Review
. 2018 Aug; 8(9):1069-1086.
doi: 10.1158/2159-8290.CD-18-0367.

Fundamental Mechanisms of Immune Checkpoint Blockade Therapy

Spencer C Wei 1 Colm R Duffy 2 James P Allison 1 
Affiliations
  • PMID: 30115704
  •     846 citations

Abstract

Immune checkpoint blockade is able to induce durable responses across multiple types of cancer, which has enabled the oncology community to begin to envision potentially curative therapeutic approaches. However, the remarkable responses to immunotherapies are currently limited to a minority of patients and indications, highlighting the need for more effective and novel approaches. Indeed, an extraordinary amount of preclinical and clinical investigation is exploring the therapeutic potential of negative and positive costimulatory molecules. Insights into the underlying biological mechanisms and functions of these molecules have, however, lagged significantly behind. Such understanding will be essential for the rational design of next-generation immunotherapies. Here, we review the current state of our understanding of T-cell costimulatory mechanisms and checkpoint blockade, primarily of CTLA4 and PD-1, and highlight conceptual gaps in knowledge.Significance: This review provides an overview of immune checkpoint blockade therapy from a basic biology and immunologic perspective for the cancer research community. Cancer Discov; 8(9); 1069-86. ©2018 AACR.

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LPA5 Is an Inhibitory Receptor That Suppresses CD8 T-Cell Cytotoxic Function via Disruption of Early TCR Signaling.
Divij Mathew, Kimberly N Kremer, +3 authors, Raul M Torres.
Front Immunol, 2019 Jun 25; 10. PMID: 31231367    Free PMC article.
Biomaterials as Tools to Decode Immunity.
Haleigh B Eppler, Christopher M Jewell.
Adv Mater, 2019 Nov 30; 32(13). PMID: 31782844    Free PMC article.
Review.
Personal tumor antigens in blood malignancies: genomics-directed identification and targeting.
Livius Penter, Catherine J Wu.
J Clin Invest, 2020 Jan 28; 130(4). PMID: 31985488    Free PMC article.
Review.
SUV39H1 regulates human colon carcinoma apoptosis and cell cycle to promote tumor growth.
Chunwan Lu, John D Klement, +4 authors, Kebin Liu.
Cancer Lett, 2020 Feb 18; 476. PMID: 32061753    Free PMC article.
Immune Checkpoint Axes Are Dysregulated in Patients With Alcoholic Hepatitis.
Wei Li, Ying Xia, +8 authors, Qigui Yu.
Hepatol Commun, 2020 Apr 08; 4(4). PMID: 32258953    Free PMC article.
Immunology's Coming of Age.
Stefan H E Kaufmann.
Front Immunol, 2019 Apr 20; 10. PMID: 31001278    Free PMC article.
Review.
FcγR-Binding Is an Important Functional Attribute for Immune Checkpoint Antibodies in Cancer Immunotherapy.
Xin Chen, Xiaomin Song, Kang Li, Tong Zhang.
Front Immunol, 2019 Mar 14; 10. PMID: 30863404    Free PMC article.
Highly Cited. Review.
Decoding the Role of Interleukin-30 in the Crosstalk Between Cancer and Myeloid Cells.
Emma Di Carlo.
Cells, 2020 Mar 08; 9(3). PMID: 32143355    Free PMC article.
Review.
Immunotherapy, Inflammation and Colorectal Cancer.
Charles Robert Lichtenstern, Rachael Katie Ngu, Shabnam Shalapour, Michael Karin.
Cells, 2020 Mar 08; 9(3). PMID: 32143413    Free PMC article.
Review.
Adoptive Cell Therapy-Harnessing Antigen-Specific T Cells to Target Solid Tumours.
Elżbieta Chruściel, Zuzanna Urban-Wójciuk, +10 authors, Natalia Marek-Trzonkowska.
Cancers (Basel), 2020 Mar 19; 12(3). PMID: 32183246    Free PMC article.
Review.
NK Cell Dysfunction and Checkpoint Immunotherapy.
Jiacheng Bi, Zhigang Tian.
Front Immunol, 2019 Sep 26; 10. PMID: 31552017    Free PMC article.
Review.
4-1BB Delineates Distinct Activation Status of Exhausted Tumor-Infiltrating CD8+ T Cells in Hepatocellular Carcinoma.
Hyung-Don Kim, Seongyeol Park, +15 authors, Su-Hyung Park.
Hepatology, 2019 Jul 30; 71(3). PMID: 31353502    Free PMC article.
Immune Conversion of Tumor Microenvironment by Oncolytic Viruses: The Protoparvovirus H-1PV Case Study.
Antonio Marchini, Laurent Daeffler, +2 authors, Jean Rommelaere.
Front Immunol, 2019 Aug 24; 10. PMID: 31440242    Free PMC article.
Review.
Programmed death ligand-1 is associated with tumor infiltrating lymphocytes and poorer survival in urothelial cell carcinoma of the bladder.
Bo Wang, Wenwei Pan, +7 authors, Tianxin Lin.
Cancer Sci, 2018 Dec 15; 110(2). PMID: 30548363    Free PMC article.
Discovery and Optimization of Rationally Designed Bicyclic Inhibitors of Human Arginase to Enhance Cancer Immunotherapy.
Matthew J Mitcheltree, Derun Li, +21 authors, Christian Fischer.
ACS Med Chem Lett, 2020 Apr 16; 11(4). PMID: 32292567    Free PMC article.
Carcinoembryonic Antigen (CEA)-Specific 4-1BB-Costimulation Induced by CEA-Targeted 4-1BB-Agonistic Trimerbodies.
Kasper Mikkelsen, Seandean Lykke Harwood, +6 authors, Luis Álvarez-Vallina.
Front Immunol, 2019 Aug 17; 10. PMID: 31417564    Free PMC article.
Cytotoxic Chemotherapy as an Immune Stimulus: A Molecular Perspective on Turning Up the Immunological Heat on Cancer.
James W Opzoomer, Dominika Sosnowska, +2 authors, James N Arnold.
Front Immunol, 2019 Aug 06; 10. PMID: 31379850    Free PMC article.
Review.
Novel risk group stratification for metastatic urothelial cancer patients treated with immune checkpoint inhibitors.
Julie M Shabto, Dylan J Martini, +13 authors, Mehmet A Bilen.
Cancer Med, 2020 Feb 27; 9(8). PMID: 32100417    Free PMC article.
Role of inflammasome activation in tumor immunity triggered by immune checkpoint blockers.
M Segovia, S Russo, +2 authors, M Hill.
Clin Exp Immunol, 2020 Apr 17; 200(2). PMID: 32297328    Free PMC article.
Review.
Diversity, Mechanisms, and Significance of Macrophage Plasticity.
Massimo Locati, Graziella Curtale, Alberto Mantovani.
Annu Rev Pathol, 2019 Sep 19; 15. PMID: 31530089    Free PMC article.
Highly Cited. Review.
Sex-associated molecular differences for cancer immunotherapy.
Youqiong Ye, Ying Jing, +4 authors, Leng Han.
Nat Commun, 2020 Apr 15; 11(1). PMID: 32286310    Free PMC article.
Characterization of human cancer xenografts in humanized mice.
Jonathan Rios-Doria, Christina Stevens, +2 authors, Holly K Koblish.
J Immunother Cancer, 2020 Mar 29; 8(1). PMID: 32217760    Free PMC article.
Differential Targeting of Gr-MDSCs, T Cells and Prostate Cancer Cells by Dactolisib and Dasatinib.
Guoqiang Liu, Zhijian Jin, Xin Lu.
Int J Mol Sci, 2020 Apr 02; 21(7). PMID: 32230980    Free PMC article.
Programmed Cell Death-1: Programmed Cell Death-Ligand 1 Interaction Protects Human Cardiomyocytes Against T-Cell Mediated Inflammation and Apoptosis Response In Vitro.
Woan Ting Tay, Yi-Hsien Fang, +4 authors, Ping-Yen Liu.
Int J Mol Sci, 2020 Apr 05; 21(7). PMID: 32244307    Free PMC article.
Tumor Milieu Controlled by RB Tumor Suppressor.
Shunsuke Kitajima, Fengkai Li, Chiaki Takahashi.
Int J Mol Sci, 2020 Apr 05; 21(7). PMID: 32244804    Free PMC article.
Review.
Current Insights into Combination Therapies with MAPK Inhibitors and Immune Checkpoint Blockade.
Min Hwa Shin, Jiyoung Kim, +2 authors, Kyung-Mi Lee.
Int J Mol Sci, 2020 Apr 09; 21(7). PMID: 32260561    Free PMC article.
Review.
Neurologic complications of immune checkpoint inhibitors.
Alexandra M Haugh, John C Probasco, Douglas B Johnson.
Expert Opin Drug Saf, 2020 Mar 04; 19(4). PMID: 32126176    Free PMC article.
Review.
Tumor Plasticity and Resistance to Immunotherapy.
Lucas A Horn, Kristen Fousek, Claudia Palena.
Trends Cancer, 2020 Apr 30; 6(5). PMID: 32348738    Free PMC article.
Review.
Concurrent therapy with immune checkpoint inhibitors and TNFα blockade in patients with gastrointestinal immune-related adverse events.
Yousef R Badran, Justine V Cohen, +3 authors, Michael Dougan.
J Immunother Cancer, 2019 Aug 24; 7(1). PMID: 31439050    Free PMC article.
Reactivation of tuberculosis in cancer patients following administration of immune checkpoint inhibitors: current evidence and clinical practice recommendations.
Amalia Anastasopoulou, Dimitrios C Ziogas, +2 authors, Helen Gogas.
J Immunother Cancer, 2019 Sep 06; 7(1). PMID: 31484550    Free PMC article.
Review.
Validation of the DNA Damage Immune Response Signature in Patients With Triple-Negative Breast Cancer From the SWOG 9313c Trial.
Priyanka Sharma, William E Barlow, +19 authors, Daniel F Hayes.
J Clin Oncol, 2019 Oct 29; 37(36). PMID: 31657982    Free PMC article.
HDAC Inhibitor, CG-745, Enhances the Anti-Cancer Effect of Anti-PD-1 Immune Checkpoint Inhibitor by Modulation of the Immune Microenvironment.
Young-Dae Kim, Sang-Min Park, +5 authors, Joong Myung Cho.
J Cancer, 2020 May 06; 11(14). PMID: 32368288    Free PMC article.
Immunotherapy for Medulloblastoma: Current Perspectives.
Tanvir F Kabir, Charles A Kunos, John L Villano, Aman Chauhan.
Immunotargets Ther, 2020 May 06; 9. PMID: 32368525    Free PMC article.
Review.
Killers 2.0: NK cell therapies at the forefront of cancer control.
Jonathan J Hodgins, Sarwat T Khan, +2 authors, Michele Ardolino.
J Clin Invest, 2019 Sep 04; 129(9). PMID: 31478911    Free PMC article.
Highly Cited. Review.
Preserving the CTLA-4 Checkpoint for Safer and More Effective Cancer Immunotherapy.
Yang Liu, Pan Zheng.
Trends Pharmacol Sci, 2019 Dec 15; 41(1). PMID: 31836191    Free PMC article.
Review.
Preclinical PET imaging of bispecific antibody ERY974 targeting CD3 and glypican 3 reveals that tumor uptake correlates to T cell infiltrate.
Stijn Jh Waaijer, Danique Giesen, +5 authors, Marjolijn N Lub-de Hooge.
J Immunother Cancer, 2020 Mar 29; 8(1). PMID: 32217763    Free PMC article.
Loss of BAP1 expression is associated with an immunosuppressive microenvironment in uveal melanoma, with implications for immunotherapy development.
Carlos R Figueiredo, Helen Kalirai, +5 authors, Sarah E Coupland.
J Pathol, 2020 Jan 22; 250(4). PMID: 31960425    Free PMC article.
FOLFOX Chemotherapy Ameliorates CD8 T Lymphocyte Exhaustion and Enhances Checkpoint Blockade Efficacy in Colorectal Cancer.
Yue Guan, Sean G Kraus, +3 authors, Emma Teixeiro.
Front Oncol, 2020 May 12; 10. PMID: 32391270    Free PMC article.
[New vaccines against tuberculosis].
Stefan H E Kaufmann.
Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz, 2019 Dec 01; 63(1). PMID: 31784764    Free PMC article.
Review.
Overcoming resistance to anti-PD1 and anti-PD-L1 treatment in gastrointestinal malignancies.
Alberto Puccini, Francesca Battaglin, +2 authors, Mohamed E Salem.
J Immunother Cancer, 2020 May 13; 8(1). PMID: 32393474    Free PMC article.
Review.
NK and NKT Cell-Mediated Immune Surveillance against Hematological Malignancies.
Kanako Shimizu, Tomonori Iyoda, +3 authors, And Shin-Ichiro Fujii.
Cancers (Basel), 2020 Apr 02; 12(4). PMID: 32231116    Free PMC article.
Review.
Fully Human Antibodies for Malignant Pleural Mesothelioma Targeting.
Fabio Nicolini, Martine Bocchini, +4 authors, Massimiliano Mazza.
Cancers (Basel), 2020 Apr 12; 12(4). PMID: 32276524    Free PMC article.
Review.
Mathematical prediction of clinical outcomes in advanced cancer patients treated with checkpoint inhibitor immunotherapy.
Joseph D Butner, Dalia Elganainy, +9 authors, Vittorio Cristini.
Sci Adv, 2020 May 20; 6(18). PMID: 32426472    Free PMC article.
CD81 is a novel immunotherapeutic target for B cell lymphoma.
Felipe Vences-Catalán, Chiung-Chi Kuo, +5 authors, Shoshana Levy.
J Exp Med, 2019 May 28; 216(7). PMID: 31123084    Free PMC article.
MHC-I genotype and tumor mutational burden predict response to immunotherapy.
Aaron M Goodman, Andrea Castro, +9 authors, Razelle Kurzrock.
Genome Med, 2020 May 21; 12(1). PMID: 32430031    Free PMC article.
Treatment of Metastatic Disease through Natural Killer Cell Modulation by Infected Cell Vaccines.
Seyedeh Raheleh Niavarani, Christine Lawson, Lee-Hwa Tai.
Viruses, 2019 May 15; 11(5). PMID: 31083491    Free PMC article.
Review.
Relevance of immune cell and tumor microenvironment imaging in the new era of immunotherapy.
Filippo Galli, Jesus Vera Aguilera, +3 authors, Alberto Signore.
J Exp Clin Cancer Res, 2020 May 20; 39(1). PMID: 32423420    Free PMC article.
Review.
Immunotherapy After Immunotherapy: Response Rescue in a Patient With Microsatellite Instability-high Colorectal Cancer Post-Pembrolizumab.
Satya Das, Audrey Allen, Jordan Berlin.
Clin Colorectal Cancer, 2020 Mar 09; 19(2). PMID: 32146081    Free PMC article.
Targeting Glycosylated PD-1 Induces Potent Antitumor Immunity.
Linlin Sun, Chia-Wei Li, +17 authors, Mien-Chie Hung.
Cancer Res, 2020 Mar 12; 80(11). PMID: 32156778    Free PMC article.
ACT001 reduces the expression of PD-L1 by inhibiting the phosphorylation of STAT3 in glioblastoma.
Luqing Tong, Jiabo Li, +16 authors, Xuejun Yang.
Theranostics, 2020 Jun 03; 10(13). PMID: 32483429    Free PMC article.
Severe immune thrombocytopenia induced by nivolumab in a patient with metastatic renal cell carcinoma.
Shinro Hata, Satoki Abe.
Urol Case Rep, 2020 Jun 04; 32. PMID: 32489885    Free PMC article.
Lifting the innate immune barriers to antitumor immunity.
Carla V Rothlin, Sourav Ghosh.
J Immunother Cancer, 2020 Apr 11; 8(1). PMID: 32273348    Free PMC article.
Review.
Single-cell RNA sequencing reveals the tumor microenvironment and facilitates strategic choices to circumvent treatment failure in a chemorefractory bladder cancer patient.
Hye Won Lee, Woosung Chung, +9 authors, Woong-Yang Park.
Genome Med, 2020 May 29; 12(1). PMID: 32460812    Free PMC article.
Calreticulin couples with immune checkpoints in pancreatic cancer.
Xing Huang, Tianyu Tang, +2 authors, Tingbo Liang.
Clin Transl Med, 2020 Jun 09; 10(1). PMID: 32508042    Free PMC article.
Immunologically modified MnFe2O4 nanoparticles to synergize photothermal therapy and immunotherapy for cancer treatment.
Benqing Zhou, Qiang Wu, +9 authors, Wei R Chen.
Chem Eng J, 2020 Jun 12; 396. PMID: 32523422    Free PMC article.
Immunotherapy in colorectal cancer: rationale, challenges and potential.
Karuna Ganesh, Zsofia K Stadler, +4 authors, Luis A Diaz.
Nat Rev Gastroenterol Hepatol, 2019 Mar 20; 16(6). PMID: 30886395    Free PMC article.
Highly Cited. Review.
Therapy-Induced MHC I Ligands Shape Neo-Antitumor CD8 T Cell Responses during Oncolytic Virus-Based Cancer Immunotherapy.
J Patrick Murphy, Youra Kim, +8 authors, Shashi Gujar.
J Proteome Res, 2019 May 17; 18(6). PMID: 31095916    Free PMC article.
Acquired Resistance to Immune Checkpoint Blockade Therapies.
Xianda Zhao, Dechen Wangmo, Matthew Robertson, Subbaya Subramanian.
Cancers (Basel), 2020 May 10; 12(5). PMID: 32380703    Free PMC article.
Review.
Advancing the Science and Management of Renal Cell Carcinoma: Bridging the Divide between Academic and Community Practices.
Nicholas J Salgia, Errol J Philip, +2 authors, Sumanta Kumar Pal.
J Clin Med, 2020 May 21; 9(5). PMID: 32429554    Free PMC article.
Adjuvant Effect of Toll-Like Receptor 9 Activation on Cancer Immunotherapy Using Checkpoint Blockade.
Yu-Chen Chuang, Jen-Chih Tseng, +3 authors, Tsung-Hsien Chuang.
Front Immunol, 2020 Jun 18; 11. PMID: 32547560    Free PMC article.
Review.
Immune Checkpoint Inhibitor-Induced Acute Pancreatitis and Colitis.
Andrea Pagan, Yadis M Arroyo-Martinez, +2 authors, Jeffrey Gill.
Cureus, 2020 Jun 19; 12(6). PMID: 32550093    Free PMC article.
Severe immune thrombocytopenia induced by a single dose of nivolumab in a patient with advanced non-small cell lung cancer.
Adam Khorasanchi, Roger Keresztes.
Clin Pract, 2020 Jun 26; 10(2). PMID: 32582418    Free PMC article.
NF-κB and Its Role in Checkpoint Control.
Annika C Betzler, Marie-Nicole Theodoraki, +4 authors, Cornelia Brunner.
Int J Mol Sci, 2020 Jun 04; 21(11). PMID: 32486375    Free PMC article.
Review.
Mouse Tumor Models for Advanced Cancer Immunotherapy.
Daria S Chulpanova, Kristina V Kitaeva, +2 authors, Valeriya V Solovyeva.
Int J Mol Sci, 2020 Jun 13; 21(11). PMID: 32526987    Free PMC article.
Review.
The Emerging Role of Exosomes in Diagnosis, Prognosis, and Therapy in Head and Neck Cancer.
Linda Hofmann, Sonja Ludwig, +3 authors, Marie-Nicole Theodoraki.
Int J Mol Sci, 2020 Jun 11; 21(11). PMID: 32517240    Free PMC article.
Review.
Infectious Complications of Biological and Small Molecule Targeted Immunomodulatory Therapies.
Joshua S Davis, David Ferreira, +2 authors, Michael Boyle.
Clin Microbiol Rev, 2020 Jun 12; 33(3). PMID: 32522746    Free PMC article.
Review.
Immune checkpoint inhibitor-associated celiac disease.
Yousef R Badran, Angela Shih, +9 authors, Michael Dougan.
J Immunother Cancer, 2020 Jun 26; 8(1). PMID: 32581063    Free PMC article.
Role of DNA repair defects in predicting immunotherapy response.
Jing Zhang, David J H Shih, Shiaw-Yih Lin.
Biomark Res, 2020 Jul 03; 8. PMID: 32612833    Free PMC article.
Review.
PD-L1 Expression Affects Neoantigen Presentation.
Masahiro Okada, Kanako Shimizu, +6 authors, Shin-Ichiro Fujii.
iScience, 2020 Jul 08; 23(6). PMID: 32629606    Free PMC article.
A Tale of Immune-Related Adverse Events With Sequential Trials of Checkpoint Inhibitors in a Patient With Metastatic Renal Cell Carcinoma.
Vinit Singh, Yvonne Chu, Varsha Gupta, Charlie Weige Zhao.
Cureus, 2020 Jul 09; 12(6). PMID: 32637277    Free PMC article.
Human ovarian cancer intrinsic mechanisms regulate lymphocyte activation in response to immune checkpoint blockade.
Marina Natoli, Nair Bonito, +2 authors, Yumeng Mao.
Cancer Immunol Immunother, 2020 Mar 23; 69(8). PMID: 32200422    Free PMC article.
Absence of central tolerance in Aire-deficient mice synergizes with immune-checkpoint inhibition to enhance antitumor responses.
Asiel A Benitez, Sara Khalil-Agüero, +6 authors, Sokol Haxhinasto.
Commun Biol, 2020 Jul 10; 3(1). PMID: 32641748    Free PMC article.
Flattening the COVID-19 Curve With Natural Killer Cell Based Immunotherapies.
Marisa Market, Leonard Angka, +7 authors, Rebecca C Auer.
Front Immunol, 2020 Jul 14; 11. PMID: 32655581    Free PMC article.
Review.
The Role of Tumor-Associated Myeloid Cells in Modulating Cancer Therapy.
Christiana M Neophytou, Chryso Pierides, +3 authors, Panagiotis Papageorgis.
Front Oncol, 2020 Jul 14; 10. PMID: 32656079    Free PMC article.
Review.
Impact of checkpoint blockade on cancer vaccine-activated CD8+ T cell responses.
Patricia M Santos, Juraj Adamik, +6 authors, Lisa H Butterfield.
J Exp Med, 2020 May 06; 217(7). PMID: 32369107    Free PMC article.
Innate Immune Cells and Their Contribution to T-Cell-Based Immunotherapy.
Pierpaolo Ginefra, Girieca Lorusso, Nicola Vannini.
Int J Mol Sci, 2020 Jun 26; 21(12). PMID: 32580431    Free PMC article.
Review.
Optimizing Oncolytic Viral Design to Enhance Antitumor Efficacy: Progress and Challenges.
Shyambabu Chaurasiya, Yuman Fong, Susanne G Warner.
Cancers (Basel), 2020 Jul 02; 12(6). PMID: 32604787    Free PMC article.
Review.
Development of canine PD-1/PD-L1 specific monoclonal antibodies and amplification of canine T cell function.
Jin Wook Choi, Sita S Withers, +10 authors, Stephen J McSorley.
PLoS One, 2020 Jul 03; 15(7). PMID: 32614928    Free PMC article.
Salvage Therapy With Multikinase Inhibitors and Immunotherapy in Advanced Adrenal Cortical Carcinoma.
Kevin C Miller, Ashish V Chintakuntlawar, +6 authors, Keith C Bible.
J Endocr Soc, 2020 Jul 16; 4(7). PMID: 32666013    Free PMC article.
Obesity and the Impact on Cutaneous Melanoma: Friend or Foe?
Lorey K Smith, Shaghayegh Arabi, +2 authors, Karen E Sheppard.
Cancers (Basel), 2020 Jun 19; 12(6). PMID: 32549336    Free PMC article.
Review.
Percutaneous Ablation-Induced Immunomodulation in Hepatocellular Carcinoma.
Lucile Dumolard, Julien Ghelfi, +2 authors, Zuzana Macek Jilkova.
Int J Mol Sci, 2020 Jun 25; 21(12). PMID: 32575734    Free PMC article.
Review.
Peptide vaccination directed against IDO1-expressing immune cells elicits CD8+ and CD4+ T-cell-mediated antitumor immunity and enhanced anti-PD1 responses.
Souvik Dey, Erika Sutanto-Ward, +10 authors, Alexander J Muller.
J Immunother Cancer, 2020 Jul 22; 8(2). PMID: 32690770    Free PMC article.
Influence of Androgens on Immunity to Self and Foreign: Effects on Immunity and Cancer.
Isabel Ben-Batalla, María Elena Vargas-Delgado, +2 authors, Sonja Loges.
Front Immunol, 2020 Jul 28; 11. PMID: 32714315    Free PMC article.
Review.
Cancer and HIV-1 Infection: Patterns of Chronic Antigen Exposure.
Selena Vigano, Sara Bobisse, +2 authors, Alexandre Harari.
Front Immunol, 2020 Jul 28; 11. PMID: 32714330    Free PMC article.
Review.
Cutaneous melanoma and the immunotherapy revolution (Review).
Giulia C Leonardi, Saverio Candido, +2 authors, Massimo Libra.
Int J Oncol, 2020 Jun 26; 57(3). PMID: 32582963    Free PMC article.
Review.
Pre-clinical studies of EC2629, a highly potent folate- receptor-targeted DNA crosslinking agent.
Joseph A Reddy, Melissa Nelson, +16 authors, Christopher P Leamon.
Sci Rep, 2020 Jul 31; 10(1). PMID: 32728172    Free PMC article.
Rewriting History: Epigenetic Reprogramming of CD8+ T Cell Differentiation to Enhance Immunotherapy.
Caitlin C Zebley, Stephen Gottschalk, Ben Youngblood.
Trends Immunol, 2020 Jul 07; 41(8). PMID: 32624330    Free PMC article.
Review.
Activation of CAR and non-CAR T cells within the tumor microenvironment following CAR T cell therapy.
Pei-Hsuan Chen, Mikel Lipschitz, +10 authors, Scott J Rodig.
JCI Insight, 2020 Jun 03; 5(12). PMID: 32484797    Free PMC article.
Obesity and CD8 T cell metabolism: Implications for anti-tumor immunity and cancer immunotherapy outcomes.
William J Turbitt, Claire Buchta Rosean, K Scott Weber, Lyse A Norian.
Immunol Rev, 2020 Mar 12; 295(1). PMID: 32157710    Free PMC article.
Review.
Epigenetic mechanisms and the hallmarks of cancer: an intimate affair.
Nadine Darwiche.
Am J Cancer Res, 2020 Aug 11; 10(7). PMID: 32774995    Free PMC article.
Review.
Virus-Specific T Cell Therapies for HIV: Lessons Learned From Hematopoietic Stem Cell Transplantation.
Ping-Hsien Lee, Michael D Keller, Patrick J Hanley, Catherine M Bollard.
Front Cell Infect Microbiol, 2020 Aug 11; 10. PMID: 32775304    Free PMC article.
Review.
Nanomedicine and Onco-Immunotherapy: From the Bench to Bedside to Biomarkers.
Vanessa Acebes-Fernández, Alicia Landeria-Viñuela, +5 authors, Manuel Fuentes.
Nanomaterials (Basel), 2020 Jul 03; 10(7). PMID: 32610601    Free PMC article.
Review.
Interferon-γ induced PD-L1 expression and soluble PD-L1 production in gastric cancer.
Yushi Imai, Tetsuhiro Chiba, +18 authors, Naoya Kato.
Oncol Lett, 2020 Aug 13; 20(3). PMID: 32782533    Free PMC article.
Resolving the HIF paradox in pancreatic cancer.
Natividad R Fuentes, Jae Phan, +2 authors, Cullen M Taniguchi.
Cancer Lett, 2020 Jun 09; 489. PMID: 32512024    Free PMC article.
Review.
A phase I study of toripalimab, an anti-PD-1 antibody, in patients with refractory malignant solid tumors.
Xiao-Li Wei, Chao Ren, +10 authors, Rui-Hua Xu.
Cancer Commun (Lond), 2020 Jun 27; 40(8). PMID: 32589350    Free PMC article.
Targeting immune checkpoints in hematological malignancies.
Basit Salik, Mark J Smyth, Kyohei Nakamura.
J Hematol Oncol, 2020 Aug 14; 13(1). PMID: 32787882    Free PMC article.
Review.
A Clinician's Guide to Cancer-Derived Exosomes: Immune Interactions and Therapeutic Implications.
Matthew C Knox, Jie Ni, +4 authors, Yong Li.
Front Immunol, 2020 Aug 15; 11. PMID: 32793238    Free PMC article.
Review.
The history and advances in cancer immunotherapy: understanding the characteristics of tumor-infiltrating immune cells and their therapeutic implications.
Yuanyuan Zhang, Zemin Zhang.
Cell Mol Immunol, 2020 Jul 03; 17(8). PMID: 32612154    Free PMC article.
Review.
Nephrotoxicity Associated with Novel Anticancer Agents (Aflibercept, Dasatinib, Nivolumab): Case Series and Nephrological Considerations.
Luca Piscitani, Vittorio Sirolli, +2 authors, Mario Bonomini.
Int J Mol Sci, 2020 Jul 16; 21(14). PMID: 32664269    Free PMC article.
Review.
Safety and efficacy of sintilimab combined with oxaliplatin/capecitabine as first-line treatment in patients with locally advanced or metastatic gastric/gastroesophageal junction adenocarcinoma in a phase Ib clinical trial.
Haiping Jiang, Yulong Zheng, +12 authors, Nong Xu.
BMC Cancer, 2020 Aug 17; 20(1). PMID: 32795349    Free PMC article.
Bone metastasis is associated with acquisition of mesenchymal phenotype and immune suppression in a model of spontaneous breast cancer metastasis.
Lea Monteran, Nour Ershaid, +7 authors, Neta Erez.
Sci Rep, 2020 Aug 17; 10(1). PMID: 32796899    Free PMC article.
Immune checkpoint inhibitor combination therapy for gastric cancer: Research progress.
Xiaoxu Song, Weiwei Qi, +6 authors, Jing Lv.
Oncol Lett, 2020 Aug 18; 20(4). PMID: 32802168    Free PMC article.
Review.
Interrogating Cellular Communication in Cancer with Genetically Encoded Imaging Reporters.
Seth T Gammon, Tracy W Liu, David Piwnica-Worms.
Radiol Imaging Cancer, 2020 Aug 18; 2(4). PMID: 32803164    Free PMC article.
Review.
IL-34, IL-36 and IL-38 in colorectal cancer-key immunoregulators of carcinogenesis.
Shisan Bao, Rong Hu, Brett D Hambly.
Biophys Rev, 2020 Jul 09; 12(4). PMID: 32638330    Free PMC article.
Review.
Genetic ablation of adipocyte PD-L1 reduces tumor growth but accentuates obesity-associated inflammation.
Bogang Wu, Huai-Chin Chiang, +5 authors, Rong Li.
J Immunother Cancer, 2020 Aug 21; 8(2). PMID: 32817394    Free PMC article.
Tumor Cell-Intrinsic Immunometabolism and Precision Nutrition in Cancer Immunotherapy.
Elisabet Cuyàs, Sara Verdura, +4 authors, Javier A Menendez.
Cancers (Basel), 2020 Jul 08; 12(7). PMID: 32630618    Free PMC article.
Harnessing the Complete Repertoire of Conventional Dendritic Cell Functions for Cancer Immunotherapy.
Lukas Amon, Lukas Hatscher, +2 authors, Christian H K Lehmann.
Pharmaceutics, 2020 Jul 18; 12(7). PMID: 32674488    Free PMC article.
Review.
A PoleP286R mouse model of endometrial cancer recapitulates high mutational burden and immunotherapy response.
Hao-Dong Li, Changzheng Lu, +15 authors, Diego H Castrillon.
JCI Insight, 2020 Jul 24; 5(14). PMID: 32699191    Free PMC article.
Cholangiocarcinoma 2020: the next horizon in mechanisms and management.
Jesus M Banales, Jose J G Marin, +31 authors, Gregory J Gores.
Nat Rev Gastroenterol Hepatol, 2020 Jul 02; 17(9). PMID: 32606456    Free PMC article.
Review.
Metastatic cutaneous squamous cell carcinoma responsive to cemiplimab in a patient with multiple myeloma.
Nareh Valerie Marukian, John Q Lin, +2 authors, Anne Lynn S Chang.
JAAD Case Rep, 2020 Sep 03; 6(9). PMID: 32875028    Free PMC article.
Integrative Approaches to Cancer Immunotherapy.
Gregory L Szeto, Stacey D Finley.
Trends Cancer, 2019 Jul 18; 5(7). PMID: 31311655    Free PMC article.
Review.
Nanomedicines based on nanoscale metal-organic frameworks for cancer immunotherapy.
Xiao-Fang Zhong, Xun Sun.
Acta Pharmacol Sin, 2020 May 02; 41(7). PMID: 32355277    Free PMC article.
Review.
Role of Immune Checkpoint Inhibitors in Gastrointestinal Malignancies.
Anita Mazloom, Nima Ghalehsari, +5 authors, Uqba Khan.
J Clin Med, 2020 Aug 13; 9(8). PMID: 32781500    Free PMC article.
Review.
Clinical and Pre-Clinical Evidence of Carbonic Anhydrase IX in Pancreatic Cancer and Its High Expression in Pre-Cancerous Lesions.
Sabina Strapcova, Martina Takacova, +5 authors, Eliska Svastova.
Cancers (Basel), 2020 Jul 28; 12(8). PMID: 32707920    Free PMC article.
Review.
Isolation of Two Novel Human Anti-CTLA-4 mAbs with Intriguing Biological Properties on Tumor and NK Cells.
Margherita Passariello, Cinzia Vetrei, +7 authors, Claudia De Lorenzo.
Cancers (Basel), 2020 Aug 13; 12(8). PMID: 32781690    Free PMC article.
Epidermal activation of Hedgehog signaling establishes an immunosuppressive microenvironment in basal cell carcinoma by modulating skin immunity.
Sandra Grund-Gröschke, Daniela Ortner, +11 authors, Fritz Aberger.
Mol Oncol, 2020 Jul 03; 14(9). PMID: 32615027    Free PMC article.
AMG 701 induces cytotoxicity of multiple myeloma cells and depletes plasma cells in cynomolgus monkeys.
Rebecca L Goldstein, Ana Goyos, +15 authors, Tara Arvedson.
Blood Adv, 2020 Sep 05; 4(17). PMID: 32886754    Free PMC article.
Coupled immune stratification and identification of therapeutic candidates in patients with lung adenocarcinoma.
Weilei Hu, Guosheng Wang, +3 authors, Yuan Wan.
Aging (Albany NY), 2020 Aug 29; 12(16). PMID: 32855362    Free PMC article.
Therapy of Primary Liver Cancer.
Mei Feng, Yisheng Pan, Ruirui Kong, Shaokun Shu.
Innovation (N Y), 2020 Sep 12; 1(2). PMID: 32914142    Free PMC article.
Review.
Regulation of the tumor immune microenvironment and vascular normalization in TNBC murine models by a novel peptide.
Adam C Mirando, Akash Patil, +6 authors, Aleksander S Popel.
Oncoimmunology, 2020 Sep 15; 9(1). PMID: 32923118    Free PMC article.
Cancer immunotherapy using a polysaccharide from Codium fragile in a murine model.
Hae-Bin Park, Seong-Min Lim, +3 authors, Jun-O Jin.
Oncoimmunology, 2020 Sep 15; 9(1). PMID: 32923129    Free PMC article.
Dose dependence of treatment-related adverse events for immune checkpoint inhibitor therapies: a model-based meta-analysis.
Boris Shulgin, Yuri Kosinsky, +8 authors, Gabriel Helmlinger.
Oncoimmunology, 2020 Sep 17; 9(1). PMID: 32934874    Free PMC article.
Review.
Current Clinical Evidence and Potential Solutions to Increase Benefit of CAR T-Cell Therapy for Patients with Solid Tumors.
Marion Alcantara, Pauline Du Rusquec, Emanuela Romano.
Oncoimmunology, 2020 Sep 17; 9(1). PMID: 32934880    Free PMC article.
Review.
Overcoming Resistance to Drugs Targeting KRAS Mutation.
Delong Jiao, Shengyu Yang.
Innovation (Camb), 2020 Sep 18; 1(2). PMID: 32939510    Free PMC article.
Layilin augments integrin activation to promote antitumor immunity.
Kelly M Mahuron, Joshua M Moreau, +18 authors, Michael D Rosenblum.
J Exp Med, 2020 Jun 17; 217(9). PMID: 32539073    Free PMC article.
Tissue-specific tumour microenvironments are an emerging determinant of immunotherapy responses.
Amanda J Oliver, Phillip K Darcy, Michael H Kershaw, Clare Y Slaney.
J Thorac Dis, 2020 Sep 19; 12(8). PMID: 32944364    Free PMC article.
Chimeric antigen receptor T cell therapies for thoracic cancers-challenges and opportunities.
Jack D Chan, Aaron J Harrison, +2 authors, Clare Y Slaney.
J Thorac Dis, 2020 Sep 19; 12(8). PMID: 32944365    Free PMC article.
Natural products and their derivatives: Promising modulators of tumor immunotherapy.
Li-Juan Deng, Ming Qi, +3 authors, Jia-Xu Chen.
J Leukoc Biol, 2020 Jul 18; 108(2). PMID: 32678943    Free PMC article.
Review.
Leukotrienes in Tumor-Associated Inflammation.
Wen Tian, Xinguo Jiang, +3 authors, Stanley G Rockson.
Front Pharmacol, 2020 Sep 26; 11. PMID: 32973519    Free PMC article.
Review.
Exploiting NK Cell Surveillance Pathways for Cancer Therapy.
Alexander David Barrow, Marco Colonna.
Cancers (Basel), 2019 Jan 11; 11(1). PMID: 30626155    Free PMC article.
Review.
CRISPR-Cas9 a boon or bane: the bumpy road ahead to cancer therapeutics.
Debarati Ghosh, Prabhadevi Venkataramani, Saikat Nandi, Sonali Bhattacharjee.
Cancer Cell Int, 2019 Jan 15; 19. PMID: 30636933    Free PMC article.
Highly Cited. Review.
Mechanisms of Primary and Secondary Resistance to Immune Checkpoint Inhibitors in Cancer.
Tiffany Seto, Danny Sam, Minggui Pan.
Med Sci (Basel), 2019 Jan 27; 7(2). PMID: 30678257    Free PMC article.
Review.
The Risks and Benefits of Immune Checkpoint Blockade in Anti-AChR Antibody-Seropositive Non-Small Cell Lung Cancer Patients.
Koichi Saruwatari, Ryo Sato, +8 authors, Takuro Sakagami.
Cancers (Basel), 2019 Jan 27; 11(2). PMID: 30682845    Free PMC article.
Multiscale Agent-Based and Hybrid Modeling of the Tumor Immune Microenvironment.
Kerri-Ann Norton, Chang Gong, Samira Jamalian, Aleksander S Popel.
Processes (Basel), 2019 Feb 01; 7(1). PMID: 30701168    Free PMC article.
Highly Cited.
Virus-Based Immunotherapy of Glioblastoma.
Miika Martikainen, Magnus Essand.
Cancers (Basel), 2019 Feb 16; 11(2). PMID: 30764570    Free PMC article.
Highly Cited. Review.
Beyond PD-1/PD-L1 Inhibition: What the Future Holds for Breast Cancer Immunotherapy.
Sebastian Chrétien, Ioannis Zerdes, +2 authors, Theodoros Foukakis.
Cancers (Basel), 2019 May 08; 11(5). PMID: 31060337    Free PMC article.
Review.
Contribution of Epithelial Plasticity to Therapy Resistance.
Patricia G Santamaría, Gema Moreno-Bueno, Amparo Cano.
J Clin Med, 2019 May 17; 8(5). PMID: 31091749    Free PMC article.
Highly Cited. Review.
Immunoprofiling of Breast Cancer Antigens Using Antibodies Derived from Local Lymph Nodes.
Anna Rachel Young, Jessica Da Gama Duarte, +7 authors, Els Meeusen.
Cancers (Basel), 2019 May 19; 11(5). PMID: 31100936    Free PMC article.
Monoclonal antibody therapy of solid tumors: clinical limitations and novel strategies to enhance treatment efficacy.
Esteban Cruz, Veysel Kayser.
Biologics, 2019 May 24; 13. PMID: 31118560    Free PMC article.
Highly Cited. Review.
Mistletoe and Immunomodulation: Insights and Implications for Anticancer Therapies.
Shiao Li Oei, Anja Thronicke, Friedemann Schad.
Evid Based Complement Alternat Med, 2019 May 24; 2019. PMID: 31118962    Free PMC article.
Review.
Cancer Immunotherapies and Humanized Mouse Drug Testing Platforms.
Qingfeng Chen, Jiaxu Wang, Wai Nam Liu, Yue Zhao.
Transl Oncol, 2019 May 24; 12(7). PMID: 31121491    Free PMC article.
Review.
Outcomes and Quality of Life of Systemic Therapy in Advanced Hepatocellular Carcinoma.
Kehua Zhou, Christos Fountzilas.
Cancers (Basel), 2019 Jun 27; 11(6). PMID: 31234316    Free PMC article.
Review.
Targeting Immune-Mediated Dormancy: A Promising Treatment of Cancer.
Hao-Fan Wang, Sha-Sha Wang, +3 authors, Ya-Ling Tang.
Front Oncol, 2019 Jul 13; 9. PMID: 31297335    Free PMC article.
Review.
AP-1 Transcription Factors as Regulators of Immune Responses in Cancer.
Vasileios Atsaves, Vasiliki Leventaki, George Z Rassidakis, Francois X Claret.
Cancers (Basel), 2019 Jul 26; 11(7). PMID: 31340499    Free PMC article.
Review.
Obesity and Breast Cancer: Role of Leptin.
Flora Sánchez-Jiménez, Antonio Pérez-Pérez, Luis de la Cruz-Merino, Víctor Sánchez-Margalet.
Front Oncol, 2019 Aug 06; 9. PMID: 31380268    Free PMC article.
Review.
Low Photosensitizer Dose and Early Radiotherapy Enhance Antitumor Immune Response of Photodynamic Therapy-Based Dendritic Cell Vaccination.
Bastien Doix, Natalia Trempolec, Olivier Riant, Olivier Feron.
Front Oncol, 2019 Sep 12; 9. PMID: 31508370    Free PMC article.
QSP-IO: A Quantitative Systems Pharmacology Toolbox for Mechanistic Multiscale Modeling for Immuno-Oncology Applications.
Richard J Sové, Mohammad Jafarnejad, +3 authors, Aleksander S Popel.
CPT Pharmacometrics Syst Pharmacol, 2020 Jul 04; 9(9). PMID: 32618119    Free PMC article.
Chemically Programmed Vaccines: Iron Catalysis in Nanoparticles Enhances Combination Immunotherapy and Immunotherapy-Promoted Tumor Ferroptosis.
Ane Ruiz-de-Angulo, Marc Bilbao-Asensio, +7 authors, Juan C Mareque-Rivas.
iScience, 2020 Sep 13; 23(9). PMID: 32919370    Free PMC article.
Treatment-related adverse events as surrogate to response rate to immune checkpoint blockade.
Yanyun Shen, Yunfeng Chen, Duoqin Wang, Zhidong Zhu.
Medicine (Baltimore), 2020 Sep 15; 99(37). PMID: 32925773    Free PMC article.
Systematic Review.
Upregulated expression of LncRNA nicotinamide nucleotide transhydrogenase antisense RNA 1 is correlated with unfavorable clinical outcomes in cancers.
Chenghao Zhang, Xiaolei Ren, Zhongyue Liu, Chao Tu.
BMC Cancer, 2020 Sep 16; 20(1). PMID: 32928135    Free PMC article.
Analyzing One Cell at a TIME: Analysis of Myeloid Cell Contributions in the Tumor Immune Microenvironment.
Vitaliy Davidov, Garrett Jensen, +2 authors, Ping-Ying Pan.
Front Immunol, 2020 Sep 29; 11. PMID: 32983100    Free PMC article.
Review.
Development of an Immune-Related Risk Signature for Predicting Prognosis in Lung Squamous Cell Carcinoma.
Denggang Fu, Biyu Zhang, +2 authors, Wang Xin.
Front Genet, 2020 Oct 03; 11. PMID: 33005178    Free PMC article.
Tumor-Infiltrating Lymphocytes and Their Prognostic Value in Cutaneous Melanoma.
Fabienne Maibach, Hassan Sadozai, +2 authors, Mirjam Schenk.
Front Immunol, 2020 Oct 06; 11. PMID: 33013886    Free PMC article.
Review.
PD-L1 on dendritic cells attenuates T cell activation and regulates response to immune checkpoint blockade.
Qi Peng, Xiangyan Qiu, +8 authors, Haidong Tang.
Nat Commun, 2020 Sep 26; 11(1). PMID: 32973173    Free PMC article.
Impact of anatomic site on antigen-presenting cells in cancer.
Maria Zagorulya, Ellen Duong, Stefani Spranger.
J Immunother Cancer, 2020 Oct 07; 8(2). PMID: 33020244    Free PMC article.
Review.
Tumor-associated carbohydrates and immunomodulatory lectins as targets for cancer immunotherapy.
Natalia Rodrigues Mantuano, Marina Natoli, Alfred Zippelius, Heinz Läubli.
J Immunother Cancer, 2020 Oct 07; 8(2). PMID: 33020245    Free PMC article.
Review.
Pneumonitis Induced by Immune Checkpoint Inhibitors: From Clinical Data to Translational Investigation.
Shicong Zhu, Yang Fu, +2 authors, Jun Wang.
Front Oncol, 2020 Oct 13; 10. PMID: 33042827    Free PMC article.
Review.
Immunological combination treatment holds the key to improving survival in pancreatic cancer.
M H Sodergren, N Mangal, +4 authors, N Habib.
J Cancer Res Clin Oncol, 2020 Aug 05; 146(11). PMID: 32748119    Free PMC article.
Review.
m6 A RNA methyltransferases METTL3/14 regulate immune responses to anti-PD-1 therapy.
Lingling Wang, Hui Hui, +5 authors, Tariq M Rana.
EMBO J, 2020 Sep 24; 39(20). PMID: 32964498    Free PMC article.
Analysis of the molecular nature associated with microsatellite status in colon cancer identifies clinical implications for immunotherapy.
Xuanwen Bao, Hangyu Zhang, +10 authors, Fanglong Liu.
J Immunother Cancer, 2020 Oct 09; 8(2). PMID: 33028695    Free PMC article.
A gene expression signature of TREM2hi macrophages and γδ T cells predicts immunotherapy response.
Donghai Xiong, Yian Wang, Ming You.
Nat Commun, 2020 Oct 10; 11(1). PMID: 33033253    Free PMC article.
Evolving impact of long-term survival results on metastatic melanoma treatment.
Olivier Michielin, Michael B Atkins, +2 authors, Paolo Antonio Ascierto.
J Immunother Cancer, 2020 Oct 11; 8(2). PMID: 33037115    Free PMC article.
Review.
Focal adhesion ribonucleoprotein complex proteins are major humoral cancer antigens and targets in autoimmune diseases.
Shinichiro Atsumi, Hiroto Katoh, +14 authors, Shumpei Ishikawa.
Commun Biol, 2020 Oct 18; 3(1). PMID: 33067514    Free PMC article.
Severe delayed pulmonary toxicity following PD-L1-specific CAR-T cell therapy for non-small cell lung cancer.
Heping Liu, Yuxiang Ma, +16 authors, Jianchuan Xia.
Clin Transl Immunology, 2020 Oct 20; 9(10). PMID: 33072320    Free PMC article.
Revisiting T Cell Tolerance as a Checkpoint Target for Cancer Immunotherapy.
Simone Nüssing, Joseph A Trapani, Ian A Parish.
Front Immunol, 2020 Oct 20; 11. PMID: 33072137    Free PMC article.
Review.
Uncoupling Therapeutic Efficacy from Immune-Related Adverse Events in Immune Checkpoint Blockade.
Weilei Hu, Guosheng Wang, +2 authors, Ming You.
iScience, 2020 Oct 22; 23(10). PMID: 33083746    Free PMC article.
Review.
Immunotherapy for Glioblastoma: Current State, Challenges, and Future Perspectives.
Minfeng Yang, In Young Oh, +2 authors, Jung Sun Yoo.
Cancers (Basel), 2020 Aug 23; 12(9). PMID: 32824974    Free PMC article.
Review.
A Tumor-Immune Interaction Model for Synergistic Combinations of Anti PD-L1 and Ionizing Irradiation Treatment.
Jong Hyuk Byun, In-Soo Yoon, +2 authors, Il Hyo Jung.
Pharmaceutics, 2020 Sep 04; 12(9). PMID: 32878065    Free PMC article.
Repurposing Immunomodulatory Therapies against Coronavirus Disease 2019 (COVID-19) in the Era of Cardiac Vigilance: A Systematic Review.
Courtney M Campbell, Avirup Guha, +2 authors, Daniel Addison.
J Clin Med, 2020 Sep 17; 9(9). PMID: 32932930    Free PMC article.
Review.
Breaking Bottlenecks for the TCR Therapy of Cancer.
Lena Gaissmaier, Mariam Elshiaty, Petros Christopoulos.
Cells, 2020 Sep 18; 9(9). PMID: 32937956    Free PMC article.
Review.
Irreversible electroporation plus allogenic Vγ9Vδ2 T cells enhances antitumor effect for locally advanced pancreatic cancer patients.
Mao Lin, Xiaoyan Zhang, +7 authors, Yong Jiang.
Signal Transduct Target Ther, 2020 Oct 24; 5(1). PMID: 33093457    Free PMC article.
Addition of Radiotherapy to Immunotherapy: Effects on Outcome of Different Subgroups Using a Propensity Score Matching.
Maike Trommer, Jaika Kinsky, +12 authors, Christian Baues.
Cancers (Basel), 2020 Sep 02; 12(9). PMID: 32867046    Free PMC article.
Cannabis Consumption Used by Cancer Patients during Immunotherapy Correlates with Poor Clinical Outcome.
Gil Bar-Sela, Idan Cohen, +10 authors, David Meiri.
Cancers (Basel), 2020 Sep 03; 12(9). PMID: 32872248    Free PMC article.
Targeting Myeloid-Derived Suppressor Cells in Cancer Immunotherapy.
Yufei Wang, Anna Jia, +5 authors, Guangwei Liu.
Cancers (Basel), 2020 Sep 19; 12(9). PMID: 32942545    Free PMC article.
Review.
Self-Adjuvanting Cancer Vaccines from Conjugation-Ready Lipid A Analogues and Synthetic Long Peptides.
Niels R M Reintjens, Elena Tondini, +8 authors, Jeroen D C Codée.
J Med Chem, 2020 Sep 23; 63(20). PMID: 32960056    Free PMC article.
iRGD Peptide as a Tumor-Penetrating Enhancer for Tumor-Targeted Drug Delivery.
Sujin Kang, Sooyeun Lee, Soyeun Park.
Polymers (Basel), 2020 Aug 28; 12(9). PMID: 32847045    Free PMC article.
Review.
Efficient Delivery and Replication of Oncolytic Virus for Successful Treatment of Head and Neck Cancer.
Masakazu Hamada, Yoshiaki Yura.
Int J Mol Sci, 2020 Oct 01; 21(19). PMID: 32992948    Free PMC article.
Review.
A novel format for recombinant antibody-interleukin-2 fusion proteins exhibits superior tumor-targeting properties in vivo.
Tiziano Ongaro, Baptiste Gouyou, +3 authors, Alessandra Villa.
Oncotarget, 2020 Oct 29; 11(41). PMID: 33110477    Free PMC article.
Partial Least-Squares Discriminant Analysis and Ensemble-Based Flexible Docking of PD-1/PD-L1 Inhibitors: A Pilot Study.
Zuyin Kuang, Yu Heng, +4 authors, Hu Mei.
ACS Omega, 2020 Oct 29; 5(41). PMID: 33111018    Free PMC article.
Exploration of Feasible Immune Biomarkers for Immune Checkpoint Inhibitors in Head and Neck Squamous Cell Carcinoma Treatment in Real World Clinical Practice.
Hui-Ching Wang, Tsung-Jang Yeh, +2 authors, Shih-Feng Cho.
Int J Mol Sci, 2020 Oct 21; 21(20). PMID: 33076306    Free PMC article.
Review.
Taming the Sentinels: Microbiome-Derived Metabolites and Polarization of T Cells.
Lukasz Wojciech, Kevin S W Tan, Nicholas R J Gascoigne.
Int J Mol Sci, 2020 Oct 23; 21(20). PMID: 33086747    Free PMC article.
Review.
Combination Immunotherapy Using Oncolytic Virus for the Treatment of Advanced Solid Tumors.
Chang-Myung Oh, Hong Jae Chon, Chan Kim.
Int J Mol Sci, 2020 Oct 23; 21(20). PMID: 33086754    Free PMC article.
Review.
Vestigial-like 1 is a shared targetable cancer-placenta antigen expressed by pancreatic and basal-like breast cancers.
Sherille D Bradley, Amjad H Talukder, +29 authors, Gregory Lizée.
Nat Commun, 2020 Oct 23; 11(1). PMID: 33087697    Free PMC article.
Evolving Paradigms in the Management and Outcomes of Sarcomatoid Renal Cell Carcinoma in the Era of Immune Checkpoint Inhibitors.
Ragia Aly, Amandeep S Aujla, +3 authors, Sheila Kalathil.
World J Oncol, 2020 Oct 30; 11(5). PMID: 33117461    Free PMC article.
Review.
Checkpoint therapeutic target database (CKTTD): the first comprehensive database for checkpoint targets and their modulators in cancer immunotherapy.
Yixiao Zhang, Yuan Yao, +15 authors, Yongliang Yang.
J Immunother Cancer, 2020 Oct 29; 8(2). PMID: 33109630    Free PMC article.
Endogenous HLA-DQ8αβ programs superantigens (SEG/SEI) to silence toxicity and unleash a tumoricidal network with long-term melanoma survival.
Peter Knopick, David Terman, +6 authors, David Bradley.
J Immunother Cancer, 2020 Oct 29; 8(2). PMID: 33109631    Free PMC article.
Arsenic trioxide (ATO) induced degradation of Cyclin D1 sensitized PD-1/PD-L1 checkpoint inhibitor in oral and esophageal squamous cell carcinoma.
Guanxia Zhu, Xia Li, +7 authors, Weimin Mao.
J Cancer, 2020 Oct 14; 11(22). PMID: 33046973    Free PMC article.
The Immunogenic Potential of Recurrent Cancer Drug Resistance Mutations: An In Silico Study.
Marco Punta, Victoria A Jennings, Alan A Melcher, Stefano Lise.
Front Immunol, 2020 Nov 03; 11. PMID: 33133066    Free PMC article.
Shp1 Loss Enhances Macrophage Effector Function and Promotes Anti-Tumor Immunity.
Darienne R Myers, Clare L Abram, +13 authors, Clifford A Lowell.
Front Immunol, 2020 Nov 03; 11. PMID: 33133093    Free PMC article.
Antihypoxic oxygenation agents with respiratory hyperoxia to improve cancer immunotherapy.
Stephen M Hatfield, Michail V Sitkovsky.
J Clin Invest, 2020 Sep 02; 130(11). PMID: 32870821    Free PMC article.
Review.
Selective SIRPα blockade reverses tumor T cell exclusion and overcomes cancer immunotherapy resistance.
Vanessa Gauttier, Sabrina Pengam, +40 authors, Nicolas Poirier.
J Clin Invest, 2020 Oct 20; 130(11). PMID: 33074246    Free PMC article.
Epigenetics in modulating immune functions of stromal and immune cells in the tumor microenvironment.
Xingyi Pan, Lei Zheng.
Cell Mol Immunol, 2020 Jul 24; 17(9). PMID: 32699350    Free PMC article.
Review.
Human macrophages engineered to secrete a bispecific T cell engager support antigen-dependent T cell responses to glioblastoma.
Jennifer L Gardell, Lisa R Matsumoto, +7 authors, Courtney A Crane.
J Immunother Cancer, 2020 Oct 31; 8(2). PMID: 33122397    Free PMC article.
Targeting TANK-binding kinase 1 (TBK1) in cancer.
Or-Yam Revach, Shuming Liu, Russell W Jenkins.
Expert Opin Ther Targets, 2020 Sep 24; 24(11). PMID: 32962465    Free PMC article.
Review.
Regulatory (FoxP3+) T cells and TGF-β predict the response to anti-PD-1 immunotherapy in patients with non-small cell lung cancer.
Jiae Koh, Joon Young Hur, +8 authors, Myung-Ju Ahn.
Sci Rep, 2020 Nov 06; 10(1). PMID: 33149213    Free PMC article.
Deciphering UV-induced DNA Damage Responses to Prevent and Treat Skin Cancer.
Jihoon W Lee, Kajan Ratnakumar, +2 authors, Masaoki Kawasumi.
Photochem Photobiol, 2020 Mar 03; 96(3). PMID: 32119110    Free PMC article.
Review.
[Chimeric antigen receptors in oncology: clinical applications and new developments].
Alexander Michels, Jessica Hartmann, Christian J Buchholz.
Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz, 2020 Oct 07; 63(11). PMID: 33021679    Free PMC article.
Review.
Mechanisms of hyperprogressive disease after immune checkpoint inhibitor therapy: what we (don't) know.
Simone Camelliti, Valentino Le Noci, +8 authors, Michele Sommariva.
J Exp Clin Cancer Res, 2020 Nov 11; 39(1). PMID: 33168050    Free PMC article.
Review.
Platelet PD-L1 suppresses anti-cancer immune cell activity in PD-L1 negative tumors.
Alexander B Zaslavsky, M P Adams, +18 authors, Ganesh S Palapattu.
Sci Rep, 2020 Nov 11; 10(1). PMID: 33168847    Free PMC article.
Immune Checkpoint Blockade Therapy for Hepatocellular Carcinoma: Clinical Challenges and Considerations.
Qi Zhang, Yiwen Chen, Xueli Bai, Tingbo Liang.
Front Oncol, 2020 Nov 13; 10. PMID: 33178615    Free PMC article.
Review.
Immune Checkpoints and CAR-T Cells: The Pioneers in Future Cancer Therapies?
Negar Hosseinkhani, Afshin Derakhshani, +9 authors, Behzad Baradaran.
Int J Mol Sci, 2020 Nov 11; 21(21). PMID: 33167514    Free PMC article.
Review.
Natural Killer T-Cell Agonist α-Galactosylceramide and PD-1 Blockade Synergize to Reduce Tumor Development in a Preclinical Model of Colon Cancer.
Ying Wang, Madhura S Bhave, Hideo Yagita, Susanna L Cardell.
Front Immunol, 2020 Nov 17; 11. PMID: 33193386    Free PMC article.
SOCS, Intrinsic Virulence Factors, and Treatment of COVID-19.
Howard M Johnson, Alfred S Lewin, Chulbul M Ahmed.
Front Immunol, 2020 Nov 17; 11. PMID: 33193390    Free PMC article.
Review.
The Pan-Omics Landscape of Renal Cell Carcinoma and Its Implication on Future Clinical Practice.
Jennifer J Huang, James J Hsieh.
Kidney Cancer, 2020 Nov 17; 4(3). PMID: 33195887    Free PMC article.
Review.
Osteonecrosis of the jaw induced by treatment with anti-PD-1 immunotherapy: a case report.
Xerxes Pundole, Amy Little Jones, +5 authors, Michael A Davies.
Immunotherapy, 2020 Sep 10; 12(17). PMID: 32900256    Free PMC article.
Efficacy of nivolumab and ipilimumab in patients with malignant pleural mesothelioma is related to a subtype of effector memory cytotoxic T cells: Translational evidence from two clinical trials.
Joanne M Mankor, Maria J Disselhorst, +3 authors, Heleen Vroman.
EBioMedicine, 2020 Nov 10; 62. PMID: 33166791    Free PMC article.
Targeting dual signalling pathways in concert with immune checkpoints for the treatment of pancreatic cancer.
Erik S Knudsen, Vishnu Kumarasamy, +11 authors, Agnieszka K Witkiewicz.
Gut, 2020 May 20; 70(1). PMID: 32424005    Free PMC article.
Human T Cells Expressing a CD19 CAR-T Receptor Provide Insights into Mechanisms of Human CD19-Positive β Cell Destruction.
Haiting Ma, Jacob F Jeppesen, Rudolf Jaenisch.
Cell Rep Med, 2020 Nov 19; 1(6). PMID: 33205073    Free PMC article.
CYP1B1 as a therapeutic target in cardio-oncology.
Alexa N Carrera, Marianne K O Grant, Beshay N Zordoky.
Clin Sci (Lond), 2020 Nov 14; 134(21). PMID: 33185690    Free PMC article.
A narrative review of toxicity of chemoradiation and immunotherapy for unresectable, locally advanced non-small cell lung cancer.
Rahul N Prasad, Terence M Williams.
Transl Lung Cancer Res, 2020 Nov 20; 9(5). PMID: 33209624    Free PMC article.
Review.
Pan-TGFβ inhibition by SAR439459 relieves immunosuppression and improves antitumor efficacy of PD-1 blockade.
Rita Greco, Hongjing Qu, +16 authors, Sharad Sharma.
Oncoimmunology, 2020 Nov 24; 9(1). PMID: 33224628    Free PMC article.
Clinical value of CTLA4 combined with clinicopathological factors in evaluating the prognosis of breast cancer.
Junyi Wu, Lei Li, +3 authors, Zhihai Peng.
Gland Surg, 2020 Nov 24; 9(5). PMID: 33224807    Free PMC article.
PD-1 and TIGIT coexpression identifies a circulating CD8 T cell subset predictive of response to anti-PD-1 therapy.
Sylvain Simon, Valentin Voillet, +21 authors, Nathalie Labarriere.
J Immunother Cancer, 2020 Nov 15; 8(2). PMID: 33188038    Free PMC article.
Development and validation of a prognostic and immunotherapeutically relevant model in hepatocellular carcinoma.
Yu Wang, Yanting Xie, +2 authors, Renyan Gong.
Ann Transl Med, 2020 Nov 27; 8(18). PMID: 33241026    Free PMC article.
Unveiling the Hidden Treasury: CIITA-Driven MHC Class II Expression in Tumor Cells to Dig up the Relevant Repertoire of Tumor Antigens for Optimal Stimulation of Tumor Specific CD4+ T Helper Cells.
Greta Forlani, Mariam Shallak, Fabrizio Celesti, Roberto S Accolla.
Cancers (Basel), 2020 Nov 04; 12(11). PMID: 33138029    Free PMC article.
Review.
Spontaneous Regression of Advanced Hepatocellular Carcinoma.
Dhiraj J Sonbare, Rupal Bandi, +2 authors, Obaid S Shaikh.
Case Rep Gastroenterol, 2020 Dec 01; 14(3). PMID: 33250687    Free PMC article.
Augmenting Anticancer Immunity Through Combined Targeting of Angiogenic and PD-1/PD-L1 Pathways: Challenges and Opportunities.
Stephen P Hack, Andrew X Zhu, Yulei Wang.
Front Immunol, 2020 Dec 01; 11. PMID: 33250900    Free PMC article.
Review.
H19X-encoded miR-424(322)/-503 cluster: emerging roles in cell differentiation, proliferation, plasticity and metabolism.
Fan Wang, Rui Liang, +6 authors, Yu Liu.
Cell Mol Life Sci, 2018 Nov 27; 76(5). PMID: 30474694    Free PMC article.
Review.
Bioactive Nanoparticles for Cancer Immunotherapy.
Suchithra Poilil Surendran, Myeong Ju Moon, Rayoung Park, Yong Yeon Jeong.
Int J Mol Sci, 2018 Dec 07; 19(12). PMID: 30518139    Free PMC article.
Review.
Targeting Multiple Receptors to Increase Checkpoint Blockade Efficacy.
David J Zahavi, Louis M Weiner.
Int J Mol Sci, 2019 Jan 10; 20(1). PMID: 30621125    Free PMC article.
Review.
SA-49, a novel aloperine derivative, induces MITF-dependent lysosomal degradation of PD-L1.
Na Zhang, Yueying Dou, +8 authors, Danqing Song.
EBioMedicine, 2019 Feb 04; 40. PMID: 30711516    Free PMC article.
The growing role of precision and personalized medicine for cancer treatment.
Paulina Krzyszczyk, Alison Acevedo, +13 authors, Martin L Yarmush.
Technology (Singap World Sci), 2019 Feb 05; 6(3-4). PMID: 30713991    Free PMC article.
Innate Immune Modulation by GM-CSF and IL-3 in Health and Disease.
Francesco Borriello, Maria Rosaria Galdiero, +3 authors, Gianni Marone.
Int J Mol Sci, 2019 Feb 17; 20(4). PMID: 30769926    Free PMC article.
Review.
3D models in the new era of immune oncology: focus on T cells, CAF and ECM.
Francesca Di Modugno, Cristina Colosi, +3 authors, Paola Nisticò.
J Exp Clin Cancer Res, 2019 Mar 23; 38(1). PMID: 30898166    Free PMC article.
Review.
Targeted immunotherapy with a checkpoint inhibitor in combination with chemotherapy: A new clinical paradigm in the treatment of triple-negative breast cancer.
Farhan S Cyprian, Saghir Akhtar, Zoran Gatalica, Semir Vranic.
Bosn J Basic Med Sci, 2019 Mar 28; 19(3). PMID: 30915922    Free PMC article.
Highly Cited. Review.
Molecular Interactions of Antibody Drugs Targeting PD-1, PD-L1, and CTLA-4 in Immuno-Oncology.
Hyun Tae Lee, Sang Hyung Lee, Yong-Seok Heo.
Molecules, 2019 Mar 29; 24(6). PMID: 30917623    Free PMC article.
Review.
In vitro assessment of PD-L1+ microvesicles in the cyst fluid of non-syndromic odontogenic keratocysts.
Qi-Wen Man, Wen-Qun Zhong, +2 authors, Yi Zhao.
J Mol Histol, 2019 May 23; 50(4). PMID: 31115840
Remarkable Alteration of PD-L1 Expression after Immune Checkpoint Therapy in Patients with Non-Small-Cell Lung Cancer: Two Autopsy Case Reports.
Toshiaki Takahashi, Akiko Tateishi, Andrey Bychkov, Junya Fukuoka.
Int J Mol Sci, 2019 May 28; 20(10). PMID: 31130676    Free PMC article.
Immunomodulatory and immunotherapeutic implications of tobacco smoking in squamous cell carcinomas and normal airway epithelium.
Jingming Wang, Maximilian Linxweiler, +2 authors, Luc G T Morris.
Oncotarget, 2019 Jun 25; 10(39). PMID: 31231463    Free PMC article.
Cutaneous Metastasis after Surgery, Injury, Lymphadenopathy, and Peritonitis: Possible Mechanisms.
Isao Otsuka.
Int J Mol Sci, 2019 Jul 07; 20(13). PMID: 31277406    Free PMC article.
Review.
New Insights into Mechanisms of Cisplatin Resistance: From Tumor Cell to Microenvironment.
Shang-Hung Chen, Jang-Yang Chang.
Int J Mol Sci, 2019 Aug 28; 20(17). PMID: 31450627    Free PMC article.
Review.
Can Allosteric Receptor-Protein Interactions in Receptor Complexes Be a Molecular Mechanism Involved in Cancer Immune Therapy?
Dasiel O Borroto-Escuela, Kjell Fuxe.
Front Endocrinol (Lausanne), 2019 Sep 05; 10. PMID: 31481934    Free PMC article.
MDSC subtypes and CD39 expression on CD8+ T cells predict the efficacy of anti-PD-1 immunotherapy in patients with advanced NSCLC.
Jiae Koh, Youjin Kim, +12 authors, Myung-Ju Ahn.
Eur J Immunol, 2020 Jun 09; 50(11). PMID: 32510574    Free PMC article.
Whole-genome sequencing identifies responders to Pembrolizumab in relapse/refractory natural-killer/T cell lymphoma.
Jing Quan Lim, Dachuan Huang, +38 authors, Soon Thye Lim.
Leukemia, 2020 Aug 06; 34(12). PMID: 32753688    Free PMC article.
CNOT4 enhances the efficacy of anti-PD-1 immunotherapy in a model of non-small cell lung cancer.
Biao Zhang, Song Han, Haitao Ma, Shaomu Chen.
FEBS Open Bio, 2020 Oct 10; 10(12). PMID: 33034149    Free PMC article.
Inhibition of the CCL2 receptor, CCR2, enhances tumor response to immune checkpoint therapy.
Megan M Tu, Hany A Abdel-Hafiz, +10 authors, Dan Theodorescu.
Commun Biol, 2020 Nov 29; 3(1). PMID: 33247183    Free PMC article.
Emerging impact of the long noncoding RNA MIR22HG on proliferation and apoptosis in multiple human cancers.
Le Zhang, Cuixia Li, Xiulan Su.
J Exp Clin Cancer Res, 2020 Dec 04; 39(1). PMID: 33267888    Free PMC article.
Review.
Clinicopathological associations and prognostic values of IDH1 gene mutation, MGMT gene promoter methylation, and PD-L1 expressions in high-grade glioma treated with standard treatment.
Julius July, Diana Patricia, +10 authors, Michael Lumintang Loe.
Pan Afr Med J, 2020 Dec 08; 36. PMID: 33282092    Free PMC article.
Cancer Vaccines: Toward the Next Breakthrough in Cancer Immunotherapy.
Yuka Igarashi, Tetsuro Sasada.
J Immunol Res, 2020 Dec 08; 2020. PMID: 33282961    Free PMC article.
Review.
Emerging nanomedicines for effective breast cancer immunotherapy.
Amirhossein Bahreyni, Yasir Mohamud, Honglin Luo.
J Nanobiotechnology, 2020 Dec 11; 18(1). PMID: 33298099    Free PMC article.
Review.
Immune-focused multi-omics analysis of prostate cancer: leukocyte Ig-Like receptors are associated with disease progression.
Benjamin Vittrant, Alain Bergeron, +10 authors, Arnaud Droit.
Oncoimmunology, 2020 Dec 11; 9(1). PMID: 33299664    Free PMC article.
Cell and tissue engineering in lymph nodes for cancer immunotherapy.
Alexander J Najibi, David J Mooney.
Adv Drug Deliv Rev, 2020 Aug 05; 161-162. PMID: 32750376    Free PMC article.
Systematic Review.
Identifying and Targeting Human Tumor Antigens for T Cell-Based Immunotherapy of Solid Tumors.
Vid Leko, Steven A Rosenberg.
Cancer Cell, 2020 Aug 22; 38(4). PMID: 32822573    Free PMC article.
Review.
PD-L1 expression in liver metastasis: its clinical significance and discordance with primary tumor in colorectal cancer.
Xiao-Li Wei, Xuan Luo, +5 authors, Rui-Hua Xu.
J Transl Med, 2020 Dec 15; 18(1). PMID: 33308232    Free PMC article.
The Molecular and Microenvironmental Landscape of Glioblastomas: Implications for the Novel Treatment Choices.
Federica Di Cintio, Michele Dal Bo, +3 authors, Giuseppe Toffoli.
Front Neurosci, 2020 Dec 17; 14. PMID: 33324155    Free PMC article.
Review.
PD-L1-Mediated Immunosuppression in Glioblastoma Is Associated With the Infiltration and M2-Polarization of Tumor-Associated Macrophages.
Zhiyuan Zhu, Hongbo Zhang, +4 authors, Mengqi Gao.
Front Immunol, 2020 Dec 18; 11. PMID: 33329573    Free PMC article.
Applications of Single-Cell Omics to Dissect Tumor Microenvironment.
Tingting Guo, Weimin Li, Xuyu Cai.
Front Genet, 2020 Dec 18; 11. PMID: 33329692    Free PMC article.
Review.
Modelling of Immune Checkpoint Network Explains Synergistic Effects of Combined Immune Checkpoint Inhibitor Therapy and the Impact of Cytokines in Patient Response.
Maria Kondratova, Emmanuel Barillot, Andrei Zinovyev, Laurence Calzone.
Cancers (Basel), 2020 Dec 06; 12(12). PMID: 33276543    Free PMC article.
TGF-β Mediated Immune Evasion in Cancer-Spotlight on Cancer-Associated Fibroblasts.
Parisa Ghahremanifard, Ayan Chanda, Shirin Bonni, Pinaki Bose.
Cancers (Basel), 2020 Dec 10; 12(12). PMID: 33291370    Free PMC article.
Cancer Immunotherapy and Application of Nanoparticles in Cancers Immunotherapy as the Delivery of Immunotherapeutic Agents and as the Immunomodulators.
Tilahun Ayane Debele, Cheng-Fa Yeh, Wen-Pin Su.
Cancers (Basel), 2020 Dec 19; 12(12). PMID: 33333816    Free PMC article.
Review.
Berberine diminishes cancer cell PD-L1 expression and facilitates antitumor immunity via inhibiting the deubiquitination activity of CSN5.
Yang Liu, Xiaojia Liu, +7 authors, Hongbin Deng.
Acta Pharm Sin B, 2020 Dec 24; 10(12). PMID: 33354502    Free PMC article.
Current Immunotherapy Approaches in Non-Hodgkin Lymphomas.
Robert Pytlik, Kamila Polgarova, Jana Karolova, Pavel Klener.
Vaccines (Basel), 2020 Dec 03; 8(4). PMID: 33260966    Free PMC article.
Review.
4-1BB co-stimulation further enhances anti-PD-1-mediated reinvigoration of exhausted CD39+ CD8 T cells from primary and metastatic sites of epithelial ovarian cancers.
Galam Leem, Junsik Park, +12 authors, Su-Hyung Park.
J Immunother Cancer, 2020 Dec 19; 8(2). PMID: 33335029    Free PMC article.
3D Tumor Models and Their Use for the Testing of Immunotherapies.
Nicolas Boucherit, Laurent Gorvel, Daniel Olive.
Front Immunol, 2020 Dec 29; 11. PMID: 33362787    Free PMC article.
Review.
Translational pathology, genomics and the development of systemic therapies for acral melanoma.
Yian Ann Chen, Jamie K Teer, +5 authors, Keiran S M Smalley.
Semin Cancer Biol, 2019 Nov 07; 61. PMID: 31689494    Free PMC article.
Review.
The Anticancer Potential of T Cell Receptor-Engineered T Cells.
Matyas Ecsedi, Megan S McAfee, Aude G Chapuis.
Trends Cancer, 2020 Sep 30; 7(1). PMID: 32988787    Free PMC article.
Review.
Infliximab Was Found to Be Effective for Treating Immunosuppressive Drug-resistant Hepatitis due to Durvalumab.
Koki Nakashima, Yoshiki Demura, +5 authors, Tamotsu Ishizuka.
Intern Med, 2020 Jul 31; 59(23). PMID: 32727989    Free PMC article.
An Activity-Guided Map of Electrophile-Cysteine Interactions in Primary Human T Cells.
Ekaterina V Vinogradova, Xiaoyu Zhang, +25 authors, Benjamin F Cravatt.
Cell, 2020 Jul 31; 182(4). PMID: 32730809    Free PMC article.
PET imaging facilitates antibody screening for synergistic radioimmunotherapy with a 177Lu-labeled αPD-L1 antibody.
Jingyun Ren, Mengxin Xu, +5 authors, Zhibo Liu.
Theranostics, 2021 Jan 05; 11(1). PMID: 33391476    Free PMC article.
Noninvasive Imaging of Cancer Immunotherapy.
Omar Abousaway, Taha Rakhshandehroo, +2 authors, Mohammad Rashidian.
Nanotheranostics, 2021 Jan 05; 5(1). PMID: 33391977    Free PMC article.
Review.
Liver metastasis restrains immunotherapy efficacy via macrophage-mediated T cell elimination.
Jiali Yu, Michael D Green, +37 authors, Weiping Zou.
Nat Med, 2021 Jan 06; 27(1). PMID: 33398162    Free PMC article.
Epigenetic modulation of immunotherapy and implications in head and neck cancer.
Liye Zhou, Na Xu, +2 authors, Ravindra Uppaluri.
Cancer Metastasis Rev, 2021 Jan 07; 40(1). PMID: 33403469    Free PMC article.
Review.
The immunology of renal cell carcinoma.
C Marcela Díaz-Montero, Brian I Rini, James H Finke.
Nat Rev Nephrol, 2020 Aug 01; 16(12). PMID: 32733094
Review.
Cell Adhesion Molecules in Plasticity and Metastasis.
Jessica A Smart, Julia E Oleksak, Edward J Hartsough.
Mol Cancer Res, 2020 Oct 03; 19(1). PMID: 33004622    Free PMC article.
Review.
Thrombin-PAR1 signaling in pancreatic cancer promotes an immunosuppressive microenvironment.
Patrick G Schweickert, Yi Yang, +8 authors, Stephen F Konieczny.
J Thromb Haemost, 2020 Oct 17; 19(1). PMID: 33064371    Free PMC article.
The Role of Antigen Processing and Presentation in Cancer and the Efficacy of Immune Checkpoint Inhibitor Immunotherapy.
Anastasia Mpakali, Efstratios Stratikos.
Cancers (Basel), 2021 Jan 08; 13(1). PMID: 33406696    Free PMC article.
Review.
Acquired Resistance to PD-1/PD-L1 Blockade in Lung Cancer: Mechanisms and Patterns of Failure.
Ranjan Pathak, Rebecca R Pharaon, +3 authors, Erminia Massarelli.
Cancers (Basel), 2021 Jan 10; 12(12). PMID: 33419311    Free PMC article.
Review.
Decoding the PTM-switchboard of Notch.
Daniel Antfolk, Christian Antila, +2 authors, Cecilia Sahlgren.
Biochim Biophys Acta Mol Cell Res, 2019 Jul 14; 1866(12). PMID: 31301363    Free PMC article.
Review.
Baseline immunity and impact of chemotherapy on immune microenvironment in cervical cancer.
Yi Zhang, Minhua Yu, +14 authors, Wen Di.
Br J Cancer, 2020 Oct 23; 124(2). PMID: 33087896    Free PMC article.
EULAR points to consider for the diagnosis and management of rheumatic immune-related adverse events due to cancer immunotherapy with checkpoint inhibitors.
Marie Kostine, Axel Finckh, +20 authors, Thierry Schaeverbeke.
Ann Rheum Dis, 2020 Apr 25; 80(1). PMID: 32327425    Free PMC article.
Skin immunization for effective treatment of multifocal melanoma refractory to PD1 blockade and Braf inhibitors.
Xingxing Hao, Louis D Falo Iii, +5 authors, Zhaoyang You.
J Immunother Cancer, 2021 Jan 08; 9(1). PMID: 33408093    Free PMC article.
Using nanoparticles for in situ vaccination against cancer: mechanisms and immunotherapy benefits.
Michael-Joseph Gorbet, Akansha Singh, +2 authors, Ashish Ranjan.
Int J Hyperthermia, 2021 Jan 12; 37(3). PMID: 33426995    Free PMC article.
Pivotal role of long non-coding ribonucleic acid-X-inactive specific transcript in regulating immune checkpoint programmed death ligand 1 through a shared pathway between miR-194-5p and miR-155-5p in hepatocellular carcinoma.
Sara M Atwa, Heba Handoussa, +2 authors, Hend M El Tayebi.
World J Hepatol, 2021 Jan 15; 12(12). PMID: 33442449    Free PMC article.
Immunodynamics of explanted human tumors for immuno-oncology.
Agathe Dubuisson, Jean-Eudes Fahrner, +43 authors, Laurence Zitvogel.
EMBO Mol Med, 2020 Dec 30; 13(1). PMID: 33372722    Free PMC article.
Damage-associated molecular pattern (DAMP) activation in melanoma: investigation of the immunogenic activity of 15-deoxy, Δ12,14 prostamide J2.
Ahmed Elhassanny, Rene Escobedo, +2 authors, Rukiyah Van Dross.
Oncotarget, 2021 Jan 16; 11(52). PMID: 33447347    Free PMC article.
Impact of immune checkpoint gene CD155 Ala67Thr and CD226 Gly307Ser polymorphisms on small cell lung cancer clinical outcome.
Jang Hyuck Lee, Seung Soo Yoo, +16 authors, Jae Yong Park.
Sci Rep, 2021 Jan 21; 11(1). PMID: 33469055    Free PMC article.
Single-cell RNA sequencing reveals heterogeneous tumor and immune cell populations in early-stage lung adenocarcinomas harboring EGFR mutations.
Di He, Di Wang, +5 authors, Guoping Fan.
Oncogene, 2020 Nov 05; 40(2). PMID: 33144684    Free PMC article.
TIME Is a Great Healer-Targeting Myeloid Cells in the Tumor Immune Microenvironment to Improve Triple-Negative Breast Cancer Outcomes.
Swarnima Singh, Xiang H F Zhang, Jeffrey M Rosen.
Cells, 2020 Dec 31; 10(1). PMID: 33374595    Free PMC article.
Review.
Clinical impact of COVID-19 on patients with cancer treated with immune checkpoint inhibition.
Aljosja Rogiers, Ines Pires da Silva, +46 authors, Georgina V Long.
J Immunother Cancer, 2021 Jan 21; 9(1). PMID: 33468556    Free PMC article.
Immunotherapy response modeling by ex-vivo organ culture for lung cancer.
Iris Kamer, Elizabeta Bab-Dinitz, +8 authors, Jair Bar.
Cancer Immunol Immunother, 2021 Jan 24; 70(8). PMID: 33484295
Mechanisms underlying low-clinical responses to PD-1/PD-L1 blocking antibodies in immunotherapy of cancer: a key role of exosomal PD-L1.
Zi Yin, Min Yu, +5 authors, Sheng Chen.
J Immunother Cancer, 2021 Jan 22; 9(1). PMID: 33472857    Free PMC article.
Review.
Current and future aspects of TIM-3 as biomarker or as potential targeted in non-small cell lung cancer scope: is there a role in clinical practice?
Ramon Andrade De Mello, Jin-Hui Zhu, +8 authors, Georgio Antoniou.
Transl Lung Cancer Res, 2021 Jan 26; 9(6). PMID: 33489794    Free PMC article.
Current and future immunotherapy approaches in ovarian cancer.
Nazım Can Demircan, Stergios Boussios, Tolga Tasci, Mehmet Akif Öztürk.
Ann Transl Med, 2021 Jan 26; 8(24). PMID: 33490226    Free PMC article.
Review.
Hydroxychloroquine can impair tumor response to anti-PD1 in subcutaneous mouse models.
Simon Wabitsch, John C McVey, +6 authors, Tim F Greten.
iScience, 2021 Jan 26; 24(1). PMID: 33490900    Free PMC article.
Multimodel preclinical platform predicts clinical response of melanoma to immunotherapy.
Eva Pérez-Guijarro, Howard H Yang, +22 authors, Glenn Merlino.
Nat Med, 2020 Apr 15; 26(5). PMID: 32284588    Free PMC article.
Polyvinyl Alcohol Carbazate as a Polymer-Based Antitumoral Agent.
Felix Sellberg, Robin Fröbom, +2 authors, David Berglund.
Front Oncol, 2021 Jan 29; 10. PMID: 33505913    Free PMC article.
Allogeneic Vγ9Vδ2 T-cell immunotherapy exhibits promising clinical safety and prolongs the survival of patients with late-stage lung or liver cancer.
Yan Xu, Zheng Xiang, +24 authors, Zhinan Yin.
Cell Mol Immunol, 2020 Sep 18; 18(2). PMID: 32939032    Free PMC article.
Preclinical PET imaging with the novel human antibody 89Zr-DFO-REGN3504 sensitively detects PD-L1 expression in tumors and normal tissues.
Marcus P Kelly, Sosina Makonnen, +12 authors, Jessica R Kirshner.
J Immunother Cancer, 2021 Jan 24; 9(1). PMID: 33483343    Free PMC article.
Unlocking the Mystery of the Therapeutic Effects of Chinese Medicine on Cancer.
Shao-Hsiang Liu, Po-Sheng Chen, +5 authors, Alan Yueh-Luen Lee.
Front Pharmacol, 2021 Feb 02; 11. PMID: 33519464    Free PMC article.
Midkine rewires the melanoma microenvironment toward a tolerogenic and immune-resistant state.
Daniela Cerezo-Wallis, Marta Contreras-Alcalde, +22 authors, María S Soengas.
Nat Med, 2020 Oct 21; 26(12). PMID: 33077955
Activity of murine surrogate antibodies for durvalumab and tremelimumab lacking effector function and the ability to deplete regulatory T cells in mouse models of cancer.
Darren J Schofield, Jennifer Percival-Alwyn, +18 authors, Michael Oberst.
MAbs, 2021 Jan 06; 13(1). PMID: 33397194    Free PMC article.
Normalization of electroretinogram and symptom resolution of melanoma-associated retinopathy with negative autoantibodies after treatment with programmed death-1 (PD-1) inhibitors for metastatic melanoma.
Karam Khaddour, Sangeeta Khanna, +4 authors, George Ansstas.
Cancer Immunol Immunother, 2021 Feb 06; 70(9). PMID: 33544215    Free PMC article.
MS4A1 expression and function in T cells in the colorectal cancer tumor microenvironment.
T William Mudd, Chunwan Lu, John D Klement, Kebin Liu.
Cell Immunol, 2020 Dec 23; 360. PMID: 33352466    Free PMC article.
The Role of Tumor Associated Macrophages in Hepatocellular Carcinoma.
Yu Huang, Wenhao Ge, +3 authors, Weilin Wang.
J Cancer, 2021 Feb 04; 12(5). PMID: 33531974    Free PMC article.
Review.
Immuno-Metabolism: The Role of Cancer Niche in Immune Checkpoint Inhibitor Resistance.
Chao-Yuan Weng, Cheng-Xiang Kao, Te-Sheng Chang, Yen-Hua Huang.
Int J Mol Sci, 2021 Jan 31; 22(3). PMID: 33514004    Free PMC article.
Review.
Targeting the HIF2-VEGF axis in renal cell carcinoma.
Toni K Choueiri, William G Kaelin.
Nat Med, 2020 Oct 07; 26(10). PMID: 33020645
Review.
Genome editing of immune cells using CRISPR/Cas9.
Segi Kim, Cedric Hupperetz, Seongjoon Lim, Chan Hyuk Kim.
BMB Rep, 2020 Dec 11; 54(1). PMID: 33298251    Free PMC article.
Review.
Immune receptor inhibition through enforced phosphatase recruitment.
Ricardo A Fernandes, Leon Su, +16 authors, K Christopher Garcia.
Nature, 2020 Oct 23; 586(7831). PMID: 33087934    Free PMC article.
A dual-modal PET/near infrared fluorescent nanotag for long-term immune cell tracking.
Stefan Harmsen, Emin Ilker Medine, +9 authors, Omer Aras.
Biomaterials, 2021 Jan 05; 269. PMID: 33395580    Free PMC article.
Surgery after neoadjuvant immunotherapy in patients with resectable non-small cell lung cancer.
Caroline Huynh, Logan A Walsh, Jonathan D Spicer.
Transl Lung Cancer Res, 2021 Feb 12; 10(1). PMID: 33569337    Free PMC article.
Review.
Neoadjuvant immunotherapy for elderly patients with non-small-cell lung cancer: a case report and literature review.
Jianqiang Li, Youhua Jiang, Jiangfeng Wang.
Ann Transl Med, 2021 Feb 12; 9(2). PMID: 33569484    Free PMC article.
Single-cell RNA-sequencing analyses identify heterogeneity of CD8+ T cell subpopulations and novel therapy targets in melanoma.
Weiwei Deng, Yubo Ma, +9 authors, Ruoyu Li.
Mol Ther Oncolytics, 2021 Feb 13; 20. PMID: 33575475    Free PMC article.
Considerations when treating high-grade pediatric glioma patients with immunotherapy.
Erin Crotty, Kira Downey, +6 authors, Hideho Okada.
Expert Rev Neurother, 2020 Nov 24; 21(2). PMID: 33225764    Free PMC article.
Lysophosphatidic Acid Is an Inflammatory Lipid Exploited by Cancers for Immune Evasion via Mechanisms Similar and Distinct From CTLA-4 and PD-1.
Divij Mathew, Raul M Torres.
Front Immunol, 2021 Feb 16; 11. PMID: 33584637    Free PMC article.
Review.
Full Spectrum Flow Cytometry as a Powerful Technology for Cancer Immunotherapy Research.
Diana L Bonilla, Gil Reinin, Edmond Chua.
Front Mol Biosci, 2021 Feb 16; 7. PMID: 33585561    Free PMC article.
Review.
Engineering advanced logic and distributed computing in human CAR immune cells.
Jang Hwan Cho, Atsushi Okuma, +3 authors, Wilson W Wong.
Nat Commun, 2021 Feb 06; 12(1). PMID: 33542232    Free PMC article.
Tumor Burden and Immunotherapy: Impact on Immune Infiltration and Therapeutic Outcomes.
Samuel I Kim, Christopher R Cassella, Katelyn T Byrne.
Front Immunol, 2021 Feb 19; 11. PMID: 33597954    Free PMC article.
Review.
Ex vivo modelling of PD-1/PD-L1 immune checkpoint blockade under acute, chronic, and exhaustion-like conditions of T-cell stimulation.
Alexander Roberts, Lindsay Bentley, +24 authors, Nicholas M Barnes.
Sci Rep, 2021 Feb 19; 11(1). PMID: 33597595    Free PMC article.
Targeting tumor-associated macrophages to synergize tumor immunotherapy.
Xiaonan Xiang, Jianguo Wang, Di Lu, Xiao Xu.
Signal Transduct Target Ther, 2021 Feb 24; 6(1). PMID: 33619259    Free PMC article.
Review.
Checkpoint inhibition through small molecule-induced internalization of programmed death-ligand 1.
Jang-June Park, Emily P Thi, +20 authors, Chris B Moore.
Nat Commun, 2021 Feb 24; 12(1). PMID: 33619272    Free PMC article.
Inhibition of Colony-Stimulating Factor-1 Receptor Enhances the Efficacy of Radiotherapy and Reduces Immune Suppression in Glioblastoma.
Muayad F Almahariq, Thomas J Quinn, +3 authors, Prakash Chinnaiyan.
In Vivo, 2021 Jan 07; 35(1). PMID: 33402457    Free PMC article.
Chromatin accessibility of circulating CD8+ T cells predicts treatment response to PD-1 blockade in patients with gastric cancer.
Hyun Mu Shin, Gwanghun Kim, +10 authors, Hang-Rae Kim.
Nat Commun, 2021 Feb 14; 12(1). PMID: 33579944    Free PMC article.
Developing an enhanced 7-color multiplex IHC protocol to dissect immune infiltration in human cancers.
Zhaoyu Sun, Richard Nyberg, +2 authors, William L Redmond.
PLoS One, 2021 Feb 18; 16(2). PMID: 33596250    Free PMC article.
Deregulated Immune Pathway Associated with Palbociclib Resistance in Preclinical Breast Cancer Models: Integrative Genomics and Transcriptomics.
Kamal Pandey, Eunbyeol Lee, +9 authors, Yong Wha Moon.
Genes (Basel), 2021 Jan 29; 12(2). PMID: 33504001    Free PMC article.
PD-L1 and B7-1 Cis-Interaction: New Mechanisms in Immune Checkpoints and Immunotherapies.
Christopher D Nishimura, Marc C Pulanco, +2 authors, Xingxing Zang.
Trends Mol Med, 2020 Nov 18; 27(3). PMID: 33199209    Free PMC article.
Review.
The Immunology of Syncytialized Trophoblast.
Danny J Schust, Elizabeth A Bonney, +4 authors, Jie Zhou.
Int J Mol Sci, 2021 Feb 14; 22(4). PMID: 33578919    Free PMC article.
Review.
Colony-stimulating factor 3 signaling in colon and rectal cancers: Immune response and CMS classification in TCGA data.
Apryl S Saunders, Dawn E Bender, +2 authors, Katherine T Morris.
PLoS One, 2021 Feb 20; 16(2). PMID: 33606788    Free PMC article.
Non-canonical PD-1 signaling in cancer and its potential implications in clinic.
Haoran Zha, Ying Jiang, +10 authors, Zhaoxia Li.
J Immunother Cancer, 2021 Feb 18; 9(2). PMID: 33593825    Free PMC article.
Review.
Immune checkpoint inhibitor-associated myocarditis: manifestations and mechanisms.
Javid Moslehi, Andrew H Lichtman, +2 authors, Richard N Kitsis.
J Clin Invest, 2021 Mar 02; 131(5). PMID: 33645548    Free PMC article.
Review.
Virus-specific memory T cell responses unmasked by immune checkpoint blockade cause hepatitis.
James A Hutchinson, Katharina Kronenberg, +21 authors, Sebastian Haferkamp.
Nat Commun, 2021 Mar 06; 12(1). PMID: 33664251    Free PMC article.
Immune Infiltration Landscape in Clear Cell Renal Cell Carcinoma Implications.
Yongfeng Wang, Ci Yin, Lele Geng, Weiyang Cai.
Front Oncol, 2021 Mar 06; 10. PMID: 33665156    Free PMC article.
An Investigator-Initiated Phase 2 Study of Nivolumab Plus Low-Dose Ipilimumab as First-Line Therapy for Microsatellite Instability-High Advanced Gastric or Esophagogastric Junction Cancer (NO LIMIT, WJOG13320G/CA209-7W7).
Hisato Kawakami, Shuichi Hironaka, +12 authors, Kei Muro.
Cancers (Basel), 2021 Mar 07; 13(4). PMID: 33671871    Free PMC article.
Ketogenic diet and ketone bodies enhance the anticancer effects of PD-1 blockade.
Gladys Ferrere, Maryam Tidjani Alou, +25 authors, Laurence Zitvogel.
JCI Insight, 2020 Dec 16; 6(2). PMID: 33320838    Free PMC article.
Trials and tribulations of pancreatic cancer immunotherapy.
Daniel R Principe, Murray Korc, +2 authors, Ajay Rana.
Cancer Lett, 2021 Feb 08; 504. PMID: 33549709    Free PMC article.
Review.
Activation of NF-κB and p300/CBP potentiates cancer chemoimmunotherapy through induction of MHC-I antigen presentation.
Yixuan Zhou, Ingmar Niels Bastian, +30 authors, Shabnam Shalapour.
Proc Natl Acad Sci U S A, 2021 Feb 20; 118(8). PMID: 33602823    Free PMC article.
Immune Regulation of the cGAS-STING Signaling Pathway in the Tumor Microenvironment and Its Clinical Application.
Feifei Pu, Fengxia Chen, +2 authors, Zengwu Shao.
Onco Targets Ther, 2021 Mar 11; 14. PMID: 33688199    Free PMC article.
Review.
New Insights Into the Cancer-Microbiome-Immune Axis: Decrypting a Decade of Discoveries.
Tejeshwar Jain, Prateek Sharma, +2 authors, Vikas Dudeja.
Front Immunol, 2021 Mar 13; 12. PMID: 33708214    Free PMC article.
Review.
CXCL9-expressing tumor-associated macrophages: new players in the fight against cancer.
Paola Marie Marcovecchio, Graham Thomas, Shahram Salek-Ardakani.
J Immunother Cancer, 2021 Feb 28; 9(2). PMID: 33637602    Free PMC article.
Review.
Polymeric Micelles in Cancer Immunotherapy.
Zhuoya Wan, Ruohui Zheng, +5 authors, Qiang Ao.
Molecules, 2021 Mar 07; 26(5). PMID: 33668746    Free PMC article.
Review.
The Roles of Immunoregulatory Networks in Severe Drug Hypersensitivity.
Yun-Shiuan Olivia Hsu, Kun-Lin Lu, +8 authors, Chun-Bing Chen.
Front Immunol, 2021 Mar 16; 12. PMID: 33717075    Free PMC article.
Review.
Underlying mechanisms and drug intervention strategies for the tumour microenvironment.
Haoze Li, Lihong Zhou, +2 authors, Qing Ji.
J Exp Clin Cancer Res, 2021 Mar 17; 40(1). PMID: 33722297    Free PMC article.
Review.
Nivolumab-Induced Thrombotic Thrombocytopenic Purpura in a Patient with Anal Squamous Cell Carcinoma: A Lesson on Hematologic Toxicity from Immunotherapy.
Mansour Gergi, Kara K Landry, +3 authors, Diego Adrianzen Herrera.
Oncologist, 2020 Oct 06; 25(12). PMID: 33017484    Free PMC article.
Review.
Genetic and non-genetic clonal diversity in cancer evolution.
James R M Black, Nicholas McGranahan.
Nat Rev Cancer, 2021 Mar 18; 21(6). PMID: 33727690
Review.
The discovery and development of oncolytic viruses: are they the future of cancer immunotherapy?
Shunchuan Zhang, Samuel D Rabkin.
Expert Opin Drug Discov, 2020 Nov 25; 16(4). PMID: 33232188    Free PMC article.
Review.
A pan-cancer analysis of the human tumor coagulome and its link to the tumor immune microenvironment.
Zuzana Saidak, Simon Soudet, +4 authors, Antoine Galmiche.
Cancer Immunol Immunother, 2020 Oct 16; 70(4). PMID: 33057845
A New Method for Optimizing Sepsis Therapy by Nivolumab and Meropenem Combination: Importance of Early Intervention and CTL Reinvigoration Rate as a Response Marker.
Avi Gillis, Anat Ben Yaacov, Zvia Agur.
Front Immunol, 2021 Mar 19; 12. PMID: 33732241    Free PMC article.
Immunotherapy Goes Local: The Central Role of Lymph Nodes in Driving Tumor Infiltration and Efficacy.
Kim M van Pul, Marieke F Fransen, Rieneke van de Ven, Tanja D de Gruijl.
Front Immunol, 2021 Mar 19; 12. PMID: 33732264    Free PMC article.
Review.
Adaptive Mechanisms of Tumor Therapy Resistance Driven by Tumor Microenvironment.
Peijie Wu, Wei Gao, +4 authors, Na Xie.
Front Cell Dev Biol, 2021 Mar 19; 9. PMID: 33732706    Free PMC article.
Review.
Next generation of immune checkpoint inhibitors and beyond.
Julian A Marin-Acevedo, ErinMarie O Kimbrough, Yanyan Lou.
J Hematol Oncol, 2021 Mar 21; 14(1). PMID: 33741032    Free PMC article.
Review.
Use of checkpoint inhibitors in patients with lymphoid malignancies receiving allogeneic cell transplantation: a review.
Sabela Bobillo, Juan Camilo Nieto, Pere Barba.
Bone Marrow Transplant, 2021 Mar 21; 56(8). PMID: 33742152
Review.
Newly diagnosed cardiovascular disease in patients treated with immune checkpoint inhibitors: a retrospective analysis of patients at an academic tertiary care center.
Nida Waheed, Michael G Fradley, +9 authors, Yan Gong.
Cardiooncology, 2021 Mar 20; 7(1). PMID: 33736707    Free PMC article.
The Role of Immune Checkpoint Molecules for Relapse After Allogeneic Hematopoietic Cell Transplantation.
Natalie Köhler, Dietrich Alexander Ruess, Rebecca Kesselring, Robert Zeiser.
Front Immunol, 2021 Mar 23; 12. PMID: 33746972    Free PMC article.
Review.
Releasing the brakes of tumor immunity with anti-PD-L1 and pushing its accelerator with L19-IL2 cures poorly immunogenic tumors when combined with radiotherapy.
Veronica Olivo Pimentel, Damiënne Marcus, +8 authors, Philippe Lambin.
J Immunother Cancer, 2021 Mar 11; 9(3). PMID: 33688020    Free PMC article.
Quantitative Systems Pharmacology Approaches for Immuno-Oncology: Adding Virtual Patients to the Development Paradigm.
Vijayalakshmi Chelliah, Georgia Lazarou, +36 authors, Andrzej M Kierzek.
Clin Pharmacol Ther, 2020 Jul 21; 109(3). PMID: 32686076    Free PMC article.
Review.
Biomarkers for Immunotherapy of Oral Squamous Cell Carcinoma: Current Status and Challenges.
Alhadi Almangush, Ilmo Leivo, Antti A Mäkitie.
Front Oncol, 2021 Mar 26; 11. PMID: 33763354    Free PMC article.
Review.
MicroRNA-34a: Potent Tumor Suppressor, Cancer Stem Cell Inhibitor, and Potential Anticancer Therapeutic.
Wen Jess Li, Yunfei Wang, +4 authors, Dean G Tang.
Front Cell Dev Biol, 2021 Mar 26; 9. PMID: 33763422    Free PMC article.
Review.
Insulin-mediated immune dysfunction in the development of preeclampsia.
Gustav van Niekerk, Claudia Christowitz, Anna-Mart Engelbrecht.
J Mol Med (Berl), 2021 Mar 27; 99(7). PMID: 33768298
Review.
Oncolytic virotherapy induced CSDE1 neo-antigenesis restricts VSV replication but can be targeted by immunotherapy.
Timothy Kottke, Jason Tonne, +19 authors, Richard G Vile.
Nat Commun, 2021 Mar 28; 12(1). PMID: 33772027    Free PMC article.
Functional crosstalk between T cells and monocytes in cancer and atherosclerosis.
Lindsey E Padgett, Daniel J Araujo, Catherine C Hedrick, Claire E Olingy.
J Leukoc Biol, 2020 Jun 13; 108(1). PMID: 32531833    Free PMC article.
Review.
Expert Perspective: Immune Checkpoint Inhibitors and Rheumatologic Complications.
Laura C Cappelli, Clifton O Bingham.
Arthritis Rheumatol, 2020 Nov 14; 73(4). PMID: 33186490    Free PMC article.
Review.
Epigenetic regulation of T cell adaptive immunity.
Adolfo B Frias, Shannon K Boi, Xin Lan, Ben Youngblood.
Immunol Rev, 2021 Mar 02; 300(1). PMID: 33644866    Free PMC article.
Review.
Effect of cabazitaxel on macrophages improves CD47-targeted immunotherapy for triple-negative breast cancer.
Xu Cao, Bolei Li, +12 authors, Mingye Feng.
J Immunother Cancer, 2021 Mar 24; 9(3). PMID: 33753567    Free PMC article.
High mutation burden in the checkpoint and micro-RNA processing genes in myelodysplastic syndrome.
Ivan Sergeevich Moiseev, Nikolay Yurevich Tcvetkov, +9 authors, Elena Vladislavovna Morozova.
PLoS One, 2021 Mar 18; 16(3). PMID: 33730109    Free PMC article.
Targeting loss of heterozygosity for cancer-specific immunotherapy.
Michael S Hwang, Brian J Mog, +12 authors, Kenneth W Kinzler.
Proc Natl Acad Sci U S A, 2021 Mar 19; 118(12). PMID: 33731480    Free PMC article.
Reconsidering the Meaning of Curing Primary Breast Cancer as a Systemic Disease.
Ryungsa Kim, Takanori Kin.
Front Oncol, 2021 Apr 06; 11. PMID: 33816282    Free PMC article.
Immune-Related Mutational Landscape and Gene Signatures: Prognostic Value and Therapeutic Impact for Head and Neck Cancer.
Bohai Feng, Jochen Hess.
Cancers (Basel), 2021 Apr 04; 13(5). PMID: 33800421    Free PMC article.
Review.
CTLA-4 in Regulatory T Cells for Cancer Immunotherapy.
Navid Sobhani, Dana Rae Tardiel-Cyril, +3 authors, Yong Li.
Cancers (Basel), 2021 Apr 04; 13(6). PMID: 33809974    Free PMC article.
Review.
Atypical anti-glomerular basement membrane glomerulonephritis in a patient with metastatic melanoma treated with mitogen-activated protein kinase and immune checkpoint inhibitors: a case report.
Periklis Kyriazis, Abhinav Tiwary, +2 authors, Gregory Braden.
J Med Case Rep, 2021 Apr 04; 15(1). PMID: 33810799    Free PMC article.
Inhibition of vascular adhesion protein-1 enhances the anti-tumor effects of immune checkpoint inhibitors.
Tomonari Kinoshita, Mohammad Abu Sayem, +7 authors, Yutaka Kawakami.
Cancer Sci, 2021 Jan 17; 112(4). PMID: 33453147    Free PMC article.
Immunotherapy in Advanced Biliary Tract Cancers.
Alice Boilève, Marc Hilmi, +3 authors, David Malka.
Cancers (Basel), 2021 Apr 04; 13(7). PMID: 33805461    Free PMC article.
Review.
A Genetic Mouse Model Recapitulates Immune Checkpoint Inhibitor-Associated Myocarditis and Supports a Mechanism-Based Therapeutic Intervention.
Spencer C Wei, Wouter C Meijers, +24 authors, James P Allison.
Cancer Discov, 2020 Dec 02; 11(3). PMID: 33257470    Free PMC article.
Atlas of breast cancer infiltrated B-lymphocytes revealed by paired single-cell RNA-sequencing and antigen receptor profiling.
Qingtao Hu, Yu Hong, +10 authors, Yu Zhang.
Nat Commun, 2021 Apr 14; 12(1). PMID: 33846305    Free PMC article.
A snapshot of the PD-1/PD-L1 pathway.
Chinmoy Ghosh, Gary Luong, Yue Sun.
J Cancer, 2021 Apr 16; 12(9). PMID: 33854633    Free PMC article.
Review.
A novel panel based on immune infiltration and tumor mutational burden for prognostic prediction in hepatocellular carcinoma.
Chan Xie, Hewei Wu, +6 authors, Liang Peng.
Aging (Albany NY), 2021 Mar 14; 13(6). PMID: 33714200    Free PMC article.
Fascin inhibitor increases intratumoral dendritic cell activation and anti-cancer immunity.
Yufeng Wang, Mei Song, +6 authors, Xin-Yun Huang.
Cell Rep, 2021 Apr 08; 35(1). PMID: 33826900    Free PMC article.
T Cell Receptor Engineered Lymphocytes for Cancer Therapy.
Meagan R Rollins, Ellen J Spartz, Ingunn M Stromnes.
Curr Protoc Immunol, 2020 May 21; 129(1). PMID: 32432843    Free PMC article.
In vivo CD8+ T cell CRISPR screening reveals control by Fli1 in infection and cancer.
Zeyu Chen, Eri Arai, +25 authors, Junwei Shi.
Cell, 2021 Feb 27; 184(5). PMID: 33636129    Free PMC article.
High tumor mutation burden fails to predict immune checkpoint blockade response across all cancer types.
D J McGrail, P G Pilié, +13 authors, S-Y Lin.
Ann Oncol, 2021 Mar 20; 32(5). PMID: 33736924    Free PMC article.
Systematic review and meta-analysis efficacy and safety of immune checkpoint inhibitors in advanced melanoma patients with anti-PD-1 progression: a systematic review and meta-analysis.
N N Alrabadi, H M Abushukair, +9 authors, F A Al Qarqaz.
Clin Transl Oncol, 2021 Apr 21; 23(9). PMID: 33877531
Systematic Review.
Optimized polyepitope neoantigen DNA vaccines elicit neoantigen-specific immune responses in preclinical models and in clinical translation.
Lijin Li, Xiuli Zhang, +15 authors, William E Gillanders.
Genome Med, 2021 Apr 22; 13(1). PMID: 33879241    Free PMC article.
Emerging strategies for treating metastasis.
Mark Esposito, Shridar Ganesan, Yibin Kang.
Nat Cancer, 2021 Apr 27; 2(3). PMID: 33899000    Free PMC article.
Metabolic barriers to cancer immunotherapy.
Kristin DePeaux, Greg M Delgoffe.
Nat Rev Immunol, 2021 May 01; 21(12). PMID: 33927375    Free PMC article.
Review.
A pan-cancer analysis of CpG Island gene regulation reveals extensive plasticity within Polycomb target genes.
Yueyuan Zheng, Guowei Huang, +5 authors, Benjamin P Berman.
Nat Commun, 2021 May 02; 12(1). PMID: 33931649    Free PMC article.
Anti-Angiogenic Therapy: Current Challenges and Future Perspectives.
Filipa Lopes-Coelho, Filipa Martins, Sofia A Pereira, Jacinta Serpa.
Int J Mol Sci, 2021 May 01; 22(7). PMID: 33916438    Free PMC article.
Review.
Recent Advances to Augment NK Cell Cancer Immunotherapy Using Nanoparticles.
Kwang-Soo Kim, Dong-Hwan Kim, Dong-Hyun Kim.
Pharmaceutics, 2021 May 01; 13(4). PMID: 33918941    Free PMC article.
Review.
The Future of Cancer Diagnosis, Treatment and Surveillance: A Systemic Review on Immunotherapy and Immuno-PET Radiotracers.
Virginia Liberini, Riccardo Laudicella, +5 authors, Désirée Deandreis.
Molecules, 2021 May 01; 26(8). PMID: 33920423    Free PMC article.
Systematic Review.
Lights and Shadows on Managing Immune Checkpoint Inhibitors in Oncology during the COVID-19 Era.
Chiara Burgaletto, Oronzo Brunetti, +4 authors, Antonella Argentiero.
Cancers (Basel), 2021 May 01; 13(8). PMID: 33921021    Free PMC article.
Leukocyte immunoglobulin-like receptor subfamily B: therapeutic targets in cancer.
Mi Deng, Heyu Chen, +8 authors, Cheng Cheng Zhang.
Antib Ther, 2021 May 01; 4(1). PMID: 33928233    Free PMC article.
Review.
Evolutionary genetic algorithm identifies IL2RB as a potential predictive biomarker for immune-checkpoint therapy in colorectal cancer.
Matthew Alderdice, Stephanie G Craig, +12 authors, Darragh G McArt.
NAR Genom Bioinform, 2021 May 01; 3(2). PMID: 33928242    Free PMC article.
Immune Modulation Plus Tumor Ablation: Adjuvants and Antibodies to Prime and Boost Anti-Tumor Immunity In Situ.
Renske J E van den Bijgaart, Fabian Schuurmans, +3 authors, Gosse J Adema.
Front Immunol, 2021 May 04; 12. PMID: 33936033    Free PMC article.
Review.
Emerging avenues in immunotherapy for the management of malignant pleural mesothelioma.
Steven G Gray.
BMC Pulm Med, 2021 May 07; 21(1). PMID: 33952230    Free PMC article.
Review.
Epigenetic silencing by SETDB1 suppresses tumour intrinsic immunogenicity.
Gabriel K Griffin, Jingyi Wu, +26 authors, Bradley E Bernstein.
Nature, 2021 May 07; 595(7866). PMID: 33953401
Expression pattern of m6A regulators is significantly correlated with malignancy and antitumor immune response of breast cancer.
Xiaofang He, Liqiang Tan, Jing Ni, Guoping Shen.
Cancer Gene Ther, 2020 Aug 08; 28(3-4). PMID: 32759989    Free PMC article.
Digital Display Precision Predictor: the prototype of a global biomarker model to guide treatments with targeted therapy and predict progression-free survival.
Vladimir Lazar, Shai Magidi, +22 authors, Richard L Schilsky.
NPJ Precis Oncol, 2021 Apr 30; 5(1). PMID: 33911192    Free PMC article.
Co-administration of combretastatin A4 nanoparticles and anti-PD-L1 for synergistic therapy of hepatocellular carcinoma.
Bonan Zhao, Zhipeng Dong, +4 authors, Yue Wang.
J Nanobiotechnology, 2021 May 03; 19(1). PMID: 33933077    Free PMC article.
Targeted Therapy Given after Anti-PD-1 Leads to Prolonged Responses in Mouse Melanoma Models through Sustained Antitumor Immunity.
Manali S Phadke, Zhihua Chen, +17 authors, Keiran S M Smalley.
Cancer Immunol Res, 2021 Mar 04; 9(5). PMID: 33653716    Free PMC article.
Development of a single-chain fragment variable fused-mutant HALT-1 recombinant immunotoxin against G12V mutated KRAS colorectal cancer cells.
Michelle Yee Mun Teo, Jeremy Jeack Ceen Ng, +4 authors, Lionel Lian Aun In.
PeerJ, 2021 May 08; 9. PMID: 33959410    Free PMC article.
Emerging principles of brain immunology and immune checkpoint blockade in brain metastases.
Jawad Fares, Ilya Ulasov, Peter Timashev, Maciej S Lesniak.
Brain, 2021 Apr 25; 144(4). PMID: 33893488    Free PMC article.
Review.
Biological bases of cancer immunotherapy.
Maryanne M Gonzales Carazas, Joseph A Pinto, Fanny L Casado.
Expert Rev Mol Med, 2021 Mar 26; 23. PMID: 33762030    Free PMC article.
Cytotoxic lymphocytes target characteristic biophysical vulnerabilities in cancer.
Maria Tello-Lafoz, Katja Srpan, +12 authors, Ekrem Emrah Er.
Immunity, 2021 Mar 24; 54(5). PMID: 33756102    Free PMC article.
Resistance to Immune Checkpoint Blockade in Uterine Leiomyosarcoma: What Can We Learn from Other Cancer Types?
Wout De Wispelaere, Daniela Annibali, +2 authors, Frédéric Amant.
Cancers (Basel), 2021 May 01; 13(9). PMID: 33922556    Free PMC article.
Review.
Advances in Targeting Cutaneous Melanoma.
Dimitri Kasakovski, Marina Skrygan, Thilo Gambichler, Laura Susok.
Cancers (Basel), 2021 May 01; 13(9). PMID: 33925915    Free PMC article.
Review.
The Iron Curtain: Macrophages at the Interface of Systemic and Microenvironmental Iron Metabolism and Immune Response in Cancer.
Angela DeRosa, Avigdor Leftin.
Front Immunol, 2021 May 15; 12. PMID: 33986740    Free PMC article.
Review.
Comprehensive analysis of tumor microenvironment and identification of an immune signature to predict the prognosis and immunotherapeutic response in lung squamous cell carcinoma.
Jinlong Wu, Chengfeng Xu, +4 authors, Mingsong Wang.
Ann Transl Med, 2021 May 15; 9(7). PMID: 33987267    Free PMC article.
Immune Checkpoint Inhibitors: A Promising Treatment Option for Metastatic Castration-Resistant Prostate Cancer?
Vicenç Ruiz de Porras, Juan Carlos Pardo, +2 authors, Albert Font.
Int J Mol Sci, 2021 May 06; 22(9). PMID: 33946818    Free PMC article.
Review.
Neoantigen landscape in metastatic nasopharyngeal carcinoma.
Mei Lin, Xiao-Long Zhang, +20 authors, Ming-Yuan Chen.
Theranostics, 2021 May 18; 11(13). PMID: 33995666    Free PMC article.
Case Report: Immune Checkpoint Inhibitor-Induced Exuberant Tumor Inflammation With Accelerated Clinical Deterioration in Metastatic Renal Cell Carcinoma.
Dharmesh Gopalakrishnan, Rohit K Jain, +8 authors, Saby George.
Front Oncol, 2021 May 18; 11. PMID: 33996609    Free PMC article.
A participant-derived xenograft model of HIV enables long-term evaluation of autologous immunotherapies.
Chase D McCann, Christiaan H van Dorp, +16 authors, R Brad Jones.
J Exp Med, 2021 May 15; 218(7). PMID: 33988715    Free PMC article.
Optimizing immunotherapy for gynecologic cancers.
Maria M Rubinstein, Vicky Makker.
Curr Opin Obstet Gynecol, 2019 Dec 14; 32(1). PMID: 31833942    Free PMC article.
Review.
The effects of targeted immune-regulatory strategies on tumor-specific T-cell responses in vitro.
Mario Presti, Marie Christine Wulff Westergaard, +4 authors, Marco Donia.
Cancer Immunol Immunother, 2020 Nov 10; 70(6). PMID: 33165629
Targeting PIM1-Mediated Metabolism in Myeloid Suppressor Cells to Treat Cancer.
Gang Xin, Yao Chen, +11 authors, Weiguo Cui.
Cancer Immunol Res, 2021 Feb 14; 9(4). PMID: 33579728    Free PMC article.
Beyond cancer cells: Targeting the tumor microenvironment with gene therapy and armed oncolytic virus.
Peter Kok-Ting Wan, Anderson J Ryan, Leonard W Seymour.
Mol Ther, 2021 Apr 13; 29(5). PMID: 33845199    Free PMC article.
Review.
CD137 (4-1BB) stimulation leads to metabolic and functional reprogramming of human monocytes/macrophages enhancing their tumoricidal activity.
A Stoll, H Bruns, +6 authors, D Mougiakakos.
Leukemia, 2021 May 23; 35(12). PMID: 34021248    Free PMC article.
In vitro assessment of antitumor immune responses using tumor antigen proteins produced by transgenic silkworms.
Kanae Yamada, Kei Masuda, +8 authors, Shigeki Takeda.
J Mater Sci Mater Med, 2021 May 18; 32(6). PMID: 33999320    Free PMC article.
Natural Killer Cell Interactions With Myeloid Derived Suppressor Cells in the Tumor Microenvironment and Implications for Cancer Immunotherapy.
Cristina Zalfa, Silke Paust.
Front Immunol, 2021 May 25; 12. PMID: 34025641    Free PMC article.
Review.
Immunomodulatory Effects of BRAF, MEK, and CDK4/6 Inhibitors: Implications for Combining Targeted Therapy and Immune Checkpoint Blockade for the Treatment of Melanoma.
Emily J Lelliott, Grant A McArthur, Jane Oliaro, Karen E Sheppard.
Front Immunol, 2021 May 25; 12. PMID: 34025662    Free PMC article.
Review.
Identification of combinations of somatic mutations that predict cancer survival and immunotherapy benefit.
Ayal B Gussow, Eugene V Koonin, Noam Auslander.
NAR Cancer, 2021 May 25; 3(2). PMID: 34027407    Free PMC article.
Targeting Trained Innate Immunity With Nanobiologics to Treat Cardiovascular Disease.
Abraham J P Teunissen, Mandy M T van Leent, +5 authors, Willem J M Mulder.
Arterioscler Thromb Vasc Biol, 2021 Apr 23; 41(6). PMID: 33882685    Free PMC article.
Review.
Mechanisms of Cardiovascular Toxicities Associated With Immunotherapies.
Alan H Baik, Olalekan O Oluwole, +4 authors, Javid J Moslehi.
Circ Res, 2021 May 04; 128(11). PMID: 33934609    Free PMC article.
Review.
Combining a Universal Telomerase Based Cancer Vaccine With Ipilimumab in Patients With Metastatic Melanoma - Five-Year Follow Up of a Phase I/IIa Trial.
Elin Aamdal, Else Marit Inderberg, +10 authors, Gustav Gaudernack.
Front Immunol, 2021 May 29; 12. PMID: 34046035    Free PMC article.
Immunomodulation by the Commensal Microbiome During Immune-Targeted Interventions: Focus on Cancer Immune Checkpoint Inhibitor Therapy and Vaccination.
Abigail L Reens, Damien J Cabral, +4 authors, Gokul Swaminathan.
Front Immunol, 2021 Jun 01; 12. PMID: 34054810    Free PMC article.
Review.
Local and Targeted Delivery of Immune Checkpoint Blockade Therapeutics.
Xiao Han, Hongjun Li, +2 authors, Zhen Gu.
Acc Chem Res, 2020 Oct 20; 53(11). PMID: 33073988    Free PMC article.
Impact of COVID-19 in patients with lymphoid malignancies.
John Charles Riches.
World J Virol, 2021 Jun 04; 10(3). PMID: 34079692    Free PMC article.
Review.
Quantitative phosphoproteomic analysis reveals involvement of PD-1 in multiple T cell functions.
Anna S Tocheva, Michael Peled, +9 authors, Adam Mor.
J Biol Chem, 2020 Oct 21; 295(52). PMID: 33077516    Free PMC article.
Synergistic immunotherapy of glioblastoma by dual targeting of IL-6 and CD40.
Fan Yang, Zhenqiang He, +15 authors, Yi Fan.
Nat Commun, 2021 Jun 10; 12(1). PMID: 34103524    Free PMC article.
Association of immune-related adverse events induced by nivolumab with a battery of autoantibodies.
Iñigo Les, Mireia Martínez, +7 authors, Severina Domínguez.
Ann Med, 2021 Jun 02; 53(1). PMID: 34060971    Free PMC article.
Hereditary Leiomyomatosis and Renal Cell Cancer: Recent Insights Into Mechanisms and Systemic Treatment.
Congwang Zhang, Lijun Li, Yipeng Zhang, Changchun Zeng.
Front Oncol, 2021 Jun 12; 11. PMID: 34113573    Free PMC article.
Review.
Progress for Immunotherapy in Inflammatory Breast Cancer and Emerging Barriers to Therapeutic Efficacy.
Regina M Koch, Daniel R Principe, Jose L Cataneo, Ajay Rana.
Cancers (Basel), 2021 Jun 03; 13(11). PMID: 34067257    Free PMC article.
Review.
Magnetic Nanostructures as Emerging Therapeutic Tools to Boost Anti-Tumour Immunity.
Stefano Persano, Pradip Das, Teresa Pellegrino.
Cancers (Basel), 2021 Jun 03; 13(11). PMID: 34073106    Free PMC article.
Review.
FDG PET/CT for Assessment of Immune Therapy: Opportunities and Understanding Pitfalls.
Steve Y Cho, Daniel T Huff, Robert Jeraj, Mark R Albertini.
Semin Nucl Med, 2020 Oct 17; 50(6). PMID: 33059821    Free PMC article.
Review.
Comprehensive Profiling Reveals Distinct Microenvironment and Metabolism Characterization of Lung Adenocarcinoma.
Chang Li, Chen Tian, +11 authors, Li Liu.
Front Genet, 2021 Jun 15; 12. PMID: 34122500    Free PMC article.
P32-specific CAR T cells with dual antitumor and antiangiogenic therapeutic potential in gliomas.
Liat Rousso-Noori, Ignacio Mastandrea, +7 authors, Dinorah Friedmann-Morvinski.
Nat Commun, 2021 Jun 16; 12(1). PMID: 34127674    Free PMC article.
Mechanism-based treatment of cancer with immune checkpoint inhibitor therapies.
Yara Abdou, Manu Pandey, +3 authors, Marc S Ernstoff.
Br J Clin Pharmacol, 2020 Apr 24; 86(9). PMID: 32323342    Free PMC article.
Review.
Relationship between microsatellite status and immune microenvironment of colorectal cancer and its application to diagnosis and treatment.
Junge Bai, Hongsheng Chen, Xuefeng Bai.
J Clin Lab Anal, 2021 May 04; 35(6). PMID: 33938589    Free PMC article.
Review.
Immune checkpoint inhibitor-associated acute kidney injury and mortality: An observational study.
Marije S Koks, Gurbey Ocak, +6 authors, Meriem Khairoun.
PLoS One, 2021 Jun 09; 16(6). PMID: 34101756    Free PMC article.
Cutaneous squamous-cell carcinoma of the head-neck area refractory to chemo-radiotherapy: benefit from anti-PD-1 immunotherapy.
Ioannis M Koukourakis, Axiotis G Giakzidis, +4 authors, Michael I Koukourakis.
BJR Case Rep, 2021 Jun 17; 7(3). PMID: 34131497    Free PMC article.
Immunotherapy in endometrial cancer: rationale, practice and perspectives.
Wenyu Cao, Xinyue Ma, +3 authors, Qing Zhang.
Biomark Res, 2021 Jun 18; 9(1). PMID: 34134781    Free PMC article.
Review.
Overall survival in metastatic melanoma correlates with pembrolizumab exposure and T cell exhaustion markers.
Vishal Navani, Moira C Graves, +3 authors, Andre van der Westhuizen.
Pharmacol Res Perspect, 2021 Jun 16; 9(4). PMID: 34129290    Free PMC article.
The emerging landscape of immune checkpoint inhibitor based clinical trials in adults with advanced rare tumors.
Arjun Mittra, Naoko Takebe, +2 authors, Abdul Rafeh Naqash.
Hum Vaccin Immunother, 2020 Dec 17; 17(7). PMID: 33325769    Free PMC article.
Review.
Neoadjuvant immunotherapy for non-small cell lung cancer: right drugs, right patient, right time?
Elizabeth Ahern, Ben J Solomon, +3 authors, Brett G M Hughes.
J Immunother Cancer, 2021 Jun 05; 9(6). PMID: 34083418    Free PMC article.
Review.
Regulatory T-Cells as an Emerging Barrier to Immune Checkpoint Inhibition in Lung Cancer.
Daniel R Principe, Lauren Chiec, Nisha A Mohindra, Hidayatullah G Munshi.
Front Oncol, 2021 Jun 19; 11. PMID: 34141625    Free PMC article.
Review.
Applications of Organoids for Cancer Biology and Precision Medicine.
Yuan-Hung Lo, Kasper Karlsson, Calvin J Kuo.
Nat Cancer, 2021 Jun 19; 1(8). PMID: 34142093    Free PMC article.
CTLA-4 Expression and Its Clinical Significance in Breast Cancer.
Rodrigo Kern, Carolina Panis.
Arch Immunol Ther Exp (Warsz), 2021 Jun 21; 69(1). PMID: 34148159
Systematic Review.
Outcomes associated with immune-related adverse events in metastatic non-small cell lung cancer treated with nivolumab: a pooled exploratory analysis from a global cohort.
Abdul Rafeh Naqash, Biagio Ricciuti, +15 authors, Paul R Walker.
Cancer Immunol Immunother, 2020 Mar 07; 69(7). PMID: 32140762
Clinical and pathologic features associated with PD-L1 (SP142) expression in stromal tumor-infiltrating immune cells of triple-negative breast carcinoma.
Raza Syed Hoda, Edi Brogi, +10 authors, Hannah Yong Wen.
Mod Pathol, 2020 Jul 03; 33(11). PMID: 32612248    Free PMC article.
Applications of Single-Cell Omics in Tumor Immunology.
Junwei Liu, Saisi Qu, +5 authors, Weiwei Yin.
Front Immunol, 2021 Jun 29; 12. PMID: 34177965    Free PMC article.
Review.
Sarcoma Tumor Microenvironment.
Panagiotis Tsagozis, Jordi Gonzalez-Molina, +5 authors, Monika Ehnman.
Adv Exp Med Biol, 2020 Jan 01; 1296. PMID: 34185302
Microfluidics sorting enables the isolation of an intact cellular pair complex of CD8+ T cells and antigen-presenting cells in a cognate antigen recognition-dependent manner.
Soichiro Kuwabara, Yoshihiko Tanimoto, +4 authors, Taiki Aoshi.
PLoS One, 2021 Jun 15; 16(6). PMID: 34125844    Free PMC article.
Integrated transcriptional-phenotypic analysis captures systemic immunomodulation following antiangiogenic therapy in renal cell carcinoma patients.
Darawan Rinchai, Elena Verzoni, +15 authors, Licia Rivoltini.
Clin Transl Med, 2021 Jun 30; 11(6). PMID: 34185403    Free PMC article.
Neoadjuvant Immunotherapy for High-Risk, Resectable Malignancies: Scientific Rationale and Clinical Challenges.
Mithunah Krishnamoorthy, John G Lenehan, Saman Maleki Vareki.
J Natl Cancer Inst, 2021 Jan 13; 113(7). PMID: 33432320    Free PMC article.
Review.
FDA Approval Summary: Nivolumab with Ipilimumab and Chemotherapy for Metastatic Non-small Cell Lung Cancer, A Collaborative Project Orbis Review.
Paz J Vellanki, Flora Mulkey, +16 authors, Harpreet Singh.
Clin Cancer Res, 2021 Feb 27; 27(13). PMID: 33632925    Free PMC article.
Combining AFM13, a Bispecific CD30/CD16 Antibody, with Cytokine-Activated Blood and Cord Blood-Derived NK Cells Facilitates CAR-like Responses Against CD30+ Malignancies.
Lucila N Kerbauy, Nancy D Marin, +40 authors, Katayoun Rezvani.
Clin Cancer Res, 2021 May 15; 27(13). PMID: 33986022    Free PMC article.
Two Complementarity Immunotherapeutics in Non-Small-Cell Lung Cancer Patients-Mechanism of Action and Future Concepts.
Kamila Wojas-Krawczyk, Paweł Krawczyk, Michał Gil, Maciej Strzemski.
Cancers (Basel), 2021 Jul 03; 13(11). PMID: 34200219    Free PMC article.
Review.
TremelImumab and Durvalumab Combination for the Non-OperatIve Management (NOM) of Microsatellite InstabiliTY (MSI)-High Resectable Gastric or Gastroesophageal Junction Cancer: The Multicentre, Single-Arm, Multi-Cohort, Phase II INFINITY Study.
Alessandra Raimondi, Federica Palermo, +29 authors, Filippo Pietrantonio.
Cancers (Basel), 2021 Jul 03; 13(11). PMID: 34200267    Free PMC article.
Immunomodulatory mAbs as Tools to Investigate on Cis-Interaction of PD-1/PD-L1 on Tumor Cells and to Set Up Methods for Early Screening of Safe and Potent Combinatorial Treatments.
Cinzia Vetrei, Margherita Passariello, +3 authors, Claudia De Lorenzo.
Cancers (Basel), 2021 Jul 03; 13(12). PMID: 34201082    Free PMC article.
Strength and Numbers: The Role of Affinity and Avidity in the 'Quality' of T Cell Tolerance.
Sébastien This, Stefanie F Valbon, Marie-Ève Lebel, Heather J Melichar.
Cells, 2021 Jul 03; 10(6). PMID: 34204485    Free PMC article.
Review.
Targeted Treatment of Head and Neck (Pre)Cancer: Preclinical Target Identification and Development of Novel Therapeutic Applications.
Anne M van Harten, Ruud H Brakenhoff.
Cancers (Basel), 2021 Jul 03; 13(11). PMID: 34204886    Free PMC article.
Review.
An Updated Understanding of the Role of YAP in Driving Oncogenic Responses.
Giampaolo Morciano, Bianca Vezzani, +3 authors, Carlotta Giorgi.
Cancers (Basel), 2021 Jul 03; 13(12). PMID: 34205830    Free PMC article.
Review.
Inhibitors of immune checkpoints-PD-1, PD-L1, CTLA-4-new opportunities for cancer patients and a new challenge for internists and general practitioners.
Marek Z Wojtukiewicz, Magdalena M Rek, +7 authors, Kenneth V Honn.
Cancer Metastasis Rev, 2021 Jul 09; 40(3). PMID: 34236546    Free PMC article.
Review.
Emerging Roles of Liquid-Liquid Phase Separation in Cancer: From Protein Aggregation to Immune-Associated Signaling.
Jiahua Lu, Junjie Qian, +4 authors, Wu Zhang.
Front Cell Dev Biol, 2021 Jul 09; 9. PMID: 34235141    Free PMC article.
Review.
DNA damage repair: historical perspectives, mechanistic pathways and clinical translation for targeted cancer therapy.
Ruixue Huang, Ping-Kun Zhou.
Signal Transduct Target Ther, 2021 Jul 10; 6(1). PMID: 34238917    Free PMC article.
Review.
Immune Aging and Immunotherapy in Cancer.
Melanie Kaiser, Maria Donatella Semeraro, +3 authors, Wilfried Renner.
Int J Mol Sci, 2021 Jul 03; 22(13). PMID: 34209842    Free PMC article.
Review.
The role of Exosomes in the Pathogenesis of Nasopharyngeal Carcinoma and the involved Clinical Application.
Huidan Luo, Bin Yi.
Int J Biol Sci, 2021 Jul 10; 17(9). PMID: 34239345    Free PMC article.
Review.
A Pilot Study of Whether the Cold-Heat Syndrome Type is Associated with Treatment Response and Immune Status in Patients with Non-Small Cell Lung Cancer.
Yujin Choi, Ojin Kwon, Chang-Min Choi, Mi-Kyung Jeong.
Evid Based Complement Alternat Med, 2021 Jul 10; 2021. PMID: 34239594    Free PMC article.
The mechanisms of action of Plasmodium infection against cancer.
Xiaoping Chen, Li Qin, Wen Hu, Dickson Adah.
Cell Commun Signal, 2021 Jul 11; 19(1). PMID: 34243757    Free PMC article.
Review.
Cost-effectiveness analysis of the use of immunotherapy in metastatic solid tumours in Austria by applying the ESMO-Magnitude of Clinical Benefit Scale (ESMO-MCBS) version 1.1.
M Pichler, J Steyrer.
ESMO Open, 2021 Jun 28; 6(4). PMID: 34175674    Free PMC article.
Casp8 acts through A20 to inhibit PD-L1 expression: The mechanism and its implication in immunotherapy.
Jiahuan Zou, Hongwei Xia, +5 authors, Feng Bi.
Cancer Sci, 2021 May 03; 112(7). PMID: 33934451    Free PMC article.
Multimodal Molecular Imaging Detects Early Responses to Immune Checkpoint Blockade.
Yu Saida, Jeffrey R Brender, +3 authors, Shun Kishimoto.
Cancer Res, 2021 Apr 11; 81(13). PMID: 33837042    Free PMC article.
APOBEC and Cancer Viroimmunotherapy: Thinking the Unthinkable.
Richard G Vile, Alan Melcher, +2 authors, Jose S Pulido.
Clin Cancer Res, 2021 Feb 10; 27(12). PMID: 33558423    Free PMC article.
Review.
FOXA1 overexpression suppresses interferon signaling and immune response in cancer.
Yundong He, Liguo Wang, +26 authors, Haojie Huang.
J Clin Invest, 2021 Jun 09; 131(14). PMID: 34101624    Free PMC article.
Enriching CCL3 in the Tumor Microenvironment Facilitates T cell Responses and Improves the Efficacy of Anti-PD-1 Therapy.
Tae Gun Kang, Hyo Jin Park, +2 authors, Sang-Jun Ha.
Immune Netw, 2021 Jul 20; 21(3). PMID: 34277113    Free PMC article.
Resolution of tissue signatures of therapy response in patients with recurrent GBM treated with neoadjuvant anti-PD1.
Yue Lu, Alphonsus H C Ng, +8 authors, James R Heath.
Nat Commun, 2021 Jul 01; 12(1). PMID: 34188042    Free PMC article.
Pulsed focused ultrasound can improve the anti-cancer effects of immune checkpoint inhibitors in murine pancreatic cancer.
Petros X E Mouratidis, Marcia Costa, +2 authors, Gail Ter Haar.
J R Soc Interface, 2021 Jul 08; 18(180). PMID: 34229458    Free PMC article.
Adoptive T Cell Therapy with IL-12-Preconditioned Low-Avidity T Cells Prevents Exhaustion and Results in Enhanced T Cell Activation, Enhanced Tumor Clearance, and Decreased Risk for Autoimmunity.
Christopher G Tucker, Jason S Mitchell, +7 authors, Brian T Fife.
J Immunol, 2020 Aug 02; 205(5). PMID: 32737148    Free PMC article.
The Complex Integration of T-cell Metabolism and Immunotherapy.
Matthew Z Madden, Jeffrey C Rathmell.
Cancer Discov, 2021 Apr 03; 11(7). PMID: 33795235    Free PMC article.
Review.
Telomerase as a Target for Therapeutic Cancer Vaccines and Considerations for Optimizing Their Clinical Potential.
Espen Basmo Ellingsen, Sara M Mangsbo, Eivind Hovig, Gustav Gaudernack.
Front Immunol, 2021 Jul 23; 12. PMID: 34290704    Free PMC article.
Review.
Phase 1b study of pegylated arginine deiminase (ADI-PEG 20) plus Pembrolizumab in advanced solid cancers.
Kwang-Yu Chang, Nai-Jung Chiang, +16 authors, Li-Tzong Chen.
Oncoimmunology, 2021 Jul 23; 10(1). PMID: 34290906    Free PMC article.
A review on the role of gut microbiota in immune checkpoint blockade therapy for cancer.
Esther Kim, Hyeok Ahn, Hansoo Park.
Mamm Genome, 2021 Mar 31; 32(4). PMID: 33783613    Free PMC article.
Review.
Inflammation and tumor progression: signaling pathways and targeted intervention.
Huakan Zhao, Lei Wu, +4 authors, Yongsheng Li.
Signal Transduct Target Ther, 2021 Jul 13; 6(1). PMID: 34248142    Free PMC article.
Correlation analysis of tumor mutation burden of hepatocellular carcinoma based on data mining.
Weijie Zhou, Dalang Fang, Yongfei He, Jie Wei.
J Gastrointest Oncol, 2021 Jul 24; 12(3). PMID: 34295561    Free PMC article.
A narrative review of combined stereotactic ablative radiotherapy and immunotherapy in metastatic non-small cell lung cancer.
Zarique Z Akanda, Paul J Neeson, +5 authors, Shankar Siva.
Transl Lung Cancer Res, 2021 Jul 24; 10(6). PMID: 34295676    Free PMC article.
Review.
The Cancer-Immunity Cycle in Multiple Myeloma.
Mika Casey, Kyohei Nakamura.
Immunotargets Ther, 2021 Jul 24; 10. PMID: 34295843    Free PMC article.
Review.
Differentiation of exhausted CD8+ T cells after termination of chronic antigen stimulation stops short of achieving functional T cell memory.
Pierre Tonnerre, David Wolski, +27 authors, Georg M Lauer.
Nat Immunol, 2021 Jul 28; 22(8). PMID: 34312544    Free PMC article.
Immune-related toxicities of checkpoint inhibitors: mechanisms and mitigation strategies.
Ryan J Sullivan, Jeffrey S Weber.
Nat Rev Drug Discov, 2021 Jul 29;. PMID: 34316029
Review.
The Role of the Microenvironment and Immune System in Regulating Stem Cell Fate in Cancer.
L Paige Ferguson, Emily Diaz, Tannishtha Reya.
Trends Cancer, 2021 Jan 30; 7(7). PMID: 33509688    Free PMC article.
Review.
The Impact of Durvalumab on Local-Regional Control in Stage III NSCLCs Treated With Chemoradiation and on KEAP1-NFE2L2-Mutant Tumors.
Narek Shaverdian, Michael Offin, +8 authors, Daniel R Gomez.
J Thorac Oncol, 2021 May 17; 16(8). PMID: 33992811    Free PMC article.
Advances in Immunotherapy for Adult Glioblastoma.
Chirayu R Chokshi, Benjamin A Brakel, +4 authors, Sheila K Singh.
Cancers (Basel), 2021 Jul 25; 13(14). PMID: 34298615    Free PMC article.
Review.
Bi-specific and Tri-specific NK Cell Engagers: The New Avenue of Targeted NK Cell Immunotherapy.
Shee Kwan Phung, Jeffrey S Miller, Martin Felices.
Mol Diagn Ther, 2021 Jul 31; 25(5). PMID: 34327614
Review.
A TLR4 agonist improves immune checkpoint blockade treatment by increasing the ratio of effector to regulatory cells within the tumor microenvironment.
A Farias, A Soto, +5 authors, P M Berguer.
Sci Rep, 2021 Jul 30; 11(1). PMID: 34321536    Free PMC article.
CAFs Interacting With TAMs in Tumor Microenvironment to Enhance Tumorigenesis and Immune Evasion.
Gurcan Gunaydin.
Front Oncol, 2021 Aug 03; 11. PMID: 34336660    Free PMC article.
Review.
Identification of the Prognosis Value and Potential Mechanism of Immune Checkpoints in Renal Clear Cell Carcinoma Microenvironment.
Guodong Liao, Ping Wang, Yuyong Wang.
Front Oncol, 2021 Aug 03; 11. PMID: 34336706    Free PMC article.
Cryo-EM structures of inhibitory antibodies complexed with arginase 1 provide insight into mechanism of action.
Rachel L Palte, Veronica Juan, +22 authors, Giovanna Scapin.
Commun Biol, 2021 Jul 31; 4(1). PMID: 34326456    Free PMC article.
Nanocages displaying SIRP gamma clusters combined with prophagocytic stimulus of phagocytes potentiate anti-tumor immunity.
Yoonjeong Choi, Gi-Hoon Nam, +6 authors, In-San Kim.
Cancer Gene Ther, 2021 Aug 06; 28(9). PMID: 34349240
ST8Sia6 Promotes Tumor Growth in Mice by Inhibiting Immune Responses.
David J Friedman, Sydney B Crotts, +6 authors, Virginia Smith Shapiro.
Cancer Immunol Res, 2021 Jun 03; 9(8). PMID: 34074677    Free PMC article.
Prognostic Implications of Immune-Related Gene Pairs Signatures in Bladder Cancer.
Hui Xiong, Hui Gao, +9 authors, Weiting Kang.
J Oncol, 2021 Aug 07; 2021. PMID: 34354750    Free PMC article.
Targeted Alpha-Particle Radiotherapy and Immune Checkpoint Inhibitors Induces Cooperative Inhibition on Tumor Growth of Malignant Melanoma.
Mengshi Li, Dijie Liu, +8 authors, Michael K Schultz.
Cancers (Basel), 2021 Aug 08; 13(15). PMID: 34359580    Free PMC article.
A Spatial Quantitative Systems Pharmacology Platform spQSP-IO for Simulations of Tumor-Immune Interactions and Effects of Checkpoint Inhibitor Immunotherapy.
Chang Gong, Alvaro Ruiz-Martinez, Holly Kimko, Aleksander S Popel.
Cancers (Basel), 2021 Aug 08; 13(15). PMID: 34359653    Free PMC article.
Nanobiotechnology and Immunotherapy: Two Powerful and Cooperative Allies against Cancer.
Francesco Mainini, Francesca De Santis, +3 authors, Michael Eccles.
Cancers (Basel), 2021 Aug 08; 13(15). PMID: 34359665    Free PMC article.
Review.
Combining Cancer Vaccines with Immunotherapy: Establishing a New Immunological Approach.
Chang-Gon Kim, Yun-Beom Sang, Ji-Hyun Lee, Hong-Jae Chon.
Int J Mol Sci, 2021 Aug 08; 22(15). PMID: 34360800    Free PMC article.
Review.
Overcoming Therapeutic Challenges for Pancreatic Ductal Adenocarcinoma with xCT Inhibitors.
Milica Vucetic, Boutaina Daher, +2 authors, Jacques Pouyssegur.
Adv Exp Med Biol, 2021 Aug 10; 1301. PMID: 34370285
Quality of patient-reported outcomes in oncology clinical trials using immune checkpoint inhibitors: A systematic review.
Eoghan Malone, Reeta Barua, +3 authors, Aaron R Hansen.
Cancer Med, 2021 Jun 30; 10(15). PMID: 34184416    Free PMC article.
Systematic Review.
Clinical Research on the Mechanisms Underlying Immune Checkpoints and Tumor Metastasis.
Xi-Yang Tang, An-Ping Shi, +5 authors, Jin-Bo Zhao.
Front Oncol, 2021 Aug 10; 11. PMID: 34367975    Free PMC article.
Review.
Research status on immunotherapy trials of gastric cancer.
Chao Liang, Heng-Miao Wu, Wei-Ming Yu, Wei Chen.
World J Clin Cases, 2021 Aug 10; 9(21). PMID: 34368297    Free PMC article.
Review.
Prognostic and Predictive Impact of Circulating Tumor DNA in Patients with Advanced Cancers Treated with Immune Checkpoint Blockade.
Qu Zhang, Jia Luo, +12 authors, Matthew D Hellmann.
Cancer Discov, 2020 Aug 21; 10(12). PMID: 32816849    Free PMC article.
Characterization of neoantigen-specific T cells in cancer resistant to immune checkpoint therapies.
Shamin Li, Yannick Simoni, +10 authors, Evan W Newell.
Proc Natl Acad Sci U S A, 2021 Jul 22; 118(30). PMID: 34285073    Free PMC article.
Immune checkpoint blockade in renal cell carcinoma.
Phillip M Rappold, Andrew W Silagy, Ritesh R Kotecha, Ari A Hakimi.
J Surg Oncol, 2021 Feb 18; 123(3). PMID: 33595892    Free PMC article.
Review.
Post-transcriptional control of T-cell cytokine production: Implications for cancer therapy.
Julian J Freen-van Heeren.
Immunology, 2021 Apr 23; 164(1). PMID: 33884612    Free PMC article.
Review.
Enhancement of epidermal growth factor receptor antibody tumor immunotherapy by glutaminyl cyclase inhibition to interfere with CD47/signal regulatory protein alpha interactions.
Niklas Baumann, Thies Rösner, +12 authors, Thomas Valerius.
Cancer Sci, 2021 Jun 01; 112(8). PMID: 34058788    Free PMC article.
Characterization of Immune Checkpoint Inhibitor-Related Cardiotoxicity in Lung Cancer Patients From a Rural Setting.
Melissa Y Y Moey, Anna N Tomdio, +6 authors, Blase A Carabello.
JACC CardioOncol, 2021 Aug 17; 2(3). PMID: 34396256    Free PMC article.
Prevalence and risk factors for multimorbidity in older US patients with late-stage melanoma.
Pragya Rai, Chan Shen, +3 authors, Usha Sambamoorthi.
J Geriatr Oncol, 2020 Sep 30; 12(3). PMID: 32988783    Free PMC article.
Modified Glasgow Prognostic Score associated with survival in metastatic renal cell carcinoma treated with immune checkpoint inhibitors.
Jacqueline T Brown, Yuan Liu, +15 authors, Mehmet Asim Bilen.
J Immunother Cancer, 2021 Jul 31; 9(7). PMID: 34326170    Free PMC article.
Blockade of immune checkpoints in lymph nodes through locoregional delivery augments cancer immunotherapy.
David M Francis, Margaret P Manspeaker, +6 authors, Susan N Thomas.
Sci Transl Med, 2020 Oct 02; 12(563). PMID: 32998971    Free PMC article.
Technological advances in cancer immunity: from immunogenomics to single-cell analysis and artificial intelligence.
Ying Xu, Guan-Hua Su, +3 authors, Yi-Zhou Jiang.
Signal Transduct Target Ther, 2021 Aug 22; 6(1). PMID: 34417437    Free PMC article.
Review.
Novel insights on gut microbiota manipulation and immune checkpoint inhibition in cancer (Review).
Silvia Vivarelli, Luca Falzone, +2 authors, Massimo Libra.
Int J Oncol, 2021 Aug 17; 59(3). PMID: 34396439    Free PMC article.
Review.
p16INK4a Regulates Cellular Senescence in PD-1-Expressing Human T Cells.
Valérie Janelle, Mathieu Neault, +10 authors, Jean-Sébastien Delisle.
Front Immunol, 2021 Aug 27; 12. PMID: 34434190    Free PMC article.
Immune Checkpoint Inhibitors Mediated Lymphocytic and Giant Cell Myocarditis: Uncovering Etiological Mechanisms.
Rishi Rikhi, Jaret Karnuta, +5 authors, Rohit Moudgil.
Front Cardiovasc Med, 2021 Aug 27; 8. PMID: 34434981    Free PMC article.
Review.
Pancreatic Cancer and Immunotherapy: A Clinical Overview.
Florentine E F Timmer, Bart Geboers, +12 authors, Tanja D de Gruijl.
Cancers (Basel), 2021 Aug 28; 13(16). PMID: 34439292    Free PMC article.
Review.
Immune checkpoint inhibitor-mediated colitis in gastrointestinal malignancies and inflammatory bowel disease.
Alexa R Weingarden, Samuel J S Rubin, John Gubatan.
World J Gastrointest Oncol, 2021 Aug 31; 13(8). PMID: 34457186    Free PMC article.
Review.
Outcomes with durvalumab by tumour PD-L1 expression in unresectable, stage III non-small-cell lung cancer in the PACIFIC trial.
L Paz-Ares, A Spira, +18 authors, C Faivre-Finn.
Ann Oncol, 2020 Mar 27; 31(6). PMID: 32209338    Free PMC article.
Immunotherapy for HPV Malignancies.
Maxwell Y Lee, Clint T Allen.
Semin Radiat Oncol, 2021 Aug 31; 31(4). PMID: 34455991    Free PMC article.
Review.
Comparison of tumor mutation burden of 300 various non-Hodgkin lymphomas using panel based massively parallel sequencing.
Junhun Cho, Sang Eun Yoon, +2 authors, Won Seog Kim.
BMC Cancer, 2021 Sep 01; 21(1). PMID: 34461835    Free PMC article.
NKG2D defines tumor-reacting effector CD8+ T cells within tumor microenvironment.
Marija Mojic, Kiyomi Shitaoka, +6 authors, Yoshihiro Hayakawa.
Cancer Sci, 2021 Jun 30; 112(9). PMID: 34187084    Free PMC article.
Autophagy promotes growth of tumors with high mutational burden by inhibiting a T-cell immune response.
Laura Poillet-Perez, Daniel W Sharp, +15 authors, Eileen White.
Nat Cancer, 2021 Sep 04; 1(9). PMID: 34476408    Free PMC article.
Cytidine Deaminase APOBEC3A Regulates PD-L1 Expression in Cancer Cells in a JNK/c-JUN-Dependent Manner.
Kailiang Zhao, Qiang Zhang, +9 authors, Meredith A Morgan.
Mol Cancer Res, 2021 May 29; 19(9). PMID: 34045311    Free PMC article.
Identification of a Costimulatory Molecule-Related Signature for Predicting Prognostic Risk in Prostate Cancer.
Shengdong Ge, Xiaoliang Hua, +5 authors, Sheng Tai.
Front Genet, 2021 Sep 07; 12. PMID: 34484286    Free PMC article.
Current Status of Immune Checkpoint Inhibitor Immunotherapy for Lung Cancer.
Wei Xiong, Yunfeng Zhao, He Du, Xuejun Guo.
Front Oncol, 2021 Sep 08; 11. PMID: 34490104    Free PMC article.
Review.
Classification and Treatment of Diseases in the Age of Genome Medicine Based on Pathway Pathology.
Iver Petersen.
Int J Mol Sci, 2021 Sep 11; 22(17). PMID: 34502326    Free PMC article.
Review.
Intron retention-induced neoantigen load correlates with unfavorable prognosis in multiple myeloma.
Chuanpeng Dong, Annamaria Cesarano, +10 authors, Yunlong Liu.
Oncogene, 2021 Sep 11; 40(42). PMID: 34504297    Free PMC article.
DPYSL2 as potential diagnostic and prognostic biomarker linked to immune infiltration in lung adenocarcinoma.
Yang-Jie Wu, Ai-Tao Nai, +5 authors, Xiao-Hong Ai.
World J Surg Oncol, 2021 Sep 15; 19(1). PMID: 34517904    Free PMC article.
[The expression and prognostic value of PD-1, TIM-3, LAG-3 and BTLA in extranodal NK/T cell lymphoma].
L Nie, X Y Liu, +6 authors, Z M Zhu.
Zhonghua Xue Ye Xue Za Zhi, 2021 Aug 30; 42(7). PMID: 34455749    Free PMC article.
Structure-Based Discovery of Proline-Derived Arginase Inhibitors with Improved Oral Bioavailability for Immuno-Oncology.
Min Lu, Hongjun Zhang, +22 authors, Christian Fischer.
ACS Med Chem Lett, 2021 Sep 17; 12(9). PMID: 34527178    Free PMC article.
Stromal infiltrating mast cells identify immunoevasive subtype high-grade serous ovarian cancer with poor prognosis and inferior immunotherapeutic response.
Kankan Cao, Guodong Zhang, +5 authors, Haiou Liu.
Oncoimmunology, 2021 Sep 17; 10(1). PMID: 34527431    Free PMC article.
Dermatologic infections in cancer patients treated with checkpoint inhibitors.
Mytrang H Do, Dulce M Barrios, +6 authors, Mario E Lacouture.
J Am Acad Dermatol, 2021 Mar 22; 85(6). PMID: 33744355    Free PMC article.
Tumor NLRP3-Derived IL-1β Drives the IL-6/STAT3 Axis Resulting in Sustained MDSC-Mediated Immunosuppression.
Isak W Tengesdal, Alberto Dinarello, +4 authors, Charles A Dinarello.
Front Immunol, 2021 Sep 18; 12. PMID: 34531850    Free PMC article.
A costimulatory molecule-related signature in regard to evaluation of prognosis and immune features for clear cell renal cell carcinoma.
Xiaoliang Hua, Shengdong Ge, +5 authors, Chaozhao Liang.
Cell Death Discov, 2021 Sep 20; 7(1). PMID: 34537809    Free PMC article.
PD-1/PD-L1 Checkpoint Inhibitors in Tumor Immunotherapy.
Jinhua Liu, Zichao Chen, +3 authors, Zhen Zhang.
Front Pharmacol, 2021 Sep 21; 12. PMID: 34539412    Free PMC article.
Review.
Immune escape mechanisms and immunotherapy of urothelial bladder cancer.
Zhao Yang, Yinyan Xu, +16 authors, Changyuan Yu.
J Clin Transl Res, 2021 Sep 21; 7(4). PMID: 34541363    Free PMC article.
Review.
9p21 loss confers a cold tumor immune microenvironment and primary resistance to immune checkpoint therapy.
Guangchun Han, Guoliang Yang, +29 authors, Linghua Wang.
Nat Commun, 2021 Sep 25; 12(1). PMID: 34556668    Free PMC article.
Comprehensive Analysis of the Prognostic Value and Immune Function of Immune Checkpoints in Stomach Adenocarcinoma.
Kai Shen, Tong Liu.
Int J Gen Med, 2021 Sep 25; 14. PMID: 34557032    Free PMC article.
New Immunotherapeutic Approaches for Glioblastoma.
Gustavo Ignacio Vázquez Cervantes, Dinora F González Esquivel, +2 authors, Verónica Pérez de la Cruz.
J Immunol Res, 2021 Sep 25; 2021. PMID: 34557553    Free PMC article.
Review.
Sharpening up tumor microenvironment to enhance the efficacy of immune checkpoint blockade on head and neck cancer using a CpG-oligodeoxynucleotide.
Jen-Chih Tseng, Jing-Xing Yang, +7 authors, Tsung-Hsien Chuang.
Cancer Immunol Immunother, 2021 Sep 29; 71(5). PMID: 34581869    Free PMC article.
Immune gene therapy of cancer
Hakan Akbulut.
Turk J Med Sci, 2020 Jun 10; 50(SI-2). PMID: 32512674    Free PMC article.
Review.
Efficient killing of tumor cells by CAR-T cells requires greater number of engaged CARs than TCRs.
Nadia Anikeeva, Sergey Panteleev, +3 authors, Yuri Sykulev.
J Biol Chem, 2021 Aug 10; 297(3). PMID: 34371020    Free PMC article.
Functional Characterization of Pembrolizumab Produced in Nicotiana benthamiana Using a Rapid Transient Expression System.
Tanapati Phakham, Christine Joy I Bulaon, +9 authors, Waranyoo Phoolcharoen.
Front Plant Sci, 2021 Sep 28; 12. PMID: 34567049    Free PMC article.
Multi-Omics Analysis of the Anti-tumor Synergistic Mechanism and Potential Application of Immune Checkpoint Blockade Combined With Lenvatinib.
Yuting Lu, Jiangtao Jin, +5 authors, Qin Li.
Front Cell Dev Biol, 2021 Sep 28; 9. PMID: 34568339    Free PMC article.
Sialic Acid Ligands of CD28 Suppress Costimulation of T Cells.
Landon J Edgar, Andrew J Thompson, +4 authors, James C Paulson.
ACS Cent Sci, 2021 Sep 30; 7(9). PMID: 34584952    Free PMC article.
The Potential of Tissue-Resident Memory T Cells for Adoptive Immunotherapy against Cancer.
Ammarina Beumer-Chuwonpad, Renske L R E Taggenbrock, T An Ngo, Klaas P J M van Gisbergen.
Cells, 2021 Sep 29; 10(9). PMID: 34571883    Free PMC article.
Review.
Epitranscriptomic Approach: To Improve the Efficacy of ICB Therapy by Co-Targeting Intracellular Checkpoint CISH.
Sunil Kumar, Parth Sarthi, +4 authors, Yong-Soo Bae.
Cells, 2021 Sep 29; 10(9). PMID: 34571899    Free PMC article.
Review.
Current Immunotherapeutic Strategies for the Treatment of Glioblastoma.
Mark Dapash, Brandyn Castro, David Hou, Catalina Lee-Chang.
Cancers (Basel), 2021 Sep 29; 13(18). PMID: 34572775    Free PMC article.
Review.
Integrating Cancer Vaccines in the Standard-of-Care of Ovarian Cancer: Translating Preclinical Models to Human.
Cheryl Lai-Lai Chiang, Raphaël Rovelli, Apostolos Sarivalasis, Lana E Kandalaft.
Cancers (Basel), 2021 Sep 29; 13(18). PMID: 34572778    Free PMC article.
Review.
Motility Dynamics of T Cells in Tumor-Draining Lymph Nodes: A Rational Indicator of Antitumor Response and Immune Checkpoint Blockade.
Yasuhiro Kanda, Taku Okazaki, Tomoya Katakai.
Cancers (Basel), 2021 Sep 29; 13(18). PMID: 34572844    Free PMC article.
Review.
Inhibiting the Unconventionals: Importance of Immune Checkpoint Receptors in γδ T, MAIT, and NKT Cells.
Elisa Catafal-Tardos, Maria Virginia Baglioni, Vasileios Bekiaris.
Cancers (Basel), 2021 Sep 29; 13(18). PMID: 34572874    Free PMC article.
Review.
The PD-1/PD-L1 Checkpoint in Normal Germinal Centers and Diffuse Large B-Cell Lymphomas.
Marcos Garcia-Lacarte, Sara C Grijalba, +2 authors, Sergio Roa.
Cancers (Basel), 2021 Sep 29; 13(18). PMID: 34572910    Free PMC article.
Review.
How Immunotherapy Has Changed the Continuum of Care in Hepatocellular Carcinoma.
Giulia Martini, Davide Ciardiello, +12 authors, Erika Martinelli.
Cancers (Basel), 2021 Sep 29; 13(18). PMID: 34572944    Free PMC article.
Review.
Deciphering Repertoire of B16 Melanoma Reactive TCRs by Immunization, In Vitro Restimulation and Sequencing of IFNγ-Secreting T Cells.
Anna V Izosimova, Diana V Yuzhakova, +4 authors, George V Sharonov.
Int J Mol Sci, 2021 Sep 29; 22(18). PMID: 34576023    Free PMC article.
In Situ Cancer Vaccination and Immunovirotherapy Using Oncolytic HSV.
Nusrat Jahan, Shanawaz M Ghouse, Robert L Martuza, Samuel D Rabkin.
Viruses, 2021 Sep 29; 13(9). PMID: 34578321    Free PMC article.
Review.
An Indirect Comparison Between Nivolumab + Ipilimumab + Two Cycles of Chemotherapy vs. Pembrolizumab + Chemotherapy as First-Line Treatment for Metastatic Non-Small Cell Lung Cancer.
Panpan Jiang, Ziyang Mao, +7 authors, Hui Guo.
Front Oncol, 2021 Oct 01; 11. PMID: 34589422    Free PMC article.
Systematic Review.
Short Review on Advances in Hydrogel-Based Drug Delivery Strategies for Cancer Immunotherapy.
Hee Seung Seo, Chi-Pin James Wang, Wooram Park, Chun Gwon Park.
Tissue Eng Regen Med, 2021 Oct 02; 19(2). PMID: 34596839    Free PMC article.
Review.
Targeting the spectrum of immune checkpoints in prostate cancer.
Laura A Sena, Samuel R Denmeade, Emmanuel S Antonarakis.
Expert Rev Clin Pharmacol, 2021 Jul 16; 14(10). PMID: 34263692    Free PMC article.
Review.
Impact of Anti-PD-1 and Anti-CTLA-4 on the Human Immunodeficiency Virus (HIV) Reservoir in People Living With HIV With Cancer on Antiretroviral Therapy: The AIDS Malignancy Consortium 095 Study.
Thomas A Rasmussen, Lakshmi Rajdev, +16 authors, Sharon R Lewin.
Clin Infect Dis, 2021 Mar 08; 73(7). PMID: 33677480    Free PMC article.
Effects of combination treatment with durvalumab plus tremelimumab on the tumor microenvironment in non-small-cell lung carcinoma.
Li Cheng, Todd Creasy, +4 authors, Katie Streicher.
Cancer Immunol Immunother, 2021 Oct 09; 71(5). PMID: 34623465    Free PMC article.
Tumour-intrinsic resistance to immune checkpoint blockade.
Anusha Kalbasi, Antoni Ribas.
Nat Rev Immunol, 2019 Oct 02; 20(1). PMID: 31570880    Free PMC article.
Highly Cited. Review.
Characterizing the function of domain linkers in regulating the dynamics of multi-domain fusion proteins by microsecond molecular dynamics simulations and artificial intelligence.
Bo Wang, Zhaoqian Su, Yinghao Wu.
Proteins, 2021 Feb 24; 89(7). PMID: 33620752    Free PMC article.
Elevated T cell repertoire diversity is associated with progression of lung squamous cell premalignant lesions.
Asaf Maoz, Carter Merenstein, +12 authors, Jennifer Beane.
J Immunother Cancer, 2021 Sep 29; 9(9). PMID: 34580161    Free PMC article.
First-line nivolumab plus ipilimumab with two cycles of chemotherapy versus chemotherapy alone (four cycles) in advanced non-small-cell lung cancer: CheckMate 9LA 2-year update.
M Reck, T-E Ciuleanu, +24 authors, T John.
ESMO Open, 2021 Oct 05; 6(5). PMID: 34607285    Free PMC article.
Low Soluble Programmed Cell Death Protein 1 Levels After Allogeneic Stem Cell Transplantation Predict Moderate or Severe Chronic GvHD and Inferior Overall Survival.
Lambros Kordelas, Ulrike Buttkereit, +5 authors, Vera Rebmann.
Front Immunol, 2021 Oct 12; 12. PMID: 34630383    Free PMC article.
The Multifaceted Role of Regulatory T Cells in Breast Cancer.
Kevin Kos, Karin E de Visser.
Annu Rev Cancer Biol, 2021 Oct 12; 5. PMID: 34632244    Free PMC article.
Embracing nanomaterials' interactions with the innate immune system.
Abraham J P Teunissen, Marianne E Burnett, +3 authors, Willem J M Mulder.
Wiley Interdiscip Rev Nanomed Nanobiotechnol, 2021 Apr 14; 13(6). PMID: 33847441    Free PMC article.
Review.
Cardiac Toxicity Associated with Cancer Immunotherapy and Biological Drugs.
Andrea Montisci, Maria Teresa Vietri, +3 authors, Claudio Napoli.
Cancers (Basel), 2021 Oct 14; 13(19). PMID: 34638281    Free PMC article.
Review.
At the Cutting Edge against Cancer: A Perspective on Immunoproteasome and Immune Checkpoints Modulation as a Potential Therapeutic Intervention.
Grazia R Tundo, Diego Sbardella, +5 authors, Stefano Marini.
Cancers (Basel), 2021 Oct 14; 13(19). PMID: 34638337    Free PMC article.
Review.
Ubiquitination in T-Cell Activation and Checkpoint Inhibition: New Avenues for Targeted Cancer Immunotherapy.
Shubhangi Gavali, Jianing Liu, Xinyi Li, Magdalena Paolino.
Int J Mol Sci, 2021 Oct 14; 22(19). PMID: 34639141    Free PMC article.
Review.
Trough levels of ipilimumab in serum as a potential biomarker of clinical outcomes for patients with advanced melanoma after treatment with ipilimumab.
Yoshinobu Koguchi, Noriko Iwamoto, +6 authors, William L Redmond.
J Immunother Cancer, 2021 Oct 09; 9(10). PMID: 34620702    Free PMC article.
Pulmonary Toxicities Associated With the Use of Immune Checkpoint Inhibitors: An Update From the Immuno-Oncology Subgroup of the Neutropenia, Infection & Myelosuppression Study Group of the Multinational Association for Supportive Care in Cancer.
Bernardo L Rapoport, Vickie R Shannon, +5 authors, Ronald Anderson.
Front Pharmacol, 2021 Oct 23; 12. PMID: 34675810    Free PMC article.
Review.
Cowpea mosaic virus stimulates antitumor immunity through recognition by multiple MYD88-dependent toll-like receptors.
Chenkai Mao, Veronique Beiss, +2 authors, Steven Fiering.
Biomaterials, 2021 Jun 15; 275. PMID: 34126409    Free PMC article.
Emerging Landscape of Immunotherapy for Primary Central Nervous System Lymphoma.
Marion Alcantara, Jaime Fuentealba, Carole Soussain.
Cancers (Basel), 2021 Oct 24; 13(20). PMID: 34680209    Free PMC article.
Review.
Overcoming Resistance to Immunotherapy in Advanced Cutaneous Squamous Cell Carcinoma.
Natalia García-Sancha, Roberto Corchado-Cobos, +5 authors, Javier Cañueto.
Cancers (Basel), 2021 Oct 24; 13(20). PMID: 34680282    Free PMC article.
Review.
PD-L1 immunostaining: what pathologists need to know.
Mohammed Akhtar, Sameera Rashid, Issam A Al-Bozom.
Diagn Pathol, 2021 Oct 26; 16(1). PMID: 34689789    Free PMC article.
Review.
CD8+ T cell metabolism in infection and cancer.
Miguel Reina-Campos, Nicole E Scharping, Ananda W Goldrath.
Nat Rev Immunol, 2021 May 14; 21(11). PMID: 33981085    Free PMC article.
Review.
Sorting nexin 6 interacts with Cullin3 and regulates programmed death ligand 1 expression.
Chinmoy Ghosh, Yanli Xing, +4 authors, Yue Sun.
FEBS Lett, 2021 Sep 13; 595(20). PMID: 34510437    Free PMC article.
Efficacy and safety of immune checkpoint inhibitors in elderly patients with metastatic renal cell carcinoma.
Yuki Nemoto, Hiroki Ishihara, +10 authors, Toshio Takagi.
Int Urol Nephrol, 2021 Oct 28; 54(1). PMID: 34704214
Modulating expression of inhibitory and stimulatory immune 'checkpoints' using nanoparticulate-assisted nucleic acid delivery.
Adam A Walters, Baljevan Dhadwar, Khuloud T Al-Jamal.
EBioMedicine, 2021 Oct 24; 73. PMID: 34688033    Free PMC article.
Review.
Interrogation of the Microenvironmental Landscape in Brain Tumors Reveals Disease-Specific Alterations of Immune Cells.
Florian Klemm, Roeltje R Maas, +11 authors, Johanna A Joyce.
Cell, 2020 May 30; 181(7). PMID: 32470396    Free PMC article.
Application of immune checkpoint targets in the anti-tumor novel drugs and traditional Chinese medicine development.
Yuli Wang, Xingyan Zhang, +8 authors, Changxiao Liu.
Acta Pharm Sin B, 2021 Nov 04; 11(10). PMID: 34729298    Free PMC article.
Review.
Gut Microbiota for Esophageal Cancer: Role in Carcinogenesis and Clinical Implications.
Jianfeng Zhou, Shangwei Sun, +7 authors, Yong Yuan.
Front Oncol, 2021 Nov 05; 11. PMID: 34733778    Free PMC article.
Review.
Cautious addition of targeted therapy to PD-1 inhibitors after initial progression of BRAF mutant metastatic melanoma on checkpoint inhibitor therapy.
Wolfram Samlowski, Camille Adajar.
BMC Cancer, 2021 Nov 09; 21(1). PMID: 34743688    Free PMC article.
Immunotherapies for hepatocellular carcinoma.
Josep M Llovet, Florian Castet, +6 authors, Richard S Finn.
Nat Rev Clin Oncol, 2021 Nov 13; 19(3). PMID: 34764464
Review.
Tumor-immune profiling of CT-26 and Colon 26 syngeneic mouse models reveals mechanism of anti-PD-1 response.
Yosuke Sato, Yu Fu, +2 authors, Michael H Shaw.
BMC Cancer, 2021 Nov 15; 21(1). PMID: 34774008    Free PMC article.
Synergy between Toxoplasma gondii type I ΔGRA17 immunotherapy and PD-L1 checkpoint inhibition triggers the regression of targeted and distal tumors.
Yu-Chao Zhu, Hany M Elsheikha, +4 authors, Jia Chen.
J Immunother Cancer, 2021 Nov 03; 9(11). PMID: 34725213    Free PMC article.
Development of a nanobody-based immunoassay for the sensitive detection of fibrinogen-like protein 1.
Wan-Ting Zhang, Ting-Ting Liu, +9 authors, Yong Geng.
Acta Pharmacol Sin, 2021 Feb 27; 42(11). PMID: 33633363    Free PMC article.
Regulation of the innate immune cells during pregnancy: An immune checkpoint perspective.
Wen-Xuan Li, Xiang-Hong Xu, Li-Ping Jin.
J Cell Mol Med, 2021 Oct 29; 25(22). PMID: 34708495    Free PMC article.
Review.
Updates on Molecular and Biochemical Development and Progression of Prostate Cancer.
Omar Fahmy, Nabil A Alhakamy, +9 authors, Giuseppe Caruso.
J Clin Med, 2021 Nov 14; 10(21). PMID: 34768647    Free PMC article.
Review.
IL-10 Signaling Elicited by Nivolumab-Induced Activation of the MAP Kinase Pathway Does Not Fully Contribute to Nivolumab-Modulated Heterogeneous T Cell Responses.
Taylor A Harper, Silvia M Bacot, +10 authors, Gerald M Feldman.
Int J Mol Sci, 2021 Nov 14; 22(21). PMID: 34769278    Free PMC article.
Cure the Incurable? Recent Breakthroughs in Immune Checkpoint Blockade for Hepatocellular Carcinoma.
Pei-Yi Chu, Shih-Hsuan Chan.
Cancers (Basel), 2021 Nov 14; 13(21). PMID: 34771459    Free PMC article.
Review.
Immunotherapy in Medulloblastoma: Current State of Research, Challenges, and Future Perspectives.
Marije J Voskamp, Shuang Li, +3 authors, Niels Bovenschen.
Cancers (Basel), 2021 Nov 14; 13(21). PMID: 34771550    Free PMC article.
Review.
Metronomic Anti-Cancer Therapy: A Multimodal Therapy Governed by the Tumor Microenvironment.
Raquel Muñoz, Alessandra Girotti, Denise Hileeto, Francisco Javier Arias.
Cancers (Basel), 2021 Nov 14; 13(21). PMID: 34771577    Free PMC article.
Review.
Mycobacterium tuberculosis Rv3628 isan effective adjuvant via activationof dendritic cells for cancer immunotherapy.
Juan Wu, Heng Yang, +7 authors, Xiao-Yong Fan.
Mol Ther Oncolytics, 2021 Nov 18; 23. PMID: 34786473    Free PMC article.
WEE1 inhibitor and ataxia telangiectasia and RAD3-related inhibitor trigger stimulator of interferon gene-dependent immune response and enhance tumor treatment efficacy through programmed death-ligand 1 blockade.
Xue Wu, Xiaoyan Kang, +12 authors, Changyu Wang.
Cancer Sci, 2021 Aug 13; 112(11). PMID: 34382294    Free PMC article.
Biological Bases of Immune-Related Adverse Events and Potential Crosslinks With Immunogenic Effects of Radiation.
Lilia Bardoscia, Nadia Pasinetti, +2 authors, Angela Sardaro.
Front Pharmacol, 2021 Nov 19; 12. PMID: 34790123    Free PMC article.
Review.
Conventional type I dendritic cells maintain a reservoir of proliferative tumor-antigen specific TCF-1+ CD8+ T cells in tumor-draining lymph nodes.
Jason M Schenkel, Rebecca H Herbst, +19 authors, Tyler Jacks.
Immunity, 2021 Sep 18; 54(10). PMID: 34534439    Free PMC article.
Dendritic Cell Vaccination of Glioblastoma: Road to Success or Dead End.
Angeliki Datsi, Rüdiger V Sorg.
Front Immunol, 2021 Nov 20; 12. PMID: 34795675    Free PMC article.
Review.
Determinants of anti-PD-1 response and resistance in clear cell renal cell carcinoma.
Lewis Au, Emine Hatipoglu, +55 authors, TRACERx Renal Consortium.
Cancer Cell, 2021 Oct 30; 39(11). PMID: 34715028    Free PMC article.
Atezolizumab-Induced Hypothyroidism in a Patient With Pre-existing Triiodothyronine (T3) Thyrotoxicosis Due to Graves' Disease: A Case Report and Literature Review.
Samson O Oyibo, Mohamed O Mahgoub.
Cureus, 2021 Nov 24; 13(11). PMID: 34812334    Free PMC article.
A high OXPHOS CD8 T cell subset is predictive of immunotherapy resistance in melanoma patients.
Chuan Li, Yee Peng Phoon, +19 authors, Brian R Gastman.
J Exp Med, 2021 Nov 23; 219(1). PMID: 34807232    Free PMC article.
Neoadjuvant PD-1 blockade induces T cell and cDC1 activation but fails to overcome the immunosuppressive tumor associated macrophages in recurrent glioblastoma.
Alexander H Lee, Lu Sun, +11 authors, Robert M Prins.
Nat Commun, 2021 Nov 28; 12(1). PMID: 34836966    Free PMC article.
Characterization of a library of 20 HBV-specific MHC class II-restricted T cell receptors.
Sophia Schreiber, Melanie Honz, +8 authors, Karin Wisskirchen.
Mol Ther Methods Clin Dev, 2021 Dec 03; 23. PMID: 34853796    Free PMC article.
Role of Immune Checkpoint Inhibitor Therapy in Advanced EGFR-Mutant Non-Small Cell Lung Cancer.
Nathaniel Wiest, Umair Majeed, +3 authors, Rami Manochakian.
Front Oncol, 2021 Dec 07; 11. PMID: 34868953    Free PMC article.
Review.
Bioinformatic Analysis of Immune Significance of RYR2 Mutation in Breast Cancer.
Zhiquan Xu, Ling Xiang, +5 authors, Linglong Peng.
Biomed Res Int, 2021 Dec 11; 2021. PMID: 34888385    Free PMC article.
DISE/6mer seed toxicity-a powerful anti-cancer mechanism with implications for other diseases.
Ashley Haluck-Kangas, Monal Patel, +3 authors, Marcus E Peter.
J Exp Clin Cancer Res, 2021 Dec 12; 40(1). PMID: 34893072    Free PMC article.
Review.
Bayesian Networks to Support Decision-Making for Immune-Checkpoint Blockade in Recurrent/Metastatic (R/M) Head and Neck Squamous Cell Carcinoma (HNSCC).
Marius Huehn, Jan Gaebel, +4 authors, Matthaeus Stoehr.
Cancers (Basel), 2021 Dec 11; 13(23). PMID: 34884998    Free PMC article.
Directing the Future Breakthroughs in Immunotherapy: The Importance of a Holistic Approach to the Tumour Microenvironment.
Hannah V Newnes, Jesse D Armitage, +2 authors, Jason Waithman.
Cancers (Basel), 2021 Dec 11; 13(23). PMID: 34885021    Free PMC article.
Review.
Magnetic nanoparticles in theranostics of malignant melanoma.
Maxim Shevtsov, Susanne Kaesler, +2 authors, Tilo Biedermann.
EJNMMI Res, 2021 Dec 15; 11(1). PMID: 34905138    Free PMC article.
Review.
A Novel Immune-Gene Pair Signature Revealing the Tumor Microenvironment Features and Immunotherapy Prognosis of Muscle-Invasive Bladder Cancer.
Xiaonan Zheng, Xianghong Zhou, +6 authors, Qiang Wei.
Front Genet, 2021 Dec 14; 12. PMID: 34899849    Free PMC article.
The Price of Success: Immune-Related Adverse Events from Immunotherapy in Lung Cancer.
Courtney H Coschi, Rosalyn A Juergens.
Curr Oncol, 2021 Dec 14; 28(6). PMID: 34898551    Free PMC article.
Review.
Identification of a Novel Stem Cell Subtype for Clear Cell Renal Cell Carcinoma Based on Stem Cell Gene Profiling.
Hongzhi Wang, Hanjiang Xu, Quan Cheng, Chaozhao Liang.
Front Oncol, 2021 Dec 17; 11. PMID: 34912710    Free PMC article.
Potential Immune Biomarker Candidates and Immune Subtypes of Lung Adenocarcinoma for Developing mRNA Vaccines.
Yang Wang, Huaicheng Tan, +3 authors, Huashan Shi.
Front Immunol, 2021 Dec 18; 12. PMID: 34917077    Free PMC article.
The foundations of immune checkpoint blockade and the ipilimumab approval decennial.
Alan J Korman, Sarah C Garrett-Thomson, Nils Lonberg.
Nat Rev Drug Discov, 2021 Dec 24;. PMID: 34937915
Review.
Current development in adenoviral vectors for cancer immunotherapy.
Greyson Willis Grossman Biegert, Amanda Rosewell Shaw, Masataka Suzuki.
Mol Ther Oncolytics, 2021 Dec 24; 23. PMID: 34938857    Free PMC article.
Review.
Laser nanobubbles induce immunogenic cell death in breast cancer.
Hieu T M Nguyen, Nitesh Katta, +8 authors, James W Tunnell.
Nanoscale, 2021 Feb 05; 13(6). PMID: 33538275    Free PMC article.
Our current understanding of checkpoint inhibitor therapy in cancer immunotherapy.
Elena Goleva, Taras Lyubchenko, +3 authors, Jeffrey A Kern.
Ann Allergy Asthma Immunol, 2021 Mar 16; 126(6). PMID: 33716146    Free PMC article.
Review.
Distinct exhaustion features of T lymphocytes shape the tumor-immune microenvironment with therapeutic implication in patients with non-small-cell lung cancer.
Chang Gon Kim, Gamin Kim, +8 authors, Hye Ryun Kim.
J Immunother Cancer, 2021 Dec 16; 9(12). PMID: 34907028    Free PMC article.
Roles of tumor-associated macrophages in tumor progression: implications on therapeutic strategies.
Shuangli Zhu, Ming Yi, +2 authors, Kongming Wu.
Exp Hematol Oncol, 2021 Dec 31; 10(1). PMID: 34965886    Free PMC article.
Review.
Protein-Based Nanoparticles for the Imaging and Treatment of Solid Tumors: The Case of Ferritin Nanocages, a Narrative Review.
Francesco Mainini, Arianna Bonizzi, +4 authors, Serena Mazzucchelli.
Pharmaceutics, 2021 Dec 29; 13(12). PMID: 34959283    Free PMC article.
Review.
Development and Clinical Validation of Novel 8-Gene Prognostic Signature Associated With the Proportion of Regulatory T Cells by Weighted Gene Co-Expression Network Analysis in Uterine Corpus Endometrial Carcinoma.
Jinhui Liu, Rui Geng, +6 authors, Jianling Bai.
Front Immunol, 2022 Jan 01; 12. PMID: 34970268    Free PMC article.
Function and Molecular Mechanism of the DNA Damage Response in Immunity and Cancer Immunotherapy.
Zu Ye, Yin Shi, Susan P Lees-Miller, John A Tainer.
Front Immunol, 2022 Jan 01; 12. PMID: 34970273    Free PMC article.
Review.
GDPLichi: a DNA Damage Repair-Related Gene Classifier for Predicting Lung Adenocarcinoma Immune Checkpoint Inhibitors Response.
Yang Leng, Shiying Dang, +14 authors, Bihui Huang.
Front Oncol, 2022 Jan 01; 11. PMID: 34970479    Free PMC article.
Immunotherapy in Lung Cancer: Are the Promises of Long-Term Benefit Finally Met?
Diego L Kaen, Nicolas Minatta, +3 authors, Christian Rolfo.
Adv Exp Med Biol, 2022 Jan 02; 1342. PMID: 34972964
Review.
Phase I Clinical Trial of an Autologous Dendritic Cell Vaccine Against HER2 Shows Safety and Preliminary Clinical Efficacy.
Hoyoung M Maeng, Brittni N Moore, +18 authors, Jay A Berzofsky.
Front Oncol, 2022 Jan 04; 11. PMID: 34976830    Free PMC article.
Emerging biomaterial-based strategies for personalized therapeutic in situ cancer vaccines.
Dixita Ishani Viswanath, Hsuan-Chen Liu, +2 authors, Alessandro Grattoni.
Biomaterials, 2021 Dec 14; 280. PMID: 34902729    Free PMC article.
Review.
Determinants of survival in advanced non-small cell lung cancer patients treated with anti-PD-1/PD-L1 therapy.
Wael Abdullah Sultan Ali, Pan Hui, +10 authors, Li Zhang.
Ann Transl Med, 2022 Jan 07; 9(22). PMID: 34988148    Free PMC article.
Plexin-A4 Mediates Cytotoxic T-cell Trafficking and Exclusion in Cancer.
Ward Celus, Ana I Oliveira, +15 authors, Massimiliano Mazzone.
Cancer Immunol Res, 2021 Nov 25; 10(1). PMID: 34815265    Free PMC article.
Safety and efficacy of dendritic cell-based immunotherapy (DCVAC/LuCa) combined with carboplatin/pemetrexed for patients with advanced non-squamous non-small-cell lung cancer without oncogenic drivers.
R Zhong, X Ling, +6 authors, H Zhong.
ESMO Open, 2021 Dec 28; 7(1). PMID: 34959168    Free PMC article.
CTLA4-Mediated Immunosuppression in Glioblastoma is Associated with the Infiltration of Macrophages in the Tumor Microenvironment.
Xiudong Guan, Yangyang Wang, +5 authors, Wang Jia.
J Inflamm Res, 2022 Jan 08; 14. PMID: 34992419    Free PMC article.
MAP3K8 Is a Prognostic Biomarker and Correlated With Immune Response in Glioma.
Jing Ren, Yixin Xu, +4 authors, Jinmin Sun.
Front Mol Biosci, 2022 Jan 11; 8. PMID: 35004849    Free PMC article.
Tumor-Associated Regulatory T Cell Expression of LAIR2 Is Prognostic in Lung Adenocarcinoma.
Dalam Ly, Quan Li, +6 authors, Li Zhang.
Cancers (Basel), 2022 Jan 12; 14(1). PMID: 35008369    Free PMC article.
Circular RNA hsa_circ_0000190 Facilitates the Tumorigenesis and Immune Evasion by Upregulating the Expression of Soluble PD-L1 in Non-Small-Cell Lung Cancer.
Yung-Hung Luo, Yi-Ping Yang, +8 authors, Shih-Hwa Chiou.
Int J Mol Sci, 2022 Jan 12; 23(1). PMID: 35008490    Free PMC article.
The Impact of the Microbiome on Resistance to Cancer Treatment with Chemotherapeutic Agents and Immunotherapy.
Aneta Sevcikova, Nikola Izoldova, +4 authors, Michal Mego.
Int J Mol Sci, 2022 Jan 12; 23(1). PMID: 35008915    Free PMC article.
Review.
Insights into Modern Therapeutic Approaches in Pediatric Acute Leukemias.
Kinga Panuciak, Mikołaj Margas, Karolina Makowska, Monika Lejman.
Cells, 2022 Jan 12; 11(1). PMID: 35011701    Free PMC article.
Review.
Predicting treatment outcomes using 18F-FDG PET biomarkers in patients with non-small-cell lung cancer receiving chemoimmunotherapy.
Chang Gon Kim, Sang Hyun Hwang, +10 authors, Sun Min Lim.
Ther Adv Med Oncol, 2022 Jan 18; 14. PMID: 35035536    Free PMC article.
Predictive molecular markers for the treatment with immune checkpoint inhibitors in colorectal cancer.
Fenqi Du, Yanlong Liu.
J Clin Lab Anal, 2021 Nov 25; 36(1). PMID: 34817097    Free PMC article.
Review.
Identification and Validation of Angiogenesis-Related Gene Expression for Predicting Prognosis in Patients With Ovarian Cancer.
Yue Wang, Bao Xuan Li, Xiang Li.
Front Oncol, 2022 Jan 21; 11. PMID: 35047401    Free PMC article.
Pembrolizumab and decitabine for refractory or relapsed acute myeloid leukemia.
Meghali Goswami, Gege Gui, +19 authors, Christopher S Hourigan.
J Immunother Cancer, 2022 Jan 13; 10(1). PMID: 35017151    Free PMC article.
Macrophages as a Therapeutic Target in Metastatic Prostate Cancer: A Way to Overcome Immunotherapy Resistance?
Clara Martori, Lidia Sanchez-Moral, +4 authors, Maria-Rosa Sarrias.
Cancers (Basel), 2022 Jan 22; 14(2). PMID: 35053602    Free PMC article.
Review.
Immunotherapy for Biliary Tract Cancer in the Era of Precision Medicine: Current Knowledge and Future Perspectives.
Davide Ciardiello, Brigida Anna Maiorano, +11 authors, Evaristo Maiello.
Int J Mol Sci, 2022 Jan 22; 23(2). PMID: 35055006    Free PMC article.
Review.
Back to the Future: Spatiotemporal Determinants of NK Cell Antitumor Function.
Joey H Li, Timothy E O'Sullivan.
Front Immunol, 2022 Jan 28; 12. PMID: 35082797    Free PMC article.
Review.
Developing and characterizing a single-domain antibody (nanobody) against human cytotoxic T-lymphocyte-associated protein 4 (hCTLA-4).
Nazli Sotoudeh, Zahra Noormohammadi, +2 authors, Mahdi Behdani.
Iran J Basic Med Sci, 2022 Jan 28; 24(9). PMID: 35083014    Free PMC article.
Tumor-Infiltrating Lymphocytes in Colorectal Cancer: The Fundamental Indication and Application on Immunotherapy.
Ziyi Bai, Yao Zhou, +3 authors, Feng Wang.
Front Immunol, 2022 Feb 01; 12. PMID: 35095898    Free PMC article.
Review.
Infiltrating T-cell abundance combined with EMT-related gene expression as a prognostic factor of colon cancer.
Xiaowei Huang, Chan Chen, +3 authors, Huafang Su.
Bioengineered, 2021 Jun 29; 12(1). PMID: 34180352    Free PMC article.
Harder, better, faster, stronger: biochemistry and biophysics in the immunosurveillance concert.
Maria Tello-Lafoz, Miguel M de Jesus, Morgan Huse.
Trends Immunol, 2022 Jan 03; 43(2). PMID: 34973924    Free PMC article.
Review.
Immune Checkpoint LAG3 and Its Ligand FGL1 in Cancer.
An-Ping Shi, Xi-Yang Tang, +7 authors, Jin-Bo Zhao.
Front Immunol, 2022 Feb 04; 12. PMID: 35111155    Free PMC article.
Review.
Vectorized Treg-depleting αCTLA-4 elicits antigen cross-presentation and CD8+ T cell immunity to reject 'cold' tumors.
Monika Semmrich, Jean-Baptiste Marchand, +15 authors, Björn Frendéus.
J Immunother Cancer, 2022 Jan 22; 10(1). PMID: 35058324    Free PMC article.
Systemic Immune Dysregulation Correlates With Clinical Features of Early Non-Small Cell Lung Cancer.
Zhixing Hao, Mingjie Lin, +11 authors, Pin Wu.
Front Immunol, 2022 Feb 05; 12. PMID: 35116020    Free PMC article.
Geographic heterogeneity in the outcomes of patients receiving immune checkpoint inhibitors for advanced solid tumors: a meta-analysis.
Manyu Li, Jiannan Yao, +2 authors, Guangyu An.
Transl Cancer Res, 2022 Feb 05; 10(1). PMID: 35116262    Free PMC article.
Clinicopathological implications of lncRNAs, immunotherapy and DNA methylation in lung squamous cell carcinoma: a narrative review.
Gabriel B K Sasa, Cheng Xuan, +2 authors, Xianfeng Ding.
Transl Cancer Res, 2022 Feb 05; 10(12). PMID: 35116387    Free PMC article.
Review.
A pan-cancer study of PD-1 and CTLA-4 as therapeutic targets.
Zongqiang Cai, Xiaojie Ang, +4 authors, Feng Zhou.
Transl Cancer Res, 2022 Feb 05; 10(9). PMID: 35116697    Free PMC article.
Potential therapies for immune-related adverse events associated with immune checkpoint inhibition: from monoclonal antibodies to kinase inhibition.
Meagan-Helen Henderson Berg, Sonia Victoria Del Rincón, Wilson H Miller.
J Immunother Cancer, 2022 Jan 29; 10(1). PMID: 35086945    Free PMC article.
Review.
Identification of the Association Between Toll-Like Receptors and T-Cell Activation in Takayasu's Arteritis.
Yixiao Tian, Biqing Huang, +2 authors, Xiaofeng Zeng.
Front Immunol, 2022 Feb 08; 12. PMID: 35126357    Free PMC article.
A cyclodextrin-based nanoformulation achieves co-delivery of ginsenoside Rg3 and quercetin for chemo-immunotherapy in colorectal cancer.
Dandan Sun, Yifang Zou, +8 authors, Jianfeng Guo.
Acta Pharm Sin B, 2022 Feb 08; 12(1). PMID: 35127393    Free PMC article.
Systematic Elucidation of the Aneuploidy Landscape and Identification of Aneuploidy Driver Genes in Prostate Cancer.
Yun Peng, Yuxuan Song, Haitao Wang.
Front Cell Dev Biol, 2022 Feb 08; 9. PMID: 35127694    Free PMC article.
Mechanisms regulating PD-L1 expression in cancers and associated opportunities for novel small-molecule therapeutics.
Hirohito Yamaguchi, Jung-Mao Hsu, Wen-Hao Yang, Mien-Chie Hung.
Nat Rev Clin Oncol, 2022 Feb 09; 19(5). PMID: 35132224
Review.
Immunotherapies for hepatocellular carcinoma.
Justin K H Liu, Andrew F Irvine, Rebecca L Jones, Adel Samson.
Cancer Med, 2021 Dec 26; 11(3). PMID: 34953051    Free PMC article.
Review.
PD-L1 signaling in reactive astrocytes counteracts neuroinflammation and ameliorates neuronal damage after traumatic brain injury.
Xiang Gao, Wei Li, +3 authors, Qigui Yu.
J Neuroinflammation, 2022 Feb 10; 19(1). PMID: 35135580    Free PMC article.
Glial Fibrillary Acidic Protein Autoimmunity: A French Cohort Study.
Alice Gravier-Dumonceau, Roxana Ameli, +44 authors, Romain Marignier.
Neurology, 2021 Nov 21; 98(6). PMID: 34799461    Free PMC article.
Prognostic significance and therapeutic potentials of immune checkpoints in osteosarcoma.
Vafa Meftahpour, Ali Aghebati-Maleki, +2 authors, Leili Aghebati-Maleki.
EXCLI J, 2022 Feb 12; 21. PMID: 35145371    Free PMC article.
Review.
A Novel Immune-Related ceRNA Network and Relative Potential Therapeutic Drug Prediction in ccRCC.
Weiquan Li, Xiangui Meng, +2 authors, Xiaoping Zhang.
Front Genet, 2022 Feb 12; 12. PMID: 35145542    Free PMC article.
Recent insights into the use of immune checkpoint inhibitors in gastric cancer.
Soraia Rodrigues, Ceu Figueiredo.
Porto Biomed J, 2022 Feb 12; 7(1). PMID: 35146175    Free PMC article.
Review.
Raman Spectroscopy and Machine Learning Reveals Early Tumor Microenvironmental Changes Induced by Immunotherapy.
Santosh Kumar Paidi, Joel Rodriguez Troncoso, +10 authors, Ishan Barman.
Cancer Res, 2021 Oct 15; 81(22). PMID: 34645610    Free PMC article.
Perioperative nivolumab monotherapy versus nivolumab plus ipilimumab in resectable hepatocellular carcinoma: a randomised, open-label, phase 2 trial.
Ahmed Omar Kaseb, Elshad Hasanov, +26 authors, Padmanee Sharma.
Lancet Gastroenterol Hepatol, 2022 Jan 23; 7(3). PMID: 35065057    Free PMC article.
The ambiguous role of obesity in oncology by promoting cancer but boosting antitumor immunotherapy.
José Antônio Fagundes Assumpção, Gabriel Pasquarelli-do-Nascimento, +2 authors, Kelly Grace Magalhães.
J Biomed Sci, 2022 Feb 16; 29(1). PMID: 35164764    Free PMC article.
Review.
TCR-T Immunotherapy: The Challenges and Solutions.
Yating Liu, Xin Yan, +4 authors, Yumin Li.
Front Oncol, 2022 Feb 12; 11. PMID: 35145905    Free PMC article.
Review.
Comparison of Laboratory Methods for the Clinical Follow Up of Checkpoint Blockade Therapies in Leukemia: Current Status and Challenges Ahead.
Basak Aru, Mojdeh Soltani, +3 authors, Gülderen Yanikkaya Demirel.
Front Oncol, 2022 Feb 15; 12. PMID: 35155232    Free PMC article.
Review.
Molecular Targets of Triple-Negative Breast Cancer: Where Do We Stand?
Emma E Newton, Lauren E Mueller, +2 authors, Heather L Machado.
Cancers (Basel), 2022 Feb 16; 14(3). PMID: 35158750    Free PMC article.
Review.
Chemokine Receptor-Targeted Therapies: Special Case for CCR8.
Bernhard Moser.
Cancers (Basel), 2022 Feb 16; 14(3). PMID: 35158783    Free PMC article.
Review.
Latest Advances in the Use of Therapeutic Focused Ultrasound in the Treatment of Pancreatic Cancer.
Petros X E Mouratidis, Gail Ter Haar.
Cancers (Basel), 2022 Feb 16; 14(3). PMID: 35158903    Free PMC article.
Review.
Novel Therapeutic Opportunities in Neoadjuvant Setting in Urothelial Cancers: A New Horizon Opened by Molecular Classification and Immune Checkpoint Inhibitors.
Maria Lucia Iacovino, Chiara Carmen Miceli, +9 authors, Felice Crocetto.
Int J Mol Sci, 2022 Feb 16; 23(3). PMID: 35163064    Free PMC article.
Review.
Keep a Little Fire Burning-The Delicate Balance of Targeting Sphingosine-1-Phosphate in Cancer Immunity.
Catherine Olesch, Bernhard Brüne, Andreas Weigert.
Int J Mol Sci, 2022 Feb 16; 23(3). PMID: 35163211    Free PMC article.
Review.
PD-L1 Expression in Monocytes Correlates with Bacterial Burden and Treatment Outcomes in Active Pulmonary Tuberculosis.
Sheng-Wei Pan, Chin-Chung Shu, +8 authors, Yuh-Min Chen.
Int J Mol Sci, 2022 Feb 16; 23(3). PMID: 35163542    Free PMC article.
Complement System: An Immunotherapy Target in Colorectal Cancer.
Iman M Talaat, Noha Mousaad Elemam, Maha Saber-Ayad.
Front Immunol, 2022 Feb 18; 13. PMID: 35173724    Free PMC article.
Review.
First-line nivolumab plus ipilimumab combined with two cycles of chemotherapy in advanced non-small cell lung cancer: a subanalysis of Asian patients in CheckMate 9LA.
Thomas John, Hiroshi Sakai, +16 authors, Shun Lu.
Int J Clin Oncol, 2022 Feb 20; 27(4). PMID: 35182247    Free PMC article.
Current applications and future perspective of CRISPR/Cas9 gene editing in cancer.
Si-Wei Wang, Chao Gao, +7 authors, Ai-Wu Ke.
Mol Cancer, 2022 Feb 23; 21(1). PMID: 35189910    Free PMC article.
Review.
Myeloid antigen-presenting cell niches sustain antitumor T cells and license PD-1 blockade via CD28 costimulation.
Jaikumar Duraiswamy, Riccardo Turrini, +33 authors, George Coukos.
Cancer Cell, 2021 Nov 06; 39(12). PMID: 34739845    Free PMC article.
PD-1 and TIGIT downregulation distinctly affect the effector and early memory phenotypes of CD19-targeting CAR T cells.
Young-Ho Lee, Hyeong Ji Lee, +11 authors, Chan Hyuk Kim.
Mol Ther, 2021 Oct 11; 30(2). PMID: 34628052    Free PMC article.
Engineered implantable vaccine platform for continuous antigen-specific immunomodulation.
Dixita Ishani Viswanath, Hsuan-Chen Liu, +4 authors, Alessandro Grattoni.
Biomaterials, 2022 Jan 24; 281. PMID: 35066287    Free PMC article.
Immune Checkpoint Blockade Augments Changes Within Oncolytic Virus-induced Cancer MHC-I Peptidome, Creating Novel Antitumor CD8 T Cell Reactivities.
Youra Kim, Prathyusha Konda, +3 authors, Shashi Gujar.
Mol Cell Proteomics, 2021 Dec 19; 21(2). PMID: 34922008    Free PMC article.
ICAM-1-mediated adhesion is a prerequisite for exosome-induced T cell suppression.
Wei Zhang, Wenqun Zhong, +17 authors, Wei Guo.
Dev Cell, 2022 Jan 28; 57(3). PMID: 35085484    Free PMC article.
The New Era of Immunotherapy in Gastric Cancer.
Shogo Takei, Akihito Kawazoe, Kohei Shitara.
Cancers (Basel), 2022 Feb 26; 14(4). PMID: 35205802    Free PMC article.
Review.
Immune Checkpoint Inhibitors as a Threat to the Hypothalamus-Pituitary Axis: A Completed Puzzle.
Agnese Barnabei, Andrea Corsello, +4 authors, Francesco Torino.
Cancers (Basel), 2022 Feb 26; 14(4). PMID: 35205804    Free PMC article.
Review.
Identification and validation a costimulatory molecule gene signature to predict the prognosis and immunotherapy response for hepatocellular carcinoma.
Yinan Hu, Jingyi Liu, +7 authors, Ying Han.
Cancer Cell Int, 2022 Feb 24; 22(1). PMID: 35193632    Free PMC article.
Immune checkpoint blockade in HIV.
Celine Gubser, Chris Chiu, Sharon R Lewin, Thomas A Rasmussen.
EBioMedicine, 2022 Feb 06; 76. PMID: 35123267    Free PMC article.
Review.
First-line nivolumab + ipilimumab in advanced NSCLC: CheckMate 227 subpopulation analyses in Asian patients.
K J O'Byrne, K H Lee, +14 authors, J-S Lee.
ESMO Open, 2022 Feb 15; 7(1). PMID: 35158207    Free PMC article.
Fc-independent functions of anti-CTLA-4 antibodies contribute to anti-tumor efficacy.
Yosuke Sato, Cierra N Casson, +14 authors, Michael H Shaw.
Cancer Immunol Immunother, 2022 Mar 04;. PMID: 35237846
OIP5 Is a Novel Prognostic Biomarker in Clear Cell Renal Cell Cancer Correlating With Immune Infiltrates.
Mancheng Gong, Yongxiang Li, +4 authors, Runqiang Yuan.
Front Immunol, 2022 Mar 05; 13. PMID: 35242130    Free PMC article.
High Intensity Aerobic exercise training and Immune cell Mobilization in patients with lung cancer (HI AIM)-a randomized controlled trial.
Gitte Holmen Olofsson, Marta Kramer Mikkelsen, +11 authors, Per Thor Straten.
BMC Cancer, 2022 Mar 07; 22(1). PMID: 35247994    Free PMC article.
Tumor Immune Microenvironment and Immunotherapy in Brain Metastasis From Non-Small Cell Lung Cancer.
Yuchang Wang, Rui Chen, +5 authors, Gelei Xiao.
Front Immunol, 2022 Mar 08; 13. PMID: 35251014    Free PMC article.
Review.
An anti-PD-1-GITR-L bispecific agonist induces GITR clustering-mediated T cell activation for cancer immunotherapy.
Sarah Chan, Nicole Belmar, +38 authors, Hamsell M Alvarez.
Nat Cancer, 2022 Mar 09; 3(3). PMID: 35256819    Free PMC article.
Combining nanomedicine and immune checkpoint therapy for cancer immunotherapy.
Christine E Boone, Lu Wang, +2 authors, Nicole F Steinmetz.
Wiley Interdiscip Rev Nanomed Nanobiotechnol, 2021 Jul 24; 14(1). PMID: 34296535    Free PMC article.
Review.
Anti-PD-L1 peptide-conjugated prodrug nanoparticles for targeted cancer immunotherapy combining PD-L1 blockade with immunogenic cell death.
Yujeong Moon, Man Kyu Shim, +8 authors, Kwangmeyung Kim.
Theranostics, 2022 Mar 11; 12(5). PMID: 35265195    Free PMC article.
Immunotherapy Associated Neurotoxicity in Pediatric Oncology.
Haneen Shalabi, Anandani Nellan, Nirali N Shah, Juliane Gust.
Front Oncol, 2022 Mar 11; 12. PMID: 35265526    Free PMC article.
Review.
Improvement of the anticancer efficacy of PD-1/PD-L1 blockade via combination therapy and PD-L1 regulation.
Mengling Wu, Qianrui Huang, +4 authors, Yong Xia.
J Hematol Oncol, 2022 Mar 14; 15(1). PMID: 35279217    Free PMC article.
Review.
Soluble Immune Checkpoints Are Dysregulated in COVID-19 and Heavy Alcohol Users With HIV Infection.
Wei Li, Fahim Syed, +10 authors, Qigui Yu.
Front Immunol, 2022 Mar 15; 13. PMID: 35281051    Free PMC article.
Review.
An Asia-specific variant of human IgG1 represses colorectal tumorigenesis by shaping the tumor microenvironment.
Bing Yang, Zhen Zhang, +30 authors, Wanli Liu.
J Clin Invest, 2022 Feb 09; 132(6). PMID: 35133976    Free PMC article.
A FBXO7/EYA2-SCFFBXW7 axis promotes AXL-mediated maintenance of mesenchymal and immune evasion phenotypes of cancer cells.
Jia Z Shen, Zhixin Qiu, +13 authors, Charles Spruck.
Mol Cell, 2022 Feb 20; 82(6). PMID: 35182481    Free PMC article.
Efficacy and Safety of Anti-PD1/PDL1 in Advanced Biliary Tract Cancer: A Systematic Review and Meta-Analysis.
Qi Jiang, Jinsheng Huang, +5 authors, Guifang Guo.
Front Immunol, 2022 Mar 22; 13. PMID: 35309350    Free PMC article.
Systematic Review.
Comparison of Treatment Efficacy and Survival Outcomes Between Asian and Western Patients With Unresectable Gastric or Gastro-Esophageal Adenocarcinoma: A Systematic Review and Meta-Analysis.
Zhening Zhang, Zining Liu, Zeyang Chen.
Front Oncol, 2022 Mar 25; 12. PMID: 35321436    Free PMC article.
Systematic Review.
Tumor Immunology and Immunotherapy of Non-Small-Cell Lung Cancer.
Tina Cascone, Jared Fradette, Monika Pradhan, Don L Gibbons.
Cold Spring Harb Perspect Med, 2021 Sep 29; 12(5). PMID: 34580079    Free PMC article.
Review.
Short and Long-Term Toxicity in Pediatric Cancer Treatment: Central Nervous System Damage.
Iside Alessi, Anna Maria Caroleo, +14 authors, Umberto Raucci.
Cancers (Basel), 2022 Mar 26; 14(6). PMID: 35326692    Free PMC article.
Review.
Simultaneous Genetic Ablation of PD-1, LAG-3, and TIM-3 in CD8 T Cells Delays Tumor Growth and Improves Survival Outcome.
Elisa Ciraolo, Stefanie Althoff, +6 authors, Il-Kang Na.
Int J Mol Sci, 2022 Mar 26; 23(6). PMID: 35328630    Free PMC article.
The promise and perils of immunotherapy.
Stefanie Lesch, Saar Gill.
Blood Adv, 2021 Sep 29; 5(18). PMID: 34581774    Free PMC article.
Review.
MYC inhibition reprograms tumor immune microenvironment by recruiting T lymphocytes and activating the CD40/CD40L system in osteosarcoma.
Kuo Jiang, Qianfeng Zhang, +10 authors, Lequn Shan.
Cell Death Discov, 2022 Mar 17; 8(1). PMID: 35292660    Free PMC article.
Promoting antibody-dependent cellular phagocytosis for effective macrophage-based cancer immunotherapy.
Xu Cao, Jing Chen, +9 authors, Mingye Feng.
Sci Adv, 2022 Mar 19; 8(11). PMID: 35302839    Free PMC article.
A Novel Prognostic Ferroptosis-Related lncRNA Signature Associated with Immune Landscape in Invasive Breast Cancer.
Shuang Shen, Danhe Yang, +3 authors, Xiaochi Hu.
Dis Markers, 2022 Apr 02; 2022. PMID: 35359880    Free PMC article.
Nivolumab plus chemotherapy or ipilimumab in gastro-oesophageal cancer.
Kohei Shitara, Jaffer A Ajani, +26 authors, Yelena Y Janjigian.
Nature, 2022 Mar 25; 603(7903). PMID: 35322232    Free PMC article.
Grading Central Diabetes Insipidus Induced by Immune Checkpoint Inhibitors: A Challenging Task.
Agnese Barnabei, Lidia Strigari, +5 authors, Francesco Torino.
Front Endocrinol (Lausanne), 2022 Apr 08; 13. PMID: 35388297    Free PMC article.
Review.
Tumor immunotherapies by immune checkpoint inhibitors (ICIs); the pros and cons.
Adel Naimi, Rebar N Mohammed, +11 authors, Ehsan Razeghian.
Cell Commun Signal, 2022 Apr 09; 20(1). PMID: 35392976    Free PMC article.
Review.
Outcomes of immunomodulatory and biologic therapy in people living with HIV.
Michael J Peluso, Jessica Chen, +5 authors, Peter V Chin-Hong.
AIDS, 2020 Apr 21; 34(8). PMID: 32310901    Free PMC article.
Single-Cell Profiling Reveals Heterogeneity of Primary and Lymph Node Metastatic Tumors and Immune Cell Populations and Discovers Important Prognostic Significance of CCDC43 in Oral Squamous Cell Carcinoma.
Zhenyu Wang, Hongbo Zhang, +3 authors, Muying Ying.
Front Immunol, 2022 Apr 12; 13. PMID: 35401551    Free PMC article.
Immunotherapy Combined With Chemotherapy for Postoperative Recurrent Penile Squamous Cell Carcinoma: A Case Report and Literature Review.
Na Li, Tangpeng Xu, +3 authors, Xiangpan Li.
Front Oncol, 2022 Apr 12; 12. PMID: 35402270    Free PMC article.
Data-driven learning how oncogenic gene expression locally alters heterocellular networks.
David J Klinke, Audry Fernandez, +3 authors, Anika C Pirkey.
Nat Commun, 2022 Apr 15; 13(1). PMID: 35418177    Free PMC article.
Harnessing Liquid Biopsies to Guide Immune Checkpoint Inhibitor Therapy.
Shadma Fatima, Yafeng Ma, +7 authors, Paul de Souza.
Cancers (Basel), 2022 Apr 13; 14(7). PMID: 35406441    Free PMC article.
Review.
Eosinophils and melanoma: Implications for immunotherapy.
India Robinson, Gabriella Santa Lucia, +6 authors, Manuel Valdebran.
Pigment Cell Melanoma Res, 2021 Dec 21; 35(2). PMID: 34927354    Free PMC article.
Review.
Development and characterization of anti-galectin-9 antibodies that protect T cells from galectin-9-induced cell death.
Riyao Yang, Linlin Sun, +7 authors, Mien-Chie Hung.
J Biol Chem, 2022 Mar 15; 298(4). PMID: 35283189    Free PMC article.
Identification of molecular subtypes premised on the characteristics of immune infiltration of endometrial cancer.
Cong Liu, Yan Zhang, Chen Hang.
Ann Transl Med, 2022 Apr 19; 10(6). PMID: 35433941    Free PMC article.
Heterogeneous Outcomes of Immune Checkpoint Inhibitor Rechallenge in Patients With NSCLC: A Systematic Review and Meta-Analysis.
Shiting Xu, Takehito Shukuya, +8 authors, Kazuhisa Takahashi.
JTO Clin Res Rep, 2022 Apr 19; 3(4). PMID: 35434666    Free PMC article.
Resolving genetic heterogeneity in cancer.
Samra Turajlic, Andrea Sottoriva, Trevor Graham, Charles Swanton.
Nat Rev Genet, 2019 Mar 29; 20(7). PMID: 30918367
Highly Cited. Review.
γδ T cells: pleiotropic immune effectors with therapeutic potential in cancer.
Bruno Silva-Santos, Sofia Mensurado, Seth B Coffelt.
Nat Rev Cancer, 2019 Jun 19; 19(7). PMID: 31209264
Highly Cited. Review.
Understanding Drug Sensitivity and Tackling Resistance in Cancer.
Jeffrey W Tyner, Franziska Haderk, +12 authors, Christopher D Willey.
Cancer Res, 2022 Feb 24; 82(8). PMID: 35195258    Free PMC article.
Sensitizing immune unresponsive colorectal cancers to immune checkpoint inhibitors through MAVS overexpression.
Bin-Jin Hwang, Li-Chung Tsao, +10 authors, Zachary Conrad Hartman.
J Immunother Cancer, 2022 Apr 02; 10(3). PMID: 35361727    Free PMC article.
Anti-angiogenesis revisited: reshaping the treatment landscape of advanced non-small cell lung cancer.
Sun Ha Choi, Seung Soo Yoo, Shin Yup Lee, Jae Yong Park.
Arch Pharm Res, 2022 Apr 23; 45(4). PMID: 35449345
Review.
Immunolocalization of CD80 and CD86 in Non-Small Cell Lung Carcinoma: CD80 as a Potent Prognostic Factor.
Takashi Sato, Kiyoshi Takagi, +7 authors, Hiroshi Hojo.
Acta Histochem Cytochem, 2022 Apr 22; 55(1). PMID: 35444349    Free PMC article.
The Prognostic Significance of RIMKLB and Related Immune Infiltrates in Colorectal Cancers.
Yinghao Cao, Shenghe Deng, +16 authors, Kailin Cai.
Front Genet, 2022 Apr 22; 13. PMID: 35444692    Free PMC article.
Cutaneous Adverse Events Associated with Immune Checkpoint Inhibitors: A Review Article.
Chieh-Hsun Chen, Hsin-Su Yu, Sebastian Yu.
Curr Oncol, 2022 Apr 22; 29(4). PMID: 35448208    Free PMC article.
Review.
Combining Radiotherapy and Immunotherapy in Metastatic Breast Cancer: Current Status and Future Directions.
Steven David, Jennifer Tan, +3 authors, Sherene Loi.
Biomedicines, 2022 Apr 24; 10(4). PMID: 35453571    Free PMC article.
Review.
Gut microbiota influence immunotherapy responses: mechanisms and therapeutic strategies.
Yuting Lu, Xiangliang Yuan, +4 authors, Qin Li.
J Hematol Oncol, 2022 Apr 30; 15(1). PMID: 35488243    Free PMC article.
Review.
Brain Metastasis Organotropism.
Arseniy E Yuzhalin, Dihua Yu.
Cold Spring Harb Perspect Med, 2019 Sep 25; 10(5). PMID: 31548224    Free PMC article.
Review.
Holistic Approach to Immune Checkpoint Inhibitor-Related Adverse Events.
Remo Poto, Teresa Troiani, +4 authors, Gilda Varricchi.
Front Immunol, 2022 Apr 19; 13. PMID: 35432346    Free PMC article.
Review.
Predictable Clinical Benefits without Evidence of Synergy in Trials of Combination Therapies with Immune-Checkpoint Inhibitors.
Adam C Palmer, Benjamin Izar, Haeun Hwangbo, Peter K Sorger.
Clin Cancer Res, 2022 Jan 21; 28(2). PMID: 35045958    Free PMC article.
Targeting the PSGL-1 Immune Checkpoint Promotes Immunity to PD-1-Resistant Melanoma.
Julia M DeRogatis, Karla M Viramontes, +3 authors, Roberto Tinoco.
Cancer Immunol Res, 2022 Mar 19; 10(5). PMID: 35303066    Free PMC article.
CD36, a signaling receptor and fatty acid transporter that regulates immune cell metabolism and fate.
Yiliang Chen, Jue Zhang, Weiguo Cui, Roy L Silverstein.
J Exp Med, 2022 Apr 20; 219(6). PMID: 35438721    Free PMC article.
Review.
HIF inhibitor 32-134D eradicates murine hepatocellular carcinoma in combination with anti-PD1 therapy.
Shaima Salman, David J Meyers, +11 authors, Gregg L Semenza.
J Clin Invest, 2022 May 03; 132(9). PMID: 35499076    Free PMC article.
PD-1/PD-L1 Inhibitor-Associated Myocarditis: Epidemiology, Characteristics, Diagnosis, Treatment, and Potential Mechanism.
Hao Dong, Yihang Qi, +3 authors, Jing Wang.
Front Pharmacol, 2022 May 07; 13. PMID: 35517794    Free PMC article.
Review.
The mutual relationship between the host immune system and radiotherapy: stimulating the action of immune cells by irradiation.
Tsubasa Watanabe, Genki Edward Sato, +2 authors, Takashi Mizowaki.
Int J Clin Oncol, 2022 May 14;. PMID: 35556190
Review.
A decade of checkpoint blockade immunotherapy in melanoma: understanding the molecular basis for immune sensitivity and resistance.
Alexander C Huang, Roberta Zappasodi.
Nat Immunol, 2022 Mar 05; 23(5). PMID: 35241833    Free PMC article.
Review.
Tumor mutational burden presents limiting effects on predicting the efficacy of immune checkpoint inhibitors and prognostic assessment in adrenocortical carcinoma.
Fangshi Xu, Yibing Guan, +5 authors, Bin-Cheng Ren.
BMC Endocr Disord, 2022 May 16; 22(1). PMID: 35568842    Free PMC article.
The Role of Extracellular Vesicles in Metabolic Reprogramming of the Tumor Microenvironment.
Eran S Fridman, Lana Ginini, Ziv Gil.
Cells, 2022 May 15; 11(9). PMID: 35563739    Free PMC article.
Review.
High Dose Local Photon Irradiation Is Crucial in Anti-CTLA-4 Antibody Therapy to Enhance the Abscopal Response in a Murine Pancreatic Carcinoma Model.
Junya Yamamoto, Yutaka Takahashi, +9 authors, Masahiko Koizumi.
Cancers (Basel), 2022 May 15; 14(9). PMID: 35565217    Free PMC article.
What Zebrafish and Nanotechnology Can Offer for Cancer Treatments in the Age of Personalized Medicine.
María Cascallar, Sandra Alijas, +4 authors, María de la Fuente.
Cancers (Basel), 2022 May 15; 14(9). PMID: 35565373    Free PMC article.
Review.
Drug resistance in cancer immunotherapy: new strategies to improve checkpoint inhibitor therapies.
Jesus Rodriguez-Pascual, Angel Ayuso-Sacido, Cristobal Belda-Iniesta.
Cancer Drug Resist, 2019 Dec 19; 2(4). PMID: 35582274    Free PMC article.
Review.
A review of mechanisms of resistance to immune checkpoint inhibitors and potential strategies for therapy.
Yu Fujiwara, Arjun Mittra, Abdul Rafeh Naqash, Naoko Takebe.
Cancer Drug Resist, 2020 Jun 18; 3(3). PMID: 35582437    Free PMC article.
Review.
Immuno-reactive cancer organoid model to assess effects of the microbiome on cancer immunotherapy.
Ethan Shelkey, David Oommen, +5 authors, Shay Soker.
Sci Rep, 2022 Jun 16; 12(1). PMID: 35705580
Identification of a novel prognostic signature for HCC and analysis of costimulatory molecule-related lncRNA AC099850.3.
Qi Wang, Qiong Fang, +2 authors, Meimei Liu.
Sci Rep, 2022 Jun 16; 12(1). PMID: 35705628