Review
. 2019 Jan;18(3).
doi: 10.1038/s41573-018-0006-z.

Delivery technologies for cancer immunotherapy

Rachel S Riley 1 Carl H June 2 Robert Langer 3 Michael J Mitchell 4 
Affiliations
  • PMID: 30622344
  •     238 References
  •     138 citations

Abstract

Immunotherapy has become a powerful clinical strategy for treating cancer. The number of immunotherapy drug approvals has been increasing, with numerous treatments in clinical and preclinical development. However, a key challenge in the broad implementation of immunotherapies for cancer remains the controlled modulation of the immune system, as these therapeutics have serious adverse effects including autoimmunity and nonspecific inflammation. Understanding how to increase the response rates to various classes of immunotherapy is key to improving efficacy and controlling these adverse effects. Advanced biomaterials and drug delivery systems, such as nanoparticles and the use of T cells to deliver therapies, could effectively harness immunotherapies and improve their potency while reducing toxic side effects. Here, we discuss these research advances, as well as the opportunities and challenges for integrating delivery technologies into cancer immunotherapy, and we critically analyse the outlook for these emerging areas.

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Correlation between Ferumoxytol Uptake in Tumor Lesions by MRI and Response to Nanoliposomal Irinotecan in Patients with Advanced Solid Tumors: A Pilot Study.
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Clin Cancer Res, 2017 Feb 06; 23(14). PMID: 28159813
Highly Cited.
Synapse-directed delivery of immunomodulators using T-cell-conjugated nanoparticles.
Matthias T Stephan, Sirkka B Stephan, +2 authors, Darrell J Irvine.
Biomaterials, 2012 May 19; 33(23). PMID: 22594972    Free PMC article.
Breakthrough of the year 2013. Cancer immunotherapy.
Jennifer Couzin-Frankel.
Science, 2013 Dec 21; 342(6165). PMID: 24357284
Highly Cited.
Use of Angiotensin System Inhibitors Is Associated with Immune Activation and Longer Survival in Nonmetastatic Pancreatic Ductal Adenocarcinoma.
Hao Liu, Kamila Naxerova, +22 authors, Rakesh K Jain.
Clin Cancer Res, 2017 Jun 11; 23(19). PMID: 28600474    Free PMC article.
Integrating Next-Generation Dendritic Cell Vaccines into the Current Cancer Immunotherapy Landscape.
Abhishek D Garg, Pierre G Coulie, Benoit J Van den Eynde, Patrizia Agostinis.
Trends Immunol, 2017 Jun 15; 38(8). PMID: 28610825
Highly Cited. Review.
Engineered T cells: the promise and challenges of cancer immunotherapy.
Andrew D Fesnak, Carl H June, Bruce L Levine.
Nat Rev Cancer, 2016 Aug 24; 16(9). PMID: 27550819    Free PMC article.
Highly Cited. Review.
The immunobiology of CD27 and OX40 and their potential as targets for cancer immunotherapy.
Sarah L Buchan, Anne Rogel, Aymen Al-Shamkhani.
Blood, 2017 Nov 10; 131(1). PMID: 29118006
Highly Cited. Review.
Sipuleucel-T in the treatment of prostate cancer: an evidence-based review of its place in therapy.
Julie N Graff, Erin D Chamberlain.
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Review.
Understanding the tumor immune microenvironment (TIME) for effective therapy.
Mikhail Binnewies, Edward W Roberts, +15 authors, Matthew F Krummel.
Nat Med, 2018 Apr 25; 24(5). PMID: 29686425    Free PMC article.
Highly Cited. Review.
Nanoparticle anchoring targets immune agonists to tumors enabling anti-cancer immunity without systemic toxicity.
Yuan Zhang, Na Li, Heikyung Suh, Darrell J Irvine.
Nat Commun, 2018 Jan 04; 9(1). PMID: 29295974    Free PMC article.
Highly Cited.
Treatment of hairy cell leukemia with recombinant alpha-interferon.
J R Quesada, E M Hersh, +5 authors, J U Gutterman.
Blood, 1986 Aug 01; 68(2). PMID: 3730612
Identification of immune factors regulating antitumor immunity using polymeric vaccines with multiple adjuvants.
Omar A Ali, Catia Verbeke, +6 authors, David J Mooney.
Cancer Res, 2014 Feb 01; 74(6). PMID: 24480625    Free PMC article.
Injectable cryogel-based whole-cell cancer vaccines.
Sidi A Bencherif, R Warren Sands, +8 authors, David J Mooney.
Nat Commun, 2015 Aug 13; 6. PMID: 26265369    Free PMC article.
Highly Cited.
Pharmacokinetics of recombinant human interleukin-2 in advanced renal cell carcinoma patients following subcutaneous application.
G I Kirchner, A Franzke, +9 authors, J Atzpodien.
Br J Clin Pharmacol, 1998 Aug 05; 46(1). PMID: 9690943    Free PMC article.
Phase Ib Study of Utomilumab (PF-05082566), a 4-1BB/CD137 Agonist, in Combination with Pembrolizumab (MK-3475) in Patients with Advanced Solid Tumors.
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Clin Cancer Res, 2017 Jun 22; 23(18). PMID: 28634283
Highly Cited.
PD-1 and PD-L1 Checkpoint Signaling Inhibition for Cancer Immunotherapy: Mechanism, Combinations, and Clinical Outcome.
Hashem O Alsaab, Samaresh Sau, +4 authors, Arun K Iyer.
Front Pharmacol, 2017 Sep 08; 8. PMID: 28878676    Free PMC article.
Highly Cited. Review.
Therapeutic cancer vaccines: past, present, and future.
Chunqing Guo, Masoud H Manjili, +3 authors, Xiang-Yang Wang.
Adv Cancer Res, 2013 Jul 23; 119. PMID: 23870514    Free PMC article.
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Michael J Mitchell, Elizabeth Wayne, +2 authors, Michael R King.
Proc Natl Acad Sci U S A, 2014 Jan 08; 111(3). PMID: 24395803    Free PMC article.
Highly Cited.
The Principles of Engineering Immune Cells to Treat Cancer.
Wendell A Lim, Carl H June.
Cell, 2017 Feb 12; 168(4). PMID: 28187291    Free PMC article.
Highly Cited. Review.
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T Keler, L He, V Ramakrishna, B Champion.
Oncogene, 2007 May 29; 26(25). PMID: 17530028
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Nat Mater, 2018 Mar 07; 17(6). PMID: 29507416    Free PMC article.
Highly Cited.
Microneedle-array patches loaded with hypoxia-sensitive vesicles provide fast glucose-responsive insulin delivery.
Jicheng Yu, Yuqi Zhang, +6 authors, Zhen Gu.
Proc Natl Acad Sci U S A, 2015 Jun 24; 112(27). PMID: 26100900    Free PMC article.
Highly Cited.
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Hao Yin, Rosemary L Kanasty, +3 authors, Daniel G Anderson.
Nat Rev Genet, 2014 Jul 16; 15(8). PMID: 25022906
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L Li, S P Goedegebuure, W E Gillanders.
Ann Oncol, 2017 Dec 19; 28(suppl_12). PMID: 29253113    Free PMC article.
Review.
The cancer vaccine resurgence.
Asher Mullard.
Nat Rev Drug Discov, 2016 Sep 30; 15(10). PMID: 27681782
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Kevin J Kauffman, Matthew J Webber, Daniel G Anderson.
J Control Release, 2016 Jan 01; 240. PMID: 26718856
Highly Cited. Review.
Preclinical mouse cancer models: a maze of opportunities and challenges.
Chi-Ping Day, Glenn Merlino, Terry Van Dyke.
Cell, 2015 Sep 26; 163(1). PMID: 26406370    Free PMC article.
Highly Cited. Review.
Engineered CAR T Cells Targeting the Cancer-Associated Tn-Glycoform of the Membrane Mucin MUC1 Control Adenocarcinoma.
Avery D Posey, Robert D Schwab, +19 authors, Carl H June.
Immunity, 2016 Jun 23; 44(6). PMID: 27332733    Free PMC article.
Highly Cited.
Inflammatory cytokines presented from polymer matrices differentially generate and activate DCs in situ.
Omar A Ali, Prakriti Tayalia, +2 authors, David J Mooney.
Adv Funct Mater, 2014 Apr 02; 23(36). PMID: 24688455    Free PMC article.
Interferon gamma stimulates cellular maturation of dendritic cell line DC2.4 leading to induction of efficient cytotoxic T cell responses and antitumor immunity.
Tianpei He, Chaoke Tang, +2 authors, Jim Xiang.
Cell Mol Immunol, 2007 May 09; 4(2). PMID: 17484804
Bispecific antibodies for cancer therapy: A review.
Anuradha Krishnamurthy, Antonio Jimeno.
Pharmacol Ther, 2017 Dec 23; 185. PMID: 29269044
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Lympho-geographical concepts in vaccine delivery.
Pål Johansen, Deepa Mohanan, +2 authors, Bruno Gander.
J Control Release, 2010 Jun 22; 148(1). PMID: 20562028
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Synergistic Transcutaneous Immunotherapy Enhances Antitumor Immune Responses through Delivery of Checkpoint Inhibitors.
Yanqi Ye, Jinqiang Wang, +4 authors, Zhen Gu.
ACS Nano, 2016 Sep 07; 10(9). PMID: 27599066
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Crit Rev Oncol Hematol, 2017 Jul 12; 116. PMID: 28693793
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Type I Interferons and Natural Killer Cell Regulation in Cancer.
Lena Müller, Petra Aigner, Dagmar Stoiber.
Front Immunol, 2017 Apr 15; 8. PMID: 28408907    Free PMC article.
Review.
A Light Responsive Nanoparticle-Based Delivery System Using Pheophorbide A Graft Polyethylenimine for Dendritic Cell-Based Cancer Immunotherapy.
Chuangnian Zhang, Ju Zhang, +9 authors, Chen Li.
Mol Pharm, 2017 Mar 16; 14(5). PMID: 28296410
Treatment of metastatic renal cell carcinoma with CAIX CAR-engineered T cells: clinical evaluation and management of on-target toxicity.
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Mol Ther, 2013 Feb 21; 21(4). PMID: 23423337    Free PMC article.
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Robert H Vonderheide, Keith T Flaherty, +12 authors, Scott J Antonia.
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Genome-Editing Technologies in Adoptive T Cell Immunotherapy for Cancer.
Nathan Singh, Junwei Shi, Carl H June, Marco Ruella.
Curr Hematol Malig Rep, 2017 Oct 19; 12(6). PMID: 29039115    Free PMC article.
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Michael Croft.
Nat Rev Immunol, 2003 Sep 17; 3(8). PMID: 12974476
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Omar A Ali, Nathaniel Huebsch, +2 authors, David J Mooney.
Nat Mater, 2009 Jan 13; 8(2). PMID: 19136947    Free PMC article.
Highly Cited.
mRNA vaccines - a new era in vaccinology.
Norbert Pardi, Michael J Hogan, Frederick W Porter, Drew Weissman.
Nat Rev Drug Discov, 2018 Jan 13; 17(4). PMID: 29326426    Free PMC article.
Highly Cited. Review.
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Alberto Mantovani, Paola Allavena, Antonio Sica, Frances Balkwill.
Nature, 2008 Jul 25; 454(7203). PMID: 18650914
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Recent Advances in Subunit Vaccine Carriers.
Abhishek Vartak, Steven J Sucheck.
Vaccines (Basel), 2016 Apr 23; 4(2). PMID: 27104575    Free PMC article.
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Enhanced Cancer Immunotherapy by Microneedle Patch-Assisted Delivery of Anti-PD1 Antibody.
Chao Wang, Yanqi Ye, +2 authors, Zhen Gu.
Nano Lett, 2016 Mar 22; 16(4). PMID: 26999507
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Is autoimmunity the Achilles' heel of cancer immunotherapy?
Carl H June, Jeremy T Warshauer, Jeffrey A Bluestone.
Nat Med, 2017 May 06; 23(5). PMID: 28475571
Highly Cited.
Chimeric Antigen Receptor T Cells in Refractory B-Cell Lymphomas.
Stephen J Schuster, Jakub Svoboda, +13 authors, Carl H June.
N Engl J Med, 2017 Dec 12; 377(26). PMID: 29226764    Free PMC article.
Highly Cited.
RNA-Based Vaccines in Cancer Immunotherapy.
Megan A McNamara, Smita K Nair, Eda K Holl.
J Immunol Res, 2015 Dec 15; 2015. PMID: 26665011    Free PMC article.
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S Nayak, R W Herzog.
Gene Ther, 2009 Nov 13; 17(3). PMID: 19907498    Free PMC article.
Highly Cited. Review.
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Serena K Perna, Daria Pagliara, +4 authors, Gianpietro Dotti.
Clin Cancer Res, 2013 Oct 08; 20(1). PMID: 24097874    Free PMC article.
A carbon nanotube-polymer composite for T-cell therapy.
Tarek R Fadel, Fiona A Sharp, +11 authors, Tarek M Fahmy.
Nat Nanotechnol, 2014 Aug 05; 9(8). PMID: 25086604
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Delivering safer immunotherapies for cancer.
Lauren Milling, Yuan Zhang, Darrell J Irvine.
Adv Drug Deliv Rev, 2017 May 27; 114. PMID: 28545888    Free PMC article.
Highly Cited. Review.
Polymeric nanoparticles for nonviral gene therapy extend brain tumor survival in vivo.
Antonella Mangraviti, Stephany Yi Tzeng, +15 authors, Jordan J Green.
ACS Nano, 2015 Feb 03; 9(2). PMID: 25643235    Free PMC article.
Highly Cited.
Chimeric antigen receptor therapy for cancer.
David M Barrett, Nathan Singh, +2 authors, Carl H June.
Annu Rev Med, 2013 Nov 28; 65. PMID: 24274181    Free PMC article.
Highly Cited. Review.
Lipid Nanoparticle Assisted mRNA Delivery for Potent Cancer Immunotherapy.
Matthias A Oberli, Andreas M Reichmuth, +6 authors, Daniel Blankschtein.
Nano Lett, 2017 Mar 10; 17(3). PMID: 28273716    Free PMC article.
Highly Cited.
Injectable, porous, and cell-responsive gelatin cryogels.
Sandeep T Koshy, Thomas C Ferrante, Sarah A Lewin, David J Mooney.
Biomaterials, 2013 Dec 19; 35(8). PMID: 24345735    Free PMC article.
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Blood, 2009 Jul 17; 114(12). PMID: 19605850    Free PMC article.
Highly Cited.
E-selectin liposomal and nanotube-targeted delivery of doxorubicin to circulating tumor cells.
Michael J Mitchell, Christina S Chen, +2 authors, Michael R King.
J Control Release, 2012 Mar 17; 160(3). PMID: 22421423    Free PMC article.
Mechanisms of action and rationale for the use of checkpoint inhibitors in cancer.
Clemence Granier, Eleonore De Guillebon, +7 authors, Eric Tartour.
ESMO Open, 2017 Aug 02; 2(2). PMID: 28761757    Free PMC article.
Highly Cited. Review.
Cancer nanomedicine: from targeted delivery to combination therapy.
Xiaoyang Xu, William Ho, +2 authors, Omid Farokhzad.
Trends Mol Med, 2015 Feb 07; 21(4). PMID: 25656384    Free PMC article.
Highly Cited. Review.
Intrinsic immunogenicity of rapidly-degradable polymers evolves during degradation.
James I Andorko, Krystina L Hess, Kevin G Pineault, Christopher M Jewell.
Acta Biomater, 2015 Dec 29; 32. PMID: 26708710    Free PMC article.
Durable complete responses in heavily pretreated patients with metastatic melanoma using T-cell transfer immunotherapy.
Steven A Rosenberg, James C Yang, +12 authors, Mark E Dudley.
Clin Cancer Res, 2011 Apr 19; 17(13). PMID: 21498393    Free PMC article.
Highly Cited.
T cell exclusion, immune privilege, and the tumor microenvironment.
Johanna A Joyce, Douglas T Fearon.
Science, 2015 Apr 04; 348(6230). PMID: 25838376
Highly Cited. Review.
Chimeric antigen receptor T cells persist and induce sustained remissions in relapsed refractory chronic lymphocytic leukemia.
David L Porter, Wei-Ting Hwang, +15 authors, Carl H June.
Sci Transl Med, 2015 Sep 04; 7(303). PMID: 26333935    Free PMC article.
Highly Cited.
Immunization with cocktail of HIV-derived peptides in montanide ISA-51 is immunogenic, but causes sterile abscesses and unacceptable reactogenicity.
Barney S Graham, M Juliana McElrath, +14 authors, AIDS Vaccine Evaluation Group.
PLoS One, 2010 Aug 14; 5(8). PMID: 20706632    Free PMC article.
Cytokines in cancer immunotherapy.
Sylvia Lee, Kim Margolin.
Cancers (Basel), 2011 Jan 01; 3(4). PMID: 24213115    Free PMC article.
Highly Cited.
The role of IL-10 in human B cell activation, proliferation, and differentiation.
K Itoh, S Hirohata.
J Immunol, 1995 May 01; 154(9). PMID: 7722292
The efficacy of intracranial PLG-based vaccines is dependent on direct implantation into brain tissue.
Omar A Ali, Edward Doherty, +5 authors, Dwaine F Emerich.
J Control Release, 2011 Jun 28; 154(3). PMID: 21704093
The pharmacokinetics of Toll-like receptor agonists and the impact on the immune system.
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Expert Rev Clin Pharmacol, 2011 Jun 07; 4(2). PMID: 21643519    Free PMC article.
Review.
A single dose of peripherally infused EGFRvIII-directed CAR T cells mediates antigen loss and induces adaptive resistance in patients with recurrent glioblastoma.
Donald M O'Rourke, MacLean P Nasrallah, +18 authors, Marcela V Maus.
Sci Transl Med, 2017 Jul 21; 9(399). PMID: 28724573    Free PMC article.
Highly Cited.
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Ton N Schumacher, Robert D Schreiber.
Science, 2015 Apr 04; 348(6230). PMID: 25838375
Highly Cited. Review.
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Jatta Huotari, Ari Helenius.
EMBO J, 2011 Sep 01; 30(17). PMID: 21878991    Free PMC article.
Highly Cited. Review.
The benefits of immunotherapy combinations.
Charles Schmidt.
Nature, 2018 Jan 03; 552(7685). PMID: 29293245
A vector-free microfluidic platform for intracellular delivery.
Armon Sharei, Janet Zoldan, +17 authors, Klavs F Jensen.
Proc Natl Acad Sci U S A, 2013 Jan 24; 110(6). PMID: 23341631    Free PMC article.
Highly Cited.
Fc-dependent depletion of tumor-infiltrating regulatory T cells co-defines the efficacy of anti-CTLA-4 therapy against melanoma.
Tyler R Simpson, Fubin Li, +11 authors, Sergio A Quezada.
J Exp Med, 2013 Jul 31; 210(9). PMID: 23897981    Free PMC article.
Highly Cited.
Immune suppressive mechanisms in the tumor microenvironment.
David H Munn, Vincenzo Bronte.
Curr Opin Immunol, 2015 Nov 27; 39. PMID: 26609943    Free PMC article.
Highly Cited. Review.
Interferon in the treatment of hairy-cell leukemia.
Shahid Ahmed, Kanti R Rai.
Best Pract Res Clin Haematol, 2003 Apr 03; 16(1). PMID: 12670466
Review.
DNA vaccines: an historical perspective and view to the future.
Margaret A Liu.
Immunol Rev, 2011 Jan 05; 239(1). PMID: 21198665
Highly Cited. Review.
Safety, tumor trafficking and immunogenicity of chimeric antigen receptor (CAR)-T cells specific for TAG-72 in colorectal cancer.
Kristen M Hege, Emily K Bergsland, +7 authors, Stephen A Sherwin.
J Immunother Cancer, 2017 Mar 28; 5. PMID: 28344808    Free PMC article.
Highly Cited.
The blockade of immune checkpoints in cancer immunotherapy.
Drew M Pardoll.
Nat Rev Cancer, 2012 Mar 23; 12(4). PMID: 22437870    Free PMC article.
Highly Cited. Review.
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J Clin Invest, 2017 Apr 25; 127(6). PMID: 28436934    Free PMC article.
Highly Cited.
pH-Responsive nanoparticle vaccines for dual-delivery of antigens and immunostimulatory oligonucleotides.
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ACS Nano, 2013 Apr 18; 7(5). PMID: 23590591    Free PMC article.
Highly Cited.
Human CD26high T cells elicit tumor immunity against multiple malignancies via enhanced migration and persistence.
Stefanie R Bailey, Michelle H Nelson, +9 authors, Chrystal M Paulos.
Nat Commun, 2017 Dec 08; 8(1). PMID: 29213079    Free PMC article.
Endothelial Activation and Blood-Brain Barrier Disruption in Neurotoxicity after Adoptive Immunotherapy with CD19 CAR-T Cells.
Juliane Gust, Kevin A Hay, +15 authors, Cameron J Turtle.
Cancer Discov, 2017 Oct 14; 7(12). PMID: 29025771    Free PMC article.
Highly Cited.
Comparison of acute toxicity and mortality after two different dosing regimens of high-dose interleukin-2 for patients with metastatic melanoma.
Laura M Alwan, Kenneth Grossmann, +3 authors, Jeffrey A Gilreath.
Target Oncol, 2013 Apr 24; 9(1). PMID: 23609056
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K Ramani, Q Hassan, +2 authors, D P Sarkar.
Proc Natl Acad Sci U S A, 1998 Sep 30; 95(20). PMID: 9751760    Free PMC article.
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Derek W Bartlett, Helen Su, +2 authors, Mark E Davis.
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Highly Cited.
Sipuleucel-T immunotherapy for castration-resistant prostate cancer.
Philip W Kantoff, Celestia S Higano, +11 authors, IMPACT Study Investigators.
N Engl J Med, 2010 Sep 08; 363(5). PMID: 20818862
Highly Cited.
Inhibition of tumor angiogenesis by interferon-γ by suppression of tumor-associated macrophage differentiation.
Tao Sun, Ye Yang, +4 authors, Chunlin Ge.
Oncol Res, 2014 May 24; 21(5). PMID: 24854099
Immune signatures of murine and human cancers reveal unique mechanisms of tumor escape and new targets for cancer immunotherapy.
Rebecca E Sadun, Suzanne M Sachsman, +4 authors, Alan L Epstein.
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Allogeneic tumor cell vaccines: the promise and limitations in clinical trials.
Sanjay Srivatsan, Jaina M Patel, +4 authors, Periasamy Selvaraj.
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Highly Cited.
Recent progress in GM-CSF-based cancer immunotherapy.
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Review.
Augmentation of Antitumor Immunity by Human and Mouse CAR T Cells Secreting IL-18.
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Highly Cited.
Cardiovascular toxicity and titin cross-reactivity of affinity-enhanced T cells in myeloma and melanoma.
Gerald P Linette, Edward A Stadtmauer, +20 authors, Carl H June.
Blood, 2013 Jun 19; 122(6). PMID: 23770775    Free PMC article.
Highly Cited.
Pneumonitis in Patients Treated With Anti-Programmed Death-1/Programmed Death Ligand 1 Therapy.
Jarushka Naidoo, Xuan Wang, +26 authors, Matthew D Hellmann.
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Highly Cited.
Current Trends and Challenges in the Clinical Translation of Nanoparticulate Nanomedicines: Pathways for Translational Development and Commercialization.
Susan Hua, Maria B C de Matos, Josbert M Metselaar, Gert Storm.
Front Pharmacol, 2018 Aug 02; 9. PMID: 30065653    Free PMC article.
Highly Cited. Review.
Cancer immunotherapy using checkpoint blockade.
Antoni Ribas, Jedd D Wolchok.
Science, 2018 Mar 24; 359(6382). PMID: 29567705    Free PMC article.
Highly Cited. Review.
Injectable, spontaneously assembling, inorganic scaffolds modulate immune cells in vivo and increase vaccine efficacy.
Jaeyun Kim, Weiwei Aileen Li, +4 authors, David J Mooney.
Nat Biotechnol, 2014 Dec 09; 33(1). PMID: 25485616    Free PMC article.
Highly Cited.
A phase I study on adoptive immunotherapy using gene-modified T cells for ovarian cancer.
Michael H Kershaw, Jennifer A Westwood, +11 authors, Patrick Hwu.
Clin Cancer Res, 2006 Oct 26; 12(20 Pt 1). PMID: 17062687    Free PMC article.
Highly Cited.
Bioreducible Polymeric Nanoparticles Containing Multiplexed Cancer Stem Cell Regulating miRNAs Inhibit Glioblastoma Growth and Prolong Survival.
Hernando Lopez-Bertoni, Kristen L Kozielski, +7 authors, Jordan J Green.
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Highly Cited.
CD19-Targeted CAR T cells as novel cancer immunotherapy for relapsed or refractory B-cell acute lymphoblastic leukemia.
Marco L Davila, Renier J Brentjens.
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Review.
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Sattva S Neelapu, Frederick L Locke, +37 authors, William Y Go.
N Engl J Med, 2017 Dec 12; 377(26). PMID: 29226797    Free PMC article.
Highly Cited.
Soluble and membrane-bound interleukin (IL)-15 Rα/IL-15 complexes mediate proliferation of high-avidity central memory CD8+ T cells for adoptive immunotherapy of cancer and infections.
A N Hasan, A Selvakumar, +7 authors, R J O'Reilly.
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Controlled local delivery of CTLA-4 blocking antibody induces CD8+ T-cell-dependent tumor eradication and decreases risk of toxic side effects.
Marieke F Fransen, Tetje C van der Sluis, +2 authors, Cornelis J M Melief.
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Adoptive cell transfer as personalized immunotherapy for human cancer.
Steven A Rosenberg, Nicholas P Restifo.
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Highly Cited. Review.
Efficiency of siRNA delivery by lipid nanoparticles is limited by endocytic recycling.
Gaurav Sahay, William Querbes, +11 authors, Daniel G Anderson.
Nat Biotechnol, 2013 Jun 25; 31(7). PMID: 23792629    Free PMC article.
Highly Cited.
Immune checkpoint inhibitors in cancer therapy.
Eika S Webb, Peng Liu, +3 authors, Yao-He Wang.
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Stephan A Grupp, Michael Kalos, +10 authors, Carl H June.
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Highly Cited.
Acquired resistance to immunotherapy and future challenges.
Nicholas P Restifo, Mark J Smyth, Alexandra Snyder.
Nat Rev Cancer, 2016 Jan 30; 16(2). PMID: 26822578    Free PMC article.
Highly Cited.
Whole Tumor Antigen Vaccines: Where Are We?
Cheryl Lai-Lai Chiang, George Coukos, Lana E Kandalaft.
Vaccines (Basel), 2015 Sep 08; 3(2). PMID: 26343191    Free PMC article.
Review.
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Highly Cited.
Oncolytic Viruses in Cancer Treatment: A Review.
Sean E Lawler, Maria-Carmela Speranza, Choi-Fong Cho, E Antonio Chiocca.
JAMA Oncol, 2016 Jul 22; 3(6). PMID: 27441411
Highly Cited. Review.
Overcoming the Immunosuppressive Tumor Microenvironment of Hodgkin Lymphoma Using Chimeric Antigen Receptor T Cells.
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Cancer Discov, 2017 Jun 04; 7(10). PMID: 28576927    Free PMC article.
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Cliff Wong, Triantafyllos Stylianopoulos, +7 authors, Dai Fukumura.
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Cancer nanotechnology: the impact of passive and active targeting in the era of modern cancer biology.
Nicolas Bertrand, Jun Wu, +2 authors, Omid C Farokhzad.
Adv Drug Deliv Rev, 2013 Nov 26; 66. PMID: 24270007    Free PMC article.
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Synthesis, characterization, and evaluation of ionizable lysine-based lipids for siRNA delivery.
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Bioconjug Chem, 2012 Nov 28; 24(1). PMID: 23176544    Free PMC article.
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Kelly D Moynihan, Cary F Opel, +19 authors, Darrell J Irvine.
Nat Med, 2016 Nov 01; 22(12). PMID: 27775706    Free PMC article.
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Optimization of Lipid Nanoparticle Formulations for mRNA Delivery in Vivo with Fractional Factorial and Definitive Screening Designs.
Kevin J Kauffman, J Robert Dorkin, +5 authors, Daniel G Anderson.
Nano Lett, 2015 Oct 16; 15(11). PMID: 26469188
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64Cu-MM-302 Positron Emission Tomography Quantifies Variability of Enhanced Permeability and Retention of Nanoparticles in Relation to Treatment Response in Patients with Metastatic Breast Cancer.
Helen Lee, Anthony F Shields, +14 authors, Bart S Hendriks.
Clin Cancer Res, 2017 Mar 17; 23(15). PMID: 28298546    Free PMC article.
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Anti-tumor Activity of Toll-Like Receptor 7 Agonists.
Huju Chi, Chunman Li, +4 authors, Ou Sha.
Front Pharmacol, 2017 Jun 18; 8. PMID: 28620298    Free PMC article.
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Toxicity of cationic lipids and cationic polymers in gene delivery.
Hongtao Lv, Shubiao Zhang, +2 authors, Jie Yan.
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Application of PD-1 Blockade in Cancer Immunotherapy.
Xiaomo Wu, Zhongkai Gu, +4 authors, Xiaolong Liu.
Comput Struct Biotechnol J, 2019 Jun 18; 17. PMID: 31205619    Free PMC article.
Highly Cited. Review.
Novel Delivery Systems for Checkpoint Inhibitors.
Purushottam Lamichhane, Rahul Deshmukh, +8 authors, Narottam Lamichhane.
Medicines (Basel), 2019 Aug 03; 6(3). PMID: 31373327    Free PMC article.
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Interactions of Nanoparticles and Biosystems: Microenvironment of Nanoparticles and Biomolecules in Nanomedicine.
Carlota Auría-Soro, Tabata Nesma, +7 authors, Manuel Fuentes.
Nanomaterials (Basel), 2019 Sep 27; 9(10). PMID: 31554176    Free PMC article.
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The Evolving Landscape of Biomarkers for Anti-PD-1 or Anti-PD-L1 Therapy.
Antje Tunger, Ulrich Sommer, +7 authors, Marc Schmitz.
J Clin Med, 2019 Sep 29; 8(10). PMID: 31557787    Free PMC article.
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Emergent Nanotechnological Strategies for Systemic Chemotherapy against Melanoma.
Jacinta Oliveira Pinho, Mariana Matias, Maria Manuela Gaspar.
Nanomaterials (Basel), 2019 Oct 17; 9(10). PMID: 31614947    Free PMC article.
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Emerging modes-of-action in drug discovery.
Eric Valeur, Frank Narjes, Christian Ottmann, Alleyn T Plowright.
Medchemcomm, 2019 Nov 02; 10(9). PMID: 31673315    Free PMC article.
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Red blood cell-derived nanoerythrosome for antigen delivery with enhanced cancer immunotherapy.
Xiao Han, Shufang Shen, +6 authors, Chao Wang.
Sci Adv, 2019 Nov 05; 5(10). PMID: 31681841    Free PMC article.
Recent advances and challenges of repurposing nanoparticle-based drug delivery systems to enhance cancer immunotherapy.
Seungho Lim, Jooho Park, +5 authors, Kwangmeyung Kim.
Theranostics, 2019 Nov 07; 9(25). PMID: 31695807    Free PMC article.
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Advances in Engineering Cells for Cancer Immunotherapy.
Xiao Xu, Teng Li, +4 authors, Ran Mo.
Theranostics, 2019 Nov 07; 9(25). PMID: 31695806    Free PMC article.
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Intracellular tracking of drug release from pH-sensitive polymeric nanoparticles via FRET for synergistic chemo-photodynamic therapy.
Chen Du, Yan Liang, +7 authors, Yong Sun.
J Nanobiotechnology, 2019 Nov 09; 17(1). PMID: 31699100    Free PMC article.
Engineering Nanoparticles to Reprogram the Tumor Immune Microenvironment for Improved Cancer Immunotherapy.
Madiha Saeed, Jing Gao, +2 authors, Haijun Yu.
Theranostics, 2019 Nov 23; 9(26). PMID: 31754376    Free PMC article.
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Recruitment of CD103+ dendritic cells via tumor-targeted chemokine delivery enhances efficacy of checkpoint inhibitor immunotherapy.
John-Michael Williford, Jun Ishihara, +6 authors, Jeffrey A Hubbell.
Sci Adv, 2019 Dec 18; 5(12). PMID: 31844672    Free PMC article.
Overview of Immune Checkpoint Inhibitors Therapy for Hepatocellular Carcinoma, and The ITA.LI.CA Cohort Derived Estimate of Amenability Rate to Immune Checkpoint Inhibitors in Clinical Practice.
Edoardo G Giannini, Andrea Aglitti, +15 authors, Associazione Italiana per lo Studio del Fegato (AISF) HCC Special Interest Group.
Cancers (Basel), 2019 Nov 02; 11(11). PMID: 31671581    Free PMC article.
Review.
Decellularized Lymph Node Scaffolding as a Carrier for Dendritic Cells to Induce Anti-Tumor Immunity.
Hung-Jun Lin, Weu Wang, +4 authors, Der-Zen Liu.
Pharmaceutics, 2019 Nov 14; 11(11). PMID: 31717826    Free PMC article.
Nanoparticles versus Dendritic Cells as Vehicles to Deliver mRNA Encoding Multiple Epitopes for Immunotherapy.
Rebuma Firdessa-Fite, Rémi J Creusot.
Mol Ther Methods Clin Dev, 2019 Dec 25; 16. PMID: 31871957    Free PMC article.
Polymeric Nanocarrier Formulations of Biologics Using Inverse Flash NanoPrecipitation.
Chester E Markwalter, Robert F Pagels, +3 authors, Robert K Prud'homme.
AAPS J, 2020 Jan 04; 22(2). PMID: 31897899
The potential mechanism, recognition and clinical significance of tumor pseudoprogression after immunotherapy.
Wenxiao Jia, Qianqian Gao, +2 authors, Jinming Yu.
Cancer Biol Med, 2020 Jan 08; 16(4). PMID: 31908886    Free PMC article.
The Genomic Landscape of Antigenic Targets for T Cell-Based Leukemia Immunotherapy.
Marie-Pierre Hardy, Krystel Vincent, Claude Perreault.
Front Immunol, 2020 Jan 11; 10. PMID: 31921187    Free PMC article.
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Peptide-based targeting of immunosuppressive cells in cancer.
Noah T Trac, Eun Ji Chung.
Bioact Mater, 2020 Jan 21; 5(1). PMID: 31956738    Free PMC article.
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Highly efficient and tumor-selective nanoparticles for dual-targeted immunogene therapy against cancer.
Kuan-Wei Huang, Fu-Fei Hsu, +17 authors, Yunching Chen.
Sci Adv, 2020 Jan 31; 6(3). PMID: 31998834    Free PMC article.
Exploiting Current Understanding of Hypoxia Mediated Tumour Progression for Nanotherapeutic Development.
Jie Feng, Niall M Byrne, Wafa Al Jamal, Jonathan A Coulter.
Cancers (Basel), 2019 Dec 15; 11(12). PMID: 31835751    Free PMC article.
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Sequential MR Image-Guided Local Immune Checkpoint Blockade Cancer Immunotherapy Using Ferumoxytol Capped Ultralarge Pore Mesoporous Silica Carriers after Standard Chemotherapy.
Bongseo Choi, Huijin Jung, +3 authors, Dong-Hyun Kim.
Small, 2019 Nov 08; 15(52). PMID: 31697036    Free PMC article.
Ionizable lipid nanoparticles encapsulating barcoded mRNA for accelerated in vivo delivery screening.
Pedro P G Guimaraes, Rui Zhang, +8 authors, Michael J Mitchell.
J Control Release, 2019 Nov 05; 316. PMID: 31678653    Free PMC article.
Dual pH-sensitive nanodrug blocks PD-1 immune checkpoint and uses T cells to deliver NF-κB inhibitor for antitumor immunotherapy.
Zecong Xiao, Zhenwei Su, +3 authors, Xintao Shuai.
Sci Adv, 2020 Feb 23; 6(6). PMID: 32076650    Free PMC article.
Cell Membrane-Camouflaged Nanocarriers for Cancer Diagnostic and Therapeutic.
Shengxian Li, Jianhua Liu, +3 authors, Yinghao Sun.
Front Pharmacol, 2020 Mar 03; 11. PMID: 32116701    Free PMC article.
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T Cell Dysfunction and Exhaustion in Cancer.
Zhen Zhang, Shasha Liu, +3 authors, Yi Zhang.
Front Cell Dev Biol, 2020 Mar 03; 8. PMID: 32117960    Free PMC article.
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Integrating nanomedicine into clinical radiotherapy regimens.
Allison N DuRoss, Megan J Neufeld, +2 authors, Conroy Sun.
Adv Drug Deliv Rev, 2019 Jul 08; 144. PMID: 31279729    Free PMC article.
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Syringeable immunotherapeutic nanogel reshapes tumor microenvironment and prevents tumor metastasis and recurrence.
Chanyoung Song, Hathaichanok Phuengkham, +13 authors, Yong Taik Lim.
Nat Commun, 2019 Aug 23; 10(1). PMID: 31431623    Free PMC article.
Engineered Nanodelivery Systems to Improve DNA Vaccine Technologies.
Michael Lim, Abu Zayed Md Badruddoza, +5 authors, Mohammad Ariful Islam.
Pharmaceutics, 2020 Jan 08; 12(1). PMID: 31906277    Free PMC article.
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Characteristics of Tumor-Infiltrating Lymphocytes Prior to and During Immune Checkpoint Inhibitor Therapy.
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Front Immunol, 2020 Mar 21; 11. PMID: 32194568    Free PMC article.
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Recent advances in tumor associated carbohydrate antigen based chimeric antigen receptor T cells and bispecific antibodies for anti-cancer immunotherapy.
Zahra Rashidijahanabad, Xuefei Huang.
Semin Immunol, 2020 Jan 27; 47. PMID: 31982247    Free PMC article.
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Nanoparticles for nucleic acid delivery: Applications in cancer immunotherapy.
Alvin J Mukalel, Rachel S Riley, Rui Zhang, Michael J Mitchell.
Cancer Lett, 2019 May 18; 458. PMID: 31100411    Free PMC article.
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Near-infrared responsive 5-fluorouracil and indocyanine green loaded MPEG-PCL nanoparticle integrated with dissolvable microneedle for skin cancer therapy.
Ying Hao, YuWen Chen, +5 authors, ZhiYong Qian.
Bioact Mater, 2020 Apr 30; 5(3). PMID: 32346657    Free PMC article.
Emerging Prospects for Nanoparticle-Enabled Cancer Immunotherapy.
Manal Ali Buabeid, El-Shaimaa A Arafa, Ghulam Murtaza.
J Immunol Res, 2020 May 08; 2020. PMID: 32377541    Free PMC article.
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Smart cancer nanomedicine.
Roy van der Meel, Einar Sulheim, +3 authors, Twan Lammers.
Nat Nanotechnol, 2019 Nov 07; 14(11). PMID: 31695150    Free PMC article.
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Overcoming resistance to anti-PD1 and anti-PD-L1 treatment in gastrointestinal malignancies.
Alberto Puccini, Francesca Battaglin, +2 authors, Mohamed E Salem.
J Immunother Cancer, 2020 May 13; 8(1). PMID: 32393474    Free PMC article.
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Computational stabilization of T cell receptors allows pairing with antibodies to form bispecifics.
Karen Froning, Jack Maguire, +14 authors, Stephen J Demarest.
Nat Commun, 2020 May 13; 11(1). PMID: 32393818    Free PMC article.
The solid progress of nanomedicine.
João Pedro Martins, José das Neves, +10 authors, Hélder A Santos.
Drug Deliv Transl Res, 2020 Mar 07; 10(3). PMID: 32141035    Free PMC article.
Green Tea Polyphenol EGCG Attenuates MDSCs-mediated Immunosuppression through Canonical and Non-Canonical Pathways in a 4T1 Murine Breast Cancer Model.
Ping Xu, Feng Yan, +4 authors, Le Ying.
Nutrients, 2020 Apr 16; 12(4). PMID: 32290071    Free PMC article.
A guide to cancer immunotherapy: from T cell basic science to clinical practice.
Alex D Waldman, Jill M Fritz, Michael J Lenardo.
Nat Rev Immunol, 2020 May 21; 20(11). PMID: 32433532    Free PMC article.
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Messenger RNA delivery by hydrazone-activated polymers.
Marisa Juanes, Oliver Creese, Paco Fernández-Trillo, Javier Montenegro.
Medchemcomm, 2019 Aug 09; 10(7). PMID: 31391886    Free PMC article.
Adenovirus and Immunotherapy: Advancing Cancer Treatment by Combination.
Mizuho Sato-Dahlman, Christopher J LaRocca, Chikako Yanagiba, Masato Yamamoto.
Cancers (Basel), 2020 May 28; 12(5). PMID: 32455560    Free PMC article.
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Ionizable Lipid Nanoparticle-Mediated mRNA Delivery for Human CAR T Cell Engineering.
Margaret M Billingsley, Nathan Singh, +3 authors, Michael J Mitchell.
Nano Lett, 2020 Jan 18; 20(3). PMID: 31951421    Free PMC article.
An approach using Caenorhabditis elegans screening novel targets to suppress tumour cell proliferation.
Yu-Qin Mao, San-Feng Han, +7 authors, Li-Shun Wang.
Cell Prolif, 2020 May 27; 53(6). PMID: 32452127    Free PMC article.
The Relevance of Transcription Factors in Gastric and Colorectal Cancer Stem Cells Identification and Eradication.
Diana Pádua, Paula Figueira, +2 authors, Patrícia Mesquita.
Front Cell Dev Biol, 2020 Jul 07; 8. PMID: 32626705    Free PMC article.
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Arginine-Based Poly(I:C)-Loaded Nanocomplexes for the Polarization of Macrophages Toward M1-Antitumoral Effectors.
Tamara G Dacoba, Clément Anfray, +4 authors, José Crecente-Campo.
Front Immunol, 2020 Aug 01; 11. PMID: 32733469    Free PMC article.
Editing of Endogenous Genes in Cellular Immunotherapies.
Theodore L Roth.
Curr Hematol Malig Rep, 2020 May 18; 15(4). PMID: 32415407    Free PMC article.
Review.
Nanomedicine and Onco-Immunotherapy: From the Bench to Bedside to Biomarkers.
Vanessa Acebes-Fernández, Alicia Landeria-Viñuela, +5 authors, Manuel Fuentes.
Nanomaterials (Basel), 2020 Jul 03; 10(7). PMID: 32610601    Free PMC article.
Review.
Proof-of-Concept of Electrical Activation of Liposome Nanocarriers: From Dry to Wet Experiments.
Laura Caramazza, Martina Nardoni, +4 authors, Stefania Petralito.
Front Bioeng Biotechnol, 2020 Aug 15; 8. PMID: 32793572    Free PMC article.
Intratumoral Immunotherapy for Early-stage Solid Tumors.
Wan Xing Hong, Sarah Haebe, +4 authors, Ronald Levy.
Clin Cancer Res, 2020 Feb 20; 26(13). PMID: 32071116    Free PMC article.
Review.
Assessment of Cellular Uptake Efficiency According to Multiple Inhibitors of Fe3O4-Au Core-Shell Nanoparticles: Possibility to Control Specific Endocytosis in Colorectal Cancer Cells.
Bo Gi Park, Yu Jin Kim, +5 authors, Kyu Back Lee.
Nanoscale Res Lett, 2020 Aug 18; 15(1). PMID: 32804261    Free PMC article.
Cancer Nanomedicine Special Issue Review Anticancer Drug Delivery with Nanoparticles: Extracellular Vesicles or Synthetic Nanobeads as Therapeutic Tools for Conventional Treatment or Immunotherapy.
Maria Raffaella Zocchi, Francesca Tosetti, Roberto Benelli, Alessandro Poggi.
Cancers (Basel), 2020 Jul 17; 12(7). PMID: 32668783    Free PMC article.
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Biomaterial-Driven Immunomodulation: Cell Biology-Based Strategies to Mitigate Severe Inflammation and Sepsis.
Jackline Joy Martín Lasola, Henry Kamdem, Michael W McDaniel, Ryan M Pearson.
Front Immunol, 2020 Aug 28; 11. PMID: 32849612    Free PMC article.
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Resistance to PD-1/PD-L1 blockade cancer immunotherapy: mechanisms, predictive factors, and future perspectives.
Jin-Yu Sun, Dengke Zhang, +4 authors, Jiansong Ji.
Biomark Res, 2020 Aug 31; 8. PMID: 32864132    Free PMC article.
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Emerging Roles of 1D Vertical Nanostructures in Orchestrating Immune Cell Functions.
Yaping Chen, Ji Wang, +4 authors, Roey Elnathan.
Adv Mater, 2020 Aug 28; 32(40). PMID: 32844502    Free PMC article.
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Advanced biomaterials for cancer immunotherapy.
Fan Yang, Kun Shi, +3 authors, Zhi-Yong Qian.
Acta Pharmacol Sin, 2020 Mar 04; 41(7). PMID: 32123302    Free PMC article.
Review.
Nanomedicine-based immunotherapy for central nervous system disorders.
Sumaira Hanif, Pir Muhammad, +4 authors, Bing-Yang Shi.
Acta Pharmacol Sin, 2020 May 30; 41(7). PMID: 32467570    Free PMC article.
Review.
Engineering nanomedicines through boosting immunogenic cell death for improved cancer immunotherapy.
Jing Gao, Wei-Qi Wang, +2 authors, Hai-Jun Yu.
Acta Pharmacol Sin, 2020 Apr 23; 41(7). PMID: 32317755    Free PMC article.
Review.
Advances in synthetic lethality for cancer therapy: cellular mechanism and clinical translation.
Win Topatana, Sarun Juengpanich, +8 authors, Xiujun Cai.
J Hematol Oncol, 2020 Sep 05; 13(1). PMID: 32883316    Free PMC article.
Review.
pH-Responsive Nanoparticles for Cancer Immunotherapy: A Brief Review.
Yunfeng Yan, Hangwei Ding.
Nanomaterials (Basel), 2020 Aug 23; 10(8). PMID: 32824578    Free PMC article.
Review.
Engineered bovine serum albumin-based nanoparticles with pH-sensitivity for doxorubicin delivery and controlled release.
Zhihang Yang, Na Zhang, +3 authors, Hui Xie.
Drug Deliv, 2020 Aug 07; 27(1). PMID: 32755291    Free PMC article.
Nanoparticle-enhanced chemo-immunotherapy to trigger robust antitumor immunity.
Jingjing Liang, Huifang Wang, +17 authors, Jihong Sun.
Sci Adv, 2020 Sep 15; 6(35). PMID: 32923651    Free PMC article.
Disorder of Coagulation-Fibrinolysis System: An Emerging Toxicity of Anti-PD-1/PD-L1 Monoclonal Antibodies.
Ryo Sato, Kosuke Imamura, +13 authors, Takuro Sakagami.
J Clin Med, 2019 May 31; 8(6). PMID: 31146442    Free PMC article.
Chemically Programmed Vaccines: Iron Catalysis in Nanoparticles Enhances Combination Immunotherapy and Immunotherapy-Promoted Tumor Ferroptosis.
Ane Ruiz-de-Angulo, Marc Bilbao-Asensio, +7 authors, Juan C Mareque-Rivas.
iScience, 2020 Sep 13; 23(9). PMID: 32919370    Free PMC article.
Cancer Stem Cells in Thyroid Tumors: From the Origin to Metastasis.
Veronica Veschi, Francesco Verona, +8 authors, Matilde Todaro.
Front Endocrinol (Lausanne), 2020 Sep 29; 11. PMID: 32982967    Free PMC article.
Review.
An implantable blood clot-based immune niche for enhanced cancer vaccination.
Qin Fan, Qingle Ma, +7 authors, Chao Wang.
Sci Adv, 2020 Sep 27; 6(39). PMID: 32978163    Free PMC article.
Screening Cancer Immunotherapy: When Engineering Approaches Meet Artificial Intelligence.
Xingwu Zhou, Moyuan Qu, +9 authors, Ali Khademhosseini.
Adv Sci (Weinh), 2020 Oct 13; 7(19). PMID: 33042756    Free PMC article.
Review.
Biomedical Application of Reactive Oxygen Species-Responsive Nanocarriers in Cancer, Inflammation, and Neurodegenerative Diseases.
Jinggong Liu, Yongjin Li, +4 authors, Tianfeng Chen.
Front Chem, 2020 Oct 17; 8. PMID: 33062637    Free PMC article.
Review.
Emerging technologies for local cancer treatment.
Corrine Ying Xuan Chua, Jeremy Ho, +2 authors, Alessandro Grattoni.
Adv Ther (Weinh), 2020 Oct 20; 3(9). PMID: 33072860    Free PMC article.
A materials-science perspective on tackling COVID-19.
Zhongmin Tang, Na Kong, +12 authors, Wei Tao.
Nat Rev Mater, 2020 Oct 21;. PMID: 33078077    Free PMC article.
Review.
Neoadjuvant Immune-Checkpoint Blockade in Triple-Negative Breast Cancer: Current Evidence and Literature-Based Meta-Analysis of Randomized Trials.
Daniele Marinelli, Marco Mazzotta, +14 authors, Patrizia Vici.
Cancers (Basel), 2020 Sep 10; 12(9). PMID: 32899209    Free PMC article.
Application of Nanomaterials in Biomedical Imaging and Cancer Therapy.
Sarkar Siddique, James C L Chow.
Nanomaterials (Basel), 2020 Sep 03; 10(9). PMID: 32872399    Free PMC article.
Review.
Immunotherapy for Ovarian Cancer: Adjuvant, Combination, and Neoadjuvant.
Chang Yang, Bai-Rong Xia, +3 authors, Wei-Lin Jin.
Front Immunol, 2020 Oct 31; 11. PMID: 33123161    Free PMC article.
Review.
Immune checkpoint molecules in natural killer cells as potential targets for cancer immunotherapy.
Yuqing Cao, Xiaoyu Wang, +5 authors, Feng Xu.
Signal Transduct Target Ther, 2020 Oct 31; 5(1). PMID: 33122640    Free PMC article.
Review.
Endosomal Organization of CpG Constructs Correlates with Enhanced Immune Activation.
Kwahun Lee, Ziyin N Huang, Chad A Mirkin, Teri W Odom.
Nano Lett, 2020 Aug 14; 20(8). PMID: 32787186    Free PMC article.
Severe Acute Respiratory Syndrome Coronavirus-2 Spike Protein Nanogel as a Pro-Antigen Strategy with Enhanced Protective Immune Responses.
Long Chen, Bo Liu, +7 authors, Peng R Chen.
Small, 2020 Oct 28; 16(46). PMID: 33107685    Free PMC article.
Integrative Analysis of HNF1B mRNA in Human Cancers Based on Data Mining.
Chunhui Nie, Bei Wang, +2 authors, Enfan Zhang.
Int J Med Sci, 2020 Nov 12; 17(18). PMID: 33173410    Free PMC article.
Lipid-Nucleic Acid Complexes: Physicochemical Aspects and Prospects for Cancer Treatment.
Ricardo Gaspar, Filipe Coelho, Bruno F B Silva.
Molecules, 2020 Nov 01; 25(21). PMID: 33126767    Free PMC article.
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Microneedles Drug Delivery Systems for Treatment of Cancer: A Recent Update.
Aravindram Attiguppe Seetharam, Hani Choudhry, +7 authors, Afrasim Moin.
Pharmaceutics, 2020 Nov 21; 12(11). PMID: 33212921    Free PMC article.
Review.
Bioengineering of nano metal-organic frameworks for cancer immunotherapy.
Gaowei Chong, Jie Zang, +4 authors, Yongyong Li.
Nano Res, 2020 Dec 01;. PMID: 33250971    Free PMC article.
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Advances in engineering local drug delivery systems for cancer immunotherapy.
Peter Abdou, Zejun Wang, +4 authors, Zhen Gu.
Wiley Interdiscip Rev Nanomed Nanobiotechnol, 2020 Apr 08; 12(5). PMID: 32255276    Free PMC article.
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Proton-driven transformable nanovaccine for cancer immunotherapy.
Ningqiang Gong, Yuxuan Zhang, +17 authors, Xing-Jie Liang.
Nat Nanotechnol, 2020 Oct 28; 15(12). PMID: 33106640    Free PMC article.
Inhibition of the CCL2 receptor, CCR2, enhances tumor response to immune checkpoint therapy.
Megan M Tu, Hany A Abdel-Hafiz, +10 authors, Dan Theodorescu.
Commun Biol, 2020 Nov 29; 3(1). PMID: 33247183    Free PMC article.
Engineering precision nanoparticles for drug delivery.
Michael J Mitchell, Margaret M Billingsley, +3 authors, Robert Langer.
Nat Rev Drug Discov, 2020 Dec 06; 20(2). PMID: 33277608    Free PMC article.
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Cancer Vaccines: Toward the Next Breakthrough in Cancer Immunotherapy.
Yuka Igarashi, Tetsuro Sasada.
J Immunol Res, 2020 Dec 08; 2020. PMID: 33282961    Free PMC article.
Review.
Circ0120816 acts as an oncogene of esophageal squamous cell carcinoma by inhibiting miR-1305 and releasing TXNRD1.
Xiaoyong Li, Laichun Song, +3 authors, Ming Xu.
Cancer Cell Int, 2020 Dec 10; 20(1). PMID: 33292234    Free PMC article.
Host Immune Response Triggered by Graphene Quantum-Dot-Mediated Photodynamic Therapy for Oral Squamous Cell Carcinoma.
Xiliu Zhang, Hongyu Li, +7 authors, Dongsheng Yu.
Int J Nanomedicine, 2020 Dec 10; 15. PMID: 33293811    Free PMC article.
Engineering Prodrug Nanomedicine for Cancer Immunotherapy.
Bin Yang, Jing Gao, +2 authors, Haijun Yu.
Adv Sci (Weinh), 2020 Dec 12; 7(23). PMID: 33304763    Free PMC article.
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Improving cancer immunotherapy using nanomedicines: progress, opportunities and challenges.
John D Martin, Horacio Cabral, Triantafyllos Stylianopoulos, Rakesh K Jain.
Nat Rev Clin Oncol, 2020 Feb 09; 17(4). PMID: 32034288
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Competitive glucose metabolism as a target to boost bladder cancer immunotherapy.
Julieta Afonso, Lúcio L Santos, Adhemar Longatto-Filho, Fátima Baltazar.
Nat Rev Urol, 2020 Jan 19; 17(2). PMID: 31953517
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Lymphatic immunomodulation using engineered drug delivery systems for cancer immunotherapy.
Margaret P Manspeaker, Susan N Thomas.
Adv Drug Deliv Rev, 2020 Oct 16; 160. PMID: 33058931    Free PMC article.
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Integrating Biomaterials and Immunology to Improve Vaccines Against Infectious Diseases.
Lampouguin Yenkoidiok-Douti, Christopher M Jewell.
ACS Biomater Sci Eng, 2020 Dec 15; 6(2). PMID: 33313391    Free PMC article.
Nanoparticle Formulations of Poly (ADP-ribose) Polymerase Inhibitors for Cancer Therapy.
Bijay Singh, Shicheng Yang, Apurva Krishna, Srinivas Sridhar.
Front Chem, 2020 Dec 18; 8. PMID: 33330383    Free PMC article.
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Implantable and Injectable Biomaterial Scaffolds for Cancer Immunotherapy.
Jie Li, Yiqian Luo, +3 authors, Changfeng Fu.
Front Bioeng Biotechnol, 2020 Dec 18; 8. PMID: 33330440    Free PMC article.
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Size-transformable antigen-presenting cell-mimicking nanovesicles potentiate effective cancer immunotherapy.
Weijing Yang, Hongzhang Deng, +9 authors, Xiaoyuan Chen.
Sci Adv, 2020 Dec 15; 6(50). PMID: 33310853    Free PMC article.
Strategies for Cancer Immunotherapy Using Induced Pluripotency Stem Cells-Based Vaccines.
Bruno Bernardes de Jesus, Bruno Miguel Neves, Manuela Ferreira, Sandrina Nóbrega-Pereira.
Cancers (Basel), 2020 Dec 04; 12(12). PMID: 33266109    Free PMC article.
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Precision Tools in Immuno-Oncology: Synthetic Gene Circuits for Cancer Immunotherapy.
Giuliano Bonfá, Juan Blazquez-Roman, Rita Tarnai, Velia Siciliano.
Vaccines (Basel), 2020 Dec 09; 8(4). PMID: 33287392    Free PMC article.
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Cancer Immunotherapy and Application of Nanoparticles in Cancers Immunotherapy as the Delivery of Immunotherapeutic Agents and as the Immunomodulators.
Tilahun Ayane Debele, Cheng-Fa Yeh, Wen-Pin Su.
Cancers (Basel), 2020 Dec 19; 12(12). PMID: 33333816    Free PMC article.
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MRI-traceable theranostic nanoparticles for targeted cancer treatment.
Tareq Anani, Shiva Rahmati, Nayer Sultana, Allan E David.
Theranostics, 2021 Jan 05; 11(2). PMID: 33391494    Free PMC article.
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Anti-Cancer Nanomedicines: A Revolution of Tumor Immunotherapy.
Wei Li, Anghui Peng, +4 authors, Min Cui.
Front Immunol, 2021 Jan 08; 11. PMID: 33408716    Free PMC article.
Review.
Transdermal Delivery Systems for Biomolecules.
Ma Concepción Peña-Juárez, Omar Rodrigo Guadarrama-Escobar, José Juan Escobar-Chávez.
J Pharm Innov, 2021 Jan 12;. PMID: 33425065    Free PMC article.
Review.
BIRC5 is a prognostic biomarker associated with tumor immune cell infiltration.
Linlong Xu, Wenpeng Yu, Han Xiao, Kang Lin.
Sci Rep, 2021 Jan 13; 11(1). PMID: 33431968    Free PMC article.
Therapeutic Approaches for Metastases from Colorectal Cancer and Pancreatic Ductal Carcinoma.
Adriana G Quiroz-Reyes, Jose F Islas, +2 authors, Elsa N Garza-Treviño.
Pharmaceutics, 2021 Jan 21; 13(1). PMID: 33466892    Free PMC article.
Review.
Advances in Bio-Based Polymers for Colorectal CancerTreatment: Hydrogels and Nanoplatforms.
Anna Maspes, Fabio Pizzetti, +3 authors, Filippo Rossi.
Gels, 2021 Jan 15; 7(1). PMID: 33440908    Free PMC article.
Review.
Activatable polymer nanoagonist for second near-infrared photothermal immunotherapy of cancer.
Yuyan Jiang, Jiaguo Huang, Cheng Xu, Kanyi Pu.
Nat Commun, 2021 Feb 04; 12(1). PMID: 33531498    Free PMC article.
Biohybrid Nanosystems for Cancer Treatment: Merging the Best of Two Worlds.
Flavia Fontana, Raquél Bartolo, Hélder A Santos.
Adv Exp Med Biol, 2021 Feb 06; 1295. PMID: 33543459
Delivery technologies for in utero gene therapy.
Rohan Palanki, William H Peranteau, Michael J Mitchell.
Adv Drug Deliv Rev, 2020 Nov 13; 169. PMID: 33181188    Free PMC article.
Review.
Ionizable lipid nanoparticles for in utero mRNA delivery.
Rachel S Riley, Meghana V Kashyap, +10 authors, Michael J Mitchell.
Sci Adv, 2021 Feb 02; 7(3). PMID: 33523869    Free PMC article.
Peptide functionalized liposomes for receptor targeted cancer therapy.
Matthew R Aronson, Scott H Medina, Michael J Mitchell.
APL Bioeng, 2021 Feb 04; 5(1). PMID: 33532673    Free PMC article.
Review.
Nanomedicine-based cancer immunotherapy: recent trends and future perspectives.
Vinoth-Kumar Lakshmanan, Shlok Jindal, +8 authors, Salem Chouaib.
Cancer Gene Ther, 2021 Feb 10;. PMID: 33558704
Review.
DNA scaffolds enable efficient and tunable functionalization of biomaterials for immune cell modulation.
Xiao Huang, Jasper Z Williams, +10 authors, Tejal A Desai.
Nat Nanotechnol, 2020 Dec 16; 16(2). PMID: 33318641    Free PMC article.
Self-Assembly as a Molecular Strategy to Improve Immunotherapy.
Eugene Froimchuk, Sean T Carey, Camilla Edwards, Christopher M Jewell.
Acc Chem Res, 2020 Oct 20; 53(11). PMID: 33074649    Free PMC article.
Overcoming biological barriers to improve solid tumor immunotherapy.
Anvay Ukidve, Katharina Cu, +2 authors, Samir Mitragotri.
Drug Deliv Transl Res, 2021 Feb 22;. PMID: 33611770
Tumor-associated macrophage polarization promotes the progression of esophageal carcinoma.
Xin Yuan, Ya Li, +11 authors, Jian Ming Hu.
Aging (Albany NY), 2020 Dec 17; 13(2). PMID: 33323552    Free PMC article.
Methotrexate enhances antigen presentation and maturation of tumour antigen-loaded dendritic cells through NLRP3 inflammasome activation: a strategy for dendritic cell-based cancer vaccine.
Gao-Na Shi, Min Hu, +5 authors, Tiantai Zhang.
Ther Adv Med Oncol, 2021 Feb 23; 13. PMID: 33613696    Free PMC article.
A biomimetic antitumor nanovaccine based on biocompatible calcium pyrophosphate and tumor cell membrane antigens.
Minghui Li, Mengmeng Qin, +7 authors, Qiang Zhang.
Asian J Pharm Sci, 2021 Feb 23; 16(1). PMID: 33613733    Free PMC article.
Testosterone deficiency in men receiving immunotherapy for malignant melanoma.
Madeline Peters, Amy Pearlman, +2 authors, Varun Monga.
Oncotarget, 2021 Feb 23; 12(3). PMID: 33613847    Free PMC article.
Microspheres Encapsulating Immunotherapy Agents Target the Tumor-Draining Lymph Node in Pancreatic Ductal Adenocarcinoma.
Booyeon J Han, Joseph D Murphy, +10 authors, Scott A Gerber.
Immunol Invest, 2020 Jun 06; 49(7). PMID: 32498585    Free PMC article.
CD155-Prognostic and Immunotherapeutic Implications Based on Multiple Analyses of Databases Across 33 Human Cancers.
Hongpan Zhang, Zhihao Yang, +2 authors, BangXian Tan.
Technol Cancer Res Treat, 2021 Feb 13; 20. PMID: 33576304    Free PMC article.
Application of Bionanomaterials in Tumor Immune Microenvironment Therapy.
Jiawei Wang, Yan Bao, Yandan Yao.
J Immunol Res, 2021 Feb 26; 2021. PMID: 33628850    Free PMC article.
Review.
Recent advances in materials science: a reinforced approach toward challenges against COVID-19.
Abhinav Saxena, Deepak Khare, +2 authors, Ashutosh Kumar Dubey.
Emergent Mater, 2021 Mar 02;. PMID: 33644691    Free PMC article.
Review.
Targeting the PD-1 Axis with Pembrolizumab for Recurrent or Metastatic Cancer of the Uterine Cervix: A Brief Update.
Yannick Verhoeven, Delphine Quatannens, +5 authors, Peter A van Dam.
Int J Mol Sci, 2021 Mar 07; 22(4). PMID: 33670397    Free PMC article.
Review.
Theranostic Tripartite Cancer Terminator Virus for Cancer Therapy and Imaging.
Praveen Bhoopathi, Anjan K Pradhan, +3 authors, Paul B Fisher.
Cancers (Basel), 2021 Mar 07; 13(4). PMID: 33670594    Free PMC article.
Summary From the First Kidney Cancer Research Summit, September 12-13, 2019: A Focus on Translational Research.
Toni K Choueiri, Michael B Atkins, +17 authors, Hans J Hammers.
J Natl Cancer Inst, 2020 May 03; 113(3). PMID: 32359162    Free PMC article.
The Identification and Validation of a Robust Immune-Associated Gene Signature in Cutaneous Melanoma.
Le-Bin Song, Jiao-Chen Luan, +5 authors, Yan Lu.
J Immunol Res, 2021 Mar 11; 2021. PMID: 33688507    Free PMC article.
TIM-3 as a Prognostic Marker and a Potential Immunotherapy Target in Human Malignant Tumors: A Meta-Analysis and Bioinformatics Validation.
Kui Zang, Liangliang Hui, +3 authors, Bin Yao.
Front Oncol, 2021 Mar 12; 11. PMID: 33692946    Free PMC article.
Systematic Review.
Enhancing delivery of small molecule and cell-based therapies for ovarian cancer using advanced delivery strategies.
Joanne O'Dwyer, Roisin E O'Cearbhaill, +4 authors, Eimear B Dolan.
Adv Ther (Weinh), 2021 Mar 13; 3(11). PMID: 33709016    Free PMC article.
Tumor-derived ILT4 induces T cell senescence and suppresses tumor immunity.
Aiqin Gao, Xia Liu, +7 authors, Guangyong Peng.
J Immunother Cancer, 2021 Mar 04; 9(3). PMID: 33653799    Free PMC article.
CRISPR/Cas-Dependent and Nuclease-Free In Vivo Therapeutic Gene Editing.
Ishani Dasgupta, Terence R Flotte, Allison M Keeler.
Hum Gene Ther, 2021 Mar 23; 32(5-6). PMID: 33750221    Free PMC article.
Cyclophosphamide loaded thermo-responsive hydrogel system synergize with a hydrogel cancer vaccine to amplify cancer immunotherapy in a prime-boost manner.
Fan Yang, Kun Shi, +7 authors, Zhiyong Qian.
Bioact Mater, 2021 Mar 30; 6(10). PMID: 33778186    Free PMC article.
Enhancing Cancer Immunotherapy Treatment Goals by Using Nanoparticle Delivery System.
Tobias Achu Muluh, Zhuo Chen, +4 authors, JingBo Wu.
Int J Nanomedicine, 2021 Apr 02; 16. PMID: 33790556    Free PMC article.
Review.
The evolution of commercial drug delivery technologies.
Ava M Vargason, Aaron C Anselmo, Samir Mitragotri.
Nat Biomed Eng, 2021 Apr 03;. PMID: 33795852
Review.
Integrated bioinformatic analysis of HNF1A in human cancers.
Enfan Zhang, Xi Huang, Jingsong He.
J Int Med Res, 2021 Mar 24; 49(3). PMID: 33752475    Free PMC article.
Polysaccharide-based nanomedicines for cancer immunotherapy: A review.
Yujun Zeng, Yufan Xiang, +6 authors, Kui Luo.
Bioact Mater, 2021 Apr 06; 6(10). PMID: 33817416    Free PMC article.
Review.
Current status and future perspectives of immunotherapy in bladder cancer treatment.
Zhangsong Wu, Jinjian Liu, Ruixiang Dai, Song Wu.
Sci China Life Sci, 2020 Sep 15; 64(4). PMID: 32926318
Review.
Clinical Potential of Kinase Inhibitors in Combination with Immune Checkpoint Inhibitors for the Treatment of Solid Tumors.
Ryuhjin Ahn, Josie Ursini-Siegel.
Int J Mol Sci, 2021 Apr 04; 22(5). PMID: 33807608    Free PMC article.
Review.
A Comprehensive Investigation to Reveal the Relationship Between Plasmacytoid Dendritic Cells and Breast Cancer by Multiomics Data Analysis.
Saisai Tian, Li Yan, +4 authors, Weidong Zhang.
Front Cell Dev Biol, 2021 Apr 20; 9. PMID: 33869191    Free PMC article.
Delivery technologies to engineer natural killer cells for cancer immunotherapy.
Rakan El-Mayta, Zijing Zhang, Alex G Hamilton, Michael J Mitchell.
Cancer Gene Ther, 2021 Apr 24;. PMID: 33888870
Review.