Journal Article
. 2018 Oct; 379(20):1926-1936.
doi: 10.1056/NEJMoa1810527.

Overall Survival with Palbociclib and Fulvestrant in Advanced Breast Cancer

Nicholas C Turner 1 Dennis J Slamon 1 Jungsil Ro 1 Igor Bondarenko 1 Seock-Ah Im 1 Norikazu Masuda 1 Marco Colleoni 1 Angela DeMichele 1 Sherene Loi 1 Sunil Verma 1 Hiroji Iwata 1 Nadia Harbeck 1 Sibylle Loibl 1 Fabrice André 1 Kathy Puyana Theall 1 Xin Huang 1 Carla Giorgetti 1 Cynthia Huang Bartlett 1 Massimo Cristofanilli 1 
  • PMID: 30345905
  •     180 citations


Background: The cyclin-dependent kinase 4 and 6 (CDK4/6) inhibitor palbociclib, in combination with fulvestrant therapy, prolongs progression-free survival among patients with hormone-receptor-positive, human epidermal growth factor receptor 2 (HER2)-negative advanced breast cancer. We report the results of a prespecified analysis of overall survival.

Methods: We randomly assigned patients with hormone-receptor-positive, HER2-negative advanced breast cancer who had progression or relapse during previous endocrine therapy to receive palbociclib plus fulvestrant or placebo plus fulvestrant. We analyzed overall survival; the effect of palbociclib according to the prespecified stratification factors of presence or absence of sensitivity to endocrine therapy, presence or absence of visceral metastatic disease, and menopausal status; the efficacy of subsequent therapies after disease progression; and safety.

Results: Among 521 patients who underwent randomization, the median overall survival was 34.9 months (95% confidence interval [CI], 28.8 to 40.0) in the palbociclib-fulvestrant group and 28.0 months (95% CI, 23.6 to 34.6) in the placebo-fulvestrant group (hazard ratio for death, 0.81; 95% CI, 0.64 to 1.03; P=0.09; absolute difference, 6.9 months). CDK4/6 inhibitor treatment after the completion of the trial regimen occurred in 16% of the patients in the placebo-fulvestrant group. Among 410 patients with sensitivity to previous endocrine therapy, the median overall survival was 39.7 months (95% CI, 34.8 to 45.7) in the palbociclib-fulvestrant group and 29.7 months (95% CI, 23.8 to 37.9) in the placebo-fulvestrant group (hazard ratio, 0.72; 95% CI, 0.55 to 0.94; absolute difference, 10.0 months). The median duration of subsequent therapy was similar in the two groups, and the median time to the receipt of chemotherapy was 17.6 months in the palbociclib-fulvestrant group, as compared with 8.8 months in the placebo-fulvestrant group (hazard ratio, 0.58; 95% CI, 0.47 to 0.73; P<0.001). No new safety signals were observed with 44.8 months of follow-up.

Conclusions: Among patients with hormone-receptor-positive, HER2-negative advanced breast cancer who had sensitivity to previous endocrine therapy, treatment with palbociclib-fulvestrant resulted in longer overall survival than treatment with placebo-fulvestrant. The differences in overall survival in the entire trial group were not significant. (Funded by Pfizer; PALOMA-3 number, NCT01942135 .).

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Pharmacokinetic and Pharmacodynamic Studies of Elacestrant, A Novel Oral Selective Estrogen Receptor Degrader, in Healthy Post-Menopausal Women.
Maureen G Conlan, Erik F J de Vries, +2 authors, Steven Troy.
Eur J Drug Metab Pharmacokinet, 2020 Jul 15; 45(5). PMID: 32661909    Free PMC article.
Caring for the caregiver: a systematic review characterising the experience of caregivers of older adults with advanced cancers.
Jacob J Adashek, Ishwaria M Subbiah.
ESMO Open, 2020 Sep 24; 5(5). PMID: 32963088    Free PMC article.
Molecular alterations and targeted therapy in pancreatic ductal adenocarcinoma.
Yunzhen Qian, Yitao Gong, +8 authors, Chen Liu.
J Hematol Oncol, 2020 Oct 04; 13(1). PMID: 33008426    Free PMC article.
Treatment effect of palbociclib plus endocrine therapy by prognostic and intrinsic subtype and biomarker analysis in patients with bone-only disease: a joint analysis of PALOMA-2 and PALOMA-3 clinical trials.
Richard S Finn, Massimo Cristofanilli, +11 authors, Hope S Rugo.
Breast Cancer Res Treat, 2020 Aug 13; 184(1). PMID: 32783178    Free PMC article.
Targeting Cell Cycle in Breast Cancer: CDK4/6 Inhibitors.
Michela Piezzo, Stefania Cocco, +8 authors, Michelino De Laurentiis.
Int J Mol Sci, 2020 Sep 10; 21(18). PMID: 32899866    Free PMC article.
Integrating Old and New Paradigms of G1/S Control.
Seth M Rubin, Julien Sage, Jan M Skotheim.
Mol Cell, 2020 Sep 19; 80(2). PMID: 32946743    Free PMC article.
CDK4/6 Inhibitors in Hormone Receptor-Positive Metastatic Breast Cancer: Current Practice and Knowledge.
Debora de Melo Gagliato, Antonio C Buzaid, +2 authors, Javier Cortes.
Cancers (Basel), 2020 Sep 05; 12(9). PMID: 32882980    Free PMC article.
Building towards Precision Oncology for Pancreatic Cancer: Real-World Challenges and Opportunities.
Yifan Wang, Anna Lakoma, George Zogopoulos.
Genes (Basel), 2020 Sep 25; 11(9). PMID: 32967105    Free PMC article.
Safety and efficacy of cyclin-dependent kinase inhibitor rechallenge following ribociclib-induced limiting hypertransaminasemia.
Jesús Fuentes-Antrás, Alicia de Luna, +3 authors, Fernando Moreno.
Breast, 2020 Oct 24; 54. PMID: 33096323    Free PMC article.
Endocrine therapy combined with targeted therapy in hormone receptor-positive metastatic breast cancer.
Li Bian, Feng-Rui Xu, Ze-Fei Jiang.
Chin Med J (Engl), 2020 Aug 28; 133(19). PMID: 32852380    Free PMC article.
Eligibility of real-world patients with metastatic breast cancer for clinical trials.
Atul Batra, Shiying Kong, Winson Y Cheung.
Breast, 2020 Oct 30; 54. PMID: 33120082    Free PMC article.
Comparison of Endocrine Therapies in Hormone Receptor-Positive and Human Epidermal Growth Factor Receptor 2-Negative Locally Advanced or Metastatic Breast Cancer: A Network Meta-Analysis.
Siqi Liu, Xin Sun, Xiaohui Xu, Fangcai Lin.
J Breast Cancer, 2020 Nov 07; 23(5). PMID: 33154823    Free PMC article.
Update Breast Cancer 2020 Part 4 - Advanced Breast Cancer.
Hans Tesch, Volkmar Müller, +16 authors, Wolfgang Janni.
Geburtshilfe Frauenheilkd, 2020 Nov 12; 80(11). PMID: 33173239    Free PMC article.
Comparative Overall Survival of CDK4/6 Inhibitors Plus Endocrine Therapy vs. Endocrine Therapy Alone for Hormone receptor-positive, HER2-negative metastatic breast cancer.
Mingxi Lin, Yang Chen, +2 authors, Jian Zhang.
J Cancer, 2020 Nov 17; 11(24). PMID: 33193875    Free PMC article.
Resistance and Overcoming Resistance in Breast Cancer.
Andrea Luque-Bolivar, Erika Pérez-Mora, Victoria Eugenia Villegas, Milena Rondón-Lagos.
Breast Cancer (Dove Med Press), 2020 Nov 19; 12. PMID: 33204149    Free PMC article.
Exploring treatment with Ribociclib alone or in sequence/combination with Everolimus in ER+HER2-Rb wild-type and knock-down in breast cancer cell lines.
Oliviero Marinelli, Emanuela Romagnoli, +6 authors, Giorgio Santoni.
BMC Cancer, 2020 Nov 21; 20(1). PMID: 33213401    Free PMC article.
Overall Survival of CDK4/6-Inhibitor-Based Treatments in Clinically Relevant Subgroups of Metastatic Breast Cancer: Systematic Review and Meta-Analysis.
Francesco Schettini, Fabiola Giudici, +17 authors, Daniele Generali.
J Natl Cancer Inst, 2020 May 15; 112(11). PMID: 32407488    Free PMC article.
Systematic Review.
Hyperactive CDK2 Activity in Basal-like Breast Cancer Imposes a Genome Integrity Liability that Can Be Exploited by Targeting DNA Polymerase ε.
Vladislav O Sviderskiy, Lili Blumenberg, +14 authors, Richard Possemato.
Mol Cell, 2020 Nov 06; 80(4). PMID: 33152268    Free PMC article.
CDK4/6 inhibition in HR-positive early breast cancer: are we putting all eggs in one basket?
Elisa Agostinetto, Rafael Caparica, Evandro de Azambuja.
ESMO Open, 2020 Nov 19; 5(6). PMID: 33203686    Free PMC article.
Major clinical research advances in gynecologic cancer in 2018.
Miseon Kim, Dong Hoon Suh, +4 authors, Jae Weon Kim.
J Gynecol Oncol, 2019 Feb 26; 30(2). PMID: 30806045    Free PMC article.
Update Breast Cancer 2019 Part 2 - Implementation of Novel Diagnostics and Therapeutics in Advanced Breast Cancer Patients in Clinical Practice.
Wolfgang Janni, Andreas Schneeweiss, +14 authors, Johannes Ettl.
Geburtshilfe Frauenheilkd, 2019 Mar 19; 79(3). PMID: 30880825    Free PMC article.
Development and validation of a nomogram in survival prediction among advanced breast cancer patients.
Jianli Zhao, Yaping Yang, +15 authors, Ying Wang.
Ann Transl Med, 2020 Dec 15; 8(21). PMID: 33313191    Free PMC article.
CDK 4/6 inhibitors combined with radiotherapy: A review of literature.
Claire Bosacki, Wafa Bouleftour, +7 authors, Nicolas Magné.
Clin Transl Radiat Oncol, 2020 Dec 16; 26. PMID: 33319074    Free PMC article.
Therapeutic Perspectives on the Modulation of G-Protein Coupled Estrogen Receptor, GPER, Function.
Milad Rouhimoghadam, Anh S Lu, Aliasger K Salem, Edward J Filardo.
Front Endocrinol (Lausanne), 2020 Dec 18; 11. PMID: 33329395    Free PMC article.
Short-term CDK4/6 Inhibition Radiosensitizes Estrogen Receptor-Positive Breast Cancers.
Andrea M Pesch, Nicole H Hirsh, +10 authors, Corey W Speers.
Clin Cancer Res, 2020 Sep 25; 26(24). PMID: 32967938    Free PMC article.
Long-term impact of bone-modifying agents for the treatment of bone metastases: a systematic review.
Terry L Ng, Megan M Tu, +12 authors, Mark J Clemons.
Support Care Cancer, 2020 Jun 15; 29(2). PMID: 32535678
Systematic Review.
Inhibiting CDK4/6 in Breast Cancer with Palbociclib, Ribociclib, and Abemaciclib: Similarities and Differences.
C Louwrens Braal, Elisabeth M Jongbloed, +3 authors, Agnes Jager.
Drugs, 2020 Dec 29; 81(3). PMID: 33369721    Free PMC article.
CDK 4/6 inhibitors mired in uncertainty in HR positive and HER2 negative early breast cancer.
Serena Di Cosimo, Luca Porcu, Fatima Cardoso.
Breast, 2020 Dec 23; 55. PMID: 33352521    Free PMC article.
RON signalling promotes therapeutic resistance in ESR1 mutant breast cancer.
Derek Dustin, Guowei Gu, +14 authors, Suzanne A W Fuqua.
Br J Cancer, 2020 Dec 02; 124(1). PMID: 33257837    Free PMC article.
Invasive lobular carcinoma of the breast: the increasing importance of this special subtype.
Amy E McCart Reed, Lauren Kalinowski, Peter T Simpson, Sunil R Lakhani.
Breast Cancer Res, 2021 Jan 09; 23(1). PMID: 33413533    Free PMC article.
The immunomodulatory effects of endocrine therapy in breast cancer.
Huanhuan Huang, Jun Zhou, +4 authors, Chao Ni.
J Exp Clin Cancer Res, 2021 Jan 09; 40(1). PMID: 33413549    Free PMC article.
Enhanced toxicity with CDK 4/6 inhibitors and palliative radiotherapy: Non-consecutive case series and review of the literature.
Steven David, Gwo Ho, +8 authors, Michelle White.
Transl Oncol, 2020 Nov 24; 14(1). PMID: 33227663    Free PMC article.
Palbociclib combined with endocrine therapy in heavily pretreated HR+/HER2- advanced breast cancer patients: Results from the compassionate use program in Spain (PALBOCOMP).
Luis Manso, Cristina Hernando, +32 authors, Fernando Moreno.
Breast, 2020 Nov 27; 54. PMID: 33242755    Free PMC article.
Real life efficacy of palbociclib and endocrine therapy in HR positive, HER2 negative advanced breast cancer.
B Porte, M Carton, +7 authors, P Cottu.
Breast, 2020 Nov 27; 54. PMID: 33242757    Free PMC article.
Significance of the Genomic Landscape of a De Novo Endocrine-Resistant Metastatic Hormone Receptor-Positive Breast Cancer.
Maithreyi Sarma, Yara Abdou, Ajay Dhakal, Shipra Gandhi.
Breast Cancer (Auckl), 2021 Jan 07; 14. PMID: 33402826    Free PMC article.
Real-World Outcomes of Treating Advanced Breast Cancer Patients With Palbociclib: A Multicenter Retrospective Cohort Study in Japan-The KBCOG-14 Study.
Nina Odan, Yuichiro Kikawa, +8 authors, Shintaro Takao.
Breast Cancer (Auckl), 2021 Jan 16; 14. PMID: 33447040    Free PMC article.
Therapy Algorithms for the Diagnosis and Treatment of Patients with Early and Advanced Breast Cancer.
Andreas Schneeweiss, Ingo Bauerfeind, +5 authors, Volkmar Müller.
Breast Care (Basel), 2021 Jan 16; 15(6). PMID: 33447235    Free PMC article.
The androgen receptor is a tumor suppressor in estrogen receptor-positive breast cancer.
Theresa E Hickey, Luke A Selth, +21 authors, Wayne D Tilley.
Nat Med, 2021 Jan 20; 27(2). PMID: 33462444
Targeting G1/S phase cell-cycle genomic alterations and accompanying co-alterations with individualized CDK4/6 inhibitor-based regimens.
Shumei Kato, Ryosuke Okamura, +5 authors, Razelle Kurzrock.
JCI Insight, 2021 Jan 12; 6(1). PMID: 33427211    Free PMC article.
CDK4/6 Inhibitor Treatments in Patients with Hormone Receptor Positive, Her2 Negative Advanced Breast Cancer: Potential Molecular Mechanisms, Clinical Implications and Future Perspectives.
Michela Roberto, Antonio Astone, +19 authors, Paolo Marchetti.
Cancers (Basel), 2021 Jan 23; 13(2). PMID: 33477469    Free PMC article.
Clinical Challenges in the Management of Hormone Receptor-Positive, Human Epidermal Growth Factor Receptor 2-Negative Metastatic Breast Cancer: A Literature Review.
Gayathri Nagaraj, Cynthia X Ma.
Adv Ther, 2020 Nov 16; 38(1). PMID: 33190190    Free PMC article.
Steroid Hormone Receptor and Infiltrating Immune Cell Status Reveals Therapeutic Vulnerabilities of ESR1-Mutant Breast Cancer.
Michelle M Williams, Nicole S Spoelstra, +15 authors, Jennifer K Richer.
Cancer Res, 2020 Nov 14; 81(3). PMID: 33184106    Free PMC article.
ESR1 NAPA Assay: Development and Analytical Validation of a Highly Sensitive and Specific Blood-Based Assay for the Detection of ESR1 Mutations in Liquid Biopsies.
Dimitra Stergiopoulou, Athina Markou, +4 authors, Evi Lianidou.
Cancers (Basel), 2021 Feb 05; 13(3). PMID: 33535614    Free PMC article.
Optimizing Palbociclib Therapy Across the Age Spectrum: Hypothetical, Illustrative Case Scenarios in HR+, HER2-Metastatic Breast Cancer.
Kimberly Podsada, Joanne C Ryan, Kristi Orbaugh.
J Adv Pract Oncol, 2021 Feb 13; 11(7). PMID: 33575067    Free PMC article.
FGFR1 amplification or overexpression and hormonal resistance in luminal breast cancer: rationale for a triple blockade of ER, CDK4/6, and FGFR1.
Silvana Mouron, Luis Manso, +6 authors, Maria J Bueno.
Breast Cancer Res, 2021 Feb 14; 23(1). PMID: 33579347    Free PMC article.
Everolimus Plus Exemestane Treatment in Patients with Metastatic Hormone Receptor-Positive Breast Cancer Previously Treated with CDK4/6 Inhibitor Therapy.
Madeline M Cook, Luai Al Rabadi, +3 authors, Zahi I Mitri.
Oncologist, 2020 Nov 25; 26(2). PMID: 33230905    Free PMC article.
CDK6 Is a Potential Prognostic Biomarker in Acute Myeloid Leukemia.
Wei Liu, Jin-Mou Yi, +8 authors, Hui Zeng.
Front Genet, 2021 Feb 19; 11. PMID: 33597968    Free PMC article.
An evaluation of palbociclib as a breast cancer treatment option: a current update.
Gregory T Gallanis, Ramon I Pericas, Anna T Riegel, Paula R Pohlmann.
Expert Opin Pharmacother, 2020 Nov 18; 22(3). PMID: 33198527    Free PMC article.
Distinct mechanisms of resistance to fulvestrant treatment dictate level of ER independence and selective response to CDK inhibitors in metastatic breast cancer.
Kamila Kaminska, Nina Akrap, +14 authors, Gabriella Honeth.
Breast Cancer Res, 2021 Feb 20; 23(1). PMID: 33602273    Free PMC article.
Meta-analyses of visceral versus non-visceral metastatic hormone receptor-positive breast cancer treated by endocrine monotherapies.
John F R Robertson, Angelo Di Leo, +6 authors, Christine Campbell.
NPJ Breast Cancer, 2021 Feb 14; 7(1). PMID: 33579962    Free PMC article.
Case Report: Significant Response to Immune Checkpoint Inhibitor Camrelizumab in a Heavily Pretreated Advanced ER+/HER2- Breast Cancer Patient With High Tumor Mutational Burden.
Rong Wang, Yuchen Yang, +6 authors, Wen-Ming Cao.
Front Oncol, 2021 Feb 27; 10. PMID: 33634015    Free PMC article.
Palbociclib Plus Fulvestrant in Korean Patients from PALOMA-3 With Hormone Receptor-Positive/Human Epidermal Growth Factor Receptor 2-Negative Advanced Breast Cancer.
Jee Hyun Kim, Seock Ah Im, +4 authors, Sung Bae Kim.
J Breast Cancer, 2021 Feb 27; 24(1). PMID: 33634624    Free PMC article.
Impact of treatment schedule on the efficacy of cytostatic and immunostimulatory agents.
Giulia Petroni, Lorenzo Galluzzi.
Oncoimmunology, 2021 Mar 05; 10(1). PMID: 33659100    Free PMC article.
Clinical Perspectives in Addressing Unsolved Issues in (Neo)Adjuvant Therapy for Primary Breast Cancer.
Ryungsa Kim, Takanori Kin.
Cancers (Basel), 2021 Mar 07; 13(4). PMID: 33672204    Free PMC article.
Validation and comparison of Breast Graded Prognostic Assessment scores in patients with breast cancer and brain metastases.
C Fabregat-Franco, A Stradella, +13 authors, M J Gil-Gil.
Clin Transl Oncol, 2021 Mar 12;. PMID: 33704689
Safety and efficacy of everolimus (EVE) plus exemestane (EXE) in postmenopausal women with locally advanced or metastatic breast cancer: final results from EVEREXES.
Young-Hyuck Im, Bulent Karabulut, +13 authors, Sung-Bae Kim.
Breast Cancer Res Treat, 2021 Mar 18;. PMID: 33728524
Analysis of subsequent therapy in Japanese patients with hormone receptor‒positive/human epidermal growth factor receptor 2‒negative advanced breast cancer who received palbociclib plus endocrine therapy in PALOMA-2 and -3.
Norikazu Masuda, Hirofumi Mukai, +9 authors, Masakazu Toi.
Breast Cancer, 2020 Oct 22; 28(2). PMID: 33085032    Free PMC article.
Comparative effectiveness of first-line palbociclib plus letrozole versus letrozole alone for HR+/HER2- metastatic breast cancer in US real-world clinical practice.
Angela DeMichele, Massimo Cristofanilli, +8 authors, Richard S Finn.
Breast Cancer Res, 2021 Mar 26; 23(1). PMID: 33761995    Free PMC article.
Patterns of treatment and outcome of palbociclib plus endocrine therapy in hormone receptor-positive/HER2 receptor-negative metastatic breast cancer: a real-world multicentre Italian study.
Raffaella Palumbo, Rosalba Torrisi, +11 authors, Erica Quaquarini.
Ther Adv Med Oncol, 2021 Apr 03; 13. PMID: 33796150    Free PMC article.
Endocrine-Based Treatments in Clinically-Relevant Subgroups of Hormone Receptor-Positive/HER2-Negative Metastatic Breast Cancer: Systematic Review and Meta-Analysis.
Francesco Schettini, Mario Giuliano, +18 authors, Daniele Generali.
Cancers (Basel), 2021 Apr 04; 13(6). PMID: 33810205    Free PMC article.
HMGB1 is a key factor for tamoxifen resistance and has the potential to predict the efficacy of CDK4/6 inhibitors in breast cancer.
Han Zhang, Jinlu Wang, +8 authors, Qingyuan Zhang.
Cancer Sci, 2021 Jan 17; 112(4). PMID: 33453094    Free PMC article.
Reporting of harms in oncological clinical study reports submitted to the European Medicines Agency compared to trial registries and publications-a methodological review.
Asger S Paludan-Müller, Perrine Créquit, Isabelle Boutron.
BMC Med, 2021 Apr 09; 19(1). PMID: 33827569    Free PMC article.
A phase 1 study of dalpiciclib, a cyclin-dependent kinase 4/6 inhibitor in Chinese patients with advanced breast cancer.
Pin Zhang, Binghe Xu, +6 authors, Jianjun Zou.
Biomark Res, 2021 Apr 14; 9(1). PMID: 33845905    Free PMC article.
Arctigenin inhibits human breast cancer cell proliferation, migratory and invasive abilities and epithelial to mesenchymal transition by targeting 4EBP1.
Wenfang Luo, Fei Wang, Hewei Luo, Hui Liu.
Exp Ther Med, 2021 Apr 15; 21(6). PMID: 33850519    Free PMC article.
Clinical outcomes of platinum-based chemotherapy in patients with advanced breast cancer: An 11-year single institutional experience.
Maria Alice Franzoi, Rita Saúde-Conde, +3 authors, Evandro de Azambuja.
Breast, 2021 Apr 03; 57. PMID: 33799232    Free PMC article.
First- and second-line treatment strategies for hormone-receptor (HR)-positive HER2-negative metastatic breast cancer: A real-world study.
Debora Basile, Lorenzo Gerratana, +15 authors, Fabio Puglisi.
Breast, 2021 Apr 04; 57. PMID: 33812267    Free PMC article.
Recurrent urothelial carcinoma-like FGFR3 genomic alterations in malignant Brenner tumors of the ovary.
Douglas I Lin, Jonathan K Killian, +3 authors, Julia A Elvin.
Mod Pathol, 2020 Oct 21; 34(5). PMID: 33077920
Assessment of Resistance Mechanisms and Clinical Implications in Patients with KRAS Mutated-Metastatic Breast Cancer and Resistance to CDK4/6 Inhibitors.
Lucrezia Raimondi, Filippo Maria Raimondi, +6 authors, Gian Paolo Spinelli.
Cancers (Basel), 2021 May 01; 13(8). PMID: 33923563    Free PMC article.
CDK 4/6 inhibitors are associated with a high incidence of thrombotic events in women with breast cancer in real-world practice.
Malinda T West, Claire E Smith, +7 authors, Joseph J Shatzel.
Eur J Haematol, 2021 Feb 03; 106(5). PMID: 33527479    Free PMC article.
Association of Cyclin-Dependent Kinases 4 and 6 Inhibitors With Survival in Patients With Hormone Receptor-Positive Metastatic Breast Cancer: A Systematic Review and Meta-analysis.
Jinming Li, Xingfa Huo, +5 authors, Jiuda Zhao.
JAMA Netw Open, 2020 Oct 14; 3(10). PMID: 33048129    Free PMC article.
Systematic Review.
Selective AKT kinase inhibitor capivasertib in combination with fulvestrant in PTEN-mutant ER-positive metastatic breast cancer.
Lillian M Smyth, Gerald Batist, +24 authors, Sarat Chandarlapaty.
NPJ Breast Cancer, 2021 Apr 18; 7(1). PMID: 33863913    Free PMC article.
Cost-effectiveness of ribociclib plus letrozole versus palbociclib plus letrozole or letrozole as monotherapy in first-line treatment of postmenopausal women with HR+/HER2- locally advanced or metastatic breast cancer: a Brazilian private payer perspective.
Anna Maria Buehler, Gabriela Castilho, Pierre-Alexandre Dionne, Stephen Stefani.
Ther Adv Med Oncol, 2021 May 06; 13. PMID: 33948121    Free PMC article.
Emerging Skin Toxicities in Patients with Breast Cancer Treated with New Cyclin-Dependent Kinase 4/6 Inhibitors: A Systematic Review.
Martina Silvestri, Antonio Cristaudo, +5 authors, Norma Cameli.
Drug Saf, 2021 May 08;. PMID: 33959899
Evidence-based statistical analysis and methods in biomedical research (SAMBR) checklists according to design features.
Alok Kumar Dwivedi, Rakesh Shukla.
Cancer Rep (Hoboken), 2020 Aug 15; 3(4). PMID: 32794640    Free PMC article.
Long-Term Pooled Safety Analysis of Palbociclib in Combination with Endocrine Therapy for Hormone Receptor-Positive/Human Epidermal Growth Factor Receptor 2-Negative Advanced Breast Cancer: Updated Analysis with up to 5 Years of Follow-Up.
Richard S Finn, Hope S Rugo, +11 authors, Véronique Diéras.
Oncologist, 2021 Jan 25; 26(5). PMID: 33486783    Free PMC article.
Phase II Trial of Palbociclib in Patients with Advanced Esophageal or Gastric Cancer.
Thomas Benjamin Karasic, Mark H O'Hara, +6 authors, Peter J O'Dwyer.
Oncologist, 2020 Jul 22; 25(12). PMID: 32692450    Free PMC article.
Lasofoxifene as a potential treatment for therapy-resistant ER-positive metastatic breast cancer.
Muriel Lainé, Sean W Fanning, +6 authors, Geoffrey L Greene.
Breast Cancer Res, 2021 May 14; 23(1). PMID: 33980285    Free PMC article.
Evolution of overall survival and receipt of new therapies by subtype among 20 446 metastatic breast cancer patients in the 2008-2017 ESME cohort.
T Grinda, A Antoine, +24 authors, S Delaloge.
ESMO Open, 2021 Apr 26; 6(3). PMID: 33895695    Free PMC article.
Breast Cancer Therapeutics and Biomarkers: Past, Present, and Future Approaches.
Jason Schick, Raquel P Ritchie, Carolina Restini.
Breast Cancer (Auckl), 2021 May 18; 15. PMID: 33994789    Free PMC article.
Global Trend in Research and Development of CDK4/6 Inhibitors for Clinical Cancer Therapy: A Bibliometric Analysis.
Hongna Lai, Wei Jiang, +5 authors, Herui Yao.
J Cancer, 2021 May 18; 12(12). PMID: 33995631    Free PMC article.
First Experiences with Alpelisib in Clinical Routine: Case Reports from a German Breast Center.
Anna Hester, Franziska Henze, +2 authors, Rachel Wuerstlein.
Breast Care (Basel), 2021 May 21; 16(2). PMID: 34012367    Free PMC article.
Treatment of Luminal Metastatic Breast Cancer beyond CDK4/6 Inhibition: Is There a Standard of Care in Clinical Practice?
Athanasios Mavratzas, Frederik Marmé.
Breast Care (Basel), 2021 May 21; 16(2). PMID: 34012366    Free PMC article.
Cost-Effectiveness of Adding Ribociclib to Endocrine Therapy for Patients With HR-Positive, HER2-Negative Advanced Breast Cancer Among Premenopausal or Perimenopausal Women.
Eunae Jeong, Changjun Wang, Leslie Wilson, Lixian Zhong.
Front Oncol, 2021 May 25; 11. PMID: 34026637    Free PMC article.
The breast is yet to come: current and future utility of circulating tumour DNA in breast cancer.
Brad A Davidson, Sarah Croessmann, Ben H Park.
Br J Cancer, 2021 May 28;. PMID: 34040179
CATCH: A Prospective Precision Oncology Trial in Metastatic Breast Cancer.
Mario Hlevnjak, Markus Schulze, +28 authors, Andreas Schneeweiss.
JCO Precis Oncol, 2021 May 27; 5. PMID: 34036222    Free PMC article.
Current Landscape of Targeted Therapy in Hormone Receptor-Positive and HER2-Negative Breast Cancer.
Samitha Andrahennadi, Amer Sami, +2 authors, Shahid Ahmed.
Curr Oncol, 2021 Jun 03; 28(3). PMID: 34064867    Free PMC article.
A Novel Three-Gene Score as a Predictive Biomarker for Pathologically Complete Response after Neoadjuvant Chemotherapy in Triple-Negative Breast Cancer.
Masanori Oshi, Fernando A Angarita, +4 authors, Kazuaki Takabe.
Cancers (Basel), 2021 Jun 03; 13(10). PMID: 34065619    Free PMC article.
Liquid Biopsy: A New Tool for Overcoming CDKi Resistance Mechanisms in Luminal Metastatic Breast Cancer.
Miriam González-Conde, Celso Yañez-Gómez, Rafael López-López, Clotilde Costa.
J Pers Med, 2021 Jun 03; 11(5). PMID: 34068388    Free PMC article.