Journal Article
. 2018 Oct; 42(12):1636-1646.
doi: 10.1097/PAS.0000000000001151.

Impact of Deep Learning Assistance on the Histopathologic Review of Lymph Nodes for Metastatic Breast Cancer

David F Steiner 1 Robert MacDonald 1 Yun Liu 1 Peter Truszkowski 1 Jason D Hipp 1 Christopher Gammage 1 Florence Thng 2 Lily Peng 1 Martin C Stumpe 1 
Affiliations
  • PMID: 30312179
  •     23 References
  •     73 citations

Abstract

Advances in the quality of whole-slide images have set the stage for the clinical use of digital images in anatomic pathology. Along with advances in computer image analysis, this raises the possibility for computer-assisted diagnostics in pathology to improve histopathologic interpretation and clinical care. To evaluate the potential impact of digital assistance on interpretation of digitized slides, we conducted a multireader multicase study utilizing our deep learning algorithm for the detection of breast cancer metastasis in lymph nodes. Six pathologists reviewed 70 digitized slides from lymph node sections in 2 reader modes, unassisted and assisted, with a wash-out period between sessions. In the assisted mode, the deep learning algorithm was used to identify and outline regions with high likelihood of containing tumor. Algorithm-assisted pathologists demonstrated higher accuracy than either the algorithm or the pathologist alone. In particular, algorithm assistance significantly increased the sensitivity of detection for micrometastases (91% vs. 83%, P=0.02). In addition, average review time per image was significantly shorter with assistance than without assistance for both micrometastases (61 vs. 116 s, P=0.002) and negative images (111 vs. 137 s, P=0.018). Lastly, pathologists were asked to provide a numeric score regarding the difficulty of each image classification. On the basis of this score, pathologists considered the image review of micrometastases to be significantly easier when interpreted with assistance (P=0.0005). Utilizing a proof of concept assistant tool, this study demonstrates the potential of a deep learning algorithm to improve pathologist accuracy and efficiency in a digital pathology workflow.

Deep learning.
Yann LeCun, Yoshua Bengio, Geoffrey Hinton.
Nature, 2015 May 29; 521(7553). PMID: 26017442
Highly Cited. Review.
Recommendations for human epidermal growth factor receptor 2 testing in breast cancer: American Society of Clinical Oncology/College of American Pathologists clinical practice guideline update.
Antonio C Wolff, M Elizabeth H Hammond, +19 authors, College of American Pathologists.
J Clin Oncol, 2013 Oct 09; 31(31). PMID: 24101045
Highly Cited.
Assisted primary screening using the automated ThinPrep Imaging System.
Charles V Biscotti, Andrea E Dawson, +4 authors, Lisa Wills-Frank.
Am J Clin Pathol, 2005 Apr 22; 123(2). PMID: 15842055
Diagnostic Assessment of Deep Learning Algorithms for Detection of Lymph Node Metastases in Women With Breast Cancer.
Babak Ehteshami Bejnordi, Mitko Veta, +67 authors, Rui Venâncio.
JAMA, 2017 Dec 14; 318(22). PMID: 29234806    Free PMC article.
Highly Cited.
Protocol for the examination of specimens from patients with invasive carcinoma of the breast.
Susan C Lester, Shikha Bose, +12 authors, Members of the Cancer Committee, College of American Pathologists.
Arch Pathol Lab Med, 2009 Oct 02; 133(10). PMID: 19792042
Prognostic impact of isolated tumor cells in breast cancer axillary nodes: single tumor cell(s) versus tumor cell cluster(s) and microanatomic location.
Johanna H Vestjens, Maaike de Boer, +6 authors, Vivianne C Tjan-Heijnen.
Breast Cancer Res Treat, 2011 Sep 20; 131(2). PMID: 21927853
The Becton Dickinson FocalPoint GS Imaging System: clinical trials demonstrate significantly improved sensitivity for the detection of important cervical lesions.
David C Wilbur, W Stephen Black-Schaffer, +4 authors, William D Tench.
Am J Clin Pathol, 2009 Oct 23; 132(5). PMID: 19846820
Effect of occult metastases on survival in node-negative breast cancer.
Donald L Weaver, Takamaru Ashikaga, +6 authors, Norman Wolmark.
N Engl J Med, 2011 Jan 21; 364(5). PMID: 21247310    Free PMC article.
Breast cancer prognosis and occult lymph node metastases, isolated tumor cells, and micrometastases.
M de Boer, J A A M van Dijck, +2 authors, V C G Tjan-Heijnen.
J Natl Cancer Inst, 2010 Mar 02; 102(6). PMID: 20190185
Systematic Review.
Computer aids and human second reading as interventions in screening mammography: two systematic reviews to compare effects on cancer detection and recall rate.
Paul Taylor, Henry W W Potts.
Eur J Cancer, 2008 Mar 21; 44(6). PMID: 18353630
Review.
21(st) century workflow: A proposal.
Jeffrey L Fine.
J Pathol Inform, 2014 Dec 24; 5(1). PMID: 25535592    Free PMC article.
Deep learning as a tool for increased accuracy and efficiency of histopathological diagnosis.
Geert Litjens, Clara I Sánchez, +7 authors, Jeroen van der Laak.
Sci Rep, 2016 May 24; 6. PMID: 27212078    Free PMC article.
Highly Cited.
Axillary dissection vs no axillary dissection in women with invasive breast cancer and sentinel node metastasis: a randomized clinical trial.
Armando E Giuliano, Kelly K Hunt, +7 authors, Monica Morrow.
JAMA, 2011 Feb 10; 305(6). PMID: 21304082    Free PMC article.
Highly Cited.
Multi-reader multi-case studies using the area under the receiver operator characteristic curve as a measure of diagnostic accuracy: systematic review with a focus on quality of data reporting.
Thaworn Dendumrongsup, Andrew A Plumb, +3 authors, Susan Mallett.
PLoS One, 2014 Dec 30; 9(12). PMID: 25541977    Free PMC article.
Systematic Review.
Sentinel node micrometastasis in breast carcinoma may not be an indication for complete axillary dissection.
Heather Rutledge, Joseph Davis, +4 authors, Luis Samayoa.
Mod Pathol, 2005 Mar 12; 18(6). PMID: 15761490
Not Just Digital Pathology, Intelligent Digital Pathology.
Balazs Acs, David L Rimm.
JAMA Oncol, 2018 Feb 03; 4(3). PMID: 29392271
Diagnostic Efficiency in Digital Pathology: A Comparison of Optical Versus Digital Assessment in 510 Surgical Pathology Cases.
Anne M Mills, Sarah E Gradecki, +5 authors, Helen P Cathro.
Am J Surg Pathol, 2017 Sep 07; 42(1). PMID: 28877052
Micrometastases or isolated tumor cells and the outcome of breast cancer.
Maaike de Boer, Carolien H M van Deurzen, +9 authors, Vivianne C G Tjan-Heijnen.
N Engl J Med, 2009 Aug 14; 361(7). PMID: 19675329
Highly Cited.
Sentinel Lymph Node in Breast Cancer: Review Article from a Pathologist's Point of View.
Sophia K Apple.
J Pathol Transl Med, 2016 Jan 13; 50(2). PMID: 26757203    Free PMC article.
Review.
Whole Slide Imaging Versus Microscopy for Primary Diagnosis in Surgical Pathology: A Multicenter Blinded Randomized Noninferiority Study of 1992 Cases (Pivotal Study).
Sanjay Mukhopadhyay, Michael D Feldman, +31 authors, Clive R Taylor.
Am J Surg Pathol, 2017 Sep 30; 42(1). PMID: 28961557    Free PMC article.
Unintended Consequences of Machine Learning in Medicine.
Federico Cabitza, Raffaele Rasoini, Gian Franco Gensini.
JAMA, 2017 Jul 21; 318(6). PMID: 28727867
Highly Cited.
Evaluating imaging and computer-aided detection and diagnosis devices at the FDA.
Brandon D Gallas, Heang-Ping Chan, +10 authors, Margarita L Zuley.
Acad Radiol, 2012 Feb 07; 19(4). PMID: 22306064    Free PMC article.
Observer variability in the interpretation of HER2/neu immunohistochemical expression with unaided and computer-aided digital microscopy.
Marios A Gavrielides, Brandon D Gallas, +2 authors, Stephen M Hewitt.
Arch Pathol Lab Med, 2011 Feb 03; 135(2). PMID: 21284444    Free PMC article.
Development and validation of a deep learning algorithm for improving Gleason scoring of prostate cancer.
Kunal Nagpal, Davis Foote, +16 authors, Martin C Stumpe.
NPJ Digit Med, 2019 Jul 16; 2. PMID: 31304394    Free PMC article.
Highly Cited.
Computational pathology definitions, best practices, and recommendations for regulatory guidance: a white paper from the Digital Pathology Association.
Esther Abels, Liron Pantanowitz, +9 authors, Cleopatra Kozlowski.
J Pathol, 2019 Jul 30; 249(3). PMID: 31355445    Free PMC article.
Review.
Artificial intelligence in digital pathology - new tools for diagnosis and precision oncology.
Kaustav Bera, Kurt A Schalper, +2 authors, Anant Madabhushi.
Nat Rev Clin Oncol, 2019 Aug 11; 16(11). PMID: 31399699    Free PMC article.
Highly Cited. Review.
Translational AI and Deep Learning in Diagnostic Pathology.
Ahmed Serag, Adrian Ion-Margineanu, +5 authors, Peter Hamilton.
Front Med (Lausanne), 2019 Oct 22; 6. PMID: 31632973    Free PMC article.
Review.
Key challenges for delivering clinical impact with artificial intelligence.
Christopher J Kelly, Alan Karthikesalingam, +2 authors, Dominic King.
BMC Med, 2019 Oct 31; 17(1). PMID: 31665002    Free PMC article.
Highly Cited.
Deep-UV excitation fluorescence microscopy for detection of lymph node metastasis using deep neural network.
Tatsuya Matsumoto, Hirohiko Niioka, +9 authors, Tetsuro Takamatsu.
Sci Rep, 2019 Nov 16; 9(1). PMID: 31729459    Free PMC article.
Impact of a deep learning assistant on the histopathologic classification of liver cancer.
Amirhossein Kiani, Bora Uyumazturk, +18 authors, Jeanne Shen.
NPJ Digit Med, 2020 Mar 07; 3. PMID: 32140566    Free PMC article.
Successful Identification of Nasopharyngeal Carcinoma in Nasopharyngeal Biopsies Using Deep Learning.
Wen-Yu Chuang, Shang-Hung Chang, +12 authors, Chao-Yuan Yeh.
Cancers (Basel), 2020 Feb 27; 12(2). PMID: 32098314    Free PMC article.
Tabu Search and Machine-Learning Classification of Benign and Malignant Proliferative Breast Lesions.
Habib Dhahri, Ines Rahmany, +2 authors, Wail Elkilani.
Biomed Res Int, 2020 Apr 08; 2020. PMID: 32258124    Free PMC article.
Review.
Emerging role of deep learning-based artificial intelligence in tumor pathology.
Yahui Jiang, Meng Yang, +2 authors, Yan Sun.
Cancer Commun (Lond), 2020 Apr 12; 40(4). PMID: 32277744    Free PMC article.
Review.
Atlas-based auto-segmentation for postoperative radiotherapy planning in endometrial and cervical cancers.
Nalee Kim, Jee Suk Chang, Yong Bae Kim, Jin Sung Kim.
Radiat Oncol, 2020 May 15; 15(1). PMID: 32404123    Free PMC article.
Automated quantitative analysis of Ki-67 staining and HE images recognition and registration based on whole tissue sections in breast carcinoma.
Min Feng, Yang Deng, +10 authors, Hong Bu.
Diagn Pathol, 2020 May 31; 15(1). PMID: 32471471    Free PMC article.
Development and Validation of a Deep Learning Model for Non-Small Cell Lung Cancer Survival.
Yunlang She, Zhuochen Jin, +9 authors, Chang Chen.
JAMA Netw Open, 2020 Jun 04; 3(6). PMID: 32492161    Free PMC article.
Impact of pre-analytical variables on deep learning accuracy in histopathology.
Andrew D Jones, John Paul Graff, +8 authors, Hooman H Rashidi.
Histopathology, 2019 Feb 26; 75(1). PMID: 30801768    Free PMC article.
Deep Learning for the Classification of Small-Cell and Non-Small-Cell Lung Cancer.
Mark Kriegsmann, Christian Haag, +18 authors, Katharina Kriegsmann.
Cancers (Basel), 2020 Jun 21; 12(6). PMID: 32560475    Free PMC article.
Development and Validation of a Deep Learning Algorithm for Gleason Grading of Prostate Cancer From Biopsy Specimens.
Kunal Nagpal, Davis Foote, +23 authors, Craig H Mermel.
JAMA Oncol, 2020 Jul 24; 6(9). PMID: 32701148    Free PMC article.
Artificial intelligence in digital breast pathology: Techniques and applications.
Asmaa Ibrahim, Paul Gamble, +4 authors, Emad A Rakha.
Breast, 2020 Jan 15; 49. PMID: 31935669    Free PMC article.
Review.
Automatic detection of squamous cell carcinoma metastasis in esophageal lymph nodes using semantic segmentation.
Yi Pan, Zhuo Sun, +13 authors, Shuangmei Zou.
Clin Transl Med, 2020 Jul 30; 10(3). PMID: 32722861    Free PMC article.
Construction and Utilization of a Neural Network Model to Predict Current Procedural Terminology Codes from Pathology Report Texts.
Jay J Ye.
J Pathol Inform, 2019 May 07; 10. PMID: 31057982    Free PMC article.
Identification of Gastritis Subtypes by Convolutional Neuronal Networks on Histological Images of Antrum and Corpus Biopsies.
Georg Steinbuss, Katharina Kriegsmann, Mark Kriegsmann.
Int J Mol Sci, 2020 Sep 17; 21(18). PMID: 32932860    Free PMC article.
Deep Learning Reveals Cancer Metastasis and Therapeutic Antibody Targeting in the Entire Body.
Chenchen Pan, Oliver Schoppe, +24 authors, Ali Ertürk.
Cell, 2019 Dec 14; 179(7). PMID: 31835038    Free PMC article.
Machine learning for endoleak detection after endovascular aortic repair.
Salmonn Talebi, Mohammad H Madani, +6 authors, Mohammad R K Mofrad.
Sci Rep, 2020 Oct 29; 10(1). PMID: 33110113    Free PMC article.
TzanckNet: a convolutional neural network to identify cells in the cytology of erosive-vesiculobullous diseases.
Mehmet Alican Noyan, Murat Durdu, Ali Haydar Eskiocak.
Sci Rep, 2020 Oct 29; 10(1). PMID: 33110197    Free PMC article.
Integrative Data Augmentation with U-Net Segmentation Masks Improves Detection of Lymph Node Metastases in Breast Cancer Patients.
Yong Won Jin, Shuo Jia, Ahmed Bilal Ashraf, Pingzhao Hu.
Cancers (Basel), 2020 Oct 16; 12(10). PMID: 33053723    Free PMC article.
AI in the treatment of fertility: key considerations.
Jason Swain, Matthew Tex VerMilyea, +2 authors, Fertility AI Forum Group.
J Assist Reprod Genet, 2020 Sep 30; 37(11). PMID: 32989510    Free PMC article.
Evaluation of the Use of Combined Artificial Intelligence and Pathologist Assessment to Review and Grade Prostate Biopsies.
David F Steiner, Kunal Nagpal, +18 authors, Craig H Mermel.
JAMA Netw Open, 2020 Nov 13; 3(11). PMID: 33180129    Free PMC article.
Rapid Trust Calibration through Interpretable and Uncertainty-Aware AI.
Richard Tomsett, Alun Preece, +5 authors, Lance Kaplan.
Patterns (N Y), 2020 Nov 19; 1(4). PMID: 33205113    Free PMC article.
Review.
Digital Pathology: Advantages, Limitations and Emerging Perspectives.
Stephan W Jahn, Markus Plass, Farid Moinfar.
J Clin Med, 2020 Nov 22; 9(11). PMID: 33217963    Free PMC article.
Review.
Deep learning and manual assessment show that the absolute mitotic count does not contain prognostic information in triple negative breast cancer.
Maschenka C A Balkenhol, Peter Bult, +4 authors, Jeroen A W M van der Laak.
Cell Oncol (Dordr), 2019 Apr 17; 42(4). PMID: 30989469
Deep neural network models for computational histopathology: A survey.
Chetan L Srinidhi, Ozan Ciga, Anne L Martel.
Med Image Anal, 2020 Oct 14; 67. PMID: 33049577    Free PMC article.
Review.
Comparing Deep Learning and Immunohistochemistry in Determining the Site of Origin for Well-Differentiated Neuroendocrine Tumors.
Jordan Redemann, Fred A Schultz, +4 authors, Joshua A Hanson.
J Pathol Inform, 2020 Dec 22; 11. PMID: 33343993    Free PMC article.
Progress of Artificial Intelligence in Gynecological Malignant Tumors.
Jie Zhou, Zhi Ying Zeng, Li Li.
Cancer Manag Res, 2020 Dec 29; 12. PMID: 33364831    Free PMC article.
Review.
Deployment of artificial intelligence for radiographic diagnosis of COVID-19 pneumonia in the emergency department.
Morgan Carlile, Brian Hurt, +3 authors, Christian Dameff.
J Am Coll Emerg Physicians Open, 2021 Jan 05; 1(6). PMID: 33392549    Free PMC article.
Automated segmentation of endometrial cancer on MR images using deep learning.
Erlend Hodneland, Julie A Dybvik, +9 authors, Ingfrid Haldorsen.
Sci Rep, 2021 Jan 10; 11(1). PMID: 33420205    Free PMC article.
Deep learning system for lymph node quantification and metastatic cancer identification from whole-slide pathology images.
Yajie Hu, Feng Su, +6 authors, Yu Sun.
Gastric Cancer, 2021 Jan 24; 24(4). PMID: 33484355
Pathway-Based Drug-Repurposing Schemes in Cancer: The Role of Translational Bioinformatics.
Enrique Hernández-Lemus, Mireya Martínez-García.
Front Oncol, 2021 Feb 02; 10. PMID: 33520715    Free PMC article.
Review.
Automated software-assisted diagnosis of esophageal squamous cell neoplasia using high-resolution microendoscopy.
Mimi C Tan, Sheena Bhushan, +10 authors, Sharmila Anandasabapathy.
Gastrointest Endosc, 2020 Jul 20; 93(4). PMID: 32682812    Free PMC article.
Optimization of an automated tumor-infiltrating lymphocyte algorithm for improved prognostication in primary melanoma.
Margaret Chou, Irineu Illa-Bochaca, +8 authors, Hua Zhong.
Mod Pathol, 2020 Oct 03; 34(3). PMID: 33005020    Free PMC article.
Deep learning powers cancer diagnosis in digital pathology.
Yunjie He, Hong Zhao, Stephen T C Wong.
Comput Med Imaging Graph, 2021 Jan 17; 88. PMID: 33453648    Free PMC article.
Review.
Clinician checklist for assessing suitability of machine learning applications in healthcare.
Ian Scott, Stacey Carter, Enrico Coiera.
BMJ Health Care Inform, 2021 Feb 07; 28(1). PMID: 33547086    Free PMC article.
Boosted EfficientNet: Detection of Lymph Node Metastases in Breast Cancer Using Convolutional Neural Networks.
Jun Wang, Qianying Liu, +2 authors, Hefeng Zhou.
Cancers (Basel), 2021 Feb 11; 13(4). PMID: 33562232    Free PMC article.
Artificial intelligence assistance significantly improves Gleason grading of prostate biopsies by pathologists.
Wouter Bulten, Maschenka Balkenhol, +20 authors, Geert Litjens.
Mod Pathol, 2020 Aug 08; 34(3). PMID: 32759979    Free PMC article.
Deep learning for biomedical photoacoustic imaging: A review.
Janek Gröhl, Melanie Schellenberg, Kris Dreher, Lena Maier-Hein.
Photoacoustics, 2021 Mar 16; 22. PMID: 33717977    Free PMC article.
Review.
Artificial intelligence (AI) in medicine, current applications and future role with special emphasis on its potential and promise in pathology: present and future impact, obstacles including costs and acceptance among pathologists, practical and philosophical considerations. A comprehensive review.
Zubair Ahmad, Shabina Rahim, Maha Zubair, Jamshid Abdul-Ghafar.
Diagn Pathol, 2021 Mar 19; 16(1). PMID: 33731170    Free PMC article.
Review.
Association of Clinician Diagnostic Performance With Machine Learning-Based Decision Support Systems: A Systematic Review.
Baptiste Vasey, Stephan Ursprung, +5 authors, Peter McCulloch.
JAMA Netw Open, 2021 Mar 12; 4(3). PMID: 33704476    Free PMC article.
Systematic Review.
Predicting gastric cancer outcome from resected lymph node histopathology images using deep learning.
Xiaodong Wang, Ying Chen, +15 authors, Guanzhen Yu.
Nat Commun, 2021 Mar 14; 12(1). PMID: 33712598    Free PMC article.
Deep learning for computer-assisted diagnosis of hereditary diffuse gastric cancer.
Sean A Rasmussen, Thomas Arnason, Weei-Yuarn Huang.
J Pathol Transl Med, 2021 Jan 22; 55(2). PMID: 33472333    Free PMC article.
The Potential of Artificial Intelligence to Detect Lymphovascular Invasion in Testicular Cancer.
Abhisek Ghosh, Korsuk Sirinukunwattana, +8 authors, Clare Verrill.
Cancers (Basel), 2021 Apr 04; 13(6). PMID: 33809521    Free PMC article.
Detecting Digoxin Toxicity by Artificial Intelligence-Assisted Electrocardiography.
Da-Wei Chang, Chin-Sheng Lin, +5 authors, Chin Lin.
Int J Environ Res Public Health, 2021 May 01; 18(7). PMID: 33917563    Free PMC article.
Artificial Intelligence & Tissue Biomarkers: Advantages, Risks and Perspectives for Pathology.
Cesare Lancellotti, Pierandrea Cancian, +4 authors, Luca Di Tommaso.
Cells, 2021 May 01; 10(4). PMID: 33918173    Free PMC article.
Review.
Validation of a DKK1 RNAscope chromogenic in situ hybridization assay for gastric and gastroesophageal junction adenocarcinoma tumors.
Charles Caldwell, James B Rottman, +10 authors, Michael H Kagey.
Sci Rep, 2021 May 12; 11(1). PMID: 33972574    Free PMC article.
Role of Artificial Intelligence Applications in Real-Life Clinical Practice: Systematic Review.
Jiamin Yin, Kee Yuan Ngiam, Hock Hai Teo.
J Med Internet Res, 2021 Apr 23; 23(4). PMID: 33885365    Free PMC article.
Systematic Review.
Computer Vision for Brain Disorders Based Primarily on Ocular Responses.
Xiaotao Li, Fangfang Fan, +9 authors, Kwok-Fai So.
Front Neurol, 2021 May 11; 12. PMID: 33967931    Free PMC article.
Evaluation of the Use of Single- and Multi-Magnification Convolutional Neural Networks for the Determination and Quantitation of Lesions in Nonclinical Pathology Studies.
Jogile Kuklyte, Jenny Fitzgerald, +14 authors, Donal O'Shea.
Toxicol Pathol, 2021 Feb 24; 49(4). PMID: 33618634    Free PMC article.
Artificial intelligence (AI) in medicine as a strategic valuable tool.
Andreas Larentzakis, Nik Lygeros.
Pan Afr Med J, 2021 May 18; 38. PMID: 33995790    Free PMC article.
AI applications in renal pathology.
Yuankai Huo, Ruining Deng, +2 authors, Haichun Yang.
Kidney Int, 2021 Feb 14; 99(6). PMID: 33581198    Free PMC article.
Review.
Deep Learning for the Classification of Non-Hodgkin Lymphoma on Histopathological Images.
Georg Steinbuss, Mark Kriegsmann, +5 authors, Katharina Kriegsmann.
Cancers (Basel), 2021 Jun 03; 13(10). PMID: 34067726    Free PMC article.
Classification of Diffuse Glioma Subtype from Clinical-Grade Pathological Images Using Deep Transfer Learning.
Sanghyuk Im, Jonghwan Hyeon, +4 authors, Tae-Jung Kim.
Sensors (Basel), 2021 Jun 03; 21(10). PMID: 34067934    Free PMC article.
Requirements for implementation of artificial intelligence in the practice of gastrointestinal pathology.
Hiroshi Yoshida, Tomoharu Kiyuna.
World J Gastroenterol, 2021 Jun 18; 27(21). PMID: 34135556    Free PMC article.
Review.
Artificial intelligence in oncology: Path to implementation.
Isaac S Chua, Michal Gaziel-Yablowitz, +6 authors, Michael Hassett.
Cancer Med, 2021 May 08; 10(12). PMID: 33960708    Free PMC article.
Review.
Welcoming new guidelines for AI clinical research.
Eric J Topol.
Nat Med, 2020 Sep 11; 26(9). PMID: 32908274
Articles That Use Artificial Intelligence for Ultrasound: A Reader's Guide.
Ming Kuang, Hang-Tong Hu, +2 authors, Xiao-Zhou Lu.
Front Oncol, 2021 Jun 29; 11. PMID: 34178622    Free PMC article.
Review.
Dissecting the Business Case for Adoption and Implementation of Digital Pathology: A White Paper from the Digital Pathology Association.
Giovanni Lujan, Jennifer C Quigley, +16 authors, Doug Bowman.
J Pathol Inform, 2021 Jul 06; 12. PMID: 34221633    Free PMC article.
Using Artificial Intelligence to Detect, Classify, and Objectively Score Severity of Rodent Cardiomyopathy.
Debra A Tokarz, Thomas J Steinbach, +10 authors, Torrie A Crabbs.
Toxicol Pathol, 2020 Dec 09; 49(4). PMID: 33287662    Free PMC article.
Machine learning-based image analysis for accelerating the diagnosis of complicated preneoplastic and neoplastic ductal lesions in breast biopsy tissues.
Shinya Sato, Satoshi Maki, +11 authors, Yohei Miyagi.
Breast Cancer Res Treat, 2021 May 03; 188(3). PMID: 33934277
Artificial Intelligence in Pathology.
Sebastian Försch, Frederick Klauschen, Peter Hufnagl, Wilfried Roth.
Dtsch Arztebl Int, 2021 May 25; 118(12). PMID: 34024323    Free PMC article.
Review.
Prediction of patient disposition: comparison of computer and human approaches and a proposed synthesis.
Yuval Barak-Corren, Isha Agarwal, +10 authors, Andrew M Fine.
J Am Med Inform Assoc, 2021 May 20; 28(8). PMID: 34010406    Free PMC article.
Deep Learning Fast Screening Approach on Cytological Whole Slides for Thyroid Cancer Diagnosis.
Yi-Jia Lin, Tai-Kuang Chao, +4 authors, Ching-Wei Wang.
Cancers (Basel), 2021 Aug 08; 13(15). PMID: 34359792    Free PMC article.
Randomized multi-reader evaluation of automated detection and segmentation of brain tumors in stereotactic radiosurgery with deep neural networks.
Shao-Lun Lu, Fu-Ren Xiao, +8 authors, Feng-Ming Hsu.
Neuro Oncol, 2021 Mar 24; 23(9). PMID: 33754155    Free PMC article.
Deeply Supervised UNet for Semantic Segmentation to Assist Dermatopathological Assessment of Basal Cell Carcinoma.
Jean Le'Clerc Arrastia, Nick Heilenkötter, +6 authors, Peter Maass.
J Imaging, 2021 Aug 31; 7(4). PMID: 34460521    Free PMC article.
Evaluation of machine learning solutions in medicine.
Tony Antoniou, Muhammad Mamdani.
CMAJ, 2021 Sep 01; 193(36). PMID: 34462315    Free PMC article.
WaveSleepNet: An interpretable deep convolutional neural network for the continuous classification of mouse sleep and wake.
Korey Kam, David M Rapoport, +2 authors, Andrew W Varga.
J Neurosci Methods, 2021 May 31; 360. PMID: 34052291    Free PMC article.
Identification of nodal micrometastasis in colorectal cancer using deep learning on annotation-free whole-slide images.
Wen-Yu Chuang, Chi-Chung Chen, +7 authors, Chao-Yuan Yeh.
Mod Pathol, 2021 Jun 10; 34(10). PMID: 34103664    Free PMC article.