Journal Article
. 2018 Oct; 29(Suppl 4):iv238-iv255.
doi: 10.1093/annonc/mdy308.

Hepatocellular carcinoma: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up

A Vogel 1 A Cervantes 2 I Chau 3 B Daniele 4 J M Llovet 5 T Meyer 6 J-C Nault 7 U Neumann 8 J Ricke 9 B Sangro 10 P Schirmacher 11 C Verslype 12 C J Zech 13 D Arnold 14 E Martinelli 15 ESMO Guidelines Committee  
Affiliations
  • PMID: 30285213
  •     211 citations

No abstract available

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Advances in immunotherapy for hepatocellular carcinoma.
Bruno Sangro, Pablo Sarobe, Sandra Hervás-Stubbs, Ignacio Melero.
Nat Rev Gastroenterol Hepatol, 2021 Apr 15; 18(8). PMID: 33850328    Free PMC article.
Review.
Optimal stereotactic body radiotherapy dosage for hepatocellular carcinoma: a multicenter study.
Ting-Shi Su, Qiu-Hua Liu, +7 authors, Le-Qun Li.
Radiat Oncol, 2021 Apr 23; 16(1). PMID: 33882972    Free PMC article.
Safety and Efficacy of Degradable Starch Microspheres Transcatheter Arterial Chemoembolization as a Bridging Therapy in Patients with Early Stage Hepatocellular Carcinoma and Child-Pugh Stage B Eligible for Liver Transplant.
Roberto Minici, Michele Ammendola, +6 authors, Domenico Laganà.
Front Pharmacol, 2021 Apr 27; 12. PMID: 33897421    Free PMC article.
Safety and Efficacy of Degradable Starch Microspheres Transcatheter Arterial Chemoembolization (DSM-TACE) in the Downstaging of Intermediate-Stage Hepatocellular Carcinoma (HCC) in Patients With a Child-Pugh Score of 8-9.
Roberto Minici, Michele Ammendola, +5 authors, Domenico Laganà.
Front Pharmacol, 2021 Apr 27; 12. PMID: 33897422    Free PMC article.
Imaging features and outcomes in patients with ruptured hepatocellular carcinoma following transcatheter arterial chemoembolization: a retrospective clinical study.
Wenpeng Zhao, Xiaopu Hou, +7 authors, Changqing Li.
J Int Med Res, 2021 Apr 16; 49(4). PMID: 33853433    Free PMC article.
Comparison of liver exposure in CT-guided high-dose rate (HDR) interstitial brachytherapy versus SBRT in hepatocellular carcinoma.
Franziska Walter, Lukas Nierer, +10 authors, Stefanie Corradini.
Radiat Oncol, 2021 May 08; 16(1). PMID: 33957941    Free PMC article.
Locoregional therapy in hepatocellular carcinoma: when to start and when to stop and when to revisit.
J J X Lee, D W-M Tai, S P Choo.
ESMO Open, 2021 Apr 23; 6(3). PMID: 33887687    Free PMC article.
Review.
Sequential Systemic Treatment in Advanced Hepatocellular Carcinoma Is Able to Prolong Median Survival to More than 3 Years in a Selected Real-World Cohort.
Johann von Felden, Kathrin Karkmann, +6 authors, Kornelius Schulze.
Visc Med, 2021 May 14; 37(2). PMID: 33981749    Free PMC article.
Response prediction of hepatocellular carcinoma undergoing transcatheter arterial chemoembolization: unlocking the potential of CT texture analysis through nested decision tree models.
Jan Vosshenrich, Christoph J Zech, +5 authors, Daniel T Boll.
Eur Radiol, 2020 Dec 05; 31(6). PMID: 33274405    Free PMC article.
Mechanistic Modelling Identifies and Addresses the Risks of Empiric Concentration-Guided Sorafenib Dosing.
Warit Ruanglertboon, Michael J Sorich, Ashley M Hopkins, Andrew Rowland.
Pharmaceuticals (Basel), 2021 May 01; 14(5). PMID: 33919091    Free PMC article.
Selection of first-line systemic therapies for advanced hepatocellular carcinoma: A network meta-analysis of randomized controlled trials.
Yue Han, Wei-Hua Zhi, +3 authors, Jian-Feng Luo.
World J Gastroenterol, 2021 May 28; 27(19). PMID: 34040331    Free PMC article.
Biomarkers for hepatocellular carcinoma based on body fluids and feces.
Ming-Cheng Guan, Wei Ouyang, +9 authors, Tian Yang.
World J Gastrointest Oncol, 2021 May 28; 13(5). PMID: 34040698    Free PMC article.
Review.
The Prognostic Correlation of Heart Rate Variability at Diagnosis with Survival of Patients with Hepatocellular Carcinoma.
Ana-Maria Ciurea, Dan Ionuț Gheonea, +3 authors, Cristin Constantin Vere.
Diagnostics (Basel), 2021 Jun 03; 11(5). PMID: 34067711    Free PMC article.
Alpha-fetoprotein response at different time-points is associated with efficacy of nivolumab monotherapy for unresectable hepatocellular carcinoma.
Wei Teng, Chen-Chun Lin, +4 authors, Shi-Ming Lin.
Am J Cancer Res, 2021 Jun 08; 11(5). PMID: 34094688    Free PMC article.
Biomarkers in Hepatobiliary Cancers: What is Useful in Clinical Practice?
Alice Boilève, Marc Hilmi, +2 authors, Cindy Neuzillet.
Cancers (Basel), 2021 Jun 03; 13(11). PMID: 34070929    Free PMC article.
Review.
Peritumoral Dilation Radiomics of Gadoxetate Disodium-Enhanced MRI Excellently Predicts Early Recurrence of Hepatocellular Carcinoma without Macrovascular Invasion After Hepatectomy.
Huanhuan Chong, Yuda Gong, +4 authors, Mengsu Zeng.
J Hepatocell Carcinoma, 2021 Jun 18; 8. PMID: 34136422    Free PMC article.
Identification of m6A methyltransferase-related lncRNA signature for predicting immunotherapy and prognosis in patients with hepatocellular carcinoma.
Lili Li, Rongrong Xie, Guangrong Lu.
Biosci Rep, 2021 May 25; 41(6). PMID: 34027555    Free PMC article.
Cancer and hepatic steatosis.
R Paternostro, W Sieghart, M Trauner, M Pinter.
ESMO Open, 2021 Jun 18; 6(4). PMID: 34139486    Free PMC article.
Review.
Value of spectral detector computed tomography for the early assessment of technique efficacy after microwave ablation of hepatocellular carcinoma.
Robert Peter Reimer, Nils Große Hokamp, +8 authors, Christian Wybranski.
PLoS One, 2021 Jun 16; 16(6). PMID: 34129650    Free PMC article.
Multi-scale and multi-parametric radiomics of gadoxetate disodium-enhanced MRI predicts microvascular invasion and outcome in patients with solitary hepatocellular carcinoma ≤ 5 cm.
Huan-Huan Chong, Li Yang, +5 authors, Meng-Su Zeng.
Eur Radiol, 2021 Jan 16; 31(7). PMID: 33447861    Free PMC article.
Evaluation of Hepatocellular Carcinoma Patients: Interim Analysis of Cases from a Tertiary Referral Center in Craiova, Romania.
Ana-Maria Ciurea, Cristin Constantin Vere, +5 authors, Dan-Ionuţ Gheonea.
Curr Health Sci J, 2021 Jul 03; 47(1). PMID: 34211741    Free PMC article.
Feasibility of SBRT for hepatocellular carcinoma in Brazil - a prospective pilot study.
Andre Tsin Chih Chen, Fabio Payão, +7 authors, Flair José Carrilho.
Rep Pract Oncol Radiother, 2021 Jul 03; 26(2). PMID: 34211773    Free PMC article.
Choledocho-nodal Fistula: Uncommon Cause of Obstructive Jaundice in a Patient with HCC Diagnosed by Combined ERCP/EUS.
Mohamed H Emara, Mariam S Zaghloul, Aya M Mahros, Emad H Ema.
J Clin Imaging Sci, 2021 Jul 06; 11. PMID: 34221641    Free PMC article.
The ratio of preoperative alpha-fetoprotein level to total tumor volume as a prognostic factor of hepatocellular carcinoma after liver transplantation.
Tao Jiang, Xiao-Shi Zhang, +5 authors, Ren Lang.
Medicine (Baltimore), 2021 Jul 01; 100(26). PMID: 34190174    Free PMC article.
Pembrolizumab as Second-Line Therapy for Advanced Hepatocellular Carcinoma: A Subgroup Analysis of Asian Patients in the Phase 3 KEYNOTE-240 Trial.
Masatoshi Kudo, Ho Yeong Lim, +11 authors, Baek-Yeol Ryoo.
Liver Cancer, 2021 Jul 10; 10(3). PMID: 34239813    Free PMC article.
The Pattern of Progression Defines Post-progression Survival in Patients with Hepatocellular Carcinoma Treated with SIRT.
Manuel de la Torre-Aláez, Carlota Jordán-Iborra, +7 authors, Bruno Sangro.
Cardiovasc Intervent Radiol, 2020 Mar 14; 43(8). PMID: 32166352
An excellent nomogram predicts microvascular invasion that cannot independently stratify outcomes of small hepatocellular carcinoma.
Huanhuan Chong, Peiyun Zhou, Chun Yang, Mengsu Zeng.
Ann Transl Med, 2021 Jul 17; 9(9). PMID: 34268370    Free PMC article.
An evaluation of the reporting quality in clinical practice guidelines for hepatocellular carcinoma using the RIGHT checklist.
Haiyang Chen, Meng Tao, +9 authors, Qiming Wang.
Ann Transl Med, 2021 Jul 20; 9(12). PMID: 34277804    Free PMC article.
Application of ultrasound combined with enhanced MRI by Gd-BOPTA in diagnosing hepatocellular carcinoma.
Shuwen Ji, Ziyong Wang, Shiyong Xia.
Am J Transl Res, 2021 Jul 27; 13(6). PMID: 34306478    Free PMC article.
Hepatocellular carcinoma: a clinical and pathological overview.
Salvatore Lorenzo Renne, Samantha Sarcognato, +4 authors, Luca Di Tommaso.
Pathologica, 2021 Jul 24; 113(3). PMID: 34294938    Free PMC article.
Review.
The immunological and metabolic landscape in primary and metastatic liver cancer.
Xin Li, Pierluigi Ramadori, +3 authors, Mathias Heikenwalder.
Nat Rev Cancer, 2021 Jul 31; 21(9). PMID: 34326518
Review.
Role of ssDNA as a Noninvasive Indicator for the Diagnosis and Prognosis of Hepatocellular Carcinoma: An Exploratory Study.
Qi Zhao, Yiqiu Xu, +4 authors, Xuewen Huang.
Dis Markers, 2021 Aug 17; 2021. PMID: 34394775    Free PMC article.
Transarterial chemoembolization plus sorafenib versus sorafenib for intermediate-advanced hepatocellular carcinoma: A meta-analysis comparing clinical outcomes.
Yong Xie, Huan Tian, +4 authors, Hua Xiang.
Medicine (Baltimore), 2021 Aug 21; 100(33). PMID: 34414963    Free PMC article.
Systematic Review.
Emerging treatment modalities for systemic therapy in hepatocellular carcinoma.
Xin Qing, Wenjing Xu, +3 authors, Yewei Zhang.
Biomark Res, 2021 Aug 23; 9(1). PMID: 34419152    Free PMC article.
Review.
Microwave ablation compared with radiofrequency ablation for the treatment of liver cancer: a systematic review and meta-analysis.
Antonios E Spiliotis, Gereon Gäbelein, +3 authors, Bijendra Patel.
Radiol Oncol, 2021 Jun 25; 55(3). PMID: 34167181    Free PMC article.
Systematic Review.
Downstaging and resection of hepatocellular carcinoma in patients with extrahepatic metastases after stereotactic therapy.
Xiaobo Yang, Haifeng Xu, +13 authors, Haitao Zhao.
Hepatobiliary Surg Nutr, 2021 Aug 26; 10(4). PMID: 34430522    Free PMC article.
The Role of Immunotherapy in a Tolerogenic Environment: Current and Future Perspectives for Hepatocellular Carcinoma.
Liliana Montella, Federica Sarno, +9 authors, Gaetano Facchini.
Cells, 2021 Aug 28; 10(8). PMID: 34440678    Free PMC article.
Review.
Correlation of liver enhancement in gadoxetic acid-enhanced MRI with liver functions: a multicenter-multivendor analysis of hepatocellular carcinoma patients from SORAMIC trial.
Osman Öcal, Bora Peynircioglu, +16 authors, Max Seidensticker.
Eur Radiol, 2021 Sep 02; 32(2). PMID: 34467453    Free PMC article.
A Prospective Study of Liver Regeneration After Radiotherapy Based on a New (Su'S) Target Area Delineation.
Ting-Shi Su, Li-Qing Li, +4 authors, Le-Qun Li.
Front Oncol, 2021 Sep 14; 11. PMID: 34513671    Free PMC article.
Hepatobiliary phase signal intensity: A potential method of diagnosing HCC with atypical imaging features among LR-M observations.
Jae Hyon Park, Yong Eun Chung, +3 authors, Myeong-Jin Kim.
PLoS One, 2021 Sep 14; 16(9). PMID: 34516587    Free PMC article.
Increased Liquefactive Necrosis Formation After Transarterial Chemoembolization Combined with Molecular Targeted Agents Plus Immune Checkpoint Inhibitors for Hepatocellular Carcinoma.
Yingliang Wang, Chen Zhou, +6 authors, Bin Xiong.
Cancer Manag Res, 2021 Sep 16; 13. PMID: 34522136    Free PMC article.
Effects of surgery, chemotherapy, and radiation on hepatocellular carcinoma patients: A SEER-based study.
Kaif Qayum, Irfan Kar, +4 authors, Aliraza Syed.
Ann Med Surg (Lond), 2021 Sep 16; 69. PMID: 34522376    Free PMC article.
Therapeutic efficacy of a Dioscorea membranacea extract in a rat model of hepatocellular carcinoma: Histopathological aspects.
Vichununt Kerdput, Cheng Nilbu-Nga, +3 authors, Wisuit Pradidarcheep.
J Tradit Complement Med, 2021 Sep 16; 11(5). PMID: 34522634    Free PMC article.
Surveillance Strategy for Barcelona Clinic Liver Cancer B Hepatocellular Carcinoma Achieving Complete Response: An Individualized Risk-Based Machine Learning Study.
Qi-Feng Chen, Lin Dai, +3 authors, Ming Zhao.
Front Bioeng Biotechnol, 2021 Sep 21; 9. PMID: 34540812    Free PMC article.
Society for Immunotherapy of Cancer (SITC) clinical practice guideline on immunotherapy for the treatment of hepatocellular carcinoma.
Tim F Greten, Ghassan K Abou-Alfa, +18 authors, Ignacio Melero.
J Immunother Cancer, 2021 Sep 15; 9(9). PMID: 34518290    Free PMC article.
Senescence in HBV-, HCV- and NAFLD- Mediated Hepatocellular Carcinoma and Senotherapeutics: Current Evidence and Future Perspective.
Vassilis G Giannakoulis, Peter Dubovan, +2 authors, John Koskinas.
Cancers (Basel), 2021 Sep 29; 13(18). PMID: 34572959    Free PMC article.
Review.
Long-Term Outcomes of Personalized Stereotactic Ablative Brachytherapy for Recurrent Head and Neck Adenoid Cystic Carcinoma after Surgery or External Beam Radiotherapy: A 9-Year Study.
Yi Chen, Jinzhao Dai, +5 authors, Junjie Wang.
J Pers Med, 2021 Sep 29; 11(9). PMID: 34575616    Free PMC article.
Therapeutic Ultrasound Parameter Optimization for Drug Delivery Applied to a Murine Model of Hepatocellular Carcinoma.
Arsenii V Telichko, Huaijun Wang, +4 authors, Jeremy J Dahl.
Ultrasound Med Biol, 2020 Nov 07; 47(2). PMID: 33153807    Free PMC article.
Immune aspects of hepatocellular carcinoma: From immune markers for early detection to immunotherapy.
Ângelo Z Mattos, Jose D Debes, +2 authors, Angelo A Mattos.
World J Gastrointest Oncol, 2021 Oct 08; 13(9). PMID: 34616518    Free PMC article.
Review.
Neoadjuvant Treatment with Angiogenesis-Inhibitor Dovitinib Prior to Local Therapy in Hepatocellular Carcinoma: A Phase II Study.
F J Sherida H Woei-A-Jin, Nir I Weijl, +6 authors, Susanne Osanto.
Oncologist, 2021 Jul 13; 26(10). PMID: 34251745    Free PMC article.
Association Between Adjuvant Sorafenib and the Prognosis of Patients With Hepatocellular Carcinoma at a High Risk of Recurrence After Radical Resection.
Qingli Li, Tianqiang Song.
Front Oncol, 2021 Oct 12; 11. PMID: 34631511    Free PMC article.
YRDC Mediates the Resistance of Lenvatinib in Hepatocarcinoma Cells via Modulating the Translation of KRAS.
Jun Guo, Peng Zhu, +7 authors, Qing Li.
Front Pharmacol, 2021 Oct 19; 12. PMID: 34658879    Free PMC article.
The Emerging Influences of Alpha-Fetoprotein in the Tumorigenesis and Progression of Hepatocellular Carcinoma.
Ye Xu, Qinglong Guo, Libin Wei.
Cancers (Basel), 2021 Oct 24; 13(20). PMID: 34680245    Free PMC article.
Review.
Association between Time to Local Tumor Control and Treatment Outcomes Following Repeated Loco-Regional Treatment Session in Patients with Hepatocellular Carcinoma: A Retrospective, Single-Center Study.
Krzysztof Bartnik, Wacław Hołówko, Olgierd Rowiński.
Life (Basel), 2021 Oct 24; 11(10). PMID: 34685433    Free PMC article.
Regorafenib combined with transarterial chemoembolization for unresectable hepatocellular carcinoma: a real-world study.
Yue Han, Guang Cao, +9 authors, Yinghua Zou.
BMC Gastroenterol, 2021 Oct 22; 21(1). PMID: 34670512    Free PMC article.
Non-invasive imaging criteria for the diagnosis of hepatocellular carcinoma in non-cirrhotic patients with chronic hepatitis B.
Carlos Moctezuma-Velázquez, Sara Lewis, +5 authors, Augusto Villanueva.
JHEP Rep, 2021 Oct 30; 3(6). PMID: 34712933    Free PMC article.
Baseline Liver Function and Subsequent Outcomes in the Phase 3 REFLECT Study of Patients with Unresectable Hepatocellular Carcinoma.
Arndt Vogel, Catherine Frenette, +10 authors, Masatoshi Kudo.
Liver Cancer, 2021 Nov 02; 10(5). PMID: 34721512    Free PMC article.
A New Prognostic Algorithm Predicting HCC Recurrence in Patients With Barcelona Clinic Liver Cancer Stage B Who Received PA-TACE.
Shuyang Hu, Wei Gan, +5 authors, Xiaoqing Jiang.
Front Oncol, 2021 Nov 09; 11. PMID: 34745962    Free PMC article.
Locoregional Treatments for Bridging and Downstaging HCC to Liver Transplantation.
Laura Crocetti, Elena Bozzi, +7 authors, Roberto Cioni.
Cancers (Basel), 2021 Nov 14; 13(21). PMID: 34771720    Free PMC article.
Review.
Prediction of Early Recurrence After Surgery for Liver Tumor (ERASL): An International Validation of the ERASL Risk Models.
Berend R Beumer, Kosei Takagi, +6 authors, Jan N M IJzermans.
Ann Surg Oncol, 2021 Jul 09; 28(13). PMID: 34235600    Free PMC article.
The Therapeutic Effect of Myrrh (Commiphora molmol) and Doxorubicin on Diethylnitrosamine Induced Hepatocarcinogenesis in Male Albino Rats.
Hend Mohamed Anwar, Asmaa M Moghazy, Amany Abd Elhameid Osman, Amina A S Abdel Rahman.
Asian Pac J Cancer Prev, 2021 Jul 29; 22(7). PMID: 34319038    Free PMC article.
Interventional Radiology Image-Guided Locoregional Therapies (LRTs) and Immunotherapy for the Treatment of HCC.
Pierpaolo Biondetti, Lorenzo Saggiante, +6 authors, Gianpaolo Carrafiello.
Cancers (Basel), 2021 Nov 28; 13(22). PMID: 34830949    Free PMC article.
Review.
The role of NK cells in oncolytic viral therapy: a focus on hepatocellular carcinoma.
Frazer Warricker, Salim I Khakoo, Matthew D Blunt.
J Transl Genet Genom, 2021 Dec 11; 5. PMID: 34888493    Free PMC article.
Revisiting Hepatic Artery Infusion Chemotherapy in the Treatment of Advanced Hepatocellular Carcinoma.
Ching-Tso Chen, Tsung-Hao Liu, +3 authors, Zhong-Zhe Lin.
Int J Mol Sci, 2021 Dec 11; 22(23). PMID: 34884684    Free PMC article.
Review.
A retrospective study of distribution of HIV associated malignancies among inpatients from 2007 to 2020 in China.
Fang Wang, Pan Xiang, +11 authors, Fujie Zhang.
Sci Rep, 2021 Dec 23; 11(1). PMID: 34934097    Free PMC article.
Is There Still a Place for Tyrosine Kinase Inhibitors for the Treatment of Hepatocellular Carcinoma at the Time of Immunotherapies? A Focus on Lenvatinib.
Marie Decraecker, Caroline Toulouse, Jean-Frédéric Blanc.
Cancers (Basel), 2021 Dec 25; 13(24). PMID: 34944930    Free PMC article.
Review.
Combination of Ablation and Immunotherapy for Hepatocellular Carcinoma: Where We Are and Where to Go.
Kunpeng Wang, Cong Wang, +4 authors, Chong Jin.
Front Immunol, 2022 Jan 04; 12. PMID: 34975896    Free PMC article.
Review.
Liver Transplantation in Hepatocellular Carcinoma: Experiences from the Shiraz Transplant Center.
A Dastyar, H Nikoupour, +9 authors, S Nikeghbalian.
Int J Organ Transplant Med, 2022 Jan 07; 12(2). PMID: 34987736    Free PMC article.
Clinical application of advances and innovation in radiation treatment of hepatocellular carcinoma.
Valerie J W Tong, Vishal G Shelat, Yew Kuo Chao.
J Clin Transl Res, 2022 Jan 07; 7(6). PMID: 34988334    Free PMC article.
Review.
Clinical Evaluation of Ramucirumab for the Treatment of Hepatocellular Carcinoma (HCC): Place in Therapy.
Khalil Choucair, Syed Kamran, Anwaar Saeed.
Onco Targets Ther, 2022 Jan 11; 14. PMID: 35002257    Free PMC article.
Review.
Hepatocellular Carcinoma With Portal Vein Tumor Thrombus Treated With Transarterial Chemoembolization and Sorafenib vs. 125Iodine Implantation.
Hong-Tao Hu, Jun-Peng Luo, +12 authors, Hai-Liang Li.
Front Oncol, 2022 Jan 11; 11. PMID: 35004330    Free PMC article.
LPCAT1 functions as a novel prognostic molecular marker in hepatocellular carcinoma.
Hongbin Zhang, Ke Xu, +15 authors, Tingxiu Xiang.
Genes Dis, 2020 Jul 21; 9(1). PMID: 35005115    Free PMC article.
Disease control and failure patterns of unresectable hepatocellular carcinoma following transarterial radioembolization with yttrium-90 microspheres and with/without sorafenib.
Ajalaya Teyateeti, Armeen Mahvash, +9 authors, Srinivas Cheenu Kappadath.
World J Gastroenterol, 2022 Jan 25; 27(47). PMID: 35068861    Free PMC article.
Combined treatments in hepatocellular carcinoma: Time to put them in the guidelines?
Zeno Sparchez, Pompilia Radu, +6 authors, Jean-François Dufour.
World J Gastrointest Oncol, 2022 Jan 25; 13(12). PMID: 35070032    Free PMC article.
Review.
Prediction of late recurrence after radiofrequency ablation of HBV-related hepatocellular carcinoma with the age-male-albumin-bilirubin-platelets (aMAP) risk score: a multicenter study.
Yujing Xin, Xinyuan Zhang, +4 authors, Xiao Li.
J Gastrointest Oncol, 2022 Jan 25; 12(6). PMID: 35070419    Free PMC article.
Differential Diagnosis of Hepatic Mass with Central Scar: Focal Nodular Hyperplasia Mimicking Fibrolamellar Hepatocellular Carcinoma.
Teodoro Rudolphi-Solero, Eva María Triviño-Ibáñez, +6 authors, Antonio Rodríguez-Fernández.
Diagnostics (Basel), 2022 Jan 22; 12(1). PMID: 35054211    Free PMC article.
Comparison of clinical outcome between stereotactic body radiotherapy and radiofrequency ablation for unresectable hepatocellular carcinoma.
Ren Ji, Kelvin K Ng, +8 authors, Chung-Mau Lo.
Medicine (Baltimore), 2022 Jan 29; 101(4). PMID: 35089192    Free PMC article.
Safety and Efficacy of Transarterial Chemoembolization Combined With Immune Checkpoint Inhibitors and Tyrosine Kinase Inhibitors for Hepatocellular Carcinoma.
Fei Yang, Jun Yang, +8 authors, Xiao-Li Zhu.
Front Oncol, 2022 Feb 01; 11. PMID: 35096555    Free PMC article.
Impact of Platelet Count on Perioperative Bleeding in Patients With Cirrhosis Undergoing Surgical Treatments of Liver Cancer.
Vincenzo Ronca, Matteo Barabino, +8 authors, Gian Marco Podda.
Hepatol Commun, 2021 Oct 31; 6(2). PMID: 34716696    Free PMC article.
Prognostic effect of systemic inflammation in patients undergoing surgery for hepatocellular carcinoma: comparison of composite ratios and cumulative scores.
Xin Wu, Zhirong Sun, Yun Zhu.
Transl Cancer Res, 2020 Oct 01; 9(10). PMID: 35117226    Free PMC article.
Post-treatment three-dimensional voxel-based dosimetry after Yttrium-90 resin microsphere radioembolization in HCC.
Emile B Veenstra, Simeon J S Ruiter, +3 authors, Walter Noordzij.
EJNMMI Res, 2022 Feb 06; 12(1). PMID: 35122166    Free PMC article.
Understanding the patient experience in hepatocellular carcinoma: a qualitative patient interview study.
Nikunj Patel, Joshua Maher, +11 authors, Gordon Cohen.
Qual Life Res, 2021 Jun 12; 31(2). PMID: 34115280    Free PMC article.
BCLC strategy for prognosis prediction and treatment recommendation: The 2022 update.
Maria Reig, Alejandro Forner, +13 authors, Jordi Bruix.
J Hepatol, 2021 Nov 22; 76(3). PMID: 34801630    Free PMC article.
Review.
Precision Medicine for Hepatocellular Carcinoma: Clinical Perspective.
Danijel Galun, Dragana Mijac, +3 authors, Dragan Masulovic.
J Pers Med, 2022 Feb 26; 12(2). PMID: 35207638    Free PMC article.
Review.
Multiple Light-Activated Photodynamic Therapy of Tetraphenylethylene Derivative with AIE Characteristics for Hepatocellular Carcinoma via Dual-Organelles Targeting.
Chuxing Chai, Tao Zhou, +7 authors, Chidan Wan.
Pharmaceutics, 2022 Feb 27; 14(2). PMID: 35214196    Free PMC article.
Advances in Nanoliposomes for the Diagnosis and Treatment of Liver Cancer.
Yitong Li, Ruihang Zhang, Zhen Xu, Zhicheng Wang.
Int J Nanomedicine, 2022 Mar 08; 17. PMID: 35250267    Free PMC article.
Review.
Mutational signatures and processes in hepatobiliary cancers.
Ekaterina Zhuravleva, Colm J O'Rourke, Jesper B Andersen.
Nat Rev Gastroenterol Hepatol, 2022 Mar 12; 19(6). PMID: 35273358
Review.
68Ga-PSMA-11 PET/CT Improves Tumor Detection and Impacts Management in Patients with Hepatocellular Carcinoma.
Nader Hirmas, Catherine Leyh, +12 authors, Wolfgang P Fendler.
J Nucl Med, 2021 Jan 30; 62(9). PMID: 33509970    Free PMC article.
A national dose analysis of guided tumor destruction: influence of sex, age, localization and destruction technique used.
Matthieu Rojo, Aymeric Hamard, +4 authors, Julien Frandon.
Quant Imaging Med Surg, 2022 Mar 15; 12(3). PMID: 35284251    Free PMC article.
Hepatocellular carcinoma with complete response to the immunotherapy: the oncologist's dilemma.
Mansour Al-Moundhri, Antonio Cubisino, Fabrizio Panaro.
Hepatobiliary Surg Nutr, 2022 Mar 15; 11(1). PMID: 35284505    Free PMC article.
Lenvatinib Plus Camrelizumab vs. Lenvatinib Monotherapy as First-Line Treatment for Unresectable Hepatocellular Carcinoma: A Multicenter Retrospective Cohort Study.
Qi Li, Mengran Cao, +9 authors, Jinzhang Chen.
Front Oncol, 2022 Mar 15; 12. PMID: 35280760    Free PMC article.
Scoring systems for the management of oncological hepato-pancreato-biliary patients.
Alexander W Coombs, Chloe Jordan, Sabba A Hussain, Omar Ghandour.
Ann Hepatobiliary Pancreat Surg, 2022 Feb 28; 26(1). PMID: 35220286    Free PMC article.
Review.
Transarterial Chemoembolization Combined With Immune Checkpoint Inhibitors and Tyrosine Kinase Inhibitors for Unresectable Hepatocellular Carcinoma: Efficacy and Systemic Immune Response.
Fei Yang, Gui-Li Xu, +10 authors, Xiao-Li Zhu.
Front Immunol, 2022 Mar 19; 13. PMID: 35300339    Free PMC article.
Real-world efficiency of lenvatinib plus PD-1 blockades in advanced hepatocellular carcinoma: an exploration for expanded indications.
Xuqi Sun, Qi Zhang, +3 authors, Tingbo Liang.
BMC Cancer, 2022 Mar 21; 22(1). PMID: 35305593    Free PMC article.
A Novel Multimodal Radiomics Model for Predicting Prognosis of Resected Hepatocellular Carcinoma.
Ying He, Bin Hu, +7 authors, Xianjun Zhou.
Front Oncol, 2022 Mar 25; 12. PMID: 35321432    Free PMC article.
The Role of LSD1 and LSD2 in Cancers of the Gastrointestinal System: An Update.
Gianluca Malagraba, Mahdieh Yarmohammadi, +2 authors, Teresa Rubio-Tomás.
Biomolecules, 2022 Mar 26; 12(3). PMID: 35327654    Free PMC article.
Review.
Multimarker Panels for Detection of Early Stage Hepatocellular Carcinoma: A Prospective, Multicenter, Case-Control Study.
Teerha Piratvisuth, Tawesak Tanwandee, +8 authors, Henry Lik-Yuen Chan.
Hepatol Commun, 2021 Nov 20; 6(4). PMID: 34796691    Free PMC article.
Cost-Effectiveness Analysis of Follow-Up Schedule for Hepatocellular Carcinoma after Radiofrequency Ablation.
Shuifang Hu, Xiaoxue Wu, +6 authors, Zhenwei Peng.
J Oncol, 2022 Mar 30; 2022. PMID: 35345515    Free PMC article.
Efficacy of Drug-Eluting Beads Transarterial Chemoembolization Plus Camrelizumab Compared With Conventional Transarterial Chemoembolization Plus Camrelizumab for Unresectable Hepatocellular Carcinoma.
Yanqiao Ren, Yusheng Guo, +6 authors, Chuansheng Zheng.
Cancer Control, 2022 Mar 29; 29. PMID: 35343254    Free PMC article.
Randomized Phase 3 LEAP-012 Study: Transarterial Chemoembolization With or Without Lenvatinib Plus Pembrolizumab for Intermediate-Stage Hepatocellular Carcinoma Not Amenable to Curative Treatment.
Josep M Llovet, Arndt Vogel, +8 authors, Masatoshi Kudo.
Cardiovasc Intervent Radiol, 2022 Feb 05; 45(4). PMID: 35119481    Free PMC article.
Effects of Stereotactic Body Radiation Therapy Plus PD-1 Inhibitors for Patients With Transarterial Chemoembolization Refractory.
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Front Oncol, 2022 Apr 08; 12. PMID: 35387113    Free PMC article.
Systemic Therapy for Hepatocellular Carcinoma: Current Updates and Outlook.
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J Hepatocell Carcinoma, 2022 Apr 08; 9. PMID: 35388357    Free PMC article.
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Tenofovir vs. Entecavir on Outcomes of Hepatitis B Virus-Related Hepatocellular Carcinoma after Radiofrequency Ablation.
Zili Hu, Huilan Zeng, +5 authors, Zhongguo Zhou.
Viruses, 2022 Apr 24; 14(4). PMID: 35458386    Free PMC article.
Molecular pathogenesis and systemic therapies for hepatocellular carcinoma.
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Nat Cancer, 2022 Apr 29; 3(4). PMID: 35484418    Free PMC article.
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Indirect Comparisons via Sorafenib for the Comparative Effectiveness of Two PD-1/PD-L1 Inhibitors to Treat Advanced Hepatocellular Carcinoma Patients without Prior Systemic Therapies.
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Clin Epidemiol, 2022 May 07; 14. PMID: 35520275    Free PMC article.
Chimeric HDAC and the cytoskeleton inhibitor broxbam as a novel therapeutic strategy for liver cancer.
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Int J Oncol, 2022 Apr 30; 60(6). PMID: 35485292    Free PMC article.
Muscarinic Receptors Associated with Cancer.
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Cancers (Basel), 2022 May 15; 14(9). PMID: 35565451    Free PMC article.
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Identification and Validation of Novel Biomarkers for Hepatocellular Carcinoma, Liver Fibrosis/Cirrhosis and Chronic Hepatitis B via Transcriptome Sequencing Technology.
Dandan Zhao, Xiaoxiao Zhang, +16 authors, Yuemin Nan.
J Hepatocell Carcinoma, 2022 May 21; 9. PMID: 35592243    Free PMC article.
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Philip Johnson, Qing Zhou, Doan Y Dao, Y M Dennis Lo.
Nat Rev Gastroenterol Hepatol, 2022 Jun 09;. PMID: 35676420
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