Review
. 2018 Sep;8(3).
doi: 10.3390/diagnostics8030060.

RNAs as Candidate Diagnostic and Prognostic Markers of Prostate Cancer-From Cell Line Models to Liquid Biopsies

Marvin C J Lim 1 Anne-Marie Baird 2 John Aird 3 John Greene 4 Dhruv Kapoor 5 Steven G Gray 6 Ray McDermott 7 Stephen P Finn 8 
Affiliations
  • PMID: 30200254
  •     229 References
  •     6 citations

Abstract

The treatment landscape of prostate cancer has evolved rapidly over the past five years. The explosion in treatment advances has been witnessed in parallel with significant progress in the field of molecular biomarkers. The advent of next-generation sequencing has enabled the molecular profiling of the genomic and transcriptomic architecture of prostate and other cancers. Coupled with this, is a renewed interest in the role of non-coding RNA (ncRNA) in prostate cancer biology. ncRNA consists of several different classes including small non-coding RNA (sncRNA), long non-coding RNA (lncRNA), and circular RNA (circRNA). These families are under active investigation, given their essential roles in cancer initiation, development and progression. This review focuses on the evidence for the role of RNAs in prostate cancer, and their use as diagnostic and prognostic markers, and targets for treatment in this disease.

Keywords: RNA; biomarker; circRNA; lncRNA; mRNA; miRNA; ncRNA; prostate cancer; sdRNA; snoRNA; tRF; tRNA.

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Mol Cancer, 2018 Feb 02; 17(1). PMID: 29386015    Free PMC article.
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Manel Esteller.
Nat Rev Genet, 2011 Nov 19; 12(12). PMID: 22094949
Highly Cited. Review.
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Song Xu, Xiao-Ming Yi, +3 authors, Wen-Quan Zhou.
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RNA, 2009 May 29; 15(7). PMID: 19474147    Free PMC article.
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PLoS One, 2015 Oct 21; 10(10). PMID: 26485708    Free PMC article.
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Eric A Klein, Matthew R Cooperberg, +17 authors, Peter R Carroll.
Eur Urol, 2014 May 20; 66(3). PMID: 24836057
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Aaron L Sarver, Lihua Li, Subbaya Subramanian.
Cancer Res, 2010 Dec 02; 70(23). PMID: 21118966
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John R Prensner, Wei Chen, +19 authors, Felix Y Feng.
Cancer Res, 2014 Jan 30; 74(6). PMID: 24473064    Free PMC article.
Highly Cited.
SNORD76, a box C/D snoRNA, acts as a tumor suppressor in glioblastoma.
Luyue Chen, Lei Han, +8 authors, Chunsheng Kang.
Sci Rep, 2015 Feb 27; 5. PMID: 25715874    Free PMC article.
A comprehensive repertoire of tRNA-derived fragments in prostate cancer.
Michael Olvedy, Mauro Scaravilli, +3 authors, Elena S Martens-Uzunova.
Oncotarget, 2016 Mar 26; 7(17). PMID: 27015120    Free PMC article.
Cell-free circulating plasma hTERT mRNA is a useful marker for prostate cancer diagnosis and is associated with poor prognosis tumor characteristics.
José A March-Villalba, José M Martínez-Jabaloyas, +3 authors, Francisco Dasí.
PLoS One, 2012 Aug 24; 7(8). PMID: 22916267    Free PMC article.
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EMBO J, 2002 Aug 29; 21(17). PMID: 12198168    Free PMC article.
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LincRNA-p21 suppresses development of human prostate cancer through inhibition of PKM2.
Xiaohai Wang, Yongzhi Xu, +5 authors, Dongliang Xu.
Cell Prolif, 2017 Oct 11; 50(6). PMID: 28994148    Free PMC article.
The up-regulation of long non-coding RNA CCAT2 indicates a poor prognosis for prostate cancer and promotes metastasis by affecting epithelial-mesenchymal transition.
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Biochem Biophys Res Commun, 2016 Aug 26; 480(4). PMID: 27558961
Chemohormonal Therapy in Metastatic Hormone-Sensitive Prostate Cancer.
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N Engl J Med, 2015 Aug 06; 373(8). PMID: 26244877    Free PMC article.
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Abiraterone acetate for treatment of metastatic castration-resistant prostate cancer: final overall survival analysis of the COU-AA-301 randomised, double-blind, placebo-controlled phase 3 study.
Karim Fizazi, Howard I Scher, +16 authors, COU-AA-301 Investigators.
Lancet Oncol, 2012 Sep 22; 13(10). PMID: 22995653
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Novel evidence for a PIWI-interacting RNA (piRNA) as an oncogenic mediator of disease progression, and a potential prognostic biomarker in colorectal cancer.
Wenhao Weng, Na Liu, +8 authors, Ajay Goel.
Mol Cancer, 2018 Feb 01; 17(1). PMID: 29382334    Free PMC article.
A Biopsy-based 17-gene Genomic Prostate Score Predicts Recurrence After Radical Prostatectomy and Adverse Surgical Pathology in a Racially Diverse Population of Men with Clinically Low- and Intermediate-risk Prostate Cancer.
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Eur Urol, 2014 Dec 04; 68(1). PMID: 25465337
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Miguel Moyano, Giovanni Stefani.
J Hematol Oncol, 2015 Apr 22; 8. PMID: 25895683    Free PMC article.
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FEBS J, 2017 Jul 08; 284(14). PMID: 28685964
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Aurora Esquela-Kerscher, Frank J Slack.
Nat Rev Cancer, 2006 Mar 25; 6(4). PMID: 16557279
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Nucleic Acids Res, 2015 Dec 15; 44(6). PMID: 26657634    Free PMC article.
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Mol Cell, 2008 Nov 26; 32(4). PMID: 19026782
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Nat Rev Genet, 2016 Oct 16; 17(11). PMID: 27739534    Free PMC article.
Highly Cited. Review.
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Julia Salzman, Raymond E Chen, +2 authors, Patrick O Brown.
PLoS Genet, 2013 Sep 17; 9(9). PMID: 24039610    Free PMC article.
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Suman Ghosal, Shaoli Das, +2 authors, Jayprokas Chakrabarti.
Front Genet, 2013 Dec 18; 4. PMID: 24339831    Free PMC article.
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Ling-Zhi Liu, Chongyong Li, +6 authors, Bing-Hua Jiang.
PLoS One, 2011 May 06; 6(4). PMID: 21544242    Free PMC article.
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Elena S Martens-Uzunova, Youri Hoogstrate, +8 authors, Guido Jenster.
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EMBO J, 2013 May 07; 32(12). PMID: 23644382    Free PMC article.
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Hepatology, 2017 May 19; 66(4). PMID: 28520103
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Zhe Kong, Xuechao Wan, +7 authors, Yao Li.
Biochem Biophys Res Commun, 2017 Aug 03; 493(3). PMID: 28765045
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Axel Heidenreich, Patrick J Bastian, +9 authors, European Association of Urology.
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Highly Cited. Systematic Review.
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L A Selth, R Das, +14 authors, W D Tilley.
Oncogene, 2016 Jun 09; 36(1). PMID: 27270433
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Eur Urol, 2016 Aug 30; 71(4). PMID: 27568654
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Martin Spahn, Susanne Kneitz, +5 authors, Burkhard Kneitz.
Int J Cancer, 2009 Jul 09; 127(2). PMID: 19585579
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Cancer Res, 2007 Jul 10; 67(13). PMID: 17616669
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Soonmyung Paik, Gong Tang, +11 authors, Norman Wolmark.
J Clin Oncol, 2006 May 25; 24(23). PMID: 16720680
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Androgen receptor (AR) promotes clear cell renal cell carcinoma (ccRCC) migration and invasion via altering the circHIAT1/miR-195-5p/29a-3p/29c-3p/CDC42 signals.
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N Engl J Med, 2004 Dec 14; 351(27). PMID: 15591335
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J Cell Biol, 2009 Apr 01; 185(1). PMID: 19332886    Free PMC article.
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Nature, 2013 Mar 01; 495(7441). PMID: 23446346
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Highly Cited. Review.
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Adjuvant Chemotherapy Guided by a 21-Gene Expression Assay in Breast Cancer.
Joseph A Sparano, Robert J Gray, +27 authors, George W Sledge.
N Engl J Med, 2018 Jun 05; 379(2). PMID: 29860917    Free PMC article.
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Jia Cheng, Hongxia Deng, +4 authors, Junming Guo.
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Jim C Hu, Stephen B Williams, +7 authors, Stuart R Lipsitz.
Urol Oncol, 2014 Jul 16; 33(2). PMID: 25017694
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Highly Cited. Review.
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Abiraterone plus Prednisone in Metastatic, Castration-Sensitive Prostate Cancer.
Karim Fizazi, NamPhuong Tran, +13 authors, LATITUDE Investigators.
N Engl J Med, 2017 Jun 06; 377(4). PMID: 28578607
Highly Cited.
Foxo3 circular RNA retards cell cycle progression via forming ternary complexes with p21 and CDK2.
William W Du, Weining Yang, +3 authors, Burton B Yang.
Nucleic Acids Res, 2016 Feb 11; 44(6). PMID: 26861625    Free PMC article.
Highly Cited.
A Pan-cancer Analysis of the Expression and Clinical Relevance of Small Nucleolar RNAs in Human Cancer.
Jing Gong, Yajuan Li, +12 authors, Leng Han.
Cell Rep, 2017 Nov 16; 21(7). PMID: 29141226
Highly Cited.
Comprehensive characterization of tissue-specific circular RNAs in the human and mouse genomes.
Siyu Xia, Jing Feng, +8 authors, Chunjiang He.
Brief Bioinform, 2016 Aug 21; 18(6). PMID: 27543790
Highly Cited.
An updated human snoRNAome.
Hadi Jorjani, Stephanie Kehr, +5 authors, Andreas R Gruber.
Nucleic Acids Res, 2016 May 14; 44(11). PMID: 27174936    Free PMC article.
Highly Cited.
Novel dimensions of piRNAs in cancer.
Yuping Mei, David Clark, Li Mao.
Cancer Lett, 2013 Apr 23; 336(1). PMID: 23603435    Free PMC article.
Review.
A germline-specific class of small RNAs binds mammalian Piwi proteins.
Angélique Girard, Ravi Sachidanandam, Gregory J Hannon, Michelle A Carmell.
Nature, 2006 Jun 06; 442(7099). PMID: 16751776
Highly Cited.
Biallelic Inactivation of BRCA2 in Platinum-sensitive Metastatic Castration-resistant Prostate Cancer.
Heather H Cheng, Colin C Pritchard, +2 authors, Bruce Montgomery.
Eur Urol, 2016 Jan 03; 69(6). PMID: 26724258    Free PMC article.
Highly Cited.
Prospective Validation of a 21-Gene Expression Assay in Breast Cancer.
Joseph A Sparano, Robert J Gray, +28 authors, George W Sledge.
N Engl J Med, 2015 Sep 29; 373(21). PMID: 26412349    Free PMC article.
Highly Cited.
SNORD89 promotes stemness phenotype of ovarian cancer cells by regulating Notch1-c-Myc pathway.
Wenjing Zhu, Jumin Niu, +15 authors, Minjie Wei.
J Transl Med, 2019 Aug 10; 17(1). PMID: 31395064    Free PMC article.
Differential expression profiles of circRNAs in human prostate cancer based on chip and bioinformatic analysis.
Shengyang Ge, Chuanyu Sun, +4 authors, Lijie Zhu.
Int J Clin Exp Pathol, 2020 Jun 09; 13(5). PMID: 32509077    Free PMC article.
Circular RNA and its potential as prostate cancer biomarkers.
Dwayne Tucker, Wei Zheng, Da-Hong Zhang, Xuesen Dong.
World J Clin Oncol, 2020 Sep 04; 11(8). PMID: 32879844    Free PMC article.
Review.
Liquid Biopsy Potential Biomarkers in Prostate Cancer.
Jochen Neuhaus, Bo Yang.
Diagnostics (Basel), 2019 Jan 31; 8(4). PMID: 30698162    Free PMC article.
Regulation of circGOLPH3 and its binding protein CBX7 on the proliferation and apoptosis of prostate cancer cells.
Lifeng Gong, Yu Tang, +2 authors, Shengjun Luo.
Biosci Rep, 2020 Nov 28; 40(12). PMID: 33245100    Free PMC article.
Advancement and properties of circular RNAs in prostate cancer: An emerging and compelling frontier for discovering.
Hong Zhou, Xu-Dong Zheng, +11 authors, Tao Xu.
Int J Biol Sci, 2021 Feb 23; 17(2). PMID: 33613119    Free PMC article.
Review.