using the R Package Spatstat to Assess Inhibitory Effects of Microregional Hypoxia on the Infiltration of Cancers of the Head and Neck Region by Cytotoxic T Lymphocytes.
Justus Kaufmann, Christophe A N Biscio, +4 authors, Arnulf Mayer.
Cancers (Basel), 2021 May 01; 13(8). PMID: 33923522    Free PMC article.
Cannabinoid Receptor Type-2 in B Cells Is Associated with Tumor Immunity in Melanoma.
Thomas Gruber, Steve Robatel, +3 authors, Mirjam Schenk.
Cancers (Basel), 2021 May 01; 13(8). PMID: 33923757    Free PMC article.
Evolutionary genetic algorithm identifies IL2RB as a potential predictive biomarker for immune-checkpoint therapy in colorectal cancer.
Matthew Alderdice, Stephanie G Craig, +12 authors, Darragh G McArt.
NAR Genom Bioinform, 2021 May 01; 3(2). PMID: 33928242    Free PMC article.
System for quantitative evaluation of DAB&H-stained breast cancer biopsy digital images (CHISEL).
Lukasz Roszkowiak, Anna Korzynska, +5 authors, Carlos Lopez.
Sci Rep, 2021 May 01; 11(1). PMID: 33927266    Free PMC article.
Tau immunotherapy is associated with glial responses in FTLD-tau.
Boram Kim, Bailey Mikytuck, +9 authors, Edward B Lee.
Acta Neuropathol, 2021 May 06; 142(2). PMID: 33950293    Free PMC article.
PPARɣ drives IL-33-dependent ILC2 pro-tumoral functions.
Giuseppe Ercolano, Alejandra Gomez-Cadena, +14 authors, Camilla Jandus.
Nat Commun, 2021 May 07; 12(1). PMID: 33953160    Free PMC article.
IL-23 skin and joint profiling in psoriatic arthritis: novel perspectives in understanding clinical responses to IL-23 inhibitors.
Alessandra Nerviani, Marie-Astrid Boutet, +7 authors, Costantino Pitzalis.
Ann Rheum Dis, 2020 Nov 28; 80(5). PMID: 33243781    Free PMC article.
Angiogenic hydrogels for dental pulp revascularization.
Zain Siddiqui, Biplab Sarkar, +9 authors, Vivek A Kumar.
Acta Biomater, 2021 Mar 11; 126. PMID: 33689817    Free PMC article.
Growth and differentiation factor 15 and NF-κB expression in benign prostatic biopsies and risk of subsequent prostate cancer detection.
Benjamin A Rybicki, Sudha M Sadasivan, +10 authors, Kenneth A Iczkowski.
Cancer Med, 2021 Mar 31; 10(9). PMID: 33784024    Free PMC article.
A Simple Method for Creating a High-Content Microscope for Imaging Multiplexed Tissue Microarrays.
Shabnam Abtahi, Neal R Gliksman, +7 authors, Jerrold R Turner.
Curr Protoc, 2021 Apr 07; 1(4). PMID: 33822482    Free PMC article.
Quality Considerations When Using Tissue Samples for Biomarker Studies in Cancer Research.
Valerie Speirs.
Biomark Insights, 2021 May 08; 16. PMID: 33958852    Free PMC article.
High expression of microRNA-126 relates to favorable prognosis for colon cancer patients.
Hallgeir Selven, Lill-Tove Rasmussen Busund, +2 authors, Thomas Karsten Kilvær.
Sci Rep, 2021 May 07; 11(1). PMID: 33953222    Free PMC article.
The Mini-Organo: A rapid high-throughput 3D coculture organotypic assay for oncology screening and drug development.
Jessica L Chitty, Joanna N Skhinas, +13 authors, Thomas R Cox.
Cancer Rep (Hoboken), 2020 Jul 17; 3(1). PMID: 32671954    Free PMC article.
Validation of a DKK1 RNAscope chromogenic in situ hybridization assay for gastric and gastroesophageal junction adenocarcinoma tumors.
Charles Caldwell, James B Rottman, +10 authors, Michael H Kagey.
Sci Rep, 2021 May 12; 11(1). PMID: 33972574    Free PMC article.
IL-17a promotes sociability in mouse models of neurodevelopmental disorders.
Michael Douglas Reed, Yeong Shin Yim, +9 authors, Gloria B Choi.
Nature, 2019 Dec 20; 577(7789). PMID: 31853066    Free PMC article.
Intravesical Anti-PD-1 Immune Checkpoint Inhibition Treats Urothelial Bladder Cancer in a Mouse Model.
Austin N Kirschner, Jian Wang, +2 authors, Sam S Chang.
J Urol, 2020 Dec 29; 205(5). PMID: 33356477    Free PMC article.
Imaging mass cytometry reveals generalised deficiency in OXPHOS complexes in Parkinson's disease.
Chun Chen, David McDonald, +10 authors, Amy K Reeve.
NPJ Parkinsons Dis, 2021 May 14; 7(1). PMID: 33980828    Free PMC article.
The role of infiltrating lymphocytes in the neo-adjuvant treatment of women with HER2-positive breast cancer.
A J Eustace, S F Madden, +20 authors, B T Hennessy.
Breast Cancer Res Treat, 2021 May 14; 187(3). PMID: 33983492    Free PMC article.
Evaluation of [18F]F-DPA as a target for TSPO in head and neck cancer under normal conditions and after radiotherapy.
Sanni Tuominen, Thomas Keller, +8 authors, Tove J Grönroos.
Eur J Nucl Med Mol Imaging, 2020 Dec 20; 48(5). PMID: 33340054    Free PMC article.
Enhanced target cell specificity and uptake of lipid nanoparticles using RNA aptamers and peptides.
Roslyn M Ray, Anders Højgaard Hansen, +5 authors, Kira Astakhova.
Beilstein J Org Chem, 2021 May 14; 17. PMID: 33981364    Free PMC article.
Role of neutrophil extracellular traps in radiation resistance of invasive bladder cancer.
Surashri Shinde-Jadhav, Jose Joao Mansure, +8 authors, Wassim Kassouf.
Nat Commun, 2021 May 15; 12(1). PMID: 33986291    Free PMC article.
Longitudinal hippocampal volumetric changes in mice following brain infarction.
Vanessa H Brait, David K Wright, +11 authors, Amy Brodtmann.
Sci Rep, 2021 May 15; 11(1). PMID: 33986303    Free PMC article.
Roles of Motor Cortex Neuron Classes in Reach-Related Modulation for Hemiparkinsonian Rats.
Min Li, Xuenan Wang, +13 authors, Min Wang.
Front Neurosci, 2021 May 15; 15. PMID: 33986639    Free PMC article.
Characterization of the HCN Interaction Partner TRIP8b/PEX5R in the Intracardiac Nervous System of TRIP8b-Deficient and Wild-Type Mice.
Katharina Scherschel, Hanna Bräuninger, +8 authors, Christian Meyer.
Int J Mol Sci, 2021 May 06; 22(9). PMID: 33946275    Free PMC article.
Monocarboxylate Transporters 1 and 4 and MTCO1 in Gastric Cancer.
Maarit Eskuri, Niko Kemi, Joonas H Kauppila.
Cancers (Basel), 2021 May 06; 13(9). PMID: 33946786    Free PMC article.
Novel Combinatorial MicroRNA-Binding Sites in AAV Vectors Synergistically Diminish Antigen Presentation and Transgene Immunity for Efficient and Stable Transduction.
Manish Muhuri, Wei Zhan, +13 authors, Guangping Gao.
Front Immunol, 2021 May 18; 12. PMID: 33995418    Free PMC article.
Transcriptomic and Immunophenotypic Characterization of Tumor Immune Microenvironment in Squamous Cell Carcinoma of the Oral Tongue.
Kyriakos Chatzopoulos, Sotiris Sotiriou, +9 authors, Joaquin J Garcia.
Head Neck Pathol, 2020 Oct 04; 15(2). PMID: 33010009    Free PMC article.
Sex-specific prognostic effect of CD66b-positive tumor-infiltrating neutrophils (TANs) in gastric and esophageal adenocarcinoma.
Alexander Quaas, Aylin Pamuk, +13 authors, Hakan Alakus.
Gastric Cancer, 2021 May 20; 24(6). PMID: 34009535    Free PMC article.
Identification of the skeletal progenitor cells forming osteophytes in osteoarthritis.
Anke J Roelofs, Karolina Kania, +17 authors, Cosimo De Bari.
Ann Rheum Dis, 2020 Sep 24; 79(12). PMID: 32963046    Free PMC article.
A thalamo-amygdalar circuit underlying the extinction of remote fear memories.
Bianca A Silva, Simone Astori, +6 authors, Johannes Gräff.
Nat Neurosci, 2021 May 22; 24(7). PMID: 34017129
BNIP3 promotes HIF-1α-driven melanoma growth by curbing intracellular iron homeostasis.
Mónica Vara-Pérez, Matteo Rossi, +19 authors, Patrizia Agostinis.
EMBO J, 2021 May 02; 40(10). PMID: 33932034    Free PMC article.
Artificial Intelligence in Pathology: From Prototype to Product.
André Homeyer, Johannes Lotz, +5 authors, Peter Hufnagl.
J Pathol Inform, 2021 May 21; 12. PMID: 34012717    Free PMC article.
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Conventional and semi-automatic histopathological analysis of tumor cell content for multigene sequencing of lung adenocarcinoma.
Daniel Kazdal, Eugen Rempel, +29 authors, Mark Kriegsmann.
Transl Lung Cancer Res, 2021 May 21; 10(4). PMID: 34012783    Free PMC article.
Deep Learning Based on Standard H&E Images of Primary Melanoma Tumors Identifies Patients at Risk for Visceral Recurrence and Death.
Prathamesh M Kulkarni, Eric J Robinson, +19 authors, Yvonne M Saenger.
Clin Cancer Res, 2019 Oct 23; 26(5). PMID: 31636101    Free PMC article.
Dissecting intratumour heterogeneity of nodal B-cell lymphomas at the transcriptional, genetic and drug-response levels.
Tobias Roider, Julian Seufert, +23 authors, Sascha Dietrich.
Nat Cell Biol, 2020 Jun 17; 22(7). PMID: 32541878
Evaluation Challenges in the Validation of B7-H3 as Oral Tongue Cancer Prognosticator.
Meri Sieviläinen, Anna Maria Wirsing, +10 authors, Ahmed Al-Samadi.
Head Neck Pathol, 2020 Sep 23; 15(2). PMID: 32959211    Free PMC article.
Distribution and Severity of Placental Lesions Caused by the Chlamydia abortus 1B Vaccine Strain in Vaccinated Ewes.
Sergio Gastón Caspe, Javier Palarea-Albaladejo, +6 authors, David Longbottom.
Pathogens, 2021 May 06; 10(5). PMID: 33946380    Free PMC article.
Automated gleason grading on prostate biopsy slides by statistical representations of homology profile.
Chaoyang Yan, Kazuaki Nakane, +6 authors, Jun Xu.
Comput Methods Programs Biomed, 2020 May 30; 194. PMID: 32470903    Free PMC article.
A molecular single-cell lung atlas of lethal COVID-19.
Johannes C Melms, Jana Biermann, +41 authors, Benjamin Izar.
Nature, 2021 Apr 30; 595(7865). PMID: 33915568
Fibroblast dedifferentiation as a determinant of successful regeneration.
Tzi-Yang Lin, Tobias Gerber, +6 authors, Elly M Tanaka.
Dev Cell, 2021 May 19; 56(10). PMID: 34004152    Free PMC article.
BMAL1-Driven Tissue Clocks Respond Independently to Light to Maintain Homeostasis.
Patrick-Simon Welz, Valentina M Zinna, +13 authors, Salvador Aznar Benitah.
Cell, 2019 Jun 01; 177(6). PMID: 31150620    Free PMC article.
Specific populations of basal ganglia output neurons target distinct brain stem areas while collateralizing throughout the diencephalon.
Lauren E McElvain, Yuncong Chen, +5 authors, David Kleinfeld.
Neuron, 2021 Apr 07; 109(10). PMID: 33823137    Free PMC article.
Apc-mutant cells act as supercompetitors in intestinal tumour initiation.
Sanne M van Neerven, Nina E de Groot, +22 authors, Louis Vermeulen.
Nature, 2021 Jun 04; 594(7863). PMID: 34079128
Parental genome unification is highly error-prone in mammalian embryos.
Tommaso Cavazza, Yuko Takeda, +12 authors, Melina Schuh.
Cell, 2021 May 09; 184(11). PMID: 33964210    Free PMC article.
A non-genetic, cell cycle-dependent mechanism of platinum resistance in lung adenocarcinoma.
Alvaro Gonzalez Rajal, Kamila A Marzec, +12 authors, Andrew Burgess.
Elife, 2021 May 14; 10. PMID: 33983115    Free PMC article.
Integration of Spatial PD-L1 Expression with the Tumor Immune Microenvironment Outperforms Standard PD-L1 Scoring in Outcome Prediction of Urothelial Cancer Patients.
Veronika Weyerer, Pamela L Strissel, +13 authors, Markus Eckstein.
Cancers (Basel), 2021 Jun 03; 13(10). PMID: 34066058    Free PMC article.
Deep Learning for the Classification of Non-Hodgkin Lymphoma on Histopathological Images.
Georg Steinbuss, Mark Kriegsmann, +5 authors, Katharina Kriegsmann.
Cancers (Basel), 2021 Jun 03; 13(10). PMID: 34067726    Free PMC article.
Dystrophin Deficiency Causes Progressive Depletion of Cardiovascular Progenitor Cells in the Heart.
Sarka Jelinkova, Yvonne Sleiman, +15 authors, Albano C Meli.
Int J Mol Sci, 2021 Jun 03; 22(9). PMID: 34068508    Free PMC article.
Clinical and Biological Subtypes of B-cell Lymphoma Revealed by Microenvironmental Signatures.
Nikita Kotlov, Alexander Bagaev, +18 authors, Leandro Cerchietti.
Cancer Discov, 2021 Feb 06; 11(6). PMID: 33541860    Free PMC article.
Ileal immune tonus is a prognosis marker of proximal colon cancer in mice and patients.
Marion Picard, Satoru Yonekura, +25 authors, Maria Paula Roberti.
Cell Death Differ, 2020 Dec 03; 28(5). PMID: 33262469    Free PMC article.
Ex Vivo MR Histology and Cytometric Feature Mapping Connect Three-dimensional in Vivo MR Images to Two-dimensional Histopathologic Images of Murine Sarcomas.
Stephanie J Blocker, James Cook, +9 authors, G Allan Johnson.
Radiol Imaging Cancer, 2021 May 22; 3(3). PMID: 34018846    Free PMC article.
PRoBE the cloud toolkit: finding the best biomarkers of drug response within a breast cancer clinical trial.
Nicholas O'Grady, David L Gibbs, +10 authors, Amrita Basu.
JAMIA Open, 2021 Jun 08; 4(2). PMID: 34095775    Free PMC article.
Blockade of the co-inhibitory molecule PD-1 unleashes ILC2-dependent antitumor immunity in melanoma.
Nicolas Jacquelot, Cyril Seillet, +34 authors, Gabrielle T Belz.
Nat Immunol, 2021 Jun 09; 22(7). PMID: 34099918    Free PMC article.
A versatile reverse genetics platform for SARS-CoV-2 and other positive-strand RNA viruses.
Alberto A Amarilla, Julian D J Sng, +28 authors, Alexander A Khromykh.
Nat Commun, 2021 Jun 10; 12(1). PMID: 34103499    Free PMC article.
Stromal hyaluronan accumulation is associated with low immune response and poor prognosis in pancreatic cancer.
Kyösti Tahkola, Maarit Ahtiainen, +6 authors, Jan Böhm.
Sci Rep, 2021 Jun 11; 11(1). PMID: 34108626    Free PMC article.
Metformin inhibition of mitochondrial ATP and DNA synthesis abrogates NLRP3 inflammasome activation and pulmonary inflammation.
Hongxu Xian, Yuan Liu, +17 authors, Elsa Sanchez-Lopez.
Immunity, 2021 Jun 12; 54(7). PMID: 34115964    Free PMC article.
Connective Tissue Growth Factor Is Overexpressed in Explant Lung Tissue and Broncho-Alveolar Lavage in Transplant-Related Pulmonary Fibrosis.
Arno Vanstapel, Roel Goldschmeding, +15 authors, Robin Vos.
Front Immunol, 2021 Jun 15; 12. PMID: 34122421    Free PMC article.
Impact of PD-L1 and PD-1 Expression on the Prognostic Significance of CD8+ Tumor-Infiltrating Lymphocytes in Non-Small Cell Lung Cancer.
Enrico Munari, Marcella Marconi, +16 authors, Giuseppe Bogina.
Front Immunol, 2021 Jun 15; 12. PMID: 34122444    Free PMC article.
A single-cell RNA expression atlas of normal, preneoplastic and tumorigenic states in the human breast.
Bhupinder Pal, Yunshun Chen, +14 authors, Jane E Visvader.
EMBO J, 2021 May 06; 40(11). PMID: 33950524    Free PMC article.
Tissue-resident macrophages provide a pro-tumorigenic niche to early NSCLC cells.
María Casanova-Acebes, Erica Dalla, +24 authors, Miriam Merad.
Nature, 2021 Jun 18; 595(7868). PMID: 34135508
Molecular docking-aided identification of small molecule inhibitors targeting β-catenin-TCF4 interaction.
Joo-Leng Low, Weina Du, +9 authors, Ramanuj DasGupta.
iScience, 2021 Jun 19; 24(6). PMID: 34142050    Free PMC article.
Characterizing the Invasive Tumor Front of Aggressive Uterine Adenocarcinoma and Leiomyosarcoma.
Sabina Sanegre, Núria Eritja, +13 authors, Rosa Noguera.
Front Cell Dev Biol, 2021 Jun 22; 9. PMID: 34150764    Free PMC article.
The HIF complex recruits the histone methyltransferase SET1B to activate specific hypoxia-inducible genes.
Brian M Ortmann, Natalie Burrows, +12 authors, James A Nathan.
Nat Genet, 2021 Jun 23; 53(7). PMID: 34155378    Free PMC article.
Classifying Retinal Degeneration in Histological Sections Using Deep Learning.
Daniel Al Mouiee, Erik Meijering, +8 authors, Mohit N Shivdasani.
Transl Vis Sci Technol, 2021 Jun 11; 10(7). PMID: 34110385    Free PMC article.
Co-evolution of matrisome and adaptive adhesion dynamics drives ovarian cancer chemoresistance.
Elina A Pietilä, Jordi Gonzalez-Molina, +17 authors, Kaisa Lehti.
Nat Commun, 2021 Jun 25; 12(1). PMID: 34162871    Free PMC article.
A new tool for technical standardization of the Ki67 immunohistochemical assay.
Thazin Nwe Aung, Balazs Acs, +10 authors, David L Rimm.
Mod Pathol, 2021 Feb 05; 34(7). PMID: 33536573    Free PMC article.
Highlights from the 2016-2020 NEUBIAS training schools for Bioimage Analysts: a success story and key asset for analysts and life scientists.
Gabriel G Martins, Fabrice P Cordelières, +9 authors, Kota Miura.
F1000Res, 2021 Jun 25; 10. PMID: 34164115    Free PMC article.
Follicular helper-T cells restore CD8+-dependent antitumor immunity and anti-PD-L1/PD-1 efficacy.
Julie Niogret, Hélène Berger, +15 authors, Fanny Chalmin.
J Immunother Cancer, 2021 Jun 10; 9(6). PMID: 34103351    Free PMC article.
Central nervous system-targeted adeno-associated virus gene therapy in methylmalonic acidemia.
Francis J May, PamelaSara E Head, +2 authors, Charles P Venditti.
Mol Ther Methods Clin Dev, 2021 Jun 26; 21. PMID: 34169115    Free PMC article.
The clinical and molecular significance associated with STING signaling in breast cancer.
Eileen E Parkes, Matthew P Humphries, +13 authors, Niamh E Buckley.
NPJ Breast Cancer, 2021 Jun 27; 7(1). PMID: 34172750    Free PMC article.
A preclinical pipeline to evaluate migrastatics as therapeutic agents in metastatic melanoma.
Oscar Maiques, Bruce Fanshawe, +8 authors, Gilbert O Fruhwirth.
Br J Cancer, 2021 Jun 27; 125(5). PMID: 34172930    Free PMC article.
Whole-Slide Image Analysis of Human Pancreas Samples to Elucidate the Immunopathogenesis of Type 1 Diabetes Using the QuPath Software.
Paola S Apaolaza, Peristera-Ioanna Petropoulou, Teresa Rodriguez-Calvo.
Front Mol Biosci, 2021 Jun 29; 8. PMID: 34179094    Free PMC article.
Developmental partitioning of SYK and ZAP70 prevents autoimmunity and cancer.
Teresa Sadras, Mickaël Martin, +27 authors, Markus Müschen.
Mol Cell, 2021 Apr 21; 81(10). PMID: 33878293    Free PMC article.
Promotion of cholangiocarcinoma growth by diverse cancer-associated fibroblast subpopulations.
Silvia Affo, Ajay Nair, +34 authors, Robert F Schwabe.
Cancer Cell, 2021 May 01; 39(6). PMID: 33930309    Free PMC article.
A series of COVID-19 autopsies with clinical and pathologic comparisons to both seasonal and pandemic influenza.
Phillip McMullen, Peter Pytel, +15 authors, Jeffrey Mueller.
J Pathol Clin Res, 2021 May 08; 7(5). PMID: 33960723    Free PMC article.
Epithelial cell transforming 2 is regulated by Yes-associated protein 1 and mediates pancreatic cancer progression and metastasis.
Ce Li, Zhenzi Peng, +8 authors, Qiang Wang.
Am J Physiol Gastrointest Liver Physiol, 2021 Jan 28; 320(3). PMID: 33501895    Free PMC article.
Immune Remodeling of the Extracellular Matrix Drives Loss of Cancer Stem Cells and Tumor Rejection.
Ana Pires, Alexander Greenshields-Watson, +12 authors, Awen Gallimore.
Cancer Immunol Res, 2020 Oct 08; 8(12). PMID: 33023965    Free PMC article.
Activatable Zymography Probes Enable In Situ Localization of Protease Dysregulation in Cancer.
Ava P Soleimany, Jesse D Kirkpatrick, +4 authors, Sangeeta N Bhatia.
Cancer Res, 2020 Oct 28; 81(1). PMID: 33106334    Free PMC article.
Preclinical study of a novel therapeutic vaccine for recurrent respiratory papillomatosis.
Maxwell Y Lee, Simon Metenou, +5 authors, Clint T Allen.
NPJ Vaccines, 2021 Jun 20; 6(1). PMID: 34145272    Free PMC article.
A platform for locoregional T-cell immunotherapy to control HNSCC recurrence following tumor resection.
Shay Sharon, Jason R Baird, +8 authors, Michael J Gough.
Oncotarget, 2021 Jul 02; 12(13). PMID: 34194619    Free PMC article.
Basophils balance healing after myocardial infarction via IL-4/IL-13.
Florian Sicklinger, Ingmar Sören Meyer, +16 authors, Florian Leuschner.
J Clin Invest, 2021 Jul 02; 131(13). PMID: 34196299    Free PMC article.
NF-κB Blockade with Oral Administration of Dimethylaminoparthenolide (DMAPT), Delays Prostate Cancer Resistance to Androgen Receptor (AR) Inhibition and Inhibits AR Variants.
Katherine L Morel, Anis A Hamid, +3 authors, Christopher J Sweeney.
Mol Cancer Res, 2021 Apr 18; 19(7). PMID: 33863813    Free PMC article.
Dietary Melatonin and Glycine Decrease Tumor Growth through Antiangiogenic Activity in Experimental Colorectal Liver Metastasis.
Mindaugas Kvietkauskas, Viktorija Zitkute, +3 authors, Peter Schemmer.
Nutrients, 2021 Jul 03; 13(6). PMID: 34199311    Free PMC article.
Targeting the NAD Salvage Synthesis Pathway as a Novel Therapeutic Strategy for Osteosarcomas with Low NAPRT Expression.
Natasja Franceschini, Jan Oosting, +7 authors, Anne-Marie Cleton-Jansen.
Int J Mol Sci, 2021 Jul 03; 22(12). PMID: 34200964    Free PMC article.
A Novel Model for Nephrotic Syndrome Reveals Associated Dysbiosis of the Gut Microbiome and Extramedullary Hematopoiesis.
Jasmin I Maier, Manuel Rogg, +4 authors, Christoph Schell.
Cells, 2021 Jul 03; 10(6). PMID: 34203913    Free PMC article.
Explant Modeling of the Immune Environment of Head and Neck Cancer.
Shay Sharon, Thomas Duhen, +9 authors, Michael Gough.
Front Oncol, 2021 Jul 06; 11. PMID: 34221953    Free PMC article.
A Novel Nomogram Based on Machine Learning-Pathomics Signature and Neutrophil to Lymphocyte Ratio for Survival Prediction of Bladder Cancer Patients.
Siteng Chen, Liren Jiang, +6 authors, Junhua Zheng.
Front Oncol, 2021 Jul 06; 11. PMID: 34222026    Free PMC article.
Agonistic CD40 therapy induces tertiary lymphoid structures but impairs responses to checkpoint blockade in glioma.
Luuk van Hooren, Alessandra Vaccaro, +16 authors, Anna Dimberg.
Nat Commun, 2021 Jul 07; 12(1). PMID: 34226552    Free PMC article.
Dual therapeutic targeting of intra-articular inflammation and intracellular bacteria enhances chondroprotection in septic arthritis.
Hyuk-Kwon Kwon, Inkyu Lee, +9 authors, Francis Y Lee.
Sci Adv, 2021 Jun 27; 7(26). PMID: 34172438    Free PMC article.
Effect of pore size and spacing on neovascularization of a biodegradble shape memory polymer perivascular wrap.
Timothy C Boire, Lauren E Himmel, +5 authors, Craig L Duvall.
J Biomed Mater Res A, 2020 Jun 04; 109(3). PMID: 32490564    Free PMC article.
Deep Learning Enables Individual Xenograft Cell Classification in Histological Images by Analysis of Contextual Features.
Quentin Juppet, Fabio De Martino, +5 authors, Daniel Sage.
J Mammary Gland Biol Neoplasia, 2021 May 18; 26(2). PMID: 33999331    Free PMC article.
Single cell derived mRNA signals across human kidney tumors.
Matthew D Young, Thomas J Mitchell, +42 authors, Sam Behjati.
Nat Commun, 2021 Jun 25; 12(1). PMID: 34162837    Free PMC article.
Clinicopathological Significance of Syndecan-1 in Cholangiocarcinoma: A Study Based on Immunohistochemistry and Public Sequencing Data.
Tiemo S Gerber, Fabian Bartsch, +5 authors, Beate K Straub.
J Clin Med, 2021 Jul 03; 10(13). PMID: 34206469    Free PMC article.
Anti-tumor efficacy of a combination therapy with PD-L1 targeted alpha therapy and adoptive cell transfer of PD-1 deficient melanoma-specific human T-lymphocytes.
L Marotte, M Capitao, +11 authors, N Labarriere.
Oncoimmunology, 2021 Jul 10; 10(1). PMID: 34239774    Free PMC article.
Contraceptive progestins with androgenic properties stimulate breast epithelial cell proliferation.
Marie Shamseddin, Fabio De Martino, +12 authors, Cathrin Brisken.
EMBO Mol Med, 2021 May 28; 13(7). PMID: 34042278    Free PMC article.
The miR-200-Zeb1 axis regulates key aspects of β-cell function and survival in vivo.
Alexandra C Title, Pamuditha N Silva, +2 authors, Markus Stoffel.
Mol Metab, 2021 Jun 12; 53. PMID: 34116231    Free PMC article.
A Standardized Analysis of Tertiary Lymphoid Structures in Human Melanoma: Disease Progression- and Tumor Site-Associated Changes With Germinal Center Alteration.
Franziska Werner, Christine Wagner, +5 authors, Stephan N Wagner.
Front Immunol, 2021 Jul 13; 12. PMID: 34248957    Free PMC article.
Circulating and Synovial Pentraxin-3 (PTX3) Expression Levels Correlate With Rheumatoid Arthritis Severity and Tissue Infiltration Independently of Conventional Treatments Response.
Marie-Astrid Boutet, Alessandra Nerviani, +10 authors, Costantino Pitzalis.
Front Immunol, 2021 Jul 13; 12. PMID: 34248970    Free PMC article.
Developing open-source software for bioimage analysis: opportunities and challenges.
Florian Levet, Anne E Carpenter, +3 authors, Robert Haase.
F1000Res, 2021 Jul 13; 10. PMID: 34249339    Free PMC article.
Regular Dietary Intake of Palmitate Causes Vascular and Valvular Calcification in a Rabbit Model.
Nathalie Donis, Zheshen Jiang, +7 authors, Cécile Oury.
Front Cardiovasc Med, 2021 Jul 13; 8. PMID: 34250045    Free PMC article.
Complete response to neoadjuvant chemoradiotherapy in rectal cancer is associated with RAS/AKT mutations and high tumour mutational burden.
Joanne D Stockton, Louise Tee, +8 authors, Andrew D Beggs.
Radiat Oncol, 2021 Jul 15; 16(1). PMID: 34256782    Free PMC article.
Automated PD-L1 Scoring for Non-Small Cell Lung Carcinoma Using Open-Source Software.
Julia R Naso, Tetiana Povshedna, +4 authors, Chen Zhou.
Pathol Oncol Res, 2021 Jul 15; 27. PMID: 34257575    Free PMC article.
Mebendazole disrupts stromal desmoplasia and tumorigenesis in two models of pancreatic cancer.
Tara Williamson, Michelle Carvalho de Abreu, +6 authors, Gregory J Riggins.
Oncotarget, 2021 Jul 16; 12(14). PMID: 34262644    Free PMC article.
Bevacizumab improves tumor infiltration of mature dendritic cells and effector T-cells in triple-negative breast cancer patients.
Yves Boucher, Ashwin S Kumar, +8 authors, Rakesh K Jain.
NPJ Precis Oncol, 2021 Jul 01; 5(1). PMID: 34188163    Free PMC article.
Dicom_wsi: A Python Implementation for Converting Whole-Slide Images to Digital Imaging and Communications in Medicine Compliant Files.
Qiangqiang Gu, Naresh Prodduturi, +2 authors, Steven N Hart.
J Pathol Inform, 2021 Jul 17; 12. PMID: 34267986    Free PMC article.
Mutant IDH Sensitizes Gliomas to Endoplasmic Reticulum Stress and Triggers Apoptosis via miR-183-Mediated Inhibition of Semaphorin 3E.
Ying Zhang, Stefan Pusch, +13 authors, Sebastian Brandner.
Cancer Res, 2019 Aug 09; 79(19). PMID: 31391185    Free PMC article.
First-in-Human Study of AT13148, a Dual ROCK-AKT Inhibitor in Patients with Solid Tumors.
Robert McLeod, Rajiv Kumar, +17 authors, Udai Banerji.
Clin Cancer Res, 2020 Jul 04; 26(18). PMID: 32616501    Free PMC article.
CD3+, CD8+, CD4+ and FOXP3+ T Cells in the Immune Microenvironment of Small Bowel Neuroendocrine Tumors.
Niko Hiltunen, Juha P Väyrynen, Jan Böhm, Olli Helminen.
Diseases, 2021 Jul 03; 9(2). PMID: 34208144    Free PMC article.
Statistical and machine learning methods for spatially resolved transcriptomics with histology.
Jian Hu, Amelia Schroeder, +3 authors, Mingyao Li.
Comput Struct Biotechnol J, 2021 Jul 22; 19. PMID: 34285782    Free PMC article.
Review.
IL-1B drives opposing responses in primary tumours and bone metastases; harnessing combination therapies to improve outcome in breast cancer.
Claudia Tulotta, Diane V Lefley, +13 authors, Penelope D Ottewell.
NPJ Breast Cancer, 2021 Jul 23; 7(1). PMID: 34290237    Free PMC article.
Parallel in vivo experimental evolution reveals that increased stress resistance was key for the emergence of persistent tuberculosis bacilli.
Aideen C Allen, Wladimir Malaga, +12 authors, Christophe Guilhot.
Nat Microbiol, 2021 Jul 24; 6(8). PMID: 34294904
Hippocampal subfield pathologic Burden in Lewy body diseases versus Alzheimer's disease.
David G Coughlin, Murray Grossman, John Q Trojanowski, David J Irwin.
Neuropathol Appl Neurobiol, 2021 Jan 26; 47(5). PMID: 33492664    Free PMC article.
Multifaceted modes of action of the anticancer probiotic Enterococcus hirae.
Anne-Gaëlle Goubet, Richard Wheeler, +27 authors, Romain Daillère.
Cell Death Differ, 2021 May 13; 28(7). PMID: 33976389    Free PMC article.
The Transcriptome of Paired Major and Minor Salivary Gland Tissue in Patients With Primary Sjögren's Syndrome.
Gwenny M Verstappen, Lu Gao, +12 authors, Frans G M Kroese.
Front Immunol, 2021 Jul 24; 12. PMID: 34295332    Free PMC article.
Viability of acellular biologic graft for nipple-areolar complex reconstruction in a non-human primate model.
Vincent C Caronna, Allison F Rosenberg, +6 authors, Nicholas C Pashos.
Sci Rep, 2021 Jul 25; 11(1). PMID: 34301975    Free PMC article.
Higher Number of EBI3 Cells in Mucosal Chronic Hyperplastic Candidiasis May Serve to Regulate IL-17-Producing Cells.
Ailish Williams, Helen Rogers, +4 authors, Adam Jones.
J Fungi (Basel), 2021 Jul 03; 7(7). PMID: 34209407    Free PMC article.
Electrophysiologic and Morphologic Strain Differences in a Low-Dose NaIO3-Induced Retinal Pigment Epithelium Damage Model.
Nan Zhang, Xian Zhang, +9 authors, John M Nickerson.
Transl Vis Sci Technol, 2021 Jul 13; 10(8). PMID: 34251426    Free PMC article.
ACE2-lentiviral transduction enables mouse SARS-CoV-2 infection and mapping of receptor interactions.
Daniel J Rawle, Thuy T Le, +8 authors, Andreas Suhrbier.
PLoS Pathog, 2021 Jul 03; 17(7). PMID: 34214142    Free PMC article.
Genotoxic Treatment Enhances Immune Response in a Genetic Model of Lung Cancer.
Pasquale Saggese, Cesar A Martinez, +8 authors, Claudio Scafoglio.
Cancers (Basel), 2021 Jul 25; 13(14). PMID: 34298808    Free PMC article.
N-Acetylcysteine Added to Local Anesthesia Reduces Scar Area and Width in Early Wound Healing-An Animal Model Study.
Wiktor Paskal, Adriana M Paskal, +8 authors, Paweł Włodarski.
Int J Mol Sci, 2021 Jul 25; 22(14). PMID: 34299175    Free PMC article.
The value of GATA6 immunohistochemistry and computer-assisted diagnosis to predict clinical outcome in advanced pancreatic cancer.
Kai Duan, Gun-Ho Jang, +6 authors, Sandra Fischer.
Sci Rep, 2021 Jul 24; 11(1). PMID: 34294813    Free PMC article.
Multiplex gene analysis reveals T-cell and antibody-mediated rejection-specific upregulation of complement in renal transplants.
Eva Vonbrunn, Tajana Ries, +4 authors, Christoph Daniel.
Sci Rep, 2021 Jul 31; 11(1). PMID: 34326417    Free PMC article.
Single-Cell Transcriptional Survey of Ileal-Anal Pouch Immune Cells From Ulcerative Colitis Patients.
Joseph C Devlin, Jordan Axelrad, +7 authors, P'ng Loke.
Gastroenterology, 2020 Dec 29; 160(5). PMID: 33359089    Free PMC article.
Endometrial laminin subunit beta-3 expression associates with reproductive outcome in patients with repeated implantation failure.
Tiantian Li, Ellen M Greenblatt, +2 authors, Crystal Chan.
J Assist Reprod Genet, 2021 Mar 15; 38(7). PMID: 33715134    Free PMC article.
Myeloid Cell-associated Resistance to PD-1/PD-L1 Blockade in Urothelial Cancer Revealed Through Bulk and Single-cell RNA Sequencing.
Li Wang, John P Sfakianos, +18 authors, Matthew D Galsky.
Clin Cancer Res, 2021 Apr 11; 27(15). PMID: 33837006    Free PMC article.
Nuclear FGFR1 Regulates Gene Transcription and Promotes Antiestrogen Resistance in ER+ Breast Cancer.
Alberto Servetto, Rahul Kollipara, +13 authors, Carlos L Arteaga.
Clin Cancer Res, 2021 May 21; 27(15). PMID: 34011560    Free PMC article.
Effective Detection and Monitoring of Glioma Using [18F]FPIA PET Imaging.
Vessela Vassileva, Marta Braga, +9 authors, Eric O Aboagye.
Biomedicines, 2021 Aug 07; 9(7). PMID: 34356874    Free PMC article.
Neuropilin-1 Expression Associates with Poor Prognosis in HNSCC and Elicits EGFR Activation upon CDDP-Induced Cytotoxic Stress.
Virginia Napolitano, Daniela Russo, +9 authors, Stefania Staibano.
Cancers (Basel), 2021 Aug 08; 13(15). PMID: 34359721    Free PMC article.
A Means of Assessing Deep Learning-Based Detection of ICOS Protein Expression in Colon Cancer.
Md Mostafa Kamal Sarker, Yasmine Makhlouf, +6 authors, Perry Maxwell.
Cancers (Basel), 2021 Aug 08; 13(15). PMID: 34359723    Free PMC article.
Involvement of Innate Immune Receptors in the Resolution of Acute Hepatitis B in Woodchucks.
Manasa Suresh, Bin Li, +2 authors, Stephan Menne.
Front Immunol, 2021 Aug 10; 12. PMID: 34367179    Free PMC article.
Wnt/β-Catenin Inhibition Disrupts Carboplatin Resistance in Isogenic Models of Triple-Negative Breast Cancer.
Willy Antoni Abreu de Oliveira, Stijn Moens, +9 authors, Frederic Lluis.
Front Oncol, 2021 Aug 10; 11. PMID: 34367990    Free PMC article.
Chemotherapy Induces Tumor-Associated Macrophages that Aid Adaptive Immune Responses in Ovarian Cancer.
Owen Heath, Chiara Berlato, +9 authors, Frances R Balkwill.
Cancer Immunol Res, 2021 Apr 12; 9(6). PMID: 33839687    Free PMC article.
Increased mortality and altered local immune response in secondary peritonitis after previous visceral operations in mice.
Jonas Menz, Laura Hundt, +3 authors, Grazyna Domanska.
Sci Rep, 2021 Aug 12; 11(1). PMID: 34376743    Free PMC article.
Digital Pathology Scoring of Immunohistochemical Staining Reliably Identifies Prognostic Markers and Anatomical Associations in a Large Cohort of Oral Cancers.
Julius Moratin, Andreas Mock, +11 authors, Christian Freudlsperger.
Front Oncol, 2021 Aug 17; 11. PMID: 34395287    Free PMC article.
Pathophysiology of reflux oesophagitis: role of Toll-like receptors 2 and 4 and Farnesoid X receptor.
Minna Nortunen, Nina Väkiparta, +3 authors, Heikki Huhta.
Virchows Arch, 2021 Mar 10; 479(2). PMID: 33686512    Free PMC article.
Mid-pregnancy maternal immune activation increases Pax6-positive and Tbr2-positive neural progenitor cells and causes integrated stress response in the fetal brain in a mouse model of maternal viral infection.
Tsuyoshi Tsukada, Hiromi Sakata-Haga, +2 authors, Toshihisa Hatta.
IBRO Neurosci Rep, 2021 Aug 20; 11. PMID: 34409402    Free PMC article.
SIAL: A simple image analysis library for wet-lab scientists.
David R Tyrpak, Yaocun Li, Siqi Lei, J Andrew MacKay.
J Open Source Softw, 2020 Jan 01; 5(56). PMID: 34414350    Free PMC article.
MiR-205-driven downregulation of cholesterol biosynthesis through SQLE-inhibition identifies therapeutic vulnerability in aggressive prostate cancer.
C Kalogirou, J Linxweiler, +21 authors, A Schulze.
Nat Commun, 2021 Aug 22; 12(1). PMID: 34417456    Free PMC article.
Colonic epithelial cathelicidin (LL-37) expression intensity is associated with progression of colorectal cancer and presence of CD8+ T cell infiltrate.
Ross J Porter, Graeme I Murray, +7 authors, Mairi H McLean.
J Pathol Clin Res, 2021 May 15; 7(5). PMID: 33988317    Free PMC article.
Alternative splice variants of DCLK1 mark cancer stem cells, promote self-renewal and drug-resistance, and can be targeted to inhibit tumorigenesis in kidney cancer.
Yang Ge, Nathaniel Weygant, +13 authors, Courtney W Houchen.
Int J Cancer, 2018 Mar 27; 143(5). PMID: 29577277    Free PMC article.
IL-17 is expressed on beta and alpha cells of donors with type 1 and type 2 diabetes.
Sakthi Rajendran, Estefania Quesada-Masachs, +6 authors, Matthias von Herrath.
J Autoimmun, 2021 Aug 07; 123. PMID: 34358764    Free PMC article.
Identification of Novel Ligands for Targeted Antifibrotic Therapy of Chronic Pancreatitis.
Jessica Hung, Rohni Awasthi, Alexander L Klibanov, Kimberly A Kelly.
Int J Nanomedicine, 2021 Aug 26; 16. PMID: 34429596    Free PMC article.
Distinct immune microenvironment profiles of therapeutic responders emerge in combined TGFβ/PD-L1 blockade-treated squamous cell carcinoma.
Alexander A Strait, Rachel A Woolaver, +7 authors, Xiao-Jing Wang.
Commun Biol, 2021 Aug 27; 4(1). PMID: 34433873    Free PMC article.
A Diffusion-like Process Accommodates New Crypts During Clonal Expansion in Human Colonic Epithelium.
Cora Olpe, Doran Khamis, +12 authors, Edward Morrissey.
Gastroenterology, 2021 Apr 26; 161(2). PMID: 33895166    Free PMC article.
Digital Image Analysis for Estimating Stromal CD8+ Tumor-Infiltrating Lymphocytes in Lung Adenocarcinoma.
Iny Jhun, Daniel Shepherd, +3 authors, Mari Mino-Kenudson.
J Pathol Inform, 2021 Aug 28; 12. PMID: 34447608    Free PMC article.
Kallikrein-Related Peptidase 6 Is Associated with the Tumour Microenvironment of Pancreatic Ductal Adenocarcinoma.
Juliana B Candido, Oscar Maiques, +9 authors, Daniela Loessner.
Cancers (Basel), 2021 Aug 28; 13(16). PMID: 34439122    Free PMC article.
Context-Specific Efficacy of Apalutamide Therapy in Preclinical Models of Pten-Deficient Prostate Cancer.
Marco A De Velasco, Yurie Kura, +9 authors, Hirotsugu Uemura.
Cancers (Basel), 2021 Aug 28; 13(16). PMID: 34439133    Free PMC article.
Melatonin and Glycine Reduce Uterus Ischemia/Reperfusion Injury in a Rat Model of Warm Ischemia.
Viktorija Zitkute, Mindaugas Kvietkauskas, +5 authors, Peter Schemmer.
Int J Mol Sci, 2021 Aug 28; 22(16). PMID: 34445081    Free PMC article.
Nitric Oxide-Releasing Drug Glyceryl Trinitrate Targets JAK2/STAT3 Signaling, Migration and Invasion of Triple-Negative Breast Cancer Cells.
Sarra Bouaouiche, Silvia Ghione, +5 authors, Stéphanie Plenchette.
Int J Mol Sci, 2021 Aug 28; 22(16). PMID: 34445170    Free PMC article.
Single Dose of N-Acetylcysteine in Local Anesthesia Increases Expression of HIF1α, MAPK1, TGFβ1 and Growth Factors in Rat Wound Healing.
Wiktor Paskal, Michał Kopka, +8 authors, Paweł Włodarski.
Int J Mol Sci, 2021 Aug 28; 22(16). PMID: 34445365    Free PMC article.
Bordetella Adenylate Cyclase Toxin Elicits Airway Mucin Secretion through Activation of the cAMP Response Element Binding Protein.
Anna Malandra, Waheed Ur Rahman, +6 authors, Radim Osicka.
Int J Mol Sci, 2021 Aug 28; 22(16). PMID: 34445770    Free PMC article.
A new technological approach in diagnostic pathology: mass spectrometry imaging-based metabolomics for biomarker detection in urachal cancer.
Judith Martha Neumann, Karsten Niehaus, +8 authors, Henning Reis.
Lab Invest, 2021 May 23; 101(9). PMID: 34021261    Free PMC article.
Detecting Abnormal Neuronal Activity in a Chronic Migraine Model by Egr1-EGFP Transgenic Mice.
Fei Wang, Weiqing Jiang, +6 authors, Yonggang Wang.
Front Neurosci, 2021 Aug 31; 15. PMID: 34456674    Free PMC article.
ATG5 and ATG7 Expression Levels Are Reduced in Cutaneous Melanoma and Regulated by NRF1.
Živa Frangež, Deborah Gérard, +9 authors, Hans-Uwe Simon.
Front Oncol, 2021 Aug 31; 11. PMID: 34458153    Free PMC article.
Effect of High Hydrostatic Pressure on Human Trabecular Bone Regarding Cell Death and Matrix Integrity.
Janine Waletzko-Hellwig, Christopher Pohl, +5 authors, Rainer Bader.
Front Bioeng Biotechnol, 2021 Aug 31; 9. PMID: 34458245    Free PMC article.
Partial Inhibition of the 6-Phosphofructo-2-Kinase/Fructose-2,6-Bisphosphatase-3 (PFKFB3) Enzyme in Myeloid Cells Does Not Affect Atherosclerosis.
Renée J H A Tillie, Jenny De Bruijn, +8 authors, Judith C Sluimer.
Front Cell Dev Biol, 2021 Aug 31; 9. PMID: 34458258    Free PMC article.
Interleukin-1 blockade attenuates white matter inflammation and oligodendrocyte loss after progressive systemic lipopolysaccharide exposure in near-term fetal sheep.
Sharmony B Kelly, Vanesa Stojanovska, +11 authors, Robert Galinsky.
J Neuroinflammation, 2021 Sep 02; 18(1). PMID: 34465372    Free PMC article.
Synergistic targeting of BRCA1 mutated breast cancers with PARP and CDK2 inhibition.
Diar Aziz, Neil Portman, +15 authors, C Elizabeth Caldon.
NPJ Breast Cancer, 2021 Sep 02; 7(1). PMID: 34465787    Free PMC article.
Superpixel image segmentation of VISTA expression in colorectal cancer and its relationship to the tumoral microenvironment.
Dongling Wu, Sean Hacking, Taisia Vitkovski, Mansoor Nasim.
Sci Rep, 2021 Sep 02; 11(1). PMID: 34465822    Free PMC article.
Olfactory bulb astrocytes mediate sensory circuit processing through Sox9 in the mouse brain.
Kevin Ung, Teng-Wei Huang, +9 authors, Benjamin R Arenkiel.
Nat Commun, 2021 Sep 03; 12(1). PMID: 34471129    Free PMC article.
Morphological Estimation of Cellularity on Neo-Adjuvant Treated Breast Cancer Histological Images.
Mauricio Alberto Ortega-Ruiz, Cefa Karabağ, Victor García Garduño, Constantino Carlos Reyes-Aldasoro.
J Imaging, 2021 Aug 31; 6(10). PMID: 34460542    Free PMC article.
High Immunoexpression of COX-2 as a Metastatic Risk Factor in ccRCC without PD-L1 Involvement.
Sri Suryanti, Hasrayati Agustina, +3 authors, Lestari Putri.
Res Rep Urol, 2021 Sep 02; 13. PMID: 34466408    Free PMC article.
ONC212 is a Novel Mitocan Acting Synergistically with Glycolysis Inhibition in Pancreatic Cancer.
Isacco Ferrarini, Anna Louie, Lanlan Zhou, Wafik S El-Deiry.
Mol Cancer Ther, 2021 Jul 06; 20(9). PMID: 34224362    Free PMC article.
JunD, not c-Jun, is the AP-1 transcription factor required for Ras-induced lung cancer.
E Josue Ruiz, Linxiang Lan, +10 authors, Axel Behrens.
JCI Insight, 2021 Jul 09; 6(13). PMID: 34236045    Free PMC article.
A Synergistic Anticancer FAK and HDAC Inhibitor Combination Discovered by a Novel Chemical-Genetic High-Content Phenotypic Screen.
John C Dawson, Bryan Serrels, +7 authors, Margaret C Frame.
Mol Cancer Ther, 2019 Dec 01; 19(2). PMID: 31784455    Free PMC article.
Astrocytic glycogen accumulation drives the pathophysiology of neurodegeneration in Lafora disease.
Jordi Duran, Arnau Hervera, +6 authors, Joan J Guinovart.
Brain, 2021 Apr 07; 144(8). PMID: 33822008    Free PMC article.
Chitosan-Based Hydrogel for the Dual Delivery of Antimicrobial Agents Against Bacterial Methicillin-Resistant Staphylococcus aureus Biofilm-Infected Wounds.
Victoria O Fasiku, Calvin A Omolo, +6 authors, Thirumala Govender.
ACS Omega, 2021 Sep 10; 6(34). PMID: 34497894    Free PMC article.
Characterisation of lamina I anterolateral system neurons that express Cre in a Phox2a-Cre mouse line.
Wafa A A Alsulaiman, Raphaelle Quillet, +8 authors, Maria Gutierrez-Mecinas.
Sci Rep, 2021 Sep 11; 11(1). PMID: 34504158    Free PMC article.
Induction of the integrated stress response in the rat cornea.
C Peterson, Y C Kim, +2 authors, J Foster.
Exp Eye Res, 2021 Aug 10; 210. PMID: 34370978    Free PMC article.
Application of 3D MAPs pipeline identifies the morphological sequence chondrocytes undergo and the regulatory role of GDF5 in this process.
Sarah Rubin, Ankit Agrawal, +7 authors, Elazar Zelzer.
Nat Commun, 2021 Sep 12; 12(1). PMID: 34508093    Free PMC article.
Automated PD-L1 Scoring Using Artificial Intelligence in Head and Neck Squamous Cell Carcinoma.
Behrus Puladi, Mark Ooms, +6 authors, Till Braunschweig.
Cancers (Basel), 2021 Sep 11; 13(17). PMID: 34503218    Free PMC article.
Best Practices for Spatial Profiling for Breast Cancer Research with the GeoMx® Digital Spatial Profiler.
Helga Bergholtz, Jodi M Carter, +30 authors, On Behalf Of The GeoMx Breast Cancer Consortium.
Cancers (Basel), 2021 Sep 11; 13(17). PMID: 34503266    Free PMC article.
CellProfiler 4: improvements in speed, utility and usability.
David R Stirling, Madison J Swain-Bowden, +3 authors, Allen Goodman.
BMC Bioinformatics, 2021 Sep 12; 22(1). PMID: 34507520    Free PMC article.
Tumor budding correlates with tumor invasiveness and predicts worse survival in pT1 non-muscle-invasive bladder cancer.
Markus Eckstein, Charlotte Kimmel, +7 authors, Johannes Breyer.
Sci Rep, 2021 Sep 11; 11(1). PMID: 34504238    Free PMC article.
Investigation of Different Free Image Analysis Software for High-Throughput Droplet Detection.
Immanuel Sanka, Simona Bartkova, +2 authors, Ott Scheler.
ACS Omega, 2021 Sep 14; 6(35). PMID: 34514234    Free PMC article.
An "eat me" combinatory nano-formulation for systemic immunotherapy of solid tumors.
Hend Mohamed Abdel-Bar, Adam A Walters, +7 authors, Khuloud T Al-Jamal.
Theranostics, 2021 Sep 16; 11(18). PMID: 34522209    Free PMC article.
HistoClean: Open-source software for histological image pre-processing and augmentation to improve development of robust convolutional neural networks.
Kris D McCombe, Stephanie G Craig, +8 authors, Jacqueline A James.
Comput Struct Biotechnol J, 2021 Sep 16; 19. PMID: 34522291    Free PMC article.
Mapping of truncated O-glycans in cancers of epithelial and non-epithelial origin.
Troels Boldt Rømer, Mikkel Koed Møller Aasted, +6 authors, Hans Heugh Wandall.
Br J Cancer, 2021 Sep 17; 125(9). PMID: 34526666    Free PMC article.
Dual PD-L1 and TGF-b blockade in patients with recurrent respiratory papillomatosis.
Yvette Robbins, Jay Friedman, +10 authors, Scott Norberg.
J Immunother Cancer, 2021 Sep 01; 9(8). PMID: 34462327    Free PMC article.
Association between pathogenic germline mutations in BRCA2 and ATM and tumor-infiltrating lymphocytes in primary prostate cancer.
Harsimar B Kaur, Thiago Vidotto, +4 authors, Tamara L Lotan.
Cancer Immunol Immunother, 2021 Sep 18;. PMID: 34533610
Single-cell analysis defines a pancreatic fibroblast lineage that supports anti-tumor immunity.
Colin Hutton, Felix Heider, +24 authors, Claus Jørgensen.
Cancer Cell, 2021 Jul 24; 39(9). PMID: 34297917    Free PMC article.
Glial-Specific Deletion of Med12 Results in Rapid Hearing Loss via Degradation of the Stria Vascularis.
Teng-Wei Huang, Amrita A Iyer, +8 authors, Benjamin Deneen.
J Neurosci, 2021 Jul 14; 41(34). PMID: 34253626    Free PMC article.
Subcellular proteomics.
Josie A Christopher, Charlotte Stadler, +12 authors, Kathryn S Lilley.
Nat Rev Methods Primers, 2021 Sep 23; 1. PMID: 34549195    Free PMC article.
Augmin deficiency in neural stem cells causes p53-dependent apoptosis and aborts brain development.
Ricardo Viais, Marcos Fariña-Mosquera, +4 authors, Jens Lüders.
Elife, 2021 Aug 25; 10. PMID: 34427181    Free PMC article.
Feasibility and utility of MRI and dynamic 18F-FDG-PET in an orthotopic organoid-based patient-derived mouse model of endometrial cancer.
Heidi Espedal, Hege F Berg, +3 authors, Ingfrid S Haldorsen.
J Transl Med, 2021 Sep 28; 19(1). PMID: 34565386    Free PMC article.
Cancer immunotherapy: it's time to better predict patients' response.
Charlotte Pilard, Marie Ancion, +3 authors, Michael Herfs.
Br J Cancer, 2021 Jun 12; 125(7). PMID: 34112949    Free PMC article.
Review.
Molecular Features of Cancers Exhibiting Exceptional Responses to Treatment.
David A Wheeler, Naoko Takebe, +43 authors, Louis M Staudt.
Cancer Cell, 2020 Nov 21; 39(1). PMID: 33217343    Free PMC article.
Mutations in the transcription factor FOXO1 mimic positive selection signals to promote germinal center B cell expansion and lymphomagenesis.
Mark P Roberto, Gabriele Varano, +6 authors, David Dominguez-Sola.
Immunity, 2021 Aug 12; 54(8). PMID: 34380064    Free PMC article.
Development and validation of deep learning classifiers to detect Epstein-Barr virus and microsatellite instability status in gastric cancer: a retrospective multicentre cohort study.
Hannah Sophie Muti, Lara Rosaline Heij, +32 authors, Jakob Nikolas Kather.
Lancet Digit Health, 2021 Aug 22; 3(10). PMID: 34417147    Free PMC article.
Robust behavioural effects in response to acute, but not repeated, terpene administration in Zebrafish (Danio rerio).
Joshua Szaszkiewicz, Shannon Leigh, Trevor J Hamilton.
Sci Rep, 2021 Sep 30; 11(1). PMID: 34584156    Free PMC article.
Pixelwise H-score: A novel digital image analysis-based metric to quantify membrane biomarker expression from immunohistochemistry images.
Sripad Ram, Pamela Vizcarra, +6 authors, Eric L Powell.
PLoS One, 2021 Sep 28; 16(9). PMID: 34570796    Free PMC article.
A Novel Monoclonal Antibody Targeting Cancer-Specific Plectin Has Potent Antitumor Activity in Ovarian Cancer.
Samantha M Perez, Julien Dimastromatteo, Charles N Landen, Kimberly A Kelly.
Cells, 2021 Sep 29; 10(9). PMID: 34571866    Free PMC article.
Use of MALDI Mass Spectrometry Imaging to Identify Proteomic Signatures in Aortic Aneurysms after Endovascular Repair.
Matthias Buerger, Oliver Klein, +10 authors, Irene Hinterseher.
Biomedicines, 2021 Sep 29; 9(9). PMID: 34572274    Free PMC article.
Shifting Gears in Precision Oncology-Challenges and Opportunities of Integrative Data Analysis.
Ka-Won Noh, Reinhard Buettner, Sebastian Klein.
Biomolecules, 2021 Sep 29; 11(9). PMID: 34572523    Free PMC article.
Review.
High Numbers of CD163-Positive Macrophages in the Fibrotic Region of Exuberant Granulation Tissue in Horses.
Charis Du Cheyne, Ann Martens, Ward De Spiegelaere.
Animals (Basel), 2021 Sep 29; 11(9). PMID: 34573694    Free PMC article.
CD146 Delineates an Interfascicular Cell Sub-Population in Tendon That Is Recruited during Injury through Its Ligand Laminin-α4.
Neil Marr, Richard Meeson, +5 authors, Chavaunne T Thorpe.
Int J Mol Sci, 2021 Sep 29; 22(18). PMID: 34575887    Free PMC article.
DeepHistoClass: A Novel Strategy for Confident Classification of Immunohistochemistry Images Using Deep Learning.
Biraja Ghoshal, Feria Hikmet, +2 authors, Cecilia Lindskog.
Mol Cell Proteomics, 2021 Aug 24; 20. PMID: 34425263    Free PMC article.
Cancer Cells Retrace a Stepwise Differentiation Program during Malignant Progression.
Sadegh Saghafinia, Krisztian Homicsko, +6 authors, Douglas Hanahan.
Cancer Discov, 2021 Apr 30; 11(10). PMID: 33910926    Free PMC article.
Induction of APOBEC3 Exacerbates DNA Replication Stress and Chromosomal Instability in Early Breast and Lung Cancer Evolution.
Subramanian Venkatesan, Mihaela Angelova, +44 authors, TRACERx Consortium.
Cancer Discov, 2021 May 06; 11(10). PMID: 33947663    Free PMC article.
The Effects of COVID-19 on the Placenta During Pregnancy.
Habib Sadeghi Rad, Joan Röhl, +6 authors, Arutha Kulasinghe.
Front Immunol, 2021 Oct 05; 12. PMID: 34603330    Free PMC article.
Review.
Sex-specific parenting and depression evoked by preoptic inhibitory neurons.
Diána Dimén, Gina Puska, +3 authors, Árpád Dobolyi.
iScience, 2021 Oct 05; 24(10). PMID: 34604722    Free PMC article.

;. PMID: 34611159
Coxiella burnetii Whole Cell Vaccine Produces a Th1 Delayed-Type Hypersensitivity Response in a Novel Sensitized Mouse Model.
Alycia P Fratzke, Anthony E Gregory, Erin J van Schaik, James E Samuel.
Front Immunol, 2021 Oct 08; 12. PMID: 34616410    Free PMC article.
TRIP6 functions in brain ciliogenesis.
Shalmali Shukla, Ronny Haenold, +11 authors, Peter Herrlich.
Nat Commun, 2021 Oct 09; 12(1). PMID: 34620853    Free PMC article.
Intravital imaging technology guides FAK-mediated priming in pancreatic cancer precision medicine according to Merlin status.
Kendelle J Murphy, Daniel A Reed, +46 authors, Paul Timpson.
Sci Adv, 2021 Sep 30; 7(40). PMID: 34586840    Free PMC article.
Leveraging the Treg-intrinsic CTLA4-PKCη signaling pathway for cancer immunotherapy.
Hsin-Yu Liu, Christophe Pedros, +3 authors, Amnon Altman.
J Immunother Cancer, 2021 Oct 01; 9(9). PMID: 34588224    Free PMC article.
Fluorescent Multiplex Immunohistochemistry Coupled With Other State-Of-The-Art Techniques to Systematically Characterize the Tumor Immune Microenvironment.
Anaïs Boisson, Grégory Noël, +12 authors, Soizic Garaud.
Front Mol Biosci, 2021 Oct 09; 8. PMID: 34621785    Free PMC article.
Predictive models of response to neoadjuvant chemotherapy in muscle-invasive bladder cancer using nuclear morphology and tissue architecture.
Haoyang Mi, Trinity J Bivalacqua, +4 authors, Alexander S Baras.
Cell Rep Med, 2021 Oct 09; 2(9). PMID: 34622225    Free PMC article.
Single-cell RNA-seq unravels alterations of the human spermatogonial stem cell compartment in patients with impaired spermatogenesis.
Sara Di Persio, Tobias Tekath, +12 authors, Nina Neuhaus.
Cell Rep Med, 2021 Oct 09; 2(9). PMID: 34622232    Free PMC article.
Biological data annotation via a human-augmenting AI-based labeling system.
Douwe van der Wal, Iny Jhun, +11 authors, Andre Esteva.
NPJ Digit Med, 2021 Oct 09; 4(1). PMID: 34620993    Free PMC article.
β2-adrenergic receptor expression and the effects of norepinephrine and propranolol on various head and neck cancer subtypes.
Soon Young Kwon, Kyung Ju Chun, +6 authors, Min-Su Kim.
Oncol Lett, 2021 Oct 12; 22(5). PMID: 34630711    Free PMC article.
Artificial Intelligence and Cellular Segmentation in Tissue Microscopy Images.
Madeleine S Durkee, Rebecca Abraham, Marcus R Clark, Maryellen L Giger.
Am J Pathol, 2021 Jun 16; 191(10). PMID: 34129842    Free PMC article.
Review.
Viability fingerprint of glioblastoma cell lines: roles of mitotic, proliferative, and epigenetic targets.
Darja Lavogina, Tõnis Laasfeld, +2 authors, Jana Jaal.
Sci Rep, 2021 Oct 15; 11(1). PMID: 34645858    Free PMC article.
Senescence markers in focal nodular hyperplasia of the liver: pathogenic considerations on the basis of immunohistochemical results.
Helmut Denk, Daniela Pabst, +4 authors, Carolin Lackner.
Mod Pathol, 2021 Oct 15;. PMID: 34645984
Neural control of affiliative touch in prosocial interaction.
Ye Emily Wu, James Dang, +4 authors, Weizhe Hong.
Nature, 2021 Oct 15;. PMID: 34646019
The CD155/TIGIT axis promotes and maintains immune evasion in neoantigen-expressing pancreatic cancer.
William A Freed-Pastor, Laurens J Lambert, +21 authors, Tyler Jacks.
Cancer Cell, 2021 Aug 07; 39(10). PMID: 34358448    Free PMC article.
Distinct mutational profile and immune microenvironment in microsatellite-unstable and POLE-mutated tumors.
Hee Sang Hwang, Deokhoon Kim, Jene Choi.
J Immunother Cancer, 2021 Oct 06; 9(10). PMID: 34607897    Free PMC article.
Tryptophan metabolism is inversely regulated in the tumor and blood of patients with glioblastoma.
Verena Panitz, Saša Končarević, +25 authors, Christiane A Opitz.
Theranostics, 2021 Oct 15; 11(19). PMID: 34646367    Free PMC article.
Analysis of Telomere Maintenance Related Genes Reveals NOP10 as a New Metastatic-Risk Marker in Pheochromocytoma/Paraganglioma.
María Monteagudo, Paula Martínez, +35 authors, Mercedes Robledo.
Cancers (Basel), 2021 Oct 14; 13(19). PMID: 34638246    Free PMC article.
Therapeutic Effects of Inhibition of Sphingosine-1-Phosphate Signaling in HIF-2α Inhibitor-Resistant Clear Cell Renal Cell Carcinoma.
Rouven Hoefflin, Sabine Harlander, +14 authors, Ian J Frew.
Cancers (Basel), 2021 Oct 14; 13(19). PMID: 34638286    Free PMC article.
Evolution of the Tumor Microenvironment toward Immune-Suppressive Seclusion during Brain Metastasis of Breast Cancer: Implications for Targeted Therapy.
Myung-Giun Noh, Sung Sun Kim, +9 authors, Kyung-Hwa Lee.
Cancers (Basel), 2021 Oct 14; 13(19). PMID: 34638378    Free PMC article.
EZH2 Inhibition as New Epigenetic Treatment Option for Pancreatic Neuroendocrine Neoplasms (PanNENs).
Simon Leonhard April-Monn, Valentina Andreasi, +13 authors, Ilaria Marinoni.
Cancers (Basel), 2021 Oct 14; 13(19). PMID: 34638497    Free PMC article.
Effects of maternal diet-induced obesity on metabolic disorders and age-associated miRNA expression in the liver of male mouse offspring.
Laís Vales Mennitti, Asha A M Carpenter, +9 authors, Susan E Ozanne.
Int J Obes (Lond), 2021 Oct 20;. PMID: 34663892
Excision of mutagenic replication-blocking lesions suppresses cancer but promotes cytotoxicity and lethality in nitrosamine-exposed mice.
Jennifer E Kay, Joshua J Corrigan, +12 authors, Bevin P Engelward.
Cell Rep, 2021 Mar 18; 34(11). PMID: 33730582    Free PMC article.
Quick Annotator: an open-source digital pathology based rapid image annotation tool.
Runtian Miao, Robert Toth, +2 authors, Andrew Janowczyk.
J Pathol Clin Res, 2021 Jul 22; 7(6). PMID: 34288586    Free PMC article.
Machine Learning of Bone Marrow Histopathology Identifies Genetic and Clinical Determinants in Patients with MDS.
Oscar E Brück, Susanna E Lallukka-Brück, +8 authors, Satu M Mustjoki.
Blood Cancer Discov, 2021 Oct 19; 2(3). PMID: 34661156    Free PMC article.
Deep learning reveals disease-specific signatures of white matter pathology in tauopathies.
Anthony R Vega, Rati Chkheidze, +5 authors, Satwik Rajaram.
Acta Neuropathol Commun, 2021 Oct 23; 9(1). PMID: 34674762    Free PMC article.
An Open-Source, Automated Tumor-Infiltrating Lymphocyte Algorithm for Prognosis in Triple-Negative Breast Cancer.
Yalai Bai, Kimberly Cole, +9 authors, David L Rimm.
Clin Cancer Res, 2021 Jun 06; 27(20). PMID: 34088723    Free PMC article.
Robust whole slide image analysis for cervical cancer screening using deep learning.
Shenghua Cheng, Sibo Liu, +20 authors, Xiuli Liu.
Nat Commun, 2021 Sep 26; 12(1). PMID: 34561435    Free PMC article.
Newly regenerated axons via scaffolds promote sub-lesional reorganization and motor recovery with epidural electrical stimulation.
Ahad M Siddiqui, Riazul Islam, +17 authors, Igor A Lavrov.
NPJ Regen Med, 2021 Oct 22; 6(1). PMID: 34671050    Free PMC article.
Expression of p53, p63, podoplanin and Ki-67 in recurring versus non-recurring oral leukoplakia.
Jonas Sundberg, Sushma Pandey, +8 authors, Bengt Hasséus.
Sci Rep, 2021 Oct 23; 11(1). PMID: 34675318    Free PMC article.
In Situ Hybridization of PRRSV-1 Combined with Digital Image Analysis in Lung Tissues of Pigs Challenged with PRRSV-1.
Lilla Dénes, Dávid G Horváth, +8 authors, Gyula Balka.
Vet Sci, 2021 Oct 23; 8(10). PMID: 34679065    Free PMC article.
Immunoprofiles and DNA Methylation of Inflammatory Marker Genes in Ulcerative Colitis-Associated Colorectal Tumorigenesis.
Satu Mäki-Nevala, Sanjeevi Ukwattage, +6 authors, Päivi Peltomäki.
Biomolecules, 2021 Oct 24; 11(10). PMID: 34680073    Free PMC article.
BRAF Mutant Allele Frequency (MAF) Influences Melanoma Clinicopathologic Characteristics.
Xavier Soria, Felip Vilardell, +11 authors, Rosa M Martí.
Cancers (Basel), 2021 Oct 24; 13(20). PMID: 34680222    Free PMC article.
Comprehensive Analysis of VEGFR2 Expression in HPV-Positive and -Negative OPSCC Reveals Differing VEGFR2 Expression Patterns.
Senem Uzun, Yüksel Korkmaz, +8 authors, Christian U Huebbers.
Cancers (Basel), 2021 Oct 24; 13(20). PMID: 34680369    Free PMC article.
Spatio-Temporal Multiscale Analysis of Western Diet-Fed Mice Reveals a Translationally Relevant Sequence of Events during NAFLD Progression.
Ahmed Ghallab, Maiju Myllys, +32 authors, Jan G Hengstler.
Cells, 2021 Oct 24; 10(10). PMID: 34685496    Free PMC article.
Functional Proteomic Profiling of Triple-Negative Breast Cancer.
Irina Gromova, Jaime A Espinoza, +4 authors, José M A Moreira.
Cells, 2021 Oct 24; 10(10). PMID: 34685748    Free PMC article.
Qualitative Histopathological Classification of Primary Bone Tumors Using Deep Learning: A Pilot Study.
Yuzhang Tao, Xiao Huang, +16 authors, Jian Zhang.
Front Oncol, 2021 Oct 26; 11. PMID: 34692509    Free PMC article.
Assessment of PARP4 as a candidate breast cancer susceptibility gene.
Aldo Prawira, Prabhakaran Munusamy, +8 authors, Ann Siew Gek Lee.
Breast Cancer Res Treat, 2019 May 24; 177(1). PMID: 31119570
Immunogenomics of Colorectal Cancer Response to Checkpoint Blockade: Analysis of the KEYNOTE 177 Trial and Validation Cohorts.
Michele Bortolomeazzi, Mohamed Reda Keddar, +26 authors, Francesca D Ciccarelli.
Gastroenterology, 2021 Jul 02; 161(4). PMID: 34197832    Free PMC article.
Pancreatic Cancer Chemotherapy Is Potentiated by Induction of Tertiary Lymphoid Structures in Mice.
Francesca R Delvecchio, Rachel E A Fincham, +8 authors, Hemant M Kocher.
Cell Mol Gastroenterol Hepatol, 2021 Jul 13; 12(5). PMID: 34252585    Free PMC article.
Therapeutic inhibition of USP9x-mediated Notch signaling in triple-negative breast cancer.
Arushi Jaiswal, Kiichi Murakami, +6 authors, Michael Reedijk.
Proc Natl Acad Sci U S A, 2021 Sep 15; 118(38). PMID: 34518219    Free PMC article.
TIMP1 expression underlies sex disparity in liver metastasis and survival in pancreatic cancer.
Chris D Hermann, Benjamin Schoeps, +12 authors, Achim Krüger.
J Exp Med, 2021 Sep 18; 218(11). PMID: 34533565    Free PMC article.
Tutorial: methods for three-dimensional visualization of archival tissue material.
Tariq Sami Haddad, Peter Friedl, +3 authors, Iris Nagtegaal.
Nat Protoc, 2021 Oct 31; 16(11). PMID: 34716449
Review.
Daily caloric restriction limits tumor growth more effectively than caloric cycling regardless of dietary composition.
Laura C D Pomatto-Watson, Monica Bodogai, +16 authors, Rafael de Cabo.
Nat Commun, 2021 Oct 29; 12(1). PMID: 34707136    Free PMC article.
Multi-omics analysis identifies therapeutic vulnerabilities in triple-negative breast cancer subtypes.
Brian D Lehmann, Antonio Colaprico, +12 authors, X Steven Chen.
Nat Commun, 2021 Nov 03; 12(1). PMID: 34725325
Multiplexed immunofluorescence identifies high stromal CD68+PD-L1+ macrophages as a predictor of improved survival in triple negative breast cancer.
James Wang, Lois Browne, +7 authors, Ewan K A Millar.
Sci Rep, 2021 Nov 05; 11(1). PMID: 34732817    Free PMC article.
AXL Inhibition in Macrophages Stimulates Host-versus-Leukemia Immunity and Eradicates Naïve and Treatment-Resistant Leukemia.
Irene Tirado-Gonzalez, Arnaud Descot, +34 authors, Hind Medyouf.
Cancer Discov, 2021 Jun 10; 11(11). PMID: 34103328    Free PMC article.
Preclinical Evaluation of Recombinant Microbial Glycoside Hydrolases in the Prevention of Experimental Invasive Aspergillosis.
Hanna Ostapska, Deepa Raju, +10 authors, Donald C Sheppard.
mBio, 2021 Sep 29; 12(5). PMID: 34579578    Free PMC article.
Developmental role of PHD2 in the pathogenesis of pseudohypoxic pheochromocytoma.
Luise Eckardt, Maria Prange-Barczynska, +7 authors, Tammie Bishop.
Endocr Relat Cancer, 2021 Oct 19; 28(12). PMID: 34658364    Free PMC article.
An immune-humanized patient-derived xenograft model of estrogen-independent, hormone receptor positive metastatic breast cancer.
Sandra D Scherer, Alessandra I Riggio, +9 authors, Alana L Welm.
Breast Cancer Res, 2021 Nov 01; 23(1). PMID: 34717714    Free PMC article.
New Artificial Intelligence Score and Immune Infiltrates as Prognostic Factors in Colorectal Cancer With Brain Metastases.
Violaine Randrian, Amandine Desette, +7 authors, David Tougeron.
Front Immunol, 2021 Nov 05; 12. PMID: 34733283    Free PMC article.
Kinomics platform using GBM tissue identifies BTK as being associated with higher patient survival.
Sofian Al Shboul, Olimpia E Curran, +10 authors, Paul M Brennan.
Life Sci Alliance, 2021 Oct 15; 4(12). PMID: 34645618    Free PMC article.
Myeloperoxidase and Other Markers of Neutrophil Activation Associate With Malaria and Malaria/HIV Coinfection in the Human Placenta.
Demba Sarr, Lilian J Oliveira, +8 authors, Julie M Moore.
Front Immunol, 2021 Nov 06; 12. PMID: 34737733    Free PMC article.