Journal Article
. 2018 Jun;379(2).
doi: 10.1056/NEJMoa1804710.

Adjuvant Chemotherapy Guided by a 21-Gene Expression Assay in Breast Cancer

Joseph A Sparano 1 Robert J Gray 1 Della F Makower 1 Kathleen I Pritchard 1 Kathy S Albain 1 Daniel F Hayes 1 Charles E Geyer 1 Elizabeth C Dees 1 Matthew P Goetz 1 John A Olson 1 Tracy Lively 1 Sunil S Badve 1 Thomas J Saphner 1 Lynne I Wagner 1 Timothy J Whelan 1 Matthew J Ellis 1 Soonmyung Paik 1 William C Wood 1 Peter M Ravdin 1 Maccon M Keane 1 Henry L Gomez Moreno 1 Pavan S Reddy 1 Timothy F Goggins 1 Ingrid A Mayer 1 Adam M Brufsky 1 Deborah L Toppmeyer 1 Virginia G Kaklamani 1 Jeffrey L Berenberg 1 Jeffrey Abrams 1 George W Sledge 1 
Affiliations
  • PMID: 29860917
  •     33 References
  •     304 citations

Abstract

Background: The recurrence score based on the 21-gene breast cancer assay predicts chemotherapy benefit if it is high and a low risk of recurrence in the absence of chemotherapy if it is low; however, there is uncertainty about the benefit of chemotherapy for most patients, who have a midrange score.

Methods: We performed a prospective trial involving 10,273 women with hormone-receptor-positive, human epidermal growth factor receptor 2 (HER2)-negative, axillary node-negative breast cancer. Of the 9719 eligible patients with follow-up information, 6711 (69%) had a midrange recurrence score of 11 to 25 and were randomly assigned to receive either chemoendocrine therapy or endocrine therapy alone. The trial was designed to show noninferiority of endocrine therapy alone for invasive disease-free survival (defined as freedom from invasive disease recurrence, second primary cancer, or death).

Results: Endocrine therapy was noninferior to chemoendocrine therapy in the analysis of invasive disease-free survival (hazard ratio for invasive disease recurrence, second primary cancer, or death [endocrine vs. chemoendocrine therapy], 1.08; 95% confidence interval, 0.94 to 1.24; P=0.26). At 9 years, the two treatment groups had similar rates of invasive disease-free survival (83.3% in the endocrine-therapy group and 84.3% in the chemoendocrine-therapy group), freedom from disease recurrence at a distant site (94.5% and 95.0%) or at a distant or local-regional site (92.2% and 92.9%), and overall survival (93.9% and 93.8%). The chemotherapy benefit for invasive disease-free survival varied with the combination of recurrence score and age (P=0.004), with some benefit of chemotherapy found in women 50 years of age or younger with a recurrence score of 16 to 25.

Conclusions: Adjuvant endocrine therapy and chemoendocrine therapy had similar efficacy in women with hormone-receptor-positive, HER2-negative, axillary node-negative breast cancer who had a midrange 21-gene recurrence score, although some benefit of chemotherapy was found in some women 50 years of age or younger. (Funded by the National Cancer Institute and others; TAILORx ClinicalTrials.gov number, NCT00310180 .).

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MAGI1, a New Potential Tumor Suppressor Gene in Estrogen Receptor Positive Breast Cancer.
Begoña Alday-Parejo, François Richard, +5 authors, Curzio Rüegg.
Cancers (Basel), 2020 Jan 23; 12(1). PMID: 31963297    Free PMC article.
The prognostic relevance of urokinase-type plasminogen activator (uPA) in the blood of patients with metastatic breast cancer.
Malgorzata Banys-Paluchowski, Isabell Witzel, +11 authors, Volkmar Müller.
Sci Rep, 2019 Feb 21; 9(1). PMID: 30783124    Free PMC article.
Overall survival is improved when DCIS accompanies invasive breast cancer.
Adam J Kole, Henry S Park, +3 authors, Abhijit A Patel.
Sci Rep, 2019 Jul 11; 9(1). PMID: 31289308    Free PMC article.
Prospective Validation of an Ex Vivo, Patient-Derived 3D Spheroid Model for Response Predictions in Newly Diagnosed Ovarian Cancer.
Stephen Shuford, Christine Wilhelm, +22 authors, Teresa M DesRochers.
Sci Rep, 2019 Aug 03; 9(1). PMID: 31371750    Free PMC article.
Cross comparison and prognostic assessment of breast cancer multigene signatures in a large population-based contemporary clinical series.
Johan Vallon-Christersson, Jari Häkkinen, +12 authors, Johan Staaf.
Sci Rep, 2019 Aug 23; 9(1). PMID: 31434940    Free PMC article.
21-Gene Recurrence Score and Adjuvant Chemotherapy Decision for Breast Cancer Patients with Positive Lymph Nodes.
Yiwei Tong, Jiayi Wu, +6 authors, Kunwei Shen.
Sci Rep, 2019 Sep 13; 9(1). PMID: 31511599    Free PMC article.
Clinical implications of drug-screening assay for recurrent metastatic hormone receptor-positive, human epidermal receptor 2-negative breast cancer using conditionally reprogrammed cells.
Rei Mimoto, Satomi Yogosawa, +5 authors, Hiroshi Takeyama.
Sci Rep, 2019 Sep 19; 9(1). PMID: 31527634    Free PMC article.
Impact of Genomic Assay Testing and Clinical Factors on Chemotherapy Use After Implementation of Standardized Testing Criteria.
Kelsey H Natsuhara, Katya Losk, +7 authors, Rachel A Freedman.
Oncologist, 2018 Aug 05; 24(5). PMID: 30076279    Free PMC article.
Can Less Be More for Individuals With Low-Risk Breast Cancer?
Kathy J Helzlsouer.
J Natl Cancer Inst, 2018 Sep 22; 110(12). PMID: 30239849    Free PMC article.
Online accounts of gene expression profiling in early-stage breast cancer: Interpreting genomic testing for chemotherapy decision making.
Emily Ross, Julia Swallow, Anne Kerr, Sarah Cunningham-Burley.
Health Expect, 2018 Nov 06; 22(1). PMID: 30387238    Free PMC article.
Community clinical practice patterns and mortality in patients with intermediate oncotype DX recurrence scores: Who benefits from chemotherapy?
Abiola F Ibraheem, David J Press, Olufunmilayo I Olopade, Dezheng Huo.
Cancer, 2018 Nov 06; 125(2). PMID: 30387876    Free PMC article.
Lymph node involvement: Positive about the role of the recurrence score in estrogen-driven breast cancer?
Kevin Kalinsky, Ruth M O'Regan.
Cancer, 2018 Nov 06; 125(2). PMID: 30387877    Free PMC article.
Breast Cancers With Magee Equation Score of Less Than 18, or 18-25 and Mitosis Score of 1, Do Not Require Oncotype DX Testing: A Value Study.
Rohit Bhargava, Beth Z Clark, David J Dabbs.
Am J Clin Pathol, 2018 Nov 06; 151(3). PMID: 30395177    Free PMC article.
PIWI-interacting RNA-36712 restrains breast cancer progression and chemoresistance by interaction with SEPW1 pseudogene SEPW1P RNA.
Liping Tan, Dongmei Mai, +17 authors, Dongxin Lin.
Mol Cancer, 2019 Jan 15; 18(1). PMID: 30636640    Free PMC article.
Highly Cited.
Evaluation of the Incidence of Hematologic Malignant Neoplasms Among Breast Cancer Survivors in France.
Marie Joelle Jabagi, Norbert Vey, +3 authors, Rosemary Dray-Spira.
JAMA Netw Open, 2019 Jan 19; 2(1). PMID: 30657534    Free PMC article.
Insights into Molecular Classifications of Triple-Negative Breast Cancer: Improving Patient Selection for Treatment.
Ana C Garrido-Castro, Nancy U Lin, Kornelia Polyak.
Cancer Discov, 2019 Jan 27; 9(2). PMID: 30679171    Free PMC article.
Highly Cited. Review.
Molecular and epigenetic profiles of BRCA1-like hormone-receptor-positive breast tumors identified with development and application of a copy-number-based classifier.
Youdinghuan Chen, Yue Wang, +6 authors, Brock C Christensen.
Breast Cancer Res, 2019 Jan 27; 21(1). PMID: 30683142    Free PMC article.
Neoadjuvant Management of Early Breast Cancer: A Clinical and Investigational Position Statement.
Ramon Colomer, Cristina Saura, +7 authors, Ana Lluch.
Oncologist, 2019 Feb 03; 24(5). PMID: 30710068    Free PMC article.
A Phase II Randomized Study of Neoadjuvant Letrozole Plus Alpelisib for Hormone Receptor-Positive, Human Epidermal Growth Factor Receptor 2-Negative Breast Cancer (NEO-ORB).
Ingrid A Mayer, Aleix Prat, +20 authors, Carlos L Arteaga.
Clin Cancer Res, 2019 Feb 07; 25(10). PMID: 30723140    Free PMC article.
Tailored NEOadjuvant epirubicin, cyclophosphamide and Nanoparticle Albumin-Bound paclitaxel for breast cancer: The phase II NEONAB trial-Clinical outcomes and molecular determinants of response.
Caitlin Murphy, Andrea Muscat, +10 authors, Mustafa Khasraw.
PLoS One, 2019 Feb 15; 14(2). PMID: 30763338    Free PMC article.
SHON expression predicts response and relapse risk of breast cancer patients after anthracycline-based combination chemotherapy or tamoxifen treatment.
Tarek M A Abdel-Fatah, Reuben J Broom, +20 authors, Dong-Xu Liu.
Br J Cancer, 2019 Mar 01; 120(7). PMID: 30816325    Free PMC article.
Clinical validation of an immunohistochemistry-based CanAssist-Breast test for distant recurrence prediction in hormone receptor-positive breast cancer patients.
Manjiri M Bakre, Charusheila Ramkumar, +10 authors, Mark D Pegram.
Cancer Med, 2019 Mar 09; 8(4). PMID: 30848103    Free PMC article.
A clinical decision support system learned from data to personalize treatment recommendations towards preventing breast cancer metastasis.
Xia Jiang, Alan Wells, Adam Brufsky, Richard Neapolitan.
PLoS One, 2019 Mar 09; 14(3). PMID: 30849111    Free PMC article.
A blood-based prognostic biomarker in IBD.
Daniele Biasci, James C Lee, +9 authors, Kenneth G C Smith.
Gut, 2019 Apr 29; 68(8). PMID: 31030191    Free PMC article.
Oncotype DX for Comprehensive Treatment in Male Breast Cancer: A Case Report and Literature Review.
Ang Zheng, Lin Zhang, +2 authors, Feng Jin.
Am J Mens Health, 2019 May 10; 13(3). PMID: 31068065    Free PMC article.
Review.
Avoiding over- and undertreatment in patients with resected node-positive breast cancer with the use of gene expression signatures: are we there yet?
A Matikas, T Foukakis, S Swain, J Bergh.
Ann Oncol, 2019 May 28; 30(7). PMID: 31131397    Free PMC article.
Review.
A simple immunohistochemical bio-profile incorporating Bcl2 curbs those cases of invasive breast carcinoma for which an Oncotype Dx characterization is needed.
Claudio Ceccarelli, Antonio De Leo, +5 authors, Donatella Santini.
PLoS One, 2019 Jun 04; 14(6). PMID: 31158261    Free PMC article.
Utility of a ready-to-use PCR system for neuroendocrine tumor diagnosis.
Mark Kidd, Ignat A Drozdov, +6 authors, Irvin M Modlin.
PLoS One, 2019 Jun 28; 14(6). PMID: 31247038    Free PMC article.
Oncotype DX: Where Does It Stand in India?
Atul Batra, Amol Patel, +6 authors, Priyanka Srivastava.
J Glob Oncol, 2019 Jul 17; 5. PMID: 31310569    Free PMC article.
From the Broad Phase II Trial to Precision Oncology: A Perspective on the Origins of Basket and Umbrella Clinical Trial Designs in Cancer Drug Development.
Deborah B Doroshow, James H Doroshow.
Cancer J, 2019 Jul 25; 25(4). PMID: 31335388    Free PMC article.
A Multigene Assay Determines Risk of Recurrence in Patients with Triple-Negative Breast Cancer.
Rachel L Stewart, Katherine L Updike, +4 authors, Katherine E Varley.
Cancer Res, 2019 May 03; 79(13). PMID: 31048497    Free PMC article.
Association of Germline Genetic Testing Results With Locoregional and Systemic Therapy in Patients With Breast Cancer.
Allison W Kurian, Kevin C Ward, +5 authors, Steven J Katz.
JAMA Oncol, 2020 Feb 07; 6(4). PMID: 32027353    Free PMC article.
Considering adjuvant therapy for stage II melanoma.
Andrew S Poklepovic, Jason J Luke.
Cancer, 2019 Dec 24; 126(6). PMID: 31869447    Free PMC article.
Review.
Re: Expected Monetary Impact of Oncotype DX Score-Concordant Systemic Breast Cancer Therapy Based on the TAILORx Trial.
Paolo Giorgi Rossi, Eugenio Paci.
J Natl Cancer Inst, 2019 Jun 20; 112(3). PMID: 31214709    Free PMC article.
The Utility of Oncotype DX for Adjuvant Chemotherapy Treatment Decisions in Estrogen Receptor-positive, Human Epidermal Growth Factor Receptor 2-negative, Node-negative Breast Cancer.
Hirah Rizki, Christopher Hillyar, Omar Abbassi, Sascha Miles-Dua.
Cureus, 2020 Mar 21; 12(3). PMID: 32195072    Free PMC article.
Association of Diabetes and Other Clinical and Sociodemographic Factors With Guideline-concordant Breast Cancer Treatment for Breast Cancer.
Heather T Gold, Huibo Shao, +4 authors, Denise Boudreau.
Am J Clin Oncol, 2019 Dec 19; 43(2). PMID: 31850918    Free PMC article.
A new clinical-genomic model to predict 10-year recurrence risk in primary operable breast cancer patients.
Tzu-Ting Huang, Lei Lei, +3 authors, Skye Hung-Chun Cheng.
Sci Rep, 2020 Mar 19; 10(1). PMID: 32184406    Free PMC article.
Decision-making of Adjuvant Chemotherapy for Breast Cancer Patients with Discordant Risk Classifications between Clinical-Pathological Factors and 21-gene Recurrence Score.
Weiqi Gao, Lin Lin, +2 authors, Kunwei Shen.
J Cancer, 2020 Mar 24; 11(9). PMID: 32201521    Free PMC article.
A Radiation Oncologist's Guide to Axillary Management in Breast Cancer: A Walk Through the Trials.
Julie K Jang, Elana R Sverdlik, Naomi R Schechter.
Curr Breast Cancer Rep, 2020 Mar 28; 11(4). PMID: 32215182    Free PMC article.
The impact of Oncotype DX breast cancer assay results on clinical practice: a UK experience.
Valerie E Crolley, Husam Marashi, +12 authors, Judy King.
Breast Cancer Res Treat, 2020 Mar 15; 180(3). PMID: 32170635    Free PMC article.
Xenograft-based, platform-independent gene signatures to predict response to alkylating chemotherapy, radiation, and combination therapy for glioblastoma.
Shuang G Zhao, Menggang Yu, +9 authors, Daniel R Wahl.
Neuro Oncol, 2019 May 24; 21(9). PMID: 31121035    Free PMC article.
Cytoplasmic Cyclin E Is an Independent Marker of Aggressive Tumor Biology and Breast Cancer-Specific Mortality in Women over 70 Years of Age.
Simon J Johnston, Binafsha M Syed, +8 authors, Kwok-Leung Cheung.
Cancers (Basel), 2020 Mar 22; 12(3). PMID: 32197318    Free PMC article.
Gene Expression Profiling Tests for Early-Stage Invasive Breast Cancer: A Health Technology Assessment.
Ontario Health (Quality).
Ont Health Technol Assess Ser, 2020 Apr 15; 20(10). PMID: 32284770    Free PMC article.
The Correlation of Magee EquationsTM and Oncotype DX® Recurrence Score From Core Needle Biopsy Tissues in Predicting Response to Neoadjuvant Chemotherapy in ER+ and HER2- Breast Cancer.
Atilla Soran, Kaori Tane, Efe Sezgin, Rohit Bhargava.
Eur J Breast Health, 2020 Apr 15; 16(2). PMID: 32285033    Free PMC article.
Identification of risk in cutaneous melanoma patients: Prognostic and predictive markers.
David M Hyams, Robert W Cook, Antonio C Buzaid.
J Surg Oncol, 2018 Dec 15; 119(2). PMID: 30548543    Free PMC article.
Review.
Risk stratification of ER-positive breast cancer patients: A multi-institutional validation and outcome study of the Rochester Modified Magee algorithm (RoMMa) and prediction of an Oncotype DX® recurrence score <26.
Bradley M Turner, Mary Ann Gimenez-Sanders, +6 authors, David G Hicks.
Cancer Med, 2019 Jun 15; 8(9). PMID: 31199586    Free PMC article.
Breast Cancer: A Molecularly Heterogenous Disease Needing Subtype-Specific Treatments.
Ugo Testa, Germana Castelli, Elvira Pelosi.
Med Sci (Basel), 2020 Mar 27; 8(1). PMID: 32210163    Free PMC article.
Review.
Absolute Improvements in Freedom From Distant Recurrence to Tailor Adjuvant Endocrine Therapies for Premenopausal Women: Results From TEXT and SOFT.
Olivia Pagani, Prudence A Francis, +13 authors, SOFT and TEXT Investigators and International Breast Cancer Study Group.
J Clin Oncol, 2019 Oct 17; 38(12). PMID: 31618131    Free PMC article.
Serum bone markers and risk of osteoporosis and fragility fractures in women who received endocrine therapy for breast cancer: a prospective study.
Song Yao, Cecile A Laurent, +6 authors, Marilyn L Kwan.
Breast Cancer Res Treat, 2020 Jan 09; 180(1). PMID: 31912328    Free PMC article.
Ki-67 index, progesterone receptor expression, histologic grade and tumor size in predicting breast cancer recurrence risk: A consecutive cohort study.
Yanna Zhang, Yidong Zhou, +2 authors, Qiang Sun.
Cancer Commun (Lond), 2020 Apr 16; 40(4). PMID: 32291973    Free PMC article.
Aim for Clinical Utility, Not Just Predictive Accuracy.
Michael C Sachs, Arvid Sjölander, Erin E Gabriel.
Epidemiology, 2020 Feb 25; 31(3). PMID: 32091429    Free PMC article.
Update Breast Cancer 2020 Part 2 - Advanced Breast Cancer: New Treatments and Implementation of Therapies with Companion Diagnostics.
Diana Lüftner, Andreas Schneeweiss, +16 authors, Michael P Lux.
Geburtshilfe Frauenheilkd, 2020 Apr 24; 80(4). PMID: 32322108    Free PMC article.
Double Trouble: Contralateral Breast Cancer Risk Management in the Modern Era.
Kevin J Cheung, Nancy E Davidson.
J Natl Cancer Inst, 2019 Jan 31; 111(7). PMID: 30698728    Free PMC article.
Recommendations for prioritization, treatment, and triage of breast cancer patients during the COVID-19 pandemic. the COVID-19 pandemic breast cancer consortium.
Jill R Dietz, Meena S Moran, +16 authors, Katharine A Yao.
Breast Cancer Res Treat, 2020 Apr 26; 181(3). PMID: 32333293    Free PMC article.
Highly Cited.
Simulation Modeling to Extend Clinical Trials of Adjuvant Chemotherapy Guided by a 21-Gene Expression Assay in Early Breast Cancer.
Jinani Jayasekera, Joseph A Sparano, +5 authors, Jeanne Mandelblatt.
JNCI Cancer Spectr, 2020 Apr 28; 3(4). PMID: 32337487    Free PMC article.
Programmed death-ligand 1 gene expression is a prognostic marker in early breast cancer and provides additional prognostic value to 21-gene and 70-gene signatures in estrogen receptor-positive disease.
Ioannis Zerdes, Emmanouil G Sifakis, +6 authors, Theodoros Foukakis.
Mol Oncol, 2020 Mar 03; 14(5). PMID: 32115850    Free PMC article.
Race and risk of subsequent aggressive breast cancer following ductal carcinoma in situ.
Ying Liu, Robert West, Jason D Weber, Graham A Colditz.
Cancer, 2019 May 24; 125(18). PMID: 31120565    Free PMC article.
Correlation Between Oncotype DX, PREDICT and the Nottingham Prognostic Index: Implications for the Management of Early Breast Cancer.
Christopher Hillyar, Hirah Rizki, +4 authors, Simon Smith.
Cureus, 2020 May 10; 12(4). PMID: 32382456    Free PMC article.
Chromatin regulators mediate anthracycline sensitivity in breast cancer.
Jose A Seoane, Jacob G Kirkland, +2 authors, Christina Curtis.
Nat Med, 2019 Nov 09; 25(11). PMID: 31700186    Free PMC article.
Maximizing Breast Cancer Therapy with Awareness of Potential Treatment-Related Blood Disorders.
Henry G Kaplan, Gregory S Calip, Judith A Malmgren.
Oncologist, 2020 Feb 20; 25(5). PMID: 32073195    Free PMC article.
Review.
Breast cancer diagnosis based on lipid profiling by probe electrospray ionization mass spectrometry.
T Iwano, K Yoshimura, +7 authors, S Takeda.
Br J Surg, 2020 Apr 05; 107(6). PMID: 32246473    Free PMC article.
Breast Cancer Statistics in Korea in 2017: Data from a Breast Cancer Registry.
Sang Yull Kang, Yoo Seok Kim, +11 authors, Korean Breast Cancer Society.
J Breast Cancer, 2020 May 13; 23(2). PMID: 32395372    Free PMC article.
Review.
Commercially Available Gene Expression Assays as Predictive Tools for Adjuvant Radiotherapy? A Critical Review.
David Krug, René Baumann, +12 authors, Rolf Sauer.
Breast Care (Basel), 2020 May 14; 15(2). PMID: 32398980    Free PMC article.
Review.
Model Combining Tumor Molecular and Clinicopathologic Risk Factors Predicts Sentinel Lymph Node Metastasis in Primary Cutaneous Melanoma.
Domenico Bellomo, Suzette M Arias-Mejias, +18 authors, Alexander Meves.
JCO Precis Oncol, 2020 May 15; 4. PMID: 32405608    Free PMC article.
Personalized circulating tumor DNA analysis to detect residual disease after neoadjuvant therapy in breast cancer.
Bradon R McDonald, Tania Contente-Cuomo, +17 authors, Muhammed Murtaza.
Sci Transl Med, 2019 Aug 09; 11(504). PMID: 31391323    Free PMC article.
Talking the Talk About Tumor Genomic Testing.
Richard L Schilsky.
J Natl Cancer Inst, 2019 Nov 02; 112(5). PMID: 31675090    Free PMC article.
G2M Cell Cycle Pathway Score as a Prognostic Biomarker of Metastasis in Estrogen Receptor (ER)-Positive Breast Cancer.
Masanori Oshi, Hideo Takahashi, +5 authors, Kazuaki Takabe.
Int J Mol Sci, 2020 Apr 26; 21(8). PMID: 32331421    Free PMC article.
21-Gene Recurrence Score Adds Significant Value for Grade 3 Breast Cancers: Results From a National Cohort.
J Bryan Iorgulescu, Rachel A Freedman, +2 authors, Jane E Brock.
JCO Precis Oncol, 2019 Jan 01; 3. PMID: 32457931    Free PMC article.
Strategies to Improve Recruitment to a De-escalation Trial: A Mixed-Methods Study of the OPTIMA Prelim Trial in Early Breast Cancer.
C Conefrey, J L Donovan, +18 authors, OPTIMA Prelim Study Group.
Clin Oncol (R Coll Radiol), 2020 Feb 25; 32(6). PMID: 32089356    Free PMC article.
Low Overall Survival in Women With De Novo Metastatic Breast Cancer: Does This Reflect Tumor Biology or a Lack of Access to Health Care?
Leonardo R Soares, Ruffo Freitas-Junior, +3 authors, José C Oliveira.
JCO Glob Oncol, 2020 Apr 30; 6. PMID: 32348160    Free PMC article.
Do 21-Gene Recurrence Score Influence Chemotherapy Decisions in T1bN0 Breast Cancer Patients?
Jing Yu, Jiayi Wu, +6 authors, Kunwei Shen.
Front Oncol, 2020 Jun 02; 10. PMID: 32477946    Free PMC article.
Review of precision cancer medicine: Evolution of the treatment paradigm.
Apostolia M Tsimberidou, Elena Fountzilas, Mina Nikanjam, Razelle Kurzrock.
Cancer Treat Rev, 2020 Apr 07; 86. PMID: 32251926    Free PMC article.
Review.
Impact of Recurrence Score on type and duration of chemotherapy in breast cancer.
K Willemsma, W Yip, +5 authors, C E Simmons.
Curr Oncol, 2020 Jun 04; 27(2). PMID: 32489257    Free PMC article.
Characterization of Hypoxia Signature to Evaluate the Tumor Immune Microenvironment and Predict Prognosis in Glioma Groups.
Wanzun Lin, Shihong Wu, +7 authors, Sufang Qiu.
Front Oncol, 2020 Jun 06; 10. PMID: 32500034    Free PMC article.
Efficacy of neoadjuvant endocrine therapy compared with neoadjuvant chemotherapy in pre-menopausal patients with oestrogen receptor-positive and HER2-negative, lymph node-positive breast cancer.
Hee Jeong Kim, Woo Chul Noh, +7 authors, Sei Hyun Ahn.
Breast Cancer Res, 2020 May 29; 22(1). PMID: 32460816    Free PMC article.
Risk factors of distant metastasis after surgery among different breast cancer subtypes: a hospital-based study in Indonesia.
Sumadi Lukman Anwar, Widya Surya Avanti, +5 authors, Wahyu Wulaningsih.
World J Surg Oncol, 2020 Jun 01; 18(1). PMID: 32473643    Free PMC article.
Prognostic impact of ACTN4 gene copy number alteration in hormone receptor-positive, HER2-negative, node-negative invasive breast carcinoma.
Teppei Sugano, Masayuki Yoshida, +7 authors, Tesshi Yamada.
Br J Cancer, 2020 Apr 09; 122(12). PMID: 32265507    Free PMC article.
Patients' perceptions of 70-gene signature testing: commonly changing the initial inclination to undergo or forego chemotherapy and reducing decisional conflict.
Julia E C van Steenhoven, Bianca M den Dekker, +6 authors, Thijs van Dalen.
Breast Cancer Res Treat, 2020 May 21; 182(1). PMID: 32430679    Free PMC article.
EndoPredict® in early hormone receptor-positive, HER2-negative breast cancer.
K Almstedt, S Mendoza, +9 authors, M Schmidt.
Breast Cancer Res Treat, 2020 May 22; 182(1). PMID: 32436145    Free PMC article.
Unmet Clinical Need: Developing Prognostic Biomarkers and Precision Medicine to Forecast Early Tumor Relapse, Detect Chemo-Resistance and Improve Overall Survival in High-Risk Breast Cancer.
Gagan Gupta, Caroline Dasom Lee, +10 authors, Amy H Tang.
Ann Breast Cancer Ther, 2020 Jun 17; 4(1). PMID: 32542231    Free PMC article.
Cognitive Impairment in Patients With Breast Cancer: Understanding the Impact of Chemotherapy and Endocrine Therapy.
Patricia A Ganz, Kathleen Van Dyk.
J Clin Oncol, 2020 Mar 07; 38(17). PMID: 32142394    Free PMC article.
Patient-Reported Cognitive Impairment Among Women With Early Breast Cancer Randomly Assigned to Endocrine Therapy Alone Versus Chemoendocrine Therapy: Results From TAILORx.
Lynne I Wagner, Robert J Gray, +16 authors, David Cella.
J Clin Oncol, 2020 Apr 10; 38(17). PMID: 32271671    Free PMC article.
RDGN-based predictive model for the prognosis of breast cancer.
Bing Dong, Ming Yi, +2 authors, Kongming Wu.
Exp Hematol Oncol, 2020 Jun 19; 9. PMID: 32550045    Free PMC article.
Deep learning-based survival prediction for multiple cancer types using histopathology images.
Ellery Wulczyn, David F Steiner, +7 authors, Martin C Stumpe.
PLoS One, 2020 Jun 20; 15(6). PMID: 32555646    Free PMC article.
Distribution of the 21-Gene Breast Recurrence Score in Patients with Primary Breast Cancer in Germany.
Vincent P Walter, Florin-Andrei Taran, +6 authors, Andreas Daniel Hartkopf.
Geburtshilfe Frauenheilkd, 2020 Jun 23; 80(6). PMID: 32565552    Free PMC article.
Simulation of Chemotherapy Effects in Older Breast Cancer Patients With High Recurrence Scores.
Young Chandler, Jinani C Jayasekera, +3 authors, Jeanne S Mandelblatt.
J Natl Cancer Inst, 2019 Oct 16; 112(6). PMID: 31612208    Free PMC article.
Adjuvant Chemotherapy for Older Patients With Breast Cancer: When Is the Pain Worth the Gain?
Rachel A Freedman, Eric P Winer.
J Natl Cancer Inst, 2019 Oct 16; 112(6). PMID: 31612212    Free PMC article.
Impact of Oncotype DX Recurrence Score on the Patterns of Locoregional Recurrence in Breast Cancer (Korean Radiation Oncology Group 19-06).
Kyubo Kim, Jinhong Jung, +7 authors, Jee Suk Chang.
J Breast Cancer, 2020 Jul 01; 23(3). PMID: 32595993    Free PMC article.
Impact of chemotherapy, radiotherapy, and endocrine therapy on sick leave in women with early-stage breast cancer during a 5-year period: a population-based cohort study.
Anna Plym, Anna L V Johansson, +4 authors, Mats Lambe.
Breast Cancer Res Treat, 2020 Jun 09; 182(3). PMID: 32506337    Free PMC article.
Trends in utilization of sentinel node biopsy and adjuvant radiation in women ≥ 70.
Jinny Gunn, Riccardo Lemini, +6 authors, Emmanuel Gabriel.
Breast J, 2020 Jan 08; 26(7). PMID: 31908095    Free PMC article.
The concordance of treatment decision guided by OncotypeDX and the PREDICT tool in real-world early-stage breast cancer.
Daniel A Goldstein, Chen Mayer, +5 authors, Hadar Goldvaser.
Cancer Med, 2020 May 07; 9(13). PMID: 32372569    Free PMC article.
A Value of Information Analysis of Research on the 21-Gene Assay for Breast Cancer Management.
Natalia R Kunst, Fernando Alarid-Escudero, A David Paltiel, Shi-Yi Wang.
Value Health, 2019 Sep 30; 22(10). PMID: 31563252    Free PMC article.
Case 22-2020: A 62-Year-Old Woman with Early Breast Cancer during the Covid-19 Pandemic.
Laura M Spring, Michelle C Specht, +6 authors, Beverly Moy.
N Engl J Med, 2020 Jul 02; 383(3). PMID: 32610007    Free PMC article.
Current State of the Art in the Adjuvant Systemic Treatment of Premenopausal Patients With Early Breast Cancer.
Francesca Parisi, Maria Grazia Razeti, +7 authors, Matteo Lambertini.
Clin Med Insights Oncol, 2020 Jul 11; 14. PMID: 32647477    Free PMC article.
Sarcopenia and monocyte-to-lymphocyte ratio as prognostic factors in early-stage breast cancer.
Emma Zattarin, Claudio Vernieri.
Ann Transl Med, 2020 Jul 11; 8(12). PMID: 32647662    Free PMC article.
Features, Outcomes, and Management Strategies of Male Breast Cancer: A Single Institution Comparison to Well-Matched Female Controls.
Joseph Liu, Anupama Suresh, +18 authors, Robert Wesolowski.
Eur J Breast Health, 2020 Jul 14; 16(3). PMID: 32656521    Free PMC article.
Nodal positivity decreases with age in women with early-stage, hormone receptor-positive breast cancer.
Stephanie M Downs-Canner, Charles E Gaber, +4 authors, David W Ollila.
Cancer, 2019 Dec 21; 126(6). PMID: 31860136    Free PMC article.
Management of hormone receptor-positive, HER2-negative early breast cancer.
Elaine M Walsh, Karen L Smith, Vered Stearns.
Semin Oncol, 2020 Jun 18; 47(4). PMID: 32546323    Free PMC article.
Review.
Sex Disparity Observed for Oncotype DX Breast Recurrence Score in Predicting Mortality Among Patients with Early Stage ER-Positive Breast Cancer.
Fei Wang, Sonya Reid, +6 authors, Xiao-Ou Shu.
Clin Cancer Res, 2019 Nov 22; 26(1). PMID: 31748278    Free PMC article.
The Potential Use of Tumour-Based Prognostic and Predictive Tools in Older Women with Primary Breast Cancer: A Narrative Review.
Sophie Gordon-Craig, Ruth M Parks, Kwok-Leung Cheung.
Oncol Ther, 2020 Jul 24; 8(2). PMID: 32700048    Free PMC article.
Review.
Adjuvant chemotherapy for node negative, high Recurrence ScoreTM breast cancer: in defense of de-escalation.
Diana Lake, Andrew D Seidman.
NPJ Breast Cancer, 2019 Aug 21; 5. PMID: 31428677    Free PMC article.
Prognostic potential of automated Ki67 evaluation in breast cancer: different hot spot definitions versus true global score.
Stephanie Robertson, Balazs Acs, Michael Lippert, Johan Hartman.
Breast Cancer Res Treat, 2020 Jun 24; 183(1). PMID: 32572716    Free PMC article.
Decision of adjuvant chemotherapy in intermediate risk luminal breast cancer patients: A prospective multicenter trial assessing the clinical and psychological impact of EndoPredict® (EpClin) use (UCBG 2-14).
Frédérique Penault-Llorca, Fabrice Kwiatkowski, +18 authors, Suzette Delaloge.
Breast, 2019 Dec 04; 49. PMID: 31790959    Free PMC article.
Should women with early breast cancer under 40 years of age have a routine 21-gene recurrence score testing: A SEER database study.
Kai-Hua Liu, Lei Zhang, +4 authors, San-Gang Wu.
Breast, 2020 Jan 10; 49. PMID: 31918322    Free PMC article.
Do YOU know the Ki-67 index of your breast cancer patients? Knowledge of your institution's Ki-67 index distribution and its robustness is essential for decision-making in early breast cancer.
Angela Fischer Maranta, Simon Broder, +4 authors, Thomas Ruhstaller.
Breast, 2020 Apr 18; 51. PMID: 32302928    Free PMC article.
Prospective observational study on the impact of the 21-gene assay on treatment decisions and resources optimization in breast cancer patients in Lombardy: The BONDX study.
Alberto Zambelli, Edda Simoncini, +11 authors, Carlo Tondini.
Breast, 2020 Apr 24; 52. PMID: 32325372    Free PMC article.
A system for risk stratification and prioritization of breast cancer surgeries delayed by the COVID-19 pandemic: preparing for re-entry.
Barbara L Smith, Anvy Nguyen, +6 authors, Michele A Gadd.
Breast Cancer Res Treat, 2020 Jul 28; 183(3). PMID: 32712878    Free PMC article.
Review.
Clinicopathological characteristics, adjuvant chemotherapy decision and disease outcome in patients with breast cancer with a 21-gene recurrence score of 26-30.
Jing Yu, Jiayi Wu, +6 authors, Kunwei Shen.
Oncol Lett, 2020 Jul 30; 20(2). PMID: 32724396    Free PMC article.
AGO Recommendations for the Diagnosis and Treatment of Patients with Early Breast Cancer: Update 2019.
Nina Ditsch, Michael Untch, +42 authors, Achim Wöckel.
Breast Care (Basel), 2019 Sep 29; 14(4). PMID: 31558897    Free PMC article.
Review.
Overview of Breast Cancer and Implications of Overtreatment of Early-Stage Breast Cancer: An Indian Perspective.
Gouri Shankar Bhattacharyya, Dinesh C Doval, +3 authors, S P Somashekhar.
JCO Glob Oncol, 2020 Jun 09; 6. PMID: 32511068    Free PMC article.
The healthcare value of the Magee Decision Algorithm™: use of Magee Equations™ and mitosis score to safely forgo molecular testing in breast cancer.
Rohit Bhargava, Beth Z Clark, +2 authors, David J Dabbs.
Mod Pathol, 2020 Mar 24; 33(8). PMID: 32203092    Free PMC article.
Propensity score analysis of the prognostic value of genomic assays for breast cancer in diverse populations using the National Cancer Data Base.
Abiola Ibraheem, Olufunmilayo I Olopade, Dezheng Huo.
Cancer, 2020 Jun 11; 126(17). PMID: 32521056    Free PMC article.
The 21-Gene Recurrence Score Assay and Prediction of Chemotherapy Benefit: A Propensity Score-Matched Analysis of the SEER Database.
In Sil Choi, Jiwoong Jung, +5 authors, Ki-Tae Hwang.
Cancers (Basel), 2020 Jul 12; 12(7). PMID: 32650374    Free PMC article.
Personalised medicine and the decision to withhold chemotherapy in early breast cancer with intermediate risk of recurrence - a systematic review and meta-analysis.
Susanna M Wallerstedt, Astrid Nilsson Ek, +3 authors, Barbro Linderholm.
Eur J Clin Pharmacol, 2020 Jun 07; 76(9). PMID: 32504183    Free PMC article.
Review.
Discordance in 21-gene recurrence scores between paired breast cancer samples is inversely associated with patient age.
Sarah M Bernhardt, Pallave Dasari, +6 authors, Wendy V Ingman.
Breast Cancer Res, 2020 Aug 20; 22(1). PMID: 32811558    Free PMC article.
Prognostic significance of residual nodal disease after neoadjuvant endocrine therapy for hormone receptor-positive breast cancer.
Olga Kantor, Stephanie Wong, +3 authors, Tari A King.
NPJ Breast Cancer, 2020 Aug 22; 6. PMID: 32821803    Free PMC article.
Metabolomic analysis of serum may refine 21-gene expression assay risk recurrence stratification.
Amelia McCartney, Alessia Vignoli, +6 authors, Angelo Di Leo.
NPJ Breast Cancer, 2019 Sep 05; 5. PMID: 31482106    Free PMC article.
Primary 21-Gene Recurrence Score and Disease Outcome in Loco-Regional and Distant Recurrent Breast Cancer Patients.
Yujie Lu, Yiwei Tong, +10 authors, Kunwei Shen.
Front Oncol, 2020 Aug 28; 10. PMID: 32850415    Free PMC article.
Cases in Precision Medicine: The Role of Tumor and Germline Genetic Testing in Breast Cancer Management.
Jonah Tischler, Katherine D Crew, Wendy K Chung.
Ann Intern Med, 2019 Oct 22; 171(12). PMID: 31634909    Free PMC article.
Association of Endocrine Therapy With Overall Survival in Women With Small, Hormone Receptor-Positive, ERBB2-Negative Breast Cancer.
Sung Jun Ma, Oluwadamilola T Oladeru, Anurag K Singh.
JAMA Netw Open, 2020 Aug 25; 3(8). PMID: 32833014    Free PMC article.
Four cycles of docetaxel and cyclophosphamide as adjuvant chemotherapy in node negative breast cancer: A real-world study.
Atul Batra, Malek B Hannouf, Noura Alsafar, Sasha Lupichuk.
Breast, 2020 Aug 31; 54. PMID: 32861882    Free PMC article.
Computational approaches to support comparative analysis of multiparametric tests: Modelling versus Training.
John M S Bartlett, Jane Bayani, +8 authors, OPTIMA Trial Management Group.
PLoS One, 2020 Sep 04; 15(9). PMID: 32881987    Free PMC article.
Susan G. Komen Big Data for Breast Cancer Initiative: How Patient Advocacy Organizations Can Facilitate Using Big Data to Improve Patient Outcomes.
Jerome Jourquin, Stephanie Birkey Reffey, +5 authors, George Sledge.
JCO Precis Oncol, 2020 Sep 15; 3. PMID: 32923852    Free PMC article.
Biomarker-Driven Oncology Clinical Trials: Key Design Elements, Types, Features, and Practical Considerations.
Chen Hu, James J Dignam.
JCO Precis Oncol, 2020 Sep 15; 3. PMID: 32923854    Free PMC article.
Review.
Six versus 12 months' adjuvant trastuzumab in patients with HER2-positive early breast cancer: the PERSEPHONE non-inferiority RCT.
Helena Earl, Louise Hiller, +24 authors, Janet A Dunn.
Health Technol Assess, 2020 Sep 04; 24(40). PMID: 32880572    Free PMC article.
BCL-2 expression aids in the immunohistochemical prediction of the Oncotype DX breast cancer recurrence score.
Mark D Zarella, Rebecca C Heintzelman, Nikolay K Popnikolov, Fernando U Garcia.
BMC Clin Pathol, 2018 Dec 24; 18. PMID: 30574014    Free PMC article.
Development of an e-health app to support women prescribed adjuvant endocrine therapy after treatment for breast cancer.
Jo Brett, Mary Boulton, Eila Watson.
Patient Prefer Adherence, 2018 Dec 28; 12. PMID: 30587936    Free PMC article.
Simulation modeling approaches to answer clinically relevant questions in breast cancer low-risk populations.
Ana Calin, Miguel Martin, Sara Lopez-Tarruella.
Ann Transl Med, 2019 Jan 08; 6(Suppl 1). PMID: 30613655    Free PMC article.
The Distribution and Outcomes of the 21-Gene Recurrence Score in T1-T2N0 Estrogen Receptor-Positive Breast Cancer With Different Histologic Subtypes.
Jun Wang, Zhen-Yu He, +3 authors, San-Gang Wu.
Front Genet, 2019 Jan 09; 9. PMID: 30619463    Free PMC article.
Clinical validation of Ki67 by quantitative reverse transcription-polymerase chain reaction (RT-PCR) in HR+/HER2- early breast cancer.
Weiqi Gao, Jiayi Wu, +4 authors, Ou Huang.
J Cancer, 2019 Mar 12; 10(5). PMID: 30854118    Free PMC article.
Effect of 21-gene recurrence score in decision-making for surgery in early stage breast cancer.
San-Gang Wu, Wen-Wen Zhang, +3 authors, Zhen-Yu He.
Onco Targets Ther, 2019 Apr 10; 12. PMID: 30962690    Free PMC article.
Identification of Prognostic Alternative Splicing Signature in Breast Carcinoma.
Dong Zhang, Yi Duan, Jinjing Cun, Qifeng Yang.
Front Genet, 2019 Apr 16; 10. PMID: 30984247    Free PMC article.
A novel LARCassigner3 classification predicts outcomes in patients with locally advanced rectal cancer treated with neoadjuvant chemoradiotherapy: a retrospective training and validation analysis.
Jing Zhang, Lijun Shen, +10 authors, Zhen Zhang.
Cancer Manag Res, 2019 May 28; 11. PMID: 31123421    Free PMC article.
The Effect of the New Eighth Edition Breast Cancer Staging System on 100 Consecutive Patients.
Ashley Biswal, Jacqueline Erler, +6 authors, Denise Johnson Miller.
J Clin Med Res, 2019 May 31; 11(6). PMID: 31143307    Free PMC article.
Should a Multigene Signature be Used in all Luminal Early Breast Cancers.
Nawale Hajjaji, Yves Marie Robin, Jacques Bonneterre.
Front Oncol, 2019 Jun 20; 9. PMID: 31214499    Free PMC article.
Highlights of the 16th St Gallen International Breast Cancer Conference, Vienna, Austria, 20-23 March 2019: personalised treatments for patients with early breast cancer.
Consuelo Morigi.
Ecancermedicalscience, 2019 Jul 10; 13. PMID: 31281421    Free PMC article.
Validation of a Risk Score Incorporating Tumor Characteristics into the American Joint Committee on Cancer Anatomic Stage for Breast Cancer.
Yi Heng Seow, Ru Xin Wong, +3 authors, Fuh Yong Wong.
J Breast Cancer, 2019 Jul 10; 22(2). PMID: 31281728    Free PMC article.
The Oncotype Dx Assay in ER-Positive, HER2-Negative Breast Cancer Patients: A Real Life Experience from a Single Cancer Center.
Stephane Thibodeau, Ioannis A Voutsadakis.
Eur J Breast Health, 2019 Jul 18; 15(3). PMID: 31312792    Free PMC article.
Cost effectiveness of Gene Expression Profiling in Patients with Early-Stage Breast Cancer in a Middle-Income Country, Turkey: Results of a Prospective Multicenter Study.
Vahit Özmen, Burcu Çakar, +7 authors, Pınar Saip.
Eur J Breast Health, 2019 Jul 18; 15(3). PMID: 31312795    Free PMC article.
Comparison of GenesWell BCT Score With Oncotype DX Recurrence Score for Risk Classification in Asian Women With Hormone Receptor-Positive, HER2-Negative Early Breast Cancer.
Mi Jeong Kwon, Jeong Eon Lee, +12 authors, Young Kee Shin.
Front Oncol, 2019 Aug 14; 9. PMID: 31404265    Free PMC article.
De-escalation yes, but not at the expense of efficacy: in defense of better treatment.
Charles L Shapiro.
NPJ Breast Cancer, 2019 Aug 21; 5. PMID: 31428678    Free PMC article.
Big Data Approaches in Heart Failure Research.
Jan D Lanzer, Florian Leuschner, +2 authors, Julio Saez-Rodriguez.
Curr Heart Fail Rep, 2020 Aug 13; 17(5). PMID: 32783147    Free PMC article.
Review.
Does the Sequence of Anthracycline and Taxane Matter? The NeoSAMBA Trial.
José Bines, Isabele A Small, +9 authors, Martin Bonamino.
Oncologist, 2020 Jun 02; 25(9). PMID: 32476183    Free PMC article.
Molecular characterization of breast cancer needle core biopsy specimens by the 21-gene Breast Recurrence Score test.
Debbie M Jakubowski, Helen Bailey, +7 authors, Frederick L Baehner.
J Surg Oncol, 2020 Jun 05;. PMID: 32497318    Free PMC article.
Luminal Breast Cancer: The Head of Janus in Breast Oncology.
Oleg Gluz.
Breast Care (Basel), 2020 Sep 29; 15(4). PMID: 32982641    Free PMC article.
Genomic Signatures in Luminal Breast Cancer.
Julian Puppe, Tabea Seifert, +3 authors, Wolfram Malter.
Breast Care (Basel), 2020 Sep 29; 15(4). PMID: 32982645    Free PMC article.
Review.
The role of adjuvant chemotherapy in stage I-III male breast cancer: a SEER-based analysis.
Wei-Ping Li, Hong-Fei Gao, +8 authors, Kun Wang.
Ther Adv Med Oncol, 2020 Oct 06; 12. PMID: 33014148    Free PMC article.
Do we still need breast cancer screening in the era of targeted therapies and precision medicine?
Rubina Manuela Trimboli, Paolo Giorgi Rossi, +4 authors, Francesco Sardanelli.
Insights Imaging, 2020 Sep 26; 11(1). PMID: 32975658    Free PMC article.
Review.
Clinical utility of genomic signatures in young breast cancer patients: a systematic review.
Cynthia Villarreal-Garza, Ana S Ferrigno, +3 authors, Hatem A Azim.
NPJ Breast Cancer, 2020 Oct 17; 6. PMID: 33062888    Free PMC article.
Review.
Inter-tumor genomic heterogeneity of breast cancers: comprehensive genomic profile of primary early breast cancers and relapses.
Caterina Fumagalli, Alberto Ranghiero, +8 authors, Massimo Barberis.
Breast Cancer Res, 2020 Oct 17; 22(1). PMID: 33059724    Free PMC article.
Question Prompt List to Support Patient-Provider Communication in the Use of the 21-Gene Recurrence Test: Feasibility, Acceptability, and Outcomes.
Jinani Jayasekera, Susan T Vadaparampil, +8 authors, Suzanne C O'Neill.
JCO Oncol Pract, 2020 May 29; 16(10). PMID: 32463763    Free PMC article.
Considerations for feature selection using gene pairs and applications in large-scale dataset integration, novel oncogene discovery, and interpretable cancer screening.
Laura Moody, Hong Chen, Yuan-Xiang Pan.
BMC Med Genomics, 2020 Oct 23; 13(Suppl 10). PMID: 33087122    Free PMC article.
Beyond Chemotherapies: Recent Strategies in Breast Cancer Treatment.
Arthur Foulon, Pierrick Theret, Lise Rodat-Despoix, Philippe Kischel.
Cancers (Basel), 2020 Sep 20; 12(9). PMID: 32947780    Free PMC article.
Review.
Gemcitabine as adjuvant chemotherapy in patients with high-risk early breast cancer-results from the randomized phase III SUCCESS-A trial.
Amelie de Gregorio, Lothar Häberle, +22 authors, Wolfgang Janni.
Breast Cancer Res, 2020 Oct 25; 22(1). PMID: 33097092    Free PMC article.
Should we target "intermediate expression" of HER2 in older estrogen receptor positive patients?
Yoshihisa Tokumaru, Lan Le, +4 authors, Kazuaki Takabe.
Transl Cancer Res, 2020 Oct 27; 9(7). PMID: 33102162    Free PMC article.
Integrated Multiparametric Radiomics and Informatics System for Characterizing Breast Tumor Characteristics with the OncotypeDX Gene Assay.
Michael A Jacobs, Christopher B Umbricht, +5 authors, Antonio C Wolff.
Cancers (Basel), 2020 Oct 01; 12(10). PMID: 32992569    Free PMC article.
Cost-effectiveness analyses demonstrate that observation is superior to sentinel lymph node biopsy for postmenopausal women with HR + breast cancer and negative axillary ultrasound.
Aubriana M McEvoy, Steven Poplack, +7 authors, William E Gillanders.
Breast Cancer Res Treat, 2020 Jul 12; 183(2). PMID: 32651755    Free PMC article.
Review.
Patient and physician factors associated with Oncotype DX and adjuvant chemotherapy utilization for breast cancer patients in New Hampshire, 2010-2016.
Thomas M Schwedhelm, Judy R Rees, +4 authors, Erika L Moen.
BMC Cancer, 2020 Sep 05; 20(1). PMID: 32883270    Free PMC article.
Racial and ethnic disparities in 21-gene recurrence scores, chemotherapy, and survival among women with hormone receptor-positive, node-negative breast cancer.
Yunan Han, Zhi-Feng Miao, +3 authors, Ying Liu.
Breast Cancer Res Treat, 2020 Sep 16; 184(3). PMID: 32929567    Free PMC article.
Landmark trials in the medical oncology management of early stage breast cancer.
Whitney Hensing, Cesar A Santa-Maria, Lindsay L Peterson, Jennifer Y Sheng.
Semin Oncol, 2020 Sep 17; 47(5). PMID: 32933761    Free PMC article.
Review.
Update Breast Cancer 2020 Part 3 - Early Breast Cancer.
Jens Huober, Andreas Schneeweiss, +16 authors, Achim Wöckel.
Geburtshilfe Frauenheilkd, 2020 Nov 12; 80(11). PMID: 33173238    Free PMC article.
Artificial intelligence in oncology, its scope and future prospects with specific reference to radiation oncology.
Rajit Rattan, Tejinder Kataria, +6 authors, Saumya Ranjan Mishra.
BJR Open, 2019 May 13; 1(1). PMID: 33178922    Free PMC article.
Review.
Comparison of breast cancer prognostic tests CanAssist Breast and Oncotype DX.
Aditya K Sengupta, Aparna Gunda, +4 authors, Manjiri M Bakre.
Cancer Med, 2020 Oct 08; 9(21). PMID: 33027559    Free PMC article.
MYC Targets Scores Are Associated with Cancer Aggressiveness and Poor Survival in ER-Positive Primary and Metastatic Breast Cancer.
Amy Schulze, Masanori Oshi, Itaru Endo, Kazuaki Takabe.
Int J Mol Sci, 2020 Nov 05; 21(21). PMID: 33143224    Free PMC article.
What happened to the US cancer cooperative groups? A status update ten years after the Institute of Medicine report.
Monica M Bertagnolli, Charles D Blanke, +5 authors, Norman Wolmark.
Cancer, 2020 Sep 25; 126(23). PMID: 32970346    Free PMC article.
Review.
Immune responses during neoadjuvant chemotherapy in triple negative breast cancer.
Ahmed Ghallab.
EXCLI J, 2020 Nov 17; 19. PMID: 33192212    Free PMC article.
Oncotype DX Breast Recurrence Score Distribution and Chemotherapy Benefit Among Women of Different Age Groups With HR-Positive, HER2-Negative, Node-Negative Breast Cancer in the SEER Database.
Ran Cheng, Xiangyi Kong, +2 authors, Jing Wang.
Front Oncol, 2020 Nov 17; 10. PMID: 33194568    Free PMC article.
WNT4 secreted by tumor tissues promotes tumor progression in colorectal cancer by activation of the Wnt/β-catenin signalling pathway.
Dongmei Yang, Qing Li, +12 authors, Honggang Yu.
J Exp Clin Cancer Res, 2020 Nov 24; 39(1). PMID: 33222684    Free PMC article.
Side effects of adjuvant chemotherapy and their impact on outcome in elderly breast cancer patients: a cohort study.
Valentina Zanuso, Vittorio Fregoni, Lorenzo Gervaso.
Future Sci OA, 2020 Nov 26; 6(9). PMID: 33235809    Free PMC article.
Combined the SMAC mimetic and BCL2 inhibitor sensitizes neoadjuvant chemotherapy by targeting necrosome complexes in tyrosine aminoacyl-tRNA synthase-positive breast cancer.
Kyung-Min Lee, Hyebin Lee, +9 authors, Han Suk Ryu.
Breast Cancer Res, 2020 Nov 27; 22(1). PMID: 33239070    Free PMC article.
The association of socioeconomic status with receipt of neoadjuvant chemotherapy.
Joan M Neuner, Amanda Kong, +5 authors, Mary Schroeder.
Breast Cancer Res Treat, 2018 Sep 21; 173(1). PMID: 30232683    Free PMC article.
Validation of the 21-gene test as a predictor of clinical response to neoadjuvant hormonal therapy for ER+, HER2-negative breast cancer: the TransNEOS study.
Hiroji Iwata, Norikazu Masuda, +19 authors, Yasuo Ohashi.
Breast Cancer Res Treat, 2018 Sep 23; 173(1). PMID: 30242578    Free PMC article.
Multifocal/Multicentric Ipsilateral Invasive Breast Carcinomas with Similar Histology: Is Multigene Testing of All Individual Foci Necessary?
Anne Grabenstetter, Edi Brogi, +4 authors, Hannah Y Wen.
Ann Surg Oncol, 2018 Oct 10; 26(2). PMID: 30298311    Free PMC article.
The impact of gene expression profile testing on confidence in chemotherapy decisions and prognostic expectations.
Laura Panattoni, Tracy A Lieu, +5 authors, Scott D Ramsey.
Breast Cancer Res Treat, 2018 Oct 12; 173(2). PMID: 30306429    Free PMC article.
A Nomogram for Predicting the Oncotype DX Recurrence Score in Women with T1-3N0-1miM0 Hormone Receptor‒Positive, Human Epidermal Growth Factor 2 (HER2)‒Negative Breast Cancer.
Sae Byul Lee, Junetae Kim, +8 authors, Kyung Hae Jung.
Cancer Res Treat, 2018 Nov 06; 51(3). PMID: 30384581    Free PMC article.
SEOM clinical guidelines in early stage breast cancer (2018).
F Ayala de la Peña, R Andrés, +7 authors, E Ciruelos.
Clin Transl Oncol, 2018 Nov 18; 21(1). PMID: 30443868    Free PMC article.
Management of young women with early breast cancer.
Francesca Poggio, Matteo Lambertini, +6 authors, Lucia Del Mastro.
ESMO Open, 2018 Dec 19; 3(Suppl 1). PMID: 30559981    Free PMC article.
Systemic treatment and radiotherapy, breast cancer subtypes, and survival after long-term clinical follow-up.
Sherry X Yang, Eric C Polley.
Breast Cancer Res Treat, 2019 Feb 13; 175(2). PMID: 30746635    Free PMC article.
Ten Thousand Consecutive Gastrectomies for Gastric Cancer: Perspectives of a Master Surgeon.
Yoon Young Choi, Minah Cho, +5 authors, Woo Jin Hyung.
Yonsei Med J, 2019 Feb 26; 60(3). PMID: 30799586    Free PMC article.
Review.
Major clinical research advances in gynecologic cancer in 2018.
Miseon Kim, Dong Hoon Suh, +4 authors, Jae Weon Kim.
J Gynecol Oncol, 2019 Feb 26; 30(2). PMID: 30806045    Free PMC article.
Review.
[Update of the German S3 breast cancer guideline : What is new for pathologists?]
A Lebeau, C Denkert, +2 authors, A Wöckel.
Pathologe, 2019 Mar 09; 40(2). PMID: 30847505
Communicating prognosis to women with early breast cancer - overview of prediction tools and the development and pilot testing of a decision aid.
Viktoria Mühlbauer, Birte Berger-Höger, +2 authors, Anke Steckelberg.
BMC Health Serv Res, 2019 Mar 17; 19(1). PMID: 30876414    Free PMC article.
Systematic Review.
Update Breast Cancer 2019 Part 1 - Implementation of Study Results of Novel Study Designs in Clinical Practice in Patients with Early Breast Cancer.
Andreas D Hartkopf, Volkmar Müller, +14 authors, Hans Tesch.
Geburtshilfe Frauenheilkd, 2019 Mar 19; 79(3). PMID: 30880824    Free PMC article.
Update Breast Cancer 2019 Part 2 - Implementation of Novel Diagnostics and Therapeutics in Advanced Breast Cancer Patients in Clinical Practice.
Wolfgang Janni, Andreas Schneeweiss, +14 authors, Johannes Ettl.
Geburtshilfe Frauenheilkd, 2019 Mar 19; 79(3). PMID: 30880825    Free PMC article.
Prediction of chemotherapy benefit by EndoPredict in patients with breast cancer who received adjuvant endocrine therapy plus chemotherapy or endocrine therapy alone.
Ivana Sestak, Miguel Martín, +12 authors, Michael Gnant.
Breast Cancer Res Treat, 2019 May 02; 176(2). PMID: 31041683    Free PMC article.
Update Breast Cancer 2019 Part 3 - Current Developments in Early Breast Cancer: Review and Critical Assessment by an International Expert Panel.
Hans-Christian Kolberg, Andreas Schneeweiss, +18 authors, Sara Y Brucker.
Geburtshilfe Frauenheilkd, 2019 Jun 01; 79(5). PMID: 31148847    Free PMC article.
Is Routine Recurrence Score Testing in Patients Older than 70 Years of Age Warranted? An Evaluation of the National Cancer Database After TAILORx.
Rachel M Lee, Jeffrey M Switchenko, +3 authors, Preeti D Subhedar.
Ann Surg Oncol, 2019 Jul 26; 26(10). PMID: 31342377    Free PMC article.
Artificial intelligence-directed prognostication of breast cancer.
Azadeh Nasrazadani, Adam M Brufsky.
EBioMedicine, 2019 Aug 06; 46. PMID: 31378696    Free PMC article.
Genomics applied to the treatment of breast cancer.
Diaddin Hamdan, Thi Thuy Nguyen, +3 authors, Guilhem Bousquet.
Oncotarget, 2019 Aug 16; 10(46). PMID: 31413819    Free PMC article.
Review.
Reimagining T Staging Through Artificial Intelligence and Machine Learning Image Processing Approaches in Digital Pathology.
Kaustav Bera, Ian Katz, Anant Madabhushi.
JCO Clin Cancer Inform, 2020 Nov 10; 4. PMID: 33166198    Free PMC article.
The run-in phase of the prospective WSG-ADAPT HR+/HER2- trial demonstrates the feasibility of a study design combining static and dynamic biomarker assessments for individualized therapy in early breast cancer.
Ulrike Nitz, Oleg Gluz, +19 authors, Nadia Harbeck.
Ther Adv Med Oncol, 2020 Dec 08; 12. PMID: 33281950    Free PMC article.
Residual Axillary Burden After Neoadjuvant Chemotherapy (NACT) in Early Breast Cancer in Patients with a priori Clinically Occult Nodal Metastases - a transSENTINA Analysis.
Hans-Christian Kolberg, Thorsten Kühn, +13 authors, Cornelia Kolberg-Liedtke.
Geburtshilfe Frauenheilkd, 2020 Dec 10; 80(12). PMID: 33293731    Free PMC article.
Intratumoral heterogeneity of second-harmonic generation scattering from tumor collagen and its effects on metastatic risk prediction.
Danielle E Desa, Robert L Strawderman, +5 authors, Edward B Brown.
BMC Cancer, 2020 Dec 12; 20(1). PMID: 33302909    Free PMC article.
[Cognitive impairment in patients with early breast cancer receiving adjuvant systemic therapy: results from a substudy of the TAILORx trial].
Rainer Souchon.
Strahlenther Onkol, 2020 Oct 04; 196(12). PMID: 33009622
Impact of Commercialized Genomic Tests on Adjuvant Treatment Decisions in Early Stage Breast Cancer Patients.
Hazem I Assi, Ibrahim A Alameh, +9 authors, Nagi El Saghir.
J Oncol, 2020 Dec 15; 2020. PMID: 33312202    Free PMC article.
I-SPY 2: a Neoadjuvant Adaptive Clinical Trial Designed to Improve Outcomes in High-Risk Breast Cancer.
Haiyun Wang, Douglas Yee.
Curr Breast Cancer Rep, 2020 Dec 15; 11(4). PMID: 33312344    Free PMC article.
A Prognostic Gene-Expression Signature and Risk Score for Meningioma Recurrence After Resection.
William C Chen, Harish N Vasudevan, +16 authors, David R Raleigh.
Neurosurgery, 2020 Aug 30; 88(1). PMID: 32860417    Free PMC article.
Blood molecular markers associated with COVID-19 immunopathology and multi-organ damage.
Yan-Mei Chen, Yuanting Zheng, +24 authors, Yong-Zhen Zhang.
EMBO J, 2020 Nov 04; 39(24). PMID: 33140861    Free PMC article.
Predictability of 21-Gene Recurrence Score Assay by Using Pathological and Immunohistochemical Parameters in Breast Cancer.
Abdulmohsen Alkushi, Ahmad Omair, +2 authors, Omalkhair Abualkhair.
Breast Cancer (Auckl), 2020 Dec 22; 14. PMID: 33343196    Free PMC article.
Ki67 Immunohistochemistry Quantification in Breast Carcinoma: A Comparison of Visual Estimation, Counting, and ImmunoRatio.
Eunice J van den Berg, Raquel Duarte, +2 authors, Reena Mohanlal.
Appl Immunohistochem Mol Morphol, 2020 Jun 27; 29(2). PMID: 32590453    Free PMC article.
The molecular landscape of Asian breast cancers reveals clinically relevant population-specific differences.
Jia-Wern Pan, Muhammad Mamduh Ahmad Zabidi, +10 authors, Soo-Hwang Teo.
Nat Commun, 2020 Dec 24; 11(1). PMID: 33353943    Free PMC article.
Update on the most promising biomarkers of response to immune checkpoint inhibitors in clear cell renal cell carcinoma.
Ivan Pourmir, Johanna Noel, +2 authors, Yann-Alexandre Vano.
World J Urol, 2021 Jan 03;. PMID: 33386948
Residual risk stratification of Taiwanese breast cancers following curative therapies with the extended concurrent genes signature.
Ching-Shui Huang, Tzu-Pin Lu, +5 authors, Chi-Cheng Huang.
Breast Cancer Res Treat, 2021 Jan 05;. PMID: 33392837
The implementation of a commercially available multi-gene profile test for breast cancer characterization in a department of pathology: what have we learned from the first 100 cases?
Cristina Pelliccia, Emanuele Caselli, +3 authors, Angelo Sidoni.
Virchows Arch, 2021 Jan 07;. PMID: 33404851
Invasive lobular carcinoma of the breast: the increasing importance of this special subtype.
Amy E McCart Reed, Lauren Kalinowski, Peter T Simpson, Sunil R Lakhani.
Breast Cancer Res, 2021 Jan 09; 23(1). PMID: 33413533    Free PMC article.
Review.
Feasibility of Measuring Preferences for Chemotherapy Among Early-Stage Breast Cancer Survivors Using a Direct Rank Ordering Multicriteria Decision Analysis Versus a Time Trade-Off.
Laura Panattoni, Charles E Phelps, +4 authors, Scott D Ramsey.
Patient, 2020 May 25; 13(5). PMID: 32447608
A novel immune prognostic index for stratification of high-risk patients with early breast cancer.
Hannah Lee, Mi Jeong Kwon, +3 authors, Young Kee Shin.
Sci Rep, 2021 Jan 10; 11(1). PMID: 33420250    Free PMC article.
The Changing Role of Gene-Expression Profiling in the Era of De-escalating Adjuvant Chemotherapy in Early-Stage Breast Cancer.
J E C van Steenhoven, A Kuijer, +5 authors, T van Dalen.
Ann Surg Oncol, 2019 Jun 19; 26(11). PMID: 31209664    Free PMC article.
Chemotherapy and 21-gene recurrence score testing for older breast cancer patients: A competing-risks analysis.
Ping Zhou, Wen-Wen Zhang, +4 authors, San-Gang Wu.
Breast, 2020 Dec 06; 54. PMID: 33278648    Free PMC article.
Factors That Predict Biological Aggressiveness in Estrogen Receptor-Positive / Human Epidermal Growth Factor Receptor 2-Negative / Lymph Node-Negative Breast Cancer.
Lauren E Arthur, Ashley H McMann, +4 authors, Ralph L Corsetti.
Ochsner J, 2021 Jan 08; 20(4). PMID: 33408575    Free PMC article.
Tryptophanyl-tRNA Synthetase Sensitizes Hormone Receptor-Positive Breast Cancer to Docetaxel-Based Chemotherapy.
Kyung-Min Lee, Eun Hye Hwang, +6 authors, Han Suk Ryu.
J Breast Cancer, 2021 Jan 08; 23(6). PMID: 33408886    Free PMC article.
Predicted Chemotherapy Benefit for Breast Cancer Patients With Germline Pathogenic Variants in Cancer Susceptibility Genes.
Allison W Kurian, Kevin C Ward, +2 authors, Steven J Katz.
JNCI Cancer Spectr, 2021 Jan 12; 5(1). PMID: 33426465    Free PMC article.
Concordance of the 21-gene assay between core needle biopsy and resection specimens in early breast cancer patients.
Peng Qi, Yu Yang, +5 authors, Xiao-Yan Zhou.
Breast Cancer Res Treat, 2021 Jan 14;. PMID: 33439420    Free PMC article.
Magee Equations™ and response to neoadjuvant chemotherapy in ER+/HER2-negative breast cancer: a multi-institutional study.
Rohit Bhargava, Nicole N Esposito, +11 authors, David J Dabbs.
Mod Pathol, 2020 Jul 15; 34(1). PMID: 32661297
Adjuvant Chemotherapy for Patients with Breast Cancer Based on Clinical and Evolving Oncotype DX Criteria.
Jamal Zekri, Meteb Al-Foheidi, +2 authors, Ayman Rasmy.
Breast Care (Basel), 2021 Jan 16; 15(6). PMID: 33447239    Free PMC article.
Podoplanin expression in cancer-associated fibroblasts predicts unfavorable prognosis in node-negative breast cancer patients with hormone receptor-positive/HER2 - negative subtype.
Yuko Tanaka, Takashi Ohno, +7 authors, Yoshihisa Umekita.
Breast Cancer, 2021 Jan 23;. PMID: 33481184
Tumor Microenvironment Features as Predictive Biomarkers of Response to Immune Checkpoint Inhibitors (ICI) in Metastatic Clear Cell Renal Cell Carcinoma (mccRCC).
Audrey Simonaggio, Nicolas Epaillard, +3 authors, Yann-Alexandre Vano.
Cancers (Basel), 2021 Jan 14; 13(2). PMID: 33435262    Free PMC article.
Review.
Molecular downstaging: a new paradigm for neoadjuvant endocrine therapy.
Emanuela Ferraro, Monica N Fornier.
Ann Transl Med, 2021 Jan 26; 8(24). PMID: 33490206    Free PMC article.
Oncotype DX testing in node-positive breast cancer strongly impacts chemotherapy use at a comprehensive cancer center.
Katya Losk, Rachel A Freedman, +7 authors, Tari A King.
Breast Cancer Res Treat, 2020 Sep 18; 185(1). PMID: 32939592
Standard Anthracycline Based Versus Docetaxel-Capecitabine in Early High Clinical and/or Genomic Risk Breast Cancer in the EORTC 10041/BIG 3-04 MINDACT Phase III Trial.
Suzette Delaloge, Martine Piccart, +27 authors, MINDACT investigators and the TRANSBIG Consortium.
J Clin Oncol, 2020 Feb 23; 38(11). PMID: 32083990    Free PMC article.
Association of Race/Ethnicity and the 21-Gene Recurrence Score With Breast Cancer-Specific Mortality Among US Women.
Kent F Hoskins, Oana C Danciu, Naomi Y Ko, Gregory S Calip.
JAMA Oncol, 2021 Jan 22;. PMID: 33475714    Free PMC article.
In modern times, how important are breast cancer stage, grade and receptor subtype for survival: a population-based cohort study.
Anna L V Johansson, Cassia B Trewin, +3 authors, Giske Ursin.
Breast Cancer Res, 2021 Feb 03; 23(1). PMID: 33526044    Free PMC article.
Characterizing patient-oncologist communication in genomic tumor testing: The 21-gene recurrence score as an exemplar.
Suzanne C O'Neill, Susan T Vadaparampil, +9 authors, Susan Eggly.
Patient Educ Couns, 2020 Sep 10; 104(2). PMID: 32900604    Free PMC article.
Mucinous carcinoma with micropapillary features is morphologically, clinically and genetically distinct from pure mucinous carcinoma of breast.
Peng Sun, Zaixuan Zhong, +6 authors, Jiehua He.
Mod Pathol, 2020 May 03; 33(10). PMID: 32358590
Concordance between results of inexpensive statistical models and multigene signatures in patients with ER+/HER2- early breast cancer.
Laurence Slembrouck, Isabelle Vanden Bempt, +12 authors, Giuseppe Floris.
Mod Pathol, 2021 Feb 10;. PMID: 33558657
Adaptation of international coronavirus disease 2019 and breast cancer guidelines to local context.
Guillermo Arturo Valencia, Silvia Neciosup, +6 authors, Rodrigo Auqui.
World J Clin Oncol, 2021 Feb 09; 12(1). PMID: 33552937    Free PMC article.
Zinc distribution within breast cancer tissue of different intrinsic subtypes.
Peter Rusch, Alfred V Hirner, +3 authors, Maxim Diel.
Arch Gynecol Obstet, 2020 Sep 16; 303(1). PMID: 32930875    Free PMC article.
Tailoring precision immunotherapy: coming to a clinic soon?
Shuting Han, Wai Ho Shuen, +2 authors, Han Chong Toh.
ESMO Open, 2021 Feb 10; 5 Suppl 1. PMID: 33558033    Free PMC article.
Review.
FGFR1 amplification or overexpression and hormonal resistance in luminal breast cancer: rationale for a triple blockade of ER, CDK4/6, and FGFR1.
Silvana Mouron, Luis Manso, +6 authors, Maria J Bueno.
Breast Cancer Res, 2021 Feb 14; 23(1). PMID: 33579347    Free PMC article.
Current Achievements and Applications of Transcriptomics in Personalized Cancer Medicine.
Stanislaw Supplitt, Pawel Karpinski, Maria Sasiadek, Izabela Laczmanska.
Int J Mol Sci, 2021 Feb 13; 22(3). PMID: 33572595    Free PMC article.
Review.
Concordance of the molecular subtype classification between core needle biopsy and surgical specimen in primary breast cancer.
M Pölcher, M Braun, +6 authors, O Stoetzer.
Arch Gynecol Obstet, 2021 Feb 16;. PMID: 33585986
Deep learning in cancer pathology: a new generation of clinical biomarkers.
Amelie Echle, Niklas Timon Rindtorff, +3 authors, Jakob Nikolas Kather.
Br J Cancer, 2020 Nov 19; 124(4). PMID: 33204028
Review.
Targeting transcription of MCL-1 sensitizes HER2-amplified breast cancers to HER2 inhibitors.
Konstantinos V Floros, Sheeba Jacob, +8 authors, Anthony C Faber.
Cell Death Dis, 2021 Feb 17; 12(2). PMID: 33589591
Proteomic analysis of circulating extracellular vesicles identifies potential markers of breast cancer progression, recurrence, and response.
Yaron Vinik, Francisco Gabriel Ortega, +6 authors, Sima Lev.
Sci Adv, 2020 Oct 04; 6(40). PMID: 33008904    Free PMC article.
The Role of Oncotype DX® Recurrence Score in Predicting Axillary Response After Neoadjuvant Chemotherapy in Breast Cancer.
Jaime A Pardo, Betty Fan, +5 authors, Ted A James.
Ann Surg Oncol, 2021 Jan 05; 28(3). PMID: 33393046
Postmenopausal Women with HR+/HER2- Early Breast Cancer, 1-3 Positive Nodes, and a Low Risk of Recurrence Can Safely Forego Chemotherapy.
Oncologist, 2021 Jan 06; 26 Suppl 2. PMID: 33399242    Free PMC article.
Recommendations from the European Commission Initiative on Breast Cancer for multigene testing to guide the use of adjuvant chemotherapy in patients with early breast cancer, hormone receptor positive, HER-2 negative.
Paolo Giorgi Rossi, Annette Lebeau, +13 authors, ECIBC Contributor Group.
Br J Cancer, 2021 Feb 19;. PMID: 33597715
Review.
Refining breast cancer prognosis by incorporating age at diagnosis into clinical prognostic staging: introduction of a novel online calculator.
Helen M Johnson, William Irish, Nasreen A Vohra, Jan H Wong.
Breast Cancer Res Treat, 2021 Feb 21;. PMID: 33609208
A nomogram to predict the high-risk RS in HR+/HER2-breast cancer patients older than 50 years of age.
Jing Yu, Jiayi Wu, +6 authors, Kunwei Shen.
J Transl Med, 2021 Feb 18; 19(1). PMID: 33593381    Free PMC article.
Background Parenchymal Enhancement on Breast MRI as a Prognostic Surrogate: Correlation With Breast Cancer Oncotype Dx Score.
Michelle Zhang, Meredith Sadinski, +5 authors, Elizabeth J Sutton.
Front Oncol, 2021 Feb 23; 10. PMID: 33614481    Free PMC article.