. 2018 Apr; 6:38.
doi: 10.3389/fcell.2018.00038.

Targeting Tumor-Associated Macrophages as a Potential Strategy to Enhance the Response to Immune Checkpoint Inhibitors

Luca Cassetta 1 Takanori Kitamura 1 
  • PMID: 29670880
  •     45 References
  •     75 citations


Inhibition of immune checkpoint pathways in CD8+ T cell is a promising therapeutic strategy for the treatment of solid tumors that has shown significant anti-tumor effects and is now approved by the FDA to treat patients with melanoma and lung cancer. However the response to this therapy is limited to a certain fraction of patients and tumor types, for reasons still unknown. To ensure success of this treatment, CD8+ T cells, the main target of the checkpoint inhibitors, should exert full cytotoxicity against tumor cells. However recent studies show that tumor-associated macrophages (TAM) can impede this process by different mechanisms. In this mini-review we will summarize recent studies showing the effect of TAM targeting on immune checkpoint inhibitors efficacy. We will also discuss on the limitations of the current strategies as well on the future scientific challenges for the progress of the tumor immunology field.

Keywords: CD8+ T cell; TAM; checkpoint inhibitor; immunotherapy; macrophage; tumor immunology; tumor microenvironment.

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Geburtshilfe Frauenheilkd, 2021 Oct 12; 81(10). PMID: 34629492    Free PMC article.
GRP78 facilitates M2 macrophage polarization and tumour progression.
Heng Zhang, Shao-Qiang Wang, +6 authors, Ri Chen.
Cell Mol Life Sci, 2021 Oct 30; 78(23). PMID: 34713304
Effects of dietary omega-3 fatty acids on orthotopic prostate cancer progression, tumor associated macrophages, angiogenesis and T-cell activation-dependence on GPR120.
Pei Liang, Susanne M Henning, +4 authors, William J Aronson.
Prostate Cancer Prostatic Dis, 2022 Jan 26;. PMID: 35075215
Mature tertiary lymphoid structures predict immune checkpoint inhibitor efficacy in solid tumors independently of PD-L1 expression.
Lucile Vanhersecke, Maxime Brunet, +30 authors, Antoine Italiano.
Nat Cancer, 2022 Feb 05; 2(8). PMID: 35118423    Free PMC article.
[Advances in the Study of Tumor-associated Macrophages in Lung Cancer].
Yanyan Qiao, Enqing Fu.
Zhongguo Fei Ai Za Zhi, 2022 Jan 26; 25(1). PMID: 35078283    Free PMC article.
PD-L1 CAR effector cells induce self-amplifying cytotoxic effects against target cells.
Malgorzata Bajor, Agnieszka Graczyk-Jarzynka, +14 authors, Radoslaw Zagozdzon.
J Immunother Cancer, 2022 Jan 27; 10(1). PMID: 35078921    Free PMC article.
Exosome-mediated genetic reprogramming of tumor-associated macrophages by exoASO-STAT6 leads to potent monotherapy antitumor activity.
Sushrut Kamerkar, Charan Leng, +15 authors, Sriram Sathyanarayanan.
Sci Adv, 2022 Feb 19; 8(7). PMID: 35179953    Free PMC article.
T Cells and CDDO-Me Attenuate Immunosuppressive Activation of Human Melanoma-Conditioned Macrophages.
Gretel M Torres, Heetaek Yang, +5 authors, Patricia A Pioli.
Front Immunol, 2022 Mar 11; 13. PMID: 35265066    Free PMC article.
Activating a collaborative innate-adaptive immune response to control metastasis.
Lijuan Sun, Tim Kees, +9 authors, Mikala Egeblad.
Cancer Cell, 2021 Sep 04; 39(10). PMID: 34478639    Free PMC article.
ONP-302 Nanoparticles Inhibit Tumor Growth By Altering Tumor-Associated Macrophages And Cancer-Associated Fibroblasts.
Laxminarasimha Donthireddy, Prashanthi Vonteddu, +11 authors, Dmitry I Gabrilovich.
J Cancer, 2022 Apr 12; 13(6). PMID: 35399717    Free PMC article.
CAR T cell therapy and the tumor microenvironment: Current challenges and opportunities.
Lionel A Kankeu Fonkoua, Olivia Sirpilla, +2 authors, Saad S Kenderian.
Mol Ther Oncolytics, 2022 Apr 19; 25. PMID: 35434273    Free PMC article.
Lipid-loaded tumor-associated macrophages sustain tumor growth and invasiveness in prostate cancer.
Michela Masetti, Roberta Carriero, +26 authors, Diletta Di Mitri.
J Exp Med, 2021 Dec 18; 219(2). PMID: 34919143    Free PMC article.
Myeloid cell-targeted therapies for solid tumours.
Sangeeta Goswami, Swetha Anandhan, Deblina Raychaudhuri, Padmanee Sharma.
Nat Rev Immunol, 2022 Jun 14;. PMID: 35697799