. 2018 Sep;8(3).
doi: 10.3390/diagnostics8030060.

RNAs as Candidate Diagnostic and Prognostic Markers of Prostate Cancer-From Cell Line Models to Liquid Biopsies

Marvin C J Lim 1 Anne-Marie Baird 2 John Aird 3 John Greene 4 Dhruv Kapoor 5 Steven G Gray 6 Ray McDermott 7 Stephen P Finn 8 
  • PMID: 30200254
  •     229 References
  •     6 citations


The treatment landscape of prostate cancer has evolved rapidly over the past five years. The explosion in treatment advances has been witnessed in parallel with significant progress in the field of molecular biomarkers. The advent of next-generation sequencing has enabled the molecular profiling of the genomic and transcriptomic architecture of prostate and other cancers. Coupled with this, is a renewed interest in the role of non-coding RNA (ncRNA) in prostate cancer biology. ncRNA consists of several different classes including small non-coding RNA (sncRNA), long non-coding RNA (lncRNA), and circular RNA (circRNA). These families are under active investigation, given their essential roles in cancer initiation, development and progression. This review focuses on the evidence for the role of RNAs in prostate cancer, and their use as diagnostic and prognostic markers, and targets for treatment in this disease.

Keywords: RNA; biomarker; circRNA; lncRNA; mRNA; miRNA; ncRNA; prostate cancer; sdRNA; snoRNA; tRF; tRNA.

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Nat Rev Genet, 2011 Nov 19; 12(12). PMID: 22094949
Highly Cited. Review.
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Sci Rep, 2015 Feb 27; 5. PMID: 25715874    Free PMC article.
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Oncotarget, 2016 Mar 26; 7(17). PMID: 27015120    Free PMC article.
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Xiaohai Wang, Yongzhi Xu, +5 authors, Dongliang Xu.
Cell Prolif, 2017 Oct 11; 50(6). PMID: 28994148    Free PMC article.
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Lancet Oncol, 2012 Sep 22; 13(10). PMID: 22995653
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Wenhao Weng, Na Liu, +8 authors, Ajay Goel.
Mol Cancer, 2018 Feb 01; 17(1). PMID: 29382334    Free PMC article.
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Eur Urol, 2014 Dec 04; 68(1). PMID: 25465337
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J Hematol Oncol, 2015 Apr 22; 8. PMID: 25895683    Free PMC article.
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Nat Rev Genet, 2016 Oct 16; 17(11). PMID: 27739534    Free PMC article.
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PLoS Genet, 2013 Sep 17; 9(9). PMID: 24039610    Free PMC article.
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J Clin Oncol, 2006 May 25; 24(23). PMID: 16720680
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Highly Cited. Review.
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