Journal Article
. 2018 May;4().
doi: 10.1038/s41394-018-0079-2.

Spinal cord injured women's treatment of breast carcinoma: alert to complications

Ashley L de Padua 1 Kimberly Strickland 2 Mary Patrick 3 John F Ditunno 1 
Affiliations
  • PMID: 29844929
  •     20 References

Abstract

Introduction: Women with spinal cord injury (SCI) and who develop breast cancer are a vulnerable and potentially overlooked population. They experience risk factors owing to decreased mobility and are at risk for unique complications from their oncologic treatment.

Case Presentation: A 54-year-old woman who suffered a T6 AIS A traumatic SCI in 1981, who was diagnosed 32 years later with estrogen receptor and progesterone receptor positive and human epidermal growth factor receptor 2-negative invasive ductal carcinoma. During the course of her chemotherapy, she experienced several complications, including reflexive diaphoresis, urinary tract infection, leukopenia, anemia, dehydration, and weakness. These contributed to the development of a stage 4 ischial pressure sore, which required complex treatment.

Discussion: There is a paucity of literature examining the complications of chemotherapy that may be unique to those with SCI. Physiatrists will be seeing more women undergoing oncologic care, as this population of patients ages. A multidisciplinary approach that takes into account the pathophysiologic changes associated with SCI is crucial to understand and prevent complications that could affect their outcomes and contribute to increased cost in a value-based health-care system.

Reflex sweating in patients with spinal cord injury: a review.
A Fast.
Arch Phys Med Rehabil, 1977 Oct 01; 58(10). PMID: 334108
Review.
Implications of mobility impairment on the diagnosis and treatment of breast cancer.
Lisa I Iezzoni, Elyse R Park, Kerry L Kilbridge.
J Womens Health (Larchmt), 2010 Nov 03; 20(1). PMID: 21034276    Free PMC article.
Characteristics of recurrent pressure ulcers in veterans with spinal cord injury.
Barbara M Bates-Jensen, Marylou Guihan, +2 authors, Stephen P Burns.
J Spinal Cord Med, 2009 Mar 07; 32(1). PMID: 19264047    Free PMC article.
Breast and cervical cancer screening among women with physical disabilities.
M A Nosek, C A Howland.
Arch Phys Med Rehabil, 1998 Jan 09; 78(12 Suppl 5). PMID: 9422006
Comprehensive management of pressure ulcers in spinal cord injury: current concepts and future trends.
Erwin A Kruger, Marilyn Pires, +2 authors, Salah Rubayi.
J Spinal Cord Med, 2013 Oct 05; 36(6). PMID: 24090179    Free PMC article.
Review.
Plasma catecholamines, plasma renin activity and plasma aldosterone in tetraplegic man, horizontal and tilted.
C J Mathias, N J Christensen, +3 authors, W S Peart.
Clin Sci Mol Med, 1975 Oct 01; 49(4). PMID: 1192688
Major risk factors for pressure ulcers in the spinal cord disabled: a literature review.
D W Byrne, C A Salzberg.
Spinal Cord, 1996 May 01; 34(5). PMID: 8963971
Review.
Glucose intolerance due to insulin resistance in patients with spinal cord injuries.
W C Duckworth, S S Solomon, +3 authors, A Powers.
Diabetes, 1980 Nov 01; 29(11). PMID: 7429029
Physiological changes in tissues denervated by spinal cord injury tissues and possible effects on wound healing.
Laurie M Rappl.
Int Wound J, 2008 Jan 22; 5(3). PMID: 18205787
Review.
A PIECE OF MY MIND. It's Rough Out There for Us.
Michael D Stillman, Steve R Williams.
JAMA, 2016 Aug 18; 316(6). PMID: 27532911
Incidence and clinical features of autonomic dysreflexia in patients with spinal cord injury.
R Lindan, E Joiner, A A Freehafer, C Hazel.
Paraplegia, 1980 Oct 01; 18(5). PMID: 7443280
A house of cards: women, aging and spinal cord injury.
M A McColl.
Spinal Cord, 2002 Jul 19; 40(8). PMID: 12124663
Cervical and breast cancer screening in wheelchair dependent females.
A Graham, G Savic, B Gardner.
Spinal Cord, 1998 May 28; 36(5). PMID: 9601114
Factors affecting wound healing.
S Guo, L A Dipietro.
J Dent Res, 2010 Feb 09; 89(3). PMID: 20139336    Free PMC article.
Highly Cited. Review.
Gene expression and benefit of chemotherapy in women with node-negative, estrogen receptor-positive breast cancer.
Soonmyung Paik, Gong Tang, +11 authors, Norman Wolmark.
J Clin Oncol, 2006 May 25; 24(23). PMID: 16720680
Highly Cited.
A multigene assay to predict recurrence of tamoxifen-treated, node-negative breast cancer.
Soonmyung Paik, Steven Shak, +12 authors, Norman Wolmark.
N Engl J Med, 2004 Dec 14; 351(27). PMID: 15591335
Highly Cited.
Patterns of recurrent pressure ulcers after spinal cord injury: identification of risk and protective factors 5 or more years after onset.
James S Krause, Lynne Broderick.
Arch Phys Med Rehabil, 2004 Aug 06; 85(8). PMID: 15295750
Pressure ulcers in intensive care patients: a review of risks and prevention.
B Paul J A Keller, Jan Wille, Bert van Ramshorst, Christian van der Werken.
Intensive Care Med, 2002 Oct 10; 28(10). PMID: 12373461
Review.
A systematic review of therapeutic interventions for pressure ulcers after spinal cord injury.
Mary Ann Regan, Robert W Teasell, +4 authors, Spinal Cord Injury Rehabilitation Evidence Research Team.
Arch Phys Med Rehabil, 2009 Feb 25; 90(2). PMID: 19236976    Free PMC article.
Systematic Review.
Prognostic and predictive value of the 21-gene recurrence score assay in postmenopausal women with node-positive, oestrogen-receptor-positive breast cancer on chemotherapy: a retrospective analysis of a randomised trial.
Kathy S Albain, William E Barlow, +20 authors, Breast Cancer Intergroup of North America.
Lancet Oncol, 2009 Dec 17; 11(1). PMID: 20005174    Free PMC article.
Highly Cited.