. 2017 Dec; 18(2):69-88.
doi: 10.1038/nrc.2017.105.

Ubiquitin ligases in oncogenic transformation and cancer therapy

Daniela Senft 1 Jianfei Qi 2 Ze'ev A Ronai 1 
  • PMID: 29242641
  •     211 References
  •     100 citations


The cellular response to external stress signals and DNA damage depends on the activity of ubiquitin ligases (E3s), which regulate numerous cellular processes, including homeostasis, metabolism and cell cycle progression. E3s recognize, interact with and ubiquitylate protein substrates in a temporally and spatially regulated manner. The topology of the ubiquitin chains dictates the fate of the substrates, marking them for recognition and degradation by the proteasome or altering their subcellular localization or assembly into functional complexes. Both genetic and epigenetic alterations account for the deregulation of E3s in cancer. Consequently, the stability and/or activity of E3 substrates are also altered, in some cases leading to downregulation of tumour-suppressor activities and upregulation of oncogenic activities. A better understanding of the mechanisms underlying E3 regulation and function in tumorigenesis is expected to identify novel prognostic markers and to enable the development of the next generation of anticancer therapies. This Review summarizes the oncogenic and tumour-suppressor roles of selected E3s and highlights novel opportunities for therapeutic intervention.

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Yusuke Sato, Tetsuichi Yoshizato, +26 authors, Seishi Ogawa.
Nat Genet, 2013 Jun 26; 45(8). PMID: 23797736
Highly Cited.
PTEN counteracts FBXL2 to promote IP3R3- and Ca2+-mediated apoptosis limiting tumour growth.
Shafi Kuchay, Carlotta Giorgi, +11 authors, Michele Pagano.
Nature, 2017 Jun 15; 546(7659). PMID: 28614300    Free PMC article.
Highly Cited.
Inhibition of Siah2 ubiquitin ligase by vitamin K3 (menadione) attenuates hypoxia and MAPK signaling and blocks melanoma tumorigenesis.
Meera Shah, John L Stebbins, +3 authors, Ze'ev A Ronai.
Pigment Cell Melanoma Res, 2009 Aug 29; 22(6). PMID: 19712206    Free PMC article.
Mitochondrial Ca(2+) and apoptosis.
Carlotta Giorgi, Federica Baldassari, +9 authors, Paolo Pinton.
Cell Calcium, 2012 Apr 07; 52(1). PMID: 22480931    Free PMC article.
Highly Cited. Review.
FBXW7/hCDC4 is a general tumor suppressor in human cancer.
Shahab Akhoondi, Dahui Sun, +24 authors, Charles Spruck.
Cancer Res, 2007 Oct 03; 67(19). PMID: 17909001
Highly Cited.
SKP2 is required for ubiquitin-mediated degradation of the CDK inhibitor p27.
A C Carrano, E Eytan, A Hershko, M Pagano.
Nat Cell Biol, 1999 Nov 13; 1(4). PMID: 10559916
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Methylation of the KEAP1 gene promoter region in human colorectal cancer.
Naoyuki Hanada, Takenori Takahata, +9 authors, Yasuo Saijo.
BMC Cancer, 2012 Feb 14; 12. PMID: 22325485    Free PMC article.
Exome sequencing of serous endometrial tumors identifies recurrent somatic mutations in chromatin-remodeling and ubiquitin ligase complex genes.
Matthieu Le Gallo, Andrea J O'Hara, +13 authors, Daphne W Bell.
Nat Genet, 2012 Oct 30; 44(12). PMID: 23104009    Free PMC article.
Highly Cited.
The ubiquitin ligase FBXW7 modulates leukemia-initiating cell activity by regulating MYC stability.
Bryan King, Thomas Trimarchi, +11 authors, Iannis Aifantis.
Cell, 2013 Jun 26; 153(7). PMID: 23791182    Free PMC article.
Highly Cited.
SCFbeta-TRCP controls oncogenic transformation and neural differentiation through REST degradation.
Thomas F Westbrook, Guang Hu, +8 authors, Stephen J Elledge.
Nature, 2008 Mar 21; 452(7185). PMID: 18354483    Free PMC article.
Highly Cited.
Phosphorylation by casein kinase I promotes the turnover of the Mdm2 oncoprotein via the SCF(beta-TRCP) ubiquitin ligase.
Hiroyuki Inuzuka, Alan Tseng, +15 authors, Wenyi Wei.
Cancer Cell, 2010 Aug 17; 18(2). PMID: 20708156    Free PMC article.
Highly Cited.
OTUB1 triggers lung cancer development by inhibiting RAS monoubiquitination.
Maria Francesca Baietti, Michal Simicek, +8 authors, Anna A Sablina.
EMBO Mol Med, 2016 Feb 18; 8(3). PMID: 26881969    Free PMC article.
Fbxw7/Cdc4 is a p53-dependent, haploinsufficient tumour suppressor gene.
Jian-Hua Mao, Jesus Perez-Losada, +6 authors, Allan Balmain.
Nature, 2004 Dec 14; 432(7018). PMID: 15592418
Highly Cited.
The linear ubiquitin chain assembly complex regulates TRAIL-induced gene activation and cell death.
Elodie Lafont, Chahrazade Kantari-Mimoun, +9 authors, Henning Walczak.
EMBO J, 2017 Mar 05; 36(9). PMID: 28258062    Free PMC article.
Highly Cited.
BTB protein Keap1 targets antioxidant transcription factor Nrf2 for ubiquitination by the Cullin 3-Roc1 ligase.
Manabu Furukawa, Yue Xiong.
Mol Cell Biol, 2004 Dec 17; 25(1). PMID: 15601839    Free PMC article.
Highly Cited.
Role of the F-box protein Skp2 in adhesion-dependent cell cycle progression.
A C Carrano, M Pagano.
J Cell Biol, 2001 Jun 27; 153(7). PMID: 11425869    Free PMC article.
FBXW7 influences murine intestinal homeostasis and cancer, targeting Notch, Jun, and DEK for degradation.
Roya Babaei-Jadidi, Ningning Li, +12 authors, Abdolrahman Shams Nateri.
J Exp Med, 2011 Feb 02; 208(2). PMID: 21282377    Free PMC article.
PARK2 deletions occur frequently in sporadic colorectal cancer and accelerate adenoma development in Apc mutant mice.
George Poulogiannis, Rebecca E McIntyre, +8 authors, Mark J Arends.
Proc Natl Acad Sci U S A, 2010 Aug 11; 107(34). PMID: 20696900    Free PMC article.
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Somatic mutations of the Parkinson's disease-associated gene PARK2 in glioblastoma and other human malignancies.
Selvaraju Veeriah, Barry S Taylor, +18 authors, Timothy A Chan.
Nat Genet, 2009 Dec 01; 42(1). PMID: 19946270    Free PMC article.
Highly Cited.
FBXL2- and PTPL1-mediated degradation of p110-free p85β regulatory subunit controls the PI(3)K signalling cascade.
Shafi Kuchay, Shanshan Duan, +5 authors, Michele Pagano.
Nat Cell Biol, 2013 Apr 23; 15(5). PMID: 23604317    Free PMC article.
Inhibition of RAS-mediated transformation and tumorigenesis by targeting the downstream E3 ubiquitin ligase seven in absentia homologue.
Rebecca L Schmidt, Cheol Hong Park, +5 authors, Amy H Tang.
Cancer Res, 2007 Dec 20; 67(24). PMID: 18089810
Pharmacological inactivation of Skp2 SCF ubiquitin ligase restricts cancer stem cell traits and cancer progression.
Chia-Hsin Chan, John Kenneth Morrow, +11 authors, Hui-Kuan Lin.
Cell, 2013 Aug 06; 154(3). PMID: 23911321    Free PMC article.
Highly Cited.
Parkin as a tumor suppressor gene for hepatocellular carcinoma.
M Fujiwara, H Marusawa, +7 authors, T Chiba.
Oncogene, 2008 Jun 25; 27(46). PMID: 18574468
Integrative and comparative genomic analysis of lung squamous cell carcinomas in East Asian patients.
Youngwook Kim, Peter S Hammerman, +31 authors, Keunchil Park.
J Clin Oncol, 2013 Dec 11; 32(2). PMID: 24323028    Free PMC article.
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Hypoxia regulates Hippo signalling through the SIAH2 ubiquitin E3 ligase.
Biao Ma, Yan Chen, +10 authors, Shian Wu.
Nat Cell Biol, 2014 Dec 02; 17(1). PMID: 25438054
Highly Cited.
Skp2 regulates Myc protein stability and activity.
So Young Kim, Andreas Herbst, +2 authors, William P Tansey.
Mol Cell, 2003 May 29; 11(5). PMID: 12769843
Highly Cited.
Initial genome sequencing and analysis of multiple myeloma.
Michael A Chapman, Michael S Lawrence, +47 authors, Todd R Golub.
Nature, 2011 Mar 25; 471(7339). PMID: 21430775    Free PMC article.
Highly Cited.
BAP1 regulates IP3R3-mediated Ca2+ flux to mitochondria suppressing cell transformation.
Angela Bononi, Carlotta Giorgi, +22 authors, Michele Carbone.
Nature, 2017 Jun 15; 546(7659). PMID: 28614305    Free PMC article.
Highly Cited.
The E3 ubiquitin ligase Siah2 contributes to castration-resistant prostate cancer by regulation of androgen receptor transcriptional activity.
Jianfei Qi, Manisha Tripathi, +11 authors, Ze'ev A Ronai.
Cancer Cell, 2013 Mar 23; 23(3). PMID: 23518348    Free PMC article.
Highly Cited.
SCFbetaTrCP-mediated degradation of Claspin regulates recovery from the DNA replication checkpoint response.
Angelo Peschiaroli, N Valerio Dorrello, +4 authors, Michele Pagano.
Mol Cell, 2006 Aug 04; 23(3). PMID: 16885022
Highly Cited.
Parkin and mitophagy in cancer.
J P Bernardini, M Lazarou, G Dewson.
Oncogene, 2016 Sep 07; 36(10). PMID: 27593930
Highly Cited. Review.
Regulated degradation of FANCM in the Fanconi anemia pathway during mitosis.
Younghoon Kee, Jung Min Kim, Alan D D'Andrea, Alan D'Andrea.
Genes Dev, 2009 Mar 10; 23(5). PMID: 19270156    Free PMC article.
UBQLN2 Mediates Autophagy-Independent Protein Aggregate Clearance by the Proteasome.
Roland Hjerpe, John S Bett, +14 authors, Thimo Kurz.
Cell, 2016 Aug 02; 166(4). PMID: 27477512    Free PMC article.
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A noncanonical mechanism of Nrf2 activation by autophagy deficiency: direct interaction between Keap1 and p62.
Alexandria Lau, Xiao-Jun Wang, +6 authors, Donna D Zhang.
Mol Cell Biol, 2010 Apr 28; 30(13). PMID: 20421418    Free PMC article.
Highly Cited.
Mule Regulates the Intestinal Stem Cell Niche via the Wnt Pathway and Targets EphB3 for Proteasomal and Lysosomal Degradation.
Carmen Dominguez-Brauer, Zhenyue Hao, +22 authors, Tak W Mak.
Cell Stem Cell, 2016 May 18; 19(2). PMID: 27184401    Free PMC article.
FBXW7 Facilitates Nonhomologous End-Joining via K63-Linked Polyubiquitylation of XRCC4.
Qiang Zhang, David Karnak, +3 authors, Yi Sun.
Mol Cell, 2016 Jan 18; 61(3). PMID: 26774286    Free PMC article.
Akt enhances Mdm2-mediated ubiquitination and degradation of p53.
Yoko Ogawara, Shohei Kishishita, +5 authors, Yukiko Gotoh.
J Biol Chem, 2002 Mar 30; 277(24). PMID: 11923280
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MDM2, MDMX and p53 in oncogenesis and cancer therapy.
Mark Wade, Yao-Cheng Li, Geoffrey M Wahl.
Nat Rev Cancer, 2013 Jan 11; 13(2). PMID: 23303139    Free PMC article.
Highly Cited. Review.
Parkin Regulates Mitosis and Genomic Stability through Cdc20/Cdh1.
Seung Baek Lee, Jung Jin Kim, +19 authors, Zhenkun Lou.
Mol Cell, 2015 Sep 22; 60(1). PMID: 26387737    Free PMC article.
M-phase kinases induce phospho-dependent ubiquitination of somatic Wee1 by SCFbeta-TrCP.
Nobumoto Watanabe, Harumi Arai, +4 authors, Hiroyuki Osada.
Proc Natl Acad Sci U S A, 2004 Apr 09; 101(13). PMID: 15070733    Free PMC article.
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KEAP1 gene mutations and NRF2 activation are common in pulmonary papillary adenocarcinoma.
Qing Kay Li, Anju Singh, +2 authors, Edward Gabrielson.
J Hum Genet, 2011 Jan 21; 56(3). PMID: 21248763    Free PMC article.
FBXW7 targets mTOR for degradation and cooperates with PTEN in tumor suppression.
Jian-Hua Mao, Il-Jin Kim, +4 authors, Allan Balmain.
Science, 2008 Sep 13; 321(5895). PMID: 18787170    Free PMC article.
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Siah2 regulates stability of prolyl-hydroxylases, controls HIF1alpha abundance, and modulates physiological responses to hypoxia.
Koh Nakayama, Ian J Frew, +9 authors, Ze'ev Ronai.
Cell, 2004 Jun 24; 117(7). PMID: 15210114
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Parkin, a p53 target gene, mediates the role of p53 in glucose metabolism and the Warburg effect.
Cen Zhang, Meihua Lin, +5 authors, Zhaohui Feng.
Proc Natl Acad Sci U S A, 2011 Sep 21; 108(39). PMID: 21930938    Free PMC article.
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Targeting mitotic exit leads to tumor regression in vivo: Modulation by Cdk1, Mastl, and the PP2A/B55α,δ phosphatase.
Eusebio Manchado, María Guillamot, +7 authors, Marcos Malumbres.
Cancer Cell, 2010 Dec 16; 18(6). PMID: 21156286
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V600E B-Raf requires the Hsp90 chaperone for stability and is degraded in response to Hsp90 inhibitors.
O M Grbovic, A D Basso, +4 authors, N Rosen.
Proc Natl Acad Sci U S A, 2005 Dec 24; 103(1). PMID: 16371460    Free PMC article.
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SCF(FBW7) regulates cellular apoptosis by targeting MCL1 for ubiquitylation and destruction.
Hiroyuki Inuzuka, Shavali Shaik, +17 authors, Wenyi Wei.
Nature, 2011 Mar 04; 471(7336). PMID: 21368833    Free PMC article.
Highly Cited.
Fbxw7α- and GSK3-mediated degradation of p100 is a pro-survival mechanism in multiple myeloma.
Luca Busino, Scott E Millman, +6 authors, Michele Pagano.
Nat Cell Biol, 2012 Mar 06; 14(4). PMID: 22388891    Free PMC article.
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Germline mutations in FH predispose to dominantly inherited uterine fibroids, skin leiomyomata and papillary renal cell cancer.
Ian P M Tomlinson, N Afrina Alam, +29 authors, Multiple Leiomyoma Consortium.
Nat Genet, 2002 Feb 28; 30(4). PMID: 11865300
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p62- and ubiquitin-dependent stress-induced autophagy of the mammalian 26S proteasome.
Victoria Cohen-Kaplan, Ido Livneh, +4 authors, Aaron Ciechanover.
Proc Natl Acad Sci U S A, 2016 Oct 30; 113(47). PMID: 27791183    Free PMC article.
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H2A-DUBbing the mammalian epigenome: expanding frontiers for histone H2A deubiquitinating enzymes in cell biology and physiology.
Jad I Belle, Anastasia Nijnik.
Int J Biochem Cell Biol, 2014 Mar 22; 50. PMID: 24647359
BRCA1 tumor suppression depends on BRCT phosphoprotein binding, but not its E3 ligase activity.
Reena Shakya, Latarsha J Reid, +11 authors, Thomas Ludwig.
Science, 2011 Oct 29; 334(6055). PMID: 22034435    Free PMC article.
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An antioxidant response phenotype shared between hereditary and sporadic type 2 papillary renal cell carcinoma.
Aikseng Ooi, Jing-Chii Wong, +14 authors, Kyle A Furge.
Cancer Cell, 2011 Oct 22; 20(4). PMID: 22014576
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Truncated ERG Oncoproteins from TMPRSS2-ERG Fusions Are Resistant to SPOP-Mediated Proteasome Degradation.
Jian An, Shancheng Ren, +20 authors, Haojie Huang.
Mol Cell, 2015 Sep 08; 59(6). PMID: 26344096
Highly Cited.
The E3 ubiquitin ligases β-TrCP and FBXW7 cooperatively mediates GSK3-dependent Mcl-1 degradation induced by the Akt inhibitor API-1, resulting in apoptosis.
Hui Ren, Junghui Koo, +5 authors, Shi-Yong Sun.
Mol Cancer, 2013 Nov 23; 12. PMID: 24261825    Free PMC article.
Hippo Signaling Suppresses Cell Ploidy and Tumorigenesis through Skp2.
Shihao Zhang, Qinghua Chen, +21 authors, Dawang Zhou.
Cancer Cell, 2017 May 10; 31(5). PMID: 28486106    Free PMC article.
Highly Cited.
BRCAness revisited.
Christopher J Lord, Alan Ashworth.
Nat Rev Cancer, 2016 Jan 19; 16(2). PMID: 26775620
Highly Cited. Review.
Ubiquitination in disease pathogenesis and treatment.
Doris Popovic, Domagoj Vucic, Ivan Dikic.
Nat Med, 2014 Nov 07; 20(11). PMID: 25375928
Highly Cited. Review.
Comprehensive genomic characterization of squamous cell lung cancers.
Cancer Genome Atlas Research Network.
Nature, 2012 Sep 11; 489(7417). PMID: 22960745    Free PMC article.
Highly Cited.
Differences in the regulation of K-Ras and H-Ras isoforms by monoubiquitination.
Rachael Baker, Emily M Wilkerson, +4 authors, Sharon L Campbell.
J Biol Chem, 2013 Nov 20; 288(52). PMID: 24247240    Free PMC article.
The basal-like mammary carcinomas induced by Brca1 or Bard1 inactivation implicate the BRCA1/BARD1 heterodimer in tumor suppression.
Reena Shakya, Matthias Szabolcs, +6 authors, Thomas Ludwig.
Proc Natl Acad Sci U S A, 2008 Apr 30; 105(19). PMID: 18443292    Free PMC article.
FBW7 mutations mediate resistance of colorectal cancer to targeted therapies by blocking Mcl-1 degradation.
J Tong, S Tan, +2 authors, L Zhang.
Oncogene, 2016 Jul 12; 36(6). PMID: 27399335    Free PMC article.
Highly Cited.
Overexpression of Mdm2 in mice reveals a p53-independent role for Mdm2 in tumorigenesis.
S N Jones, A R Hancock, +2 authors, A Bradley.
Proc Natl Acad Sci U S A, 1998 Dec 23; 95(26). PMID: 9861017    Free PMC article.
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Genomic and Functional Analysis of the E3 Ligase PARK2 in Glioma.
De-Chen Lin, Liang Xu, +11 authors, H Phillip Koeffler.
Cancer Res, 2015 Apr 17; 75(9). PMID: 25877876    Free PMC article.
The Keap1-BTB protein is an adaptor that bridges Nrf2 to a Cul3-based E3 ligase: oxidative stress sensing by a Cul3-Keap1 ligase.
Sara B Cullinan, John D Gordan, +2 authors, J Alan Diehl.
Mol Cell Biol, 2004 Sep 16; 24(19). PMID: 15367669    Free PMC article.
Highly Cited.
Phosphorylation-dependent regulation of cytosolic localization and oncogenic function of Skp2 by Akt/PKB.
Hui-Kuan Lin, Guocan Wang, +9 authors, Pier Paolo Pandolfi.
Nat Cell Biol, 2009 Mar 10; 11(4). PMID: 19270694    Free PMC article.
Highly Cited.
SKP2 cooperates with N-Ras or AKT to induce liver tumor development in mice.
Salvatore Delogu, Chunmei Wang, +11 authors, Diego F Calvisi.
Oncotarget, 2014 Dec 30; 6(4). PMID: 25537506    Free PMC article.
Nuclear accumulation of seven in absentia homologue-2 supports motility and proliferation of liver cancer cells.
Mona Malz, Antje Aulmann, +5 authors, Kai Breuhahn.
Int J Cancer, 2012 Feb 11; 131(9). PMID: 22323152
SPOP regulates prostate epithelial cell proliferation and promotes ubiquitination and turnover of c-MYC oncoprotein.
C Geng, S Kaochar, +14 authors, N Mitsiades.
Oncogene, 2017 Apr 18; 36(33). PMID: 28414305    Free PMC article.
Exploring the TRAILs less travelled: TRAIL in cancer biology and therapy.
Silvia von Karstedt, Antonella Montinaro, Henning Walczak.
Nat Rev Cancer, 2017 May 26; 17(6). PMID: 28536452
Highly Cited. Review.
The F-box protein Skp2 participates in c-Myc proteosomal degradation and acts as a cofactor for c-Myc-regulated transcription.
Natalie von der Lehr, Sara Johansson, +10 authors, Lars-Gunnar Larsson.
Mol Cell, 2003 May 29; 11(5). PMID: 12769844
Highly Cited.
Tumor cell-specific inhibition of MYC function using small molecule inhibitors of the HUWE1 ubiquitin ligase.
Stefanie Peter, Jennyfer Bultinck, +14 authors, Martin Eilers.
EMBO Mol Med, 2014 Sep 26; 6(12). PMID: 25253726    Free PMC article.
Mutual regulation between SIAH2 and DYRK2 controls hypoxic and genotoxic signaling pathways.
Moisés Pérez, Carmen García-Limones, +4 authors, Marco A Calzado.
J Mol Cell Biol, 2012 Aug 11; 4(5). PMID: 22878263
BRCA1 RING function is essential for tumor suppression but dispensable for therapy resistance.
Rinske Drost, Peter Bouwman, +13 authors, Jos Jonkers.
Cancer Cell, 2011 Dec 17; 20(6). PMID: 22172724
Highly Cited.
SEL-10/Fbw7-dependent negative feedback regulation of LIN-45/Braf signaling in C. elegans via a conserved phosphodegron.
Claire de la Cova, Iva Greenwald.
Genes Dev, 2012 Nov 17; 26(22). PMID: 23154983    Free PMC article.
Regulation of the Hedgehog and Wingless signalling pathways by the F-box/WD40-repeat protein Slimb.
J Jiang, G Struhl.
Nature, 1998 Feb 14; 391(6666). PMID: 9461217
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The ubiquitin ligase HectH9 regulates transcriptional activation by Myc and is essential for tumor cell proliferation.
Sovana Adhikary, Federica Marinoni, +11 authors, Martin Eilers.
Cell, 2005 Nov 05; 123(3). PMID: 16269333
Highly Cited.
Evidence that mitotic exit is a better cancer therapeutic target than spindle assembly.
Hsiao-Chun Huang, Jue Shi, James D Orth, Timothy J Mitchison.
Cancer Cell, 2009 Oct 06; 16(4). PMID: 19800579    Free PMC article.
Highly Cited.
The Skp2-SCF E3 ligase regulates Akt ubiquitination, glycolysis, herceptin sensitivity, and tumorigenesis.
Chia-Hsin Chan, Chien-Feng Li, +14 authors, Hui-Kuan Lin.
Cell, 2012 May 29; 149(5). PMID: 22632973    Free PMC article.
Highly Cited.
PARK2 Depletion Connects Energy and Oxidative Stress to PI3K/Akt Activation via PTEN S-Nitrosylation.
Amit Gupta, Sara Anjomani-Virmouni, +12 authors, George Poulogiannis.
Mol Cell, 2017 Mar 18; 65(6). PMID: 28306514    Free PMC article.
Highly Cited.
A mechanism for the suppression of homologous recombination in G1 cells.
Alexandre Orthwein, Sylvie M Noordermeer, +10 authors, Daniel Durocher.
Nature, 2015 Dec 10; 528(7582). PMID: 26649820    Free PMC article.
Highly Cited.
Regulation of DNA double-strand break repair by ubiquitin and ubiquitin-like modifiers.
Petra Schwertman, Simon Bekker-Jensen, Niels Mailand.
Nat Rev Mol Cell Biol, 2016 May 24; 17(6). PMID: 27211488
Highly Cited. Review.
Increased proteasome-dependent degradation of the cyclin-dependent kinase inhibitor p27 in aggressive colorectal carcinomas.
M Loda, B Cukor, +5 authors, M Pagano.
Nat Med, 1997 Feb 01; 3(2). PMID: 9018245
Highly Cited.
Ubiquitin-binding proteins: decoders of ubiquitin-mediated cellular functions.
Koraljka Husnjak, Ivan Dikic.
Annu Rev Biochem, 2012 Apr 10; 81. PMID: 22482907
Highly Cited. Review.
The increasing complexity of the ubiquitin code.
Richard Yau, Michael Rape.
Nat Cell Biol, 2016 May 28; 18(6). PMID: 27230526
Highly Cited. Review.
SCF ubiquitin ligase-targeted therapies.
Jeffrey R Skaar, Julia K Pagan, Michele Pagano.
Nat Rev Drug Discov, 2014 Nov 15; 13(12). PMID: 25394868    Free PMC article.
Highly Cited. Review.
VHL, the story of a tumour suppressor gene.
Lucy Gossage, Tim Eisen, Eamonn R Maher.
Nat Rev Cancer, 2014 Dec 24; 15(1). PMID: 25533676
Highly Cited. Review.
Regulation of KEAP1 expression by promoter methylation in malignant gliomas and association with patient's outcome.
Lucia Anna Muscarella, Raffaela Barbano, +15 authors, Paola Parrella.
Epigenetics, 2010 Dec 22; 6(3). PMID: 21173573    Free PMC article.
Destruction of full-length androgen receptor by wild-type SPOP, but not prostate-cancer-associated mutants.
Jian An, Chenji Wang, +2 authors, Haojie Huang.
Cell Rep, 2014 Feb 11; 6(4). PMID: 24508459    Free PMC article.
Highly Cited.
Mule/Huwe1/Arf-BP1 suppresses Ras-driven tumorigenesis by preventing c-Myc/Miz1-mediated down-regulation of p21 and p15.
Satoshi Inoue, Zhenyue Hao, +21 authors, Tak W Mak.
Genes Dev, 2013 May 24; 27(10). PMID: 23699408    Free PMC article.
Multiple genetic changes are associated with mammary tumorigenesis in Brca1 conditional knockout mice.
S G Brodie, X Xu, +3 authors, C X Deng.
Oncogene, 2001 Dec 26; 20(51). PMID: 11709723
Pan-cancer genetic analysis identifies PARK2 as a master regulator of G1/S cyclins.
Yongxing Gong, Travis Ian Zack, +12 authors, Timothy A Chan.
Nat Genet, 2014 May 06; 46(6). PMID: 24793136    Free PMC article.
Highly Cited.
Skp2 targeting suppresses tumorigenesis by Arf-p53-independent cellular senescence.
Hui-Kuan Lin, Zhenbang Chen, +11 authors, Pier Paolo Pandolfi.
Nature, 2010 Mar 20; 464(7287). PMID: 20237562    Free PMC article.
Highly Cited.
Phosphorylation by Akt1 promotes cytoplasmic localization of Skp2 and impairs APCCdh1-mediated Skp2 destruction.
Daming Gao, Hiroyuki Inuzuka, +3 authors, Wenyi Wei.
Nat Cell Biol, 2009 Mar 10; 11(4). PMID: 19270695    Free PMC article.
Highly Cited.
Cancer-predisposing mutations within the RING domain of BRCA1: loss of ubiquitin protein ligase activity and protection from radiation hypersensitivity.
H Ruffner, C A Joazeiro, +2 authors, I M Verma.
Proc Natl Acad Sci U S A, 2001 Apr 26; 98(9). PMID: 11320250    Free PMC article.
Highly Cited.
Targeting cancer with kinase inhibitors.
Stefan Gross, Rami Rahal, +2 authors, Klaus P Hoeflich.
J Clin Invest, 2015 May 02; 125(5). PMID: 25932675    Free PMC article.
Highly Cited. Review.
Deubiquitinases and cancer: A snapshot.
Nishant Singh, Anuradha Bharara Singh.
Crit Rev Oncol Hematol, 2016 May 24; 103. PMID: 27211605    Free PMC article.
Ablation of Fbxw7 eliminates leukemia-initiating cells by preventing quiescence.
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Cancer Cell, 2013 Mar 23; 23(3). PMID: 23518349
Highly Cited.
Screening for E3-ubiquitin ligase inhibitors: challenges and opportunities.
Vivien Landré, Barak Rotblat, +2 authors, Gerry Melino.
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S6 Kinase- and β-TrCP2-Dependent Degradation of p19Arf Is Required for Cell Proliferation.
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Mol Cell Biol, 2015 Aug 05; 35(20). PMID: 26240281    Free PMC article.
Degradation of Cdc25A by beta-TrCP during S phase and in response to DNA damage.
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Nature, 2003 Nov 07; 426(6962). PMID: 14603323
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Numerous proteins with unique characteristics are degraded by the 26S proteasome following monoubiquitination.
Ori Braten, Ido Livneh, +13 authors, Aaron Ciechanover.
Proc Natl Acad Sci U S A, 2016 Jul 08; 113(32). PMID: 27385826    Free PMC article.
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Role of KEAP1/NRF2 and TP53 Mutations in Lung Squamous Cell Carcinoma Development and Radiation Resistance.
Youngtae Jeong, Ngoc T Hoang, +17 authors, Maximilian Diehn.
Cancer Discov, 2016 Sep 25; 7(1). PMID: 27663899    Free PMC article.
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Ubiquitin-Dependent Regulation of the Mammalian Hippo Pathway: Therapeutic Implications for Cancer.
Thanh Hung Nguyen, Jan-Michael Kugler.
Cancers (Basel), 2018 Apr 21; 10(4). PMID: 29673168    Free PMC article.
Integrating the DNA damage and protein stress responses during cancer development and treatment.
Vassilis G Gorgoulis, Dafni-Eleftheria Pefani, Ioannis S Pateras, Ioannis P Trougakos.
J Pathol, 2018 May 15; 246(1). PMID: 29756349    Free PMC article.
Targeting the SET and RING-associated (SRA) domain of ubiquitin-like, PHD and ring finger-containing 1 (UHRF1) for anti-cancer drug development.
Debasis Patnaik, Pierre-Olivier Estève, Sriharsa Pradhan.
Oncotarget, 2018 Jun 15; 9(40). PMID: 29899856    Free PMC article.
Targeting the cell cycle in breast cancer: towards the next phase.
K L Thu, I Soria-Bretones, T W Mak, D W Cescon.
Cell Cycle, 2018 Aug 07; 17(15). PMID: 30078354    Free PMC article.
Decreased expression of TRIM21 indicates unfavorable outcome and promotes cell growth in breast cancer.
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Cancer Manag Res, 2018 Oct 06; 10. PMID: 30288100    Free PMC article.
Targeted Intracellular Delivery of Antibodies: The State of the Art.
Tatiana A Slastnikova, A V Ulasov, A A Rosenkranz, A S Sobolev.
Front Pharmacol, 2018 Nov 09; 9. PMID: 30405420    Free PMC article.
Estradiol promotes rapid degradation of HER3 in ER-positive breast cancer cell line MCF-7.
Junko Suga, Keiko Izumiyama, Nobuyuki Tanaka, Shigehira Saji.
Biochem Biophys Rep, 2018 Nov 13; 16. PMID: 30417127    Free PMC article.
A modular PROTAC design for target destruction using a degradation signal based on a single amino acid.
Karthigayan Shanmugasundaram, Peng Shao, +4 authors, Hai Rao.
J Biol Chem, 2019 Sep 13; 294(41). PMID: 31511327    Free PMC article.
Comparative analysis of the catalytic regulation of NEDD4-1 and WWP2 ubiquitin ligases.
Hanjie Jiang, Stefani N Thomas, +2 authors, Philip A Cole.
J Biol Chem, 2019 Oct 04; 294(46). PMID: 31578285    Free PMC article.
Injectable Hydrogels for Localized Cancer Therapy.
Dao-Yang Fan, Yun Tian, Zhong-Jun Liu.
Front Chem, 2019 Nov 05; 7. PMID: 31681729    Free PMC article.
Oncoviruses Can Drive Cancer by Rewiring Signaling Pathways Through Interface Mimicry.
Emine Guven-Maiorov, Chung-Jung Tsai, Ruth Nussinov.
Front Oncol, 2019 Dec 06; 9. PMID: 31803618    Free PMC article.
The ubiquitin system: orchestrating cellular signals in non-small-cell lung cancer.
Qiang Fan, Qian Wang, +2 authors, Ming Xu.
Cell Mol Biol Lett, 2020 Jan 29; 25. PMID: 31988639    Free PMC article.
High level of RNF187 contributes to the progression and drug resistance of osteosarcoma.
Wen-Bing Wan, Kai Wu, +7 authors, Qing-Ming Shi.
J Cancer, 2020 Feb 13; 11(6). PMID: 32047542    Free PMC article.
SIAH2-mediated and organ-specific restriction of HO-1 expression by a dual mechanism.
Shashipavan Chillappagari, Ratnal Belapurkar, +4 authors, M Lienhard Schmitz.
Sci Rep, 2020 Feb 12; 10(1). PMID: 32042051    Free PMC article.
RASSF1A Tumour Suppressor: Target the Network for Effective Cancer Therapy.
Lucía García-Gutiérrez, Stephanie McKenna, Walter Kolch, David Matallanas.
Cancers (Basel), 2020 Jan 23; 12(1). PMID: 31963420    Free PMC article.
Targeted destruction of cancer stem cells using multifunctional magnetic nanoparticles that enable combined hyperthermia and chemotherapy.
Dandan Liu, Yingcai Hong, +9 authors, Mengsu Yang.
Theranostics, 2020 Jan 16; 10(3). PMID: 31938059    Free PMC article.
A cell-based high-throughput screening method based on a ubiquitin-reference technique for identifying modulators of E3 ligases.
Maoyuan Tian, Taoling Zeng, +11 authors, Hong-Rui Wang.
J Biol Chem, 2018 Dec 28; 294(8). PMID: 30587574    Free PMC article.
MGMT-activated DUB3 stabilizes MCL1 and drives chemoresistance in ovarian cancer.
Xiaowei Wu, Qingyu Luo, +6 authors, Zhihua Liu.
Proc Natl Acad Sci U S A, 2019 Feb 06; 116(8). PMID: 30718431    Free PMC article.
Downregulation of RNF128 activates Wnt/β-catenin signaling to induce cellular EMT and stemness via CD44 and CTTN ubiquitination in melanoma.
Chuan-Yuan Wei, Meng-Xuan Zhu, +10 authors, Jian-Ying Gu.
J Hematol Oncol, 2019 Mar 06; 12(1). PMID: 30832692    Free PMC article.
Highly Cited.
Ubiquitin Ligases in Cancer Immunotherapy - Balancing Antitumor and Autoimmunity.
Yu Fujita, Roberto Tinoco, +2 authors, Ze'ev A Ronai.
Trends Mol Med, 2019 Mar 23; 25(5). PMID: 30898473    Free PMC article.
Vps11 and Vps18 of Vps-C membrane traffic complexes are E3 ubiquitin ligases and fine-tune signalling.
Gregory Segala, Marcela A Bennesch, +5 authors, Didier Picard.
Nat Commun, 2019 Apr 25; 10(1). PMID: 31015428    Free PMC article.
A Multidimensional Characterization of E3 Ubiquitin Ligase and Substrate Interaction Network.
Di Chen, Xiaolong Liu, +11 authors, Hai-Long Piao.
iScience, 2019 Jun 11; 16. PMID: 31181401    Free PMC article.
The deubiquitylase OTUD3 stabilizes GRP78 and promotes lung tumorigenesis.
Tongde Du, Hongchang Li, +11 authors, Lingqiang Zhang.
Nat Commun, 2019 Jul 04; 10(1). PMID: 31266968    Free PMC article.
Genetic interactions of G-quadruplexes in humans.
Katherine G Zyner, Darcie S Mulhearn, +6 authors, Shankar Balasubramanian.
Elife, 2019 Jul 10; 8. PMID: 31287417    Free PMC article.
A multi-lock inhibitory mechanism for fine-tuning enzyme activities of the HECT family E3 ligases.
Zhen Wang, Ziheng Liu, +7 authors, Wenyu Wen.
Nat Commun, 2019 Jul 20; 10(1). PMID: 31320636    Free PMC article.
Selective USP7 inhibition elicits cancer cell killing through a p53-dependent mechanism.
Nathan J Schauer, Xiaoxi Liu, +24 authors, Sara J Buhrlage.
Sci Rep, 2020 Mar 27; 10(1). PMID: 32210275    Free PMC article.
Emerging drug development technologies targeting ubiquitination for cancer therapeutics.
Gianluca Veggiani, María Carla Rosales Gerpe, Sachdev S Sidhu, Wei Zhang.
Pharmacol Ther, 2019 Mar 10; 199. PMID: 30851297    Free PMC article.
The Roles of Cyclin-Dependent Kinases in Cell-Cycle Progression and Therapeutic Strategies in Human Breast Cancer.
Lei Ding, Jiaqi Cao, +6 authors, Qinghua Cui.
Int J Mol Sci, 2020 Mar 19; 21(6). PMID: 32183020    Free PMC article.
The Emerging Roles of RNA Modifications in Glioblastoma.
Zhen Dong, Hongjuan Cui.
Cancers (Basel), 2020 Apr 05; 12(3). PMID: 32244981    Free PMC article.
The role of E3 ubiquitin ligase HECTD3 in cancer and beyond.
Qiuyun Jiang, Fubing Li, +2 authors, Ceshi Chen.
Cell Mol Life Sci, 2019 Oct 23; 77(8). PMID: 31637449
SMURF2 prevents detrimental changes to chromatin, protecting human dermal fibroblasts from chromosomal instability and tumorigenesis.
Dhanoop Manikoth Ayyathan, Praveen Koganti, +5 authors, Michael Blank.
Oncogene, 2020 Feb 28; 39(16). PMID: 32103168
Targeting USP7-Mediated Deubiquitination of MDM2/MDMX-p53 Pathway for Cancer Therapy: Are We There Yet?
Si-Min Qi, Gang Cheng, +4 authors, Jiang-Jiang Qin.
Front Cell Dev Biol, 2020 Apr 18; 8. PMID: 32300595    Free PMC article.
The E3 Ubiquitin Ligase TRIM21 Promotes HBV DNA Polymerase Degradation.
Ting Mu, Xiaoqing Zhao, +2 authors, Hua Tang.
Viruses, 2020 Apr 05; 12(3). PMID: 32245233    Free PMC article.
Loss of the deubiquitinase OTULIN promotes hepatocellular carcinoma (HCC) in an mTOR-dependent manner.
Antonio Marzio, Michele Pagano.
Cell Death Differ, 2020 Apr 01; 27(5). PMID: 32225171    Free PMC article.
Cereblon versus VHL: Hijacking E3 ligases against each other using PROTACs.
Miriam Girardini, Chiara Maniaci, +2 authors, Alessio Ciulli.
Bioorg Med Chem, 2019 Mar 04; 27(12). PMID: 30826187    Free PMC article.
Small molecules that target the ubiquitin system.
Hai Qiu Wu, David Baker, Huib Ovaa.
Biochem Soc Trans, 2020 Mar 21; 48(2). PMID: 32196552    Free PMC article.
The expression change of OTUD3-PTEN signaling axis in glioma cells.
Yi-Zhen Liu, Xi-Xun Du, +2 authors, Hong Jiang.
Ann Transl Med, 2020 May 13; 8(7). PMID: 32395534    Free PMC article.
The E3 Ubiquitin Ligase Cbl-b Predicts Favorable Prognosis in Breast Cancer.
Xiuming Liu, Yuee Teng, +5 authors, Lingyun Zhang.
Front Oncol, 2020 May 22; 10. PMID: 32435620    Free PMC article.
p53 modifications: exquisite decorations of the powerful guardian.
Yanqing Liu, Omid Tavana, Wei Gu.
J Mol Cell Biol, 2019 Jul 10; 11(7). PMID: 31282934    Free PMC article.
The deubiquitinase USP10 regulates KLF4 stability and suppresses lung tumorigenesis.
Xingyun Wang, Shilin Xia, +5 authors, Chuanchun Han.
Cell Death Differ, 2019 Nov 22; 27(6). PMID: 31748695    Free PMC article.
Deubiquitinating enzyme USP33 restrains docetaxel-induced apoptosis via stabilising the phosphatase DUSP1 in prostate cancer.
Fei Guo, Chao Zhang, +6 authors, Yinghao Sun.
Cell Death Differ, 2019 Dec 21; 27(6). PMID: 31857702    Free PMC article.
The role of ubiquitination in tumorigenesis and targeted drug discovery.
Lu Deng, Tong Meng, +2 authors, Ping Wang.
Signal Transduct Target Ther, 2020 Apr 17; 5(1). PMID: 32296023    Free PMC article.
F-Box Proteins and Cancer.
Kanae Yumimoto, Yuhei Yamauchi, Keiichi I Nakayama.
Cancers (Basel), 2020 May 21; 12(5). PMID: 32429232    Free PMC article.
Hakin-1, a New Specific Small-Molecule Inhibitor for the E3 Ubiquitin-Ligase Hakai, Inhibits Carcinoma Growth and Progression.
Olaia Martinez-Iglesias, Alba Casas-Pais, +6 authors, Angélica Figueroa.
Cancers (Basel), 2020 May 28; 12(5). PMID: 32456234    Free PMC article.
The N-terminal domain of the non-receptor tyrosine kinase ABL confers protein instability and suppresses tumorigenesis.
Zhengwei Yan, Karthigayan Shanmugasundaram, +3 authors, Hai Rao.
J Biol Chem, 2020 May 23; 295(27). PMID: 32439806    Free PMC article.
The Impact of the Ubiquitin System in the Pathogenesis of Squamous Cell Carcinomas.
Veronica Gatti, Francesca Bernassola, +2 authors, Angelo Peschiaroli.
Cancers (Basel), 2020 Jun 21; 12(6). PMID: 32560247    Free PMC article.
Ubiquitination and deubiquitination of MCL1 in cancer: deciphering chemoresistance mechanisms and providing potential therapeutic options.
Xiaowei Wu, Qingyu Luo, Zhihua Liu.
Cell Death Dis, 2020 Jul 24; 11(7). PMID: 32699213    Free PMC article.
Emerging role of FBXO22 in carcinogenesis.
Jiangting Cheng, Min Lin, +3 authors, Yongchao Zhao.
Cell Death Discov, 2020 Aug 15; 6. PMID: 32793396    Free PMC article.
Pathogenic impact of transcript isoform switching in 1,209 cancer samples covering 27 cancer types using an isoform-specific interaction network.
Abdullah Kahraman, Tülay Karakulak, Damian Szklarczyk, Christian von Mering.
Sci Rep, 2020 Sep 04; 10(1). PMID: 32879328    Free PMC article.
Literature Review of BARD1 as a Cancer Predisposing Gene with a Focus on Breast and Ovarian Cancers.
Wejdan M Alenezi, Caitlin T Fierheller, Neil Recio, Patricia N Tonin.
Genes (Basel), 2020 Jul 31; 11(8). PMID: 32726901    Free PMC article.
Expression levels of MRP1, GST-π, and GSK3β in ovarian cancer and the relationship with drug resistance and prognosis of patients.
Xiaojing Tong, Jiao Zhao, +2 authors, Xiaobin Wang.
Oncol Lett, 2019 Jul 11; 18(1). PMID: 31289467    Free PMC article.
Stem Cell Plasticity and Dormancy in the Development of Cancer Therapy Resistance.
Maria Laura De Angelis, Federica Francescangeli, Filippo La Torre, Ann Zeuner.
Front Oncol, 2019 Jul 30; 9. PMID: 31355143    Free PMC article.
Highly Cited. Review.
Targeting E3 Ubiquitin Ligases and Deubiquitinases in Ciliopathy and Cancer.
Takashi Shiromizu, Mizuki Yuge, +5 authors, Yuhei Nishimura.
Int J Mol Sci, 2020 Aug 23; 21(17). PMID: 32825105    Free PMC article.
The Effect of Dysfunctional Ubiquitin Enzymes in the Pathogenesis of Most Common Diseases.
Gizem Celebi, Hale Kesim, Ebru Ozer, Ozlem Kutlu.
Int J Mol Sci, 2020 Sep 05; 21(17). PMID: 32882786    Free PMC article.
m6A modification in RNA: biogenesis, functions and roles in gliomas.
Yuhao Zhang, Xiuchao Geng, +7 authors, Hong Wang.
J Exp Clin Cancer Res, 2020 Sep 19; 39(1). PMID: 32943100    Free PMC article.
Structure and Function of HECT E3 Ubiquitin Ligases and their Role in Oxidative Stress.
Hao Qian, Ying Zhang, +4 authors, Yingxian Sun.
J Transl Int Med, 2020 Sep 29; 8(2). PMID: 32983929    Free PMC article.
The dynamics of linear polyubiquitin.
Alexander Jussupow, Ana C Messias, +6 authors, Carlo Camilloni.
Sci Adv, 2020 Oct 16; 6(42). PMID: 33055165    Free PMC article.
RNF128 Promotes Malignant Behaviors via EGFR/MEK/ERK Pathway in Hepatocellular Carcinoma.
Xue-Song Bai, Chi Zhang, +5 authors, Dou-Sheng Bai.
Onco Targets Ther, 2020 Oct 30; 13. PMID: 33116595    Free PMC article.
The Roles of Histone Deacetylases and Their Inhibitors in Cancer Therapy.
Guo Li, Yuan Tian, Wei-Guo Zhu.
Front Cell Dev Biol, 2020 Oct 30; 8. PMID: 33117804    Free PMC article.
Cancer and pH Dynamics: Transcriptional Regulation, Proteostasis, and the Need for New Molecular Tools.
Brandon J Czowski, Ricardo Romero-Moreno, Keelan J Trull, Katharine A White.
Cancers (Basel), 2020 Oct 01; 12(10). PMID: 32992762    Free PMC article.
Ubiquitomics: An Overview and Future.
George Vere, Rachel Kealy, Benedikt M Kessler, Adan Pinto-Fernandez.
Biomolecules, 2020 Oct 22; 10(10). PMID: 33080838    Free PMC article.
Ubiquitin-proteasome system (UPS) as a target for anticancer treatment.
Jinyoung Park, Jinhong Cho, Eun Joo Song.
Arch Pharm Res, 2020 Nov 10; 43(11). PMID: 33165832    Free PMC article.
UCHL3 promotes proliferation of colorectal cancer cells by regulating SOX12 via AKT/mTOR signaling pathway.
Jiangning Li, Yang Zheng, +4 authors, Chong Zhang.
Am J Transl Res, 2020 Nov 17; 12(10). PMID: 33194042    Free PMC article.
Long noncoding RNA ASB16-AS1 inhibits adrenocortical carcinoma cell growth by promoting ubiquitination of RNA-binding protein HuR.
Bo Long, Xufei Yang, +4 authors, Shuyang Zhang.
Cell Death Dis, 2020 Nov 22; 11(11). PMID: 33219221    Free PMC article.
Regulation of Epithelial-Mesenchymal Plasticity by the E3 Ubiquitin-Ligases in Cancer.
Andrea Rodríguez-Alonso, Alba Casas-Pais, +3 authors, Angélica Figueroa.
Cancers (Basel), 2020 Oct 30; 12(11). PMID: 33114139    Free PMC article.
RNF126 Quenches RNF168 Function in the DNA Damage Response.
Lianzhong Zhang, Zhenzhen Wang, +4 authors, Xingzhi Xu.
Genomics Proteomics Bioinformatics, 2018 Dec 12; 16(6). PMID: 30529286    Free PMC article.
Overexpression of RNF38 facilitates TGF-β signaling by Ubiquitinating and degrading AHNAK in hepatocellular carcinoma.
Rui Peng, Peng-Fei Zhang, +11 authors, Jia Fan.
J Exp Clin Cancer Res, 2019 Mar 07; 38(1). PMID: 30836988    Free PMC article.
Spatial UBE2N protein expression indicates genomic instability in colorectal cancers.
Timo Gemoll, Elena Miroll, +4 authors, Jens K Habermann.
BMC Cancer, 2019 Jul 20; 19(1). PMID: 31319803    Free PMC article.
E3 Ubiquitin Ligase APC/CCdh1 Regulation of Phenylalanine Hydroxylase Stability and Function.
Apoorvi Tyagi, Neha Sarodaya, +6 authors, Suresh Ramakrishna.
Int J Mol Sci, 2020 Dec 03; 21(23). PMID: 33260674    Free PMC article.
Tumor derived UBR5 promotes ovarian cancer growth and metastasis through inducing immunosuppressive macrophages.
Mei Song, Oladapo O Yeku, +12 authors, Xiaojing Ma.
Nat Commun, 2020 Dec 10; 11(1). PMID: 33293516    Free PMC article.
GNA13 regulates BCL2 expression and the sensitivity of GCB-DLBCL cells to BCL2 inhibitors in a palmitoylation-dependent manner.
Zhizhou Xia, Xiuli Zhang, +11 authors, Ruibao Ren.
Cell Death Dis, 2021 Jan 11; 12(1). PMID: 33423045    Free PMC article.
Targeting ubiquitin signaling for cancer immunotherapy.
Xiaofei Zhou, Shao-Cong Sun.
Signal Transduct Target Ther, 2021 Jan 14; 6(1). PMID: 33436547    Free PMC article.
Blockade of deubiquitinating enzyme PSMD14 overcomes chemoresistance in head and neck squamous cell carcinoma by antagonizing E2F1/Akt/SOX2-mediated stemness.
Chao Jing, Yuansheng Duan, +12 authors, Xudong Wang.
Theranostics, 2021 Jan 19; 11(6). PMID: 33456565    Free PMC article.
Suppressing BCL-XL increased the high dose androgens therapeutic effect to better induce the Enzalutamide-resistant prostate cancer autophagic cell death.
Zhendong Xiang, Yin Sun, +6 authors, Chawnshang Chang.
Cell Death Dis, 2021 Jan 13; 12(1). PMID: 33431795    Free PMC article.
E3 Ubiquitin Ligases: Key Regulators of TGFβ Signaling in Cancer Progression.
Abhishek Sinha, Prasanna Vasudevan Iyengar, Peter Ten Dijke.
Int J Mol Sci, 2021 Jan 10; 22(2). PMID: 33418880    Free PMC article.
Promoterless Transposon Mutagenesis Drives Solid Cancers via Tumor Suppressor Inactivation.
Aziz Aiderus, Ana M Contreras-Sandoval, +7 authors, Michael B Mann.
Cancers (Basel), 2021 Jan 14; 13(2). PMID: 33435458    Free PMC article.
The Giant HECT E3 Ubiquitin Ligase HERC1 Is Aberrantly Expressed in Myeloid Related Disorders and It Is a Novel BCR-ABL1 Binding Partner.
Muhammad Shahzad Ali, Cristina Panuzzo, +6 authors, Enrico Bracco.
Cancers (Basel), 2021 Jan 23; 13(2). PMID: 33477751    Free PMC article.
The SUMO pathway in pancreatic cancer: insights and inhibition.
Christian Schneeweis, Zonera Hassan, +2 authors, Günter Schneider.
Br J Cancer, 2020 Oct 20; 124(3). PMID: 33071285    Free PMC article.

;. PMID: 33558509
UBE2O targets Mxi1 for ubiquitination and degradation to promote lung cancer progression and radioresistance.
Yumei Huang, Xijie Yang, +6 authors, Gang Wu.
Cell Death Differ, 2020 Sep 10; 28(2). PMID: 32901121    Free PMC article.
mRNAs, proteins and the emerging principles of gene expression control.
Christopher Buccitelli, Matthias Selbach.
Nat Rev Genet, 2020 Jul 28; 21(10). PMID: 32709985
Ring finger protein 152-dependent degradation of TSPAN12 suppresses hepatocellular carcinoma progression.
Jian Wan, Shunfang Liu, +5 authors, Bin Liu.
Cancer Cell Int, 2021 Feb 20; 21(1). PMID: 33602225    Free PMC article.
Antiproliferative Activity and Potential Mechanism of Marine-Sourced Streptoglutarimide H against Lung Cancer Cells.
Hengju Ge, Di Zhang, +2 authors, Zhizhen Zhang.
Mar Drugs, 2021 Feb 13; 19(2). PMID: 33572615    Free PMC article.
Ubiquitination of Nonhistone Proteins in Cancer Development and Treatment.
Xiuzhen Zhang, Tong Meng, +4 authors, Ping Wang.
Front Oncol, 2021 Mar 02; 10. PMID: 33643919    Free PMC article.
Reduced chromatin binding of MYC is a key effect of HDAC inhibition in MYC amplified medulloblastoma.
Jonas Ecker, Venu Thatikonda, +21 authors, Till Milde.
Neuro Oncol, 2020 Aug 22; 23(2). PMID: 32822486    Free PMC article.
β-Trcp and CK1δ-mediated degradation of LZTS2 activates PI3K/AKT signaling to drive tumorigenesis and metastasis in hepatocellular carcinoma.
Yanwei Lu, Xudong Li, +7 authors, Shuangbing Xu.
Oncogene, 2021 Jan 10; 40(7). PMID: 33420362    Free PMC article.
Mechanistic basis for ubiquitin modulation of a protein energy landscape.
Emma C Carroll, Naomi R Latorraca, +3 authors, Susan Marqusee.
Proc Natl Acad Sci U S A, 2021 Mar 17; 118(12). PMID: 33723075    Free PMC article.
Skp2 and Slug Are Coexpressed in Aggressive Prostate Cancer and Inhibited by Neddylation Blockade.
Alena Mickova, Gvantsa Kharaishvili, +7 authors, Jan Bouchal.
Int J Mol Sci, 2021 Apr 04; 22(6). PMID: 33799604    Free PMC article.
OTUD1 Activates Caspase-Independent and Caspase-Dependent Apoptosis by Promoting AIF Nuclear Translocation and MCL1 Degradation.
Qingyu Luo, Xiaowei Wu, +5 authors, Zhihua Liu.
Adv Sci (Weinh), 2021 Apr 27; 8(8). PMID: 33898171    Free PMC article.
Regulation of eIF2α by RNF4 Promotes Melanoma Tumorigenesis and Therapy Resistance.
Emily Avitan-Hersh, Yongmei Feng, +13 authors, Amir Orian.
J Invest Dermatol, 2020 May 04; 140(12). PMID: 32360601    Free PMC article.
E3 Ubiquitin Ligase in Anticancer Drugdsla Resistance: Recent Advances and Future Potential.
Yuanqi Liu, Chaojun Duan, Chunfang Zhang.
Front Pharmacol, 2021 May 04; 12. PMID: 33935743    Free PMC article.
ROC1 promotes the malignant progression of bladder cancer by regulating p-IκBα/NF-κB signaling.
Qi Wu, Xiaoqing Zhou, +9 authors, Jianxin Qiu.
J Exp Clin Cancer Res, 2021 May 09; 40(1). PMID: 33962660    Free PMC article.
Ubiquitin-proteasome system and the role of its inhibitors in cancer therapy.
Fatemeh Aliabadi, Beheshteh Sohrabi, +2 authors, Thomas J Webster.
Open Biol, 2021 Apr 29; 11(4). PMID: 33906413    Free PMC article.
Ubiquitination, Biotech Startups, and the Future of TRIM Family Proteins: A TRIM-Endous Opportunity.
Utsa Bhaduri, Giuseppe Merla.
Cells, 2021 May 01; 10(5). PMID: 33923045    Free PMC article.
The Carcinogen Cadmium Activates Lysine 63 (K63)-Linked Ubiquitin-Dependent Signaling and Inhibits Selective Autophagy.
Abderrahman Chargui, Amine Belaid, +9 authors, Baharia Mograbi.
Cancers (Basel), 2021 Jun 03; 13(10). PMID: 34065348    Free PMC article.
The Ubiquitin Proteasome System in Genome Stability and Cancer.
Jonathan J Morgan, Lisa J Crawford.
Cancers (Basel), 2021 Jun 03; 13(9). PMID: 34066546    Free PMC article.
Regulation of ERα Stability and Estrogen Signaling in Breast Cancer by HOIL-1.
Jianing Ding, Peng Kuang.
Front Oncol, 2021 Jun 08; 11. PMID: 34094957    Free PMC article.
Ubiquitin-related molecular classification and risk stratification of hepatocellular carcinoma.
Si Yang, Bowen Yao, +11 authors, Zhijun Dai.
Mol Ther Oncolytics, 2021 Jun 08; 21. PMID: 34095460    Free PMC article.
FBXO32 links ubiquitination to epigenetic reprograming of melanoma cells.
Nadia Habel, Najla El-Hachem, +11 authors, Robert Ballotti.
Cell Death Differ, 2021 Jan 20; 28(6). PMID: 33462405    Free PMC article.