Nivolumab plus Ipilimumab in Lung Cancer with a High Tumor Mutational Burden

Matthew D Hellmann ¹, Tudor-Eliade Ciuleanu ¹, Adam Pluzanski ¹, Jong Seok Lee ¹, Gregory A Otterson ¹, Clarisse Audigier-Valette ¹, Elisa Minenza ¹, Helena Linardou ¹, Sjaak Burgers ¹, Pamela Salman ¹, Hossein Borghaei ¹, Suresh S Ramalingam ¹, Julie Brahmer ¹, Martin Reck ¹, Kenneth J O'Byrne ¹, William J Geese ¹, George Green ¹, Han Chang ¹, Joseph Szustakowski ¹, Prabhu Bhagavatheeswaran ¹, Diane Healey ¹, Yali Fu ¹, Faith Nathan ¹, Luis Paz-Ares ¹

Affiliations

¹ From Memorial Sloan Kettering Cancer Center Hospital, New York (M.D.H.); Prof. Dr. Ion Chiricuta Institute of Oncology and Universitatea de Medicina si Farmacie Iuliu Hatieganu, Cluj-Napoca, Romania (T.-E.C.); Centrum Onkologii-Instytut im. Marii Sklodowskiej-Curie, Warsaw, Poland (A.P.); Seoul National University Bundang Hospital, Seoul, South Korea (J.S.L.); Ohio State University, Columbus (G.A.O.); Hôpital Sainte Musse, Toulon, France (C.A.-V.); Ospedale Santa Maria della Misericordia, Perugia, Italy (E.M.); First Department of Oncology, Metropolitan Hospital, Athens, Greece (H.L.); Antoni van Leeuwenhoek Ziekenhuis, Amsterdam (S.B.); Fundación Arturo López Pérez, Santiago, Chile (P.S.); Fox Chase Cancer Center, Philadelphia (H.B.); Winship Cancer Institute, Emory University, Atlanta (S.S.R.); Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore (J.B.); LungenClinic Grosshansdorf, Airway Research Center North, German Center for Lung Research, Grosshansdorf, Germany (M.R.); Princess Alexandra Hospital, Brisbane, QLD, Australia (K.J.O.); Bristol-Myers Squibb, Princeton, NJ (W.J.G., G.G., H.C., J.S., P.B., D.H., Y.F., F.N.); and Hospital Universitario 12 de Octubre, Centro Nacional de Investigaciones Oncológicas, Universidad Complutense, and CiberOnc, Madrid (L.P.-A.).

PMID: 29658845
19 References
1085 citations

Abstract

Background: Nivolumab plus ipilimumab showed promising efficacy for the treatment of non-small-cell lung cancer (NSCLC) in a phase 1 trial, and tumor mutational burden has emerged as a potential biomarker of benefit. In this part of an open-label, multipart, phase 3 trial, we examined progression-free survival with nivolumab plus ipilimumab versus chemotherapy among patients with a high tumor mutational burden (≥10 mutations per megabase).

Methods: We enrolled patients with stage IV or recurrent NSCLC that was not previously treated with chemotherapy. Those with a level of tumor programmed death ligand 1 (PD-L1) expression of at least 1% were randomly assigned, in a 1:1:1 ratio, to receive nivolumab plus ipilimumab, nivolumab monotherapy, or chemotherapy; those with a tumor PD-L1 expression level of less than 1% were randomly assigned, in a 1:1:1 ratio, to receive nivolumab plus ipilimumab, nivolumab plus chemotherapy, or chemotherapy. Tumor mutational burden was determined by the FoundationOne CDx assay.

Results: Progression-free survival among patients with a high tumor mutational burden was significantly longer with nivolumab plus ipilimumab than with chemotherapy. The 1-year progression-free survival rate was 42.6% with nivolumab plus ipilimumab versus 13.2% with chemotherapy, and the median progression-free survival was 7.2 months (95% confidence interval [CI], 5.5 to 13.2) versus 5.5 months (95% CI, 4.4 to 5.8) (hazard ratio for disease progression or death, 0.58; 97.5% CI, 0.41 to 0.81; P<0.001). The objective response rate was 45.3% with nivolumab plus ipilimumab and 26.9% with chemotherapy. The benefit of nivolumab plus ipilimumab over chemotherapy was broadly consistent within subgroups, including patients with a PD-L1 expression level of at least 1% and those with a level of less than 1%. The rate of grade 3 or 4 treatment-related adverse events was 31.2% with nivolumab plus ipilimumab and 36.1% with chemotherapy. ical; CheckMate 227 ClinicalTrials.gov number, NCT02477826 .).

Conclusions: Progression-free survival was significantly longer with first-line nivolumab plus ipilimumab than with chemotherapy among patients with NSCLC and a high tumor mutational burden, irrespective of PD-L1 expression level. The results validate the benefit of nivolumab plus ipilimumab in NSCLC and the role of tumor mutational burden as a biomarker for patient selection. (Funded by Bristol-Myers Squibb and Ono Pharmaceut

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Nivolumab Alone and With Ipilimumab in Previously Treated Metastatic Urothelial Carcinoma: CheckMate 032 Nivolumab 1 mg/kg Plus Ipilimumab 3 mg/kg Expansion Cohort Results. Padmanee Sharma, Arlene Siefker-Radtke, +14 authors, Jonathan Rosenberg. less J Clin Oncol, 2019 May 18; 37(19). PMID: 31100038 Free PMC article.
The next decade of clinical trials in locoregionally advanced nasopharyngeal carcinoma. Liang Peng, Jin-Qi Liu, Yu-Pei Chen, Jun Ma. Br J Radiol, 2019 May 22; 92(1102). PMID: 31112398 Free PMC article. Review.
Systemic immune-inflammation index, neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio can predict clinical outcomes in patients with metastatic non-small-cell lung cancer treated with nivolumab. Jingjing Liu, Shuang Li, +7 authors, Ying Cheng. less J Clin Lab Anal, 2019 Jul 10; 33(8). PMID: 31282096 Free PMC article. Highly Cited.
Change in neutrophil to lymphocyte ratio during immunotherapy treatment is a non-linear predictor of patient outcomes in advanced cancers. Mingjia Li, Daniel Spakowicz, +11 authors, Dwight H Owen. less J Cancer Res Clin Oncol, 2019 Aug 02; 145(10). PMID: 31367835 Free PMC article.
Novel Delivery Systems for Checkpoint Inhibitors. Purushottam Lamichhane, Rahul Deshmukh, +8 authors, Narottam Lamichhane. less Medicines (Basel), 2019 Aug 03; 6(3). PMID: 31373327 Free PMC article. Review.
Antitumor T-cell Homeostatic Activation Is Uncoupled from Homeostatic Inhibition by Checkpoint Blockade. Netonia Marshall, Keino Hutchinson, +7 authors, Joshua D Brody. less Cancer Discov, 2019 Aug 04; 9(11). PMID: 31375522 Free PMC article.
Imaging of Precision Therapy for Lung Cancer: Current State of the Art. Hyesun Park, Lynette M Sholl, +2 authors, Hiroto Hatabu, Mark M Awad, Mizuki Nishino. less Radiology, 2019 Aug 07; 293(1). PMID: 31385753 Free PMC article. Review.
Myocarditis in the Setting of Cancer Therapeutics: Proposed Case Definitions for Emerging Clinical Syndromes in Cardio-Oncology Marc P Bonaca, Benjamin A Olenchock, +17 authors, Javid Moslehi. less Circulation, 2019 Aug 08; 140(2). PMID: 31390169 Free PMC article. Highly Cited. Review.
The Genomic Landscape of Merkel Cell Carcinoma and Clinicogenomic Biomarkers of Response to Immune Checkpoint Inhibitor Therapy. Todd C Knepper, Meagan Montesion, +13 authors, Andrew S Brohl. less Clin Cancer Res, 2019 Aug 11; 25(19). PMID: 31399473 Free PMC article.
Characterizing the Feasibility and Performance of Real-World Tumor Progression End Points and Their Association With Overall Survival in a Large Advanced Non-Small-Cell Lung Cancer Data Set. Sandra D Griffith, Rebecca A Miksad, +10 authors, Amy P Abernethy. less JCO Clin Cancer Inform, 2019 Aug 14; 3. PMID: 31403818 Free PMC article.
Microsatellite-Stable Tumors with High Mutational Burden Benefit from Immunotherapy. Aaron M Goodman, Ethan S Sokol, +2 authors, Garrett M Frampton, Scott M Lippman, Razelle Kurzrock. less Cancer Immunol Res, 2019 Aug 14; 7(10). PMID: 31405947 Free PMC article.
Panel-based estimates of tumor mutational burden: characterizing unknown unknowns. W Yang, L G T Morris, T A Chan. Ann Oncol, 2019 Aug 15; 30(9). PMID: 31410441 Free PMC article.
Existing and Emerging Biomarkers for Immune Checkpoint Immunotherapy in Solid Tumors. Sanjeevani Arora, Rodion Velichinskii, +6 authors, Yanis Boumber. less Adv Ther, 2019 Aug 15; 36(10). PMID: 31410780 Free PMC article. Review.
Identification of Recurrent Activating HER2 Mutations in Primary Canine Pulmonary Adenocarcinoma. Gwendolen Lorch, Karthigayini Sivaprakasam, +16 authors, William P D Hendricks. less Clin Cancer Res, 2019 Aug 23; 25(19). PMID: 31431454 Free PMC article.
Novel Biomarkers for Personalized Cancer Immunotherapy. Yoshitaro Shindo, Shoichi Hazama, +2 authors, Ryouichi Tsunedomi, Nobuaki Suzuki, Hiroaki Nagano. less Cancers (Basel), 2019 Aug 25; 11(9). PMID: 31443339 Free PMC article. Review.
Circulating biomarkers predictive of tumor response to cancer immunotherapy. Ernest Y Lee, Rajan P Kulkarni. Expert Rev Mol Diagn, 2019 Aug 31; 19(10). PMID: 31469965 Free PMC article. Review.
Plasma Biomarkers and Immune Checkpoint Inhibitors in Non-Small Cell Lung Cancer: New Tools for Better Patient Selection? Adrien Costantini, Paul Takam Kamga, +3 authors, Etienne Giroux Leprieur. less Cancers (Basel), 2019 Sep 01; 11(9). PMID: 31470546 Free PMC article. Review.
In-house Implementation of Tumor Mutational Burden Testing to Predict Durable Clinical Benefit in Non-small Cell Lung Cancer and Melanoma Patients. Simon Heeke, Jonathan Benzaquen, +17 authors, Paul Hofman. less Cancers (Basel), 2019 Sep 01; 11(9). PMID: 31470674 Free PMC article.
The efficacy of immune checkpoint inhibitors in anaplastic lymphoma kinase-positive non-small cell lung cancer. Ja Yoon Heo, Changhee Park, +8 authors, Dae Seog Heo. less Thorac Cancer, 2019 Sep 12; 10(11). PMID: 31509890 Free PMC article.
Knowledge Gaps and Research Priorities in Immune Checkpoint Inhibitor-related Pneumonitis. An Official American Thoracic Society Research Statement. Catherine R Sears, Tobias Peikert, +11 authors, M Patricia Rivera. less Am J Respir Crit Care Med, 2019 Sep 14; 200(6). PMID: 31518182 Free PMC article.
[Research Progress of Immune Checkpoint Inhibitor Therapy for BRAF Mutation  in Non-small Cell Lung Cancer]. Xia Liu, Diansheng Zhong. Zhongguo Fei Ai Za Zhi, 2019 Sep 19; 22(9). PMID: 31526463 Free PMC article. Review.
Immune Checkpoint Inhibitors as Switch or Continuation Maintenance Therapy in Solid Tumors: Rationale and Current State. Petros Grivas, Bradley J Monk, +6 authors, Markus Moehler. less Target Oncol, 2019 Sep 20; 14(5). PMID: 31535338 Review.
Association of Tumor Protein p53 and Ataxia-Telangiectasia Mutated Comutation With Response to Immune Checkpoint Inhibitors and Mortality in Patients With Non-Small Cell Lung Cancer. Yu Chen, Gang Chen, +14 authors, Jian-Ji Pan. less JAMA Netw Open, 2019 Sep 21; 2(9). PMID: 31539077 Free PMC article.
Monoclonal Antibodies in Dermatooncology-State of the Art and Future Perspectives. Malgorzata Bobrowicz, Radoslaw Zagozdzon, +3 authors, Magdalena Winiarska. less Cancers (Basel), 2019 Sep 27; 11(10). PMID: 31554169 Free PMC article. Review.
A retrospective study evaluating the pretreatment tumor volume (PTV) in non-small cell lung cancer (NSCLC) as a predictor of response to program death-1 (PD-1) inhibitors. Misako Nagasaka, Nadine Abdallah, +6 authors, Ammar Sukari. less Lung Cancer (Auckl), 2019 Oct 02; 10. PMID: 31572037 Free PMC article.
Prognostic Factors and Biomarkers of Responses to Immune Checkpoint Inhibitors in Lung Cancer. Andrea Bianco, Fabio Perrotta, +3 authors, Raffaele De Palma. less Int J Mol Sci, 2019 Oct 09; 20(19). PMID: 31590386 Free PMC article. Review.
Lynch syndrome-associated ultra-hypermutated pediatric glioblastoma mimicking a constitutional mismatch repair deficiency syndrome. Chen Yang, Frances Austin, +5 authors, Scott A Turner. less Cold Spring Harb Mol Case Stud, 2019 Oct 13; 5(5). PMID: 31604779 Free PMC article.
Immune checkpoint inhibitors for the treatment of MSI-H/MMR-D colorectal cancer and a perspective on resistance mechanisms. Ibrahim Halil Sahin, Mehmet Akce, +4 authors, Christina Wu. less Br J Cancer, 2019 Oct 15; 121(10). PMID: 31607751 Free PMC article. Review.
Checkpoint inhibitors plus chemotherapy for first-line treatment of advanced non-small cell lung cancer: a systematic review and meta-analysis of randomized controlled trials. Aung Myint Tun, Kyaw Zin Thein, Wai Lin Thein, Elizabeth Guevara. Future Sci OA, 2019 Oct 15; 5(9). PMID: 31608159 Free PMC article. Review.
Pembrolizumab Induced Ocular Hypotony With Near Complete Vision Loss, Interstitial Pulmonary Fibrosis and Arthritis. Mike Nguyen, Md Rafiqul Islam, +2 authors, Shueh Wen Lim, Arvind Sahu, Babak Tamjid. less Front Oncol, 2019 Oct 15; 9. PMID: 31608234 Free PMC article.
New Horizons in KRAS-Mutant Lung Cancer: Dawn After Darkness. Haitang Yang, Shun-Qing Liang, Ralph A Schmid, Ren-Wang Peng. Front Oncol, 2019 Oct 16; 9. PMID: 31612108 Free PMC article. Review.
NK Cell-Fc Receptors Advance Tumor Immunotherapy. Emilio Sanseviero. J Clin Med, 2019 Oct 17; 8(10). PMID: 31614774 Free PMC article. Review.
Nivolumab-induced cholangitis in patients with non-small cell lung cancer: Case series and a review of literature. Hiroki Izumi, Masahiro Kodani, +13 authors, Akira Yamasaki. less Mol Clin Oncol, 2019 Oct 17; 11(5). PMID: 31616560 Free PMC article.
Co-mutations of TP53 and KRAS serve as potential biomarkers for immune checkpoint blockade in squamous-cell non-small cell lung cancer: a case report. Cheng Fang, Chu Zhang, +3 authors, Wei-Qing Zhao, Wen-Wei Hu, Jun Wu, Mei Ji. less BMC Med Genomics, 2019 Oct 18; 12(1). PMID: 31619231 Free PMC article.
Extracellular NK histones promote immune cell anti-tumor activity by inducing cell clusters through binding to CD138 receptor. B Martín-Antonio, G Suñe, +12 authors, A Urbano-Ispizua. less J Immunother Cancer, 2019 Oct 18; 7(1). PMID: 31619273 Free PMC article.
Alteration in TET1 as potential biomarker for immune checkpoint blockade in multiple cancers. Hao-Xiang Wu, Yan-Xing Chen, +5 authors, Rui-Hua Xu. less J Immunother Cancer, 2019 Oct 19; 7(1). PMID: 31623662 Free PMC article.
Decreased IFIT2 Expression In Human Non-Small-Cell Lung Cancer Tissues Is Associated With Cancer Progression And Poor Survival Of The Patients. Wenya Su, Wenlu Xiao, +5 authors, Zhigang Wang. less Onco Targets Ther, 2019 Oct 22; 12. PMID: 31632065 Free PMC article.
Blood tumor mutational burden: are we ready for clinical implementation? Claude Van Campenhout, Bárbara Meléndez, +2 authors, Myriam Remmelink, Isabelle Salmon, Nicky D'Haene. less J Thorac Dis, 2019 Oct 22; 11(Suppl 15). PMID: 31632782 Free PMC article.
Comparative Safety of PD-1/PD-L1 Inhibitors for Cancer Patients: Systematic Review and Network Meta-Analysis. Ya-Fang Huang, Wen-Jie Xie, Hai-Yu Fan, Juan Du. Front Oncol, 2019 Oct 22; 9. PMID: 31632907 Free PMC article. Systematic Review.
Validation of computational determination of microsatellite status using whole exome sequencing data from colorectal cancer patients. Amanda Frydendahl Boll Johansen, Christine Gaasdal Kassentoft, +6 authors, Claus Lindbjerg Andersen. less BMC Cancer, 2019 Oct 23; 19(1). PMID: 31638937 Free PMC article.
Pan-cancer whole-genome analyses of metastatic solid tumours. Peter Priestley, Jonathan Baber, +18 authors, Edwin Cuppen. less Nature, 2019 Oct 28; 575(7781). PMID: 31645765 Free PMC article. Highly Cited.
Fewer actionable mutations but higher tumor mutational burden characterizes NSCLC in black patients at an urban academic medical center. Noura J Choudhury, Mansooreh Eghtesad, +5 authors, Jyoti D Patel. less Oncotarget, 2019 Oct 28; 10(56). PMID: 31645901 Free PMC article.
MiRNA expression patterns are associated with tumor mutational burden in lung adenocarcinoma. Yufeng Lv, Zhong Huang, +5 authors, Zihai Xu. less Oncoimmunology, 2019 Oct 28; 8(10). PMID: 31646073 Free PMC article.
A synergistic triad of chemotherapy, immune checkpoint inhibitors, and caloric restriction mimetics eradicates tumors in mice. Sarah Lévesque, Julie Le Naour, +12 authors, Jonathan G Pol. less Oncoimmunology, 2019 Oct 28; 8(11). PMID: 31646107 Free PMC article.
Therapy Line and Associated Predictors of Response to PD-1/PD-L1-Inhibitor Monotherapy in Advanced Non-small-Cell Lung Cancer: A Retrospective Bi-centric Cohort Study. David Lang, Florian Huemer, +9 authors, Bernd Lamprecht. less Target Oncol, 2019 Oct 28; 14(6). PMID: 31654203 Free PMC article.
Impact of clinicopathological features on the efficacy of immune checkpoint inhibitors plus conventional treatment in patients with advanced lung cancer. Guanghui Gao, Meng Qiao, +8 authors, Caicun Zhou. less J Thorac Dis, 2019 Oct 28; 11(9). PMID: 31656652 Free PMC article.
A modified recursive partitioning analysis for predicting overall survival in patients with non-small cell lung cancer and central nervous system metastases. Thiago Pimentel Muniz, Victor Hugo Fonseca de Jesus, +2 authors, Vladmir Cláudio Cordeiro de Lima. less J Thorac Dis, 2019 Oct 28; 11(9). PMID: 31656665 Free PMC article.
Evolution of the nonsense-mediated decay pathway is associated with decreased cytolytic immune infiltration. Boyang Zhao, Justin R Pritchard. PLoS Comput Biol, 2019 Oct 29; 15(10). PMID: 31658270 Free PMC article.
Comprehensive analysis of POLE and POLD1 Gene Variations identifies cancer patients potentially benefit from immunotherapy in Chinese population. Jianfei Yao, Yuan Gong, +12 authors, Lele Song. less Sci Rep, 2019 Nov 02; 9(1). PMID: 31673068 Free PMC article.
Genetic mapping of pancreatic cancer by targeted next-generation sequencing in a cohort of patients managed with nab-paclitaxel-based chemotherapy or agents targeting the EGFR axis: a retrospective analysis of the Hellenic Cooperative Oncology Group (HeCOG). George Zarkavelis, Vassiliki Kotoula, +17 authors, George Pentheroudakis. less ESMO Open, 2019 Nov 02; 4(5). PMID: 31673425 Free PMC article.
The efficacy and safety of combination of PD-1 and CTLA-4 inhibitors: a meta-analysis. Kongju Wu, Ming Yi, +3 authors, Shuang Qin, Qian Chu, Xinhua Zheng, Kongming Wu. less Exp Hematol Oncol, 2019 Nov 02; 8. PMID: 31673481 Free PMC article. Review.
PACIFIC: shifting tides in the treatment of locally advanced non-small cell lung cancer. Andrew Bang, Jonathan D Schoenfeld, Alexander Y Sun. Transl Lung Cancer Res, 2019 Nov 02; 8(Suppl 2). PMID: 31673518 Free PMC article. Review.
The tumor inflammation signature (TIS) is associated with anti-PD-1 treatment benefit in the CERTIM pan-cancer cohort. Diane Damotte, Sarah Warren, +21 authors, Karen Leroy. less J Transl Med, 2019 Nov 07; 17(1). PMID: 31684954 Free PMC article.
Fostering efficacy of anti-PD-1-treatment: Nivolumab plus radiotherapy in advanced non-small cell lung cancer - study protocol of the FORCE trial. Farastuk Bozorgmehr, Adriane Hommertgen, +9 authors, Stefan Rieken. less BMC Cancer, 2019 Nov 11; 19(1). PMID: 31703637 Free PMC article.
The Differences in the Safety and Tolerability of Immune Checkpoint Inhibitors as Treatment for Non-Small Cell Lung Cancer and Melanoma: Network Meta-Analysis and Systematic Review. Qing-Qing Chai, Jiang-Yang Du, Jun Zhu, Bin Wu. Front Pharmacol, 2019 Nov 12; 10. PMID: 31708783 Free PMC article. Systematic Review.
PRISM protocol: a randomised phase II trial of nivolumab in combination with alternatively scheduled ipilimumab in first-line treatment of patients with advanced or metastatic renal cell carcinoma. Hannah L Buckley, Fiona J Collinson, +15 authors, Naveen S Vasudev. less BMC Cancer, 2019 Nov 16; 19(1). PMID: 31727024 Free PMC article.
KEYNOTE-021 cohorts D and H suggest modest benefit in combining ipilimumab with pembrolizumab in second-line or later advanced non-small cell lung cancer treatment. Amy Lauren Cummings, Kate M Santoso, Jonathan W Goldman. Transl Lung Cancer Res, 2019 Nov 19; 8(5). PMID: 31737507 Free PMC article.
Immunotherapy in EGFR mutant non-small cell lung cancer: when, who and how? Debora Bruno, Afshin Dowlati. Transl Lung Cancer Res, 2019 Nov 19; 8(5). PMID: 31737508 Free PMC article.
The KEY to the end of the chemotherapy in advanced non-small cell lung cancer, or not yet? Yiqing Huang, Robert J Walsh, Ross A Soo. Transl Lung Cancer Res, 2019 Nov 19; 8(5). PMID: 31737512 Free PMC article.
Antitumor Activity and Treatment-Related Toxicity Associated With Nivolumab Plus Ipilimumab in Advanced Malignancies: A Systematic Review and Meta-Analysis. Hang Xu, Ping Tan, +5 authors, Qiang Wei. less Front Pharmacol, 2019 Nov 22; 10. PMID: 31749704 Free PMC article. Systematic Review.
The Predictive Value of Tumor Mutation Burden on Efficacy of Immune Checkpoint Inhibitors in Cancers: A Systematic Review and Meta-Analysis. Yongfeng Wu, Jinming Xu, +4 authors, Jian Hu. less Front Oncol, 2019 Nov 22; 9. PMID: 31750249 Free PMC article. Systematic Review.
Tumor mutational burden in lung cancer: a systematic literature review. Connor Willis, Michelle Fiander, +6 authors, David D Stenehjem. less Oncotarget, 2019 Nov 26; 10(61). PMID: 31762941 Free PMC article. Review.
Immune-Checkpoint Inhibitors as the First Line Treatment of Advanced Non-Small Cell Lung Cancer: A Meta-Analysis of Randomized Controlled Trials. Yuqiao Chen, Yuan Zhou, +4 authors, Wei Zhuang. less J Cancer, 2019 Nov 28; 10(25). PMID: 31772659 Free PMC article. Review.
Clinical and Molecular Predictors of Response to Immune Checkpoint Inhibitors in Patients with Advanced Esophagogastric Cancer. Megan Greally, Joanne F Chou, +16 authors, Geoffrey Y Ku. less Clin Cancer Res, 2019 Jul 25; 25(20). PMID: 31337644 Free PMC article.
Development and clinical applications of cancer immunotherapy against PD-1 signaling pathway. Grace Wakabayashi, Yu-Ching Lee, +3 authors, Yun Yen. less J Biomed Sci, 2019 Dec 06; 26(1). PMID: 31801525 Free PMC article. Review.
Setting the scene - a future 'epidemic' of immune-related adverse events in association with checkpoint inhibitor therapy. Maria V Bermudez, Sophie Papa. Rheumatology (Oxford), 2019 Dec 10; 58(Suppl 7). PMID: 31816083 Free PMC article. Review.
A Molecular Epidemiological Analysis Of Programmed Cell Death Ligand-1 (PD-L1) Protein Expression, Mutations And Survival In Non-Small Cell Lung Cancer. Matthew B Schabath, Tapashi B Dalvi, +13 authors, Jhanelle E Gray. less Cancer Manag Res, 2019 Dec 11; 11. PMID: 31819612 Free PMC article.
Lung and Gut Microbiota as Potential Hidden Driver of Immunotherapy Efficacy in Lung Cancer. Carmine Carbone, Geny Piro, +9 authors, Emilio Bria. less Mediators Inflamm, 2019 Dec 13; 2019. PMID: 31827379 Free PMC article. Review.
[Importance of tumour mutation burden testing]. Peter J Wild. Pathologe, 2019 Dec 07; 40(Suppl 3). PMID: 31807843
Biomarker for personalized immunotherapy. Si-Yang Liu, Yi-Long Wu. Transl Lung Cancer Res, 2019 Dec 21; 8(Suppl 3). PMID: 31857954 Free PMC article. Review.
Hyperprogressive Disease during Anti-PD-1 (PDCD1) / PD-L1 (CD274) Therapy: A Systematic Review and Meta-Analysis. Jong Yeob Kim, Keum Hwa Lee, +12 authors, Gabriele Gamerith. less Cancers (Basel), 2019 Nov 07; 11(11). PMID: 31683809 Free PMC article.
Tumor Mutational Burden and Efficacy of Immune Checkpoint Inhibitors: A Systematic Review and Meta-Analysis. Jong Yeob Kim, Andreas Kronbichler, +5 authors, Gabriele Gamerith. less Cancers (Basel), 2019 Nov 17; 11(11). PMID: 31731749 Free PMC article.
Harmonization of Tumor Mutational Burden Quantification and Association With Response to Immune Checkpoint Blockade in Non-Small-Cell Lung Cancer. Natalie I Vokes, David Liu, +19 authors, Mark M Awad. less JCO Precis Oncol, 2019 Dec 14; 3. PMID: 31832578 Free PMC article.
MicroRNAs in non-small cell lung cancer: Gene regulation, impact on cancer cellular processes, and therapeutic potential. Hannah Petrek, Ai-Ming Yu. Pharmacol Res Perspect, 2019 Dec 21; 7(6). PMID: 31859460 Free PMC article. Review.
Risk of immune-related diarrhea with PD-1/PD-L1 inhibitors in different cancer types and treatment regimens. Lei Zhao, Jing Yu, +3 authors, Jing Wang, Huihui Li, Juanjuan Che, Bangwei Cao. less J Cancer, 2020 Jan 02; 11(1). PMID: 31892971 Free PMC article.
Significant function and research progress of biomarkers in gastric cancer. Dong Mei Ye, Gaosheng Xu, +5 authors, Zhiwei Zhang. less Oncol Lett, 2020 Jan 04; 19(1). PMID: 31897111 Free PMC article. Review.
Hijacking antibody-induced CTLA-4 lysosomal degradation for safer and more effective cancer immunotherapy. Yan Zhang, Xuexiang Du, +9 authors, Yang Liu. less Cell Res, 2019 Jul 04; 29(8). PMID: 31267017 Free PMC article.
The effect of PD-L1/PD-1 immunotherapy in the treatment of squamous non-small-cell lung cancer: a meta-analysis of randomized controlled clinical trials. Shuang Li, Shuang Zhang, +3 authors, Ying Cheng. less J Thorac Dis, 2020 Jan 07; 11(11). PMID: 31903233 Free PMC article.
PD-1 Inhibitors in the Advanced Esophageal Cancer. Ye Hong, Zhen-Yu Ding. Front Pharmacol, 2020 Jan 11; 10. PMID: 31920637 Free PMC article. Review.
Neoantigens in Hematological Malignancies-Ultimate Targets for Immunotherapy? Malte Roerden, Annika Nelde, Juliane S Walz. Front Immunol, 2020 Jan 11; 10. PMID: 31921218 Free PMC article. Review.
Isolation and Identification of Cancer Stem-Like Cells in Adenocarcinoma and Squamous Cell Carcinoma of the Lung: A Pilot Study. Valentina Masciale, Giulia Grisendi, +7 authors, Beatrice Aramini. less Front Oncol, 2020 Jan 11; 9. PMID: 31921651 Free PMC article.
Maximum Somatic Allele Frequency in Combination With Blood-Based Tumor Mutational Burden to Predict the Efficacy of Atezolizumab in Advanced Non-small Cell Lung Cancer: A Pooled Analysis of the Randomized POPLAR and OAK Studies. Yu-Tong Chen, Sharvesh Raj Seeruttun, Xiang-Yuan Wu, Zi-Xian Wang. Front Oncol, 2020 Jan 11; 9. PMID: 31921683 Free PMC article.
Severe Immune-Related Pneumonitis With PD-1 Inhibitor After Progression on Previous PD-L1 Inhibitor in Small Cell Lung Cancer: A Case Report and Review of the Literature. Xiuju Liang, Yaping Guan, +4 authors, Jun Wang. less Front Oncol, 2020 Jan 11; 9. PMID: 31921686 Free PMC article.
Anti-CTLA-4 Activates Intratumoral NK Cells and Combined with IL15/IL15Rα Complexes Enhances Tumor Control. Emilio Sanseviero, Erin M O'Brien, +16 authors, Erica L Stone. less Cancer Immunol Res, 2019 Jun 27; 7(8). PMID: 31239316 Free PMC article.
Tumor mutational and indel burden: a systematic pan-cancer evaluation as prognostic biomarkers. Hao-Xiang Wu, Zi-Xian Wang, +9 authors, Feng Wang. less Ann Transl Med, 2020 Jan 14; 7(22). PMID: 31930041 Free PMC article.
Identification of a small mutation panel of coding sequences to predict the efficacy of immunotherapy for lung adenocarcinoma. Ying Li, Wenbin Jiang, +10 authors, Zheng Guo. less J Transl Med, 2020 Jan 16; 18(1). PMID: 31937321 Free PMC article.
Anti-PD-1 Therapy plus Chemotherapy and/or Bevacizumab as Second Line or later Treatment for Patients with Advanced Non-Small Cell Lung Cancer. Fan Zhang, Di Huang, +13 authors, Yi Hu. less J Cancer, 2020 Jan 17; 11(3). PMID: 31942197 Free PMC article.
Patterns and genomic correlates of PD-L1 expression in patients with biliary tract cancers. Kabir Mody, Jason Starr, +5 authors, Anthony F Shields. less J Gastrointest Oncol, 2020 Jan 18; 10(6). PMID: 31949927 Free PMC article.
Amplifying Outcomes: Checkpoint Inhibitor Combinations in First-Line Non-Small Cell Lung Cancer. Barbara Melosky, Rosalyn Juergens, +5 authors, Quincy Chu. less Oncologist, 2019 May 30; 25(1). PMID: 31138727 Free PMC article.
Tumor Mutational Burden as a Predictive Biomarker for Response to Immune Checkpoint Inhibitors: A Review of Current Evidence. Samuel J Klempner, David Fabrizio, +8 authors, Prasanth Reddy. less Oncologist, 2019 Oct 04; 25(1). PMID: 31578273 Free PMC article. Review.
Association Between Preanalytical Factors and Tumor Mutational Burden Estimated by Next-Generation Sequencing-Based Multiplex Gene Panel Assay. Pham Nguyen Quy, Masashi Kanai, +16 authors, Manabu Muto. less Oncologist, 2019 Jun 13; 24(12). PMID: 31186376 Free PMC article.
Odds ratio of programmed cell death-1 or ligand 1 inhibitor-related endocrine dysfunction in patients with lung cancer: A systematic review and meta-analysis. Jian Xie, Zewen Zhang, +4 authors, Yuan Tian. less Medicine (Baltimore), 2019 Dec 20; 98(50). PMID: 31852114 Free PMC article. Systematic Review.
Tumor mutational burden assessed by targeted NGS predicts clinical benefit from immune checkpoint inhibitors in non-small cell lung cancer. Ilaria Alborelli, Katharina Leonards, +12 authors, Philip Jermann. less J Pathol, 2019 Sep 01; 250(1). PMID: 31471895 Free PMC article.
Therapeutic Monoclonal Antibodies Targeting Immune Checkpoints for the Treatment of Solid Tumors. Nicholas Gravbrot, Kacy Gilbert-Gard, +4 authors, Srinath Sundararajan. less Antibodies (Basel), 2019 Oct 24; 8(4). PMID: 31640266 Free PMC article. Review.
Rationale of Immunotherapy in Hepatocellular Carcinoma and Its Potential Biomarkers. David Tai, Su Pin Choo, Valerie Chew. Cancers (Basel), 2019 Dec 11; 11(12). PMID: 31816940 Free PMC article. Review.
Immune gene signatures for predicting durable clinical benefit of anti-PD-1 immunotherapy in patients with non-small cell lung cancer. Sohyun Hwang, Ah-Young Kwon, +7 authors, Hee Jung An. less Sci Rep, 2020 Jan 22; 10(1). PMID: 31959763 Free PMC article.
First-line PD-1/PD-L1 inhibitor plus chemotherapy vs chemotherapy alone for negative or < 1% PD-L1-expressing metastatic non-small-cell lung cancers. Thierry Landre, Gaetan Des Guetz, +3 authors, Christos Chouaïd. less J Cancer Res Clin Oncol, 2019 Nov 07; 146(2). PMID: 31686247
Efficacy and safety of first-line pembrolizumab monotherapy in elderly patients (aged ≥ 75 years) with non-small cell lung cancer. Hisao Imai, Satoshi Wasamoto, +15 authors, Kyoichi Kaira. less J Cancer Res Clin Oncol, 2019 Dec 20; 146(2). PMID: 31853661
Biomarkers Predictive of Survival and Response to Immune Checkpoint Inhibitors in Melanoma. Emanuelle M Rizk, Angelina M Seffens, +5 authors, Yvonne M Saenger. less Am J Clin Dermatol, 2019 Oct 12; 21(1). PMID: 31602560 Free PMC article. Review.
Evaluating the role of FAMIly history of cancer and diagnosis of multiple neoplasms in cancer patients receiving PD-1/PD-L1 checkpoint inhibitors: the multicenter FAMI-L1 study. Alessio Cortellini, Sebastiano Buti, +46 authors, Corrado Ficorella. less Oncoimmunology, 2020 Feb 01; 9(1). PMID: 32002308 Free PMC article.
Targeted literature review on use of tumor mutational burden status and programmed cell death ligand 1 expression to predict outcomes of checkpoint inhibitor treatment. Tina Krieger, Isobel Pearson, +2 authors, Judith Bell, Jim Doherty, Paul Robbins. less Diagn Pathol, 2020 Feb 01; 15(1). PMID: 32000815 Free PMC article. Review.
Comprehensive T cell repertoire characterization of non-small cell lung cancer. Alexandre Reuben, Jiexin Zhang, +55 authors, Jianjun Zhang. less Nat Commun, 2020 Feb 01; 11(1). PMID: 32001676 Free PMC article.
EPSILoN: A Prognostic Score for Immunotherapy in Advanced Non-Small-Cell Lung Cancer: A Validation Cohort. Arsela Prelaj, Roberto Ferrara, +19 authors, Giuseppe Lo Russo. less Cancers (Basel), 2019 Dec 11; 11(12). PMID: 31817541 Free PMC article.
Cost-effectiveness of pembrolizumab for advanced non-small cell lung cancer patients with varying comorbidity burden. Steven D Criss, Lauren Palazzo, +4 authors, Chung Yin Kong. less PLoS One, 2020 Jan 30; 15(1). PMID: 31995619 Free PMC article.
Phagocytosis checkpoints as new targets for cancer immunotherapy. Mingye Feng, Wen Jiang, +3 authors, Irving L Weissman. less Nat Rev Cancer, 2019 Aug 30; 19(10). PMID: 31462760 Free PMC article. Highly Cited. Review.
Tumor immune response and immunotherapy in gastric cancer. Yoonjin Kwak, An Na Seo, Hee Eun Lee, Hye Seung Lee. J Pathol Transl Med, 2019 Nov 02; 54(1). PMID: 31674166 Free PMC article. Review.
Association of the prognostic model iSEND with PD-1/L1 monotherapy outcome in non-small-cell lung cancer. Wungki Park, Laura Mezquita, +14 authors, Gilberto Lopes. less Br J Cancer, 2019 Nov 26; 122(3). PMID: 31761899 Free PMC article.
Oncogene addiction and tumor mutational burden in non-small-cell lung cancer: Clinical significance and limitations. Elisabeth Smolle, Katharina Leithner, Horst Olschewski. Thorac Cancer, 2019 Dec 05; 11(2). PMID: 31799812 Free PMC article. Review.
Immunotherapy at any line of treatment improves survival in patients with advanced metastatic non-small cell lung cancer (NSCLC) compared with chemotherapy (Quijote-CLICaP). Alejandro Ruiz-Patiño, Oscar Arrieta, +28 authors, CLICaP. less Thorac Cancer, 2019 Dec 13; 11(2). PMID: 31828967 Free PMC article.
Advances in clinical trials of targeted therapy and immunotherapy of lung cancer in 2018. Zhengyang Hu, Ming Li, +3 authors, Qun Wang. less Transl Lung Cancer Res, 2020 Feb 06; 8(6). PMID: 32010587 Free PMC article. Review.
EGFR mutations in lung cancer: not all equal in the eyes of the immune system? Kwun M Fong, Brett G M Hughes, Zarnie Lwin, Ian A Yang. Ann Transl Med, 2020 Feb 06; 7(Suppl 8). PMID: 32016044 Free PMC article.
Beyond PD-L1 Markers for Lung Cancer Immunotherapy. Kamila Wojas-Krawczyk, Ewa Kalinka, +2 authors, Anna Grenda, Paweł Krawczyk, Janusz Milanowski. less Int J Mol Sci, 2019 Apr 21; 20(8). PMID: 31003463 Free PMC article. Review.
Gut metabolomics profiling of non-small cell lung cancer (NSCLC) patients under immunotherapy treatment. Andrea Botticelli, Pamela Vernocchi, +13 authors, Paolo Marchetti. less J Transl Med, 2020 Feb 06; 18(1). PMID: 32014010 Free PMC article.
Targeted next-generation sequencing to assess tumor mutation burden: ready for prime-time in non-small cell lung cancer? Pascale Tomasini, Laurent Greillier. Transl Lung Cancer Res, 2020 Feb 11; 8(Suppl 4). PMID: 32038906 Free PMC article.
Broad-based genomic sequencing in advanced non-small cell lung cancer in the dock. Caterina Fumagalli, Elena Guerini-Rocco, Massimo Barberis. Transl Lung Cancer Res, 2020 Feb 11; 8(Suppl 4). PMID: 32038915 Free PMC article.
Y-box binding protein-1 is crucial in acquired drug resistance development in metastatic clear-cell renal cell carcinoma. Ninadh M D'Costa, Matthew R Lowerison, +9 authors, Alan I So. less J Exp Clin Cancer Res, 2020 Feb 12; 39(1). PMID: 32041631 Free PMC article.
[Immunohistochemical and molecular pathological diagnosis of lung carcinoma]. Britta Janina Wagner, Reinhard Buettner. Pathologe, 2020 Jan 15; 41(1). PMID: 31932944 Review.
The double-edged sword of cancer mutations: exploiting neoepitopes for the fight against cancer. Isabel Alvarado-Cruz, Rithy Meas, +3 authors, Joann Balazs Sweasy. less Mutagenesis, 2019 Dec 28; 35(1). PMID: 31880305 Free PMC article. Review.
Identification of gene signature for treatment response to guide precision oncology in clear-cell renal cell carcinoma. Ninadh M D'Costa, Davide Cina, +8 authors, Alan I So. less Sci Rep, 2020 Feb 08; 10(1). PMID: 32029828 Free PMC article.
A pilot trial of pembrolizumab plus prostatic cryotherapy for men with newly diagnosed oligometastatic hormone-sensitive prostate cancer. Ashley E Ross, Paula J Hurley, +9 authors, Emmanuel S Antonarakis. less Prostate Cancer Prostatic Dis, 2019 Oct 16; 23(1). PMID: 31611635 Free PMC article.
Tumor Mutation Burden as a Potential Biomarker for PD-1/PD-L1 Inhibition in Advanced Non-small Cell Lung Cancer. Di Huang, Fan Zhang, +10 authors, Yi Hu. less Target Oncol, 2020 Feb 14; 15(1). PMID: 32052340
Organ-Specific Immune-Related Adverse Events Associated With Immune Checkpoint Inhibitor Monotherapy Versus Combination Therapy in Cancer: A Meta-Analysis of Randomized Controlled Trials. Lijun Da, Yuanjun Teng, +4 authors, Feixue Song. less Front Pharmacol, 2020 Feb 23; 10. PMID: 32082164 Free PMC article. Systematic Review.
The landscape of immune checkpoint inhibitor plus chemotherapy versus immunotherapy for advanced non-small-cell lung cancer: A systematic review and meta-analysis. Chengdi Wang, Wenliang Qiao, +5 authors, Weimin Li. less J Cell Physiol, 2019 Nov 07; 235(5). PMID: 31693178 Free PMC article. Systematic Review.
Predictive biomarkers of response to immune checkpoint inhibitors in melanoma. Caroline A Nebhan, Douglas B Johnson. Expert Rev Anticancer Ther, 2020 Jan 31; 20(2). PMID: 31997676 Free PMC article. Review.
A Rare Case of Advanced Urethral Diverticular Adenocarcinoma and a Review of Treatment Modalities. Fatai Oluyadi, Preethi Ramachandran, Vladmir Gotlieb. J Investig Med High Impact Case Rep, 2019 Feb 12; 7. PMID: 30739492 Free PMC article. Review.
Finding an Immunologic Beachhead in the Prostate Cancer Microenvironment. Ravi A Madan, James L Gulley. J Natl Cancer Inst, 2018 Oct 16; 111(3). PMID: 30321404 Free PMC article.
Race, Poverty, and Initial Implementation of Precision Medicine for Lung Cancer. Kenneth L Kehl, Christopher S Lathan, Bruce E Johnson, Deborah Schrag. J Natl Cancer Inst, 2018 Dec 24; 111(4). PMID: 30576459 Free PMC article.
Immune Checkpoint Blockade Enhances Shared Neoantigen-Induced T-cell Immunity Directed against Mutated Calreticulin in Myeloproliferative Neoplasms. Cansu Cimen Bozkus, Vladimir Roudko, +4 authors, Nina Bhardwaj. less Cancer Discov, 2019 Jul 04; 9(9). PMID: 31266769 Free PMC article.
Immunologic Biomarkers and Biomarkers for Immunotherapies in Gastrointestinal Cancer. Benedikt Martin, Bruno Märkl. Visc Med, 2019 Jul 18; 35(1). PMID: 31312644 Free PMC article. Review.
Assessment of Tumor Mutational Burden in Pediatric Tumors by Real-Life Whole-Exome Sequencing and In Silico Simulation of Targeted Gene Panels: How the Choice of Method Could Affect the Clinical Decision? Hana Noskova, Michal Kyr, +10 authors, Ondrej Slaby. less Cancers (Basel), 2020 Jan 23; 12(1). PMID: 31963488 Free PMC article.
Identification of biomarkers of immune checkpoint blockade efficacy in recurrent or refractory solid tumor malignancies. Richard K Yang, Yun Qing, +9 authors, Russell R Broaddus. less Oncotarget, 2020 Feb 29; 11(6). PMID: 32110280 Free PMC article.
Comparative Efficacy and Safety of Nivolumab and Nivolumab Plus Ipilimumab in Advanced Cancer: A Systematic Review and Meta-Analysis. Yi Yang, Gang Jin, +7 authors, Zijiang Zhu. less Front Pharmacol, 2020 Mar 03; 11. PMID: 32116716 Free PMC article. Systematic Review.
Tissue-Plasma TMB Comparison and Plasma TMB Monitoring in Patients With Metastatic Non-small Cell Lung Cancer Receiving Immune Checkpoint Inhibitors. Alex Friedlaender, Thierry Nouspikel, +3 authors, Alfredo Addeo. less Front Oncol, 2020 Mar 03; 10. PMID: 32117779 Free PMC article.
Current evidence and future perspectives of immune-checkpoint inhibitors in unresectable malignant pleural mesothelioma. Katsuyuki Hotta, Nobukazu Fujimoto. J Immunother Cancer, 2020 Feb 27; 8(1). PMID: 32098830 Free PMC article. Review.
Tumor Mutation Burden and Efficacy of EGFR-Tyrosine Kinase Inhibitors in Patients with EGFR-Mutant Lung Cancers. Michael Offin, Hira Rizvi, +12 authors, Matthew D Hellmann. less Clin Cancer Res, 2018 Jul 27; 25(3). PMID: 30045933 Free PMC article. Highly Cited.
Does TMB Impact the Effectiveness of TKIs in EGFR-Mutant NSCLC? Michael L Cheng, Geoffrey R Oxnard. Clin Cancer Res, 2018 Sep 08; 25(3). PMID: 30190372 Free PMC article.
Clinical Implications of Plasma-Based Genotyping With the Delivery of Personalized Therapy in Metastatic Non-Small Cell Lung Cancer. Charu Aggarwal, Jeffrey C Thompson, +18 authors, Erica L Carpenter. less JAMA Oncol, 2018 Oct 17; 5(2). PMID: 30325992 Free PMC article. Highly Cited.
The intimate relationship between gut microbiota and cancer immunotherapy. Arielle Elkrief, Lisa Derosa, +2 authors, Laurence Zitvogel, Guido Kroemer, Bertrand Routy. less Gut Microbes, 2018 Oct 20; 10(3). PMID: 30339501 Free PMC article.
Development of tumor mutation burden as an immunotherapy biomarker: utility for the oncology clinic. T A Chan, M Yarchoan, +4 authors, S Peters. less Ann Oncol, 2018 Nov 06; 30(1). PMID: 30395155 Free PMC article. Highly Cited. Review.
An adapted anti-CTLA4 therapeutic aimed at mitigating the toxicities of checkpoint inhibition. Jarushka Naidoo, Arbor Dykema, Franco D'Alessio. J Clin Invest, 2018 Dec 12; 129(1). PMID: 30530990 Free PMC article.
Cost-effectiveness and Budgetary Consequence Analysis of Durvalumab Consolidation Therapy vs No Consolidation Therapy After Chemoradiotherapy in Stage III Non-Small Cell Lung Cancer in the Context of the US Health Care System. Steven D Criss, Meghan J Mooradian, +5 authors, Chung Yin Kong. less JAMA Oncol, 2018 Dec 14; 5(3). PMID: 30543349 Free PMC article.
The prognostic significance of circulating tumor cells in head and neck and non-small-cell lung cancer. Arutha Kulasinghe, Joanna Kapeleris, +6 authors, Chamindie Punyadeera. less Cancer Med, 2018 Dec 20; 7(12). PMID: 30565869 Free PMC article.
DNA Mismatch Repair Deficiency and Immune Checkpoint Inhibitors in Gastrointestinal Cancers. Juan Ruiz-Bañobre, Ajay Goel. Gastroenterology, 2018 Dec 24; 156(4). PMID: 30578781 Free PMC article. Review.
PARP inhibition enhances tumor cell-intrinsic immunity in ERCC1-deficient non-small cell lung cancer. Roman M Chabanon, Gareth Muirhead, +20 authors, Sophie Postel-Vinay. less J Clin Invest, 2018 Dec 28; 129(3). PMID: 30589644 Free PMC article. Highly Cited.
Circulating miRNAs and PD-L1 Tumor Expression Are Associated with Survival in Advanced NSCLC Patients Treated with Immunotherapy: a Prospective Study. Mattia Boeri, Massimo Milione, +11 authors, Gabriella Sozzi. less Clin Cancer Res, 2019 Jan 09; 25(7). PMID: 30617131 Free PMC article.
Hyperspectral cell sociology reveals spatial tumor-immune cell interactions associated with lung cancer recurrence. Katey S S Enfield, Spencer D Martin, +10 authors, Martial Guillaud. less J Immunother Cancer, 2019 Jan 18; 7(1). PMID: 30651131 Free PMC article.
Tumor mutational burden standardization initiatives: Recommendations for consistent tumor mutational burden assessment in clinical samples to guide immunotherapy treatment decisions. Albrecht Stenzinger, Jeffrey D Allen, +4 authors, Manfred Dietel. less Genes Chromosomes Cancer, 2019 Jan 22; 58(8). PMID: 30664300 Free PMC article. Highly Cited. Review.
Insights into Molecular Classifications of Triple-Negative Breast Cancer: Improving Patient Selection for Treatment. Ana C Garrido-Castro, Nancy U Lin, Kornelia Polyak. Cancer Discov, 2019 Jan 27; 9(2). PMID: 30679171 Free PMC article. Highly Cited. Review.
Initial results of pulmonary resection after neoadjuvant nivolumab in patients with resectable non-small cell lung cancer. Matthew J Bott, Stephen C Yang, +11 authors, Stephen R Broderick. less J Thorac Cardiovasc Surg, 2019 Feb 06; 158(1). PMID: 30718052 Free PMC article.
Comparative efficacy and safety of first-line treatments for advanced non-small cell lung cancer with immune checkpoint inhibitors: A systematic review and meta-analysis. Rui Chen, Xiaoming Hou, Liping Yang, Da Zhao. Thorac Cancer, 2019 Feb 09; 10(4). PMID: 30734504 Free PMC article. Systematic Review.
Persistent mutant oncogene specific T cells in two patients benefitting from anti-PD-1. Kellie N Smith, Nicolas J Llosa, +38 authors, Franck Housseau. less J Immunother Cancer, 2019 Feb 13; 7(1). PMID: 30744692 Free PMC article.
Switch maintenance therapy with S-1 after induction therapy with carboplatin and nanoparticle albumin-bound paclitaxel in advanced lung squamous cell carcinoma. Norimichi Akiyama, Masato Karayama, +17 authors, Takafumi Suda. less Invest New Drugs, 2019 Feb 23; 37(3). PMID: 30790149
Evaluation of Two Dosing Regimens for Nivolumab in Combination With Ipilimumab in Patients With Advanced Melanoma: Results From the Phase IIIb/IV CheckMate 511 Trial. Celeste Lebbé, Nicolas Meyer, +16 authors, Jacopo Pigozzo. less J Clin Oncol, 2019 Feb 28; 37(11). PMID: 30811280 Free PMC article. Highly Cited.
Assessment of Blood Tumor Mutational Burden as a Potential Biomarker for Immunotherapy in Patients With Non-Small Cell Lung Cancer With Use of a Next-Generation Sequencing Cancer Gene Panel. Zhijie Wang, Jianchun Duan, +27 authors, Jie Wang. less JAMA Oncol, 2019 Mar 01; 5(5). PMID: 30816954 Free PMC article. Highly Cited.
Retrospect and Prospect for Lung Cancer in China: Clinical Advances of Immune Checkpoint Inhibitors. Shun Lu, Yongfeng Yu, Yi Yang. Oncologist, 2019 Mar 02; 24(Suppl 1). PMID: 30819828 Free PMC article. Review.
PD-1/PD-L1 Blockade Therapy in Advanced Non-Small-Cell Lung Cancer: Current Status and Future Directions. Liliang Xia, Yuanyong Liu, Ying Wang. Oncologist, 2019 Mar 02; 24(Suppl 1). PMID: 30819829 Free PMC article. Review.
Immunotherapy in Non-Small Cell Lung Cancer: Facts and Hopes. Deborah B Doroshow, Miguel F Sanmamed, +6 authors, Roy S Herbst. less Clin Cancer Res, 2019 Mar 03; 25(15). PMID: 30824587 Free PMC article. Highly Cited. Review.
Mutations in DNA repair genes are associated with increased neoantigen burden and a distinct immunophenotype in lung squamous cell carcinoma. Young Kwang Chae, Jonathan F Anker, +5 authors, Jeffrey H Chuang. less Sci Rep, 2019 Mar 03; 9(1). PMID: 30824826 Free PMC article.
Prognostic and Predictive Immunohistochemistry-Based Biomarkers in Cancer and Immunotherapy. Emanuelle M Rizk, Robyn D Gartrell, +4 authors, Yvonne M Saenger. less Hematol Oncol Clin North Am, 2019 Mar 06; 33(2). PMID: 30833001 Free PMC article. Review.
Genomic correlates of response to immune checkpoint blockade. Tanya E Keenan, Kelly P Burke, Eliezer M Van Allen. Nat Med, 2019 Mar 08; 25(3). PMID: 30842677 Free PMC article. Highly Cited. Review.
PD-1 and PD-L1 in cancer immunotherapy: clinical implications and future considerations. Yongshuai Jiang, Ming Chen, Hong Nie, Yuanyang Yuan. Hum Vaccin Immunother, 2019 Mar 20; 15(5). PMID: 30888929 Free PMC article. Review.
Predicting response to cancer immunotherapy using noninvasive radiomic biomarkers. S Trebeschi, S G Drago, +15 authors, H J W L Aerts. less Ann Oncol, 2019 Mar 22; 30(6). PMID: 30895304 Free PMC article. Highly Cited.
PD-L1 expression and tumor mutational burden are independent biomarkers in most cancers. Mark Yarchoan, Lee A Albacker, +8 authors, Elizabeth M Jaffee. less JCI Insight, 2019 Mar 22; 4(6). PMID: 30895946 Free PMC article. Highly Cited.
Use of targeted next generation sequencing to characterize tumor mutational burden and efficacy of immune checkpoint inhibition in small cell lung cancer. Biagio Ricciuti, Sasha Kravets, +7 authors, Mark M Awad. less J Immunother Cancer, 2019 Mar 30; 7(1). PMID: 30922388 Free PMC article.
Could the menagerie of the gut microbiome really cure cancer? Hope or hype. Muhammad Bilal Abid. J Immunother Cancer, 2019 Apr 04; 7(1). PMID: 30940203 Free PMC article.
Detection of Solid Tumor Molecular Residual Disease (MRD) Using Circulating Tumor DNA (ctDNA). Re-I Chin, Kevin Chen, +6 authors, Aadel A Chaudhuri. less Mol Diagn Ther, 2019 Apr 04; 23(3). PMID: 30941670 Free PMC article. Review.
Combination regimens with PD-1/PD-L1 immune checkpoint inhibitors for gastrointestinal malignancies. Dongxu Wang, Jianzhen Lin, +7 authors, Haitao Zhao. less J Hematol Oncol, 2019 Apr 25; 12(1). PMID: 31014381 Free PMC article. Review.
Treatment-Related Adverse Events of PD-1 and PD-L1 Inhibitors in Clinical Trials: A Systematic Review and Meta-analysis. Yucai Wang, Shouhao Zhou, +16 authors, Michael L Wang. less JAMA Oncol, 2019 Apr 26; 5(7). PMID: 31021376 Free PMC article. Highly Cited. Systematic Review.
Emerging therapies for non-small cell lung cancer. Chao Zhang, Natasha B Leighl, Yi-Long Wu, Wen-Zhao Zhong. J Hematol Oncol, 2019 Apr 27; 12(1). PMID: 31023335 Free PMC article. Highly Cited. Review.
Automated image analysis of NSCLC biopsies to predict response to anti-PD-L1 therapy. Sonja Althammer, Tze Heng Tan, +14 authors, Keith E Steele. less J Immunother Cancer, 2019 May 08; 7(1). PMID: 31060602 Free PMC article.
Recent advances in triple negative breast cancer: the immunotherapy era. Antonio Marra, Giulia Viale, Giuseppe Curigliano. BMC Med, 2019 May 10; 17(1). PMID: 31068190 Free PMC article. Highly Cited. Review.
The great debate at "Melanoma Bridge 2018", Naples, December 1st, 2018. Paolo A Ascierto, Paolo Bruzzi, +7 authors, Francesco Perrone. less J Transl Med, 2019 May 12; 17(1). PMID: 31077205 Free PMC article.
EGFR mutation subtypes and response to immune checkpoint blockade treatment in non-small-cell lung cancer. K Hastings, H A Yu, +28 authors, K Politi. less Ann Oncol, 2019 May 16; 30(8). PMID: 31086949 Free PMC article. Highly Cited.
Paired whole exome and transcriptome analyses for the Immunogenomic changes during concurrent chemoradiotherapy in esophageal squamous cell carcinoma. Sehhoon Park, Je-Gun Joung, +10 authors, Jong-Mu Sun. less J Immunother Cancer, 2019 May 18; 7(1). PMID: 31097034 Free PMC article.
Toward a comprehensive view of cancer immune responsiveness: a synopsis from the SITC workshop. Davide Bedognetti, Michele Ceccarelli, +53 authors, Society for Immunotherapy of Cancer (SITC) Cancer Immune Responsiveness Task Force and Working Groups. less J Immunother Cancer, 2019 May 23; 7(1). PMID: 31113486 Free PMC article. Review.
Tumor Characteristics Associated with Benefit from Pembrolizumab in Advanced Non-Small Cell Lung Cancer. Siwen Hu-Lieskovan, Aaron Lisberg, +16 authors, Edward B Garon. less Clin Cancer Res, 2019 May 23; 25(16). PMID: 31113840 Free PMC article.
Prognostic value of TIM-1 expression in human non-small-cell lung cancer. Xiao Zheng, Kai Xu, +2 authors, Lujun Chen, You Zhou, Jingting Jiang. less J Transl Med, 2019 May 30; 17(1). PMID: 31138322 Free PMC article.
The appropriate frequency and function of decidual Tim-3+CTLA-4+CD8+ T cells are important in maintaining normal pregnancy. Songcun Wang, Fengrun Sun, +7 authors, Meirong Du. less Cell Death Dis, 2019 May 30; 10(6). PMID: 31138782 Free PMC article.
Mismatch repair deficiency/microsatellite instability-high as a predictor for anti-PD-1/PD-L1 immunotherapy efficacy. Pengfei Zhao, Li Li, Xiaoyue Jiang, Qin Li. J Hematol Oncol, 2019 Jun 04; 12(1). PMID: 31151482 Free PMC article. Highly Cited. Review.
Association between peripheral blood markers and immune-related factors on tumor cells in patients with resected primary lung adenocarcinoma. Kazuki Takada, Mototsugu Shimokawa, +8 authors, Masaki Mori. less PLoS One, 2019 Jun 05; 14(6). PMID: 31163080 Free PMC article.
Patients Selection for Immunotherapy in Solid Tumors: Overcome the Naïve Vision of a Single Biomarker. Diego Signorelli, Patrizia Giannatempo, +11 authors, Immune-Oncology YOUNG Group. less Biomed Res Int, 2019 Jun 11; 2019. PMID: 31179334 Free PMC article. Review.
A Computational Model of Neoadjuvant PD-1 Inhibition in Non-Small Cell Lung Cancer. Mohammad Jafarnejad, Chang Gong, +6 authors, Aleksander S Popel. less AAPS J, 2019 Jun 27; 21(5). PMID: 31236847 Free PMC article.
Bioinformatic Methods and Bridging of Assay Results for Reliable Tumor Mutational Burden Assessment in Non-Small-Cell Lung Cancer. Han Chang, Ariella Sasson, +7 authors, Joseph Szustakowski. less Mol Diagn Ther, 2019 Jun 30; 23(4). PMID: 31250328 Free PMC article.
Potential immune escape mechanisms underlying the distinct clinical outcome of immune checkpoint blockades in small cell lung cancer. Yaru Tian, Xiaoyang Zhai, +2 authors, Anqin Han, Hui Zhu, Jinming Yu. less J Hematol Oncol, 2019 Jun 30; 12(1). PMID: 31253167 Free PMC article. Review.
Determinants of immunological evasion and immunocheckpoint inhibition response in non-small cell lung cancer: the genetic front. Maria Saigi, Juan J Alburquerque-Bejar, Montse Sanchez-Cespedes. Oncogene, 2019 Jun 30; 38(31). PMID: 31253869 Review.
Genomic landscape and its correlations with tumor mutational burden, PD-L1 expression, and immune cells infiltration in Chinese lung squamous cell carcinoma. Tao Jiang, Jinpeng Shi, +13 authors, Caicun Zhou. less J Hematol Oncol, 2019 Jul 14; 12(1). PMID: 31299995 Free PMC article.
Heterogeneity of PD-L1 expression in non-small cell lung cancer: Implications for specimen sampling in predicting treatment response. Alexander Haragan, John K Field, +3 authors, John R Gosney. less Lung Cancer, 2019 Jul 20; 134. PMID: 31320000 Free PMC article.
Phase I Trial of Targeted EGFR or ALK Therapy with Ipilimumab in Metastatic NSCLC with Long-Term Follow-Up. Anna W Chalmers, Shiven Patel, +6 authors, Wallace Akerley. less Target Oncol, 2019 Jul 28; 14(4). PMID: 31346927
Designing gene panels for tumor mutational burden estimation: the need to shift from 'correlation' to 'accuracy'. Hao-Xiang Wu, Zi-Xian Wang, +2 authors, Qi Zhao, Feng Wang, Rui-Hua Xu. less J Immunother Cancer, 2019 Aug 08; 7(1). PMID: 31387639 Free PMC article.
Comparisons between tumor burden and other prognostic factors that influence survival of patients with non-small cell lung cancer treated with immune checkpoint inhibitors. Yoshihiko Sakata, Kodai Kawamura, +9 authors, Takuro Sakagami. less Thorac Cancer, 2019 Nov 05; 10(12). PMID: 31679185 Free PMC article.
Identifying successful biomarkers for patients with non-small-cell lung cancer. Alex Friedlaender, Joshua Bauml, Giuseppe Luigi Banna, Alfredo Addeo. Lung Cancer Manag, 2019 Dec 07; 8(3). PMID: 31807145 Free PMC article.
Immunosurveillance and Immunoediting of Lung Cancer: Current Perspectives and Challenges. Kei Kunimasa, Taichiro Goto. Int J Mol Sci, 2020 Jan 23; 21(2). PMID: 31963413 Free PMC article. Review.
DNAH10 mutation correlates with cisplatin sensitivity and tumor mutation burden in small-cell lung cancer. Man Li, Anqi Lin, +5 authors, Linlang Guo. less Aging (Albany NY), 2020 Jan 22; 12(2). PMID: 31959735 Free PMC article.
T-Cell Immunotherapies Targeting Histocompatibility and Tumor Antigens in Hematological Malignancies. Valérie Janelle, Caroline Rulleau, +2 authors, Simon Del Testa, Cédric Carli, Jean-Sébastien Delisle. less Front Immunol, 2020 Mar 11; 11. PMID: 32153583 Free PMC article. Review.
Use of Programmed Death Receptor-1 and/or Programmed Death Ligand 1 Inhibitors for the Treatment of Brain Metastasis of Lung Cancer. Shiqiang Wang, Chongling Hu, Fei Xie, Yanhui Liu. Onco Targets Ther, 2020 Mar 12; 13. PMID: 32158220 Free PMC article. Review.
Combination checkpoint inhibitors for treatment of non-small-cell lung cancer: an update on dual anti-CTLA-4 and anti-PD-1/PD-L1 therapies. Sonam Puri, Michael Shafique. Drugs Context, 2020 Mar 12; 9. PMID: 32158484 Free PMC article. Review.
Immunotherapy for Non-small Cell Lung Cancer: Current Landscape and Future Perspectives. Sun Min Lim, Min Hee Hong, Hye Ryun Kim. Immune Netw, 2020 Mar 12; 20(1). PMID: 32158598 Free PMC article. Review.
[Advances in Combination Therapy of Immune Checkpoint Inhibitors for Lung Cancer]. Hanfei Guo, Rilan Bai, Jiuwei Cui. Zhongguo Fei Ai Za Zhi, 2020 Feb 26; 23(2). PMID: 32093454 Free PMC article. Review.
Mechanism- and Immune Landscape-Based Ranking of Therapeutic Responsiveness of 22 Major Human Cancers to Next Generation Anti-CTLA-4 Antibodies. Peng Zhang, Xinxin Xiong, +8 authors, Pan Zheng. less Cancers (Basel), 2020 Jan 30; 12(2). PMID: 31991588 Free PMC article.
The Inflammatory Milieu of Adamantinomatous Craniopharyngioma and Its Implications for Treatment. Ros Whelan, Eric Prince, Ahmed Gilani, Todd Hankinson. J Clin Med, 2020 Feb 23; 9(2). PMID: 32075140 Free PMC article. Review.
Analysis of immune-related signatures of lung adenocarcinoma identified two distinct subtypes: implications for immune checkpoint blockade therapy. Qinghua Wang, Meiling Li, +5 authors, Kexin Chen. less Aging (Albany NY), 2020 Feb 25; 12(4). PMID: 32091408 Free PMC article.
Association Between Skin Reaction and Clinical Benefit in Patients Treated with Anti-Programmed Cell Death 1 Monotherapy for Advanced Non-Small Cell Lung Cancer. Mari Aso, Yukihiro Toi, +15 authors, Shunichi Sugawara. less Oncologist, 2020 Mar 13; 25(3). PMID: 32162801 Free PMC article.
Gastrointestinal and Hepatic Complications of Immunotherapy: Current Management and Future Perspectives. Michael Dougan. Curr Gastroenterol Rep, 2020 Mar 19; 22(4). PMID: 32185493 Review.
PD-L1 Testing in Non-small Cell Lung Cancer: Past, Present, and Future. Hyojin Kim, Jin-Haeng Chung. J Pathol Transl Med, 2019 May 03; 53(4). PMID: 31042863 Free PMC article. Review.
Antitumor activity of an engineered decoy receptor targeting CLCF1-CNTFR signaling in lung adenocarcinoma. Jun W Kim, Cesar P Marquez, +13 authors, E Alejandro Sweet-Cordero. less Nat Med, 2019 Nov 09; 25(11). PMID: 31700175 Free PMC article.
Advances in the Diagnosis and Management of Well-Differentiated Neuroendocrine Neoplasms. Johannes Hofland, Gregory Kaltsas, Wouter W de Herder. Endocr Rev, 2019 Sep 27; 41(2). PMID: 31555796 Free PMC article. Review.
First-Line Nivolumab Plus Ipilimumab in Advanced Non-Small-Cell Lung Cancer (CheckMate 568): Outcomes by Programmed Death Ligand 1 and Tumor Mutational Burden as Biomarkers. Neal Ready, Matthew D Hellmann, +25 authors, Suresh S Ramalingam. less J Clin Oncol, 2019 Feb 21; 37(12). PMID: 30785829 Free PMC article. Highly Cited.
Consensus guidelines for the definition, detection and interpretation of immunogenic cell death. Lorenzo Galluzzi, Ilio Vitale, +51 authors, Francesco M Marincola. less J Immunother Cancer, 2020 Mar 27; 8(1). PMID: 32209603 Free PMC article. Review.
The prognostic value of tumor mutational burden and immune cell infiltration in esophageal cancer patients with or without radiotherapy. Cheng Yuan, Liyang Xiang, +8 authors, Conghua Xie. less Aging (Albany NY), 2020 Mar 14; 12(5). PMID: 32165590 Free PMC article.
Impact of panel design and cut-off on tumour mutational burden assessment in metastatic solid tumour samples. Joanne M Mankor, Marthe S Paats, +7 authors, Martijn P J K Lolkema. less Br J Cancer, 2020 Feb 26; 122(7). PMID: 32094484 Free PMC article.
Emerging Treatments for Malignant Pleural Mesothelioma: Where Are We Heading? Luca Cantini, Raffit Hassan, Daniel H Sterman, Joachim G J V Aerts. Front Oncol, 2020 Apr 01; 10. PMID: 32226777 Free PMC article. Review.
Personal tumor antigens in blood malignancies: genomics-directed identification and targeting. Livius Penter, Catherine J Wu. J Clin Invest, 2020 Jan 28; 130(4). PMID: 31985488 Free PMC article. Review.
Effect of sex on the efficacy of patients receiving immune checkpoint inhibitors in advanced non-small cell lung cancer. Chengdi Wang, Wenliang Qiao, +5 authors, Weimin Li. less Cancer Med, 2019 Jun 06; 8(8). PMID: 31165589 Free PMC article.
High Yield of RNA Sequencing for Targetable Kinase Fusions in Lung Adenocarcinomas with No Mitogenic Driver Alteration Detected by DNA Sequencing and Low Tumor Mutation Burden. Ryma Benayed, Michael Offin, +16 authors, Marc Ladanyi. less Clin Cancer Res, 2019 Apr 28; 25(15). PMID: 31028088 Free PMC article. Highly Cited.
Treatment options beyond immunotherapy in patients with wild-type lung adenocarcinoma: a Delphi consensus. D Isla, J de Castro, +5 authors, J M Trigo. less Clin Transl Oncol, 2019 Aug 02; 22(5). PMID: 31368078
How Can Immune Checkpoint Inhibitors Cause Hyperprogression in Solid Tumors? Morgane Denis, Michael Duruisseaux, Marie Brevet, Charles Dumontet. Front Immunol, 2020 Apr 09; 11. PMID: 32265935 Free PMC article. Review.
Immunotherapy: From Advanced NSCLC to Early Stages, an Evolving Concept. Thierry Berghmans, Valérie Durieux, Lizza E L Hendriks, Anne-Marie Dingemans. Front Med (Lausanne), 2020 Apr 09; 7. PMID: 32266275 Free PMC article. Systematic Review.
Comprehensive routine diagnostic screening to identify predictive mutations, gene amplifications, and microsatellite instability in FFPE tumor material. Elisabeth M P Steeghs, Leonie I Kroeze, +10 authors, Astrid Eijkelenboom. less BMC Cancer, 2020 Apr 09; 20(1). PMID: 32264863 Free PMC article.
FcγR-Binding Is an Important Functional Attribute for Immune Checkpoint Antibodies in Cancer Immunotherapy. Xin Chen, Xiaomin Song, Kang Li, Tong Zhang. Front Immunol, 2019 Mar 14; 10. PMID: 30863404 Free PMC article. Highly Cited. Review.
Durvalumab With or Without Tremelimumab vs Standard Chemotherapy in First-line Treatment of Metastatic Non-Small Cell Lung Cancer: The MYSTIC Phase 3 Randomized Clinical Trial. Naiyer A Rizvi, Byoung Chul Cho, +28 authors, MYSTIC Investigators. less JAMA Oncol, 2020 Apr 10; 6(5). PMID: 32271377 Free PMC article.
Mutation-Derived Neoantigens for Cancer Immunotherapy. John C Castle, Mohamed Uduman, +2 authors, Simarjot Pabla, Robert B Stein, Jennifer S Buell. less Front Immunol, 2019 Aug 24; 10. PMID: 31440245 Free PMC article.
Feasibility and utility of a panel testing for 114 cancer-associated genes in a clinical setting: A hospital-based study. Kuniko Sunami, Hitoshi Ichikawa, +37 authors, Takashi Kohno. less Cancer Sci, 2019 Feb 12; 110(4). PMID: 30742731 Free PMC article.
Screening common signaling pathways associated with drug resistance in non-small cell lung cancer via gene expression profile analysis. Ting Sun, Qitai Zhao, +9 authors, Yi Zhang. less Cancer Med, 2019 Apr 27; 8(6). PMID: 31025554 Free PMC article.
Rational application of the first-line chemotherapy and immune checkpoint inhibitors in advanced nonsmall cell lung cancer: A meta-analysis. Rui Cao, Jie-Tao Ma, +6 authors, Cheng-Bo Han. less Cancer Med, 2019 Jul 13; 8(11). PMID: 31297962 Free PMC article.
Effective effectors: How T cells access and infiltrate the central nervous system. Kendra L Congdon, Luis A Sanchez-Perez, John H Sampson. Pharmacol Ther, 2018 Dec 18; 197. PMID: 30557632 Free PMC article. Review.
Breast cancer immunology and immunotherapy: targeting the programmed cell death protein-1/programmed cell death protein ligand-1. Jing Zhao, Jian Huang. Chin Med J (Engl), 2020 Feb 28; 133(7). PMID: 32106121 Free PMC article. Review.
Small lung tumor biopsy samples are feasible for high quality targeted next generation sequencing. Hidenori Kage, Shinji Kohsaka, +10 authors, Takahide Nagase. less Cancer Sci, 2019 Jun 22; 110(8). PMID: 31222846 Free PMC article.
Recent Advances in Lung Cancer Immunotherapy: Input of T-Cell Epitopes Associated With Impaired Peptide Processing. Marine Leclerc, Laura Mezquita, +4 authors, Fathia Mami-Chouaib. less Front Immunol, 2019 Jul 25; 10. PMID: 31333652 Free PMC article. Review.
Radiation unlocks the therapeutic potential of immune checkpoint blockers in lung cancer patients. Eric C Ko, Lorenzo Galluzzi. Oncoimmunology, 2019 Aug 16; 8(8). PMID: 31413913 Free PMC article.
Gene signatures of tumor inflammation and epithelial-to-mesenchymal transition (EMT) predict responses to immune checkpoint blockade in lung cancer with high accuracy. Jeffrey C Thompson, Wei-Ting Hwang, +9 authors, Steven M Albelda. less Lung Cancer, 2019 Nov 05; 139. PMID: 31683225 Free PMC article.
Association of survival and genomic mutation signature with immunotherapy in patients with hepatocellular carcinoma. Qiyun Ou, Yunfang Yu, +11 authors, Baoming Luo. less Ann Transl Med, 2020 Apr 21; 8(5). PMID: 32309377 Free PMC article.
Identifying optimal first-line interventions for advanced non-small cell lung carcinoma according to PD-L1 expression: a systematic review and network meta-analysis. Jie Liu, Chengming Li, +2 authors, Samuel Seery, Jinming Yu, Xue Meng. less Oncoimmunology, 2020 Apr 22; 9(1). PMID: 32313723 Free PMC article. Systematic Review.
PD/1-PD-Ls Checkpoint: Insight on the Potential Role of NK Cells. Silvia Pesce, Marco Greppi, +5 authors, Emanuela Marcenaro. less Front Immunol, 2019 Jun 20; 10. PMID: 31214193 Free PMC article. Highly Cited. Review.
Establishing guidelines to harmonize tumor mutational burden (TMB): in silico assessment of variation in TMB quantification across diagnostic platforms: phase I of the Friends of Cancer Research TMB Harmonization Project. Diana M Merino, Lisa M McShane, +31 authors, TMB Harmonization Consortium. less J Immunother Cancer, 2020 Mar 29; 8(1). PMID: 32217756 Free PMC article.
Comparison of commonly used solid tumor targeted gene sequencing panels for estimating tumor mutation burden shows analytical and prognostic concordance within the cancer genome atlas cohort. Nicholas Bevins, Shulei Sun, +2 authors, Zied Gaieb, John A Thorson, Sarah S Murray. less J Immunother Cancer, 2020 Mar 29; 8(1). PMID: 32217764 Free PMC article.
When to Consider Immune Checkpoint Inhibitors in Oncogene-Driven Non-Small Cell Lung Cancer? Laurent Mhanna, Nicolas Guibert, Julie Milia, Julien Mazieres. Curr Treat Options Oncol, 2019 Jun 07; 20(7). PMID: 31172347 Free PMC article. Review.
Programmed cell death ligand 1 expression in cytologic and surgical non-small cell lung carcinoma specimens from a single institution: Association with clinicopathologic features and molecular alterations. Ping Mei, Konstantin Shilo, +3 authors, Lai Wei, Rulong Shen, Dena Tonkovich, Zaibo Li. less Cancer Cytopathol, 2019 Apr 27; 127(7). PMID: 31025831 Free PMC article.
Comparison of a combination of chemotherapy and immune checkpoint inhibitors and immune checkpoint inhibitors alone for the treatment of advanced and metastatic non-small cell lung cancer. Chih-Hsi Scott Kuo, Chin-Chou Wang, +8 authors, Cheng-Ta Yang. less Thorac Cancer, 2019 Apr 06; 10(5). PMID: 30950239 Free PMC article.
Molecular characterization of clinical responses to PD-1/PD-L1 inhibitors in non-small cell lung cancer: Predictive value of multidimensional immunomarker detection for the efficacy of PD-1 inhibitors in Chinese patients. Peng Song, Xiaoxia Cui, +14 authors, Li Zhang. less Thorac Cancer, 2019 Apr 25; 10(5). PMID: 31016875 Free PMC article.
Homologous recombination and DNA repair mutations in patients treated with carboplatin and nab-paclitaxel for metastatic non-small cell lung cancer. Dwight H Owen, Terence M Williams, +7 authors, Gregory A Otterson. less Lung Cancer, 2019 Jul 20; 134. PMID: 31319977 Free PMC article.
Immune-based therapies for hepatocellular carcinoma. David J Pinato, Nadia Guerra, +8 authors, Lorenza Rimassa. less Oncogene, 2020 Mar 12; 39(18). PMID: 32157213 Free PMC article. Review.
Circulating tumor cells in advanced non-small cell lung cancer patients are associated with worse tumor response to checkpoint inhibitors. Menno Tamminga, Sanne de Wit, +4 authors, Harry J M Groen. less J Immunother Cancer, 2019 Jul 12; 7(1). PMID: 31291995 Free PMC article.
Tumor mutational burden quantification from targeted gene panels: major advancements and challenges. Laura Fancello, Sara Gandini, Pier Giuseppe Pelicci, Luca Mazzarella. J Immunother Cancer, 2019 Jul 17; 7(1). PMID: 31307554 Free PMC article. Review.
Discontinuation due to immune-related adverse events is a possible predictive factor for immune checkpoint inhibitors in patients with non-small cell lung cancer. Kazutoshi Komiya, Tomomi Nakamura, +5 authors, Naoko Sueoka-Aragane. less Thorac Cancer, 2019 Jul 23; 10(9). PMID: 31328416 Free PMC article.
First-in-human phase 1 study of IT1208, a defucosylated humanized anti-CD4 depleting antibody, in patients with advanced solid tumors. Kohei Shitara, Satoshi Ueha, +18 authors, Toshihiko Doi. less J Immunother Cancer, 2019 Jul 26; 7(1). PMID: 31340866 Free PMC article.
Immunotherapy in small-cell lung cancer: from molecular promises to clinical challenges. A Pavan, I Attili, +3 authors, G Pasello, V Guarneri, P F Conte, L Bonanno. less J Immunother Cancer, 2019 Aug 07; 7(1). PMID: 31383005 Free PMC article. Review.
Current issues and perspectives in PD-1 blockade cancer immunotherapy. Kenji Chamoto, Ryusuke Hatae, Tasuku Honjo. Int J Clin Oncol, 2020 Jan 05; 25(5). PMID: 31900651 Free PMC article. Review.
STING Pathway Expression Identifies NSCLC With an Immune-Responsive Phenotype. Carminia M Della Corte, Triparna Sen, +21 authors, Lauren A Byers. less J Thorac Oncol, 2020 Feb 19; 15(5). PMID: 32068166 Free PMC article.
STK11 and KEAP1 mutations as prognostic biomarkers in an observational real-world lung adenocarcinoma cohort. Simon Papillon-Cavanagh, Parul Doshi, +2 authors, Radu Dobrin, Joseph Szustakowski, Alice M Walsh. less ESMO Open, 2020 Apr 22; 5(2). PMID: 32312757 Free PMC article.
Recurrent Metastatic Penile Cancer Patient with Positive PD-L1 Expression Obtained Significant Benefit from Immunotherapy: A Case Report and Literature Review. Xiangyu Su, Jing Zhang, +2 authors, Chenchun Fu, Mingzhe Xiao, Cailian Wang. less Onco Targets Ther, 2020 May 06; 13. PMID: 32368090 Free PMC article.
Immuno-oncology-the new paradigm of lung cancer treatment. D E Dawe, C H Harlos, R A Juergens. Curr Oncol, 2020 May 06; 27(Suppl 2). PMID: 32368177 Free PMC article. Review.
Preserving the CTLA-4 Checkpoint for Safer and More Effective Cancer Immunotherapy. Yang Liu, Pan Zheng. Trends Pharmacol Sci, 2019 Dec 15; 41(1). PMID: 31836191 Free PMC article. Review.
Characterization of tumor mutation burden, PD-L1 and DNA repair genes to assess relationship to immune checkpoint inhibitors response in metastatic renal cell carcinoma. Matthew Kyle Labriola, Jason Zhu, +9 authors, Tian Zhang. less J Immunother Cancer, 2020 Mar 30; 8(1). PMID: 32221016 Free PMC article.
Cancer cell-intrinsic expression of MHC II in lung cancer cell lines is actively restricted by MEK/ERK signaling and epigenetic mechanisms. Alexander J Neuwelt, Abigail K Kimball, +11 authors, Eric T Clambey. less J Immunother Cancer, 2020 Apr 22; 8(1). PMID: 32312906 Free PMC article.
Effect of Combined Immune Checkpoint Inhibition vs Best Supportive Care Alone in Patients With Advanced Colorectal Cancer: The Canadian Cancer Trials Group CO.26 Study. Eric X Chen, Derek J Jonker, +18 authors, Chris J O'Callaghan. less JAMA Oncol, 2020 May 08; 6(6). PMID: 32379280 Free PMC article.
Neoadjuvant immunotherapy with resectable non-small cell lung cancer: recent advances and future challenges. Sijia Ren, Chunguo Wang, Jianfei Shen, Chengchu Zhu. J Thorac Dis, 2020 May 13; 12(4). PMID: 32395299 Free PMC article.
Novel tumor mutation score versus tumor mutation burden in predicting survival after immunotherapy in pan-cancer patients from the MSK-IMPACT cohort. Yuan Li, Zuhua Chen, Long Wu, Weiping Tao. Ann Transl Med, 2020 May 13; 8(7). PMID: 32395490 Free PMC article.
Overcoming resistance to anti-PD1 and anti-PD-L1 treatment in gastrointestinal malignancies. Alberto Puccini, Francesca Battaglin, +2 authors, Maria Laura Iaia, Heinz-Josef Lenz, Mohamed E Salem. less J Immunother Cancer, 2020 May 13; 8(1). PMID: 32393474 Free PMC article. Review.
Baseline Plasma Tumor Mutation Burden Predicts Response to Pembrolizumab-based Therapy in Patients with Metastatic Non-Small Cell Lung Cancer. Charu Aggarwal, Jeffrey C Thompson, +18 authors, Erica L Carpenter. less Clin Cancer Res, 2020 Feb 28; 26(10). PMID: 32102950 Free PMC article.
Contribution of Macrophages and T Cells in Skeletal Metastasis. Veronica Mendoza-Reinoso, Laurie K McCauley, Pierrick G J Fournier. Cancers (Basel), 2020 Apr 25; 12(4). PMID: 32326073 Free PMC article. Review.
High tumor mutation burden is associated with DNA damage repair gene mutation in breast carcinomas. Ping Mei, C Eric Freitag, +3 authors, Zaibo Li. less Diagn Pathol, 2020 May 13; 15(1). PMID: 32393302 Free PMC article.
Association of immune-related pneumonitis with the efficacy of PD-1/PD-L1 inhibitors in non-small cell lung cancer. Pengfei Cui, Di Huang, +9 authors, Yi Hu. less Ther Adv Med Oncol, 2020 May 20; 12. PMID: 32426052 Free PMC article.
RAD51B Levels as a Potential Predictive Biomarker for PD-1 Blockade Response in Non-Small Cell Lung Cancer. Inês Maria Guerreiro, Daniela Barros-Silva, +8 authors, Carmen Jerónimo. less J Clin Med, 2020 Apr 08; 9(4). PMID: 32252414 Free PMC article.
The emerging role of epigenetic therapeutics in immuno-oncology. Michael J Topper, Michelle Vaz, +2 authors, Kristen A Marrone, Julie R Brahmer, Stephen B Baylin. less Nat Rev Clin Oncol, 2019 Sep 25; 17(2). PMID: 31548600 Free PMC article. Review.
Randomized Phase II Trial of Nivolumab Versus Nivolumab and Ipilimumab for Recurrent or Persistent Ovarian Cancer: An NRG Oncology Study. Dmitriy Zamarin, Robert A Burger, +11 authors, Carol Aghajanian. less J Clin Oncol, 2020 Apr 11; 38(16). PMID: 32275468 Free PMC article.
Association of Survival and Immune-Related Biomarkers With Immunotherapy in Patients With Non-Small Cell Lung Cancer: A Meta-analysis and Individual Patient-Level Analysis. Yunfang Yu, Dongqiang Zeng, +8 authors, Herui Yao. less JAMA Netw Open, 2019 Jul 11; 2(7). PMID: 31290993 Free PMC article. Highly Cited.
Avelumab in patients with previously treated metastatic Merkel cell carcinoma: long-term data and biomarker analyses from the single-arm phase 2 JAVELIN Merkel 200 trial. Sandra P D'Angelo, Shailender Bhatia, +15 authors, Paul T Nghiem. less J Immunother Cancer, 2020 May 18; 8(1). PMID: 32414862 Free PMC article.
Bcl6 Preserves the Suppressive Function of Regulatory T Cells During Tumorigenesis. Yiding Li, Zhiming Wang, +16 authors, Lifan Xu. less Front Immunol, 2020 Jun 02; 11. PMID: 32477338 Free PMC article.
Tumor Mutational Burden and PTEN Alterations as Molecular Correlates of Response to PD-1/L1 Blockade in Metastatic Triple-Negative Breast Cancer. Romualdo Barroso-Sousa, Tanya E Keenan, +18 authors, Sara M Tolaney. less Clin Cancer Res, 2020 Feb 06; 26(11). PMID: 32019858 Free PMC article.
Inhibition of MICA and MICB Shedding Elicits NK-Cell-Mediated Immunity against Tumors Resistant to Cytotoxic T Cells. Lucas Ferrari de Andrade, Sushil Kumar, +6 authors, Kai W Wucherpfennig. less Cancer Immunol Res, 2020 Mar 27; 8(6). PMID: 32209637 Free PMC article.
Review of precision cancer medicine: Evolution of the treatment paradigm. Apostolia M Tsimberidou, Elena Fountzilas, Mina Nikanjam, Razelle Kurzrock. Cancer Treat Rev, 2020 Apr 07; 86. PMID: 32251926 Free PMC article. Review.
Canadian consensus: a new systemic treatment algorithm for advanced EGFR-mutated non-small-cell lung cancer. B Melosky, S Banerji, +5 authors, P Cheema. less Curr Oncol, 2020 Jun 04; 27(2). PMID: 32489263 Free PMC article.
Updated guidelines for predictive biomarker testing in advanced non-small-cell lung cancer: a National Consensus of the Spanish Society of Pathology and the Spanish Society of Medical Oncology. P Garrido, E Conde, +7 authors, F López-Ríos. less Clin Transl Oncol, 2019 Oct 11; 22(7). PMID: 31598903 Free PMC article.
Mismatch repair deficiency in metastatic prostate cancer: Response to PD-1 blockade and standard therapies. Laura S Graham, Bruce Montgomery, +6 authors, Michael T Schweizer. less PLoS One, 2020 May 27; 15(5). PMID: 32453797 Free PMC article.
Current status and future perspectives of liquid biopsy in non-small cell lung cancer. Sunhee Chang, Jae Young Hur, +2 authors, Yoon-La Choi, Chang Hun Lee, Wan Seop Kim. less J Pathol Transl Med, 2020 May 29; 54(3). PMID: 32460474 Free PMC article. Review.
Combinatorial assessment of ctDNA release and mutational burden predicts anti-PD(L)1 therapy outcome in nonsmall-cell lung cancer. Wenfeng Fang, Yuxiang Ma, +11 authors, Li Zhang. less Clin Transl Med, 2020 Jun 09; 10(1). PMID: 32508057 Free PMC article.
Prediction of Benefit from Checkpoint Inhibitors in Mismatch Repair Deficient Metastatic Colorectal Cancer: Role of Tumor Infiltrating Lymphocytes. Fotios Loupakis, Ilaria Depetris, +23 authors, Matteo Fassan. less Oncologist, 2020 Jan 23; 25(6). PMID: 31967692 Free PMC article.
Uptake of positron emission tomography tracers reflects the tumor immune status in esophageal squamous cell carcinoma. Kengo Kuriyama, Tamami Higuchi, +13 authors, Hiroshi Saeki. less Cancer Sci, 2020 Apr 18; 111(6). PMID: 32302443 Free PMC article.
Precision Medicine for NSCLC in the Era of Immunotherapy: New Biomarkers to Select the Most Suitable Treatment or the Most Suitable Patient. Giovanni Rossi, Alessandro Russo, +13 authors, Carlo Genova. less Cancers (Basel), 2020 May 06; 12(5). PMID: 32365882 Free PMC article. Review.
Identification of PD1-mediated regulation of antitumor antigen response in patients with NSCLC using the trans vivo DTH assay. Diego A Lema, Ewa Jankowska-Gan, +2 authors, Nan Sethakorn, William Burlingham, Ticiana Leal. less J Immunother Cancer, 2020 Jun 13; 8(1). PMID: 32527929 Free PMC article.
Circulating Tumor DNA Analysis to Assess Risk of Progression after Long-term Response to PD-(L)1 Blockade in NSCLC. Matthew D Hellmann, Barzin Y Nabet, +32 authors, Maximilian Diehn. less Clin Cancer Res, 2020 Feb 13; 26(12). PMID: 32046999 Free PMC article.
Immune Checkpoint Inhibitors for Lung Cancer Treatment: A Review. Keisuke Onoi, Yusuke Chihara, +6 authors, Koichi Takayama. less J Clin Med, 2020 May 10; 9(5). PMID: 32384677 Free PMC article. Review.
Looking for the Optimal PD-1/PD-L1 Inhibitor in Cancer Treatment: A Comparison in Basic Structure, Function, and Clinical Practice. Yu Chen, Yanqing Pei, +3 authors, Xiangjiao Meng. less Front Immunol, 2020 Jun 18; 11. PMID: 32547566 Free PMC article. Review.
Non-Small Cell Lung Cancer Patient Preferences for First-Line Treatment: A Discrete Choice Experiment. Joanna P MacEwan, Komal Gupte-Singh, Lauren M Zhao, Karen L Reckamp. MDM Policy Pract, 2020 Jun 18; 5(1). PMID: 32548305 Free PMC article.
Analysis of immune-related signatures of colorectal cancer identifying two different immune phenotypes: Evidence for immune checkpoint inhibitor therapy. Gang Chen, Lin Wang, +3 authors, Tongwei Diao, Ying Chen, Chengbo Cao, Xindong Zhang. less Oncol Lett, 2020 Jun 23; 20(1). PMID: 32565977 Free PMC article.
Prognostic value of tumor mutation burden (TMB) and INDEL burden (IDB) in cancer: current view and clinical applications. Anwaar Saeed, Mohamed E Salem. Ann Transl Med, 2020 Jun 23; 8(9). PMID: 32566602 Free PMC article.
Heme oxygenase-1 orchestrates the immunosuppressive program of tumor-associated macrophages. Emmanuelle Alaluf, Benoît Vokaer, +8 authors, Stanislas Goriely. less JCI Insight, 2020 May 06; 5(11). PMID: 32369450 Free PMC article.
Higher Tumor Mutation Burden and Higher PD-L1 Activity Predicts the Efficacy of Immune Checkpoint Inhibitor Treatment in a Patient With Four Lung Cancers. A Case Report. Katsuo Usuda, Yo Niida, +5 authors, Hidetaka Uramoto. less Front Oncol, 2020 Jun 26; 10. PMID: 32582526 Free PMC article.
Immunophenotype and Response to Immunotherapy of RET-Rearranged Lung Cancers. Michael Offin, Robin Guo, +18 authors, Alexander Drilon. less JCO Precis Oncol, 2019 Jun 14; 3. PMID: 31192313 Free PMC article.
Primary Adrenal Insufficiency during Immune Checkpoint Inhibitor Treatment: Case Reports and Review of the Literature. Carlos Salinas, Alex Renner, +2 authors, Carlos Rojas, Suraj Samtani, Mauricio Burotto. less Case Rep Oncol, 2020 Jul 01; 13(2). PMID: 32595473 Free PMC article.
Brain immunology and immunotherapy in brain tumours. John H Sampson, Michael D Gunn, Peter E Fecci, David M Ashley. Nat Rev Cancer, 2019 Dec 07; 20(1). PMID: 31806885 Free PMC article. Review.
Sequential ctDNA whole-exome sequencing in advanced lung adenocarcinoma with initial durable tumor response on immune checkpoint inhibitor and late progression. Etienne Giroux Leprieur, Zofia Hélias-Rodzewicz, +10 authors, Jean-François Emile. less J Immunother Cancer, 2020 Jun 26; 8(1). PMID: 32581058 Free PMC article.
Tumor Mutational Burden and PD-L1 Expression in Non-Small-Cell Lung Cancer (NSCLC) in Southwestern China. Yuhui Ma, Quan Li, +10 authors, Yongchun Zhou. less Onco Targets Ther, 2020 Jul 02; 13. PMID: 32606739 Free PMC article.
Compromise or not? A case report of successful treatment of pembrolizumab-induced hepatitis in a patient with non-small cell lung cancer with low-dose methylprednisolone and bicyclol. Yan'e Liu, Jie Zhang, +3 authors, Zhongnan Yin, Xiang Zhu, Lixiang Xue, Baoshan Cao. less Thorac Cancer, 2020 May 08; 11(7). PMID: 32379397 Free PMC article.
Development and validation of a genomic mutation signature to predict response to PD-1 inhibitors in non-squamous NSCLC: a multicohort study Xue Bai, De-Hua Wu, +11 authors, Zhong-Yi Dong. less J Immunother Cancer, 2020 Jul 02; 8(1). PMID: 32606052 Free PMC article.
Role of DNA repair defects in predicting immunotherapy response. Jing Zhang, David J H Shih, Shiaw-Yih Lin. Biomark Res, 2020 Jul 03; 8. PMID: 32612833 Free PMC article. Review.
Proteome Instability Is a Therapeutic Vulnerability in Mismatch Repair-Deficient Cancer. Daniel J McGrail, Jeannine Garnett, +20 authors, Shiaw-Yih Lin. less Cancer Cell, 2020 Feb 29; 37(3). PMID: 32109374 Free PMC article.
Assessment of associations between clinical and immune microenvironmental factors and tumor mutation burden in resected nonsmall cell lung cancer by applying machine learning to whole-slide images. Akira Ono, Yukihiro Terada, +17 authors, Toshiaki Takahashi. less Cancer Med, 2020 May 14; 9(13). PMID: 32400056 Free PMC article.
ICON: a randomized phase IIb study evaluating immunogenic chemotherapy combined with ipilimumab and nivolumab in patients with metastatic hormone receptor positive breast cancer. J A Kyte, N K Andresen, +4 authors, B Naume. less J Transl Med, 2020 Jul 06; 18(1). PMID: 32620163 Free PMC article.
Mechanistic insight of predictive biomarkers for antitumor PD‑1/PD‑L1 blockade: A paradigm shift towards immunome evaluation (Review). Wenjie You, Bin Shang, +3 authors, Jian Sun, Xueqing Liu, Lili Su, Shujuan Jiang. less Oncol Rep, 2020 Jul 07; 44(2). PMID: 32627031 Free PMC article. Review.
Combined Anti-Cancer Strategies Based on Anti-Checkpoint Inhibitor Antibodies. Josée Golay, Alain E Andrea. Antibodies (Basel), 2020 May 24; 9(2). PMID: 32443877 Free PMC article. Review.
Predicting response to immunotherapy in advanced non-small-cell lung cancer using tumor mutational burden radiomic biomarker. Bingxi He, Di Dong, +8 authors, Chang Chen. less J Immunother Cancer, 2020 Jul 09; 8(2). PMID: 32636239 Free PMC article.
Tumor evolution in epidermal growth factor receptor mutated non-small cell lung cancer. Ana I Velazquez, Caroline E McCoach. J Thorac Dis, 2020 Jul 10; 12(5). PMID: 32642202 Free PMC article. Review.
Analysis of tumor mutational burden: correlation of five large gene panels with whole exome sequencing. Carina Heydt, Jan Rehker, +8 authors, Sabine Merkelbach-Bruse. less Sci Rep, 2020 Jul 11; 10(1). PMID: 32647293 Free PMC article.
The identification of a CD47-blocking "hotspot" and design of a CD47/PD-L1 dual-specific antibody with limited hemagglutination. Rui Shi, Yan Chai, +7 authors, Jinghua Yan. less Signal Transduct Target Ther, 2020 Apr 17; 5(1). PMID: 32296041 Free PMC article.
Integration of Tumor Mutation Burden and PD-L1 Testing in Routine Laboratory Diagnostics in Non-Small Cell Lung Cancer. Stefanie Schatz, Markus Falk, +12 authors, Lukas C Heukamp. less Cancers (Basel), 2020 Jul 01; 12(6). PMID: 32599951 Free PMC article.
Current challenges for assessing the long-term clinical benefit of cancer immunotherapy: a multi-stakeholder perspective. Casey Quinn, Louis P Garrison, +8 authors, Elise Wu. less J Immunother Cancer, 2020 Jul 15; 8(2). PMID: 32661115 Free PMC article.
Tumor mutation burden associated with miRNA-gene interaction outcome mediates the survival of patients with liver hepatocellular carcinoma. Qing-Jiang Yu, Yi-Zhi Liang, Xiao-Ping Mei, Tai-Yong Fang. EXCLI J, 2020 Jul 16; 19. PMID: 32665773 Free PMC article.
Resistance to immune checkpoint inhibitors in non-small cell lung cancer: biomarkers and therapeutic strategies. Robert J Walsh, Ross A Soo. Ther Adv Med Oncol, 2020 Jul 17; 12. PMID: 32670423 Free PMC article. Review.
Durvalumab With or Without Tremelimumab for Patients With Metastatic Pancreatic Ductal Adenocarcinoma: A Phase 2 Randomized Clinical Trial. Eileen M O'Reilly, Do-Youn Oh, +11 authors, Philip Agop Philip. less JAMA Oncol, 2019 Jul 19; 5(10). PMID: 31318392 Free PMC article. Highly Cited.
Lymphovascular Invasion Is Associated With Mutational Burden and PD-L1 in Resected Lung Cancer. Kyle G Mitchell, Marcelo V Negrao, +14 authors, Boris Sepesi. less Ann Thorac Surg, 2019 Sep 25; 109(2). PMID: 31550464 Free PMC article.
The prospect of combination therapy with immune checkpoint inhibitors and chemotherapy for squamous cell carcinoma of the lung. Yoshinobu Ichiki, Takashi Fukuyama, Kozo Nakanishi. Transl Lung Cancer Res, 2020 Jul 18; 9(3). PMID: 32676343 Free PMC article.
PD-L1-expression patterns in large-cell neuroendocrine carcinoma of the lung: potential implications for use of immunotherapy in these patients: the GFPC 03-2017 "EPNEC" study. Dominique Arpin, Marie-Christine Charpentier, +23 authors, Diane Damotte. less Ther Adv Med Oncol, 2020 Jul 21; 12. PMID: 32684990 Free PMC article.
Biomarkers for immune checkpoint inhibition in non-small cell lung cancer (NSCLC). J Nicholas Bodor, Yanis Boumber, Hossein Borghaei. Cancer, 2019 Nov 07; 126(2). PMID: 31691957 Free PMC article. Review.
Landscape of somatic single nucleotide variants and indels in colorectal cancer and impact on survival. Syed H Zaidi, Tabitha A Harrison, +73 authors, Ulrike Peters. less Nat Commun, 2020 Jul 21; 11(1). PMID: 32686686 Free PMC article.
Immune checkpoint inhibitors in esophagogastric adenocarcinoma: do the results justify the hype? Megan Greally, Geoffrey Y Ku. J Thorac Dis, 2019 Feb 13; 10(12). PMID: 30746176 Free PMC article.
Prognostic value of immune score in nasopharyngeal carcinoma using digital pathology. Ya-Qin Wang, Lei Chen, +15 authors, Jun Ma. less J Immunother Cancer, 2020 Jul 22; 8(2). PMID: 32690665 Free PMC article.
Monocyte-derived APCs are central to the response of PD1 checkpoint blockade and provide a therapeutic target for combination therapy. Sjoerd T T Schetters, Ernesto Rodriguez, +5 authors, Yvette Van Kooyk. less J Immunother Cancer, 2020 Jul 22; 8(2). PMID: 32690667 Free PMC article.
A Novel Paradigm Between Leukocytosis, G-CSF Secretion, Neutrophil-to-Lymphocyte Ratio, Myeloid-Derived Suppressor Cells, and Prognosis in Non-small Cell Lung Cancer. Montreh Tavakkoli, Cy R Wilkins, Jodi V Mones, Michael J Mauro. Front Oncol, 2019 May 14; 9. PMID: 31080780 Free PMC article.
Clinical and Recent Patents Applications of PD-1/PD-L1 Targeting Immunotherapy in Cancer Treatment-Current Progress, Strategy, and Future Perspective. Libin Guo, Ran Wei, Yao Lin, Hang Fai Kwok. Front Immunol, 2020 Aug 01; 11. PMID: 32733486 Free PMC article. Review.
Can Ipilimumab restore immune response in advanced NSCLC after progression on anti-PD-1/PD-L1 agents? Michal Sternschuss, Nir Peled, +6 authors, Alona Zer. less Thorac Cancer, 2020 Jun 18; 11(8). PMID: 32548905 Free PMC article.
Choosing the best first-line therapy: NSCLC with no actionable oncogenic driver. So Yeon Kim, Balazs Halmos. Lung Cancer Manag, 2020 Aug 11; 9(3). PMID: 32774467 Free PMC article. Review.
Computed tomography texture analysis of response to second-line nivolumab in metastatic non-small cell lung cancer. Rahul Ladwa, Kate E Roberts, +3 authors, Kenneth Miles. less Lung Cancer Manag, 2020 Aug 11; 9(3). PMID: 32774469 Free PMC article.
Comparative risk of serious and fatal treatment-related adverse events caused by 19 immune checkpoint inhibitors used in cancer treatment: a network meta-analysis. Tingting Liu, Bo Jin, +4 authors, Guang Li. less Ther Adv Med Oncol, 2020 Aug 11; 12. PMID: 32774474 Free PMC article.
Somatic mutations in genes associated with mismatch repair predict survival in patients with metastatic cancer receiving immune checkpoint inhibitors. Yongping Liu, Lin Chen, +5 authors, Yang Ling. less Oncol Lett, 2020 Aug 11; 20(4). PMID: 32774500 Free PMC article.
The frequency and inter-relationship of PD-L1 expression and tumour mutational burden across multiple types of advanced solid tumours in China. Yanhui Chen, Yating Wang, +5 authors, Henghui Zhang. less Exp Hematol Oncol, 2020 Aug 11; 9. PMID: 32775040 Free PMC article.
Immunotherapies and Combination Strategies for Immuno-Oncology. Cody Barbari, Tyler Fontaine, +4 authors, Rahul R Deshmukh. less Int J Mol Sci, 2020 Jul 19; 21(14). PMID: 32679922 Free PMC article. Review.
Association of tumour and stroma PD-1, PD-L1, CD3, CD4 and CD8 expression with DCB and OS to nivolumab treatment in NSCLC patients pre-treated with chemotherapy. Anna-Larissa Nadia Niemeijer, Sara Sahba, +3 authors, Erik Thunnissen. less Br J Cancer, 2020 May 21; 123(3). PMID: 32433601 Free PMC article.
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Epigenetic Mechanisms of Resistance to Immune Checkpoint Inhibitors. Alexandre Perrier, Audrey Didelot, +2 authors, Pierre Laurent-Puig, Hélène Blons, Simon Garinet. less Biomolecules, 2020 Jul 28; 10(7). PMID: 32708698 Free PMC article. Review.
Escape from nonsense-mediated decay associates with anti-tumor immunogenicity. Kevin Litchfield, James L Reading, +17 authors, Charles Swanton. less Nat Commun, 2020 Aug 01; 11(1). PMID: 32733040 Free PMC article.
Tumor mutation burden in Chinese cancer patients and the underlying driving pathways of high tumor mutation burden across different cancer types. Xiao-Dong Jiao, Xiao-Chun Zhang, +16 authors, Yuan-Sheng Zang. less Ann Transl Med, 2020 Aug 15; 8(14). PMID: 32793704 Free PMC article.
Immune Checkpoint Inhibitors for Brain Metastases: A Primer for Neurosurgeons. Elisa Aquilanti, Priscilla K Brastianos. Neurosurgery, 2020 Apr 18; 87(3). PMID: 32302389 Free PMC article. Review.
The history and advances in cancer immunotherapy: understanding the characteristics of tumor-infiltrating immune cells and their therapeutic implications. Yuanyuan Zhang, Zemin Zhang. Cell Mol Immunol, 2020 Jul 03; 17(8). PMID: 32612154 Free PMC article. Review.
Ipilimumab plus nivolumab and chemoradiotherapy followed by surgery in patients with resectable and borderline resectable T3-4N0-1 non-small cell lung cancer: the INCREASE trial. Chris Dickhoff, Suresh Senan, +13 authors, Idris Bahce. less BMC Cancer, 2020 Aug 17; 20(1). PMID: 32795284 Free PMC article.
Combination of Immune Checkpoint Inhibitors with Chemotherapy in Lung Cancer. Wei Liu, Lei Zhang, +6 authors, Jianhui Cai. less Onco Targets Ther, 2020 Aug 18; 13. PMID: 32801752 Free PMC article. Review.
Are there any ethnic differences in the efficacy and safety of immune checkpoint inhibitors for treatment of lung cancer? Jiyun Lee, Jong-Mu Sun, +3 authors, Myung-Ju Ahn. less J Thorac Dis, 2020 Aug 18; 12(7). PMID: 32802459 Free PMC article. Review.
Value of circular RNA 0007385 in disease monitoring and prognosis estimation in non-small-cell lung cancer patients. Yijian Lin, Weiming Su, Guocui Lan. J Clin Lab Anal, 2020 Jul 16; 34(8). PMID: 32666646 Free PMC article.
Tumor copy-number alterations predict response to immune-checkpoint-blockade in gastrointestinal cancer. Zhihao Lu, Huan Chen, +14 authors, Lin Shen. less J Immunother Cancer, 2020 Aug 15; 8(2). PMID: 32792358 Free PMC article.
Role of Telomeres and Telomeric Proteins in Human Malignancies and Their Therapeutic Potential. Stina George Fernandes, Rebecca Dsouza, +5 authors, Ekta Khattar. less Cancers (Basel), 2020 Jul 18; 12(7). PMID: 32674474 Free PMC article. Review.
Do Elderly Lung Cancer Patients Aged ≥75 Years Benefit from Immune Checkpoint Inhibitors? Nagio Takigawa, Nobuaki Ochi, +7 authors, Hiromichi Yamane. less Cancers (Basel), 2020 Jul 28; 12(7). PMID: 32708291 Free PMC article. Review.
The Value of PD-L1 Expression as Predictive Biomarker in Metastatic Renal Cell Carcinoma Patients: A Meta-Analysis of Randomized Clinical Trials. Alberto Carretero-González, David Lora, +6 authors, Guillermo de Velasco. less Cancers (Basel), 2020 Jul 28; 12(7). PMID: 32709062 Free PMC article. Review.
Progress in Neoantigen Targeted Cancer Immunotherapies. Xue-Jiao Han, Xue-Lei Ma, +3 authors, Li Yang, Yu-Quan Wei, Yong Peng, Xia-Wei Wei. less Front Cell Dev Biol, 2020 Aug 28; 8. PMID: 32850843 Free PMC article. Review.
Immune checkpoint blockade in solid organ tumours: Choice, dose and predictors of response. Vishal Navani, Moira C Graves, Nikola A Bowden, Andre Van Der Westhuizen. Br J Clin Pharmacol, 2020 May 10; 86(9). PMID: 32384184 Free PMC article. Review.
Current status and future potential of predictive biomarkers for immune checkpoint inhibitors in gastric cancer. Byung Woog Kang, Ian Chau. ESMO Open, 2020 Aug 21; 5(4). PMID: 32817133 Free PMC article. Review.
Rational design of anti-GITR-based combination immunotherapy. Roberta Zappasodi, Cynthia Sirard, +16 authors, Taha Merghoub. less Nat Med, 2019 May 01; 25(5). PMID: 31036879 Free PMC article. Highly Cited.
CD47 prevents the elimination of diseased fibroblasts in scleroderma. Tristan Lerbs, Lu Cui, +7 authors, Gerlinde Wernig. less JCI Insight, 2020 Aug 21; 5(16). PMID: 32814713 Free PMC article.
Predictive biomarkers for cancer immunotherapy with immune checkpoint inhibitors. Rilan Bai, Zheng Lv, Dongsheng Xu, Jiuwei Cui. Biomark Res, 2020 Aug 31; 8. PMID: 32864131 Free PMC article. Review.
[Predictive Value of Tumor Mutation Burden in Immunotherapy for Lung Cancer]. Huanlan Sa, Kewei Ma, Yong Gao, Deqiang Wang. Zhongguo Fei Ai Za Zhi, 2019 Jun 15; 22(6). PMID: 31196372 Free PMC article. Review.
[Progress in Clinical Researches of PD-1/PD-L1 Checkpoint Inhibitor for Non-small Cell Lung Cancer]. Sixuan Wu, Chunhong Hu, +2 authors, Fang Wu, Yuanqiang Wu, Ping Liu. less Zhongguo Fei Ai Za Zhi, 2019 Jul 19; 22(7). PMID: 31315783 Free PMC article. Review.
Prognostic Value of Immune Environment Analysis in Small Bowel Adenocarcinomas with Verified Mutational Landscape and Predisposing Conditions. Erkki-Ville Wirta, Säde Szeto, +5 authors, Toni T Seppälä. less Cancers (Basel), 2020 Jul 29; 12(8). PMID: 32718028 Free PMC article.
Comprehensive molecular analyses of a TNF family-based signature with regard to prognosis, immune features, and biomarkers for immunotherapy in lung adenocarcinoma. Chaoqi Zhang, Guochao Zhang, +6 authors, Jie He. less EBioMedicine, 2020 Aug 28; 59. PMID: 32853987 Free PMC article.
Cancer-Specific Thresholds Adjust for Whole Exome Sequencing-based Tumor Mutational Burden Distribution. Evan M Fernandez, Kenneth Eng, +12 authors, Wei Song. less JCO Precis Oncol, 2019 Sep 03; 3. PMID: 31475242 Free PMC article.
Predictive Biomarkers of Response to Immunotherapy in Metastatic Renal Cell Cancer. Alessandra Raimondi, Pierangela Sepe, +7 authors, Giuseppe Procopio. less Front Oncol, 2020 Sep 10; 10. PMID: 32903369 Free PMC article. Review.
Absolute lymphocyte count as a prognostic biomarker for overall survival in patients with advanced melanoma treated with ipilimumab. Michael A Postow, Scott D Chasalow, +4 authors, Jedd D Wolchok. less Melanoma Res, 2019 Aug 20; 30(1). PMID: 31425479 Free PMC article.
Immune-related pneumonitis associated with immune checkpoint inhibitors in lung cancer: a network meta-analysis. Xinru Chen, Zhonghan Zhang, +10 authors, Li Zhang. less J Immunother Cancer, 2020 Aug 31; 8(2). PMID: 32863271 Free PMC article.
STK11 (LKB1) mutations in metastatic NSCLC: Prognostic value in the real world. Norah J Shire, Alyssa B Klein, +6 authors, Naiyer A Rizvi. less PLoS One, 2020 Sep 04; 15(9). PMID: 32881920 Free PMC article.
Molecular profiling of melanoma brain metastases compared to primary cutaneous melanoma and to extracranial metastases. Gino K In, Kelsey Poorman, +12 authors, Ari Vanderwalde. less Oncotarget, 2020 Sep 12; 11(33). PMID: 32913556 Free PMC article.
Efficacy and safety of immune checkpoint inhibitors in patients with advanced non-small cell lung cancer (NSCLC): a systematic literature review. Gernot Wagner, Hannah Karolina Stollenwerk, +3 authors, Josef Singer. less Oncoimmunology, 2020 Sep 15; 9(1). PMID: 32923134 Free PMC article. Systematic Review.
A meta-analysis comparing responses of Asian versus non-Asian cancer patients to PD-1 and PD-L1 inhibitor-based therapy. Ling Peng, Bao-Dong Qin, +5 authors, Li-Ping Xie. less Oncoimmunology, 2020 Sep 15; 9(1). PMID: 32923143 Free PMC article.
Intrahepatic Cholangiocarcinoma: Genomic Heterogeneity Between Eastern and Western Patients. Jingyu Cao, Jing Hu, +16 authors, Haitao Zhao. less JCO Precis Oncol, 2020 Sep 15; 4. PMID: 32923885 Free PMC article.
Next-Generation Sequencing of Advanced GI Tumors Reveals Individual Treatment Options. Michael Bitzer, Leonie Ostermann, +15 authors, Nisar P Malek. less JCO Precis Oncol, 2020 Sep 15; 4. PMID: 32923905 Free PMC article. Review.
Tumor immune profiles noninvasively estimated by FDG PET with deep learning correlate with immunotherapy response in lung adenocarcinoma. Changhee Park, Kwon Joong Na, +14 authors, Dae Seog Heo. less Theranostics, 2020 Sep 16; 10(23). PMID: 32929383 Free PMC article.
Biomarkers of immunotherapy in non-small cell lung cancer. Lingling Wang, Yue Hu, +2 authors, Shengchao Wang, Jiali Shen, Xiaochen Wang. less Oncol Lett, 2020 Sep 17; 20(5). PMID: 32934707 Free PMC article. Review.
Trial watch: TLR3 agonists in cancer therapy. Julie Le Naour, Lorenzo Galluzzi, +2 authors, Laurence Zitvogel, Guido Kroemer, Erika Vacchelli. less Oncoimmunology, 2020 Sep 17; 9(1). PMID: 32934877 Free PMC article. Review.
Trial watch: STING agonists in cancer therapy. Julie Le Naour, Laurence Zitvogel, +2 authors, Lorenzo Galluzzi, Erika Vacchelli, Guido Kroemer. less Oncoimmunology, 2020 Sep 17; 9(1). PMID: 32934881 Free PMC article. Review.
Trial watch: IDO inhibitors in cancer therapy. Julie Le Naour, Lorenzo Galluzzi, +2 authors, Laurence Zitvogel, Guido Kroemer, Erika Vacchelli. less Oncoimmunology, 2020 Sep 17; 9(1). PMID: 32934882 Free PMC article. Review.
Challenges of PD-L1 testing in non-small cell lung cancer and beyond. Minyu Wang, Sen Wang, Joseph A Trapani, Paul J Neeson. J Thorac Dis, 2020 Sep 19; 12(8). PMID: 32944371 Free PMC article.
The mechanism and risk factors for immune checkpoint inhibitor pneumonitis in non-small cell lung cancer patients. Xiaoyang Zhai, Jian Zhang, +4 authors, Hui Zhu. less Cancer Biol Med, 2020 Sep 19; 17(3). PMID: 32944393 Free PMC article. Review.
Tumor Mutational Burden, Toxicity, and Response of Immune Checkpoint Inhibitors Targeting PD(L)1, CTLA-4, and Combination: A Meta-regression Analysis. Arsen Osipov, Su Jin Lim, +6 authors, Mark Yarchoan. less Clin Cancer Res, 2020 Jun 27; 26(18). PMID: 32586938 Free PMC article.
Comprehensive serial biobanking in advanced NSCLC: feasibility, challenges and perspectives. Sabine Wessels, Thomas Muley, +17 authors, Marc A Schneider. less Transl Lung Cancer Res, 2020 Sep 22; 9(4). PMID: 32953480 Free PMC article.
Mass spectrometry-based serum proteomic signature as a potential biomarker for survival in patients with non-small cell lung cancer receiving immunotherapy. Young Kwang Chae, Won Bin Kim, +11 authors, Pedro Viveiros. less Transl Lung Cancer Res, 2020 Sep 22; 9(4). PMID: 32953481 Free PMC article.
A meta-analysis on immune checkpoint inhibitor efficacy for advanced non-small cell lung cancer between East Asians versus non-East Asians. Siyu Peng, Ariel Fangting Ying, Bee Choo Tai, Ross Andrew Soo. Transl Lung Cancer Res, 2020 Sep 22; 9(4). PMID: 32953491 Free PMC article.
Compare the efficacy and safety of programmed cell death-1 (PD-1) and programmed cell death ligand-1 (PD-L1) inhibitors for advanced non-small cell lung cancer: a Bayesian analysis. Jiaqi Liang, Ming Li, +7 authors, Lijie Tan. less Transl Lung Cancer Res, 2020 Sep 22; 9(4). PMID: 32953506 Free PMC article.
Effect of Gender on the Outcome of Patients Receiving Immune Checkpoint Inhibitors for Advanced Cancer: A Systematic Review and Meta-Analysis of Phase III Randomized Clinical Trials. Antonino Grassadonia, Isabella Sperduti, +11 authors, Nicola Tinari. less J Clin Med, 2018 Dec 14; 7(12). PMID: 30545122 Free PMC article.
The clinical promise of immunotherapy in triple-negative breast cancer. Praveen Vikas, Nicholas Borcherding, Weizhou Zhang. Cancer Manag Res, 2018 Dec 24; 10. PMID: 30573992 Free PMC article. Review.
Gene code CD274/PD-L1: from molecular basis toward cancer immunotherapy. Federico Pio Fabrizio, Domenico Trombetta, +3 authors, Lucia Anna Muscarella. less Ther Adv Med Oncol, 2018 Dec 24; 10. PMID: 30574211 Free PMC article. Review.
ASCO 2018 NSCLC highlights-combination therapy is key. Gabriele Gamerith, Florian Kocher, Jakob Rudzki, Andreas Pircher. Memo, 2019 Jan 01; 11(4). PMID: 30595752 Free PMC article. Review.
Non-invasive assessment of tumor PD-L1 status with circulating tumor cells. Bryan C Ulrich, Nicolas Guibert. Ann Transl Med, 2019 Jan 08; 6(Suppl 1). PMID: 30613623 Free PMC article.
Tumor mutation burden in lung cancer: a new predictive biomarker for immunotherapy or too soon to tell? Mariam Alexander, Jose Galeas, Haiying Cheng. J Thorac Dis, 2019 Jan 12; 10(Suppl 33). PMID: 30631537 Free PMC article.
PD-1 and PD-L1 inhibitor toxicities in non-small cell lung cancer. Bairavi Shankar, Jarushka Naidoo. J Thorac Dis, 2019 Jan 12; 10(Suppl 33). PMID: 30631548 Free PMC article.
Do toxicity patterns vary between programmed death-1 and programmed death ligand-1 inhibitors? Dwight H Owen, Gregory A Otterson. J Thorac Dis, 2019 Jan 12; 10(Suppl 33). PMID: 30631557 Free PMC article.
Significance of testing for TP53 gene mutations in lung adenocarcinoma using targeted gene sequencing. Yuki Matsumura, Yuki Owada-Ozaki, Hiroyuki Suzuki. J Thorac Dis, 2019 Jan 12; 10(Suppl 33). PMID: 30631578 Free PMC article.
Programmed Death-ligand 1 Expression With Clone 22C3 in Non-small Cell Lung Cancer: A Single Institution Experience. Maiko Takeda, Takahiko Kasai, +13 authors, Shinji Atagi. less Clin Med Insights Oncol, 2019 Jan 24; 13. PMID: 30670923 Free PMC article.
Mechanisms of Primary and Secondary Resistance to Immune Checkpoint Inhibitors in Cancer. Tiffany Seto, Danny Sam, Minggui Pan. Med Sci (Basel), 2019 Jan 27; 7(2). PMID: 30678257 Free PMC article. Review.
Biomarkers for the detection of apparent and subclinical cancer therapy-related cardiotoxicity. Lars Michel, Tienush Rassaf, Matthias Totzeck. J Thorac Dis, 2019 Feb 01; 10(Suppl 35). PMID: 30701097 Free PMC article. Highly Cited. Review.
The combination strategies will be ready the right first-line choice for squamous lung cancer patients? Cesare Gridelli, Francesca Casaluce. Transl Lung Cancer Res, 2019 Feb 02; 7(Suppl 4). PMID: 30705852 Free PMC article.
Tumor mutational burden as predictive factor of response to immunotherapy. Maria Gonzalez-Cao, Santiago Viteri, +3 authors, Rafael Rosell. less Transl Lung Cancer Res, 2019 Feb 02; 7(Suppl 4). PMID: 30705855 Free PMC article.
Severe toxicity from checkpoint protein inhibitors: What intensive care physicians need to know? Virginie Lemiale, Anne-Pascale Meert, +5 authors, Groupe de Recherche en Reanimation Respiratoire du patient d’Onco-Hématologie (Grrr-OH). less Ann Intensive Care, 2019 Feb 02; 9(1). PMID: 30707321 Free PMC article. Review.
The Role of Molecular Profiling to Predict the Response to Immune Checkpoint Inhibitors in Lung Cancer. Courèche Kaderbhaï, Zoé Tharin, François Ghiringhelli. Cancers (Basel), 2019 Feb 13; 11(2). PMID: 30744168 Free PMC article. Review.
Risk of immune-related adverse events associated with ipilimumab-plus-nivolumab and nivolumab therapy in cancer patients. Shi Zhou, Samrat Khanal, Haijun Zhang. Ther Clin Risk Manag, 2019 Feb 19; 15. PMID: 30774357 Free PMC article. Review.
Current views on tumor mutational burden in patients with non-small cell lung cancer treated by immune checkpoint inhibitors. Léa Berland, Simon Heeke, +11 authors, Marius Ilié. less J Thorac Dis, 2019 Feb 19; 11(Suppl 1). PMID: 30775030 Free PMC article. Review.
Update on emerging biomarkers in lung cancer. Eric H Bernicker, Timothy Craig Allen, Phillip T Cagle. J Thorac Dis, 2019 Feb 19; 11(Suppl 1). PMID: 30775031 Free PMC article. Review.
Circulating free tumor DNA in non-small cell lung cancer (NSCLC): clinical application and future perspectives. Guillaume Herbreteau, Audrey Vallée, +3 authors, Marc G Denis. less J Thorac Dis, 2019 Feb 19; 11(Suppl 1). PMID: 30775034 Free PMC article. Review.
Post-neoadjuvant treatment and the management of residual disease in breast cancer: state of the art and perspectives. Rafael Caparica, Matteo Lambertini, +3 authors, Martine Piccart. less Ther Adv Med Oncol, 2019 Mar 06; 11. PMID: 30833989 Free PMC article. Review.
Complete response associated with immune checkpoint inhibitors in advanced non-small-cell lung cancer: a meta-analysis of nine randomized controlled trials. Jie Li, Qi He, +3 authors, Xiu Yu, Khalid Khan, Xuanwen Weng, Minjie Guan. less Cancer Manag Res, 2019 Mar 14; 11. PMID: 30863172 Free PMC article.
Atypical patterns of response to immune checkpoint inhibitors: interpreting pseudoprogression and hyperprogression in decision making for patients' treatment. Concetta Elisa Onesti, Pierre Frères, Guy Jerusalem. J Thorac Dis, 2019 Mar 14; 11(1). PMID: 30863564 Free PMC article.
Are lung adenocarcinoma mutations shaping the immune microenvironment? Philippe Rochigneux, Edward B Garon. Transl Cancer Res, 2019 Mar 25; 7(Suppl 7). PMID: 30906701 Free PMC article.
Advances in Targeted Therapy and Immunotherapy for Non-small Cell Lung Cancer Based on Accurate Molecular Typing. Jingsi Dong, Bingjie Li, +2 authors, Dan Lin, Qinghua Zhou, Depei Huang. less Front Pharmacol, 2019 Apr 02; 10. PMID: 30930778 Free PMC article. Highly Cited. Review.
A Changing of the Guard: Immune Checkpoint Inhibitors With and Without Chemotherapy as First Line Treatment for Metastatic Non-small Cell Lung Cancer. Jose M Pacheco, D Ross Camidge, Robert C Doebele, Erin Schenk. Front Oncol, 2019 Apr 16; 9. PMID: 30984621 Free PMC article. Highly Cited. Review.
The ABCs of preventing hyperprogressive disease after immunotherapy: awareness, biomarkers, and combination. Kenichi Suda. J Thorac Dis, 2019 Apr 19; 11(Suppl 3). PMID: 30997217 Free PMC article.
KEYNOTE-024: goodbye to chemotherapy? Rossana Berardi. J Thorac Dis, 2019 Apr 19; 11(Suppl 3). PMID: 30997239 Free PMC article.
The metastatic dissemination of a squamous cell carcinoma arising from an epidermal cyst and subsequent failure to respond to programmed death 1 inhibition. Melissa A Lumish, Mark A Anderson, +4 authors, Meghan J Mooradian. less JAAD Case Rep, 2019 Apr 23; 5(4). PMID: 31008173 Free PMC article.
Immunophenotype of T Cells Expressing Programmed Death-1 and Cytotoxic T Cell Antigen-4 in Early Lung Cancer: Local vs. Systemic Immune Response. Iwona Kwiecien, Tomasz Skirecki, +2 authors, Joanna Domagala-Kulawik. less Cancers (Basel), 2019 Apr 24; 11(4). PMID: 31010080 Free PMC article.
The Discovery of Biomarkers in Cancer Immunotherapy. Anil P George, Timothy M Kuzel, Yi Zhang, Bin Zhang. Comput Struct Biotechnol J, 2019 Apr 24; 17. PMID: 31011407 Free PMC article. Review.
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Systemic therapy of elderly patients with advanced non-small cell lung cancer-individualized treatment is key. Robert Pirker. Ann Transl Med, 2019 Apr 30; 7(Suppl 1). PMID: 31032327 Free PMC article.
Beyond PD-1/PD-L1 Inhibition: What the Future Holds for Breast Cancer Immunotherapy. Sebastian Chrétien, Ioannis Zerdes, +2 authors, Jonas Bergh, Alexios Matikas, Theodoros Foukakis. less Cancers (Basel), 2019 May 08; 11(5). PMID: 31060337 Free PMC article. Review.
Incidence risk of PD-1/PD-L1 related diarrhea in non-small cell lung cancer (NSCLC) patients: a systematic review and meta-analysis. Caiqing Zhang, Shuisheng Zhang, +5 authors, Yuan Tian. less Cancer Manag Res, 2019 May 24; 11. PMID: 31118808 Free PMC article.
And They Said It Couldn't Be Done: Predicting Known Driver Mutations From H&E Slides. Michael C Montalto, Robin Edwards. J Pathol Inform, 2019 Jun 01; 10. PMID: 31149368 Free PMC article.
Liquid biopsy for lung cancer immunotherapy. Liang-Liang Cai, Jie Wang. Oncol Lett, 2019 Jun 13; 17(6). PMID: 31186680 Free PMC article. Review.
Efficacy and safety of programmed death 1 inhibitors in patients with advanced non-small cell lung cancer: a meta-analysis. Yi Liu, Sijing Zhou, +5 authors, Ran Wang. less Cancer Manag Res, 2019 Jun 14; 11. PMID: 31191023 Free PMC article. Review.
Immune Checkpoint Inhibition in Classical Hodgkin Lymphoma: From Early Achievements towards New Perspectives. Diego De Goycoechea, Gregoire Stalder, Filipe Martins, Michel A Duchosal. J Oncol, 2019 Jun 18; 2019. PMID: 31205470 Free PMC article. Review.
Resistance to Systemic Agents in Renal Cell Carcinoma Predict and Overcome Genomic Strategies Adopted by Tumor. Veronica Mollica, Vincenzo Di Nunno, +8 authors, Francesco Massari. less Cancers (Basel), 2019 Jun 19; 11(6). PMID: 31207938 Free PMC article. Review.
Nivolumab plus ipilimumab combination therapy for the first-line treatment NSCLC: evidence to date. Jordi Remon, Laura Esteller, Álvaro Taus. Cancer Manag Res, 2019 Jun 20; 11. PMID: 31213908 Free PMC article. Review.
Highlights of thoracic oncology from the 2018 ERS International Congress. Polyxeni Ntontsi, Clementine Bostantzoglou, Torsten Gerriet Blum. ERJ Open Res, 2019 Jun 21; 5(2). PMID: 31218220 Free PMC article. Review.
Prospective Comprehensive Genomic Profiling of Primary and Metastatic Prostate Tumors. Jon H Chung, Ninad Dewal, +15 authors, Neeraj Agarwal. less JCO Precis Oncol, 2019 Jun 21; 3. PMID: 31218271 Free PMC article.
Combination pembrolizumab plus chemotherapy: a new standard of care for patients with advanced non-small-cell lung cancer. Frank Weinberg, Shirish Gadgeel. Lung Cancer (Auckl), 2019 Jun 27; 10. PMID: 31239797 Free PMC article.
Negativation of PD-L1 Postoperatively in Initially Inoperable Stage III Non-Small Cell Lung Cancer Treated with Pembrolizumab: Two Case Reports. Fadi Nasr, Ahmad Al Ghoche, +4 authors, Moussa Riachi. less Case Rep Oncol, 2019 Jun 28; 12(2). PMID: 31244645 Free PMC article.
Association Between Tumor Mutation Burden (TMB) and Outcomes of Cancer Patients Treated With PD-1/PD-L1 Inhibitions: A Meta-Analysis. Jiaxin Zhu, Tiantian Zhang, +5 authors, Jie Jiang. less Front Pharmacol, 2019 Jul 02; 10. PMID: 31258479 Free PMC article. Systematic Review.
Possible Biomarkers for Cancer Immunotherapy. Takehiro Otoshi, Tatsuya Nagano, Motoko Tachihara, Yoshihiro Nishimura. Cancers (Basel), 2019 Jul 07; 11(7). PMID: 31277279 Free PMC article. Review.
Immune-Related Adverse Events: A Case-Based Approach. Caoilfhionn Connolly, Kalindi Bambhania, Jarushka Naidoo. Front Oncol, 2019 Jul 12; 9. PMID: 31293970 Free PMC article. Review.
Baseline Absolute Lymphocyte Count and ECOG Performance Score Are Associated with Survival in Advanced Non-Small Cell Lung Cancer Undergoing PD-1/PD-L1 Blockade. Florian Huemer, David Lang, +7 authors, Richard Greil. less J Clin Med, 2019 Jul 13; 8(7). PMID: 31295966 Free PMC article.
A pooled meta-analysis of PD-1/L1 inhibitors incorporation therapy for advanced non-small cell lung cancer. Ning Wan, Bo Ji, +4 authors, Wenjie Huang. less Onco Targets Ther, 2019 Jul 16; 12. PMID: 31303759 Free PMC article. Review.
PD-1/PD-L1 Targeting in Breast Cancer: The First Clinical Evidences Are Emerging. A Literature Review. Gabrielle Planes-Laine, Philippe Rochigneux, +4 authors, Anthony Gonçalves. less Cancers (Basel), 2019 Jul 25; 11(7). PMID: 31336685 Free PMC article. Highly Cited. Review.
Strategies to Augment Natural Killer (NK) Cell Activity against Solid Tumors. Ziqing Chen, Ying Yang, Lisa L Liu, Andreas Lundqvist. Cancers (Basel), 2019 Jul 26; 11(7). PMID: 31340613 Free PMC article. Review.
Immune checkpoint inhibitors for small cell lung cancer: opportunities and challenges. Orgilmaa Regzedmaa, Hongbing Zhang, Hongyu Liu, Jun Chen. Onco Targets Ther, 2019 Jul 30; 12. PMID: 31354294 Free PMC article.
Significant benefit of nivolumab combining radiotherapy in metastatic gallbladder cancer patient with strong PD-L1 expression: a case report. Weiwei Kong, Jia Wei, +6 authors, Baorui Liu. less Onco Targets Ther, 2019 Jul 31; 12. PMID: 31360065 Free PMC article.
Molecular testing strategies in non-small cell lung cancer: optimizing the diagnostic journey. Jeffrey P Gregg, Tianhong Li, Ken Y Yoneda. Transl Lung Cancer Res, 2019 Aug 02; 8(3). PMID: 31367542 Free PMC article. Review.
Blood-based tumor mutation burden: continued progress toward personalizing immunotherapy in non-small cell lung cancer. Vincent K Lam, Jianjun Zhang. J Thorac Dis, 2019 Aug 03; 11(6). PMID: 31372254 Free PMC article.
Tumor mutation burden: from comprehensive mutational screening to the clinic. Francesca Galuppini, Carlo Alberto Dal Pozzo, +3 authors, Raffaele Baffa. less Cancer Cell Int, 2019 Aug 14; 19. PMID: 31406485 Free PMC article. Review.
The Promise of Digital Biopsy for the Prediction of Tumor Molecular Features and Clinical Outcomes Associated With Immunotherapy. Giuseppe Luigi Banna, Timothée Olivier, +4 authors, Alfredo Addeo. less Front Med (Lausanne), 2019 Aug 17; 6. PMID: 31417906 Free PMC article.
First-line immune checkpoint inhibitors for advanced non-small cell lung cancer with wild-type epidermal growth factor receptor (EGFR) or anaplastic lymphoma kinase (ALK): a systematic review and network meta-analysis. Tingting Liu, Silu Ding, +3 authors, Jun Dang, Hui Wang, Jun Chen, Guang Li. less J Thorac Dis, 2019 Aug 30; 11(7). PMID: 31463119 Free PMC article.
Excellent Response to Nivolumab and Ipilimumab in Metastatic Gastroesophageal Junction Squamous Carcinoma. Narayanan Sadagopan, Craig Devoe. Case Rep Oncol Med, 2019 Aug 31; 2019. PMID: 31467751 Free PMC article.
The evolving immuno-oncology landscape in advanced lung cancer: first-line treatment of non-small cell lung cancer. Jia Li Low, Robert J Walsh, +2 authors, Yvonne Ang, Gloria Chan, Ross A Soo. less Ther Adv Med Oncol, 2019 Sep 10; 11. PMID: 31497071 Free PMC article. Review.
Liquid biopsy for lung cancers: an update on recent developments. Alberto E Revelo, Alvaro Martin, +4 authors, Gregory Otterson. less Ann Transl Med, 2019 Sep 14; 7(15). PMID: 31516895 Free PMC article. Review.
The role of endobronchial ultrasound transbronchial needle aspiration for programmed death ligand 1 testing and next generation sequencing in advanced non-small cell lung cancer. Udit Chaddha, D Kyle Hogarth, Septimiu Murgu. Ann Transl Med, 2019 Sep 14; 7(15). PMID: 31516897 Free PMC article. Review.
Androgen Receptor Signaling in the Development of Castration-Resistant Prostate Cancer. Qin Feng, Bin He. Front Oncol, 2019 Sep 26; 9. PMID: 31552182 Free PMC article. Review.
The shifting paradigm of biomarker-driven care in advanced non-small cell lung cancer (NSCLC). Greg Durm, Nasser Hanna. Transl Lung Cancer Res, 2019 Sep 27; 8(4). PMID: 31555527 Free PMC article.
Characterization of tumour mutation burden in patients with non-small cell lung cancer and interstitial lung disease. Haruki Kobayashi, Masakuni Serizawa, +12 authors, Toshiaki Takahashi. less Respirology, 2019 Nov 07; 25(8). PMID: 31694070 Free PMC article.
Recommendations to improve the clinical adoption of NGS-based cancer diagnostics in Singapore. David Shao-Peng Tan, Daniel Shao-Weng Tan, +4 authors, William Ying Khee Hwang. less Asia Pac J Clin Oncol, 2020 Apr 18; 16(4). PMID: 32301274 Free PMC article. Review.
Neoadjuvant nivolumab plus ipilimumab in resectable non-small cell lung cancer. Joshua E Reuss, Valsamo Anagnostou, +29 authors, Patrick M Forde. less J Immunother Cancer, 2020 Sep 16; 8(2). PMID: 32929052 Free PMC article.
New biomarkers for checkpoint inhibitor therapy. Nikki Burdett, Jayesh Desai. ESMO Open, 2020 Sep 17; 5(Suppl 1). PMID: 32933940 Free PMC article. Review.
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Excision Repair Cross Complementation Group 1 Single Nucleotide Polymorphisms and Nivolumab in Advanced Non-Small Cell Lung Cancer. Marco Maria Aiello, Cinzia Solinas, +8 authors, Hector Josè Soto Parra. less Front Oncol, 2020 Sep 29; 10. PMID: 32983959 Free PMC article.
Prevalence of Phosphatidylinositol-3-Kinase (PI3K) Pathway Alterations and Co-alteration of Other Molecular Markers in Breast Cancer. Katia Khoury, Antoinette R Tan, +10 authors, Filipa Lynce. less Front Oncol, 2020 Sep 29; 10. PMID: 32983983 Free PMC article.
Multimodal genomic features predict outcome of immune checkpoint blockade in non-small-cell lung cancer. Valsamo Anagnostou, Noushin Niknafs, +32 authors, Victor E Velculescu. less Nat Cancer, 2020 Sep 29; 1(1). PMID: 32984843 Free PMC article.
Immunotherapy in older patients with non-small cell lung cancer: Young International Society of Geriatric Oncology position paper. Fabio Gomes, Melisa Wong, +4 authors, Andrea Luciani. less Br J Cancer, 2020 Jul 23; 123(6). PMID: 32694695 Free PMC article. Review.
Hyperprogression: A novel response pattern under immunotherapy. Xue-Jiao Han, Aqu Alu, +2 authors, Yi-Nan Xiao, Yu-Quan Wei, Xia-Wei Wei. less Clin Transl Med, 2020 Oct 01; 10(5). PMID: 32997401 Free PMC article. Review.
Relationship between MLH1, PMS2, MSH2 and MSH6 gene-specific alterations and tumor mutational burden in 1057 microsatellite instability-high solid tumors. Mohamed E Salem, J Nicholas Bodor, +10 authors, Michael J Hall. less Int J Cancer, 2020 May 26; 147(10). PMID: 32449172 Free PMC article.
The New Immunotherapy Combinations in the Treatment of Advanced Non-Small Cell Lung Cancer: Reality and Perspectives. Danilo Rocco, Luigi D Gravara, Cesare Gridelli. Curr Clin Pharmacol, 2019 Aug 11; 15(1). PMID: 31400270 Free PMC article. Review.
Cost-Effectiveness Analysis of Nivolumab Plus Ipilimumab vs. Chemotherapy as First-Line Therapy in Advanced Non-Small Cell Lung Cancer. Huabin Hu, Longjiang She, +7 authors, Jin Huang. less Front Oncol, 2020 Oct 06; 10. PMID: 33014826 Free PMC article.
Immune-Related Adverse Events and Corticosteroid Use for Cancer-Related Symptoms Are Associated With Efficacy in Patients With Non-small Cell Lung Cancer Receiving Anti-PD-(L)1 Blockade Agents. Mariona Riudavets, Joaquin Mosquera, +9 authors, Margarita Majem. less Front Oncol, 2020 Oct 06; 10. PMID: 33014837 Free PMC article.
Gut bacteria affect the tumoral immune milieu: distorting the efficacy of immunotherapy or not？. Pu Xiaoyu, Ge Chao, Dong Lihua, Chang Pengyu. Gut Microbes, 2020 Mar 29; 11(4). PMID: 32216675 Free PMC article. Review.
A phase II study of daily carboplatin plus irradiation followed by durvalumab for stage III non-small cell lung cancer patients with PS 2 up to 74 years old and patients with PS 0 or 1 from 75 years: NEJ039A (trial in progress). Kyoichi Kaira, Atsuto Mouri, +3 authors, Kunihiko Kobayashi. less BMC Cancer, 2020 Oct 08; 20(1). PMID: 33023530 Free PMC article.
The mutational landscape of the SCAN-B real-world primary breast cancer transcriptome. Christian Brueffer, Sergii Gladchuk, +12 authors, Lao H Saal. less EMBO Mol Med, 2020 Sep 15; 12(10). PMID: 32926574 Free PMC article.
Cancer patients in SARS-CoV-2 infection: a single-center experience from Wuhan. Jiafeng Wang, Jun Zhang, +6 authors, Minghua Ge. less J Cancer, 2020 Oct 10; 11(21). PMID: 33033507 Free PMC article.
Anti-PD-1 antibody SHR-1210 plus apatinib for metastatic colorectal cancer: a prospective, single-arm, open-label, phase II trial. Chao Ren, Zong-Jiong Mai, +7 authors, Rui-Hua Xu. less Am J Cancer Res, 2020 Oct 13; 10(9). PMID: 33042628 Free PMC article.
Pneumonitis Induced by Immune Checkpoint Inhibitors: From Clinical Data to Translational Investigation. Shicong Zhu, Yang Fu, +2 authors, Bo Zhu, Bicheng Zhang, Jun Wang. less Front Oncol, 2020 Oct 13; 10. PMID: 33042827 Free PMC article. Review.
Tumor Microenvironment-Associated Immune-Related Genes for the Prognosis of Malignant Pleural Mesothelioma. Xiaoling Xu, Lei Cheng, Yun Fan, Weimin Mao. Front Oncol, 2020 Oct 13; 10. PMID: 33042835 Free PMC article.
Safety, Antitumor Activity, and Pharmacokinetics of Toripalimab, a Programmed Cell Death 1 Inhibitor, in Patients With Advanced Non-Small Cell Lung Cancer: A Phase 1 Trial. Zhijie Wang, Jianming Ying, +13 authors, Jie Wang. less JAMA Netw Open, 2020 Oct 06; 3(10). PMID: 33017026 Free PMC article.
Immune checkpoint inhibitor-related dermatologic adverse events. Amaris N Geisler, Gregory S Phillips, +5 authors, Mario E Lacouture. less J Am Acad Dermatol, 2020 May 27; 83(5). PMID: 32454097 Free PMC article. Review.
Noninvasive Early Identification of Therapeutic Benefit from Immune Checkpoint Inhibition. Barzin Y Nabet, Mohammad S Esfahani, +29 authors, Maximilian Diehn. less Cell, 2020 Oct 03; 183(2). PMID: 33007267 Free PMC article.
Genetic Features of Lung Adenocarcinoma with Ground- Glass Opacity: What Causes the Invasiveness of Lung Adenocarcinoma? Dohun Kim, Jong-Young Lee, Jin Young Yoo, Jun Yeun Cho. Korean J Thorac Cardiovasc Surg, 2020 Oct 07; 53(5). PMID: 33020345 Free PMC article.
Impact of Age on the Efficacy of Immune Checkpoint Inhibitor-Based Combination Therapy for Non-small-Cell Lung Cancer: A Systematic Review and Meta-Analysis. Xin Yan, Xuan Tian, Zhiqiang Wu, Weidong Han. Front Oncol, 2020 Oct 20; 10. PMID: 33072551 Free PMC article. Systematic Review.
A Potential Biomarker of Combination of Tumor Mutation Burden and Copy Number Alteration for Efficacy of Immunotherapy in KRAS-Mutant Advanced Lung Adenocarcinoma. Luochengling Xiang, Xiao Fu, +4 authors, Tao Tian. less Front Oncol, 2020 Oct 20; 10. PMID: 33072585 Free PMC article.
DNA Repair and Signaling in Immune-Related Cancer Therapy. Sangeeta Kakoti, Hiro Sato, +2 authors, Siddhartha Laskar, Takaaki Yasuhara, Atsushi Shibata. less Front Mol Biosci, 2020 Oct 27; 7. PMID: 33102516 Free PMC article.
Biomarkers or factors for predicting the efficacy and adverse effects of immune checkpoint inhibitors in lung cancer: achievements and prospective. Wen-Jia Shi, Wei Zhao. Chin Med J (Engl), 2020 Sep 23; 133(20). PMID: 32960841 Free PMC article. Review.
Lung cancer treatment in the era of immunotherapy. Yang Xu, Liang-An Chen. Chin Med J (Engl), 2020 Sep 25; 133(20). PMID: 32969863 Free PMC article.
Mechanisms of resistance to immune checkpoint inhibitors and strategies to reverse drug resistance in lung cancer. Fang-Fei Qian, Bao-Hui Han. Chin Med J (Engl), 2020 Sep 25; 133(20). PMID: 32969861 Free PMC article. Review.
The relationship between pneumonitis and programmed cell death-1/programmed cell death ligand 1 inhibitors among cancer patients: A systematic review and meta-analysis. Dongmei Xu, Hongmei Liu, +7 authors, Yuan Tian. less Medicine (Baltimore), 2020 Oct 09; 99(41). PMID: 33031304 Free PMC article. Systematic Review.
Exploration of Feasible Immune Biomarkers for Immune Checkpoint Inhibitors in Head and Neck Squamous Cell Carcinoma Treatment in Real World Clinical Practice. Hui-Ching Wang, Tsung-Jang Yeh, +2 authors, Leong-Perng Chan, Chin-Mu Hsu, Shih-Feng Cho. less Int J Mol Sci, 2020 Oct 21; 21(20). PMID: 33076306 Free PMC article. Review.
First-Line Immune-Checkpoint Inhibitors in Non-Small Cell Lung Cancer: Current Landscape and Future Progress. Zhangfeng Huang, Wenhao Su, +6 authors, Wenjie Jiao. less Front Pharmacol, 2020 Oct 30; 11. PMID: 33117170 Free PMC article. Review.
Microbiota and Lung Cancer. Opportunities and Challenges for Improving Immunotherapy Efficacy. Maitane Ocáriz-Díez, Mara Cruellas, +10 authors, Eva M Gálvez. less Front Oncol, 2020 Oct 30; 10. PMID: 33117698 Free PMC article. Review.
[Chinese Expert Consensus on Next Generation Sequencing Diagnosis  for Non-small Cell Lung Cancer (2020 Edition)]. Chinese Society of Clinical Oncology, Expert Committee on Non-small Cell Lung Cancer. Zhongguo Fei Ai Za Zhi, 2020 Sep 22; 23(9). PMID: 32957170 Free PMC article.
From Tumor Mutational Burden to Blood T Cell Receptor: Looking for the Best Predictive Biomarker in Lung Cancer Treated with Immunotherapy. Andrea Sesma, Julián Pardo, +12 authors, Rodrigo Lastra. less Cancers (Basel), 2020 Oct 18; 12(10). PMID: 33066479 Free PMC article. Review.
Iodine-125 radioactive particles antagonize hyperprogressive disease following immunotherapy: A case report. Ning Yang, Pin-Liang Zhang, Zeng-Jun Liu. Medicine (Baltimore), 2020 Nov 01; 99(44). PMID: 33126358 Free PMC article.
Biomarkers in immunotherapy: literature review and future directions. Rebecca Pharaon, Maria A Koczywas, +2 authors, Sabrina Salgia, Atish Mohanty, Erminia Massarelli. less J Thorac Dis, 2020 Nov 05; 12(9). PMID: 33145089 Free PMC article. Review.
Tumor-Derived IL33 Promotes Tissue-Resident CD8+ T Cells and Is Required for Checkpoint Blockade Tumor Immunotherapy. Lujun Chen, Runzi Sun, +9 authors, Binfeng Lu. less Cancer Immunol Res, 2020 Sep 13; 8(11). PMID: 32917659 Free PMC article.
Prevalence of High Tumor Mutational Burden and Association With Survival in Patients With Less Common Solid Tumors. Changxia Shao, Gerald Li, +10 authors, Wei Zhou. less JAMA Netw Open, 2020 Oct 30; 3(10). PMID: 33119110 Free PMC article.
Converging focal radiation and immunotherapy in a preclinical model of triple negative breast cancer: contribution of VISTA blockade. Karsten A Pilones, Michal Hensler, +5 authors, Silvia C Formenti. less Oncoimmunology, 2020 Nov 06; 9(1). PMID: 33150045 Free PMC article.
BTN3A1 governs antitumor responses by coordinating αβ and γδ T cells. Kyle K Payne, Jessica A Mine, +24 authors, Jose R Conejo-Garcia. less Science, 2020 Aug 21; 369(6506). PMID: 32820120 Free PMC article.
De novo necroptosis creates an inflammatory environment mediating tumor susceptibility to immune checkpoint inhibitors. Samuel T Workenhe, Andrew Nguyen, +12 authors, Karen L Mossman. less Commun Biol, 2020 Nov 06; 3(1). PMID: 33149194 Free PMC article.
Phase I/II Trial of Immunotherapy With Durvalumab and Tremelimumab With Continuous or Intermittent MEK Inhibitor Selumetinib in NSCLC: Early Trial Report. Pierre-Olivier Gaudreau, J Jack Lee, John V Heymach, Don L Gibbons. Clin Lung Cancer, 2020 Apr 18; 21(4). PMID: 32299768 Free PMC article.
Update Breast Cancer 2020 Part 4 - Advanced Breast Cancer. Hans Tesch, Volkmar Müller, +16 authors, Wolfgang Janni. less Geburtshilfe Frauenheilkd, 2020 Nov 12; 80(11). PMID: 33173239 Free PMC article.
The risk of diarrhea and colitis in patients with lung cancer treated with immune checkpoint inhibitors: a systematic review and meta-analysis. K Bishay, P Tandon, +2 authors, S Bourassa-Blanchette, S A Laurie, J D McCurdy. less Curr Oncol, 2020 Nov 12; 27(5). PMID: 33173388 Free PMC article. Systematic Review.
Emerging Blood-Based Biomarkers for Predicting Response to Checkpoint Immunotherapy in Non-Small-Cell Lung Cancer. Shumin Li, Chengyan Zhang, Guanchao Pang, Pingli Wang. Front Immunol, 2020 Nov 13; 11. PMID: 33178229 Free PMC article. Systematic Review.
Delicate Role of PD-L1/PD-1 Axis in Blood Vessel Inflammatory Diseases: Current Insight and Future Significance. Priya Veluswamy, Max Wacker, Maximilian Scherner, Jens Wippermann. Int J Mol Sci, 2020 Nov 05; 21(21). PMID: 33142805 Free PMC article. Review.
Pretreatment Blood Parameters Predict Efficacy from Immunotherapy Agents in Early Phase Clinical Trials. Carmen Criscitiello, Antonio Marra, +4 authors, Giuseppe Curigliano. less Oncologist, 2020 Aug 14; 25(11). PMID: 32785940 Free PMC article.
Early palliative care of non-small cell lung cancer in the context of immunotherapy. Małgorzata Pieniążek, Piotr Pawlak, Barbara Radecka. Oncol Lett, 2020 Nov 17; 20(6). PMID: 33193856 Free PMC article. Review.
The Resistance Mechanisms of Lung Cancer Immunotherapy. Fen Wang, Shubin Wang, Qing Zhou. Front Oncol, 2020 Nov 17; 10. PMID: 33194652 Free PMC article. Review.
Integration of the Tumor Mutational Burden and Tumor Heterogeneity Identify an Immunological Subtype of Melanoma With Favorable Survival. Yanmei Gao, Chunhe Yang, +3 authors, Ning He, Guodong Zhao, Jianfei Wang, Yadong Yang. less Front Oncol, 2020 Nov 17; 10. PMID: 33194669 Free PMC article.
Genomic alterations of whole exome sequencing in esophageal squamous cell carcinoma before and after radiotherapy. Guixiang Weng, Wei Zhao, +6 authors, Shuanghu Yuan. less J Thorac Dis, 2020 Nov 20; 12(10). PMID: 33209427 Free PMC article.
The effect of PD-L1 categories-directed pembrolizumab plus chemotherapy for newly diagnosed metastatic non-small-cell lung cancer: a cost-effectiveness analysis. Bin Wu, Shun Lu. Transl Lung Cancer Res, 2020 Nov 20; 9(5). PMID: 33209600 Free PMC article.
FLAURA strikes again: efficacy of osimertinib is independent of PD-L1 expression. Pamela Abdayem, David Planchard. Transl Lung Cancer Res, 2020 Nov 20; 9(5). PMID: 33209637 Free PMC article.
Dual Checkpoint Blockade in a Neuroendocrine Carcinoma With Dual PD-L1/PD-L2 Amplification and High Tumor Mutational Burden. Jun Gong, Sandip Patel, +9 authors, Andrew E Hendifar. less JCO Precis Oncol, 2020 Nov 21; 4. PMID: 33215052 Free PMC article.
Tumor-associated macrophage, angiogenesis and lymphangiogenesis markers predict prognosis of non-small cell lung cancer patients. Ilseon Hwang, Jeong Won Kim, +7 authors, Stephen M Hewitt. less J Transl Med, 2020 Nov 25; 18(1). PMID: 33228719 Free PMC article.
Plasma plastin-3: A tumor marker in patients with non-small-cell lung cancer treated with nivolumab. Kengo Kuriyama, Takehiko Yokobori, +7 authors, Hiroshi Saeki. less Oncol Lett, 2020 Nov 27; 21(1). PMID: 33240417 Free PMC article.
Implementing ctDNA Analysis in the Clinic: Challenges and Opportunities in Non-Small Cell Lung Cancer. Elisa Gobbini, Aurélie Swalduz, +5 authors, Pierre Saintigny. less Cancers (Basel), 2020 Oct 30; 12(11). PMID: 33114393 Free PMC article. Review.
Quantifying PD-L1 Expression to Monitor Immune Checkpoint Therapy: Opportunities and Challenges. Sridhar Nimmagadda. Cancers (Basel), 2020 Nov 04; 12(11). PMID: 33137949 Free PMC article. Review.
Immune Checkpoint Blockade in Gynecologic Cancers: State of Affairs. Maureen L Drakes, Cheryl M Czerlanis, Patrick J Stiff. Cancers (Basel), 2020 Nov 14; 12(11). PMID: 33182298 Free PMC article. Review.
Recent Advances in the Clinical Development of Immune Checkpoint Blockade Therapy for Mismatch Repair Proficient (pMMR)/non-MSI-H Metastatic Colorectal Cancer. James J Lee, Edward Chu. Clin Colorectal Cancer, 2018 Aug 04; 17(4). PMID: 30072278 Free PMC article. Review.
[Personalized cancer medicine : Biomarkers for molecular therapy stratification in pancreatic carcinoma]. S Ormanns. Pathologe, 2018 Oct 27; 39(Suppl 2). PMID: 30361776 Review.
The lung microenvironment: an important regulator of tumour growth and metastasis. Nasser K Altorki, Geoffrey J Markowitz, +5 authors, Vivek Mittal. less Nat Rev Cancer, 2018 Dec 12; 19(1). PMID: 30532012 Free PMC article. Highly Cited. Review.
LCE: an open web portal to explore gene expression and clinical associations in lung cancer. Ling Cai, ShinYi Lin, +15 authors, Yang Xie. less Oncogene, 2018 Dec 12; 38(14). PMID: 30532070 Free PMC article.
Combining Radiotherapy and Immunotherapy in Lung Cancer: Can We Expect Limitations Due to Altered Normal Tissue Toxicity? Florian Wirsdörfer, Simone de Leve, Verena Jendrossek. Int J Mol Sci, 2018 Dec 24; 20(1). PMID: 30577587 Free PMC article. Review.
Current status of immune checkpoint inhibitors in treatment of non-small cell lung cancer. Sung Won Lim, Myung-Ju Ahn. Korean J Intern Med, 2019 Jan 08; 34(1). PMID: 30612418 Free PMC article. Review.
Oligonucleotide Therapeutics as a New Class of Drugs for Malignant Brain Tumors: Targeting mRNAs, Regulatory RNAs, Mutations, Combinations, and Beyond. Anna M Krichevsky, Erik J Uhlmann. Neurotherapeutics, 2019 Jan 16; 16(2). PMID: 30644073 Free PMC article. Review.
Screening responsive or resistant biomarkers of immune checkpoint inhibitors based on online databases. Zhen Xiang, Yingyan Yu. Front Med, 2019 Jan 20; 13(1). PMID: 30659409 Review.
Monitoring checkpoint inhibitors: predictive biomarkers in immunotherapy. Min Zhang, Jingwen Yang, +3 authors, Wenjing Hua, Zhong Li, Zenghui Xu, Qijun Qian. less Front Med, 2019 Jan 27; 13(1). PMID: 30680606 Review.
Programmed death ligand 1 expression in early stage, resectable non-small cell lung cancer. Manolo D'Arcangelo, Armida D'Incecco, +14 authors, Federico Cappuzzo. less Oncotarget, 2019 Feb 08; 10(5). PMID: 30728907 Free PMC article.
Recent success and limitations of immune checkpoint inhibitors for cancer: a lesson from melanoma. Margaret Ottaviano, Sabino De Placido, Paolo Antonio Ascierto. Virchows Arch, 2019 Feb 13; 474(4). PMID: 30747264 Review.
The evolving landscape of biomarkers for checkpoint inhibitor immunotherapy. Jonathan J Havel, Diego Chowell, Timothy A Chan. Nat Rev Cancer, 2019 Feb 14; 19(3). PMID: 30755690 Free PMC article. Highly Cited. Review.
Efficacy of nintedanib and docetaxel in patients with advanced lung adenocarcinoma treated with first-line chemotherapy and second-line immunotherapy in the nintedanib NPU program. J Corral, M Majem, +7 authors, M P López Criado. less Clin Transl Oncol, 2019 Feb 17; 21(9). PMID: 30771085
Targeting Immune Checkpoints in Lung Cancer: Current Landscape and Future Prospects. Long Long, Chen Zhao, +3 authors, Honglei Chen. less Clin Drug Investig, 2019 Feb 20; 39(4). PMID: 30778885 Review.
Implementing TMB measurement in clinical practice: considerations on assay requirements. Reinhard Büttner, John W Longshore, +4 authors, Frédérique Penault-Llorca. less ESMO Open, 2019 Feb 23; 4(1). PMID: 30792906 Free PMC article. Highly Cited.
Impact of early inflammatory cytokine elevation after commencement of PD-1 inhibitors to predict efficacy in patients with non-small cell lung cancer. Yuichi Ozawa, Yusuke Amano, +8 authors, Takafumi Suda. less Med Oncol, 2019 Mar 03; 36(4). PMID: 30825015
Recent treatment strategy for advanced squamous cell carcinoma of the lung in Japan. Satoru Senoo, Kiichiro Ninomiya, Katsuyuki Hotta, Katsuyuki Kiura. Int J Clin Oncol, 2019 Mar 09; 24(5). PMID: 30847617 Review.
KRAS-mutant non-small cell lung cancer: Converging small molecules and immune checkpoint inhibition. Helen Adderley, Fiona H Blackhall, Colin R Lindsay. EBioMedicine, 2019 Mar 11; 41. PMID: 30852159 Free PMC article. Highly Cited. Review.
Prognostic impact of mitochondrial DNA D-loop variations in pediatric acute myeloid leukemia. Anudishi Tyagi, Raja Pramanik, +2 authors, Sameer Bakhshi. less Oncotarget, 2019 Mar 14; 10(13). PMID: 30863493 Free PMC article.
＜Editors' Choice＞ Meddling with meddlers: curbing regulatory T cells and augmenting antitumor immunity. Vitaly Kochin, Hiroyoshi Nishikawa. Nagoya J Med Sci, 2019 Apr 10; 81(1). PMID: 30962651 Free PMC article. Review.
Clinical impact of PD-L1 and PD-1 expression in squamous cell cancer of the vulva. Fabinshy Thangarajah, Bernd Morgenstern, +9 authors, Anne Maria Schultheis. less J Cancer Res Clin Oncol, 2019 Apr 12; 145(6). PMID: 30972492
Telomerase-Targeted Cancer Immunotherapy. Eishiro Mizukoshi, Shuichi Kaneko. Int J Mol Sci, 2019 Apr 25; 20(8). PMID: 31013796 Free PMC article. Review.
PD-L1 expression and tumor mutational burden status for prediction of response to chemotherapy and targeted therapy in non-small cell lung cancer. Yanhui Chen, Quanxing Liu, +8 authors, Henghui Zhang. less J Exp Clin Cancer Res, 2019 May 16; 38(1). PMID: 31088500 Free PMC article.
Risk of dermatologic and mucosal adverse events associated with PD-1/PD-L1 inhibitors in cancer patients: A meta-analysis of randomized controlled trials. Wenwei Yang, Shuquan Li, Qingrui Yang. Medicine (Baltimore), 2019 May 18; 98(20). PMID: 31096532 Free PMC article.
PD-L1 is a double-edged sword in colorectal cancer: the prognostic value of PD-L1 depends on the cell type expressing PD-L1. Hsiang-Ling Ho, Teh-Ying Chou, +4 authors, Hao-Wei Teng. less J Cancer Res Clin Oncol, 2019 May 28; 145(7). PMID: 31129768
Endoplasmic reticulum stress enhances the antigen-specific T cell immune responses and therapeutic antitumor effects generated by therapeutic HPV vaccines. Sung Yong Lee, Jee Youn Oh, +5 authors, Chien-Fu Hung. less J Biomed Sci, 2019 May 28; 26(1). PMID: 31133013 Free PMC article.
The safety and tolerability of combined immune checkpoint inhibitors (anti-PD-1/PD-L1 plus anti-CTLA-4): a systematic review and meta-analysis. Lihu Gu, Parikshit Asutosh Khadaroo, +8 authors, Manman Chen. less BMC Cancer, 2019 Jun 12; 19(1). PMID: 31182049 Free PMC article. Systematic Review.
Combination of CTLA-4 and PD-1 blockers for treatment of cancer. Anand Rotte. J Exp Clin Cancer Res, 2019 Jun 15; 38(1). PMID: 31196207 Free PMC article. Highly Cited. Review.
Advances in cancer immunotherapy 2019 - latest trends. Stephan Kruger, Matthias Ilmer, +12 authors, Michael von Bergwelt-Baildon. less J Exp Clin Cancer Res, 2019 Jun 21; 38(1). PMID: 31217020 Free PMC article. Highly Cited. Review.
New emerging targets in cancer immunotherapy: the role of TIM3. Alex Friedlaender, Alfredo Addeo, Giuseppe Banna. ESMO Open, 2019 Jul 06; 4(Suppl 3). PMID: 31275616 Free PMC article. Review.
New emerging targets in cancer immunotherapy beyond CTLA-4, PD-1 and PD-L1: Introducing an "ESMO Open - Cancer Horizons" Series. Matteo Lambertini, Matthias Preusser, Christoph C Zielinski. ESMO Open, 2019 Jul 06; 4(Suppl 3). PMID: 31275617 Free PMC article.
Immune checkpoint inhibitor treatment in patients with oncogene- addicted non-small cell lung cancer (NSCLC): summary of a multidisciplinary round-table discussion. Anna S Berghoff, Beatriz Bellosillo, +8 authors, Christoph C Zielinski. less ESMO Open, 2019 Jul 13; 4(3). PMID: 31297240 Free PMC article. Review.
The overall safety evaluation of programmed cell death/programmed cell death ligand 1 (PD-1/PD-L1) treatment for lung cancer patients: An updated systematic review and meta-analysis. Heli Shang, Zewen Zhang, +7 authors, Yuan Tian. less Medicine (Baltimore), 2019 Jul 28; 98(30). PMID: 31348245 Free PMC article. Systematic Review.
Brain metastases from esophageal cancer: A retrospective analysis of the outcome after surgical resection followed by radiotherapy. Pantelis Stavrinou, Lars Plambeck, +3 authors, Stefan Grau. less Medicine (Baltimore), 2019 Aug 24; 98(34). PMID: 31441840 Free PMC article.
Sites of metastasis and association with clinical outcome in advanced stage cancer patients treated with immunotherapy. Mehmet Asim Bilen, Julie M Shabto, +17 authors, R Donald Harvey. less BMC Cancer, 2019 Aug 30; 19(1). PMID: 31464611 Free PMC article.
Exploring the Pathological Mechanism of Bladder Cancer Based on Tumor Mutational Burden Analysis. Yao Ma, Xiao-Fei Feng, Wan-Xia Yang, Chong-Ge You. Biomed Res Int, 2019 Sep 20; 2019. PMID: 31534952 Free PMC article.
TMB: a promising immune-response biomarker, and potential spearhead in advancing targeted therapy trials. Khalil Choucair, Susan Morand, +3 authors, John Nemunaitis. less Cancer Gene Ther, 2020 Apr 29; 27(12). PMID: 32341410 Review.
Relationship Between Progression-Free Survival, Objective Response Rate, and Overall Survival in Clinical Trials of PD-1/PD-L1 Immune Checkpoint Blockade: A Meta-Analysis. Jiabu Ye, Xiang Ji, +2 authors, Phillip A Dennis, Hesham Abdullah, Pralay Mukhopadhyay. less Clin Pharmacol Ther, 2020 Jun 22; 108(6). PMID: 32564368 Free PMC article. Systematic Review.
Prognostic value of morphological characteristics assessed by CT scan in patients with non-small cell lung cancer treated with nivolumab. Hiroyuki Minemura, Hiroshi Moriya, +12 authors, Yoko Shibata. less Thorac Cancer, 2020 Oct 13; 11(12). PMID: 33044045 Free PMC article.
Tumor Mutational Burden as a Predictive Biomarker in Solid Tumors. Dan Sha, Zhaohui Jin, +3 authors, Frank A Sinicrope. less Cancer Discov, 2020 Nov 04; 10(12). PMID: 33139244 Free PMC article.
Soluble Immune Checkpoints, Gut Metabolites and Performance Status as Parameters of Response to Nivolumab Treatment in NSCLC Patients. Ilaria Grazia Zizzari, Alessandra Di Filippo, +12 authors, Chiara Napoletano. less J Pers Med, 2020 Nov 08; 10(4). PMID: 33158018 Free PMC article.
The interplay between cancer type, panel size and tumor mutational burden threshold in patient selection for cancer immunotherapy. Mahdi Golkaram, Chen Zhao, +2 authors, Kristina Kruglyak, Shile Zhang, Sven Bilke. less PLoS Comput Biol, 2020 Nov 10; 16(11). PMID: 33166276 Free PMC article.
Exploring the Potential Use of a PBMC-Based Functional Assay to Identify Predictive Biomarkers for Anti-PD-1 Immunotherapy. Silvia M Bacot, Taylor A Harper, +6 authors, Gerald M Feldman. less Int J Mol Sci, 2020 Dec 03; 21(23). PMID: 33261003 Free PMC article.
SITC cancer immunotherapy resource document: a compass in the land of biomarker discovery. Siwen Hu-Lieskovan, Srabani Bhaumik, +14 authors, Holden T Maecker. less J Immunother Cancer, 2020 Dec 04; 8(2). PMID: 33268350 Free PMC article.
Clinically relevant prognostic and predictive markers for immune-checkpoint-inhibitor (ICI) therapy in non-small cell lung cancer (NSCLC). Wolfgang M Brueckl, Joachim H Ficker, Gloria Zeitler. BMC Cancer, 2020 Dec 05; 20(1). PMID: 33272262 Free PMC article. Review.
Identification of Prognostic Biomarkers of Cutaneous Melanoma Based on Analysis of Tumor Mutation Burden. Jiaqiong Lin, Yan Lin, Zena Huang, Xiaoyong Li. Comput Math Methods Med, 2020 Dec 05; 2020. PMID: 33273963 Free PMC article.
Changing paradigm in advanced and metastatic non-small cell lung cancer. Dipesh Uprety, Kaushal Parikh, +2 authors, Anita Sawkar, Anastasios Dimou, Konstantinos Leventakos. less J Thorac Dis, 2020 Dec 08; 12(11). PMID: 33282404 Free PMC article. Review.
Intravenous injection of the oncolytic virus M1 awakens antitumor T cells and overcomes resistance to checkpoint blockade. Yang Liu, Jing Cai, +10 authors, Jiankai Liang. less Cell Death Dis, 2020 Dec 15; 11(12). PMID: 33311488 Free PMC article.
Immunotherapy Use in Patients With Lung Cancer and Comorbidities. Mitchell S von Itzstein, Amrit S Gonugunta, +2 authors, Helen G Mayo, John D Minna, David E Gerber. less Cancer J, 2020 Dec 11; 26(6). PMID: 33298724 Free PMC article. Review.
Association Between Immune Checkpoint Inhibitors With Cardiovascular Events and Atherosclerotic Plaque. Zsofia D Drobni, Raza M Alvi, +17 authors, Tomas G Neilan. less Circulation, 2020 Oct 03; 142(24). PMID: 33003973 Free PMC article.
Beyond chemoradiotherapy: improving treatment outcomes for patients with stage III unresectable non-small-cell lung cancer through immuno-oncology and durvalumab (Imfinzi®▼, AstraZeneca UK Limited). Priyanka Patel, Doraid Alrifai, +2 authors, Fiona McDonald, Martin Forster, AstraZeneca UK Limited. less Br J Cancer, 2020 Dec 10; 123(Suppl 1). PMID: 33293672 Free PMC article. Review.
Relationship between tumor mutational burden and maximum standardized uptake value in 2-[18F]FDG PET (positron emission tomography) scan in cancer patients. Amin Haghighat Jahromi, Donald A Barkauskas, +5 authors, Razelle Kurzrock. less EJNMMI Res, 2020 Dec 10; 10(1). PMID: 33296034 Free PMC article.
Imperfect Predictors for Lung Cancer Immunotherapy-A Field for Further Research. Kamila Wojas-Krawczyk, Tomasz Kubiatowski. Front Oncol, 2020 Dec 18; 10. PMID: 33330041 Free PMC article. Review.
Discordance of immunotherapy response predictive biomarkers between primary lesions and paired metastases in tumours: A systematic review and meta-analysis. Yutian Zou, Xiaoqian Hu, +5 authors, Xiaoming Xie. less EBioMedicine, 2020 Dec 15; 63. PMID: 33310681 Free PMC article. Systematic Review.
The Role of Intratumor Heterogeneity in the Response of Metastatic Non-Small Cell Lung Cancer to Immune Checkpoint Inhibitors. Marcin Nicoś, Paweł Krawczyk, Nicola Crosetto, Janusz Milanowski. Front Oncol, 2020 Dec 22; 10. PMID: 33344229 Free PMC article. Review.
Programmed cell death 1 (PD-1)/PD-ligand 1(PD-L1) inhibitors-related pneumonitis in patients with advanced non-small cell lung cancer. Yuxin Sun, Chi Shao, +6 authors, Zuojun Xu. less Asia Pac J Clin Oncol, 2020 Aug 07; 16(6). PMID: 32757454 Free PMC article. Review.
Metabolomics to Assess Response to Immune Checkpoint Inhibitors in Patients with Non-Small-Cell Lung Cancer. Veronica Ghini, Letizia Laera, +6 authors, Daniele Pozzessere. less Cancers (Basel), 2020 Dec 04; 12(12). PMID: 33265926 Free PMC article.
Integrating Circulating Biomarkers in the Immune Checkpoint Inhibitor Treatment in Lung Cancer. Boris Duchemann, Jordi Remon, +10 authors, Nathalie Chaput. less Cancers (Basel), 2020 Dec 09; 12(12). PMID: 33287347 Free PMC article. Review.
Primary and Acquired Resistance to Immunotherapy in Lung Cancer: Unveiling the Mechanisms Underlying of Immune Checkpoint Blockade Therapy. Laura Boyero, Amparo Sánchez-Gastaldo, +3 authors, Reyes Bernabé-Caro. less Cancers (Basel), 2020 Dec 17; 12(12). PMID: 33322522 Free PMC article. Review.
The Prognostic Impact of Circulating Tumour DNA in Melanoma Patients Treated with Systemic Therapies-Beyond BRAF Mutant Detection. Gabriela Marsavela, Peter A Johansson, +12 authors, Leslie Calapre. less Cancers (Basel), 2020 Dec 20; 12(12). PMID: 33339135 Free PMC article.
Evolving Role of Immunotherapy in Metastatic Castration Refractory Prostate Cancer. Nityam Rathi, Taylor Ryan McFarland, +2 authors, Roberto Nussenzveig, Neeraj Agarwal, Umang Swami. less Drugs, 2020 Dec 29; 81(2). PMID: 33369720 Free PMC article. Review.
Development and Preliminary Clinical Activity of PD-1-Guided CTLA-4 Blocking Bispecific DART Molecule. Alexey Berezhnoy, Bradley J Sumrow, +16 authors, Paul A Moore. less Cell Rep Med, 2020 Dec 31; 1(9). PMID: 33377134 Free PMC article.
Burden of Proof: Evaluating the Efficacy of Tumor Mutational Burden (TMB) in Predicting Response to Immune Checkpoint Inhibitors. James Newman, Nagashree Seetharamu, Muhammad Wasif Saif. Cancer Med J, 2020 Dec 31; 3(Suppl 2). PMID: 33377136 Free PMC article.
Immunobiology and immunotherapy of HCC: spotlight on innate and innate-like immune cells. Benjamin Ruf, Bernd Heinrich, Tim F Greten. Cell Mol Immunol, 2020 Nov 26; 18(1). PMID: 33235387 Free PMC article. Review.
Choosing PD-1 Inhibitors in Oncology Setting, Left or Right?-Lessons From Value Assessment With ASCO-VF and ESMO-MCBS. Qian Jiang, Mei Feng, +3 authors, Youping Li, Jinyi Lang, Hua Wei, Ting Yu. less Front Pharmacol, 2021 Jan 05; 11. PMID: 33390946 Free PMC article.
LRP1B or TP53 mutations are associated with higher tumor mutational burden and worse survival in hepatocellular carcinoma. Longrong Wang, Kai Yan, +6 authors, Lu Wang. less J Cancer, 2021 Jan 05; 12(1). PMID: 33391418 Free PMC article.
Utilization of circulating cell-free DNA profiling to guide first-line chemotherapy in advanced lung squamous cell carcinoma. Tao Jiang, Liyan Jiang, +41 authors, Caicun Zhou. less Theranostics, 2021 Jan 05; 11(1). PMID: 33391473 Free PMC article.
Improved survival and disease control following pembrolizumab-induced immune-related adverse events in high PD-L1 expressing non-small cell lung cancer with brain metastases. Michael Zhang, Adrian J Rodrigues, +11 authors, Gordon Li. less J Neurooncol, 2021 Jan 09; 152(1). PMID: 33415659 Free PMC article.
Response to nivolumab combining radiotherapy and nimotuzumab in metastatic oral squamous cell carcinoma patient with strong PD-L1 expression: a case report. Xiao Tang, Shiqing Chen, +7 authors, Yue He. less Ann Transl Med, 2020 May 02; 8(6). PMID: 32355846 Free PMC article.
Tumor mutation burden as a biomarker for lung cancer patients treated with pemetrexed and cisplatin (the JIPANG-TR). Kazuko Sakai, Masahiro Tsuboi, +25 authors, Kazuto Nishio. less Cancer Sci, 2020 Nov 14; 112(1). PMID: 33185928 Free PMC article.
The implications of clinical risk factors, CAR index, and compositional changes of immune cells on hyperprogressive disease in non-small cell lung cancer patients receiving immunotherapy. Seo Ree Kim, Sang Hoon Chun, +10 authors, Jin Hyoung Kang. less BMC Cancer, 2021 Jan 07; 21(1). PMID: 33402127 Free PMC article.
Blood-based kinase activity profiling: a potential predictor of response to immune checkpoint inhibition in metastatic cancer. Daan P Hurkmans, Els M E Verdegaal, +18 authors, Sjoerd H van der Burg. less J Immunother Cancer, 2021 Jan 12; 8(2). PMID: 33427690 Free PMC article.
Targeting metastatic cancer. Karuna Ganesh, Joan Massagué. Nat Med, 2021 Jan 15; 27(1). PMID: 33442008 Free PMC article. Review.
[Research Progress in the Treatment of Brain Metastases  from Non-small Cell Lung Cancer]. Xue Han, Hongmei Li. Zhongguo Fei Ai Za Zhi, 2020 Dec 29; 23(12). PMID: 33357316 Free PMC article. Review.
Behind a personalized therapy with immune check-point inhibitors in metastatic bladder cancer: ready for a primetime? Sławomir Poletajew, Wojciech Krajewski, Piotr Kryst. Transl Androl Urol, 2021 Jan 19; 9(6). PMID: 33457220 Free PMC article.
NOTCH3 is a Prognostic Factor and Is Correlated With Immune Tolerance in Gastric Cancer. Yuehong Cui, Qian Li, +9 authors, Tianshu Liu. less Front Oncol, 2021 Jan 23; 10. PMID: 33479597 Free PMC article.
Comparative incidence of immune-related adverse events and hyperprogressive disease in patients with non-small cell lung cancer receiving immune checkpoint inhibitors with and without chemotherapy. Norikazu Matsuo, Koichi Azuma, +4 authors, Tomoaki Hoshino. less Invest New Drugs, 2021 Jan 24; 39(4). PMID: 33483882
Predictive biomarkers for response to immune checkpoint inhibitors in lung cancer: PD-L1 and beyond. Hironori Uruga, Mari Mino-Kenudson. Virchows Arch, 2021 Jan 25; 478(1). PMID: 33486574 Review.
Mechanisms underlying low-clinical responses to PD-1/PD-L1 blocking antibodies in immunotherapy of cancer: a key role of exosomal PD-L1. Zi Yin, Min Yu, +5 authors, Sheng Chen. less J Immunother Cancer, 2021 Jan 22; 9(1). PMID: 33472857 Free PMC article. Review.
Current and future aspects of TIM-3 as biomarker or as potential targeted in non-small cell lung cancer scope: is there a role in clinical practice? Ramon Andrade De Mello, Jin-Hui Zhu, +8 authors, Georgio Antoniou. less Transl Lung Cancer Res, 2021 Jan 26; 9(6). PMID: 33489794 Free PMC article.
Predictive values of genomic variation, tumor mutational burden, and PD-L1 expression in advanced lung squamous cell carcinoma treated with immunotherapy. Yanjun Xu, Hui Li, +5 authors, Yun Fan. less Transl Lung Cancer Res, 2021 Jan 26; 9(6). PMID: 33489799 Free PMC article.
Expert consensus on neoadjuvant immunotherapy for non-small cell lung cancer. Wenhua Liang, Kaican Cai, +42 authors, Jianxing He. less Transl Lung Cancer Res, 2021 Jan 26; 9(6). PMID: 33489828 Free PMC article. Review.
Alterations of DNA damage repair in cancer: from mechanisms to applications. Minlin Jiang, Keyi Jia, +7 authors, Caicun Zhou. less Ann Transl Med, 2021 Jan 26; 8(24). PMID: 33490197 Free PMC article. Review.
miRNA-Based Feature Classifier Is Associated with Tumor Mutational Burden in Head and Neck Squamous Cell Carcinoma. Yu Xia, Qi Wang, +4 authors, Xiaofeng Duan. less Biomed Res Int, 2021 Jan 26; 2020. PMID: 33490233 Free PMC article.
Identification of an Immunologic Signature of Lung Adenocarcinomas Based on Genome-Wide Immune Expression Profiles. Bo Ling, Guangbin Ye, +3 authors, Qianli Tang. less Front Mol Biosci, 2021 Jan 29; 7. PMID: 33505988 Free PMC article.
Peripheral CD4+ T cell signatures in predicting the responses to anti-PD-1/PD-L1 monotherapy for Chinese advanced non-small cell lung cancer. Liliang Xia, Hui Wang, +12 authors, Ying Wang. less Sci China Life Sci, 2021 Feb 02; 64(10). PMID: 33521853
DNA-protein biomarkers for immunotherapy in the era of precision oncology. Binnari Kim, So Young Kang, Kyoung-Mee Kim. J Pathol Transl Med, 2020 Nov 07; 55(1). PMID: 33153244 Free PMC article. Review.
The cutting-edge progress of immune-checkpoint blockade in lung cancer. Fei Zhou, Meng Qiao, Caicun Zhou. Cell Mol Immunol, 2020 Nov 13; 18(2). PMID: 33177696 Free PMC article. Review.
ADRB1 was identified as a potential biomarker for breast cancer by the co-analysis of tumor mutational burden and immune infiltration. Jia Wang, Xiaolu Zhang, +5 authors, Changgang Sun. less Aging (Albany NY), 2020 Nov 26; 13(1). PMID: 33234738 Free PMC article.
EPHA5 mutations predict survival after immunotherapy in lung adenocarcinoma. Zhiming Chen, Ji Chen, +5 authors, Haitao Ma. less Aging (Albany NY), 2020 Dec 09; 13(1). PMID: 33288738 Free PMC article.
Nivolumab plus ipilimumab versus nivolumab in individuals with treatment-naive programmed death-ligand 1 positive metastatic soft tissue sarcomas: a multicentre retrospective study. Yaolin Chen, Xiangzhen Liu, +4 authors, Pengfei Chen. less BMC Cancer, 2021 Feb 04; 21(1). PMID: 33530966 Free PMC article.
ILT4 inhibition prevents TAM- and dysfunctional T cell-mediated immunosuppression and enhances the efficacy of anti-PD-L1 therapy in NSCLC with EGFR activation. Xiaozheng Chen, Aiqin Gao, +9 authors, Yuping Sun. less Theranostics, 2021 Feb 05; 11(7). PMID: 33537094 Free PMC article.
Treatment patterns and clinical outcomes in patients with advanced non-small cell lung cancer initiating first-line treatment in the US community oncology setting: a real-world retrospective observational study. Eric Nadler, Bhakti Arondekar, +4 authors, Vivek Pawar. less J Cancer Res Clin Oncol, 2020 Dec 03; 147(3). PMID: 33263865 Free PMC article.
Pembrolizumab as a monotherapy or in combination with platinum-based chemotherapy in advanced non-small cell lung cancer with PD-L1 tumor proportion score (TPS) ≥50%: real-world data. Elizabeth Dudnik, Mor Moskovitz, +11 authors, Israel Lung Cancer Group. less Oncoimmunology, 2021 Feb 09; 10(1). PMID: 33552685 Free PMC article.
Identification of Immune-Related lncRNA Signature to Predict Prognosis and Immunotherapeutic Efficiency in Bladder Cancer. Lianghao Zhang, Longqing Li, +3 authors, Xuepei Zhang. less Front Oncol, 2021 Feb 09; 10. PMID: 33552945 Free PMC article.
Prognostic Implications of Pan-Cancer CMTM6 Expression and Its Relationship with the Immune Microenvironment. Yanbin Zhao, Minghui Zhang, +3 authors, Yan Wang. less Front Oncol, 2021 Feb 09; 10. PMID: 33552963 Free PMC article.
Smoking history and the efficacy of immune checkpoint inhibitors in patients with advanced non-small cell lung cancer: a systematic review and meta-analysis. Da-Li Chen, Qing-Yuan Li, Qun-You Tan. J Thorac Dis, 2021 Feb 12; 13(1). PMID: 33569202 Free PMC article.
Surgery after neoadjuvant immunotherapy in patients with resectable non-small cell lung cancer. Caroline Huynh, Logan A Walsh, Jonathan D Spicer. Transl Lung Cancer Res, 2021 Feb 12; 10(1). PMID: 33569337 Free PMC article. Review.
The Challenges of Tumor Mutational Burden as an Immunotherapy Biomarker. Denis L Jardim, Aaron Goodman, Debora de Melo Gagliato, Razelle Kurzrock. Cancer Cell, 2020 Oct 31; 39(2). PMID: 33125859 Free PMC article. Review.
Biomarkers for precision immunotherapy in the metastatic setting: hope or reality? Elham Sajjadi, Konstantinos Venetis, Cristian Scatena, Nicola Fusco. Ecancermedicalscience, 2021 Feb 13; 14. PMID: 33574895 Free PMC article. Review.
A Combined Two-mRNA Signature Associated With PD-L1 and Tumor Mutational Burden for Prognosis of Lung Adenocarcinoma. Congkuan Song, Zhiquan Wu, +4 authors, Weidong Hu. less Front Cell Dev Biol, 2021 Feb 16; 9. PMID: 33585490 Free PMC article.
Laminin γ2-mediating T cell exclusion attenuates response to anti-PD-1 therapy. Lei Li, Jia-Ru Wei, +11 authors, Xin-Yuan Guan. less Sci Adv, 2021 Feb 05; 7(6). PMID: 33536206 Free PMC article.
Comprehensive molecular profiling broadens treatment options for breast cancer patients. Hitomi Kawaji, Makoto Kubo, +16 authors, Masafumi Nakamura. less Cancer Med, 2020 Dec 05; 10(2). PMID: 33274848 Free PMC article.
Immune landscape and a promising immune prognostic model associated with TP53 in early-stage lung adenocarcinoma. Chengde Wu, Xiang Rao, Wei Lin. Cancer Med, 2020 Dec 15; 10(3). PMID: 33314730 Free PMC article.
Identification and Validation of Efficacy of Immunological Therapy for Lung Cancer From Histopathological Images Based on Deep Learning. Yachao Yang, Jialiang Yang, +4 authors, Kaimei Huang. less Front Genet, 2021 Feb 27; 12. PMID: 33633793 Free PMC article.
MicroRNAs Expression Patterns Predict Tumor Mutational Burden in Colorectal Cancer. Jiahao Huang, Haizhou Liu, +5 authors, Weizhong Tang. less Front Oncol, 2021 Feb 27; 10. PMID: 33634010 Free PMC article.
miRNA-Based Therapeutics in the Era of Immune-Checkpoint Inhibitors. Florian Huemer, Michael Leisch, +2 authors, Roland Geisberger, Nadja Zaborsky, Richard Greil. less Pharmaceuticals (Basel), 2021 Feb 04; 14(2). PMID: 33530393 Free PMC article. Review.
Making the Most of Complexity to Create Opportunities: Comprehensive Genomic Profiling and Molecular Tumor Board for Patients with Non-Small Cell Lung Cancer (NSCLC). Caterina Fumagalli, Elena Guerini-Rocco, Massimo Barberis. Cancers (Basel), 2021 Feb 10; 13(4). PMID: 33557047 Free PMC article.
The progress and challenge of anti-PD-1/PD-L1 immunotherapy in treating non-small cell lung cancer. Jingjing Qu, Quanhui Mei, +4 authors, Jianying Zhou. less Ther Adv Med Oncol, 2021 Mar 02; 13. PMID: 33643442 Free PMC article. Review.
Long Non-coding RNA Expression Patterns in Stomach Adenocarcinoma Serve as an Indicator of Tumor Mutation Burden and Are Associated With Tumor-Infiltrating Lymphocytes and Microsatellite Instability. Dongdong Yang, Jinling Yu, +3 authors, Bing Han, Yue Sun, Steven Mo, Jing Hu. less Front Cell Dev Biol, 2021 Mar 02; 9. PMID: 33644056 Free PMC article.
Predictive biomarkers of anti-PD-1/PD-L1 therapy in NSCLC. Mengke Niu, Ming Yi, +2 authors, Ning Li, Suxia Luo, Kongming Wu. less Exp Hematol Oncol, 2021 Mar 04; 10(1). PMID: 33653420 Free PMC article. Review.
Chemotherapy negatively impacts the tumor immune microenvironment in NSCLC: an analysis of pre- and post-treatment biopsies in the multi-center SAKK19/09 study. M A Amrein, E D Bührer, +8 authors, A F Ochsenbein. less Cancer Immunol Immunother, 2020 Aug 09; 70(2). PMID: 32767058 Free PMC article.
A multidisciplinary consensus on the morphological and functional responses to immunotherapy treatment. L Leon-Mateos, M J Garcia-Velloso, +6 authors, L Gorospe. less Clin Transl Oncol, 2020 Jul 06; 23(3). PMID: 32623581 Free PMC article.
Beyond immune checkpoint blockade: emerging immunological strategies. Shawn P Kubli, Thorsten Berger, +2 authors, Daniel V Araujo, Lillian L Siu, Tak W Mak. less Nat Rev Drug Discov, 2021 Mar 10; 20(12). PMID: 33686237 Review.
The Comprehensive Analyses of Genomic Variations and Assessment of TMB and PD-L1 Expression in Chinese Lung Adenosquamous Carcinoma. Yong Cheng, Yanxiang Zhang, +7 authors, Xiaoqun Ye. less Front Genet, 2021 Mar 09; 11. PMID: 33679868 Free PMC article.
Personalized Immuno-Oncology. Kewal K Jain. Med Princ Pract, 2020 Aug 26; 30(1). PMID: 32841942 Free PMC article. Review.
Clinicopathological and molecular characteristics of patients with hypermutant lung cancer: A retrospective cohort study. Hongbin Zhang, Yuan Wang, +11 authors, Min Zhao. less Oncol Lett, 2021 Mar 12; 21(4). PMID: 33692861 Free PMC article.
Recent advances in preclinical models for lung squamous cell carcinoma. Yuanwang Pan, Han Han, +2 authors, Kristen E Labbe, Hua Zhang, Kwok-Kin Wong. less Oncogene, 2021 Mar 13; 40(16). PMID: 33707749 Review.
Harnessing cell-free DNA: plasma circulating tumour DNA for liquid biopsy in genitourinary cancers. Manuel Caitano Maia, Meghan Salgia, Sumanta K Pal. Nat Rev Urol, 2020 Mar 24; 17(5). PMID: 32203306 Review.
Mutational signatures in squamous cell carcinoma of the lung. Atsushi Osoegawa, Kazuki Takada, +8 authors, Masaki Mori. less J Thorac Dis, 2021 Mar 16; 13(2). PMID: 33717580 Free PMC article.
Novel risk scoring system for immune checkpoint inhibitors treatment in non-small cell lung cancer. Chuling Li, Meiqi Shi, +9 authors, Yong Song. less Transl Lung Cancer Res, 2021 Mar 16; 10(2). PMID: 33718021 Free PMC article.
Effectiveness of EGFR-TKI rechallenge immediately after PD-1 blockade failure. Kyoichi Kaira, Kunihiko Kobayashi, +7 authors, Hiroshi Kagamu. less Thorac Cancer, 2021 Feb 02; 12(6). PMID: 33522139 Free PMC article.
Smoking status during first-line immunotherapy and chemotherapy in NSCLC patients: A case-control matched analysis from a large multicenter study. Alessio Cortellini, Andrea De Giglio, +48 authors, Giampiero Porzio. less Thorac Cancer, 2021 Feb 03; 12(6). PMID: 33527756 Free PMC article.
Chemotherapeutic drugs: Cell death- and resistance-related signaling pathways. Are they really as smart as the tumor cells? Mojtaba Mollaei, Zuhair Mohammad Hassan, Fatemeh Khorshidi, Ladan Langroudi. Transl Oncol, 2021 Mar 09; 14(5). PMID: 33684837 Free PMC article. Review.
[Developments in Immunotherapy for Advanced Non-small Cell Lung Cancer]. Haoyang Li, Jinghui Wang. Zhongguo Fei Ai Za Zhi, 2021 Jan 29; 24(2). PMID: 33508897 Free PMC article. Review.
LRP1B mutations are associated with favorable outcomes to immune checkpoint inhibitors across multiple cancer types. Landon C Brown, Matthew D Tucker, +14 authors, Andrew J Armstrong. less J Immunother Cancer, 2021 Mar 04; 9(3). PMID: 33653800 Free PMC article.
Comprehensive Genomic Profiling of Rare Tumors in China: Routes to Immunotherapy. Shuhang Wang, Yuan Fang, +6 authors, Ning Li. less Front Immunol, 2021 Mar 19; 12. PMID: 33732253 Free PMC article.
The Synergistic Effect of PARP Inhibitors and Immune Checkpoint Inhibitors. Zhaozhen Wu, Pengfei Cui, +10 authors, Yi Hu. less Clin Med Insights Oncol, 2021 Mar 20; 15. PMID: 33737855 Free PMC article. Review.
Neoadjuvant immunotherapy in resectable head and neck cancer: oral cavity carcinoma as a potential research model. Vanesa Gutiérrez Calderón, Alexandra Cantero González, +2 authors, Antonio Rueda Domínguez. less Ther Adv Med Oncol, 2021 Mar 23; 13. PMID: 33747147 Free PMC article. Review.
Integration of comprehensive genomic profiling, tumor mutational burden, and PD-L1 expression to identify novel biomarkers of immunotherapy in non-small cell lung cancer. Yunfei Shi, Youming Lei, +8 authors, Qing Zhou. less Cancer Med, 2021 Mar 04; 10(7). PMID: 33655698 Free PMC article.
Advanced Melanoma: Resistance Mechanisms to Current Therapies. Alexandra M Haugh, April K S Salama, Douglas B Johnson. Hematol Oncol Clin North Am, 2021 Mar 25; 35(1). PMID: 33759769 Free PMC article. Review.
Treatment- and immune-related adverse events of immune checkpoint inhibitors in advanced lung cancer. Jun Shao, Chengdi Wang, +3 authors, Weimin Li. less Biosci Rep, 2020 Apr 22; 40(5). PMID: 32315071 Free PMC article. Systematic Review.
Adverse Events Following Administration of Anti-CTLA4 Antibody Ipilimumab. Amirali Karimi, Sanam Alilou, Hamid Reza Mirzaei. Front Oncol, 2021 Mar 27; 11. PMID: 33767992 Free PMC article. Review.
Neoadjuvant chemoradiation alters biomarkers of anticancer immunotherapy responses in locally advanced rectal cancer. Incheol Seo, Hye Won Lee, +6 authors, Sung Uk Bae. less J Immunother Cancer, 2021 Mar 12; 9(3). PMID: 33692216 Free PMC article.
Immune-related adverse events and immune checkpoint inhibitor tolerance on rechallenge in patients with irAEs: a single-center experience. Vineel Bhatlapenumarthi, Anannya Patwari, Antoine J Harb. J Cancer Res Clin Oncol, 2021 Mar 29; 147(9). PMID: 33774736
Imaging-based Biomarkers for Predicting and Evaluating Cancer Immunotherapy Response. Minghao Wu, Yanyan Zhang, +3 authors, Yuwei Zhang, Ying Liu, Mingjie Wu, Zhaoxiang Ye. less Radiol Imaging Cancer, 2019 Nov 29; 1(2). PMID: 33778682 Free PMC article. Review.
A view on drug resistance in cancer. Neil Vasan, José Baselga, David M Hyman. Nature, 2019 Nov 15; 575(7782). PMID: 31723286 Free PMC article. Highly Cited. Review.
The impact of ARID1A mutation on molecular characteristics in colorectal cancer. Ryuma Tokunaga, Joanne Xiu, +17 authors, Heinz-Josef Lenz. less Eur J Cancer, 2020 Oct 21; 140. PMID: 33080474 Free PMC article.
Recognizing Prognostic and Predictive Biomarkers in the Treatment of Non-Small Cell Lung Cancer (NSCLC) with Immune Checkpoint Inhibitors (ICIs). Nicholas Giustini, Lyudmila Bazhenova. Lung Cancer (Auckl), 2021 Apr 02; 12. PMID: 33790679 Free PMC article. Review.
The Predictive Efficacy of Tumor Mutation Burden (TMB) on Nonsmall Cell Lung Cancer Treated by Immune Checkpoint Inhibitors: A Systematic Review and Meta-Analysis. Zhang Nan, Wang Guoqing, +4 authors, Yu Xiaoxu, Mi Yin, He Xin, Li Xue, Wang Rong. less Biomed Res Int, 2021 Apr 02; 2021. PMID: 33791360 Free PMC article. Systematic Review.
Myeloid cell heterogeneity in lung cancer: implication for immunotherapy. Sabina Sangaletti, Roberto Ferrara, +2 authors, Mario Paolo Colombo. less Cancer Immunol Immunother, 2021 Apr 03; 70(9). PMID: 33797567 Free PMC article. Review.
Nivolumab plus ipilimumab, with or without enzalutamide, in AR-V7-expressing metastatic castration-resistant prostate cancer: A phase-2 nonrandomized clinical trial. Eugene Shenderov, Karim Boudadi, +14 authors, Emmanuel S Antonarakis. less Prostate, 2021 Feb 27; 81(6). PMID: 33636027 Free PMC article.
Imaging Biomarkers to Predict and Evaluate the Effectiveness of Immunotherapy in Advanced Non-Small-Cell Lung Cancer. Ying Liu, Minghao Wu, +15 authors, Zhaoxiang Ye. less Front Oncol, 2021 Apr 06; 11. PMID: 33816314 Free PMC article.
Tumour neoantigen mimicry by microbial species in cancer immunotherapy. Maximilian Boesch, Florent Baty, +4 authors, Martin H Brutsche. less Br J Cancer, 2021 Apr 08; 125(3). PMID: 33824481 Free PMC article. Review.
Does Very Poor Performance Status Systematically Preclude Single Agent Anti-PD-1 Immunotherapy? A Multicenter Study of 35 Consecutive Patients. Valérie Gounant, Michael Duruisseaux, +14 authors, Gérard Zalcman. less Cancers (Basel), 2021 Apr 04; 13(5). PMID: 33801285 Free PMC article.
The Current Landscape of Immune Checkpoint Blockade in Metastatic Lung Squamous Cell Carcinoma. Hong Yuan, Jing Liu, Jun Zhang. Molecules, 2021 Apr 04; 26(5). PMID: 33807509 Free PMC article. Review.
Clinical Application of the FoundationOne CDx Assay to Therapeutic Decision-Making for Patients with Advanced Solid Tumors. Masayuki Takeda, Takayuki Takahama, +21 authors, Kazuto Nishio. less Oncologist, 2020 Dec 17; 26(4). PMID: 33325566 Free PMC article.
Gene expression and immune infiltration in melanoma patients with different mutation burden. Liwei Wang, Fu Chen, +3 authors, Rui Liu, Lei Shi, Guosheng Zhao, Zhengjian Yan. less BMC Cancer, 2021 Apr 11; 21(1). PMID: 33836680 Free PMC article.
Engaging the Innate and Adaptive Antitumor Immune Response in Lymphoma. Clifford M Csizmar, Stephen M Ansell. Int J Mol Sci, 2021 Apr 04; 22(7). PMID: 33804869 Free PMC article. Review.
PD-(L)1 Inhibitors as Monotherapy for the First-Line Treatment of Non-Small-Cell Lung Cancer Patients with High PD-L1 Expression: A Network Meta-Analysis. Margarita Majem, Manuel Cobo, +9 authors, Luis Paz-Ares. less J Clin Med, 2021 Apr 04; 10(7). PMID: 33810441 Free PMC article. Review.
Panels and models for accurate prediction of tumor mutation burden in tumor samples. Elizabeth Martínez-Pérez, Miguel Angel Molina-Vila, Cristina Marino-Buslje. NPJ Precis Oncol, 2021 Apr 15; 5(1). PMID: 33850256 Free PMC article.
COL1A1 is a prognostic biomarker and correlated with immune infiltrates in lung cancer. Qishun Geng, Zhibo Shen, Lifeng Li, Jie Zhao. PeerJ, 2021 Apr 15; 9. PMID: 33850663 Free PMC article.
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Immunotherapy in nonsmall-cell lung cancer: current status and future prospects for liquid biopsy. Elena María Brozos-Vázquez, Roberto Díaz-Peña, +4 authors, Rafael López-López. less Cancer Immunol Immunother, 2020 Oct 29; 70(5). PMID: 33113004 Review.
Low-dose ipilimumab plus nivolumab combined with IL-2 and hyperthermia in cancer patients with advanced disease: exploratory findings of a case series of 131 stage IV cancers - a retrospective study of a single institution. R Kleef, R Nagy, +7 authors, T Bakacs. less Cancer Immunol Immunother, 2020 Nov 06; 70(5). PMID: 33151369 Free PMC article.
A novel panel based on immune infiltration and tumor mutational burden for prognostic prediction in hepatocellular carcinoma. Chan Xie, Hewei Wu, +6 authors, Liang Peng. less Aging (Albany NY), 2021 Mar 14; 13(6). PMID: 33714200 Free PMC article.
Early plasma circulating tumor DNA (ctDNA) changes predict response to first-line pembrolizumab-based therapy in non-small cell lung cancer (NSCLC). Biagio Ricciuti, Greg Jones, +8 authors, Mark Awad. less J Immunother Cancer, 2021 Mar 28; 9(3). PMID: 33771889 Free PMC article.
Identification of important genes and drug repurposing based on clinical-centered analysis across human cancers. Ying Li, Ya-Ping Dong, +4 authors, Hong-Yang Wang. less Acta Pharmacol Sin, 2020 Jun 20; 42(2). PMID: 32555508 Free PMC article.
Effect of prior therapy on tumor mutational burden in NSCLC. Sushma Jonna, Ari Vanderwalde, +5 authors, Stephen V Liu. less Transl Lung Cancer Res, 2021 Apr 24; 10(3). PMID: 33889505 Free PMC article.
Next-Generation Sequencing Reveals High Uncommon EGFR Mutations and Tumour Mutation Burden in a Subgroup of Lung Cancer Patients. Gang Guo, Gaofeng Li, +6 authors, Yunfei Shi. less Front Oncol, 2021 Apr 24; 11. PMID: 33889543 Free PMC article.
Is immunotherapy in the future of therapeutic management of sarcomas? Ottavia Clemente, Alessandro Ottaiano, +9 authors, Salvatore Tafuto. less J Transl Med, 2021 Apr 28; 19(1). PMID: 33902630 Free PMC article. Review.
Prognostication of a 13-immune-related-gene signature in patients with early triple-negative breast cancer. Ji-Yeon Kim, Hae Hyun Jung, +9 authors, Young-Hyuck Im. less Breast Cancer Res Treat, 2020 Aug 20; 184(2). PMID: 32812178
The Clinical Implications of Tumor Mutational Burden in Osteosarcoma. Lu Xie, Yufei Yang, +9 authors, Xiaodong Tang. less Front Oncol, 2021 Apr 27; 10. PMID: 33898301 Free PMC article.
Nivolumab and Ipilimumab as Maintenance Therapy in Extensive-Disease Small-Cell Lung Cancer: CheckMate 451. Taofeek K Owonikoko, Keunchil Park, +22 authors, Hye Ryun Kim. less J Clin Oncol, 2021 Mar 09; 39(12). PMID: 33683919 Free PMC article.
A five-m6A regulatory gene signature is a prognostic biomarker in lung adenocarcinoma patients. Xiao Wu, Hongxu Sheng, +5 authors, Jian Hu. less Aging (Albany NY), 2021 Apr 03; 13(7). PMID: 33795529 Free PMC article.
Future Perspectives in Detecting EGFR and ALK Gene Alterations in Liquid Biopsies of Patients with NSCLC. Daniela Ferreira, Juliana Miranda, +2 authors, Paula Martins-Lopes, Filomena Adega, Raquel Chaves. less Int J Mol Sci, 2021 May 01; 22(8). PMID: 33916986 Free PMC article. Review.
Circulating Biomarkers of Response and Toxicity of Immunotherapy in Advanced Non-Small Cell Lung Cancer (NSCLC): A Comprehensive Review. Alice Indini, Erika Rijavec, Francesco Grossi. Cancers (Basel), 2021 May 01; 13(8). PMID: 33918661 Free PMC article. Review.
Response Efficacy of PD-1 and PD-L1 Inhibitors in Clinical Trials: A Systematic Review and Meta-Analysis. Shixue Chen, Zhibo Zhang, +11 authors, Yi Hu. less Front Oncol, 2021 May 04; 11. PMID: 33937012 Free PMC article. Systematic Review.
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Immunotherapy-related toxicity in lung cancer: clinical characteristics and managing strategy. Wen-Xin Luo, Lan Yang, Wei-Min Li. Chin Med J (Engl), 2021 Jan 08; 134(7). PMID: 33410615 Free PMC article.
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Prognostic analysis of tumor mutation burden and immune infiltration in hepatocellular carcinoma based on TCGA data. Shaoqing Liu, Qianjie Tang, +8 authors, Xu He. less Aging (Albany NY), 2021 Apr 07; 13(8). PMID: 33820866 Free PMC article.
Tumor Mutation Burden and Immune Invasion Characteristics in Triple Negative Breast Cancer: Genome High-Throughput Data Analysis. Chundi Gao, Huayao Li, +6 authors, Changgang Sun. less Front Immunol, 2021 May 11; 12. PMID: 33968045 Free PMC article.
Immune Checkpoint Inhibitor Associated Hepatotoxicity in Primary Liver Cancer Versus Other Cancers: A Systematic Review and Meta-Analysis. Jianyang Fu, Wang-Zhong Li, +4 authors, Changqing Xie. less Front Oncol, 2021 May 11; 11. PMID: 33968750 Free PMC article. Systematic Review.
Metastatic Renal Cell Carcinoma Management: From Molecular Mechanism to Clinical Practice. Michela Roberto, Andrea Botticelli, +9 authors, Paolo Marchetti. less Front Oncol, 2021 May 11; 11. PMID: 33968762 Free PMC article. Review.
Single or combined immune checkpoint inhibitors compared to first-line platinum-based chemotherapy with or without bevacizumab for people with advanced non-small cell lung cancer. Roberto Ferrara, Martina Imbimbo, +4 authors, Virginie Westeel. less Cochrane Database Syst Rev, 2020 Dec 15; 12. PMID: 33316104 Free PMC article. Systematic Review.
Single or combined immune checkpoint inhibitors compared to first-line platinum-based chemotherapy with or without bevacizumab for people with advanced non-small cell lung cancer. Roberto Ferrara, Martina Imbimbo, +4 authors, Virginie Westeel. less Cochrane Database Syst Rev, 2021 May 01; 4. PMID: 33930176 Free PMC article. Systematic Review.
Tumor Mutation Burden and Differentially Mutated Genes Among Immune Phenotypes in Patients with Lung Adenocarcinoma. Hao Wang, Shanhao Chen, +16 authors, Caicun Zhou. less Onco Targets Ther, 2021 May 13; 14. PMID: 33976553 Free PMC article.
Tumor-Intrinsic Mechanisms Regulating Immune Exclusion in Liver Cancers. Katherine E Lindblad, Marina Ruiz de Galarreta, Amaia Lujambio. Front Immunol, 2021 May 14; 12. PMID: 33981303 Free PMC article. Review.
Identifying Genomic Alterations in Small Cell Lung Cancer Using the Liquid Biopsy of Bronchial Washing Fluid. Jinfang Zhai, Songyan Han, +15 authors, Weihua Yang. less Front Oncol, 2021 May 15; 11. PMID: 33987084 Free PMC article.
Analysis of tumor mutation burden combined with immune infiltrates in endometrial cancer. Jun Zhang, Lanfen An, +2 authors, Xing Zhou, Rui Shi, Hongbo Wang. less Ann Transl Med, 2021 May 15; 9(7). PMID: 33987249 Free PMC article.
The Evolution of STING Signaling and Its Involvement in Cancer. Nimi Vashi, Samuel F Bakhoum. Trends Biochem Sci, 2021 Jan 20; 46(6). PMID: 33461879 Free PMC article. Review.
Response to Standard Therapies and Comprehensive Genomic Analysis for Patients with Lung Adenocarcinoma with EGFR Exon 20 Insertions. Noura J Choudhury, Adam J Schoenfeld, +9 authors, Gregory J Riely. less Clin Cancer Res, 2021 Mar 10; 27(10). PMID: 33685865 Free PMC article.
The prognostic impact of tumor mutational burden (TMB) in the first-line management of advanced non-oncogene addicted non-small-cell lung cancer (NSCLC): a systematic review and meta-analysis of randomized controlled trials. A Galvano, V Gristina, +9 authors, V Bazan. less ESMO Open, 2021 May 04; 6(3). PMID: 33940346 Free PMC article. Systematic Review.
Pan-cancer methylation analysis reveals an inverse correlation of tumor immunogenicity with methylation aberrancy. Changhee Park, Kyeonghun Jeong, +14 authors, Dae Seog Heo. less Cancer Immunol Immunother, 2020 Nov 25; 70(6). PMID: 33230567
From CheckMate 227 to CheckMate 9LA: rethinking the status of chemotherapy in the immunotherapy era-chemo-free or chemo-reform? Haiyi Deng, Chengzhi Zhou. Transl Lung Cancer Res, 2021 May 21; 10(4). PMID: 34012802 Free PMC article.
Tumor mutational burden assessment in non-small-cell lung cancer samples: results from the TMB2 harmonization project comparing three NGS panels. Javier Ramos-Paradas, Susana Hernández-Prieto, +17 authors, Luis Paz-Ares. less J Immunother Cancer, 2021 May 09; 9(5). PMID: 33963008 Free PMC article.
Clinical Insights Into Novel Immune Checkpoint Inhibitors. Jii Bum Lee, Sang-Jun Ha, Hye Ryun Kim. Front Pharmacol, 2021 May 25; 12. PMID: 34025438 Free PMC article. Review.
Immunotherapy in non-small cell lung cancer: advancements and challenges. Fei Zhou, Cai-Cun Zhou. Chin Med J (Engl), 2021 Feb 18; 134(10). PMID: 33595975 Free PMC article.
MiRNA-based model for predicting the TMB level in colon adenocarcinoma based on a LASSO logistic regression method. Zhengtian Li, Lingling Jiang, +5 authors, Gang Du. less Medicine (Baltimore), 2021 May 26; 100(21). PMID: 34032736 Free PMC article.
Combining a Universal Telomerase Based Cancer Vaccine With Ipilimumab in Patients With Metastatic Melanoma - Five-Year Follow Up of a Phase I/IIa Trial. Elin Aamdal, Else Marit Inderberg, +10 authors, Gustav Gaudernack. less Front Immunol, 2021 May 29; 12. PMID: 34046035 Free PMC article.
Treatment-Related Serious Adverse Events of Immune Checkpoint Inhibitors in Clinical Trials: A Systematic Review. Tao Ouyang, Yanyan Cao, +7 authors, Chuansheng Zheng. less Front Oncol, 2021 May 29; 11. PMID: 34046338 Free PMC article. Systematic Review.
Molecular characterization of ctDNA from Chinese patients with advanced gastric adenocarcinoma reveals actionable alterations for targeted and immune therapy. Meng Zhang, Changsong Qi, +8 authors, Jiafu Ji. less J Mol Med (Berl), 2021 Jun 01; 99(9). PMID: 34057552
Nivolumab in Patients with Advanced Platinum-resistant Urothelial Carcinoma: Efficacy, Safety, and Biomarker Analyses with Extended Follow-up from CheckMate 275. Matthew D Galsky, Abdel Saci, +6 authors, Padmanee Sharma. less Clin Cancer Res, 2020 Jun 14; 26(19). PMID: 32532789 Free PMC article.
Blood Tumor Mutational Burden as a Predictive Biomarker in Patients With Advanced Non-Small Cell Lung Cancer (NSCLC). Yuhui Ma, Quan Li, +8 authors, Yongchun Zhou. less Front Oncol, 2021 Jun 01; 11. PMID: 34055609 Free PMC article.
Genomic profiling of advanced cervical cancer to predict response to programmed death-1 inhibitor combination therapy: a secondary analysis of the CLAP trial. Xin Huang, Minjun He, +9 authors, Chunyan Lan. less J Immunother Cancer, 2021 May 21; 9(5). PMID: 34011535 Free PMC article.
Overview of Lung Cancer Immunotherapy. Miguel F Sanmamed, Iñaki Eguren-Santamaria, Kurt A Schalper. Cancer J, 2020 Dec 11; 26(6). PMID: 33298718 Free PMC article. Review.
Prognostic and Predictive Factors in Advanced Head and Neck Squamous Cell Carcinoma. Teresa Magnes, Sandro Wagner, +4 authors, Thomas Melchardt. less Int J Mol Sci, 2021 Jun 03; 22(9). PMID: 34067112 Free PMC article. Review.
Liquid biopsy for therapy monitoring in early-stage non-small cell lung cancer. Misako Nagasaka, Mohammed Hafiz Uddin, +4 authors, Asfar S Azmi. less Mol Cancer, 2021 Jun 03; 20(1). PMID: 34074295 Free PMC article. Review.
Fibrinogen-Albumin Ratio Index (FARI) as a Certain Prognostic Biomarker in Pretreated Patients with Immunotherapy. Ziwei Guo, Jun Liang. Cancer Manag Res, 2021 Jun 04; 13. PMID: 34079370 Free PMC article.
Simple parameters to solve a complex issue: predicting response to checkpoint inhibitor therapy in lung cancer. James Newman, Isabel Preeshagul, +2 authors, Nina Kohn, Craig Devoe, Nagashree Seetharamu. less Lung Cancer Manag, 2021 Jun 05; 10(2). PMID: 34084210 Free PMC article.
Immune-related genes and gene sets for predicting the response to anti-programmed death 1 therapy in patients with primary or metastatic non-small cell lung cancer. Bolin Chen, Min Yang, +7 authors, Liyu Liu. less Oncol Lett, 2021 Jun 05; 22(1). PMID: 34084219 Free PMC article.
Challenges in bioinformatics approaches to tumor mutation burden analysis. Francesca Fenizia, Raffaella Pasquale, +7 authors, Nicola Normanno. less Oncol Lett, 2021 Jun 05; 22(1). PMID: 34084222 Free PMC article.
A risk model developed based on tumor microenvironment predicts overall survival and associates with tumor immunity of patients with lung adenocarcinoma. Jie Wu, Lan Li, +4 authors, Bin Xu. less Oncogene, 2021 Jun 11; 40(26). PMID: 34108619
Chemotherapy Knowledge Base Management in the Era of Precision Oncology. Samuel M Rubinstein, Tarsheen Sethi, +5 authors, Jeremy L Warner. less JCO Clin Cancer Inform, 2021 Jan 08; 5. PMID: 33411619 Free PMC article.
Selection of optimal first-line immuno-related therapy based on specific pathological characteristics for patients with advanced driver-gene wild-type non-small cell lung cancer: a systematic review and network meta-analysis. Lei Sheng, Jing Gao, +5 authors, Lian Liu. less Ther Adv Med Oncol, 2021 Jun 10; 13. PMID: 34104227 Free PMC article. Review.
Immunotherapy in non-small cell lung cancer: Update and new insights. Xabier Mielgo-Rubio, Eider Azkona Uribelarrea, Laura Quintanta Cortés, María Sereno Moyano. J Clin Transl Res, 2021 Jun 10; 7(1). PMID: 34104805 Free PMC article. Review.
Assessment of the Clinical Trials Safety Profile of PD-1/PD-L1 Inhibitors Among Patients With Cancer: An Updated Systematic Review and Meta-Analysis. Yuan Tian, Alan Huang, +4 authors, Yuping Sun. less Front Oncol, 2021 Jun 11; 11. PMID: 34109117 Free PMC article. Systematic Review.
Immunotherapy in Treating EGFR-Mutant Lung Cancer: Current Challenges and New Strategies. Kenneth K W To, Winnie Fong, William C S Cho. Front Oncol, 2021 Jun 12; 11. PMID: 34113560 Free PMC article. Review.
AR Splicing Variants and Resistance to AR Targeting Agents. Mayuko Kanayama, Changxue Lu, Jun Luo, Emmanuel S Antonarakis. Cancers (Basel), 2021 Jun 03; 13(11). PMID: 34071114 Free PMC article. Review.
T cell-inflamed phenotype and increased Foxp3 expression in infiltrating T-cells of mismatch-repair deficient endometrial cancers. Shiho Asaka, Ting-Tai Yen, +2 authors, Tian-Li Wang, Ie-Ming Shih, Stephanie Gaillard. less Mod Pathol, 2018 Nov 08; 32(4). PMID: 30401949 Free PMC article.
Immune Checkpoint Inhibitor-Associated Pneumonitis in Non-Small Cell Lung Cancer: Current Understanding in Characteristics, Diagnosis, and Management. Qin Zhang, Liansha Tang, +2 authors, Yuwen Zhou, Wenbo He, Weimin Li. less Front Immunol, 2021 Jun 15; 12. PMID: 34122422 Free PMC article. Review.
Case Report: Circulating Myeloid-Derived Suppressive-Like Cells and Exhausted Immune Cells in Non-Small Cell Lung Cancer Patients Treated With Three Immune Checkpoint Inhibitors. Giuseppe Bronte, Alberto Verlicchi, +9 authors, Lucio Crinò. less Front Immunol, 2021 Jun 15; 12. PMID: 34122429 Free PMC article.
USP22 deficiency in melanoma mediates resistance to T cells through IFNγ-JAK1-STAT1 signal axis. Min Li, Yanqin Xu, +6 authors, Xuanming Yang. less Mol Ther, 2021 Feb 19; 29(6). PMID: 33601053 Free PMC article.
Immunotherapy in endometrial cancer: rationale, practice and perspectives. Wenyu Cao, Xinyue Ma, +3 authors, Qing Zhang. less Biomark Res, 2021 Jun 18; 9(1). PMID: 34134781 Free PMC article. Review.
Exploration of the Tumor-Suppressive Immune Microenvironment by Integrated Analysis in EGFR-Mutant Lung Adenocarcinoma. Teng Li, Xiaocong Pang, +5 authors, Junling Li. less Front Oncol, 2021 Jun 18; 11. PMID: 34136375 Free PMC article.
Why MUC16 mutations lead to a better prognosis: A study based on The Cancer Genome Atlas gastric cancer cohort. Yu-Jie Huang, Zhi-Fei Cao, +6 authors, Zi-Xiang Zhang. less World J Clin Cases, 2021 Jun 19; 9(17). PMID: 34141777 Free PMC article.
Low Infiltration of CD8+ PD-L1+ T Cells and M2 Macrophages Predicts Improved Clinical Outcomes After Immune Checkpoint Inhibitor Therapy in Non-Small Cell Lung Carcinoma. Liuning Li, Guojie Lu, +5 authors, Lin Yang. less Front Oncol, 2021 Jun 22; 11. PMID: 34150625 Free PMC article.
Epigenetic landscape of small cell lung cancer: small image of a giant recalcitrant disease. Parvez Khan, Jawed Akhtar Siddiqui, +6 authors, Mohd Wasim Nasser. less Semin Cancer Biol, 2020 Nov 22; 83. PMID: 33220460 Free PMC article. Review.
Clinical benefits of precision medicine in treating solid cancers: European Society of Medical Oncology-Magnitude of Clinical Benefit Scale score-based analysis. Y Hibino, M Ito, T Satake, S Kondo. ESMO Open, 2021 Jun 13; 6(4). PMID: 34118770 Free PMC article.
Prognostic value of tumor mutational burden in patients with oral cavity squamous cell carcinoma treated with upfront surgery. A Moreira, A Poulet, +25 authors, M Kamal. less ESMO Open, 2021 Jun 13; 6(4). PMID: 34118772 Free PMC article.
Development and validation of an individualized immune prognostic model in stage I-III lung squamous cell carcinoma. Qi-Fan Yang, Di Wu, +5 authors, Li Liu. less Sci Rep, 2021 Jun 18; 11(1). PMID: 34135424 Free PMC article.
Paired analysis of tumor mutation burden for lung adenocarcinoma and associated idiopathic pulmonary fibrosis. Yasuto Yoneshima, Eiji Iwama, +9 authors, Isamu Okamoto. less Sci Rep, 2021 Jun 19; 11(1). PMID: 34140559 Free PMC article.
Predictability of early changes in derived neutrophil-to-lymphocyte ratio and neutrophil-to-lymphocyte ratio in patients with advanced non-small cell lung cancer treated with immune checkpoint inhibitors. Jeong Uk Lim, Hye Seon Kang, +5 authors, Sang Haak Lee. less J Thorac Dis, 2021 Jun 25; 13(5). PMID: 34164174 Free PMC article.
Liquid biopsy in non-small cell lung cancer-current status and future outlook-a narrative review. Elisabeth Smolle, Valentin Taucher, +2 authors, Jörg Lindenmann, Martin Pichler, Freyja-Maria Smolle-Juettner. less Transl Lung Cancer Res, 2021 Jun 25; 10(5). PMID: 34164273 Free PMC article. Review.
Selecting the optimal immunotherapy regimen in driver-negative metastatic NSCLC. Michael J Grant, Roy S Herbst, Sarah B Goldberg. Nat Rev Clin Oncol, 2021 Jun 26; 18(10). PMID: 34168333 Review.
Prognostic value of CCR2 as an immune indicator in lung adenocarcinoma: A study based on tumor-infiltrating immune cell analysis. Yi Wan, Xin Wang, +8 authors, Li Zhang. less Cancer Med, 2021 May 06; 10(12). PMID: 33949150 Free PMC article.
Anti-PD-1 elicits regression of undifferentiated pleomorphic sarcomas with UV-mutation signatures. Laurene S Cheung, Lingling Chen, +14 authors, Nicolas Llosa. less J Immunother Cancer, 2021 Jun 10; 9(6). PMID: 34103354 Free PMC article.
Sex-related differences in the efficacy of immune checkpoint inhibitors in malignancy: a systematic review and meta-analysis. Li-Ting Lai, Wei-Guo Gu, +5 authors, Chun-Liang Wang. less Aging (Albany NY), 2021 Jun 05; 13(11). PMID: 34086601 Free PMC article. Systematic Review.
Optimizing palliative chemotherapy for advanced invasive mucinous adenocarcinoma of the lung. Yoon Jung Jang, Dong-Gon Hyun, +6 authors, Jae Cheol Lee. less BMC Cancer, 2021 Jun 28; 21(1). PMID: 34174841 Free PMC article.
Ipilimumab and Pembrolizumab Mixed Response in a 41-Year-Old Patient with SMARCA4-Deficient Thoracic Sarcoma: An Interdisciplinary Case Study. Nina Anžič, Fatime Krasniqi, +2 authors, Jasmin Dionne Haslbauer. less Case Rep Oncol, 2021 Jun 29; 14(2). PMID: 34177520 Free PMC article.
Immune Checkpoint Inhibitors-Related Thyroid Dysfunction: Epidemiology, Clinical Presentation, Possible Pathogenesis, and Management. Ling Zhan, Hong-Fang Feng, +4 authors, Sheng-Rong Sun. less Front Endocrinol (Lausanne), 2021 Jun 29; 12. PMID: 34177799 Free PMC article. Systematic Review.
Immune Checkpoint and Anti-Angiogenic Antibodies for the Treatment of Non-Small Cell Lung Cancer in the European Union and United States. Marion Ferreira, Thomas Secher, Nathalie Heuze-Vourc'H, Karen L Reckamp. Pharmaceutics, 2021 Jul 03; 13(6). PMID: 34205484 Free PMC article. Review.
Response Prediction and Evaluation Using PET in Patients with Solid Tumors Treated with Immunotherapy. Frank J Borm, Jasper Smit, +4 authors, Adrianus J de Langen. less Cancers (Basel), 2021 Jul 03; 13(12). PMID: 34205572 Free PMC article. Review.
TMB in NSCLC: A Broken Dream? Sara Bravaccini, Giuseppe Bronte, Paola Ulivi. Int J Mol Sci, 2021 Jul 03; 22(12). PMID: 34207126 Free PMC article. Review.
Classification of Non-Small Cell Lung Cancer's Tumor Immune Micro-Environment and Strategies to Augment Its Response to Immune Checkpoint Blockade. Alexander Chi, Xia He, +4 authors, Jay M Lee. less Cancers (Basel), 2021 Jul 03; 13(12). PMID: 34208113 Free PMC article. Review.
Liquid biopsy as an option for predictive testing and prognosis in patients with lung cancer. Alvida Qvick, Bianca Stenmark, +3 authors, Gisela Helenius. less Mol Med, 2021 Jul 05; 27(1). PMID: 34217228 Free PMC article.
Multi-omics analysis reveals prognostic value of tumor mutation burden in hepatocellular carcinoma. Qianhui Xu, Hao Xu, +5 authors, Wen Huang. less Cancer Cell Int, 2021 Jul 05; 21(1). PMID: 34217320 Free PMC article.
Gut microbiota signatures are associated with toxicity to combined CTLA-4 and PD-1 blockade. Miles C Andrews, Connie P M Duong, +68 authors, Jennifer A Wargo. less Nat Med, 2021 Jul 10; 27(8). PMID: 34239137
Intracerebral administration of CTLA-4 and PD-1 immune checkpoint blocking monoclonal antibodies in patients with recurrent glioblastoma: a phase I clinical trial. Johnny Duerinck, Julia Katharina Schwarze, +18 authors, Bart Neyns. less J Immunother Cancer, 2021 Jun 26; 9(6). PMID: 34168003 Free PMC article.
Incidence risk of PD-1/PD-L1-related pneumonia and diarrhea in non-small cell lung cancer (NSCLC) patients: a systematic review and meta-analysis of randomized controlled trials. Zhi-Qiang Tong, Dong-Yuan Wu, Duo Liu, Mei Dong. Eur J Clin Pharmacol, 2021 Feb 11; 77(8). PMID: 33564898 Systematic Review.
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Microenvironmental regulation of tumour immunity and response to immunotherapy. Mark M Kockx, Mark McCleland, Hartmut Koeppen. J Pathol, 2021 Apr 14; 254(4). PMID: 33846997 Free PMC article. Review.
Analysis of Real-World Data to Investigate the Impact of Race and Ethnicity on Response to Programmed Cell Death-1 and Programmed Cell Death-Ligand 1 Inhibitors in Advanced Non-Small Cell Lung Cancers. Kristin L Ayers, Tommy Mullaney, +22 authors, Rong Chen. less Oncologist, 2021 Apr 09; 26(7). PMID: 33829580 Free PMC article.
Comparative genomic signatures in young and old Chinese patients with colorectal cancer. Fei Wang, Huanqing Cheng, +7 authors, Sheng Dai. less Cancer Med, 2021 May 28; 10(13). PMID: 34041865 Free PMC article.
Tumor mutation score is more powerful than tumor mutation burden in predicting response to immunotherapy in non-small cell lung cancer. Yuan Li, Zuhua Chen, +2 authors, Weiping Tao, Nan Sun, Jie He. less Cancer Immunol Immunother, 2021 Feb 04; 70(8). PMID: 33533944
Tumor-Associated Tertiary Lymphoid Structures: From Basic and Clinical Knowledge to Therapeutic Manipulation. Charlotte Domblides, Juliette Rochefort, +5 authors, Marie-Caroline Dieu-Nosjean. less Front Immunol, 2021 Jul 20; 12. PMID: 34276690 Free PMC article. Review.
Biomarkers of therapeutic response with immune checkpoint inhibitors. Poorva Bindal, Jhanelle E Gray, +2 authors, Theresa A Boyle, Vaia Florou, Sonam Puri. less Ann Transl Med, 2021 Jul 20; 9(12). PMID: 34277840 Free PMC article. Review.
Association of immune-related pneumonitis with clinical benefit of anti-programmed cell death-1 monotherapy in advanced non-small cell lung cancer. Kana Ono, Hirotaka Ono, +19 authors, Shunichi Sugawara. less Cancer Med, 2021 Jun 15; 10(14). PMID: 34121358 Free PMC article.
Unveiling the immune infiltrate modulation in cancer and response to immunotherapy by MIXTURE-an enhanced deconvolution method. Elmer A Fernández, Yamil D Mahmoud, +7 authors, María Romina Girotti. less Brief Bioinform, 2020 Dec 16; 22(4). PMID: 33320931 Free PMC article.
Hyperprogressive Disease in Cancers Treated With Immune Checkpoint Inhibitors. Pan Shen, Liang Han, +2 authors, Xin Ba, Kai Qin, Shenghao Tu. less Front Pharmacol, 2021 Jul 23; 12. PMID: 34290608 Free PMC article. Review.
Impact of cancer cachexia on the therapeutic outcome of combined chemoimmunotherapy in patients with non-small cell lung cancer: a retrospective study. Kenji Morimoto, Junji Uchino, +16 authors, Koichi Takayama. less Oncoimmunology, 2021 Jul 23; 10(1). PMID: 34290909 Free PMC article.
Systematic review of combinations of targeted or immunotherapy in advanced solid tumors. Aaron C Tan, Stephen J Bagley, +18 authors, Mustafa Khasraw. less J Immunother Cancer, 2021 Jul 04; 9(7). PMID: 34215688 Free PMC article. Systematic Review.
Correlation analysis of tumor mutation burden of hepatocellular carcinoma based on data mining. Weijie Zhou, Dalang Fang, Yongfei He, Jie Wei. J Gastrointest Oncol, 2021 Jul 24; 12(3). PMID: 34295561 Free PMC article.
Different prognostic implications of hepatic metastasis according to front-line treatment in non-small cell lung cancer: a real-world retrospective study. Myeong Geun Choi, Chang-Min Choi, +5 authors, Jae Cheol Lee. less Transl Lung Cancer Res, 2021 Jul 24; 10(6). PMID: 34295661 Free PMC article.
International consensus on severe lung cancer-the first edition. Chengzhi Zhou, Shiyue Li, +84 authors, Nanshan Zhong. less Transl Lung Cancer Res, 2021 Jul 24; 10(6). PMID: 34295668 Free PMC article. Review.
Immunotherapy in oncogene addicted non-small cell lung cancer. Luke McLean, Jose Luis Leal, Benjamin J Solomon, Thomas John. Transl Lung Cancer Res, 2021 Jul 24; 10(6). PMID: 34295674 Free PMC article. Review.
Integrating endobronchial ultrasound bronchoscopy with molecular testing of immunotherapy biomarkers in non-small cell lung cancer. Steven Bozinovski, Amanda Vannitamby, +6 authors, Daniel P Steinfort. less Transl Lung Cancer Res, 2021 Jul 24; 10(6). PMID: 34295677 Free PMC article. Review.
Is there any opportunity for immune checkpoint inhibitor therapy in non-small cell lung cancer patients with brain metastases? Lizza E L Hendriks, Jordi Remon, Jessica Menis, Benjamin Besse. Transl Lung Cancer Res, 2021 Jul 24; 10(6). PMID: 34295685 Free PMC article. Review.
Current and future biomarkers for outcomes with immunotherapy in non-small cell lung cancer. Boris Duchemann, Jordi Remon, +8 authors, Nathalie Chaput. less Transl Lung Cancer Res, 2021 Jul 24; 10(6). PMID: 34295689 Free PMC article. Review.
Immunotherapy and Vaccination in Surgically Resectable Non-Small Cell Lung Cancer (NSCLC). Li-Chung Chiu, Shu-Min Lin, +3 authors, Ping-Chih Hsu. less Vaccines (Basel), 2021 Jul 03; 9(7). PMID: 34201650 Free PMC article. Review.
The Impact of NOTCH Pathway Alteration on Tumor Microenvironment and Clinical Survival of Immune Checkpoint Inhibitors in NSCLC. Xiaohua Li, Yuntao Wang, +3 authors, Xuebing Li, Gang Feng, Sheng Hu, Yifeng Bai. less Front Immunol, 2021 Jul 27; 12. PMID: 34305884 Free PMC article.
A Network Meta-Analysis of Cancer Immunotherapies Versus Chemotherapy for First-Line Treatment of Patients With Non-Small Cell Lung Cancer and High Programmed Death-Ligand 1 Expression. Roy Herbst, Jacek Jassem, +5 authors, Filippo De Marinis. less Front Oncol, 2021 Jul 27; 11. PMID: 34307144 Free PMC article. Review.
An N6-Methyladenosine-Related Gene Set Variation Score as a Prognostic Tool for Lung Adenocarcinoma. Huijuan Zhang, Jing Hu, +5 authors, Ping Sun. less Front Cell Dev Biol, 2021 Jul 27; 9. PMID: 34307344 Free PMC article.
The Risk of Immune-Related Thyroid Dysfunction Induced by PD-1/PD-L1 Inhibitors in Cancer Patients: An Updated Systematic Review and Meta-Analysis. Yuan Tian, Ran Li, +7 authors, Yuping Sun. less Front Oncol, 2021 Jul 30; 11. PMID: 34322382 Free PMC article. Systematic Review.
Ovarian Cancer: Therapeutic Strategies to Overcome Immune Suppression. Maureen L Drakes, Patrick J Stiff. Adv Exp Med Biol, 2021 Aug 03; 1330. PMID: 34339029
Multi-Omics Data Integration Analysis of an Immune-Related Gene Signature in LGG Patients With Epilepsy. Quan Cheng, Weiwei Duan, +6 authors, Zhiwei Xia. less Front Cell Dev Biol, 2021 Aug 03; 9. PMID: 34336837 Free PMC article.
The Emerging Importance of Tumor Genomics in Operable Non-Small Cell Lung Cancer. Harry B Lengel, James G Connolly, +9 authors, David R Jones. less Cancers (Basel), 2021 Aug 08; 13(15). PMID: 34359558 Free PMC article. Review.
Cancer Immunotherapies: From Efficacy to Resistance Mechanisms - Not Only Checkpoint Matters. Shuyue Wang, Kun Xie, Tengfei Liu. Front Immunol, 2021 Aug 10; 12. PMID: 34367148 Free PMC article. Review.
Targeting the DNA damage response in immuno-oncology: developments and opportunities. Roman M Chabanon, Mathieu Rouanne, +3 authors, Sophie Postel-Vinay. less Nat Rev Cancer, 2021 Aug 12; 21(11). PMID: 34376827 Review.
Toward personalized treatment approaches for non-small-cell lung cancer. Meina Wang, Roy S Herbst, Chris Boshoff. Nat Med, 2021 Aug 14; 27(8). PMID: 34385702 Review.
The Promises and Challenges of Tumor Mutation Burden as an Immunotherapy Biomarker: A Perspective from the International Association for the Study of Lung Cancer Pathology Committee. Lynette M Sholl, Fred R Hirsch, +35 authors, John W Longshore. less J Thorac Oncol, 2020 Jun 12; 15(9). PMID: 32522712 Free PMC article. Review.
Detection of von Hippel-Lindau gene mutation in circulating cell-free DNA for clear cell renal cell carcinoma. Takayuki Sumiyoshi, Toshinari Yamasaki, +6 authors, Shusuke Akamatsu. less Cancer Sci, 2021 May 20; 112(8). PMID: 34009695 Free PMC article.
Nivolumab monotherapy or combination therapy with ipilimumab for lung cancer: a systemic review and meta-analysis. Huihui Jiang, Aiqun Xu, +6 authors, Ran Wang. less Cancer Cell Int, 2021 Aug 16; 21(1). PMID: 34391428 Free PMC article. Review.
Comparative analysis of machine learning approaches to classify tumor mutation burden in lung adenocarcinoma using histopathology images. Apaar Sadhwani, Huang-Wei Chang, +16 authors, Peter Cimermancic. less Sci Rep, 2021 Aug 18; 11(1). PMID: 34400666 Free PMC article.
TGFBR2 mutation predicts resistance to immune checkpoint inhibitors in patients with non-small cell lung cancer. Teng Li, Han Wang, +8 authors, Zhijie Wang. less Ther Adv Med Oncol, 2021 Aug 20; 13. PMID: 34408796 Free PMC article.
Hypoxia-Related Radiomics and Immunotherapy Response: A Multicohort Study of Non-Small Cell Lung Cancer. Ilke Tunali, Yan Tan, +9 authors, Matthew B Schabath. less JNCI Cancer Spectr, 2021 Aug 20; 5(4). PMID: 34409252 Free PMC article.
Radiomics Study for Predicting the Expression of PD-L1 and Tumor Mutation Burden in Non-Small Cell Lung Cancer Based on CT Images and Clinicopathological Features. Qiang Wen, Zhe Yang, +2 authors, Honghai Dai, Alei Feng, Qiang Li. less Front Oncol, 2021 Aug 24; 11. PMID: 34422625 Free PMC article.
Application of Circulating Tumor DNA as a Biomarker for Non-Small Cell Lung Cancer. Jialiang Yang, Yan Hui, +8 authors, Tonghui Ma. less Front Oncol, 2021 Aug 24; 11. PMID: 34422670 Free PMC article. Review.
Oncogene-specific differences in tumor mutational burden, PD-L1 expression, and outcomes from immunotherapy in non-small cell lung cancer. Marcelo V Negrao, Ferdinandos Skoulidis, +35 authors, John V Heymach. less J Immunother Cancer, 2021 Aug 12; 9(8). PMID: 34376553 Free PMC article.
Is there any place for PD-1/CTLA-4 inhibitors combination in the first-line treatment of advanced NSCLC?-a trial-level meta-analysis in PD-L1 selected subgroups. Francesco Passiglia, Antonio Galvano, +6 authors, Viviana Bazan. less Transl Lung Cancer Res, 2021 Aug 26; 10(7). PMID: 34430351 Free PMC article.
A narrative review of primary research endpoints of neoadjuvant therapy for lung cancer: past, present and future. Sijia Ren, Anyi Xu, +8 authors, Jianfei Shen. less Transl Lung Cancer Res, 2021 Aug 26; 10(7). PMID: 34430363 Free PMC article. Review.
Differential Dermatologic Adverse Events Associated With Checkpoint Inhibitor Monotherapy and Combination Therapy: A Meta-Analysis of Randomized Control Trials. Yang Ge, Huiyun Zhang, Nathaniel Weygant, Jiannan Yao. Front Pharmacol, 2021 Aug 28; 12. PMID: 34447305 Free PMC article.
Digital Image Analysis for Estimating Stromal CD8+ Tumor-Infiltrating Lymphocytes in Lung Adenocarcinoma. Iny Jhun, Daniel Shepherd, +3 authors, Mari Mino-Kenudson. less J Pathol Inform, 2021 Aug 28; 12. PMID: 34447608 Free PMC article.
Lung Cancer Surgery after Neoadjuvant Immunotherapy. Dirk Stefani, Till Plönes, +4 authors, Clemens Aigner. less Cancers (Basel), 2021 Aug 28; 13(16). PMID: 34439187 Free PMC article. Review.
Clinical Utility of Liquid Biopsy-Based Actionable Mutations Detected via ddPCR. Irina Palacín-Aliana, Noemí García-Romero, +3 authors, Ángel Ayuso-Sacido. less Biomedicines, 2021 Aug 28; 9(8). PMID: 34440110 Free PMC article. Review.
Deep Learning of Histopathological Features for the Prediction of Tumour Molecular Genetics. Pierre Murchan, Cathal Ó'Brien, +5 authors, Stephen P Finn. less Diagnostics (Basel), 2021 Aug 28; 11(8). PMID: 34441338 Free PMC article. Review.
Current and Future Development in Lung Cancer Diagnosis. Reem Nooreldeen, Horacio Bach. Int J Mol Sci, 2021 Aug 28; 22(16). PMID: 34445366 Free PMC article. Review.
Immunotherapy Treatment for Triple Negative Breast Cancer. Elizabeth R Berger, Tristen Park, +3 authors, Nita Ahuja. less Pharmaceuticals (Basel), 2021 Aug 29; 14(8). PMID: 34451860 Free PMC article. Review.
Lymphocyte activating gene 3 protein expression in nasopharyngeal carcinoma is correlated with programmed cell death-1 and programmed cell death ligand-1, tumor-infiltrating lymphocytes. Fan Luo, Jiaxin Cao, +5 authors, Hongyun Zhao. less Cancer Cell Int, 2021 Aug 30; 21(1). PMID: 34454491 Free PMC article.
Mutations in the RAS/MAPK Pathway Drive Replication Repair-Deficient Hypermutated Tumors and Confer Sensitivity to MEK Inhibition. Brittany B Campbell, Melissa A Galati, +26 authors, Uri Tabori. less Cancer Discov, 2021 Feb 11; 11(6). PMID: 33563663 Free PMC article.
Real-World Performance of a Comprehensive Genomic Profiling Test Optimized for Small Tumor Samples. Scott A Tomlins, Daniel H Hovelson, +41 authors, Daniel R Rhodes. less JCO Precis Oncol, 2021 Sep 04; 5. PMID: 34476329 Free PMC article.
Comparison of Efficacy and Safety of Single and Double Immune Checkpoint Inhibitor-Based First-Line Treatments for Advanced Driver-Gene Wild-Type Non-Small Cell Lung Cancer: A Systematic Review and Network Meta-Analysis. Qian Xu, Xue Zhang, +7 authors, Lian Liu. less Front Immunol, 2021 Sep 07; 12. PMID: 34484242 Free PMC article. Systematic Review.
Current Status of Immune Checkpoint Inhibitor Immunotherapy for Lung Cancer. Wei Xiong, Yunfeng Zhao, He Du, Xuejun Guo. Front Oncol, 2021 Sep 08; 11. PMID: 34490104 Free PMC article. Review.
Genomic and evolutionary classification of lung cancer in never smokers. Tongwu Zhang, Philippe Joubert, +58 authors, Maria Teresa Landi. less Nat Genet, 2021 Sep 09; 53(9). PMID: 34493867 Free PMC article.
Deciphering the Dynamic Complexities of the Liver Microenvironment - Toward a Better Understanding of Immune-Mediated liver Injury Caused by Immune Checkpoint Inhibitors (ILICI). Tao Wang, Matthew M Yeh, +2 authors, Mark I Avigan, Lorraine Pelosof, Gerald M Feldman. less AAPS J, 2021 Aug 18; 23(5). PMID: 34401948 Review.
Soluble Biomarkers with Prognostic and Predictive Value in Advanced Non-Small Cell Lung Cancer Treated with Immunotherapy. Beatriz Honrubia-Peris, Javier Garde-Noguera, +3 authors, María Leonor Fernández-Murga. less Cancers (Basel), 2021 Sep 11; 13(17). PMID: 34503087 Free PMC article. Review.
Immune Checkpoint Inhibitor-Related Pneumonitis in Lung Cancer: Real-World Incidence, Risk Factors, and Management Practices Across Six Health Care Centers in North Carolina. William T Atchley, Carolina Alvarez, +4 authors, M Patricia Rivera. less Chest, 2021 Feb 24; 160(2). PMID: 33621599 Free PMC article.
Advancing to the era of cancer immunotherapy. Yun Wang, Min Wang, Hao-Xiang Wu, Rui-Hua Xu. Cancer Commun (Lond), 2021 Jun 25; 41(9). PMID: 34165252 Free PMC article. Review.
Towards the understanding of the genetics of somatic mutations. Xiwei Sun, Jian Yang. Br J Cancer, 2021 Apr 09; 125(5). PMID: 33828259 Free PMC article.
Safety, Efficacy, and Pharmacodynamics of Tremelimumab Plus Durvalumab for Patients With Unresectable Hepatocellular Carcinoma: Randomized Expansion of a Phase I/II Study. Robin Kate Kelley, Bruno Sangro, +21 authors, Ghassan K Abou-Alfa. less J Clin Oncol, 2021 Jul 23; 39(27). PMID: 34292792 Free PMC article.
TREM2: Keeping Pace With Immune Checkpoint Inhibitors in Cancer Immunotherapy. Hui Qiu, Zhiying Shao, +6 authors, Longzhen Zhang. less Front Immunol, 2021 Sep 21; 12. PMID: 34539652 Free PMC article. Review.
Three models that predict the efficacy of immunotherapy in Chinese patients with advanced non-small cell lung cancer. Qian Zhao, Butuo Li, +4 authors, Linlin Wang. less Cancer Med, 2021 Aug 15; 10(18). PMID: 34390218 Free PMC article.
Tissue-agnostic drug approvals: how does this apply to patients with breast cancer? Luiza N Weis, Sara M Tolaney, Carlos H Barrios, Romualdo Barroso-Sousa. NPJ Breast Cancer, 2021 Sep 15; 7(1). PMID: 34518552 Free PMC article. Review.
The Immune Landscape of Chinese Head and Neck Adenoid Cystic Carcinoma and Clinical Implication. Shengjin Dou, Rongrong Li, +9 authors, Guopei Zhu. less Front Immunol, 2021 Sep 24; 12. PMID: 34552580 Free PMC article.
Immunotherapy for Head and Neck Cancer: A Paradigm Shift From Induction Chemotherapy to Neoadjuvant Immunotherapy. Hirofumi Shibata, Shin Saito, Ravindra Uppaluri. Front Oncol, 2021 Sep 24; 11. PMID: 34552878 Free PMC article. Review.
New Immunotherapeutic Approaches for Glioblastoma. Gustavo Ignacio Vázquez Cervantes, Dinora F González Esquivel, +2 authors, Saúl Gómez-Manzo, Benjamín Pineda, Verónica Pérez de la Cruz. less J Immunol Res, 2021 Sep 25; 2021. PMID: 34557553 Free PMC article. Review.
FDG PET biomarkers for prediction of survival in metastatic melanoma prior to anti-PD1 immunotherapy. A Flaus, V Habouzit, +5 authors, F Cachin. less Sci Rep, 2021 Sep 24; 11(1). PMID: 34552135 Free PMC article.
Cancer immunotherapy: it's time to better predict patients' response. Charlotte Pilard, Marie Ancion, +3 authors, Michael Herfs. less Br J Cancer, 2021 Jun 12; 125(7). PMID: 34112949 Free PMC article. Review.
NSCLC Biomarkers to Predict Response to Immunotherapy with Checkpoint Inhibitors (ICI): From the Cells to In Vivo Images. Virginia Liberini, Annapaola Mariniello, +7 authors, Désirée Deandreis. less Cancers (Basel), 2021 Sep 29; 13(18). PMID: 34572771 Free PMC article. Review.
PD-L1 Expression Is Significantly Associated with Tumor Mutation Burden and Microsatellite Instability Score. Yoon Ah Cho, Hyunwoo Lee, +5 authors, Kyoung-Mee Kim. less Cancers (Basel), 2021 Sep 29; 13(18). PMID: 34572886 Free PMC article.
From Anti-PD-1/PD-L1 to CTLA-4 and to MUC1-Is the Better Response to Treatment in Smokers of Cancer Patients Drug Specific? Lishi Wang, Fengxia Liu, +13 authors, Jiafu Ji. less J Pers Med, 2021 Sep 29; 11(9). PMID: 34575691 Free PMC article. Review.
Nanobodies Enhancing Cancer Visualization, Diagnosis and Therapeutics. Dhaneshree Bestinee Naidoo, Anil Amichund Chuturgoon. Int J Mol Sci, 2021 Sep 29; 22(18). PMID: 34575943 Free PMC article. Review.
Prognostic Role of ceRNA Network in Immune Infiltration of Hepatocellular Carcinoma. Qianhui Xu, Shaohuai Chen, Yuanbo Hu, Wen Huang. Front Genet, 2021 Oct 01; 12. PMID: 34589117 Free PMC article.
Response to Immune Checkpoint Inhibition as Monotherapy or in Combination With Chemotherapy in Metastatic ROS1-Rearranged Lung Cancers. Noura J Choudhury, Jaime L Schneider, +15 authors, Alexander Drilon. less JTO Clin Res Rep, 2021 Oct 01; 2(7). PMID: 34590036 Free PMC article.
Immune checkpoints and immunotherapy in non-small cell lung cancer: Novel study progression, challenges and solutions. Lin-Rui Ma, Jia-Xin Li, +5 authors, Pei-Yu Yan. less Oncol Lett, 2021 Oct 02; 22(5). PMID: 34594428 Free PMC article. Review.
Pharmacology-based ranking of anti-cancer drugs to guide clinical development of cancer immunotherapy combinations. Vincent Lemaire, Colby S Shemesh, Anand Rotte. J Exp Clin Cancer Res, 2021 Oct 03; 40(1). PMID: 34598713 Free PMC article. Review.
Immune-Related Adverse Events Associated With Outcomes in Patients With NSCLC Treated With Anti-PD-1 Inhibitors: A Systematic Review and Meta-Analysis. Zhe Zhao, Xinfeng Wang, +4 authors, Xiaoguang Chen. less Front Oncol, 2021 Oct 05; 11. PMID: 34604047 Free PMC article. Systematic Review.
DNA Damage Response and Repair Gene Alterations Increase Tumor Mutational Burden and Promote Poor Prognosis of Advanced Lung Cancer. Jiawei Dai, Minlin Jiang, +7 authors, Caicun Zhou. less Front Oncol, 2021 Oct 05; 11. PMID: 34604048 Free PMC article.
Identification and validation of tissue or ctDNA PTPRD phosphatase domain deleterious mutations as prognostic and predictive biomarkers for immune checkpoint inhibitors in non-squamous NSCLC. Yiting Sun, Jianchun Duan, +10 authors, Jie Wang. less BMC Med, 2021 Oct 08; 19(1). PMID: 34615542 Free PMC article.
High-affinity neoantigens correlate with better prognosis and trigger potent antihepatocellular carcinoma (HCC) activity by activating CD39+CD8+ T cells. Ting Liu, Jizhou Tan, +9 authors, Jiaping Li. less Gut, 2020 Dec 03; 70(10). PMID: 33262196 Free PMC article.
Systematic Review of PD-1/PD-L1 Inhibitors in Oncology: From Personalized Medicine to Public Health. Elaine Chang, Lorraine Pelosof, +15 authors, Marc R Theoret. less Oncologist, 2021 Jul 02; 26(10). PMID: 34196068 Free PMC article. Review.
Plasma Cell-Free DNA Genotyping: From an Emerging Concept to a Standard-of-Care Tool in Metastatic Non-Small Cell Lung Cancer. Jhanelle Gray, Jeffrey C Thompson, +2 authors, Erica L Carpenter, Ehab Elkhouly, Charu Aggarwal. less Oncologist, 2021 Jul 04; 26(10). PMID: 34216176 Free PMC article. Review.
Smoking status combined with tumor mutational burden as a prognosis predictor for combination immune checkpoint inhibitor therapy in non-small cell lung cancer. Li-Yue Sun, Wen-Jian Cen, +8 authors, Zi-Ming Du. less Cancer Med, 2021 Sep 02; 10(19). PMID: 34469045 &nb

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