Journal Article
. 2018 Mar; 9(2):818-831.
doi: 10.1364/BOE.9.000818.

Detecting brain tumor in pathological slides using hyperspectral imaging

Samuel Ortega 1 Himar Fabelo 1 Rafael Camacho 2 María de la Luz Plaza 2 Gustavo M Callicó 1 Roberto Sarmiento 1 
Affiliations
  • PMID: 29552415
  •     17 References
  •     17 citations

Abstract

Hyperspectral imaging (HSI) is an emerging technology for medical diagnosis. This research work presents a proof-of-concept on the use of HSI data to automatically detect human brain tumor tissue in pathological slides. The samples, consisting of hyperspectral cubes collected from 400 nm to 1000 nm, were acquired from ten different patients diagnosed with high-grade glioma. Based on the diagnosis provided by pathologists, a spectral library of normal and tumor tissues was created and processed using three different supervised classification algorithms. Results prove that HSI is a suitable technique to automatically detect high-grade tumors from pathological slides.

Keywords: (110.4234) Multispectral and hyperspectral imaging; (170.0170) Medical optics and biotechnology; (170.4730) Optical pathology; (170.6510) Spectroscopy, tissue diagnostics; (170.6935) Tissue characterization.

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