Journal Article
. 2018 Aug; 50(9):1271-1281.
doi: 10.1038/s41588-018-0200-2.

Genomic correlates of response to immune checkpoint blockade in microsatellite-stable solid tumors

Diana Miao 1 Claire A Margolis 1 Natalie I Vokes 1 David Liu 1 Amaro Taylor-Weiner 1 Stephanie M Wankowicz 1 Dennis Adeegbe 2 Daniel Keliher 1 Bastian Schilling 3 Adam Tracy 4 Michael Manos 1 Nicole G Chau 1 Glenn J Hanna 1 Paz Polak 4 Scott J Rodig 1 Sabina Signoretti 1 Lynette M Sholl 1 Jeffrey A Engelman 5 Gad Getz 4 Pasi A Jänne 1 Robert I Haddad 1 Toni K Choueiri 1 David A Barbie 1 Rizwan Haq 1 Mark M Awad 1 Dirk Schadendorf 1 F Stephen Hodi 1 Joaquim Bellmunt 1 Kwok-Kin Wong 1 Peter Hammerman 1 Eliezer M Van Allen 6 
  • PMID: 30150660
  •     61 References
  •     172 citations


Tumor mutational burden correlates with response to immune checkpoint blockade in multiple solid tumors, although in microsatellite-stable tumors this association is of uncertain clinical utility. Here we uniformly analyzed whole-exome sequencing (WES) of 249 tumors and matched normal tissue from patients with clinically annotated outcomes to immune checkpoint therapy, including radiographic response, across multiple cancer types to examine additional tumor genomic features that contribute to selective response. Our analyses identified genomic correlates of response beyond mutational burden, including somatic events in individual driver genes, certain global mutational signatures, and specific HLA-restricted neoantigens. However, these features were often interrelated, highlighting the complexity of identifying genetic driver events that generate an immunoresponsive tumor environment. This study lays a path forward in analyzing large clinical cohorts in an integrated and multifaceted manner to enhance the ability to discover clinically meaningful predictive features of response to immune checkpoint blockade.

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Xinyi Wang, Jinzhong Duanmu, +2 authors, Qunguang Jiang.
J Transl Med, 2020 Aug 30; 18(1). PMID: 32859214    Free PMC article.
A pan-cancer analysis of PBAF complex mutations and their association with immunotherapy response.
A Ari Hakimi, Kyrollis Attalla, +14 authors, Robert J Motzer.
Nat Commun, 2020 Aug 21; 11(1). PMID: 32820162    Free PMC article.
Association of MUC16 Mutation With Response to Immune Checkpoint Inhibitors in Solid Tumors.
Lei Zhang, Xiaohong Han, Yuankai Shi.
JAMA Netw Open, 2020 Aug 28; 3(8). PMID: 32845327    Free PMC article.
Next-Generation Sequencing of Advanced GI Tumors Reveals Individual Treatment Options.
Michael Bitzer, Leonie Ostermann, +15 authors, Nisar P Malek.
JCO Precis Oncol, 2020 Sep 15; 4. PMID: 32923905    Free PMC article.
From Single Level Analysis to Multi-Omics Integrative Approaches: A Powerful Strategy towards the Precision Oncology.
Maria Eugenia Gallo Cantafio, Katia Grillone, +6 authors, Maria Teresa Di Martino.
High Throughput, 2018 Oct 31; 7(4). PMID: 30373182    Free PMC article.
Current views on tumor mutational burden in patients with non-small cell lung cancer treated by immune checkpoint inhibitors.
Léa Berland, Simon Heeke, +11 authors, Marius Ilié.
J Thorac Dis, 2019 Feb 19; 11(Suppl 1). PMID: 30775030    Free PMC article.
The emerging links between chromosomal instability (CIN), metastasis, inflammation and tumour immunity.
Andréa E Tijhuis, Sarah C Johnson, Sarah E McClelland.
Mol Cytogenet, 2019 May 23; 12. PMID: 31114634    Free PMC article.
MUC4, MUC16, and TTN genes mutation correlated with prognosis, and predicted tumor mutation burden and immunotherapy efficacy in gastric cancer and pan-cancer.
Yue Yang, Jieyun Zhang, +3 authors, Weijian Guo.
Clin Transl Med, 2020 Sep 09; 10(4). PMID: 32898332    Free PMC article.
New biomarkers for checkpoint inhibitor therapy.
Nikki Burdett, Jayesh Desai.
ESMO Open, 2020 Sep 17; 5(Suppl 1). PMID: 32933940    Free PMC article.
Evaluation of Programmed Death Ligand 1 (PD-L1) Gene Amplification and Response to Nivolumab Monotherapy in Non-small Cell Lung Cancer.
Yusuke Inoue, Katsuhiro Yoshimura, +24 authors, Takafumi Suda.
JAMA Netw Open, 2020 Sep 22; 3(9). PMID: 32955570    Free PMC article.
Multimodal genomic features predict outcome of immune checkpoint blockade in non-small-cell lung cancer.
Valsamo Anagnostou, Noushin Niknafs, +32 authors, Victor E Velculescu.
Nat Cancer, 2020 Sep 29; 1(1). PMID: 32984843    Free PMC article.
Screening Cancer Immunotherapy: When Engineering Approaches Meet Artificial Intelligence.
Xingwu Zhou, Moyuan Qu, +9 authors, Ali Khademhosseini.
Adv Sci (Weinh), 2020 Oct 13; 7(19). PMID: 33042756    Free PMC article.
Clinical advantage of targeted sequencing for unbiased tumor mutational burden estimation in samples with low tumor purity.
Tae Hee Hong, Hongui Cha, +17 authors, Woong-Yang Park.
J Immunother Cancer, 2020 Oct 21; 8(2). PMID: 33077514    Free PMC article.
Targeting DNA Repair, Cell Cycle, and Tumor Microenvironment in B Cell Lymphoma.
Paul J Bröckelmann, Mathilde R W de Jong, Ron D Jachimowicz.
Cells, 2020 Oct 18; 9(10). PMID: 33066395    Free PMC article.
Integration of the Tumor Mutational Burden and Tumor Heterogeneity Identify an Immunological Subtype of Melanoma With Favorable Survival.
Yanmei Gao, Chunhe Yang, +3 authors, Yadong Yang.
Front Oncol, 2020 Nov 17; 10. PMID: 33194669    Free PMC article.
Integrated genomic analysis identifies a genetic mutation model predicting response to immune checkpoint inhibitors in melanoma.
Junjie Jiang, Yongfeng Ding, +5 authors, Lisong Teng.
Cancer Med, 2020 Sep 25; 9(22). PMID: 32969604    Free PMC article.
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Characterizing diversity in the tumor-immune microenvironment of distinct subclasses of gastroesophageal adenocarcinomas.
S Derks, L K de Klerk, +17 authors, A J Bass.
Ann Oncol, 2020 May 11; 31(8). PMID: 32387455    Free PMC article.
Breast Cancer Heterogeneity and Response to Novel Therapeutics.
Mariona Baliu-Piqué, Atanasio Pandiella, Alberto Ocana.
Cancers (Basel), 2020 Nov 11; 12(11). PMID: 33167363    Free PMC article.
CRISPR-GEMM Pooled Mutagenic Screening Identifies KMT2D as a Major Modulator of Immune Checkpoint Blockade.
Guangchuan Wang, Ryan D Chow, +16 authors, Sidi Chen.
Cancer Discov, 2020 Sep 06; 10(12). PMID: 32887696    Free PMC article.
Tumor Mutational Burden as a Predictive Biomarker in Solid Tumors.
Dan Sha, Zhaohui Jin, +3 authors, Frank A Sinicrope.
Cancer Discov, 2020 Nov 04; 10(12). PMID: 33139244    Free PMC article.
Integrated molecular drivers coordinate biological and clinical states in melanoma.
Jake R Conway, Felix Dietlein, +13 authors, Eliezer M Van Allen.
Nat Genet, 2020 Nov 25; 52(12). PMID: 33230298    Free PMC article.
SITC cancer immunotherapy resource document: a compass in the land of biomarker discovery.
Siwen Hu-Lieskovan, Srabani Bhaumik, +14 authors, Holden T Maecker.
J Immunother Cancer, 2020 Dec 04; 8(2). PMID: 33268350    Free PMC article.
EPHA mutation as a predictor of immunotherapeutic efficacy in lung adenocarcinoma.
Hua Bai, Jianchun Duan, +14 authors, Zhijie Wang.
J Immunother Cancer, 2020 Dec 12; 8(2). PMID: 33303576    Free PMC article.
Low intratumor heterogeneity correlates with increased response to PD-1 blockade in renal cell carcinoma.
Xia Ran, Jinyuan Xiao, +5 authors, Zhongsheng Sun.
Ther Adv Med Oncol, 2021 Jan 12; 12. PMID: 33425025    Free PMC article.
Three Immune-Associated Subtypes of Diffuse Glioma Differ in Immune Infiltration, Immune Checkpoint Molecules, and Prognosis.
Quanwei Zhou, Xuejun Yan, +5 authors, Caiping Ren.
Front Oncol, 2021 Jan 12; 10. PMID: 33425739    Free PMC article.
Apolipoprotein C1 stimulates the malignant process of renal cell carcinoma via the Wnt3a signaling.
Hao Jiang, Jing-Yuan Tang, +4 authors, Xiao-Zhou He.
Cancer Cell Int, 2021 Jan 13; 21(1). PMID: 33430855    Free PMC article.
Advances in the development of personalized neoantigen-based therapeutic cancer vaccines.
Eryn Blass, Patrick A Ott.
Nat Rev Clin Oncol, 2021 Jan 22; 18(4). PMID: 33473220    Free PMC article.
Whole-genome doubling confers unique genetic vulnerabilities on tumour cells.
Ryan J Quinton, Amanda DiDomizio, +12 authors, Neil J Ganem.
Nature, 2021 Jan 29; 590(7846). PMID: 33505027    Free PMC article.
Neoadjuvant PD-L1 plus CTLA-4 blockade in patients with cisplatin-ineligible operable high-risk urothelial carcinoma.
Jianjun Gao, Neema Navai, +28 authors, Padmanee Sharma.
Nat Med, 2020 Oct 14; 26(12). PMID: 33046869
Intratumoral immunosuppression profiles in 11q-deleted neuroblastomas provide new potential therapeutic targets.
Esther Coronado, Yania Yañez, +8 authors, Jaime Font de Mora.
Mol Oncol, 2020 Dec 01; 15(2). PMID: 33252831    Free PMC article.
KRAS mutations are negatively correlated with immunity in colon cancer.
Xiaorui Fu, Xinyi Wang, +2 authors, Qunguang Jiang.
Aging (Albany NY), 2020 Dec 01; 13(1). PMID: 33254149    Free PMC article.
EPHA7 mutation as a predictive biomarker for immune checkpoint inhibitors in multiple cancers.
Zhen Zhang, Hao-Xiang Wu, +4 authors, Hui-Yan Luo.
BMC Med, 2021 Feb 03; 19(1). PMID: 33526018    Free PMC article.
Atezolizumab prolongs overall survival over docetaxel in advanced non-small-cell lung cancer patients harboring STK11 or KEAP1 mutation.
Wei Nie, Lu Gan, +17 authors, Bao-Hui Han.
Oncoimmunology, 2021 Feb 05; 10(1). PMID: 33537171    Free PMC article.
Comprehensive Characterization of Immunological Profiles and Clinical Significance in Hepatocellular Carcinoma.
Ping Tao, Liang Hong, +5 authors, Ruyi Xue.
Front Oncol, 2021 Feb 09; 10. PMID: 33552954    Free PMC article.
Distinctive genomic characteristics in POLE/POLD1-mutant cancers can potentially predict beneficial clinical outcomes in patients who receive immune checkpoint inhibitor.
Junjun He, Wei Ouyang, +8 authors, Wencai Li.
Ann Transl Med, 2021 Feb 12; 9(2). PMID: 33569431    Free PMC article.
Intratumoral heterogeneity in cancer progression and response to immunotherapy.
Ilio Vitale, Efrat Shema, Sherene Loi, Lorenzo Galluzzi.
Nat Med, 2021 Feb 13; 27(2). PMID: 33574607
Understanding adverse events of immunotherapy: A mechanistic perspective.
Kelly P Burke, Stephanie Grebinoski, Arlene H Sharpe, Dario A A Vignali.
J Exp Med, 2021 Feb 19; 218(1). PMID: 33601411    Free PMC article.
The Genetic Evolution of Treatment-Resistant Cutaneous, Acral, and Uveal Melanomas.
Alvin P Makohon-Moore, Evan J Lipson, +19 authors, Christine A Iacobuzio-Donahue.
Clin Cancer Res, 2020 Dec 17; 27(5). PMID: 33323400    Free PMC article.
Genomic alterations in KMT2 family predict outcome of immune checkpoint therapy in multiple cancers.
Peng Zhang, Yixuan Huang.
J Hematol Oncol, 2021 Mar 04; 14(1). PMID: 33653367    Free PMC article.
The Role of Real-Time Contrast-Enhanced Ultrasound in Guiding Radiofrequency Ablation of Reninoma: Case Report and Literature Review.
Rui Zhang, Ming Xu, Xiao-Yan Xie.
Front Oncol, 2021 Mar 10; 11. PMID: 33686368    Free PMC article.
Personalized Immuno-Oncology.
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Med Princ Pract, 2020 Aug 26; 30(1). PMID: 32841942    Free PMC article.
Meta-analysis of tumor- and T cell-intrinsic mechanisms of sensitization to checkpoint inhibition.
Kevin Litchfield, James L Reading, +25 authors, Charles Swanton.
Cell, 2021 Jan 29; 184(3). PMID: 33508232    Free PMC article.
Circulating mucosal-associated invariant T cells identify patients responding to anti-PD-1 therapy.
Sara De Biasi, Lara Gibellini, +16 authors, Andrea Cossarizza.
Nat Commun, 2021 Mar 17; 12(1). PMID: 33723257    Free PMC article.
Tumor mutational burden as a predictor of immunotherapy response in breast cancer.
Tess A O'Meara, Sara M Tolaney.
Oncotarget, 2021 Mar 23; 12(5). PMID: 33747355    Free PMC article.
Targeting natural splicing plasticity of APOBEC3B restricts its expression and mutagenic activity.
A Rouf Banday, Olusegun O Onabajo, +10 authors, Ludmila Prokunina-Olsson.
Commun Biol, 2021 Mar 24; 4(1). PMID: 33753867    Free PMC article.
Advanced Melanoma: Resistance Mechanisms to Current Therapies.
Alexandra M Haugh, April K S Salama, Douglas B Johnson.
Hematol Oncol Clin North Am, 2021 Mar 25; 35(1). PMID: 33759769    Free PMC article.
Effect of NCOR1 Mutations on Immune Microenvironment and Efficacy of Immune Checkpoint Inhibitors in Patient with Bladder Cancer.
Anqi Lin, Zhengang Qiu, Jian Zhang, Peng Luo.
Front Immunol, 2021 Mar 26; 12. PMID: 33763074    Free PMC article.
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S Laban, M Brand, +5 authors, T K Hoffmann.
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Copy number loss in granzyme genes confers resistance to immune checkpoint inhibitor in nasopharyngeal carcinoma.
Yuxiang Ma, Xi Chen, +12 authors, Li Zhang.
J Immunother Cancer, 2021 Mar 20; 9(3). PMID: 33737344    Free PMC article.
Germline variants predictive of tumor mutational burden and immune checkpoint inhibitor efficacy.
Ajay Chatrath, Aakrosh Ratan, Anindya Dutta.
iScience, 2021 Apr 01; 24(3). PMID: 33786423    Free PMC article.
Current Treatment Landscape of Nasopharyngeal Carcinoma and Potential Trials Evaluating the Value of Immunotherapy.
Quynh Thu Le, A Dimitrios Colevas, +9 authors, Shakun Malik.
J Natl Cancer Inst, 2019 Mar 27; 111(7). PMID: 30912808    Free PMC article.
Molecular profiling of long-term responders to immune checkpoint inhibitors in advanced non-small cell lung cancer.
Joan Frigola, Alejandro Navarro, +17 authors, Ramon Amat.
Mol Oncol, 2020 Dec 21; 15(4). PMID: 33342055    Free PMC article.
High tumor mutation burden fails to predict immune checkpoint blockade response across all cancer types.
D J McGrail, P G Pilié, +13 authors, S-Y Lin.
Ann Oncol, 2021 Mar 20; 32(5). PMID: 33736924    Free PMC article.
Curative-Intent Treatment with Durvalumab in Early-Stage Cancers.
Giovanni Melillo, Vikram Chand, +2 authors, Cristian Massacesi.
Adv Ther, 2021 Apr 22; 38(6). PMID: 33881745    Free PMC article.
RB1 and TP53 co-mutations correlate strongly with genomic biomarkers of response to immunity checkpoint inhibitors in urothelial bladder cancer.
Ramon Gonzalez Manzano, Ana Catalan-Latorre, Antonio Brugarolas.
BMC Cancer, 2021 Apr 22; 21(1). PMID: 33879103    Free PMC article.
MGA Mutation as a Novel Biomarker for Immune Checkpoint Therapies in Non-Squamous Non-Small Cell Lung Cancer.
Lei Sun, Man Li, +4 authors, Linlang Guo.
Front Pharmacol, 2021 May 01; 12. PMID: 33927616    Free PMC article.
Cytotoxic lymphocytes target characteristic biophysical vulnerabilities in cancer.
Maria Tello-Lafoz, Katja Srpan, +12 authors, Ekrem Emrah Er.
Immunity, 2021 Mar 24; 54(5). PMID: 33756102    Free PMC article.
Strategies for the Construction of Mouse Models With Humanized Immune System and Evaluation of Tumor Immune Checkpoint Inhibitor Therapy.
Wenwen Guo, Caiqin Zhang, +2 authors, Changhong Shi.
Front Oncol, 2021 May 18; 11. PMID: 33996603    Free PMC article.
Identification of combinations of somatic mutations that predict cancer survival and immunotherapy benefit.
Ayal B Gussow, Eugene V Koonin, Noam Auslander.
NAR Cancer, 2021 May 25; 3(2). PMID: 34027407    Free PMC article.
The temporal mutational and immune tumour microenvironment remodelling of HER2-negative primary breast cancers.
Leticia De Mattos-Arruda, Javier Cortes, +17 authors, Carlos Caldas.
NPJ Breast Cancer, 2021 Jun 09; 7(1). PMID: 34099718    Free PMC article.
Association Between FSIP2 Mutation and an Improved Efficacy of Immune Checkpoint Inhibitors in Patients With Skin Cutaneous Melanoma.
Haoxuan Ying, Anqi Lin, +2 authors, Peng Luo.
Front Mol Biosci, 2021 Jun 12; 8. PMID: 34113648    Free PMC article.
Peripheral CD8+ T cell characteristics associated with durable responses to immune checkpoint blockade in patients with metastatic melanoma.
Benjamin P Fairfax, Chelsea A Taylor, +12 authors, Mark R Middleton.
Nat Med, 2020 Feb 12; 26(2). PMID: 32042196    Free PMC article.
Catenin Alpha-2 Mutation Changes the Immune Microenvironment in Lung Adenocarcinoma Patients Receiving Immune Checkpoint Inhibitors.
Yang Wen, Anqi Lin, +4 authors, Jian Zhang.
Front Pharmacol, 2021 Jun 25; 12. PMID: 34163353    Free PMC article.
Pan-cancer analysis of SETD2 mutation and its association with the efficacy of immunotherapy.
Mingdong Lu, Bin Zhao, +4 authors, Xian Shen.
NPJ Precis Oncol, 2021 Jun 16; 5(1). PMID: 34127768    Free PMC article.
Massive PD-L1 and CD8 double positive TILs characterize an immunosuppressive microenvironment with high mutational burden in lung cancer.
Libin Zhang, Yanhui Chen, +10 authors, Hao Peng.
J Immunother Cancer, 2021 Jun 19; 9(6). PMID: 34140315    Free PMC article.
Multi-omics analysis reveals prognostic value of tumor mutation burden in hepatocellular carcinoma.
Qianhui Xu, Hao Xu, +5 authors, Wen Huang.
Cancer Cell Int, 2021 Jul 05; 21(1). PMID: 34217320    Free PMC article.
Prognostic and immunological role of CD36: A pan-cancer analysis.
Yong-Jian Chen, Wei-Xin Liao, +7 authors, Xing Li.
J Cancer, 2021 Jul 09; 12(16). PMID: 34234847    Free PMC article.
Identification of NOTCH4 mutation as a response biomarker for immune checkpoint inhibitor therapy.
Junyu Long, Dongxu Wang, +8 authors, Haitao Zhao.
BMC Med, 2021 Jul 22; 19(1). PMID: 34284787    Free PMC article.
Emerging targets for anticancer vaccination: IDH.
M Platten, L Bunse, W Wick.
ESMO Open, 2021 Jul 17; 6(4). PMID: 34271312    Free PMC article.
The Impact of NOTCH Pathway Alteration on Tumor Microenvironment and Clinical Survival of Immune Checkpoint Inhibitors in NSCLC.
Xiaohua Li, Yuntao Wang, +3 authors, Yifeng Bai.
Front Immunol, 2021 Jul 27; 12. PMID: 34305884    Free PMC article.
Immunogenomic determinants of tumor microenvironment correlate with superior survival in high-risk neuroblastoma.
Riyue Bao, Stefani Spranger, +7 authors, Ami V Desai.
J Immunother Cancer, 2021 Jul 18; 9(7). PMID: 34272305    Free PMC article.
Epidemiology, Risk Assessment, and Biomarkers for Patients with Advanced Renal Cell Carcinoma.
Kyrollis Attalla, Stanley Weng, Martin H Voss, A Ari Hakimi.
Urol Clin North Am, 2020 Jul 01; 47(3). PMID: 32600532    Free PMC article.
The Promises and Challenges of Tumor Mutation Burden as an Immunotherapy Biomarker: A Perspective from the International Association for the Study of Lung Cancer Pathology Committee.
Lynette M Sholl, Fred R Hirsch, +35 authors, John W Longshore.
J Thorac Oncol, 2020 Jun 12; 15(9). PMID: 32522712    Free PMC article.
TGFBR2 mutation predicts resistance to immune checkpoint inhibitors in patients with non-small cell lung cancer.
Teng Li, Han Wang, +8 authors, Zhijie Wang.
Ther Adv Med Oncol, 2021 Aug 20; 13. PMID: 34408796    Free PMC article.
Predictive Value of the TP53/PIK3CA/ATM Mutation Classifier for Patients With Bladder Cancer Responding to Immune Checkpoint Inhibitor Therapy.
Yi-Hui Pan, Jia-Xing Zhang, +5 authors, Jun-Hang Luo.
Front Immunol, 2021 Aug 24; 12. PMID: 34421886    Free PMC article.
Nivolumab in combination with cabozantinib for metastatic triple-negative breast cancer: a phase II and biomarker study.
Romualdo Barroso-Sousa, Tanya E Keenan, +13 authors, Sara M Tolaney.
NPJ Breast Cancer, 2021 Aug 27; 7(1). PMID: 34433812    Free PMC article.
The current issues and future perspective of artificial intelligence for developing new treatment strategy in non-small cell lung cancer: harmonization of molecular cancer biology and artificial intelligence.
Ichidai Tanaka, Taiki Furukawa, Masahiro Morise.
Cancer Cell Int, 2021 Aug 28; 21(1). PMID: 34446006    Free PMC article.
Effect of TTN Mutations on Immune Microenvironment and Efficacy of Immunotherapy in Lung Adenocarcinoma Patients.
Zhe Wang, Chunguang Wang, Shengcheng Lin, Xin Yu.
Front Oncol, 2021 Sep 14; 11. PMID: 34513703    Free PMC article.
Pan-Cancer Analysis of PARP1 Alterations as Biomarkers in the Prediction of Immunotherapeutic Effects and the Association of Its Expression Levels and Immunotherapy Signatures.
Xinke Zhang, Yingying Wang, +2 authors, Jiewei Chen.
Front Immunol, 2021 Sep 18; 12. PMID: 34531868    Free PMC article.
Molecular correlates of response to eribulin and pembrolizumab in hormone receptor-positive metastatic breast cancer.
Tanya E Keenan, Jennifer L Guerriero, +26 authors, Sara M Tolaney.
Nat Commun, 2021 Sep 23; 12(1). PMID: 34548479    Free PMC article.
Prognostic Role of ceRNA Network in Immune Infiltration of Hepatocellular Carcinoma.
Qianhui Xu, Shaohuai Chen, Yuanbo Hu, Wen Huang.
Front Genet, 2021 Oct 01; 12. PMID: 34589117    Free PMC article.
Identification of immune-related subtypes of colorectal cancer to improve antitumor immunotherapy.
Xiaobo Zheng, Yong Gao, +5 authors, Mingqing Xu.
Sci Rep, 2021 Oct 02; 11(1). PMID: 34593914    Free PMC article.
CD177 modulates the function and homeostasis of tumor-infiltrating regulatory T cells.
Myung-Chul Kim, Nicholas Borcherding, +32 authors, Weizhou Zhang.
Nat Commun, 2021 Oct 03; 12(1). PMID: 34599187    Free PMC article.
Identification and validation of tissue or ctDNA PTPRD phosphatase domain deleterious mutations as prognostic and predictive biomarkers for immune checkpoint inhibitors in non-squamous NSCLC.
Yiting Sun, Jianchun Duan, +10 authors, Jie Wang.
BMC Med, 2021 Oct 08; 19(1). PMID: 34615542    Free PMC article.
Prevalence and Landscape of Actionable Genomic Alterations in Renal Cell Carcinoma.
Kyrollis Attalla, Renzo G DiNatale, +17 authors, A Ari Hakimi.
Clin Cancer Res, 2021 Jul 16; 27(20). PMID: 34261695    Free PMC article.
Weighted Gene Co-expression Network Analysis Identifies a Cancer-Associated Fibroblast Signature for Predicting Prognosis and Therapeutic Responses in Gastric Cancer.
Hang Zheng, Heshu Liu, +2 authors, Xin Wang.
Front Mol Biosci, 2021 Oct 26; 8. PMID: 34692770    Free PMC article.
Improved prediction of immune checkpoint blockade efficacy across multiple cancer types.
Diego Chowell, Seong-Keun Yoo, +31 authors, Timothy A Chan.
Nat Biotechnol, 2021 Nov 03; 40(4). PMID: 34725502
Tumor-immune profiling of CT-26 and Colon 26 syngeneic mouse models reveals mechanism of anti-PD-1 response.
Yosuke Sato, Yu Fu, +2 authors, Michael H Shaw.
BMC Cancer, 2021 Nov 15; 21(1). PMID: 34774008    Free PMC article.
Sex Disparities of Genomic Determinants in Response to Immune Checkpoint Inhibitors in Melanoma.
Fuyan Shi, Wenjing Zhang, +6 authors, Qinghua Wang.
Front Immunol, 2021 Nov 20; 12. PMID: 34795662    Free PMC article.
Single-Cell RNA Sequencing Reveals the Heterogeneity of Tumor-Associated Macrophage in Non-Small Cell Lung Cancer and Differences Between Sexes.
Qi Yang, Hongman Zhang, +4 authors, Jian Zhang.
Front Immunol, 2021 Nov 23; 12. PMID: 34804043    Free PMC article.
Emerging biomarkers in metastatic urothelial carcinoma: tumour mutational burden, PD-L1 expression and APOBEC polypeptide-like signature in a patient with complete response to anti-programmed cell death protein-1 inhibitor.
Marcello Moro Queiroz, Zenaide Silva de Souza, +8 authors, Diogo Assed Bastos.
Ecancermedicalscience, 2021 Nov 27; 15. PMID: 34824629    Free PMC article.
Potential Biomarkers for the Efficacy of PD-1-PD-L Blockade in Cancer.
Miruna Grecea, Olga Soritau, +2 authors, Mihnea Zdrenghea.
Onco Targets Ther, 2021 Dec 02; 14. PMID: 34848970    Free PMC article.
Combination of Tumor Mutational Burden and Specific Gene Mutations Stratifies Outcome to Immunotherapy Across Recurrent and Metastatic Head and Neck Squamous Cell Carcinoma.
Ying-Peng Peng, Rong Wang, +5 authors, Zhi-Gang Liu.
Front Genet, 2021 Dec 07; 12. PMID: 34868231    Free PMC article.
Evaluation of 30 DNA damage response and 6 mismatch repair gene mutations as biomarkers for immunotherapy outcomes across multiple solid tumor types.
Zhe Gong, Yue Yang, Jieyun Zhang, Weijian Guo.
Cancer Biol Med, 2021 May 08;. PMID: 33960179    Free PMC article.
The developing landscape of combinatorial therapies of immune checkpoint blockade with DNA damage repair inhibitors for the treatment of breast and ovarian cancers.
Lingling Zhu, Jiewei Liu, Jiang Chen, Qinghua Zhou.
J Hematol Oncol, 2021 Dec 22; 14(1). PMID: 34930377    Free PMC article.
Cell cycle on the crossroad of tumorigenesis and cancer therapy.
Jing Liu, Yunhua Peng, Wenyi Wei.
Trends Cell Biol, 2021 Jul 27; 32(1). PMID: 34304958    Free PMC article.
Comprehensive analysis of DNA damage repair deficiency in 10,284 pan-cancer study.
Yanni Xiao, Di Lu, +11 authors, Li Yang.
Ann Transl Med, 2022 Jan 07; 9(22). PMID: 34988170    Free PMC article.
Prediction of biomarkers and therapeutic combinations for anti-PD-1 immunotherapy using the global gene network association.
Chia-Chin Wu, Y Alan Wang, +2 authors, P Andrew Futreal.
Nat Commun, 2022 Jan 12; 13(1). PMID: 35013211    Free PMC article.
Comparative Analysis of Predictive Biomarkers for PD-1/PD-L1 Inhibitors in Cancers: Developments and Challenges.
Fang Yang, Jacqueline F Wang, +2 authors, Julian R Molina.
Cancers (Basel), 2022 Jan 12; 14(1). PMID: 35008273    Free PMC article.
SNF5, a core subunit of SWI/SNF complex, regulates melanoma cancer cell growth, metastasis, and immune escape in response to matrix stiffness.
Ying Chen, Meilian Zhao, +4 authors, Liling Tang.
Transl Oncol, 2022 Jan 10; 17. PMID: 34999540    Free PMC article.
Analysis of N6-Methyladenosine Modification Patterns and Tumor Immune Microenvironment in Pancreatic Adenocarcinoma.
Yong Liu, Guangbing Li, +4 authors, Jun Liu.
Front Genet, 2022 Jan 21; 12. PMID: 35046996    Free PMC article.
Biomarkers for predicting the efficacy of immune checkpoint inhibitors.
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J Cancer, 2022 Jan 25; 13(2). PMID: 35069896    Free PMC article.
Novel Molecular Determinants of Response or Resistance to Immune Checkpoint Inhibitor Therapies in Melanoma.
Wenjing Zhang, Yujia Kong, +5 authors, Qinghua Wang.
Front Immunol, 2022 Jan 29; 12. PMID: 35087523    Free PMC article.
Inactivation of Fbxw7 Impairs dsRNA Sensing and Confers Resistance to PD-1 Blockade.
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Cancer Discov, 2020 May 07; 10(9). PMID: 32371478    Free PMC article.
Identification of neoantigens for individualized therapeutic cancer vaccines.
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Nat Rev Drug Discov, 2022 Feb 03; 21(4). PMID: 35105974    Free PMC article.
Co-occurring genomic alterations and immunotherapy efficacy in NSCLC.
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NPJ Precis Oncol, 2022 Jan 20; 6(1). PMID: 35042953    Free PMC article.
Immune checkpoint inhibitors and driver oncogenes in non-small cell lung cancer.
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Mutational landscape influences immunotherapy outcomes among patients with non-small-cell lung cancer with human leukocyte antigen supertype B44.
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Nat Cancer, 2020 Dec 01; 1(12). PMID: 35121931
Multi-omic analysis reveals significantly mutated genes and DDX3X as a sex-specific tumor suppressor in cutaneous melanoma.
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Nat Cancer, 2020 Jun 01; 1(6). PMID: 35121978    Free PMC article.
Genomics-guided pre-clinical development of cancer therapies.
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Nat Cancer, 2020 May 01; 1(5). PMID: 35121986
Discovery through clinical sequencing in oncology.
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Nat Cancer, 2020 Aug 01; 1(8). PMID: 35122052    Free PMC article.
Association of PTPRT mutations with immune checkpoint inhibitors response and outcome in melanoma and non-small cell lung cancer.
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Cancer Med, 2021 Dec 05; 11(3). PMID: 34862763    Free PMC article.
A mutation-based gene set predicts survival benefit after immunotherapy across multiple cancers and reveals the immune response landscape.
Junyu Long, Dongxu Wang, +9 authors, Haitao Zhao.
Genome Med, 2022 Feb 25; 14(1). PMID: 35197093    Free PMC article.
Prognostic and Immunological Role of FAT Family Genes in Non-Small Cell Lung Cancer.
Zhenxing Feng, Yan Yin, +4 authors, Jianwen Qin.
Cancer Control, 2022 Feb 26; 29. PMID: 35212236    Free PMC article.
Combined tumor and immune signals from genomes or transcriptomes predict outcomes of checkpoint inhibition in melanoma.
Samuel S Freeman, Moshe Sade-Feldman, +36 authors, Nir Hacohen.
Cell Rep Med, 2022 Mar 05; 3(2). PMID: 35243413    Free PMC article.
PIK3CA Gene Mutations in HNSCC: Systematic Review and Correlations with HPV Status and Patient Survival.
Daniela Cochicho, Susana Esteves, +7 authors, Ana Felix.
Cancers (Basel), 2022 Mar 11; 14(5). PMID: 35267596    Free PMC article.
Associations of HER2 Mutation With Immune-Related Features and Immunotherapy Outcomes in Solid Tumors.
Deqiang Wang, Xiaofeng Chen, +9 authors, Yongqian Shu.
Front Immunol, 2022 Mar 15; 13. PMID: 35281032    Free PMC article.
Biological and technical factors in the assessment of blood-based tumor mutational burden (bTMB) in patients with NSCLC.
Milou Schuurbiers, Zhongyun Huang, +7 authors, Daniel Klass.
J Immunother Cancer, 2022 Feb 27; 10(2). PMID: 35217576    Free PMC article.
APOBEC Mutagenesis Inhibits Breast Cancer Growth through Induction of T cell-Mediated Antitumor Immune Responses.
Ashley V DiMarco, Xiaodi Qin, +9 authors, James V Alvarez.
Cancer Immunol Res, 2021 Nov 20; 10(1). PMID: 34795033    Free PMC article.
Deleterious AHNAK2 Mutation as a Novel Biomarker for Immune Checkpoint Inhibitors in Non-Small Cell Lung Cancer.
Yanan Cui, Xinyin Liu, +4 authors, Renhua Guo.
Front Oncol, 2022 Apr 02; 12. PMID: 35359393    Free PMC article.
Serum amyloid A 1 induces suppressive neutrophils through the Toll-like receptor 2-mediated signaling pathway to promote progression of breast cancer.
Xingjian Niu, Lei Yin, +7 authors, Hongfei Ji.
Cancer Sci, 2022 Feb 02; 113(4). PMID: 35102665    Free PMC article.
Resolving genetic heterogeneity in cancer.
Samra Turajlic, Andrea Sottoriva, Trevor Graham, Charles Swanton.
Nat Rev Genet, 2019 Mar 29; 20(7). PMID: 30918367
Highly Cited. Review.
The "Great Debate" at Immunotherapy Bridge 2021, December 1st-2nd, 2021.
Paolo A Ascierto, Lisa H Butterfield, +8 authors, Patrick Hwu.
J Transl Med, 2022 Apr 23; 20(1). PMID: 35449104    Free PMC article.
Correlation of PD-L1 Expression with Clinicopathological and Genomic Features in Chinese Non-Small-Cell Lung Cancer.
Yue Li, Chong Li, +11 authors, Yuezhen Wang.
J Oncol, 2022 Apr 22; 2022. PMID: 35444698    Free PMC article.
Heterogeneity of the tumor immune microenvironment and its clinical relevance.
Qingzhu Jia, Aoyun Wang, +2 authors, Haixia Long.
Exp Hematol Oncol, 2022 Apr 25; 11(1). PMID: 35461288    Free PMC article.
Immunogenicity and therapeutic targeting of a public neoantigen derived from mutated PIK3CA.
Smita S Chandran, Jiaqi Ma, +19 authors, Christopher A Klebanoff.
Nat Med, 2022 Apr 29; 28(5). PMID: 35484264    Free PMC article.
Classification of lung adenocarcinoma based on stemness scores in bulk and single cell transcriptomes.
Qian Liu, Jiali Lei, Xiaobo Zhang, Xiaosheng Wang.
Comput Struct Biotechnol J, 2022 May 03; 20. PMID: 35495113    Free PMC article.
A sheet pocket to prevent cross-contamination of formalin-fixed paraffin-embedded block for application in next generation sequencing.
Keiichi Iwaya, Hisae Arai, +6 authors, Masayoshi Soma.
PLoS One, 2022 May 05; 17(5). PMID: 35507545    Free PMC article.
Association of KDR mutation with better clinical outcomes in pan-cancer for immune checkpoint inhibitors.
Yanan Cui, Pengpeng Zhang, +7 authors, Renhua Guo.
Am J Cancer Res, 2022 May 10; 12(4). PMID: 35530271    Free PMC article.
Toripalimab plus axitinib in patients with metastatic mucosal melanoma: 3-year survival update and biomarker analysis.
Siming Li, Xiaowen Wu, +17 authors, Xinan Sheng.
J Immunother Cancer, 2022 Feb 24; 10(2). PMID: 35193932    Free PMC article.
A Somatic Mutation Signature Predicts the Best Overall Response to Anti-programmed Cell Death Protein-1 Treatment in Epidermal Growth Factor Receptor/Anaplastic Lymphoma Kinase-Negative Non-squamous Non-small Cell Lung Cancer.
Jie Peng, Lushan Xiao, Dan Zou, Lijie Han.
Front Med (Lausanne), 2022 May 21; 9. PMID: 35592856    Free PMC article.
Estimating tumor mutational burden from RNA-sequencing without a matched-normal sample.
Rotem Katzir, Noam Rudberg, Keren Yizhak.
Nat Commun, 2022 Jun 03; 13(1). PMID: 35654823