Review
. 2019 Mar;393(10177).
doi: 10.1016/S0140-6736(18)32552-2.

Epithelial ovarian cancer

Stephanie Lheureux 1 Charlie Gourley 2 Ignace Vergote 3 Amit M Oza 4 
Affiliations
  • PMID: 30910306
  •     136 citations

Abstract

Epithelial ovarian cancer generally presents at an advanced stage and is the most common cause of gynaecological cancer death. Treatment requires expert multidisciplinary care. Population-based screening has been ineffective, but new approaches for early diagnosis and prevention that leverage molecular genomics are in development. Initial therapy includes surgery and adjuvant therapy. Epithelial ovarian cancer is composed of distinct histological subtypes with unique genomic characteristics, which are improving the precision and effectiveness of therapy, allowing discovery of predictors of response such as mutations in breast cancer susceptibility genes BRCA1 and BRCA2, and homologous recombination deficiency for DNA damage response pathway inhibitors or resistance (cyclin E1). Rapidly evolving techniques to measure genomic changes in tumour and blood allow for assessment of sensitivity and emergence of resistance to therapy, and might be accurate indicators of residual disease. Recurrence is usually incurable, and patient symptom control and quality of life are key considerations at this stage. Treatments for recurrence have to be designed from a patient's perspective and incorporate meaningful measures of benefit. Urgent progress is needed to develop evidence and consensus-based treatment guidelines for each subgroup, and requires close international cooperation in conducting clinical trials through academic research groups such as the Gynecologic Cancer Intergroup.

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Identification of the Hub Genes Associated with the Prognosis of Ovarian Cancer Patients via Integrated Bioinformatics Analysis and Experimental Validation.
Yuzi Zhao, Jie Pi, +3 authors, Li Hong.
Cancer Manag Res, 2021 Feb 06; 13. PMID: 33542655    Free PMC article.
Loss of Tenascin-X expression during tumor progression: A new pan-cancer marker.
Sophie Liot, Alexandre Aubert, +5 authors, Elise Lambert.
Matrix Biol Plus, 2021 Feb 06; 6-7. PMID: 33543019    Free PMC article.
A Novel Salt Inducible Kinase 2 Inhibitor, ARN-3261, Sensitizes Ovarian Cancer Cell Lines and Xenografts to Carboplatin.
Dengxuan Fan, Hailing Yang, +7 authors, Zhen Lu.
Cancers (Basel), 2021 Jan 29; 13(3). PMID: 33503955    Free PMC article.
Neoadjuvant therapy of BRCA1-driven ovarian cancer by combination of cisplatin, mitomycin C and doxorubicin.
Tatiana V Gorodnova, Anna P Sokolenko, +7 authors, Evgeny N Imyanitov.
Hered Cancer Clin Pract, 2021 Feb 05; 19(1). PMID: 33536037    Free PMC article.
Establishment and validation of an RNA binding protein-associated prognostic model for ovarian cancer.
Chaofan He, Fuxin Huang, +3 authors, Meng Liang.
J Ovarian Res, 2021 Feb 09; 14(1). PMID: 33550985    Free PMC article.
Low junctional adhesion molecule-A expression is associated with an epithelial to mesenchymal transition and poorer outcomes in high-grade serous carcinoma of uterine adnexa.
Laudine Communal, Mauricio Medrano, +11 authors, Anne-Marie Mes-Masson.
Mod Pathol, 2020 Jun 10; 33(11). PMID: 32514162
MicroRNA-377-3p targeting MMP-16 inhibits ovarian cancer cell growth, invasion, and interstitial transition.
Huabin Wang, Changmin Qi, Dan Wan.
Ann Transl Med, 2021 Feb 12; 9(2). PMID: 33569426    Free PMC article.
A Modified 2 Tier Chemotherapy Response Score (CRS) and Other Histopathologic Features for Predicting Outcomes of Patients with Advanced Extrauterine High-Grade Serous Carcinoma after Neoadjuvant Chemotherapy.
Yanping Zhong, Jinsong Liu, +8 authors, Nicole D Fleming.
Cancers (Basel), 2021 Feb 13; 13(4). PMID: 33572451    Free PMC article.
The use of neoadjuvant chemotherapy in advanced endometrial cancer.
L Philp, A Kanbergs, +3 authors, A Goodman.
Gynecol Oncol Rep, 2021 Mar 02; 36. PMID: 33644284    Free PMC article.
Identification of LncRNA Prognostic Markers for Ovarian Cancer by Integration of Co-expression and CeRNA Network.
Huisheng Liang, Yuquan Bai, Hailong Wang, Xiangjun Yang.
Front Genet, 2021 Mar 06; 11. PMID: 33664764    Free PMC article.
Biocompatible AIEgen/p-glycoprotein siRNA@reduction-sensitive paclitaxel polymeric prodrug nanoparticles for overcoming chemotherapy resistance in ovarian cancer.
Jun Wu, Quan Wang, +10 authors, Jun Dai.
Theranostics, 2021 Mar 06; 11(8). PMID: 33664857    Free PMC article.
A novel biomarker, MRPS12 functions as a potential oncogene in ovarian cancer and is a promising prognostic candidate.
Xiaofeng Qiu, Dongxia Guo, +2 authors, Fengying Wang.
Medicine (Baltimore), 2021 Mar 06; 100(8). PMID: 33663122    Free PMC article.
Prognostic Significance of Survivin Expression in Patients with Ovarian Carcinoma: A Meta-Analysis.
Beata Gąsowska-Bajger, Agnieszka Gąsowska-Bodnar, Paweł Knapp, Lubomir Bodnar.
J Clin Med, 2021 Mar 07; 10(4). PMID: 33669912    Free PMC article.
Review.
Long non‑coding RNA ASAP1‑IT1 suppresses ovarian cancer progression by regulating Hippo/YAP signaling.
Ke Wang, Yu-Bo Hu, Ye Zhao, Cong Ye.
Int J Mol Med, 2021 Feb 13; 47(4). PMID: 33576454    Free PMC article.
Development and Validation of an Immune-Related Gene-Pair Model of High-Grade Serous Ovarian Cancer After Platinum-Based Chemotherapy.
Jiaxing Lin, Xiao Xu, Dan Sun, Tianren Li.
Front Oncol, 2021 Mar 09; 10. PMID: 33680950    Free PMC article.
Construction autophagy-related prognostic risk signature to facilitate survival prediction, individual treatment and biomarker excavation of epithelial ovarian cancer patients.
Hongjun Fei, Songchang Chen, Chenming Xu.
J Ovarian Res, 2021 Mar 08; 14(1). PMID: 33676525    Free PMC article.
Enhancing delivery of small molecule and cell-based therapies for ovarian cancer using advanced delivery strategies.
Joanne O'Dwyer, Roisin E O'Cearbhaill, +4 authors, Eimear B Dolan.
Adv Ther (Weinh), 2021 Mar 13; 3(11). PMID: 33709016    Free PMC article.
Deregulation of angiopoietin-like 4 slows ovarian cancer progression through vascular endothelial growth factor receptor 2 phosphorylation.
Yuxian Wu, Jinghai Gao, Xiaojun Liu.
Cancer Cell Int, 2021 Mar 18; 21(1). PMID: 33726754    Free PMC article.
SIRT1 and gynecological malignancies (Review).
Jiayu Chen, Houzao Chen, Lingya Pan.
Oncol Rep, 2021 Mar 03; 45(4). PMID: 33649834    Free PMC article.
Clinicopathological and immunological characterization of RNA m6 A methylation regulators in ovarian cancer.
Qingying Wang, Qinyi Zhang, +2 authors, Jiawen Zhang.
Mol Genet Genomic Med, 2020 Nov 24; 9(1). PMID: 33225598    Free PMC article.
Comparison of the survival outcomes of laparoscopy versus laparotomy in treatment of early-stage ovarian cancer: a systematic review and meta-analysis.
Qingduo Kong, Hongyi Wei, +2 authors, Yongjun Wang.
J Ovarian Res, 2021 Mar 18; 14(1). PMID: 33726795    Free PMC article.
Review.
Circular RNA ABCB10 promotes cell proliferation and invasion, but inhibits apoptosis via regulating the microRNA‑1271‑mediated Capn4/Wnt/β‑catenin signaling pathway in epithelial ovarian cancer.
Xuefang Lin, Yan Chen, Xiabin Ye, Xuemei Xia.
Mol Med Rep, 2021 Mar 25; 23(5). PMID: 33760208    Free PMC article.
OPCML Methylation and the Risk of Ovarian Cancer: A Meta and Bioinformatics Analysis.
Yang Shao, Jing Kong, +7 authors, Jiangping Wu.
Front Cell Dev Biol, 2021 Mar 30; 9. PMID: 33777925    Free PMC article.
Systematic Review.
Tumor Immunometabolism Characterization in Ovarian Cancer With Prognostic and Therapeutic Implications.
Miner Yang, Gaowen Chen, Kunjie Gao, Yifeng Wang.
Front Oncol, 2021 Apr 03; 11. PMID: 33796460    Free PMC article.
Preclinical Verification of the Efficacy and Safety of Aqueous Plasma for Ovarian Cancer Therapy.
Kae Nakamura, Nobuhisa Yoshikawa, +7 authors, Hiroaki Kajiyama.
Cancers (Basel), 2021 Apr 04; 13(5). PMID: 33799991    Free PMC article.
The Role of Myeloid-Derived Suppressor Cells (MDSCs) in the Development and/or Progression of Endometriosis-State of the Art.
Dorota Suszczyk, Wiktoria Skiba, +2 authors, Iwona Wertel.
Cells, 2021 Apr 04; 10(3). PMID: 33803806    Free PMC article.
Review.
Low Expression of Circular RNA hsa_circ_0078607 Predicts Poor Prognosis in High-Grade Serous Ovarian Cancer.
Nan Zhang, Zhiyou Yang, +3 authors, Yu Wang.
Cancer Manag Res, 2021 Apr 10; 13. PMID: 33833570    Free PMC article.
Triptolide inhibits JAK2/STAT3 signaling and induces lethal autophagy through ROS generation in cisplatin‑resistant SKOV3/DDP ovarian cancer cells.
Yanying Zhong, Fuyin Le, +6 authors, Buzhen Tan.
Oncol Rep, 2021 Mar 25; 45(5). PMID: 33760192    Free PMC article.
Prognostic Evidence of the miRNA-Based Ovarian Cancer Signature MiROvaR in Independent Datasets.
Loris De Cecco, Marina Bagnoli, +2 authors, Delia Mezzanzanica.
Cancers (Basel), 2021 Apr 04; 13(7). PMID: 33801595    Free PMC article.
HSP90 identified by a proteomic approach as druggable target to reverse platinum resistance in ovarian cancer.
Rita Lombardi, Maura Sonego, +12 authors, Alfredo Budillon.
Mol Oncol, 2020 Dec 18; 15(4). PMID: 33331136    Free PMC article.
Splicing factor USP39 promotes ovarian cancer malignancy through maintaining efficient splicing of oncogenic HMGA2.
Shourong Wang, Zixiang Wang, +9 authors, Zhaojian Liu.
Cell Death Dis, 2021 Mar 19; 12(4). PMID: 33731694    Free PMC article.
Identification and Development of Subtypes With Poor Prognosis in Pan-Gynecological Cancer Based on Gene Expression in the Glycolysis-Cholesterol Synthesis Axis.
Guangwei Wang, Xiaofei Liu, +2 authors, Qing Yang.
Front Oncol, 2021 Apr 13; 11. PMID: 33842342    Free PMC article.
ATR and p-ATR are emerging prognostic biomarkers and DNA damage response targets in ovarian cancer.
Wenlong Feng, Dylan C Dean, +4 authors, Huirong Shi.
Ther Adv Med Oncol, 2021 Apr 16; 12. PMID: 33854565    Free PMC article.
Utility of Preoperative Inflammatory Markers to Distinguish Epithelial Ovarian Cancer from Benign Ovarian Masses.
Lian Li, Jing Tian, +6 authors, Kexin Chen.
J Cancer, 2021 Apr 16; 12(9). PMID: 33854628    Free PMC article.
A Novel Defined Risk Signature of the Ferroptosis-Related Genes for Predicting the Prognosis of Ovarian Cancer.
Ying Ye, Qinjin Dai, +2 authors, Hongbo Qi.
Front Mol Biosci, 2021 Apr 20; 8. PMID: 33869286    Free PMC article.