. 2018 Feb; 2017:5458178.
doi: 10.1155/2017/5458178.

Phenotypic and Functional Properties of Tumor-Infiltrating Regulatory T Cells

Gap Ryol Lee 1 
  • PMID: 29463952
  •     103 References
  •     11 citations


Regulatory T (Treg) cells maintain immune homeostasis by suppressing excessive immune responses. Treg cells induce tolerance against self- and foreign antigens, thus preventing autoimmunity, allergy, graft rejection, and fetus rejection during pregnancy. However, Treg cells also infiltrate into tumors and inhibit antitumor immune responses, thus inhibiting anticancer therapy. Depleting whole Treg cell populations in the body to enhance anticancer treatments will produce deleterious autoimmune diseases. Therefore, understanding the precise nature of tumor-infiltrating Treg cells is essential for effectively targeting Treg cells in tumors. This review summarizes recent results relating to Treg cells in the tumor microenvironment, with particular emphasis on their accumulation, phenotypic, and functional properties, and targeting to enhance the efficacy of anticancer treatment.

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Filippo Galli, Jesus Vera Aguilera, +3 authors, Alberto Signore.
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Marta Gascón, Dolores Isla, +10 authors, Luis Martínez-Lostao.
Cells, 2020 Jun 26; 9(6). PMID: 32580514    Free PMC article.
Analysis and Augmentation of the Immunologic Bystander Effects of CAR T Cell Therapy in a Syngeneic Mouse Cancer Model.
Astero Klampatsa, Michael S Leibowitz, +3 authors, Steven M Albelda.
Mol Ther Oncolytics, 2020 Aug 18; 18. PMID: 32802940    Free PMC article.
Prognostic value of tumor-infiltrating lymphocytes in melanoma: a systematic review and meta-analysis.
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Oncoimmunology, 2019 May 31; 8(7). PMID: 31143514    Free PMC article.
Highly Cited. Review.
Significance of Tumor Mutation Burden in Immune Infiltration and Prognosis in Cutaneous Melanoma.
Kai Kang, Fucun Xie, +2 authors, Xiang Wang.
Front Oncol, 2020 Oct 20; 10. PMID: 33072607    Free PMC article.
Research advances of secretory proteins in malignant tumors.
Na Zhang, Jiajie Hao, Yan Cai, Mingrong Wang.
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A Novel CAR Expressing NK Cell Targeting CD25 With the Prospect of Overcoming Immune Escape Mechanism in Cancers.
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Regulatory T Cells: Barriers of Immune Infiltration Into the Tumor Microenvironment.
Ellen N Scott, Angela M Gocher, Creg J Workman, Dario A A Vignali.
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