Review
. 2018 Nov; 10(1):79.
doi: 10.1186/s13073-018-0588-4.

Recent advances in immunotherapies: from infection and autoimmunity, to cancer, and back again

Samantha L Bucktrout 1 Jeffrey A Bluestone 2 Fred Ramsdell 3 
Affiliations
  • PMID: 30376867
  •     99 References
  •     15 citations

Abstract

For at least 300 years the immune system has been targeted to improve human health. Decades of work advancing immunotherapies against infection and autoimmunity paved the way for the current explosion in cancer immunotherapies. Pathways targeted for therapeutic intervention in autoimmune diseases can be modulated in the opposite sense in malignancy and infectious disease. We discuss the basic principles of the immune response, how these are co-opted in chronic infection and malignancy, and how these can be harnessed to treat disease. T cells are at the center of immunotherapy. We consider the complexity of T cell functional subsets, differentiation states, and extrinsic and intrinsic influences in the design, success, and lessons from immunotherapies. The integral role of checkpoints in the immune response is highlighted by the rapid advances in FDA approvals and the use of therapeutics that target the CTLA-4 and PD-1/PD-L1 pathways. We discuss the distinct and overlapping mechanisms of CTLA-4 and PD-1 and how these can be translated to combination immunotherapy treatments. Finally, we discuss how the successes and challenges in cancer immunotherapies, such as the collateral damage of immune-related adverse events following checkpoint inhibition, are informing treatment of autoimmunity, infection, and malignancy.

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Front Immunol, 2020 Aug 15; 11. PMID: 32793241    Free PMC article.
Tick Salivary Compounds for Targeted Immunomodulatory Therapy.
Hajer Aounallah, Chaima Bensaoud, +3 authors, Michail Kotsyfakis.
Front Immunol, 2020 Oct 20; 11. PMID: 33072132    Free PMC article.
Review.
3D Immunocompetent Organ-on-a-Chip Models.
Sushila Maharjan, Berivan Cecen, Yu Shrike Zhang.
Small Methods, 2020 Oct 20; 4(9). PMID: 33072861    Free PMC article.
Combining Radiotherapy and Immunotherapy in Lung Cancer: Can We Expect Limitations Due to Altered Normal Tissue Toxicity?
Florian Wirsdörfer, Simone de Leve, Verena Jendrossek.
Int J Mol Sci, 2018 Dec 24; 20(1). PMID: 30577587    Free PMC article.
Review.
CD20-Mimotope Peptides: A Model to Define the Molecular Basis of Epitope Spreading.
Elvira Favoino, Marcella Prete, +2 authors, Federico Perosa.
Int J Mol Sci, 2019 Apr 21; 20(8). PMID: 31003532    Free PMC article.
Anti-PD1 therapy induces lymphocyte-derived exosomal miRNA-4315 release inhibiting Bim-mediated apoptosis of tumor cells.
Nina Guyon, Delphine Garnier, +8 authors, Pierre-François Cartron.
Cell Death Dis, 2020 Dec 15; 11(12). PMID: 33311449    Free PMC article.
Understanding and Managing Large B Cell Lymphoma Relapses after Chimeric Antigen Receptor T Cell Therapy.
Michael Byrne, Olalekan O Oluwole, +3 authors, Fredrick L Locke.
Biol Blood Marrow Transplant, 2019 Jul 08; 25(11). PMID: 31279751    Free PMC article.
Review.
Abscopal antitumor effect in a patient with melanoma and coronavirus disease 2019.
Hugo Herrscher, Benoit Sauer, Pierre Truntzer, Caroline Robert.
Eur J Cancer, 2021 Apr 12; 149. PMID: 33839589    Free PMC article.
Emerging glyco-based strategies to steer immune responses.
Marko Anderluh, Francesco Berti, +22 authors, Sandra J van Vliet.
FEBS J, 2021 Mar 23; 288(16). PMID: 33752265    Free PMC article.
Review.
Human inhibitory leukocyte Ig-like receptors: from immunotolerance to immunotherapy.
Calvin D De Louche, Ali Roghanian.
JCI Insight, 2022 Jan 26; 7(2). PMID: 35076022    Free PMC article.
Review.