Antibodies to Interleukin-2 Elicit Selective T Cell Subset Potentiation through Distinct Conformational Mechanisms. Jamie B Spangler, Jakub Tomala, +7 authors, Vincent C Luca, Kevin M Jude, Shen Dong, Aaron M Ring, Petra Votavova, Marion Pepper, Marek Kovar, K Christopher Garcia. less Immunity, 2015 May 21; 42(5). PMID: 25992858 Free PMC article. Highly Cited.
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IL-2 therapy promotes suppressive ICOS+ Treg expansion in melanoma patients. Geok Choo Sim, Natalia Martin-Orozco, +9 authors, Lei Jin, Yan Yang, Sheng Wu, Edwina Washington, Deborah Sanders, Carol Lacey, Yijun Wang, Luis Vence, Patrick Hwu, Laszlo Radvanyi. less J Clin Invest, 2013 Dec 03; 124(1). PMID: 24292706 Free PMC article. Highly Cited.
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Regulatory T cells control toxicity in a humanized model of IL-2 therapy. Yan Li, Helene Strick-Marchand, +8 authors, Ai Ing Lim, Jiazi Ren, Guillemette Masse-Ranson, Dan Li, Gregory Jouvion, Lars Rogge, Sophie Lucas, Bin Li, James P Di Santo. less Nat Commun, 2017 Nov 28; 8(1). PMID: 29176694 Free PMC article.
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IL-2: the first effective immunotherapy for human cancer. Steven A Rosenberg. J Immunol, 2014 Jun 08; 192(12). PMID: 24907378 Free PMC article. Highly Cited. Review.
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Exploiting a natural conformational switch to engineer an interleukin-2 'superkine'. Aron M Levin, Darren L Bates, +11 authors, Aaron M Ring, Carsten Krieg, Jack T Lin, Leon Su, Ignacio Moraga, Miro E Raeber, Gregory R Bowman, Paul Novick, Vijay S Pande, C Garrison Fathman, Onur Boyman, K Christopher Garcia. less Nature, 2012 Mar 27; 484(7395). PMID: 22446627 Free PMC article. Highly Cited.
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Fc-dependent depletion of tumor-infiltrating regulatory T cells co-defines the efficacy of anti-CTLA-4 therapy against melanoma. Tyler R Simpson, Fubin Li, +11 authors, Welby Montalvo-Ortiz, Manuel A Sepulveda, Katharina Bergerhoff, Frederick Arce, Claire Roddie, Jake Y Henry, Hideo Yagita, Jedd D Wolchok, Karl S Peggs, Jeffrey V Ravetch, James P Allison, Sergio A Quezada. less J Exp Med, 2013 Jul 31; 210(9). PMID: 23897981 Free PMC article. Highly Cited.
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Regulatory T cells in cancer immunotherapy. Atsushi Tanaka, Shimon Sakaguchi. Cell Res, 2016 Dec 21; 27(1). PMID: 27995907 Free PMC article. Highly Cited. Review.
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