FcγR-Binding Is an Important Functional Attribute for Immune Checkpoint Antibodies in Cancer Immunotherapy

Xin Chen ¹, Xiaomin Song ¹, Kang Li ¹, Tong Zhang ¹

Affiliations

¹ BeiGene (Beijing) Co., Ltd., Beijing, China.

PMID: 30863404
154 References
45 citations

Abstract

T cells play critical roles in anti-tumor immunity. Up-regulation of immune checkpoint molecules (PD-1, PD-L1, CTLA-4, TIM-3, Lag-3, TIGIT, CD73, VISTA, B7-H3) in the tumor microenvironment is an important mechanism that restrains effector T cells from the anti-tumor activity. To date, immune checkpoint antibodies have demonstrated significant clinical benefits for cancer patients treated with mono- or combination immunotherapies. However, many tumors do not respond to the treatment well, and merely blocking the immune suppression pathways by checkpoint-regulatory antibodies may not render optimal tumor growth inhibition. Binding of the antibody Fc-hinge region to Fc gamma receptors (FcγRs) has been shown to exert a profound impact on antibody function and in vivo efficacy. Investigation of immune checkpoint antibodies regarding their effector functions and impact on therapeutic efficacy has gained more attention in recent years. In this review, we discuss Fc variants of antibodies against immune checkpoint targets and the potential mechanisms of how FcγR-binding could influence the anti-tumor activity of these antibodies.

Keywords: FcγR; IgG isotype; antibody therapy; cancer immunotherapy; checkpoint blockade.

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References
Development of lupus-like autoimmune diseases by disruption of the PD-1 gene encoding an ITIM motif-carrying immunoreceptor. H Nishimura, M Nose, +2 authors, H Hiai, N Minato, T Honjo. less Immunity, 1999 Sep 15; 11(2). PMID: 10485649 Highly Cited.
B7-H1, a third member of the B7 family, co-stimulates T-cell proliferation and interleukin-10 secretion. H Dong, G Zhu, K Tamada, L Chen. Nat Med, 1999 Dec 02; 5(12). PMID: 10581077 Highly Cited.
In vitro characterization of five humanized OKT3 effector function variant antibodies. D Xu, M L Alegre, +9 authors, R A Zivin. less Cell Immunol, 2000 Mar 16; 200(1). PMID: 10716879
Inhibitory Fc receptors modulate in vivo cytotoxicity against tumor targets. R A Clynes, T L Towers, L G Presta, J V Ravetch. Nat Med, 2000 Mar 31; 6(4). PMID: 10742152 Highly Cited.
The IgG Fc contains distinct Fc receptor (FcR) binding sites: the leukocyte receptors Fc gamma RI and Fc gamma RIIa bind to a region in the Fc distinct from that recognized by neonatal FcR and protein A. B D Wines, M S Powell, +2 authors, P W Parren, N Barnes, P M Hogarth. less J Immunol, 2000 May 09; 164(10). PMID: 10799893
High resolution mapping of the binding site on human IgG1 for Fc gamma RI, Fc gamma RII, Fc gamma RIII, and FcRn and design of IgG1 variants with improved binding to the Fc gamma R. R L Shields, A K Namenuk, +9 authors, L G Presta. less J Biol Chem, 2000 Nov 30; 276(9). PMID: 11096108 Highly Cited.
PD-L2 is a second ligand for PD-1 and inhibits T cell activation. Y Latchman, C R Wood, +18 authors, G J Freeman. less Nat Immunol, 2001 Feb 27; 2(3). PMID: 11224527 Highly Cited.
B7-H3: a costimulatory molecule for T cell activation and IFN-gamma production. A I Chapoval, J Ni, +8 authors, L Chen. less Nat Immunol, 2001 Feb 27; 2(3). PMID: 11224528 Highly Cited.
IgG4 breaking the rules. Rob C Aalberse, Janine Schuurman. Immunology, 2002 Feb 19; 105(1). PMID: 11849310 Free PMC article. Highly Cited. Review.
FcgammaRI (CD64) contributes substantially to severity of arthritis, hypersensitivity responses, and protection from bacterial infection. A Ioan-Facsinay, S J de Kimpe, +18 authors, J S Verbeek. less Immunity, 2002 Mar 26; 16(3). PMID: 11911824
B7 family molecules: novel immunomodulators at the maternal-fetal interface. M G Petroff, L Chen, T A Phillips, J S Hunt. Placenta, 2002 Apr 30; 23 Suppl A. PMID: 11978065 Review.
Characterization of mouse and human B7-H3 genes. Mingyi Sun, Sabrina Richards, +3 authors, Chen Dong. less J Immunol, 2002 Jun 11; 168(12). PMID: 12055244
Tumor-associated B7-H1 promotes T-cell apoptosis: a potential mechanism of immune evasion. Haidong Dong, Scott E Strome, +10 authors, Lieping Chen. less Nat Med, 2002 Jul 02; 8(8). PMID: 12091876 Highly Cited.
Identification of PVR (CD155) and Nectin-2 (CD112) as cell surface ligands for the human DNAM-1 (CD226) activating molecule. Cristina Bottino, Roberta Castriconi, +11 authors, Alessandro Moretta. less J Exp Med, 2003 Aug 13; 198(4). PMID: 12913096 Free PMC article. Highly Cited.
Induced expression of PD-1, a novel member of the immunoglobulin gene superfamily, upon programmed cell death. Y Ishida, Y Agata, K Shibahara, T Honjo. EMBO J, 1992 Nov 01; 11(11). PMID: 1396582 Free PMC article. Highly Cited.
Interaction of Tim-3 and Tim-3 ligand regulates T helper type 1 responses and induction of peripheral tolerance. Catherine A Sabatos, Sumone Chakravarti, +7 authors, Vijay K Kuchroo. less Nat Immunol, 2003 Oct 14; 4(11). PMID: 14556006 Highly Cited.
Lymphocyte activation gene-3 (CD223) regulates the size of the expanding T cell population following antigen activation in vivo. Creg J Workman, Linda S Cauley, +3 authors, Dario A A Vignali. less J Immunol, 2004 Apr 22; 172(9). PMID: 15100286
Murine B7-H3 is a negative regulator of T cells. Durbaka V R Prasad, Thang Nguyen, +4 authors, Chen Dong. less J Immunol, 2004 Aug 06; 173(4). PMID: 15294965
B7-1 and B7-2 selectively recruit CTLA-4 and CD28 to the immunological synapse. Tsvetelina Pentcheva-Hoang, Jackson G Egen, Kathleen Wojnoonski, James P Allison. Immunity, 2004 Sep 11; 21(3). PMID: 15357951 Highly Cited.
Role of LAG-3 in regulatory T cells. Ching-Tai Huang, Creg J Workman, +11 authors, Dario A A Vignali. less Immunity, 2004 Oct 16; 21(4). PMID: 15485628 Highly Cited.
A theoretical framework for quantitative analysis of the molecular basis of costimulation. Andreas Jansson, Eleanor Barnes, +4 authors, Patric Nilsson. less J Immunol, 2005 Jul 22; 175(3). PMID: 16034096
FcgammaRIV: a novel FcR with distinct IgG subclass specificity. Falk Nimmerjahn, Pierre Bruhns, Ken Horiuchi, Jeffrey V Ravetch. Immunity, 2005 Jul 26; 23(1). PMID: 16039578 Highly Cited.
FcgammaRIIB Ile232Thr transmembrane polymorphism associated with human systemic lupus erythematosus decreases affinity to lipid rafts and attenuates inhibitory effects on B cell receptor signaling. Hajime Kono, Chieko Kyogoku, +5 authors, Zen-Ichiro Honda. less Hum Mol Genet, 2005 Aug 24; 14(19). PMID: 16115811
A molecular perspective of CTLA-4 function. Wendy A Teft, Mark G Kirchhof, Joaquín Madrenas. Annu Rev Immunol, 2006 Mar 23; 24. PMID: 16551244 Highly Cited. Review.
B7-H3 and B7-H4 expression in non-small-cell lung cancer. Yuping Sun, Yunshan Wang, +4 authors, Xiongbiao Wang. less Lung Cancer, 2006 Jun 20; 53(2). PMID: 16782226 Highly Cited.
LAG-3, a novel lymphocyte activation gene closely related to CD4. F Triebel, S Jitsukawa, +4 authors, T Hercend. less J Exp Med, 1990 May 01; 171(5). PMID: 1692078 Free PMC article. Highly Cited.
TIM-3 in autoimmunity. Ana C Anderson, David E Anderson. Curr Opin Immunol, 2006 Oct 03; 18(6). PMID: 17011764 Review.
B7-H1-induced apoptosis as a mechanism of immune privilege of corneal allografts. Junko Hori, Mingcong Wang, +6 authors, Miyuki Azuma. less J Immunol, 2006 Oct 24; 177(9). PMID: 17056517
Systemic lupus erythematosus-associated defects in the inhibitory receptor FcgammaRIIb reduce susceptibility to malaria. Menna R Clatworthy, Lisa Willcocks, +6 authors, Kenneth G C Smith. less Proc Natl Acad Sci U S A, 2007 Apr 17; 104(17). PMID: 17435165 Free PMC article.
B7-H3 ligand expression by prostate cancer: a novel marker of prognosis and potential target for therapy. Timothy J Roth, Yuri Sheinin, +10 authors, Eugene D Kwon. less Cancer Res, 2007 Aug 10; 67(16). PMID: 17686830
LAG-3 regulates CD8+ T cell accumulation and effector function in murine self- and tumor-tolerance systems. Joseph F Grosso, Cristin C Kelleher, +10 authors, Charles G Drake. less J Clin Invest, 2007 Oct 13; 117(11). PMID: 17932562 Free PMC article. Highly Cited.
B7-H3 and B7x are highly expressed in human prostate cancer and associated with disease spread and poor outcome. Xingxing Zang, R Houston Thompson, +6 authors, James P Allison. less Proc Natl Acad Sci U S A, 2007 Nov 29; 104(49). PMID: 18042703 Free PMC article. Highly Cited.
Fcgamma receptors as regulators of immune responses. Falk Nimmerjahn, Jeffrey V Ravetch. Nat Rev Immunol, 2007 Dec 08; 8(1). PMID: 18064051 Highly Cited. Review.
PD-1 and its ligands in tolerance and immunity. Mary E Keir, Manish J Butte, Gordon J Freeman, Arlene H Sharpe. Annu Rev Immunol, 2008 Jan 05; 26. PMID: 18173375 Highly Cited. Review.
A single amino acid distinguishes the high-responder from the low-responder form of Fc receptor II on human monocytes. M R Clark, S G Stuart, +2 authors, R P Kimberly, P A Ory, I M Goldstein. less Eur J Immunol, 1991 Aug 01; 21(8). PMID: 1831131
Human IgG2 antibodies display disulfide-mediated structural isoforms. Jette Wypych, Ming Li, +11 authors, Alain Balland. less J Biol Chem, 2008 Mar 15; 283(23). PMID: 18339624 Free PMC article.
Structural and functional characterization of disulfide isoforms of the human IgG2 subclass. Thomas M Dillon, Margaret Speed Ricci, +11 authors, Pavel V Bondarenko. less J Biol Chem, 2008 Mar 15; 283(23). PMID: 18339626 Free PMC article.
Structural characterization of a human Fc fragment engineered for lack of effector functions. Vaheh Oganesyan, Changshou Gao, +2 authors, Lena Shirinian, Herren Wu, William F Dall'Acqua. less Acta Crystallogr D Biol Crystallogr, 2008 Jun 19; 64(Pt 6). PMID: 18560159 Free PMC article.
Tumor cell and tumor vasculature expression of B7-H3 predict survival in clear cell renal cell carcinoma. Paul L Crispen, Yuri Sheinin, +9 authors, Eugene D Kwon. less Clin Cancer Res, 2008 Aug 13; 14(16). PMID: 18694993 Free PMC article.
Human IgG2 antibody disulfide rearrangement in vivo. Y Diana Liu, Xiaoyu Chen, +3 authors, Gregory C Flynn. less J Biol Chem, 2008 Aug 21; 283(43). PMID: 18713741 Free PMC article.
CTLA-4 blockade increases IFNgamma-producing CD4+ICOShi cells to shift the ratio of effector to regulatory T cells in cancer patients. Chrysoula I Liakou, Ashish Kamat, +5 authors, Padmanee Sharma. less Proc Natl Acad Sci U S A, 2008 Sep 27; 105(39). PMID: 18818309 Free PMC article. Highly Cited.
CTLA-4 control over Foxp3+ regulatory T cell function. Kajsa Wing, Yasushi Onishi, +5 authors, Shimon Sakaguchi. less Science, 2008 Oct 11; 322(5899). PMID: 18845758 Highly Cited.
Crucial role of aspartic acid at position 265 in the CH2 domain for murine IgG2a and IgG2b Fc-associated effector functions. Lucie Baudino, Yasuro Shinohara, +7 authors, Shozo Izui. less J Immunol, 2008 Oct 23; 181(9). PMID: 18941257
The surface protein TIGIT suppresses T cell activation by promoting the generation of mature immunoregulatory dendritic cells. Xin Yu, Kristin Harden, +9 authors, Jane L Grogan. less Nat Immunol, 2008 Nov 18; 10(1). PMID: 19011627 Highly Cited.
Specificity and affinity of human Fcgamma receptors and their polymorphic variants for human IgG subclasses. Pierre Bruhns, Bruno Iannascoli, +4 authors, Marc Daëron. less Blood, 2008 Nov 20; 113(16). PMID: 19018092 Highly Cited.
A novel molecular interaction for the adhesion of follicular CD4 T cells to follicular DC. Kent S Boles, William Vermi, +5 authors, Marco Colonna. less Eur J Immunol, 2009 Feb 07; 39(3). PMID: 19197944 Free PMC article.
Expression of adhesion molecules and ligands for activating and costimulatory receptors involved in cell-mediated cytotoxicity in a large panel of human melanoma cell lines. Javier G Casado, Graham Pawelec, +6 authors, Raquel Tarazona. less Cancer Immunol Immunother, 2009 Mar 05; 58(9). PMID: 19259667 Review.
Diagnosis value of serum B7-H3 expression in non-small cell lung cancer. Guangbo Zhang, Yuehua Xu, +4 authors, Xueguang Zhang. less Lung Cancer, 2009 Mar 10; 66(2). PMID: 19269710
PD-1 on dendritic cells impedes innate immunity against bacterial infection. Sheng Yao, Shengdian Wang, +9 authors, Lieping Chen. less Blood, 2009 Apr 03; 113(23). PMID: 19339692 Free PMC article.
Tumor antigen-specific CD8 T cells infiltrating the tumor express high levels of PD-1 and are functionally impaired. Mojgan Ahmadzadeh, Laura A Johnson, +4 authors, Steven A Rosenberg. less Blood, 2009 May 09; 114(8). PMID: 19423728 Free PMC article. Highly Cited.
Negative immune regulator Tim-3 is overexpressed on T cells in hepatitis C virus infection and its blockade rescues dysfunctional CD4+ and CD8+ T cells. Lucy Golden-Mason, Brent E Palmer, +7 authors, Hugo R Rosen. less J Virol, 2009 Jul 10; 83(18). PMID: 19587053 Free PMC article. Highly Cited.
Therapeutic IgG4 antibodies engage in Fab-arm exchange with endogenous human IgG4 in vivo. Aran F Labrijn, Antonio Ortiz Buijsse, +9 authors, Paul W H I Parren. less Nat Biotechnol, 2009 Jul 22; 27(8). PMID: 19620983
The interaction of TIGIT with PVR and PVRL2 inhibits human NK cell cytotoxicity. Noa Stanietsky, Hrvoje Simic, +11 authors, Ofer Mandelboim. less Proc Natl Acad Sci U S A, 2009 Oct 10; 106(42). PMID: 19815499 Free PMC article. Highly Cited.
IgG2m4, an engineered antibody isotype with reduced Fc function. Zhiqiang An, Gail Forrest, +13 authors, William Strohl. less MAbs, 2010 Jan 16; 1(6). PMID: 20073128 Free PMC article.
Programmed death-1-induced interleukin-10 production by monocytes impairs CD4+ T cell activation during HIV infection. Elias A Said, Franck P Dupuy, +16 authors, Rafick-Pierre Sekaly. less Nat Med, 2010 Mar 09; 16(4). PMID: 20208540 Free PMC article. Highly Cited.
Tumor-infiltrating NY-ESO-1-specific CD8+ T cells are negatively regulated by LAG-3 and PD-1 in human ovarian cancer. Junko Matsuzaki, Sacha Gnjatic, +9 authors, Kunle Odunsi. less Proc Natl Acad Sci U S A, 2010 Apr 14; 107(17). PMID: 20385810 Free PMC article. Highly Cited.
Therapeutic antibodies for autoimmunity and inflammation. Andrew C Chan, Paul J Carter. Nat Rev Immunol, 2010 Apr 24; 10(5). PMID: 20414204 Highly Cited. Review.
FcgammaRIIB in autoimmunity and infection: evolutionary and therapeutic implications. Kenneth G C Smith, Menna R Clatworthy. Nat Rev Immunol, 2010 Apr 24; 10(5). PMID: 20414206 Free PMC article. Highly Cited. Review.
Tumor associated endothelial expression of B7-H3 predicts survival in ovarian carcinomas. Xingxing Zang, Peggy S Sullivan, +10 authors, James P Allison. less Mod Pathol, 2010 May 25; 23(8). PMID: 20495537 Free PMC article.
Upregulation of Tim-3 and PD-1 expression is associated with tumor antigen-specific CD8+ T cell dysfunction in melanoma patients. Julien Fourcade, Zhaojun Sun, +6 authors, Hassane M Zarour. less J Exp Med, 2010 Sep 08; 207(10). PMID: 20819923 Free PMC article. Highly Cited.
Targeting Tim-3 and PD-1 pathways to reverse T cell exhaustion and restore anti-tumor immunity. Kaori Sakuishi, Lionel Apetoh, +3 authors, Ana C Anderson. less J Exp Med, 2010 Sep 08; 207(10). PMID: 20819927 Free PMC article. Highly Cited.
FcγRIV deletion reveals its central role for IgG2a and IgG2b activity in vivo. Falk Nimmerjahn, Anja Lux, +5 authors, Jeffrey V Ravetch. less Proc Natl Acad Sci U S A, 2010 Oct 27; 107(45). PMID: 20974962 Free PMC article.
PD-1 and LAG-3 inhibitory co-receptors act synergistically to prevent autoimmunity in mice. Taku Okazaki, Il-mi Okazaki, +9 authors, Tasuku Honjo. less J Exp Med, 2011 Feb 09; 208(2). PMID: 21300912 Free PMC article.
Vstm3 is a member of the CD28 family and an important modulator of T-cell function. Steven D Levin, David W Taft, +21 authors, Katherine E Lewis. less Eur J Immunol, 2011 Mar 19; 41(4). PMID: 21416464 Free PMC article.
Characterization of soluble vs membrane-bound human placental 5'-nucleotidase. M R Klemens, W R Sherman, +3 authors, N J Holmberg, J M Ruedi, M G Low, L F Thompson. less Biochem Biophys Res Commun, 1990 Nov 15; 172(3). PMID: 2173922
Immune inhibitory molecules LAG-3 and PD-1 synergistically regulate T-cell function to promote tumoral immune escape. Seng-Ryong Woo, Meghan E Turnis, +18 authors, Dario A A Vignali. less Cancer Res, 2011 Dec 22; 72(4). PMID: 22186141 Free PMC article. Highly Cited.
High expression of CD73 as a poor prognostic biomarker in human colorectal cancer. Xian-Rui Wu, Xiao-Sheng He, +7 authors, Ping Lan. less J Surg Oncol, 2012 Jan 31; 106(2). PMID: 22287455
Disulfide bond structures of IgG molecules: structural variations, chemical modifications and possible impacts to stability and biological function. Hongcheng Liu, Kimberly May. MAbs, 2012 Feb 14; 4(1). PMID: 22327427 Free PMC article. Highly Cited. Review.
TIM-3 expression characterizes regulatory T cells in tumor tissues and is associated with lung cancer progression. Xin Gao, Yibei Zhu, +7 authors, Binfeng Lu. less PLoS One, 2012 Mar 01; 7(2). PMID: 22363469 Free PMC article. Highly Cited.
The blockade of immune checkpoints in cancer immunotherapy. Drew M Pardoll. Nat Rev Cancer, 2012 Mar 23; 12(4). PMID: 22437870 Free PMC article. Highly Cited. Review.
Tim-3/galectin-9 signaling pathway mediates T-cell dysfunction and predicts poor prognosis in patients with hepatitis B virus-associated hepatocellular carcinoma. Hang Li, Ke Wu, +8 authors, Weiping Zou. less Hepatology, 2012 Apr 17; 56(4). PMID: 22505239 Highly Cited.
Ectopic expression of TIM-3 in lung cancers: a potential independent prognostic factor for patients with NSCLC. Xuewei Zhuang, Xiaoning Zhang, +5 authors, Chunhong Ma. less Am J Clin Pathol, 2012 May 16; 137(6). PMID: 22586058
Development of an Fc-enhanced anti-B7-H3 monoclonal antibody with potent antitumor activity. Deryk Loo, Ralph F Alderson, +21 authors, Paul A Moore. less Clin Cancer Res, 2012 May 23; 18(14). PMID: 22615450
Safety, activity, and immune correlates of anti-PD-1 antibody in cancer. Suzanne L Topalian, F Stephen Hodi, +27 authors, Mario Sznol. less N Engl J Med, 2012 Jun 05; 366(26). PMID: 22658127 Free PMC article. Highly Cited.
Apoptotic and antitumor activity of death receptor antibodies require inhibitory Fcγ receptor engagement. Fubin Li, Jeffrey V Ravetch. Proc Natl Acad Sci U S A, 2012 Jun 23; 109(27). PMID: 22723355 Free PMC article.
FcγRIIb on liver sinusoidal endothelium clears small immune complexes. Latha P Ganesan, Jonghan Kim, +5 authors, Clark L Anderson. less J Immunol, 2012 Oct 12; 189(10). PMID: 23053513 Free PMC article.
The high-affinity human IgG receptor FcγRI (CD64) promotes IgG-mediated inflammation, anaphylaxis, and antitumor immunotherapy. David A Mancardi, Marcello Albanesi, +6 authors, Pierre Bruhns. less Blood, 2013 Jan 08; 121(9). PMID: 23293080
Tim-3 expression defines regulatory T cells in human tumors. Jing Yan, Yi Zhang, +3 authors, Jing-Ping Zhang, Jing Liang, Lian Li, Limin Zheng. less PLoS One, 2013 Mar 26; 8(3). PMID: 23526963 Free PMC article.
Structure and T cell inhibition properties of B7 family member, B7-H3. Vladimir Vigdorovich, Udupi A Ramagopal, +6 authors, Steven C Almo. less Structure, 2013 Apr 16; 21(5). PMID: 23583036 Free PMC article.
CD73 promotes anthracycline resistance and poor prognosis in triple negative breast cancer. Sherene Loi, Sandra Pommey, +4 authors, John Stagg. less Proc Natl Acad Sci U S A, 2013 Jun 19; 110(27). PMID: 23776241 Free PMC article. Highly Cited.
Fc-dependent depletion of tumor-infiltrating regulatory T cells co-defines the efficacy of anti-CTLA-4 therapy against melanoma. Tyler R Simpson, Fubin Li, +11 authors, Sergio A Quezada. less J Exp Med, 2013 Jul 31; 210(9). PMID: 23897981 Free PMC article. Highly Cited.
Activating Fc γ receptors contribute to the antitumor activities of immunoregulatory receptor-targeting antibodies. Yannick Bulliard, Rose Jolicoeur, +6 authors, Jennifer L Brogdon. less J Exp Med, 2013 Jul 31; 210(9). PMID: 23897982 Free PMC article. Highly Cited.
Antitumor activities of agonistic anti-TNFR antibodies require differential FcγRIIB coengagement in vivo. Fubin Li, Jeffrey V Ravetch. Proc Natl Acad Sci U S A, 2013 Nov 13; 110(48). PMID: 24218606 Free PMC article.
Combining regulatory T cell depletion and inhibitory receptor blockade improves reactivation of exhausted virus-specific CD8+ T cells and efficiently reduces chronic retroviral loads. Kirsten K Dietze, Gennadiy Zelinskyy, +3 authors, Ulf Dittmer. less PLoS Pathog, 2013 Dec 18; 9(12). PMID: 24339778 Free PMC article.
Decreased galectin-9 and increased Tim-3 expression are related to poor prognosis in gastric cancer. Jing Jiang, Mei-Shan Jin, +6 authors, Xueyuan Cao. less PLoS One, 2013 Dec 18; 8(12). PMID: 24339967 Free PMC article.
PD-1 identifies the patient-specific CD8⁺ tumor-reactive repertoire infiltrating human tumors. Alena Gros, Paul F Robbins, +13 authors, Steven A Rosenberg. less J Clin Invest, 2014 Mar 29; 124(5). PMID: 24667641 Free PMC article. Highly Cited.
VISTA is an immune checkpoint molecule for human T cells. J Louise Lines, Eirini Pantazi, +8 authors, Randolph Noelle. less Cancer Res, 2014 Apr 03; 74(7). PMID: 24691993 Free PMC article. Highly Cited.
Treg cells expressing the coinhibitory molecule TIGIT selectively inhibit proinflammatory Th1 and Th17 cell responses. Nicole Joller, Ester Lozano, +13 authors, Vijay K Kuchroo. less Immunity, 2014 Apr 22; 40(4). PMID: 24745333 Free PMC article. Highly Cited.
Anti-CTLA-4 antibodies of IgG2a isotype enhance antitumor activity through reduction of intratumoral regulatory T cells. Mark J Selby, John J Engelhardt, +4 authors, Alan J Korman. less Cancer Immunol Res, 2014 Apr 30; 1(1). PMID: 24777248 Highly Cited.
PD-1 as an immune modulatory receptor. Sheng Yao, Lieping Chen. Cancer J, 2014 Aug 08; 20(4). PMID: 25098286 Free PMC article. Review.
The roles of CD73 in cancer. Zhao-wei Gao, Ke Dong, Hui-zhong Zhang. Biomed Res Int, 2014 Aug 16; 2014. PMID: 25126561 Free PMC article. Review.
IgG subclasses and allotypes: from structure to effector functions. Gestur Vidarsson, Gillian Dekkers, Theo Rispens. Front Immunol, 2014 Nov 05; 5. PMID: 25368619 Free PMC article. Highly Cited. Review.
The immunoreceptor TIGIT regulates antitumor and antiviral CD8(+) T cell effector function. Robert J Johnston, Laetitia Comps-Agrar, +9 authors, Jane L Grogan. less Cancer Cell, 2014 Dec 04; 26(6). PMID: 25465800 Highly Cited.
Conformation of the human immunoglobulin G2 hinge imparts superagonistic properties to immunostimulatory anticancer antibodies. Ann L White, H T Claude Chan, +15 authors, Martin J Glennie. less Cancer Cell, 2014 Dec 17; 27(1). PMID: 25500122 Free PMC article.
Structure of FcγRI in complex with Fc reveals the importance of glycan recognition for high-affinity IgG binding. Jinghua Lu, Jonathan Chu, +3 authors, Peter D Sun. less Proc Natl Acad Sci U S A, 2015 Jan 07; 112(3). PMID: 25561553 Free PMC article.
Confusing signals: recent progress in CTLA-4 biology. Lucy S K Walker, David M Sansom. Trends Immunol, 2015 Jan 15; 36(2). PMID: 25582039 Free PMC article. Highly Cited. Review.
Galectin-3 Shapes Antitumor Immune Responses by Suppressing CD8+ T Cells via LAG-3 and Inhibiting Expansion of Plasmacytoid Dendritic Cells. Theodore Kouo, Lanqing Huang, +4 authors, Elizabeth Jaffee. less Cancer Immunol Res, 2015 Feb 19; 3(4). PMID: 25691328 Free PMC article. Highly Cited.
PD-L1 Expression as a Predictive Biomarker in Cancer Immunotherapy. Sandip Pravin Patel, Razelle Kurzrock. Mol Cancer Ther, 2015 Feb 20; 14(4). PMID: 25695955 Highly Cited. Review.
The Coordinated Actions of TIM-3 on Cancer and Myeloid Cells in the Regulation of Tumorigenicity and Clinical Prognosis in Clear Cell Renal Cell Carcinomas. Yoshihiro Komohara, Tomoko Morita, +11 authors, Masahisa Jinushi. less Cancer Immunol Res, 2015 Mar 19; 3(9). PMID: 25783986
Immune checkpoint blockade: a common denominator approach to cancer therapy. Suzanne L Topalian, Charles G Drake, Drew M Pardoll. Cancer Cell, 2015 Apr 11; 27(4). PMID: 25858804 Free PMC article. Highly Cited. Review.
TIGIT and PD-1 impair tumor antigen-specific CD8⁺ T cells in melanoma patients. Joe-Marc Chauvin, Ornella Pagliano, +8 authors, Hassane M Zarour. less J Clin Invest, 2015 Apr 14; 125(5). PMID: 25866972 Free PMC article. Highly Cited.
Ipilimumab-dependent cell-mediated cytotoxicity of regulatory T cells ex vivo by nonclassical monocytes in melanoma patients. Emanuela Romano, Monika Kusio-Kobialka, +7 authors, Daniel E Speiser. less Proc Natl Acad Sci U S A, 2015 Apr 29; 112(19). PMID: 25918390 Free PMC article. Highly Cited.
Immune-checkpoint proteins VISTA and PD-1 nonredundantly regulate murine T-cell responses. Jun Liu, Ying Yuan, +8 authors, Li Wang. less Proc Natl Acad Sci U S A, 2015 May 13; 112(21). PMID: 25964334 Free PMC article. Highly Cited.
PD-L1 blockade for cancer treatment: MEDI4736. Ramy Ibrahim, Ross Stewart, Aiman Shalabi. Semin Oncol, 2015 May 13; 42(3). PMID: 25965366 Review.
Antibody-Dependent Cellular Cytotoxicity Activity of a Novel Anti-PD-L1 Antibody Avelumab (MSB0010718C) on Human Tumor Cells. Benjamin Boyerinas, Caroline Jochems, +4 authors, Jeffrey Schlom. less Cancer Immunol Res, 2015 May 28; 3(10). PMID: 26014098 Free PMC article. Highly Cited.
CD73 Expression Is an Independent Prognostic Factor in Prostate Cancer. Bruno G Leclerc, Roxanne Charlebois, +4 authors, John Stagg. less Clin Cancer Res, 2015 Aug 09; 22(1). PMID: 26253870
Comprehensive Analysis of the Therapeutic IgG4 Antibody Pembrolizumab: Hinge Modification Blocks Half Molecule Exchange In Vitro and In Vivo. Xiaoyu Yang, Fengqiang Wang, +12 authors, Alexandre Ambrogelly. less J Pharm Sci, 2015 Aug 27; 104(12). PMID: 26308749
FcγRs Modulate the Anti-tumor Activity of Antibodies Targeting the PD-1/PD-L1 Axis. Rony Dahan, Emanuela Sega, +3 authors, Jeffrey V Ravetch. less Cancer Cell, 2015 Sep 17; 28(3). PMID: 26373277 Highly Cited.
TIGIT predominantly regulates the immune response via regulatory T cells. Sema Kurtulus, Kaori Sakuishi, +6 authors, Ana C Anderson. less J Clin Invest, 2015 Sep 29; 125(11). PMID: 26413872 Free PMC article. Highly Cited.
The many faces of FcγRI: implications for therapeutic antibody function. Jennifer F A Swisher, Gerald M Feldman. Immunol Rev, 2015 Oct 27; 268(1). PMID: 26497519 Review.
Influence of immunoglobulin isotype on therapeutic antibody function. Stephen A Beers, Martin J Glennie, Ann L White. Blood, 2016 Jan 15; 127(9). PMID: 26764357 Free PMC article. Review.
Inhibition of CD73 AMP hydrolysis by a therapeutic antibody with a dual, non-competitive mechanism of action. James C Geoghegan, Gundo Diedrich, +5 authors, Melissa M Damschroder. less MAbs, 2016 Feb 09; 8(3). PMID: 26854859 Free PMC article.
Adaptive resistance to therapeutic PD-1 blockade is associated with upregulation of alternative immune checkpoints. Shohei Koyama, Esra A Akbay, +23 authors, Peter S Hammerman. less Nat Commun, 2016 Feb 18; 7. PMID: 26883990 Free PMC article. Highly Cited.
Immunoglobulin isotype knowledge and application to Fc engineering. Randall J Brezski, George Georgiou. Curr Opin Immunol, 2016 Mar 24; 40. PMID: 27003675 Review.
Anti-CD73 in cancer immunotherapy: awakening new opportunities. Luca Antonioli, Gennady G Yegutkin, +2 authors, Pál Pacher, Corrado Blandizzi, György Haskó. less Trends Cancer, 2016 Mar 26; 2(2). PMID: 27014745 Free PMC article. Highly Cited.
Lag-3, Tim-3, and TIGIT: Co-inhibitory Receptors with Specialized Functions in Immune Regulation. Ana C Anderson, Nicole Joller, Vijay K Kuchroo. Immunity, 2016 May 19; 44(5). PMID: 27192565 Free PMC article. Highly Cited. Review.
CD73-adenosine reduces immune responses and survival in ovarian cancer patients. Pierre-Olivier Gaudreau, Bertrand Allard, Martin Turcotte, John Stagg. Oncoimmunology, 2016 Jul 29; 5(5). PMID: 27467942 Free PMC article.
CD73 is associated with poor prognosis in HNSCC. Zhen-Hu Ren, Cheng-Zhong Lin, +12 authors, Chen-Ping Zhang. less Oncotarget, 2016 Aug 25; 7(38). PMID: 27557512 Free PMC article.
Targeting CD73 in the tumor microenvironment with MEDI9447. Carl M Hay, Erin Sult, +15 authors, Kris F Sachsenmeier. less Oncoimmunology, 2016 Sep 14; 5(8). PMID: 27622077 Free PMC article. Highly Cited.
Hyperprogressive Disease Is a New Pattern of Progression in Cancer Patients Treated by Anti-PD-1/PD-L1. Stéphane Champiat, Laurent Dercle, +8 authors, Charles Ferté. less Clin Cancer Res, 2016 Nov 09; 23(8). PMID: 27827313 Highly Cited.
Atezolizumab: A PD-L1-Blocking Antibody for Bladder Cancer. Brant A Inman, Thomas A Longo, Sundhar Ramalingam, Michael R Harrison. Clin Cancer Res, 2016 Dec 03; 23(8). PMID: 27903674 Review.
Prognostic impact of CD73 and A2A adenosine receptor expression in non-small-cell lung cancer. Yusuke Inoue, Katsuhiro Yoshimura, +10 authors, Haruhiko Sugimura. less Oncotarget, 2017 Jan 07; 8(5). PMID: 28060732 Free PMC article. Highly Cited.
Adaptive resistance to anti-PD1 therapy by Tim-3 upregulation is mediated by the PI3K-Akt pathway in head and neck cancer. Gulidanna Shayan, Raghvendra Srivastava, +3 authors, Robert L Ferris. less Oncoimmunology, 2017 Feb 16; 6(1). PMID: 28197389 Free PMC article. Highly Cited.
CD73 promotes proliferation and migration of human cervical cancer cells independent of its enzyme activity. Zhao-Wei Gao, Hui-Ping Wang, +4 authors, Ke Dong. less BMC Cancer, 2017 Feb 17; 17(1). PMID: 28202050 Free PMC article.
Tim-3 and its role in regulating anti-tumor immunity. Madhumita Das, Chen Zhu, Vijay K Kuchroo. Immunol Rev, 2017 Mar 05; 276(1). PMID: 28258697 Free PMC article. Highly Cited. Review.
Eradication of Tumors through Simultaneous Ablation of CD276/B7-H3-Positive Tumor Cells and Tumor Vasculature. Steven Seaman, Zhongyu Zhu, +24 authors, Brad St Croix. less Cancer Cell, 2017 Apr 12; 31(4). PMID: 28399408 Free PMC article. Highly Cited.
Hyperprogression during anti-PD-1/PD-L1 therapy in patients with recurrent and/or metastatic head and neck squamous cell carcinoma. E Saâda-Bouzid, C Defaucheux, +11 authors, C Le Tourneau. less Ann Oncol, 2017 Apr 19; 28(7). PMID: 28419181 Highly Cited.
In vivo imaging reveals a tumor-associated macrophage-mediated resistance pathway in anti-PD-1 therapy. Sean P Arlauckas, Christopher S Garris, +9 authors, Mikael J Pittet. less Sci Transl Med, 2017 May 12; 9(389). PMID: 28490665 Free PMC article. Highly Cited.
Selective activation of anti-CD73 mechanisms in control of primary tumors and metastases. Dipti Vijayan, Deborah S Barkauskas, +7 authors, Mark J Smyth. less Oncoimmunology, 2017 Jun 24; 6(5). PMID: 28638737 Free PMC article.
Inhibition of the B7-H3 immune checkpoint limits tumor growth by enhancing cytotoxic lymphocyte function. Young-Hee Lee, Natalia Martin-Orozco, +23 authors, Chen Dong. less Cell Res, 2017 Jul 08; 27(8). PMID: 28685773 Free PMC article. Highly Cited.
FcγRs Modulate the Anti-tumor Activity of Antibodies Targeting the PD-1/PD-L1 Axis. Rony Dahan, Emanuela Sega, +3 authors, Jeffrey V Ravetch. less Cancer Cell, 2015 Oct 12; 28(4). PMID: 28854351
Soluble CD73 as biomarker in patients with metastatic melanoma patients treated with nivolumab. Silvana Morello, Mariaelena Capone, +6 authors, Paolo Antonio Ascierto. less J Transl Med, 2017 Dec 06; 15(1). PMID: 29202855 Free PMC article.
Development of PD-1 and PD-L1 inhibitors as a form of cancer immunotherapy: a comprehensive review of registration trials and future considerations. Jun Gong, Alexander Chehrazi-Raffle, Srikanth Reddi, Ravi Salgia. J Immunother Cancer, 2018 Jan 24; 6(1). PMID: 29357948 Free PMC article. Highly Cited. Review.
Uncoupling therapeutic from immunotherapy-related adverse effects for safer and effective anti-CTLA-4 antibodies in CTLA4 humanized mice. Xuexiang Du, Mingyue Liu, +8 authors, Pan Zheng. less Cell Res, 2018 Feb 22; 28(4). PMID: 29463898 Free PMC article. Highly Cited.
A reappraisal of CTLA-4 checkpoint blockade in cancer immunotherapy. Xuexiang Du, Fei Tang, +14 authors, Yang Liu. less Cell Res, 2018 Feb 24; 28(4). PMID: 29472691 Free PMC article. Highly Cited.
Next generation of immune checkpoint therapy in cancer: new developments and challenges. Julian A Marin-Acevedo, Bhagirathbhai Dholaria, +3 authors, Yanyan Lou. less J Hematol Oncol, 2018 Mar 17; 11(1). PMID: 29544515 Free PMC article. Highly Cited. Review.
Potent Immune Modulation by MEDI6383, an Engineered Human OX40 Ligand IgG4P Fc Fusion Protein. Michael D Oberst, Catherine Augé, +19 authors, Scott A Hammond. less Mol Cancer Ther, 2018 Mar 17; 17(5). PMID: 29545330 Free PMC article.
Nivolumab plus Ipilimumab versus Sunitinib in Advanced Renal-Cell Carcinoma. Robert J Motzer, Nizar M Tannir, +30 authors, CheckMate 214 Investigators. less N Engl J Med, 2018 Mar 22; 378(14). PMID: 29562145 Free PMC article. Highly Cited.
Fc Effector Function Contributes to the Activity of Human Anti-CTLA-4 Antibodies. Frederick Arce Vargas, Andrew J S Furness, +32 authors, Sergio A Quezada. less Cancer Cell, 2018 Mar 27; 33(4). PMID: 29576375 Free PMC article. Highly Cited.
Nivolumab plus Ipilimumab in Lung Cancer with a High Tumor Mutational Burden. Matthew D Hellmann, Tudor-Eliade Ciuleanu, +21 authors, Luis Paz-Ares. less N Engl J Med, 2018 Apr 17; 378(22). PMID: 29658845 Free PMC article. Highly Cited.
The binding of an anti-PD-1 antibody to FcγRΙ has a profound impact on its biological functions. Tong Zhang, Xiaomin Song, +20 authors, Kang Li. less Cancer Immunol Immunother, 2018 Apr 25; 67(7). PMID: 29687231 Free PMC article.
Mechanisms of inside-out signaling of the high-affinity IgG receptor FcγRI. Arianne M Brandsma, Samantha L Schwartz, +7 authors, Jeanette H W Leusen. less Sci Signal, 2018 Jul 26; 11(540). PMID: 30042128 Free PMC article.
Anti-CTLA-4 Immunotherapy Does Not Deplete FOXP3+ Regulatory T Cells (Tregs) in Human Cancers. Anu Sharma, Sumit K Subudhi, +6 authors, Padmanee Sharma. less Clin Cancer Res, 2018 Jul 29; 25(4). PMID: 30054281 Free PMC article. Highly Cited.
Glyco-Engineered Anti-Human Programmed Death-Ligand 1 Antibody Mediates Stronger CD8 T Cell Activation Than Its Normal Glycosylated and Non-Glycosylated Counterparts. Christoph Goletz, Timo Lischke, +4 authors, Steffen Goletz. less Front Immunol, 2018 Aug 01; 9. PMID: 30061887 Free PMC article.
Fundamental Mechanisms of Immune Checkpoint Blockade Therapy. Spencer C Wei, Colm R Duffy, James P Allison. Cancer Discov, 2018 Aug 18; 8(9). PMID: 30115704 Highly Cited. Review.
Hyperprogressive Disease in Patients With Advanced Non-Small Cell Lung Cancer Treated With PD-1/PD-L1 Inhibitors or With Single-Agent Chemotherapy. Roberto Ferrara, Laura Mezquita, +25 authors, Caroline Caramella. less JAMA Oncol, 2018 Sep 08; 4(11). PMID: 30193240 Free PMC article. Highly Cited.
Antibody-Fc/FcR Interaction on Macrophages as a Mechanism for Hyperprogressive Disease in Non-small Cell Lung Cancer Subsequent to PD-1/PD-L1 Blockade. Giuseppe Lo Russo, Massimo Moro, +26 authors, Marina Chiara Garassino. less Clin Cancer Res, 2018 Sep 13; 25(3). PMID: 30206165 Highly Cited.
Differential regulation of PD-L1 expression by immune and tumor cells in NSCLC and the response to treatment with atezolizumab (anti-PD-L1). Marcin Kowanetz, Wei Zou, +27 authors, Priti S Hegde. less Proc Natl Acad Sci U S A, 2018 Oct 10; 115(43). PMID: 30297397 Free PMC article. Highly Cited.
Fibrinogen-like Protein 1 Is a Major Immune Inhibitory Ligand of LAG-3. Jun Wang, Miguel F Sanmamed, +18 authors, Lieping Chen. less Cell, 2018 Dec 26; 176(1-2). PMID: 30580966 Free PMC article. Highly Cited.
CD4/major histocompatibility complex class II interaction analyzed with CD4- and lymphocyte activation gene-3 (LAG-3)-Ig fusion proteins. B Huard, P Prigent, +2 authors, M Tournier, D Bruniquel, F Triebel. less Eur J Immunol, 1995 Sep 01; 25(9). PMID: 7589152
The generation of a humanized, non-mitogenic CD3 monoclonal antibody which retains in vitro immunosuppressive properties. S Bolt, E Routledge, +5 authors, H Waldmann. less Eur J Immunol, 1993 Feb 01; 23(2). PMID: 8436176
Expression of the PD-1 antigen on the surface of stimulated mouse T and B lymphocytes. Y Agata, A Kawasaki, +4 authors, T Honjo. less Int Immunol, 1996 May 01; 8(5). PMID: 8671665 Highly Cited.
Fc gammaRIIIa-158V/F polymorphism influences the binding of IgG by natural killer cell Fc gammaRIIIa, independently of the Fc gammaRIIIa-48L/R/H phenotype. H R Koene, M Kleijer, +3 authors, J Algra, D Roos, A E von dem Borne, M de Haas. less Blood, 1997 Aug 01; 90(3). PMID: 9242542 Highly Cited.
A novel polymorphism of FcgammaRIIIa (CD16) alters receptor function and predisposes to autoimmune disease. J Wu, J C Edberg, +5 authors, R P Kimberly. less J Clin Invest, 1997 Sep 01; 100(5). PMID: 9276722 Free PMC article. Highly Cited.

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