Radiotherapy as a New Player in Immuno-Oncology

Shang-Jui Wang ¹, Bruce Haffty ²

Affiliations

¹ Department of Radiation Oncology, Rutgers Cancer Institute of New Jersey, 195 Little Albany St., New Brunswick, NJ 08901, USA. sjwang0416@gmail.com.
² Department of Radiation Oncology, Rutgers Cancer Institute of New Jersey, 195 Little Albany St., New Brunswick, NJ 08901, USA. hafftybg@cinj.rutgers.edu.

PMID: 30558196
142 References
6 citations

Abstract

Recent development in radiation biology has revealed potent immunogenic properties of radiotherapy in cancer treatments. However, antitumor immune effects of radiotherapy are limited by the concomitant induction of radiation-dependent immunosuppressive effects. In the growing era of immunotherapy, combining radiotherapy with immunomodulating agents has demonstrated enhancement of radiation-induced antitumor immune activation that correlated with improved treatment outcomes. Yet, how to optimally deliver combination therapy regarding dose-fractionation and timing of radiotherapy is largely unknown. Future prospective testing to fine-tune this promising combination of radiotherapy and immunotherapy is warranted.

Keywords: cancer; combination therapy; dose-fractionation; immunotherapy; radiation; radiotherapy; timing.

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