Review
. 2019 Apr; 1461(1):73-103.
doi: 10.1111/nyas.14106.

Type 1 diabetes pathogenesis and the role of inhibitory receptors in islet tolerance

Tijana Martinov 1 Brian T Fife 1 
Affiliations
  • PMID: 31025378
  •     397 References
  •     5 citations

Abstract

Type 1 diabetes (T1D) affects over a million Americans, and disease incidence is on the rise. Despite decades of research, there is still no cure for this disease. Exciting beta cell replacement strategies are being developed, but in order for such approaches to work, targeted immunotherapies must be designed. To selectively halt the autoimmune response, researchers must first understand how this response is regulated and which tolerance checkpoints fail during T1D development. Herein, we discuss the current understanding of T1D pathogenesis in humans, genetic and environmental risk factors, presumed roles of CD4+ and CD8+ T cells as well as B cells, and implicated autoantigens. We also highlight studies in non-obese diabetic mice that have demonstrated the requirement for CD4+ and CD8+ T cells and B cells in driving T1D pathology. We present an overview of central and peripheral tolerance mechanisms and comment on existing controversies in the field regarding central tolerance. Finally, we discuss T cell- and B cell-intrinsic tolerance mechanisms, with an emphasis on the roles of inhibitory receptors in maintaining islet tolerance in humans and in diabetes-prone mice, and strategies employed to date to harness inhibitory receptor signaling to prevent or reverse T1D.

Keywords: cytotoxic T lymphocyte-associated protein-4; lymphocyte activation gene-3; non-obese diabetic mice; programmed death-1; tolerance; type 1 diabetes.

Autoimmune dilated cardiomyopathy in PD-1 receptor-deficient mice.
H Nishimura, T Okazaki, +8 authors, T Honjo.
Science, 2001 Feb 24; 291(5502). PMID: 11209085
Highly Cited.
Inhibition of T cell activation and autoimmune diabetes using a B cell surface-linked CTLA-4 agonist.
Brian T Fife, Matthew D Griffin, +2 authors, Jeffrey A Bluestone.
J Clin Invest, 2006 Aug 04; 116(8). PMID: 16886063    Free PMC article.
Monoclonal antibody blocking the recognition of an insulin peptide-MHC complex modulates type 1 diabetes.
Li Zhang, Frances Crawford, +5 authors, George S Eisenbarth.
Proc Natl Acad Sci U S A, 2014 Feb 20; 111(7). PMID: 24550292    Free PMC article.
Do MHCII-presented neoantigens drive type 1 diabetes and other autoimmune diseases?
Philippa Marrack, John W Kappler.
Cold Spring Harb Perspect Med, 2012 Sep 07; 2(9). PMID: 22951444    Free PMC article.
Review.
Chromogranin A is an autoantigen in type 1 diabetes.
Brian D Stadinski, Thomas Delong, +11 authors, Kathryn Haskins.
Nat Immunol, 2010 Feb 09; 11(3). PMID: 20139986    Free PMC article.
Highly Cited.
Responses against islet antigens in NOD mice are prevented by tolerance to proinsulin but not IGRP.
Balasubramanian Krishnamurthy, Nadine L Dudek, +8 authors, Thomas W H Kay.
J Clin Invest, 2006 Dec 05; 116(12). PMID: 17143333    Free PMC article.
Cutting edge: accelerated autoimmune diabetes in the absence of LAG-3.
Maria Bettini, Andrea L Szymczak-Workman, +6 authors, Dario A A Vignali.
J Immunol, 2011 Aug 30; 187(7). PMID: 21873518    Free PMC article.
Incidence of diabetes in youth in the United States.
Writing Group for the SEARCH for Diabetes in Youth Study Group, Dana Dabelea, +10 authors, Beth Waitzfelder.
JAMA, 2007 Jun 28; 297(24). PMID: 17595272
Highly Cited.
Beta 2-microglobulin-deficient NOD mice do not develop insulitis or diabetes.
L S Wicker, E H Leiter, +7 authors, L B Peterson.
Diabetes, 1994 Mar 01; 43(3). PMID: 8314024
The B7-independent isoform of CTLA-4 functions to regulate autoimmune diabetes.
Melanie Stumpf, Xuyu Zhou, Jeffrey A Bluestone.
J Immunol, 2013 Jan 08; 190(3). PMID: 23293354    Free PMC article.
Targeting Anti-Insulin B Cell Receptors Improves Receptor Editing in Type 1 Diabetes-Prone Mice.
Rachel H Bonami, James W Thomas.
J Immunol, 2015 Oct 04; 195(10). PMID: 26432895    Free PMC article.
Antithymocyte globulin treatment for patients with recent-onset type 1 diabetes: 12-month results of a randomised, placebo-controlled, phase 2 trial.
Stephen E Gitelman, Peter A Gottlieb, +15 authors, START Study Team.
Lancet Diabetes Endocrinol, 2014 Mar 14; 1(4). PMID: 24622416    Free PMC article.
Highly Cited.
Insulin VNTR allele-specific effect in type 1 diabetes depends on identity of untransmitted paternal allele. The IMDIAB Group.
S T Bennett, A J Wilson, +15 authors, J A Todd.
Nat Genet, 1997 Nov 14; 17(3). PMID: 9354805
The prevalence of type 1 diabetes in the United States.
Andy Menke, Trevor J Orchard, +3 authors, Catherine C Cowie.
Epidemiology, 2013 Aug 02; 24(5). PMID: 23903880    Free PMC article.
Generalized resistance to thymic deletion in the NOD mouse; a polygenic trait characterized by defective induction of Bim.
Adrian Liston, Sylvie Lesage, +11 authors, Christopher C Goodnow.
Immunity, 2004 Dec 14; 21(6). PMID: 15589170
Coxsackie B4 virus infection of beta cells and natural killer cell insulitis in recent-onset type 1 diabetic patients.
Francesco Dotta, Stefano Censini, +12 authors, Piero Marchetti.
Proc Natl Acad Sci U S A, 2007 Mar 16; 104(12). PMID: 17360338    Free PMC article.
Highly Cited.
Identification of the beta cell antigen targeted by a prevalent population of pathogenic CD8+ T cells in autoimmune diabetes.
Scott M Lieberman, Anne M Evans, +9 authors, Teresa P DiLorenzo.
Proc Natl Acad Sci U S A, 2003 Jun 20; 100(14). PMID: 12815107    Free PMC article.
Highly Cited.
Restoring function in exhausted CD8 T cells during chronic viral infection.
Daniel L Barber, E John Wherry, +5 authors, Rafi Ahmed.
Nature, 2005 Dec 31; 439(7077). PMID: 16382236
Highly Cited.
Circulating CXCR5+PD-1+ICOS+ Follicular T Helper Cells Are Increased Close to the Diagnosis of Type 1 Diabetes in Children With Multiple Autoantibodies.
Tyyne Viisanen, Emmi-Leena Ihantola, +11 authors, Tuure Kinnunen.
Diabetes, 2017 Jan 22; 66(2). PMID: 28108610
LAG-3, a novel lymphocyte activation gene closely related to CD4.
F Triebel, S Jitsukawa, +4 authors, T Hercend.
J Exp Med, 1990 May 01; 171(5). PMID: 1692078    Free PMC article.
Highly Cited.
T cell immunity after a viral infection versus T cell tolerance induced by soluble viral peptides.
D Kyburz, P Aichele, +3 authors, H Pircher.
Eur J Immunol, 1993 Aug 01; 23(8). PMID: 8344359
Following the fate of one insulin-reactive CD4 T cell: conversion into Teffs and Tregs in the periphery controls diabetes in NOD mice.
Georgia Fousteri, Jean Jasinski, +10 authors, Matthias von Herrath.
Diabetes, 2012 Mar 10; 61(5). PMID: 22403296    Free PMC article.
IL-21 regulates germinal center B cell differentiation and proliferation through a B cell-intrinsic mechanism.
Dimitra Zotos, Jonathan M Coquet, +9 authors, David M Tarlinton.
J Exp Med, 2010 Feb 10; 207(2). PMID: 20142430    Free PMC article.
Highly Cited.
Positional cloning of the APECED gene.
K Nagamine, P Peterson, +11 authors, N Shimizu.
Nat Genet, 1997 Dec 17; 17(4). PMID: 9398839
Highly Cited.
Type I diabetes mellitus. A chronic autoimmune disease.
G S Eisenbarth.
N Engl J Med, 1986 May 22; 314(21). PMID: 3517648
Highly Cited. Review.
Teplizumab preserves C-peptide in recent-onset type 1 diabetes: two-year results from the randomized, placebo-controlled Protégé trial.
William Hagopian, Robert J Ferry, +9 authors, Protégé Trial Investigators.
Diabetes, 2013 Jun 27; 62(11). PMID: 23801579    Free PMC article.
Highly Cited.
Chronic intestinal inflammatory condition generates IL-10-producing regulatory B cell subset characterized by CD1d upregulation.
Atsushi Mizoguchi, Emiko Mizoguchi, +2 authors, Atul K Bhan.
Immunity, 2002 Mar 01; 16(2). PMID: 11869683
Highly Cited.
Major histocompatibility complex class I-deficient NOD-B2mnull mice are diabetes and insulitis resistant.
D V Serreze, E H Leiter, +2 authors, D C Roopenian.
Diabetes, 1994 Mar 01; 43(3). PMID: 8314025
Highly Cited.
Elimination of germinal-center-derived self-reactive B cells is governed by the location and concentration of self-antigen.
Tyani D Chan, Katherine Wood, +4 authors, Robert Brink.
Immunity, 2012 Nov 13; 37(5). PMID: 23142780
Modulation of redox balance leaves murine diabetogenic TH1 T cells "LAG-3-ing" behind.
Meghan M Delmastro, Alexis J Styche, +3 authors, Jon D Piganelli.
Diabetes, 2012 May 16; 61(7). PMID: 22586584    Free PMC article.
Coregulation of CD8+ T cell exhaustion by multiple inhibitory receptors during chronic viral infection.
Shawn D Blackburn, Haina Shin, +7 authors, E John Wherry.
Nat Immunol, 2008 Dec 02; 10(1). PMID: 19043418    Free PMC article.
Highly Cited.
Development of autoimmune diabetes in glutamic acid decarboxylase 65 (GAD65) knockout NOD mice.
T Yamamoto, E Yamato, +6 authors, J-I Miyazaki.
Diabetologia, 2003 Dec 17; 47(2). PMID: 14676944
Islet-Derived CD4 T Cells Targeting Proinsulin in Human Autoimmune Diabetes.
Aaron W Michels, Laurie G Landry, +11 authors, Maki Nakayama.
Diabetes, 2016 Dec 07; 66(3). PMID: 27920090    Free PMC article.
Highly Cited.
LAG3 limits regulatory T cell proliferation and function in autoimmune diabetes.
Qianxia Zhang, Maria Chikina, +7 authors, Dario A A Vignali.
Sci Immunol, 2017 Aug 08; 2(9). PMID: 28783703    Free PMC article.
LAP, a lymphocyte activation gene-3 (LAG-3)-associated protein that binds to a repeated EP motif in the intracellular region of LAG-3, may participate in the down-regulation of the CD3/TCR activation pathway.
N Iouzalen, S Andreae, S Hannier, F Triebel.
Eur J Immunol, 2001 Oct 10; 31(10). PMID: 11592063
New insights into the molecular basis of T cell anergy: anergy factors, avoidance sensors, and epigenetic imprinting.
Andrew D Wells.
J Immunol, 2009 Jun 06; 182(12). PMID: 19494254
Review.
Immunoregulatory mechanisms triggered by viral infections protect from type 1 diabetes in mice.
Christophe M Filippi, Elizabeth A Estes, Janine E Oldham, Matthias G von Herrath.
J Clin Invest, 2009 May 30; 119(6). PMID: 19478458    Free PMC article.
Altered immunoglobulin expression and functional silencing of self-reactive B lymphocytes in transgenic mice.
C C Goodnow, J Crosbie, +7 authors, K Raphael.
Nature, 1988 Aug 25; 334(6184). PMID: 3261841
Highly Cited.
Analysis of self-antigen specificity of islet-infiltrating T cells from human donors with type 1 diabetes.
Jenny Aurielle B Babon, Megan E DeNicola, +21 authors, Sally C Kent.
Nat Med, 2016 Nov 01; 22(12). PMID: 27798614    Free PMC article.
Highly Cited.
B cells activated by lipopolysaccharide, but not by anti-Ig and anti-CD40 antibody, induce anergy in CD8+ T cells: role of TGF-beta 1.
Vrajesh V Parekh, Durbaka V R Prasad, +3 authors, Gyan C Mishra.
J Immunol, 2003 Jun 10; 170(12). PMID: 12794116
The influence of variable-region somatic mutations on the specificity and pathogenicity of murine monoclonal anti-DNA antibodies.
G S Gilkeson, K Bernstein, +5 authors, J B Lefkowith.
Clin Immunol Immunopathol, 1995 Jul 01; 76(1 Pt 1). PMID: 7606869
Signal Transducer and Activator of Transcription 3 Hyperactivation Associates With Follicular Helper T Cell Differentiation and Disease Activity in Rheumatoid Arthritis.
Jun Deng, Chaofan Fan, +19 authors, Di Yu.
Front Immunol, 2018 Jun 20; 9. PMID: 29915585    Free PMC article.
CD4 T Cells Reactive to Hybrid Insulin Peptides Are Indicators of Disease Activity in the NOD Mouse.
Rocky L Baker, Braxton L Jamison, +7 authors, Kathryn Haskins.
Diabetes, 2018 Jul 07; 67(9). PMID: 29976617    Free PMC article.
An intracellular calcium increase and protein kinase C activation fail to initiate T cell proliferation in the absence of a costimulatory signal.
D L Mueller, M K Jenkins, L Chiodetti, R H Schwartz.
J Immunol, 1990 May 15; 144(10). PMID: 1970590
Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes.
Jeffrey C Barrett, David G Clayton, +16 authors, Type 1 Diabetes Genetics Consortium.
Nat Genet, 2009 May 12; 41(6). PMID: 19430480    Free PMC article.
Highly Cited.
Pathogenic CD4 T cells in type 1 diabetes recognize epitopes formed by peptide fusion.
Thomas Delong, Timothy A Wiles, +15 authors, Kathryn Haskins.
Science, 2016 Feb 26; 351(6274). PMID: 26912858    Free PMC article.
Highly Cited.
Germinal centers: programmed for affinity maturation and antibody diversification.
Oliver Bannard, Jason G Cyster.
Curr Opin Immunol, 2017 Jan 16; 45. PMID: 28088708
Highly Cited. Review.
Activation-induced non-responsiveness (anergy) limits CD8 T cell responses to tumors.
Matthew F Mescher, Flavia E Popescu, +2 authors, Julie M Curtsinger.
Semin Cancer Biol, 2007 Jul 28; 17(4). PMID: 17656106    Free PMC article.
Review.
Inflammatory cytokines as a third signal for T cell activation.
Julie M Curtsinger, Matthew F Mescher.
Curr Opin Immunol, 2010 Apr 07; 22(3). PMID: 20363604    Free PMC article.
Highly Cited. Review.
T follicular helper cell differentiation, function, and roles in disease.
Shane Crotty.
Immunity, 2014 Nov 05; 41(4). PMID: 25367570    Free PMC article.
Highly Cited. Review.
The immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome (IPEX) is caused by mutations of FOXP3.
C L Bennett, J Christie, +7 authors, H D Ochs.
Nat Genet, 2001 Jan 04; 27(1). PMID: 11137993
Highly Cited.
CD4/major histocompatibility complex class II interaction analyzed with CD4- and lymphocyte activation gene-3 (LAG-3)-Ig fusion proteins.
B Huard, P Prigent, +2 authors, F Triebel.
Eur J Immunol, 1995 Sep 01; 25(9). PMID: 7589152
Tolerance in T-cell-receptor transgenic mice involves deletion of nonmature CD4+8+ thymocytes.
P Kisielow, H Blüthmann, +2 authors, H von Boehmer.
Nature, 1988 Jun 23; 333(6175). PMID: 3260350
Highly Cited.
Investigation of the role of B-cells in type 1 diabetes in the NOD mouse.
F Susan Wong, Li Wen, +6 authors, Mark J Shlomchik.
Diabetes, 2004 Sep 28; 53(10). PMID: 15448087
Loss of CTLA-4 leads to massive lymphoproliferation and fatal multiorgan tissue destruction, revealing a critical negative regulatory role of CTLA-4.
E A Tivol, F Borriello, +3 authors, A H Sharpe.
Immunity, 1995 Nov 01; 3(5). PMID: 7584144
Highly Cited.
Transient insulin autoantibody expression independent of development of diabetes: comparison of NOD and NOR strains.
N Abiru, L Yu, +4 authors, G S Eisenbarth.
J Autoimmun, 2001 Aug 08; 17(1). PMID: 11488632
PD-1 blockade inhibits hematogenous spread of poorly immunogenic tumor cells by enhanced recruitment of effector T cells.
Yoshiko Iwai, Seigo Terawaki, Tasuku Honjo.
Int Immunol, 2004 Dec 22; 17(2). PMID: 15611321
Highly Cited.
Efficient generation of monoclonal antibodies against peptide in the context of MHCII using magnetic enrichment.
Justin A Spanier, Daniel R Frederick, +10 authors, Brian T Fife.
Nat Commun, 2016 Jun 14; 7. PMID: 27292946    Free PMC article.
Deletion and anergy of polyclonal B cells specific for ubiquitous membrane-bound self-antigen.
Justin J Taylor, Ryan J Martinez, +6 authors, Daniel L Mueller.
J Exp Med, 2012 Oct 17; 209(11). PMID: 23071255    Free PMC article.
IL-10-producing regulatory B cells (B10 cells) in autoimmune disease.
Ioannis Kalampokis, Ayumi Yoshizaki, Thomas F Tedder.
Arthritis Res Ther, 2013 Apr 10; 15 Suppl 1. PMID: 23566714    Free PMC article.
Highly Cited. Review.
Establishment of NOD-Pdcd1-/- mice as an efficient animal model of type I diabetes.
Jian Wang, Taku Yoshida, +3 authors, Tasuku Honjo.
Proc Natl Acad Sci U S A, 2005 Aug 10; 102(33). PMID: 16087865    Free PMC article.
Highly Cited.
IL-21 production by CD4+ effector T cells and frequency of circulating follicular helper T cells are increased in type 1 diabetes patients.
Ricardo C Ferreira, Henry Z Simons, +11 authors, Marcin L Pekalski.
Diabetologia, 2015 Feb 06; 58(4). PMID: 25652388    Free PMC article.
Thymic selection threshold defined by compartmentalization of Ras/MAPK signalling.
Mark A Daniels, Emma Teixeiro, +7 authors, Ed Palmer.
Nature, 2006 Nov 07; 444(7120). PMID: 17086201
Highly Cited.
Lymphocyte-activation gene 3/major histocompatibility complex class II interaction modulates the antigenic response of CD4+ T lymphocytes.
B Huard, M Tournier, +2 authors, F Faure.
Eur J Immunol, 1994 Dec 01; 24(12). PMID: 7805750
An insulin-IAPP hybrid peptide is an endogenous antigen for CD4 T cells in the non-obese diabetic mouse.
Timothy A Wiles, Thomas Delong, +5 authors, Kathryn Haskins.
J Autoimmun, 2016 Nov 03; 78. PMID: 27802879    Free PMC article.
Enteroviruses, type 1 diabetes and hygiene: a complex relationship.
S Tracy, K M Drescher, +2 authors, K Kono.
Rev Med Virol, 2010 Jan 06; 20(2). PMID: 20049905    Free PMC article.
Review.
Characterization of the lymphocyte activation gene 3-encoded protein. A new ligand for human leukocyte antigen class II antigens.
E Baixeras, B Huard, +6 authors, D Piatier-Tonneau.
J Exp Med, 1992 Aug 01; 176(2). PMID: 1380059    Free PMC article.
Highly Cited.
CD4+ T cell tolerance to parenchymal self-antigens requires presentation by bone marrow-derived antigen-presenting cells.
A J Adler, D W Marsh, +4 authors, D M Pardoll.
J Exp Med, 1998 Jun 13; 187(10). PMID: 9584134    Free PMC article.
Immunotherapy of the nonobese diabetic mouse: treatment with an antibody to T-helper lymphocytes.
J A Shizuru, C Taylor-Edwards, +2 authors, C G Fathman.
Science, 1988 Apr 29; 240(4852). PMID: 2966437
Highly Cited.
LAG3 (CD223) as a cancer immunotherapy target.
Lawrence P Andrews, Ariel E Marciscano, Charles G Drake, Dario A A Vignali.
Immunol Rev, 2017 Mar 05; 276(1). PMID: 28258692    Free PMC article.
Highly Cited. Review.
PD-L1 gene polymorphisms and low serum level of PD-L1 protein are associated to type 1 diabetes in Chile.
Carolina Pizarro, Diego F García-Díaz, +3 authors, Francisco Pérez-Bravo.
Diabetes Metab Res Rev, 2014 May 13; 30(8). PMID: 24816853
Genetic deletion of granzyme B does not confer resistance to the development of spontaneous diabetes in non-obese diabetic mice.
M Kobayashi, C Kaneko-Koike, +11 authors, A Kawakami.
Clin Exp Immunol, 2013 May 15; 173(3). PMID: 23663075    Free PMC article.
Regulation of PD-1, PD-L1, and PD-L2 expression during normal and autoimmune responses.
Spencer C Liang, Yvette E Latchman, +4 authors, Arlene H Sharpe.
Eur J Immunol, 2003 Sep 30; 33(10). PMID: 14515254
Highly Cited.
Antithymocyte globulin therapy for patients with recent-onset type 1 diabetes: 2 year results of a randomised trial.
Stephen E Gitelman, Peter A Gottlieb, +14 authors, ITN START Study Team.
Diabetologia, 2016 Apr 08; 59(6). PMID: 27053235    Free PMC article.
Homeostasis and self-tolerance in the immune system: turning lymphocytes off.
L Van Parijs, A K Abbas.
Science, 1998 May 02; 280(5361). PMID: 9535647
Highly Cited. Review.
Cutting edge: CD4 T cells reactive to an islet amyloid polypeptide peptide accumulate in the pancreas and contribute to disease pathogenesis in nonobese diabetic mice.
Rocky L Baker, Thomas Delong, +3 authors, Kathryn Haskins.
J Immunol, 2013 Sep 18; 191(8). PMID: 24043895    Free PMC article.
Where CD4+CD25+ T reg cells impinge on autoimmune diabetes.
Zhibin Chen, Ann E Herman, +2 authors, Christophe Benoist.
J Exp Med, 2005 Nov 23; 202(10). PMID: 16301745    Free PMC article.
Highly Cited.
Antitumor activity in melanoma and anti-self responses in a phase I trial with the anti-cytotoxic T lymphocyte-associated antigen 4 monoclonal antibody CP-675,206.
Antoni Ribas, Luis H Camacho, +10 authors, Jesus Gomez-Navarro.
J Clin Oncol, 2005 Oct 06; 23(35). PMID: 16204013
Highly Cited.
Enterovirus infection in human pancreatic islet cells, islet tropism in vivo and receptor involvement in cultured islet beta cells.
P Ylipaasto, K Klingel, +4 authors, M Roivainen.
Diabetologia, 2004 Jan 17; 47(2). PMID: 14727023
Functional defects and the influence of age on the frequency of CD4+ CD25+ T-cells in type 1 diabetes.
Todd M Brusko, Clive H Wasserfall, +2 authors, Mark A Atkinson.
Diabetes, 2005 Apr 28; 54(5). PMID: 15855327
Highly Cited.
Ectopic Expression of Self-Antigen Drives Regulatory T Cell Development and Not Deletion of Autoimmune T Cells.
Thomas Lee, Maran L Sprouse, +2 authors, Matthew L Bettini.
J Immunol, 2017 Aug 25; 199(7). PMID: 28835461    Free PMC article.
Disabling backache in France, Switzerland, and The Netherlands: contrasting sociopolitical constraints on clinical judgment.
N M Hadler.
J Occup Med, 1989 Oct 01; 31(10). PMID: 2532680
Involvement of PD-L1 on tumor cells in the escape from host immune system and tumor immunotherapy by PD-L1 blockade.
Yoshiko Iwai, Masayoshi Ishida, +3 authors, Nagahiro Minato.
Proc Natl Acad Sci U S A, 2002 Sep 10; 99(19). PMID: 12218188    Free PMC article.
Highly Cited.
Association of the T-cell regulatory gene CTLA4 with susceptibility to autoimmune disease.
Hironori Ueda, Joanna M M Howson, +50 authors, Stephen C L Gough.
Nature, 2003 May 02; 423(6939). PMID: 12724780
Highly Cited.
MHC class II Ab diabetogenic residue 57 Asp/non-Asp dimorphism influences T-cell recognition and selection.
A N Antoniou, J Elliott, E Rosmarakis, P J Dyson.
Immunogenetics, 1998 Mar 07; 47(3). PMID: 9435340
In vitro-expanded antigen-specific regulatory T cells suppress autoimmune diabetes.
Qizhi Tang, Kammi J Henriksen, +7 authors, Jeffrey A Bluestone.
J Exp Med, 2004 Jun 09; 199(11). PMID: 15184499    Free PMC article.
Highly Cited.
Induction of anergic or regulatory tumor-specific CD4+ T cells in the tumor-draining lymph node.
Ruby Alonso, Héloïse Flament, +12 authors, Olivier Lantz.
Nat Commun, 2018 May 31; 9(1). PMID: 29844317    Free PMC article.
Tissue expression of PD-L1 mediates peripheral T cell tolerance.
Mary E Keir, Spencer C Liang, +7 authors, Arlene H Sharpe.
J Exp Med, 2006 Apr 12; 203(4). PMID: 16606670    Free PMC article.
Highly Cited.
Receptor editing in developing T cells.
M A McGargill, J M Derbinski, K A Hogquist.
Nat Immunol, 2001 Mar 23; 1(4). PMID: 11017106
Demonstration of islet-autoreactive CD8 T cells in insulitic lesions from recent onset and long-term type 1 diabetes patients.
Ken T Coppieters, Francesco Dotta, +5 authors, Matthias G von Herrath.
J Exp Med, 2012 Jan 04; 209(1). PMID: 22213807    Free PMC article.
Highly Cited.
Pooled Analysis of Long-Term Survival Data From Phase II and Phase III Trials of Ipilimumab in Unresectable or Metastatic Melanoma.
Dirk Schadendorf, F Stephen Hodi, +7 authors, Jedd D Wolchok.
J Clin Oncol, 2015 Feb 11; 33(17). PMID: 25667295    Free PMC article.
Highly Cited.
Thymic tolerance as a key brake on autoimmunity.
Mickie Cheng, Mark S Anderson.
Nat Immunol, 2018 Jun 22; 19(7). PMID: 29925986    Free PMC article.
Review.
Insulin alleles and autoimmune regulator (AIRE) gene expression both influence insulin expression in the thymus.
Lidia Sabater, Xavier Ferrer-Francesch, +3 authors, Ricardo Pujol-Borrell.
J Autoimmun, 2005 Oct 26; 25(4). PMID: 16246524
Prevention of type I diabetes in nonobese diabetic mice by virus infection.
M B Oldstone.
Science, 1988 Jan 29; 239(4839). PMID: 3277269
Anti-thymocyte globulin (ATG) differentially depletes naïve and memory T cells and permits memory-type regulatory T cells in nonobese diabetic mice.
Chang-Qing Xia, Anna V Chernatynskaya, +6 authors, Mark A Atkinson.
BMC Immunol, 2012 Dec 15; 13. PMID: 23237483    Free PMC article.
Type 1 diabetes immunotherapy using polyclonal regulatory T cells.
Jeffrey A Bluestone, Jane H Buckner, +15 authors, Qizhi Tang.
Sci Transl Med, 2015 Nov 27; 7(315). PMID: 26606968    Free PMC article.
Highly Cited.
Cutting edge: identification of autoreactive CD4+ and CD8+ T cell subsets resistant to PD-1 pathway blockade.
Kristen E Pauken, Christine E Nelson, +10 authors, Brian T Fife.
J Immunol, 2015 Mar 15; 194(8). PMID: 25769925    Free PMC article.
Genetic and functional association of the immune signaling molecule 4-1BB (CD137/TNFRSF9) with type 1 diabetes.
Jennifer L Cannons, Giselle Chamberlain, +5 authors, Tania H Watts.
J Autoimmun, 2005 Jul 07; 25(1). PMID: 15998581
Human regulatory B cells in health and disease: therapeutic potential.
Claudia Mauri, Madhvi Menon.
J Clin Invest, 2017 Mar 02; 127(3). PMID: 28248202    Free PMC article.
Highly Cited. Review.
In CD4+ T-cell-induced diabetes, macrophages are the final effector cells that mediate islet beta-cell killing: studies from an acute model.
Boris Calderon, Anish Suri, Emil R Unanue.
Am J Pathol, 2006 Dec 07; 169(6). PMID: 17148676    Free PMC article.
Major histocompatibility complex class I molecules are required for the development of insulitis in non-obese diabetic mice.
J Katz, C Benoist, D Mathis.
Eur J Immunol, 1993 Dec 01; 23(12). PMID: 8258349
Anti-CD3 antibody induces long-term remission of overt autoimmunity in nonobese diabetic mice.
L Chatenoud, E Thervet, J Primo, J F Bach.
Proc Natl Acad Sci U S A, 1994 Jan 04; 91(1). PMID: 8278351    Free PMC article.
Highly Cited.
The defect in T-cell regulation in NOD mice is an effect on the T-cell effectors.
Anna Morena D'Alise, Vincent Auyeung, +4 authors, Diane Mathis.
Proc Natl Acad Sci U S A, 2008 Dec 17; 105(50). PMID: 19073938    Free PMC article.
Origin of regulatory T cells with known specificity for antigen.
Irina Apostolou, Adelaida Sarukhan, Ludger Klein, Harald von Boehmer.
Nat Immunol, 2002 Jun 29; 3(8). PMID: 12089509
Highly Cited.
Epitope specificity, cytokine production profile and diabetogenic activity of insulin-specific T cell clones isolated from NOD mice.
D Daniel, R G Gill, N Schloot, D Wegmann.
Eur J Immunol, 1995 Apr 01; 25(4). PMID: 7537670
Highly Cited.
Mediators and mechanisms of pancreatic beta-cell death in type 1 diabetes.
Pierre Pirot, Alessandra K Cardozo, Décio L Eizirik.
Arq Bras Endocrinol Metabol, 2008 Apr 29; 52(2). PMID: 18438526
Review.
T cell receptor signal strength in Treg and iNKT cell development demonstrated by a novel fluorescent reporter mouse.
Amy E Moran, Keli L Holzapfel, +4 authors, Kristin A Hogquist.
J Exp Med, 2011 May 25; 208(6). PMID: 21606508    Free PMC article.
Highly Cited.
Failure to censor forbidden clones of CD4 T cells in autoimmune diabetes.
Sylvie Lesage, Suzanne B Hartley, +3 authors, Christopher C Goodnow.
J Exp Med, 2002 Nov 06; 196(9). PMID: 12417628    Free PMC article.
Class I-restricted cross-presentation of exogenous self-antigens leads to deletion of autoreactive CD8(+) T cells.
C Kurts, H Kosaka, +2 authors, W R Heath.
J Exp Med, 1997 Jul 21; 186(2). PMID: 9221753    Free PMC article.
Highly Cited.
Increased synthesis of ribonucleic acids in mouse liver after treatment with a nonionic detergent.
S L Petrovic.
Biochim Biophys Acta, 1976 Jun 02; 435(1). PMID: 1276200
Defective central tolerance induction in NOD mice: genomics and genetics.
Silvia Zucchelli, Phil Holler, +3 authors, Diane Mathis.
Immunity, 2005 Mar 23; 22(3). PMID: 15780994
CTLA-4 regulates induction of anergy in vivo.
R J Greenwald, V A Boussiotis, +2 authors, A H Sharpe.
Immunity, 2001 Mar 10; 14(2). PMID: 11239447
Highly Cited.
Immunologic 'ignorance' of vascularized organ transplants in the absence of secondary lymphoid tissue.
F G Lakkis, A Arakelov, B T Konieczny, Y Inoue.
Nat Med, 2000 Jun 03; 6(6). PMID: 10835686
Highly Cited.
Susceptibility to human type 1 diabetes at IDDM2 is determined by tandem repeat variation at the insulin gene minisatellite locus.
S T Bennett, A M Lucassen, +7 authors, F Pociot.
Nat Genet, 1995 Mar 01; 9(3). PMID: 7773291
Highly Cited.
Large-scale genetic fine mapping and genotype-phenotype associations implicate polymorphism in the IL2RA region in type 1 diabetes.
Christopher E Lowe, Jason D Cooper, +10 authors, John A Todd.
Nat Genet, 2007 Aug 07; 39(9). PMID: 17676041
Highly Cited.
Role of LAG-3 in regulatory T cells.
Ching-Tai Huang, Creg J Workman, +11 authors, Dario A A Vignali.
Immunity, 2004 Oct 16; 21(4). PMID: 15485628
Highly Cited.
Differentiation of regulatory Foxp3+ T cells in the thymic cortex.
Adrian Liston, Katherine M Nutsch, +4 authors, Alexander Y Rudensky.
Proc Natl Acad Sci U S A, 2008 Aug 13; 105(33). PMID: 18695219    Free PMC article.
Highly Cited.
Bioenergetic Insufficiencies Due to Metabolic Alterations Regulated by the Inhibitory Receptor PD-1 Are an Early Driver of CD8(+) T Cell Exhaustion.
Bertram Bengsch, Andy L Johnson, +8 authors, E John Wherry.
Immunity, 2016 Aug 09; 45(2). PMID: 27496729    Free PMC article.
Highly Cited.
Safety, activity, and immune correlates of anti-PD-1 antibody in cancer.
Suzanne L Topalian, F Stephen Hodi, +27 authors, Mario Sznol.
N Engl J Med, 2012 Jun 05; 366(26). PMID: 22658127    Free PMC article.
Highly Cited.
Selective depletion of Foxp3+ regulatory T cells induces a scurfy-like disease.
Katharina Lahl, Christoph Loddenkemper, +7 authors, Tim Sparwasser.
J Exp Med, 2007 Jan 04; 204(1). PMID: 17200412    Free PMC article.
Highly Cited.
B-cells are required for the initiation of insulitis and sialitis in nonobese diabetic mice.
H Noorchashm, N Noorchashm, +3 authors, A Naji.
Diabetes, 1997 Jun 01; 46(6). PMID: 9166663
Superoxide production by macrophages and T cells is critical for the induction of autoreactivity and type 1 diabetes.
Terri C Thayer, Matthew Delano, +7 authors, Clayton E Mathews.
Diabetes, 2011 Jul 01; 60(8). PMID: 21715554    Free PMC article.
Granzyme B: a natural born killer.
Sarah J Lord, Ray V Rajotte, Gregory S Korbutt, R Chris Bleackley.
Immunol Rev, 2003 May 20; 193. PMID: 12752668
Review.
Beta cell apoptosis in T cell-mediated autoimmune diabetes.
M O Kurrer, S V Pakala, H L Hanson, J D Katz.
Proc Natl Acad Sci U S A, 1997 Jan 07; 94(1). PMID: 8990188    Free PMC article.
B lymphocyte "original sin" in the bone marrow enhances islet autoreactivity in type 1 diabetes-prone nonobese diabetic mice.
Rachel A Henry-Bonami, Jonathan M Williams, +3 authors, James W Thomas.
J Immunol, 2013 May 17; 190(12). PMID: 23677466    Free PMC article.
MHC structure and autoimmune T cell repertoire development.
W M Ridgway, C G Fathman.
Curr Opin Immunol, 2000 Jan 13; 11(6). PMID: 10631548
Review.
Both retention and recirculation contribute to long-lived regulatory T-cell accumulation in the thymus.
EnJun Yang, Tao Zou, +2 authors, Taku Kambayashi.
Eur J Immunol, 2014 Jun 05; 44(9). PMID: 24894919    Free PMC article.
The CTLA-4 gene region of chromosome 2q33 is linked to, and associated with, type 1 diabetes. Belgian Diabetes Registry.
L Nisticò, R Buzzetti, +17 authors, J A Todd.
Hum Mol Genet, 1996 Jul 01; 5(7). PMID: 8817351
Highly Cited.
Class-switched anti-insulin antibodies originate from unconventional antigen presentation in multiple lymphoid sites.
Xiaoxiao Wan, James W Thomas, Emil R Unanue.
J Exp Med, 2016 May 04; 213(6). PMID: 27139492    Free PMC article.
Induced expression of PD-1, a novel member of the immunoglobulin gene superfamily, upon programmed cell death.
Y Ishida, Y Agata, K Shibahara, T Honjo.
EMBO J, 1992 Nov 01; 11(11). PMID: 1396582    Free PMC article.
Highly Cited.
Arthritogenic self-reactive CD4+ T cells acquire an FR4hiCD73hi anergic state in the presence of Foxp3+ regulatory T cells.
Ryan J Martinez, Na Zhang, +4 authors, Daniel L Mueller.
J Immunol, 2011 Nov 30; 188(1). PMID: 22124124    Free PMC article.
Production of congenic mouse strains carrying NOD-derived diabetogenic genetic intervals: an approach for the genetic dissection of complex traits.
M A Yui, K Muralidharan, +3 authors, E K Wakeland.
Mamm Genome, 1996 May 01; 7(5). PMID: 8661724
LSECtin expressed on melanoma cells promotes tumor progression by inhibiting antitumor T-cell responses.
Feng Xu, Jing Liu, +6 authors, Fuchu He.
Cancer Res, 2014 Apr 29; 74(13). PMID: 24769443
Highly Cited.
Murine thymic selection quantified using a unique method to capture deleted T cells.
Gretta L Stritesky, Yan Xing, +5 authors, Kristin A Hogquist.
Proc Natl Acad Sci U S A, 2013 Mar 15; 110(12). PMID: 23487759    Free PMC article.
Highly Cited.
T cell tolerance by clonal elimination in the thymus.
J W Kappler, N Roehm, P Marrack.
Cell, 1987 Apr 24; 49(2). PMID: 3494522
Highly Cited.
Detection of self-reactive CD8⁺ T cells with an anergic phenotype in healthy individuals.
Yuka Maeda, Hiroyoshi Nishikawa, +8 authors, Shimon Sakaguchi.
Science, 2014 Dec 20; 346(6216). PMID: 25525252
Reduced regulatory T cell diversity in NOD mice is linked to early events in the thymus.
Cristina Ferreira, Donald Palmer, +2 authors, Julian Dyson.
J Immunol, 2014 Mar 26; 192(9). PMID: 24663675
CD28-mediated signalling co-stimulates murine T cells and prevents induction of anergy in T-cell clones.
F A Harding, J G McArthur, +2 authors, J P Allison.
Nature, 1992 Apr 16; 356(6370). PMID: 1313950
Highly Cited.
Enterovirus infection and progression from islet autoimmunity to type 1 diabetes: the Diabetes and Autoimmunity Study in the Young (DAISY).
Lars C Stene, Sami Oikarinen, +7 authors, Marian Rewers.
Diabetes, 2010 Sep 23; 59(12). PMID: 20858685    Free PMC article.
Highly Cited.
Association of a putative regulatory polymorphism in the PD-1 gene with susceptibility to type 1 diabetes.
C Nielsen, D Hansen, +2 authors, S T Lillevang.
Tissue Antigens, 2003 Nov 18; 62(6). PMID: 14617032
Foxp3 programs the development and function of CD4+CD25+ regulatory T cells.
Jason D Fontenot, Marc A Gavin, Alexander Y Rudensky.
Nat Immunol, 2003 Mar 04; 4(4). PMID: 12612578
Highly Cited.
The prevalence of enteroviral capsid protein vp1 immunostaining in pancreatic islets in human type 1 diabetes.
S J Richardson, A Willcox, +2 authors, N G Morgan.
Diabetologia, 2009 Mar 07; 52(6). PMID: 19266182
Highly Cited.
Analysis of pancreas tissue in a child positive for islet cell antibodies.
M Oikarinen, S Tauriainen, +11 authors, H Hyöty.
Diabetologia, 2008 Aug 13; 51(10). PMID: 18696046
FOXP3+ regulatory T cells in the human immune system.
Shimon Sakaguchi, Makoto Miyara, Cristina M Costantino, David A Hafler.
Nat Rev Immunol, 2010 Jun 19; 10(7). PMID: 20559327
Highly Cited. Review.
A polymorphism in PTPN2 gene is associated with an earlier onset of type 1 diabetes.
Laura Espino-Paisan, Hermenegildo de la Calle, +4 authors, Jose Luis Santiago.
Immunogenetics, 2011 Jan 20; 63(4). PMID: 21246196
Increased Effector Memory Insulin-Specific CD4+ T Cells Correlate With Insulin Autoantibodies in Patients With Recent-Onset Type 1 Diabetes.
Justin A Spanier, Nathanael L Sahli, +9 authors, Brian T Fife.
Diabetes, 2017 Aug 27; 66(12). PMID: 28842400    Free PMC article.
Expanding antigen-specific regulatory networks to treat autoimmunity.
Xavier Clemente-Casares, Jesus Blanco, +16 authors, Pere Santamaria.
Nature, 2016 Feb 18; 530(7591). PMID: 26886799
Highly Cited.
CD4(+) T cell anergy prevents autoimmunity and generates regulatory T cell precursors.
Lokesh A Kalekar, Shirdi E Schmiel, +12 authors, Daniel L Mueller.
Nat Immunol, 2016 Feb 02; 17(3). PMID: 26829766    Free PMC article.
Highly Cited.
Redemption of autoantibodies on anergic B cells by variable-region glycosylation and mutation away from self-reactivity.
Zahra Sabouri, Peter Schofield, +13 authors, Christopher C Goodnow.
Proc Natl Acad Sci U S A, 2014 May 14; 111(25). PMID: 24821781    Free PMC article.
Highly Cited.
Costimulation modulation with abatacept in patients with recent-onset type 1 diabetes: follow-up 1 year after cessation of treatment.
Tihamer Orban, Brian Bundy, +17 authors, Type 1 Diabetes TrialNet Abatacept Study Group.
Diabetes Care, 2013 Dec 04; 37(4). PMID: 24296850    Free PMC article.
Biologic activity of cytotoxic T lymphocyte-associated antigen 4 antibody blockade in previously vaccinated metastatic melanoma and ovarian carcinoma patients.
F Stephen Hodi, Martin C Mihm, +14 authors, Glenn Dranoff.
Proc Natl Acad Sci U S A, 2003 Apr 17; 100(8). PMID: 12682289    Free PMC article.
Highly Cited.
Development of lupus-like autoimmune diseases by disruption of the PD-1 gene encoding an ITIM motif-carrying immunoreceptor.
H Nishimura, M Nose, +2 authors, T Honjo.
Immunity, 1999 Sep 15; 11(2). PMID: 10485649
Highly Cited.
TLR-activated B cells suppress T cell-mediated autoimmunity.
Vicky Lampropoulou, Kai Hoehlig, +8 authors, Simon Fillatreau.
J Immunol, 2008 Mar 21; 180(7). PMID: 18354200
Highly Cited.
Regulatory B cells: origin, phenotype, and function.
Elizabeth C Rosser, Claudia Mauri.
Immunity, 2015 Apr 23; 42(4). PMID: 25902480
Highly Cited. Review.
Relationship between CD4 Regulatory T Cells and Anergy In Vivo.
Lokesh A Kalekar, Daniel L Mueller.
J Immunol, 2017 Mar 23; 198(7). PMID: 28320913    Free PMC article.
Review.
Differential Insulitic Profiles Determine the Extent of β-Cell Destruction and the Age at Onset of Type 1 Diabetes.
Pia Leete, Abby Willcox, +4 authors, Noel G Morgan.
Diabetes, 2016 Feb 10; 65(5). PMID: 26858360
Highly Cited.
Spontaneous loss of T-cell tolerance to glutamic acid decarboxylase in murine insulin-dependent diabetes.
D L Kaufman, M Clare-Salzler, +7 authors, P V Lehmann.
Nature, 1993 Nov 04; 366(6450). PMID: 7694152    Free PMC article.
Highly Cited.
Letter: HL-A antigens and diabetes mellitus.
A G Cudworth, J C Woodrow.
Lancet, 1974 Nov 09; 2(7889). PMID: 4139464
Spatiotemporal Dynamics of Insulitis in Human Type 1 Diabetes.
Kyle C A Wedgwood, Sarah J Richardson, Noel G Morgan, Krasimira Tsaneva-Atanasova.
Front Physiol, 2017 Jan 14; 7. PMID: 28082906    Free PMC article.
A Type 1 Diabetes Genetic Risk Score Predicts Progression of Islet Autoimmunity and Development of Type 1 Diabetes in Individuals at Risk.
Maria J Redondo, Susan Geyer, +9 authors, Type 1 Diabetes TrialNet Study Group.
Diabetes Care, 2018 Jul 14; 41(9). PMID: 30002199    Free PMC article.
Multiple immuno-regulatory defects in type-1 diabetes.
Anjli Kukreja, Giulia Cost, +9 authors, Noel Maclaren.
J Clin Invest, 2002 Jan 10; 109(1). PMID: 11781358    Free PMC article.
Highly Cited.
Expansion of circulating counterparts of follicular helper T cells in patients with myasthenia gravis.
Chuanming Luo, Yan Li, +5 authors, Juan Ouyang.
J Neuroimmunol, 2013 Jan 12; 256(1-2). PMID: 23305745
Murine antithymocyte globulin therapy alters disease progression in NOD mice by a time-dependent induction of immunoregulation.
Greg Simon, Matthew Parker, +18 authors, Mark A Atkinson.
Diabetes, 2007 Nov 28; 57(2). PMID: 18039815
Transgenic expression of mouse proinsulin II prevents diabetes in nonobese diabetic mice.
M B French, J Allison, +7 authors, A M Lew.
Diabetes, 1997 Jan 01; 46(1). PMID: 8971078
Tolerance is established in polyclonal CD4(+) T cells by distinct mechanisms, according to self-peptide expression patterns.
Deepali Malhotra, Jonathan L Linehan, +9 authors, Marc K Jenkins.
Nat Immunol, 2016 Jan 05; 17(2). PMID: 26726812    Free PMC article.
Highly Cited.
PD-1, but not PD-L1, expressed by islet-reactive CD4+ T cells suppresses infiltration of the pancreas during type 1 diabetes.
Kristen E Pauken, Marc K Jenkins, Miyuki Azuma, Brian T Fife.
Diabetes, 2013 Apr 03; 62(8). PMID: 23545706    Free PMC article.
Lymphoproliferative disorders with early lethality in mice deficient in Ctla-4.
P Waterhouse, J M Penninger, +6 authors, T W Mak.
Science, 1995 Nov 10; 270(5238). PMID: 7481803
Highly Cited.
Islet inflammation in human type 1 diabetes mellitus.
Noel G Morgan, Pia Leete, Alan K Foulis, Sarah J Richardson.
IUBMB Life, 2014 Dec 17; 66(11). PMID: 25504835
Review.
Transcription factors and target genes of pre-TCR signaling.
Cristina López-Rodríguez, Jose Aramburu, Rosa Berga-Bolaños.
Cell Mol Life Sci, 2015 Feb 24; 72(12). PMID: 25702312
Review.
Acceleration of diabetes in young NOD mice with a CD4+ islet-specific T cell clone.
K Haskins, M McDuffie.
Science, 1990 Sep 21; 249(4975). PMID: 2205920
Highly Cited.
Negative selection by IgM superantigen defines a B cell central tolerance compartment and reveals mutations allowing escape.
Bao Hoa Duong, Takayuki Ota, +5 authors, David Nemazee.
J Immunol, 2011 Nov 02; 187(11). PMID: 22043016    Free PMC article.
The role of CD8+ T cells in the initiation of insulin-dependent diabetes mellitus.
B Wang, A Gonzalez, C Benoist, D Mathis.
Eur J Immunol, 1996 Aug 01; 26(8). PMID: 8765018
Blockade of B7-H1 improves myeloid dendritic cell-mediated antitumor immunity.
Tyler J Curiel, Shuang Wei, +19 authors, Weiping Zou.
Nat Med, 2003 Apr 22; 9(5). PMID: 12704383
Highly Cited.
Low-Dose Anti-Thymocyte Globulin (ATG) Preserves β-Cell Function and Improves HbA1c in New-Onset Type 1 Diabetes.
Michael J Haller, Desmond A Schatz, +18 authors, Type 1 Diabetes TrialNet ATG-GCSF Study Group.
Diabetes Care, 2018 Jul 18; 41(9). PMID: 30012675    Free PMC article.
Highly Cited.
Clonal deletion of B lymphocytes in a transgenic mouse bearing anti-MHC class I antibody genes.
D A Nemazee, K Bürki.
Nature, 1989 Feb 09; 337(6207). PMID: 2783762
Highly Cited.
Characterization of T follicular helper cells in allogeneic normal pregnancy and PDL1 blockage-induced abortion.
Weihong Zeng, Zhicui Liu, +6 authors, Yi Lin.
Sci Rep, 2016 Nov 08; 6. PMID: 27819282    Free PMC article.
T cell costimulatory receptor CD28 is a primary target for PD-1-mediated inhibition.
Enfu Hui, Jeanne Cheung, +8 authors, Ronald D Vale.
Science, 2017 Mar 11; 355(6332). PMID: 28280247    Free PMC article.
Highly Cited.
PD-1 and LAG-3 inhibitory co-receptors act synergistically to prevent autoimmunity in mice.
Taku Okazaki, Il-mi Okazaki, +9 authors, Tasuku Honjo.
J Exp Med, 2011 Feb 09; 208(2). PMID: 21300912    Free PMC article.
CTLA-4 control over Foxp3+ regulatory T cell function.
Kajsa Wing, Yasushi Onishi, +5 authors, Shimon Sakaguchi.
Science, 2008 Oct 11; 322(5899). PMID: 18845758
Highly Cited.
Disruption of a new forkhead/winged-helix protein, scurfin, results in the fatal lymphoproliferative disorder of the scurfy mouse.
M E Brunkow, E W Jeffery, +7 authors, F Ramsdell.
Nat Genet, 2001 Jan 04; 27(1). PMID: 11138001
Highly Cited.
The Role of NOD Mice in Type 1 Diabetes Research: Lessons from the Past and Recommendations for the Future.
Yi-Guang Chen, Clayton E Mathews, John P Driver.
Front Endocrinol (Lausanne), 2018 Mar 13; 9. PMID: 29527189    Free PMC article.
Receptor editing in self-reactive bone marrow B cells.
S L Tiegs, D M Russell, D Nemazee.
J Exp Med, 1993 Apr 01; 177(4). PMID: 8459201    Free PMC article.
Highly Cited.
Insulin expression in human thymus is modulated by INS VNTR alleles at the IDDM2 locus.
P Vafiadis, S T Bennett, +6 authors, C Polychronakos.
Nat Genet, 1997 Mar 01; 15(3). PMID: 9054944
Highly Cited.
Regulatory T cells and immune tolerance.
Shimon Sakaguchi, Tomoyuki Yamaguchi, Takashi Nomura, Masahiro Ono.
Cell, 2008 May 31; 133(5). PMID: 18510923
Highly Cited. Review.
Regulation of the immune response by antigen.
R M Zinkernagel, H Hengartner.
Science, 2001 Jul 14; 293(5528). PMID: 11452115
Review.
Enterovirus infection and type 1 diabetes mellitus: systematic review and meta-analysis of observational molecular studies.
Wing-Chi G Yeung, William D Rawlinson, Maria E Craig.
BMJ, 2011 Feb 05; 342. PMID: 21292721    Free PMC article.
Highly Cited. Systematic Review.
LAG-3 regulates CD8+ T cell accumulation and effector function in murine self- and tumor-tolerance systems.
Joseph F Grosso, Cristin C Kelleher, +10 authors, Charles G Drake.
J Clin Invest, 2007 Oct 13; 117(11). PMID: 17932562    Free PMC article.
Highly Cited.
Clinical blockade of PD1 and LAG3--potential mechanisms of action.
Linh T Nguyen, Pamela S Ohashi.
Nat Rev Immunol, 2014 Dec 24; 15(1). PMID: 25534622
Highly Cited. Review.
Loss of anergic B cells in prediabetic and new-onset type 1 diabetic patients.
Mia J Smith, Thomas A Packard, +8 authors, John C Cambier.
Diabetes, 2014 Dec 20; 64(5). PMID: 25524915    Free PMC article.
Germinal centers.
Gabriel D Victora, Michel C Nussenzweig.
Annu Rev Immunol, 2012 Jan 10; 30. PMID: 22224772
Highly Cited. Review.
Deletional tolerance mediated by extrathymic Aire-expressing cells.
James M Gardner, Jason J Devoss, +8 authors, Mark S Anderson.
Science, 2008 Aug 09; 321(5890). PMID: 18687966    Free PMC article.
Highly Cited.
HLA-DQ beta gene contributes to susceptibility and resistance to insulin-dependent diabetes mellitus.
J A Todd, J I Bell, H O McDevitt.
Nature, 1987 Oct 15; 329(6140). PMID: 3309680
Highly Cited.
CD4+ T cell help impairs CD8+ T cell deletion induced by cross-presentation of self-antigens and favors autoimmunity.
C Kurts, F R Carbone, +4 authors, J F Miller.
J Exp Med, 1998 Feb 12; 186(12). PMID: 9396776    Free PMC article.
A single course of anti-CD3 monoclonal antibody hOKT3gamma1(Ala-Ala) results in improvement in C-peptide responses and clinical parameters for at least 2 years after onset of type 1 diabetes.
Kevan C Herold, Stephen E Gitelman, +7 authors, Jeffrey A Bluestone.
Diabetes, 2005 May 28; 54(6). PMID: 15919798    Free PMC article.
Highly Cited.
Acceleration of type 1 diabetes by a coxsackievirus infection requires a preexisting critical mass of autoreactive T-cells in pancreatic islets.
D V Serreze, E W Ottendorfer, +2 authors, M A Atkinson.
Diabetes, 2000 Jul 25; 49(5). PMID: 10905477
Interleukin-10 produced by B cells is crucial for the suppression of Th17/Th1 responses, induction of T regulatory type 1 cells and reduction of collagen-induced arthritis.
Natalie A Carter, Elizabeth C Rosser, Claudia Mauri.
Arthritis Res Ther, 2012 Feb 10; 14(1). PMID: 22315945    Free PMC article.
Highly Cited.
Prevention of autoimmune insulitis by expression of I-E molecules in NOD mice.
H Nishimoto, H Kikutani, K Yamamura, T Kishimoto.
Nature, 1987 Jul 05; 328(6129). PMID: 3302721
Highly Cited.
Essential role of the E3 ubiquitin ligase Cbl-b in T cell anergy induction.
Myung-Shin Jeon, Alex Atfield, +16 authors, Josef M Penninger.
Immunity, 2004 Aug 17; 21(2). PMID: 15308098
Highly Cited.
B-cell cross-presentation of autologous antigen precipitates diabetes.
Eliana Mariño, Bernice Tan, +2 authors, Shane T Grey.
Diabetes, 2012 Jul 26; 61(11). PMID: 22829452    Free PMC article.
LAG-3 inhibits the activation of CD4+ T cells that recognize stable pMHCII through its conformation-dependent recognition of pMHCII.
Takumi Maruhashi, Il-Mi Okazaki, +4 authors, Taku Okazaki.
Nat Immunol, 2018 Oct 24; 19(12). PMID: 30349037
International Workshop on Lessons From Animal Models for Human Type 1 Diabetes: identification of insulin but not glutamic acid decarboxylase or IA-2 as specific autoantigens of humoral autoimmunity in nonobese diabetic mice.
E Bonifacio, M Atkinson, +4 authors, B Singh.
Diabetes, 2001 Oct 27; 50(11). PMID: 11679421
Review.
Lymphocyte Activation Gene-3 (LAG-3) negatively regulates environmentally-induced autoimmunity.
Vibha Jha, Creg J Workman, +4 authors, Marc Monestier.
PLoS One, 2014 Aug 15; 9(8). PMID: 25122007    Free PMC article.
Overcoming T cell exhaustion in infection and cancer.
Kristen E Pauken, E John Wherry.
Trends Immunol, 2015 Mar 24; 36(4). PMID: 25797516    Free PMC article.
Highly Cited. Review.
X-linked neonatal diabetes mellitus, enteropathy and endocrinopathy syndrome is the human equivalent of mouse scurfy.
R S Wildin, F Ramsdell, +13 authors, M E Brunkow.
Nat Genet, 2001 Jan 04; 27(1). PMID: 11137992
Highly Cited.
Thymic negative selection is functional in NOD mice.
Michael Mingueneau, Wenyu Jiang, +2 authors, Christophe Benoist.
J Exp Med, 2012 Feb 15; 209(3). PMID: 22329992    Free PMC article.
Enterovirus infection as a risk factor for beta-cell autoimmunity in a prospectively observed birth cohort: the Finnish Diabetes Prediction and Prevention Study.
M Lönnrot, K Korpela, +8 authors, H Hyöty.
Diabetes, 2000 Aug 03; 49(8). PMID: 10923631
Thymic selection of CD4+CD25+ regulatory T cells induced by an agonist self-peptide.
M S Jordan, A Boesteanu, +5 authors, A J Caton.
Nat Immunol, 2001 Mar 29; 2(4). PMID: 11276200
Highly Cited.
Molecular signature of CD8+ T cell exhaustion during chronic viral infection.
E John Wherry, Sang-Jun Ha, +7 authors, Rafi Ahmed.
Immunity, 2007 Oct 24; 27(4). PMID: 17950003
Highly Cited.
Heterogeneity and Lobularity of Pancreatic Pathology in Type 1 Diabetes during the Prediabetic Phase.
Teresa Rodriguez-Calvo, Jessica S Suwandi, +4 authors, Matthias G von Herrath.
J Histochem Cytochem, 2015 Jul 29; 63(8). PMID: 26216138    Free PMC article.
Teplizumab (anti-CD3 mAb) treatment preserves C-peptide responses in patients with new-onset type 1 diabetes in a randomized controlled trial: metabolic and immunologic features at baseline identify a subgroup of responders.
Kevan C Herold, Stephen E Gitelman, +11 authors, AbATE Study Team.
Diabetes, 2013 Jul 10; 62(11). PMID: 23835333    Free PMC article.
Highly Cited.
Prime role for an insulin epitope in the development of type 1 diabetes in NOD mice.
Maki Nakayama, Norio Abiru, +8 authors, George S Eisenbarth.
Nature, 2005 May 13; 435(7039). PMID: 15889095    Free PMC article.
Highly Cited.
CD8 T cell ignorance or tolerance to islet antigens depends on antigen dose.
C Kurts, R M Sutherland, +6 authors, W R Heath.
Proc Natl Acad Sci U S A, 1999 Oct 27; 96(22). PMID: 10535986    Free PMC article.
PD-1 gene haplotype is associated with the development of type 1 diabetes mellitus in Japanese children.
Ronghua Ni, Kenji Ihara, +4 authors, Toshiro Hara.
Hum Genet, 2007 Jan 05; 121(2). PMID: 17203303
Thymus-Derived Regulatory T Cells Are Positively Selected on Natural Self-Antigen through Cognate Interactions of High Functional Avidity.
Elisa Kieback, Ellen Hilgenberg, +13 authors, Simon Fillatreau.
Immunity, 2016 May 19; 44(5). PMID: 27192577
Cytokine-secreting follicular T cells shape the antibody repertoire.
R Lee Reinhardt, Hong-Erh Liang, Richard M Locksley.
Nat Immunol, 2009 Mar 03; 10(4). PMID: 19252490    Free PMC article.
Highly Cited.
CD40 on NOD CD4 T cells contributes to their activation and pathogenicity.
Rocky L Baker, David H Wagner, Kathryn Haskins.
J Autoimmun, 2008 Oct 28; 31(4). PMID: 18951762
PD-1 regulates self-reactive CD8+ T cell responses to antigen in lymph nodes and tissues.
Mary E Keir, Gordon J Freeman, Arlene H Sharpe.
J Immunol, 2007 Oct 04; 179(8). PMID: 17911591
Prevalence of type 1 and type 2 diabetes among children and adolescents from 2001 to 2009.
Dana Dabelea, Elizabeth J Mayer-Davis, +15 authors, SEARCH for Diabetes in Youth Study.
JAMA, 2014 May 06; 311(17). PMID: 24794371    Free PMC article.
Highly Cited.
Low-dose otelixizumab anti-CD3 monoclonal antibody DEFEND-1 study: results of the randomized phase III study in recent-onset human type 1 diabetes.
Ronnie Aronson, Peter A Gottlieb, +5 authors, DEFEND Investigator Group.
Diabetes Care, 2014 Jul 12; 37(10). PMID: 25011949    Free PMC article.
Visualization of peptide-specific T cell immunity and peripheral tolerance induction in vivo.
E R Kearney, K A Pape, D Y Loh, M K Jenkins.
Immunity, 1994 Jul 01; 1(4). PMID: 7889419
Highly Cited.
PD-1 Controls Follicular T Helper Cell Positioning and Function.
Jingwen Shi, Shiyue Hou, +3 authors, Hai Qi.
Immunity, 2018 Aug 05; 49(2). PMID: 30076099    Free PMC article.
Highly Cited.
Regulatory B cells control T-cell autoimmunity through IL-21-dependent cognate interactions.
Ayumi Yoshizaki, Tomomitsu Miyagaki, +7 authors, Thomas F Tedder.
Nature, 2012 Oct 16; 491(7423). PMID: 23064231    Free PMC article.
Highly Cited.
The interaction properties of costimulatory molecules revisited.
Alison V Collins, Douglas W Brodie, +6 authors, Simon J Davis.
Immunity, 2002 Aug 28; 17(2). PMID: 12196291
Highly Cited.
The programmed death-1 (PD-1) pathway regulates autoimmune diabetes in nonobese diabetic (NOD) mice.
Mohammed Javeed I Ansari, Alan D Salama, +9 authors, Mohamed H Sayegh.
J Exp Med, 2003 Jul 09; 198(1). PMID: 12847137    Free PMC article.
Highly Cited.
The development and function of regulatory B cells expressing IL-10 (B10 cells) requires antigen receptor diversity and TLR signals.
Koichi Yanaba, Jean-David Bouaziz, +2 authors, Thomas F Tedder.
J Immunol, 2009 Jun 06; 182(12). PMID: 19494269    Free PMC article.
Highly Cited.
TCR affinity and tolerance mechanisms converge to shape T cell diabetogenic potential.
Maria Bettini, Lori Blanchfield, +7 authors, Dario A A Vignali.
J Immunol, 2014 Jun 20; 193(2). PMID: 24943217    Free PMC article.
Antibodies against insulin measured by electrochemiluminescence predicts insulitis severity and disease onset in non-obese diabetic mice and can distinguish human type 1 diabetes status.
Bernice Lo, Austin D E Swafford, +12 authors, Michael J Lenardo.
J Transl Med, 2011 Nov 30; 9. PMID: 22123298    Free PMC article.
Inhibition of increased circulating Tfh cell by anti-CD20 monoclonal antibody in patients with type 1 diabetes.
Xinyu Xu, Yun Shi, +7 authors, Tao Yang.
PLoS One, 2013 Nov 28; 8(11). PMID: 24278195    Free PMC article.
The receptor PD-1 controls follicular regulatory T cells in the lymph nodes and blood.
Peter T Sage, Loise M Francisco, Christopher V Carman, Arlene H Sharpe.
Nat Immunol, 2012 Dec 18; 14(2). PMID: 23242415    Free PMC article.
Highly Cited.
Collagen antibody-induced arthritis in mice: development of a new arthritogenic 5-clone cocktail of monoclonal anti-type II collagen antibodies.
Pilaiwanwadee Hutamekalin, Takayuki Saito, +5 authors, Shin Yoshino.
J Immunol Methods, 2009 Mar 31; 343(1). PMID: 19330909
Pinpointing when T cell costimulatory receptor CTLA-4 must be engaged to dampen diabetogenic T cells.
F Luhder, C Chambers, +2 authors, D Mathis.
Proc Natl Acad Sci U S A, 2000 Oct 18; 97(22). PMID: 11035773    Free PMC article.
Protein kinase C-η controls CTLA-4-mediated regulatory T cell function.
Kok-Fai Kong, Guo Fu, +10 authors, Amnon Altman.
Nat Immunol, 2014 Apr 08; 15(5). PMID: 24705298    Free PMC article.
Highly Cited.
Regulatory T cells prevent catastrophic autoimmunity throughout the lifespan of mice.
Jeong M Kim, Jeffrey P Rasmussen, Alexander Y Rudensky.
Nat Immunol, 2006 Dec 01; 8(2). PMID: 17136045
Highly Cited.
Enhanced induction of antitumor T-cell responses by cytotoxic T lymphocyte-associated molecule-4 blockade: the effect is manifested only at the restricted tumor-bearing stages.
Y F Yang, J P Zou, +6 authors, T Hamaoka.
Cancer Res, 1997 Oct 27; 57(18). PMID: 9307290
Expansion of circulating T cells resembling follicular helper T cells is a fixed phenotype that identifies a subset of severe systemic lupus erythematosus.
Nicholas Simpson, Paul A Gatenby, +10 authors, Matthew C Cook.
Arthritis Rheum, 2009 Dec 30; 62(1). PMID: 20039395
Highly Cited.
Central tolerance spares the private high-avidity CD4(+) T-cell repertoire specific for an islet antigen in NOD mice.
Laurent Serre, Nicolas Fazilleau, Sylvie Guerder.
Eur J Immunol, 2015 Apr 18; 45(7). PMID: 25884569
Enhanced pathogenicity of diabetogenic T cells escaping a non-MHC gene-controlled near death experience.
Caroline-Morgane Choisy-Rossi, Thomas M Holl, +2 authors, David V Serreze.
J Immunol, 2004 Sep 10; 173(6). PMID: 15356126
The insulin gene is transcribed in the human thymus and transcription levels correlated with allelic variation at the INS VNTR-IDDM2 susceptibility locus for type 1 diabetes.
A Pugliese, M Zeller, +7 authors, D D Patel.
Nat Genet, 1997 Mar 01; 15(3). PMID: 9054945
Highly Cited.
T Helper Cell Differentiation, Heterogeneity, and Plasticity.
Jinfang Zhu.
Cold Spring Harb Perspect Biol, 2017 Aug 30; 10(10). PMID: 28847903    Free PMC article.
Review.
An accessory cell-derived costimulatory signal acts independently of protein kinase C activation to allow T cell proliferation and prevent the induction of unresponsiveness.
D L Mueller, M K Jenkins, R H Schwartz.
J Immunol, 1989 Apr 15; 142(8). PMID: 2522963
Autoimmune diabetes in NOD mouse is L3T4 T-lymphocyte dependent.
Y Wang, L Hao, R G Gill, K J Lafferty.
Diabetes, 1987 Apr 01; 36(4). PMID: 3102301
Galectin-3 Shapes Antitumor Immune Responses by Suppressing CD8+ T Cells via LAG-3 and Inhibiting Expansion of Plasmacytoid Dendritic Cells.
Theodore Kouo, Lanqing Huang, +4 authors, Elizabeth Jaffee.
Cancer Immunol Res, 2015 Feb 19; 3(4). PMID: 25691328    Free PMC article.
Highly Cited.
Depleting anti-CD4 monoclonal antibody cures new-onset diabetes, prevents recurrent autoimmune diabetes, and delays allograft rejection in nonobese diabetic mice.
Leila Makhlouf, Shane T Grey, +5 authors, Mohamed H Sayegh.
Transplantation, 2004 Apr 17; 77(7). PMID: 15087759
A granulocyte-macrophage colony-stimulating factor and interleukin-15 fusokine induces a regulatory B cell population with immune suppressive properties.
Moutih Rafei, Jeremy Hsieh, +7 authors, Jacques Galipeau.
Nat Med, 2009 Aug 12; 15(9). PMID: 19668193
Susceptibility to type 1 (insulin-dependent) diabetes mellitus in Spanish patients correlates quantitatively with expression of HLA-DQ alpha Arg 52 and HLA-DQ beta non-Asp 57 alleles.
M D Gutierrez-Lopez, S Bertera, +4 authors, M Serrano-Rios.
Diabetologia, 1992 Jun 01; 35(6). PMID: 1612233
Germinal centre frequency is decreased in pancreatic lymph nodes from individuals with recent-onset type 1 diabetes.
Abby Willcox, Sarah J Richardson, +3 authors, Kathleen M Gillespie.
Diabetologia, 2017 Feb 19; 60(7). PMID: 28213757    Free PMC article.
Through regulation of TCR expression levels, an Idd7 region gene(s) interactively contributes to the impaired thymic deletion of autoreactive diabetogenic CD8+ T cells in nonobese diabetic mice.
David V Serreze, Caroline Morgane Choisy-Rossi, +9 authors, Michele P Marron.
J Immunol, 2008 Feb 23; 180(5). PMID: 18292549
B cell specificity contributes to the outcome of diabetes in nonobese diabetic mice.
C Hulbert, B Riseili, M Rojas, J W Thomas.
J Immunol, 2001 Nov 08; 167(10). PMID: 11698422
Tumor-Specific T Cell Dysfunction Is a Dynamic Antigen-Driven Differentiation Program Initiated Early during Tumorigenesis.
Andrea Schietinger, Mary Philip, +10 authors, Philip D Greenberg.
Immunity, 2016 Aug 16; 45(2). PMID: 27521269    Free PMC article.
Highly Cited.
Toward testing the hypothesis that group B coxsackieviruses (CVB) trigger insulin-dependent diabetes: inoculating nonobese diabetic mice with CVB markedly lowers diabetes incidence.
S Tracy, K M Drescher, +6 authors, J S Leser.
J Virol, 2002 Nov 05; 76(23). PMID: 12414951    Free PMC article.
B7/CD28 costimulation is essential for the homeostasis of the CD4+CD25+ immunoregulatory T cells that control autoimmune diabetes.
B Salomon, D J Lenschow, +4 authors, J A Bluestone.
Immunity, 2000 May 05; 12(4). PMID: 10795741
Highly Cited.
Non-obese diabetic mice select a low-diversity repertoire of natural regulatory T cells.
Cristina Ferreira, Yogesh Singh, +3 authors, Julian Dyson.
Proc Natl Acad Sci U S A, 2009 Apr 11; 106(20). PMID: 19359477    Free PMC article.
Breeding of a non-obese, diabetic strain of mice.
S Makino, K Kunimoto, +3 authors, Y Tochino.
Jikken Dobutsu, 1980 Jan 01; 29(1). PMID: 6995140
Highly Cited.
T follicular regulatory cells in the regulation of B cell responses.
Peter T Sage, Arlene H Sharpe.
Trends Immunol, 2015 Jun 21; 36(7). PMID: 26091728    Free PMC article.
Highly Cited. Review.
Autoimmune diabetes onset results from qualitative rather than quantitative age-dependent changes in pathogenic T-cells.
Sylvaine You, Mériam Belghith, +7 authors, Lucienne Chatenoud.
Diabetes, 2005 Apr 28; 54(5). PMID: 15855328
Rituximab, B-lymphocyte depletion, and preservation of beta-cell function.
Mark D Pescovitz, Carla J Greenbaum, +15 authors, Type 1 Diabetes TrialNet Anti-CD20 Study Group.
N Engl J Med, 2009 Nov 27; 361(22). PMID: 19940299    Free PMC article.
Highly Cited.
Promiscuous gene expression in thymic epithelial cells is regulated at multiple levels.
Jens Derbinski, Jana Gäbler, +6 authors, Bruno Kyewski.
J Exp Med, 2005 Jun 29; 202(1). PMID: 15983066    Free PMC article.
Highly Cited.
IL-35-producing B cells are critical regulators of immunity during autoimmune and infectious diseases.
Ping Shen, Toralf Roch, +28 authors, Simon Fillatreau.
Nature, 2014 Feb 28; 507(7492). PMID: 24572363    Free PMC article.
Highly Cited.
Major histocompatibility complex class I-restricted T cells are required for all but the end stages of diabetes development in nonobese diabetic mice and use a prevalent T cell receptor alpha chain gene rearrangement.
T P DiLorenzo, R T Graser, +5 authors, D V Serreze.
Proc Natl Acad Sci U S A, 1998 Oct 15; 95(21). PMID: 9770521    Free PMC article.
Widespread expression of an autoantigen-GAD65 transgene does not tolerize non-obese diabetic mice and can exacerbate disease.
L Geng, M Solimena, +2 authors, A C Hayday.
Proc Natl Acad Sci U S A, 1998 Aug 26; 95(17). PMID: 9707599    Free PMC article.
Premature TCR alpha beta expression and signaling in early thymocytes impair thymocyte expansion and partially block their development.
H D Lacorazza, C Tucek-Szabo, +2 authors, J Nikolich-Zugich.
J Immunol, 2001 Feb 24; 166(5). PMID: 11207271
Measuring the genetic contribution of a single locus to a multilocus disease.
J I Rotter, E M Landaw.
Clin Genet, 1984 Dec 01; 26(6). PMID: 6541983
The inhibitory receptor PD-1 regulates IgA selection and bacterial composition in the gut.
Shimpei Kawamoto, Thinh H Tran, +5 authors, Sidonia Fagarasan.
Science, 2012 Apr 28; 336(6080). PMID: 22539724
Highly Cited.
Dynamics of pathogenic and suppressor T cells in autoimmune diabetes development.
Silvia Gregori, Nadia Giarratana, Simona Smiroldo, Luciano Adorini.
J Immunol, 2003 Oct 08; 171(8). PMID: 14530324
Atypical motifs in the cytoplasmic region of the inhibitory immune co-receptor LAG-3 inhibit T cell activation.
Takeo K Maeda, Daisuke Sugiura, +2 authors, Taku Okazaki.
J Biol Chem, 2019 Feb 15; 294(15). PMID: 30760527    Free PMC article.
Perforin facilitates beta cell killing and regulates autoreactive CD8+ T-cell responses to antigen in mouse models of type 1 diabetes.
Prerak Trivedi, Kate L Graham, +4 authors, Helen E Thomas.
Immunol Cell Biol, 2015 Oct 09; 94(4). PMID: 26446877
Central role of defective interleukin-2 production in the triggering of islet autoimmune destruction.
Qizhi Tang, Jason Y Adams, +6 authors, Jeffrey A Bluestone.
Immunity, 2008 May 13; 28(5). PMID: 18468463    Free PMC article.
Highly Cited.
RS rearrangement frequency as a marker of receptor editing in lupus and type 1 diabetes.
Anil K Panigrahi, Noah G Goodman, +3 authors, Eline T Luning Prak.
J Exp Med, 2008 Dec 17; 205(13). PMID: 19075293    Free PMC article.
GAD65 is recognized by T-cells, but not by antibodies from NOD-mice.
S Bieg, J Seissler, +2 authors, W A Scherbaum.
Autoimmunity, 1994 Jan 01; 17(3). PMID: 7948603
PD-L1-driven tolerance protects neurogenin3-induced islet neogenesis to reverse established type 1 diabetes in NOD mice.
Rongying Li, Jeongkyung Lee, +12 authors, Vijay Yechoor.
Diabetes, 2014 Oct 22; 64(2). PMID: 25332429    Free PMC article.
Anti-CD3 monoclonal antibody in new-onset type 1 diabetes mellitus.
Kevan C Herold, William Hagopian, +8 authors, Jeffrey A Bluestone.
N Engl J Med, 2002 May 31; 346(22). PMID: 12037148
Highly Cited.
Insulin needs after CD3-antibody therapy in new-onset type 1 diabetes.
Bart Keymeulen, Evy Vandemeulebroucke, +22 authors, Lucienne Chatenoud.
N Engl J Med, 2005 Jun 24; 352(25). PMID: 15972866
Highly Cited.
Teplizumab for treatment of type 1 diabetes (Protégé study): 1-year results from a randomised, placebo-controlled trial.
Nicole Sherry, William Hagopian, +17 authors, Protégé Trial Investigators.
Lancet, 2011 Jul 02; 378(9790). PMID: 21719095    Free PMC article.
Highly Cited.
Aspartic acid at position 57 of the HLA-DQ beta chain protects against type I diabetes: a family study.
P A Morel, J S Dorman, +2 authors, M Trucco.
Proc Natl Acad Sci U S A, 1988 Nov 01; 85(21). PMID: 3186714    Free PMC article.
Highly Cited.
Dendritic Cell PD-L1 Limits Autoimmunity and Follicular T Cell Differentiation and Function.
Peter T Sage, Frank A Schildberg, +3 authors, Arlene H Sharpe.
J Immunol, 2018 Mar 14; 200(8). PMID: 29531164    Free PMC article.
Highly Cited.
Deletion of CTLA-4 on regulatory T cells during adulthood leads to resistance to autoimmunity.
Alison M Paterson, Scott B Lovitch, +9 authors, Arlene H Sharpe.
J Exp Med, 2015 Sep 16; 212(10). PMID: 26371185    Free PMC article.
Highly Cited.
B lymphocytes are critical antigen-presenting cells for the initiation of T cell-mediated autoimmune diabetes in nonobese diabetic mice.
D V Serreze, S A Fleming, +3 authors, R M Tisch.
J Immunol, 1998 Oct 21; 161(8). PMID: 9780157
Highly Cited.
Expanded T cells from pancreatic lymph nodes of type 1 diabetic subjects recognize an insulin epitope.
Sally C Kent, Yahua Chen, +5 authors, David A Hafler.
Nature, 2005 May 13; 435(7039). PMID: 15889096
Highly Cited.
LAG-3 Inhibitory Receptor Expression Identifies Immunosuppressive Natural Regulatory Plasma Cells.
Andreia C Lino, Van Duc Dang, +27 authors, Simon Fillatreau.
Immunity, 2018 Jul 15; 49(1). PMID: 30005826    Free PMC article.
Highly Cited.
Rescue of exhausted CD8 T cells by PD-1-targeted therapies is CD28-dependent.
Alice O Kamphorst, Andreas Wieland, +17 authors, Rafi Ahmed.
Science, 2017 Mar 11; 355(6332). PMID: 28280249    Free PMC article.
Highly Cited.
Efficacy and safety of low-dose otelixizumab anti-CD3 monoclonal antibody in preserving C-peptide secretion in adolescent type 1 diabetes: DEFEND-2, a randomized, placebo-controlled, double-blind, multi-centre study.
P Ambery, T W Donner, +3 authors, C M Dayan.
Diabet Med, 2013 Nov 19; 31(4). PMID: 24236828
An autoimmune disease, APECED, caused by mutations in a novel gene featuring two PHD-type zinc-finger domains.
Finnish-German APECED Consortium.
Nat Genet, 1997 Dec 17; 17(4). PMID: 9398840
Highly Cited.
Systemic inflammation in progressive multiple sclerosis involves follicular T-helper, Th17- and activated B-cells and correlates with progression.
Jeppe Romme Christensen, Lars Börnsen, +5 authors, Finn Sellebjerg.
PLoS One, 2013 Mar 08; 8(3). PMID: 23469245    Free PMC article.
Highly Cited.
Treg cells-the next frontier of cell therapy.
Jeffrey A Bluestone, Qizhi Tang.
Science, 2018 Oct 13; 362(6411). PMID: 30309932
Highly Cited.
The effect of infections on susceptibility to autoimmune and allergic diseases.
Jean-Francois Bach.
N Engl J Med, 2002 Sep 20; 347(12). PMID: 12239261
Highly Cited. Review.
Elimination from peripheral lymphoid tissues of self-reactive B lymphocytes recognizing membrane-bound antigens.
S B Hartley, J Crosbie, +3 authors, C C Goodnow.
Nature, 1991 Oct 24; 353(6346). PMID: 1944535
Highly Cited.
Signal 3 determines tolerance versus full activation of naive CD8 T cells: dissociating proliferation and development of effector function.
Julie M Curtsinger, Debra C Lins, Matthew F Mescher.
J Exp Med, 2003 May 07; 197(9). PMID: 12732656    Free PMC article.
Highly Cited.
Immune inhibitory molecules LAG-3 and PD-1 synergistically regulate T-cell function to promote tumoral immune escape.
Seng-Ryong Woo, Meghan E Turnis, +18 authors, Dario A A Vignali.
Cancer Res, 2011 Dec 22; 72(4). PMID: 22186141    Free PMC article.
Highly Cited.
Collateral Damage: Insulin-Dependent Diabetes Induced With Checkpoint Inhibitors.
Angeliki M Stamatouli, Zoe Quandt, +11 authors, Kevan C Herold.
Diabetes, 2018 Jun 26; 67(8). PMID: 29937434    Free PMC article.
Highly Cited. Review.
Four-year metabolic outcome of a randomised controlled CD3-antibody trial in recent-onset type 1 diabetic patients depends on their age and baseline residual beta cell mass.
B Keymeulen, M Walter, +12 authors, D Pipeleers.
Diabetologia, 2010 Mar 13; 53(4). PMID: 20225393
Highly Cited.
Interferon-gamma drives programmed death-ligand 1 expression on islet β cells to limit T cell function during autoimmune diabetes.
Kevin C Osum, Adam L Burrack, +8 authors, Brian T Fife.
Sci Rep, 2018 May 31; 8(1). PMID: 29844327    Free PMC article.
A Hypermorphic Nfkbid Allele Contributes to Impaired Thymic Deletion of Autoreactive Diabetogenic CD8+ T Cells in NOD Mice.
Maximiliano Presa, Jeremy J Racine, +10 authors, David V Serreze.
J Immunol, 2018 Aug 22; 201(7). PMID: 30127089    Free PMC article.
Extrathymic Aire-expressing cells are a distinct bone marrow-derived population that induce functional inactivation of CD4⁺ T cells.
James M Gardner, Todd C Metzger, +10 authors, Mark S Anderson.
Immunity, 2013 Sep 03; 39(3). PMID: 23993652    Free PMC article.
Differential effects of anti-B7-1 and anti-B7-2 monoclonal antibody treatment on the development of diabetes in the nonobese diabetic mouse.
D J Lenschow, S C Ho, +5 authors, J A Bluestone.
J Exp Med, 1995 Mar 01; 181(3). PMID: 7532678    Free PMC article.
Highly Cited.
T-cell exhaustion, co-stimulation and clinical outcome in autoimmunity and infection.
Eoin F McKinney, James C Lee, +2 authors, Kenneth G C Smith.
Nature, 2015 Jul 01; 523(7562). PMID: 26123020    Free PMC article.
Highly Cited.
Defective transcription of the IL-2 gene is associated with impaired expression of c-Fos, FosB, and JunB in anergic T helper 1 cells.
A Mondino, C D Whaley, +3 authors, D L Mueller.
J Immunol, 1996 Sep 01; 157(5). PMID: 8757326
Interactions between PD-1 and PD-L1 promote tolerance by blocking the TCR-induced stop signal.
Brian T Fife, Kristen E Pauken, +6 authors, Jeffrey A Bluestone.
Nat Immunol, 2009 Sep 29; 10(11). PMID: 19783989    Free PMC article.
Highly Cited.
Directing T cell fate: How thymic antigen presenting cells coordinate thymocyte selection.
Elise R Breed, S Thera Lee, Kristin A Hogquist.
Semin Cell Dev Biol, 2017 Aug 13; 84. PMID: 28800929    Free PMC article.
Review.
A T-cell functional phenotype common among autoimmune-prone rodent strains.
J Lang, D Bellgrau.
Scand J Immunol, 2002 May 25; 55(6). PMID: 12028557
Age of islet autoantibody appearance and mean levels of insulin, but not GAD or IA-2 autoantibodies, predict age of diagnosis of type 1 diabetes: diabetes autoimmunity study in the young.
Andrea K Steck, Kelly Johnson, +5 authors, Marian J Rewers.
Diabetes Care, 2011 May 13; 34(6). PMID: 21562325    Free PMC article.
Highly Cited.
B cell regulation of CD4+CD25+ T regulatory cells and IL-10 via B7 is essential for recovery from experimental autoimmune encephalomyelitis.
Monica K Mann, Katarzyna Maresz, +2 authors, Bonnie N Dittel.
J Immunol, 2007 Mar 07; 178(6). PMID: 17339439
Highly Cited.
Cutting Edge: Nonobese Diabetic Mice Deficient in Chromogranin A Are Protected from Autoimmune Diabetes.
Rocky L Baker, Brenda Bradley, +5 authors, Kathryn Haskins.
J Immunol, 2015 Nov 27; 196(1). PMID: 26608914    Free PMC article.
Prevalent CD8(+) T cell response against one peptide/MHC complex in autoimmune diabetes.
B Anderson, B J Park, +2 authors, P Santamaria.
Proc Natl Acad Sci U S A, 1999 Aug 04; 96(16). PMID: 10430939    Free PMC article.
Mouse pancreatic beta cells express MHC class II and stimulate CD4(+) T cells to proliferate.
Yuxing Zhao, Nicholas A Scott, +6 authors, Helen E Thomas.
Eur J Immunol, 2015 May 12; 45(9). PMID: 25959978
Mechanisms of PDL1-mediated regulation of autoimmune diabetes.
Indira Guleria, Melanie Gubbels Bupp, +11 authors, Mohamed H Sayegh.
Clin Immunol, 2007 Jul 14; 125(1). PMID: 17627890
Abnormal T cell selection on nod thymic epithelium is sufficient to induce autoimmune manifestations in C57BL/6 athymic nude mice.
V Thomas-Vaslin, D Damotte, +3 authors, J Salaün.
Proc Natl Acad Sci U S A, 1997 Apr 29; 94(9). PMID: 9114036    Free PMC article.
Fc-dependent depletion of tumor-infiltrating regulatory T cells co-defines the efficacy of anti-CTLA-4 therapy against melanoma.
Tyler R Simpson, Fubin Li, +11 authors, Sergio A Quezada.
J Exp Med, 2013 Jul 31; 210(9). PMID: 23897981    Free PMC article.
Highly Cited.
Pathogenic Citrulline-Multispecific B Cell Receptor Clades in Rheumatoid Arthritis.
Philip J Titcombe, Gustaf Wigerblad, +16 authors, Daniel L Mueller.
Arthritis Rheumatol, 2018 Jun 22; 70(12). PMID: 29927106    Free PMC article.
Concordance for islet autoimmunity among monozygotic twins.
Maria J Redondo, Joy Jeffrey, +2 authors, Tihamer Orban.
N Engl J Med, 2008 Dec 26; 359(26). PMID: 19109586
CTLA-4 controls follicular helper T-cell differentiation by regulating the strength of CD28 engagement.
Chun Jing Wang, Frank Heuts, +7 authors, Lucy S K Walker.
Proc Natl Acad Sci U S A, 2014 Dec 31; 112(2). PMID: 25548162    Free PMC article.
Highly Cited.
PD-1 deficiency enhances humoral immunity of malaria infection treatment vaccine.
Taiping Liu, Xiao Lu, +3 authors, Wenyue Xu.
Infect Immun, 2015 Mar 04; 83(5). PMID: 25733520    Free PMC article.
Cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) regulates the unfolding of autoimmune diabetes.
F Lühder, P Höglund, +2 authors, D Mathis.
J Exp Med, 1998 Mar 21; 187(3). PMID: 9449722    Free PMC article.
Regulatory B cells: Phenotype, function and role in transplantation.
C M Wortel, S Heidt.
Transpl Immunol, 2017 Mar 05; 41. PMID: 28257995
Review.
Promiscuous gene expression in medullary thymic epithelial cells mirrors the peripheral self.
J Derbinski, A Schulte, B Kyewski, L Klein.
Nat Immunol, 2001 Oct 16; 2(11). PMID: 11600886
Highly Cited.
Tumor necrosis factor-alpha regulation of CD4+CD25+ T cell levels in NOD mice.
Ava J Wu, Hong Hua, Sibyl H Munson, Hugh O McDevitt.
Proc Natl Acad Sci U S A, 2002 Sep 11; 99(19). PMID: 12221281    Free PMC article.
Development of type 1 diabetes despite severe hereditary B-cell deficiency.
S Martin, D Wolf-Eichbaum, +4 authors, B O Roep.
N Engl J Med, 2001 Oct 06; 345(14). PMID: 11586956
Follicular helper T cell signature in type 1 diabetes.
Rupert Kenefeck, Chun Jing Wang, +11 authors, Lucy S K Walker.
J Clin Invest, 2014 Dec 09; 125(1). PMID: 25485678    Free PMC article.
Highly Cited.
PD-L1hi B cells are critical regulators of humoral immunity.
Adnan R Khan, Emily Hams, +3 authors, Padraic G Fallon.
Nat Commun, 2015 Jan 23; 6. PMID: 25609381
Highly Cited.
Updated assessment of the prevalence, spectrum and case definition of autoimmune disease.
Scott M Hayter, Matthew C Cook.
Autoimmun Rev, 2012 Mar 06; 11(10). PMID: 22387972
Review.
CD8 T cell clones from young nonobese diabetic (NOD) islets can transfer rapid onset of diabetes in NOD mice in the absence of CD4 cells.
F S Wong, I Visintin, +2 authors, C A Janeway.
J Exp Med, 1996 Jan 01; 183(1). PMID: 8551245    Free PMC article.
Highly Cited.
Screening for insulitis in adult autoantibody-positive organ donors.
Peter In't Veld, Dirk Lievens, +5 authors, Daniel Pipeleers.
Diabetes, 2007 Jun 15; 56(9). PMID: 17563060
Autoimmune syndromes in major histocompatibility complex (MHC) congenic strains of nonobese diabetic (NOD) mice. The NOD MHC is dominant for insulitis and cyclophosphamide-induced diabetes.
L S Wicker, M C Appel, +6 authors, L B Peterson.
J Exp Med, 1992 Jul 11; 176(1). PMID: 1613467    Free PMC article.
Co-stimulatory and Co-inhibitory Pathways in Autoimmunity.
Qianxia Zhang, Dario A A Vignali.
Immunity, 2016 May 19; 44(5). PMID: 27192568    Free PMC article.
Highly Cited. Review.
Prevention of experimental autoimmune encephalomyelitis by transfer of embryonic stem cell-derived dendritic cells expressing myelin oligodendrocyte glycoprotein peptide along with TRAIL or programmed death-1 ligand.
Shinya Hirata, Satoru Senju, +3 authors, Yasuharu Nishimura.
J Immunol, 2005 Feb 09; 174(4). PMID: 15699115
I-Ag7-mediated antigen presentation by B lymphocytes is critical in overcoming a checkpoint in T cell tolerance to islet beta cells of nonobese diabetic mice.
H Noorchashm, Y K Lieu, +8 authors, A Naji.
J Immunol, 1999 Jul 08; 163(2). PMID: 10395666
Cutting edge: type 1 diabetes occurs despite robust anergy among endogenous insulin-specific CD4 T cells in NOD mice.
Kristen E Pauken, Jonathan L Linehan, +7 authors, Brian T Fife.
J Immunol, 2013 Oct 15; 191(10). PMID: 24123682    Free PMC article.
Stimulating PD-1-negative signals concurrent with blocking CD154 co-stimulation induces long-term islet allograft survival.
Wenda Gao, Gülçin Demirci, Terry B Strom, Xian Chang Li.
Transplantation, 2003 Sep 26; 76(6). PMID: 14508368
CD19+CD24hiCD38hi B cells maintain regulatory T cells while limiting TH1 and TH17 differentiation.
Fabian Flores-Borja, Anneleen Bosma, +4 authors, Claudia Mauri.
Sci Transl Med, 2013 Feb 22; 5(173). PMID: 23427243
Highly Cited.
Anti-CD3 therapy promotes tolerance by selectively depleting pathogenic cells while preserving regulatory T cells.
Cristina Penaranda, Qizhi Tang, Jeffrey A Bluestone.
J Immunol, 2011 Jul 12; 187(4). PMID: 21742976    Free PMC article.
Mechanisms of central tolerance for B cells.
David Nemazee.
Nat Rev Immunol, 2017 Apr 04; 17(5). PMID: 28368006    Free PMC article.
Highly Cited. Review.
The epigenetic landscape of T cell exhaustion.
Debattama R Sen, James Kaminski, +16 authors, W Nicholas Haining.
Science, 2016 Oct 30; 354(6316). PMID: 27789799    Free PMC article.
Highly Cited.
Independent modes of natural killing distinguished in mice lacking Lag3.
T Miyazaki, A Dierich, C Benoist, D Mathis.
Science, 1996 Apr 19; 272(5260). PMID: 8602528
The AKT-mTOR axis regulates de novo differentiation of CD4+Foxp3+ cells.
Sokol Haxhinasto, Diane Mathis, Christophe Benoist.
J Exp Med, 2008 Feb 20; 205(3). PMID: 18283119    Free PMC article.
Highly Cited.
Pancreatic infiltration but not diabetes occurs in the relative absence of MHC class II-restricted CD4 T cells: studies using NOD/CIITA-deficient mice.
C Mora, F S Wong, C H Chang, R A Flavell.
J Immunol, 1999 Apr 14; 162(8). PMID: 10201997
B cells regulate autoimmunity by provision of IL-10.
Simon Fillatreau, Claire H Sweenie, +2 authors, Stephen M Anderton.
Nat Immunol, 2002 Sep 24; 3(10). PMID: 12244307
Highly Cited.
Upon TLR9 signaling, CD5+ B cells control the IL-12-dependent Th1-priming capacity of neonatal DCs.
Cheng-Ming Sun, Edith Deriaud, Claude Leclerc, Richard Lo-Man.
Immunity, 2005 Apr 23; 22(4). PMID: 15845451
T helper cell subsets in insulin-dependent diabetes.
J D Katz, C Benoist, D Mathis.
Science, 1995 May 26; 268(5214). PMID: 7761837
Highly Cited.
Functional cytotoxic T lymphocytes against IGRP206-214 predict diabetes in the non-obese diabetic mouse.
Hyun-Ja Ko, Jonathan Chee, +5 authors, Andrew M Lew.
Immunol Cell Biol, 2014 Apr 30; 92(7). PMID: 24777314
Cancer immunotherapy using checkpoint blockade.
Antoni Ribas, Jedd D Wolchok.
Science, 2018 Mar 24; 359(6382). PMID: 29567705    Free PMC article.
Highly Cited. Review.
CD154-dependent priming of diabetogenic CD4(+) T cells dissociated from activation of antigen-presenting cells.
Abdelaziz Amrani, Pau Serra, +4 authors, Pere Santamaria.
Immunity, 2002 Jun 07; 16(5). PMID: 12049723
The programmed death-1 ligand 1:B7-1 pathway restrains diabetogenic effector T cells in vivo.
Alison M Paterson, Keturah E Brown, +7 authors, Arlene H Sharpe.
J Immunol, 2011 Jun 24; 187(3). PMID: 21697456    Free PMC article.
Cutting edge: molecular analysis of the negative regulatory function of lymphocyte activation gene-3.
Creg J Workman, Kari J Dugger, Dario A A Vignali.
J Immunol, 2002 Nov 08; 169(10). PMID: 12421911
Blockade of B7-H1 and PD-1 by monoclonal antibodies potentiates cancer therapeutic immunity.
Fumiya Hirano, Katsumi Kaneko, +9 authors, Lieping Chen.
Cancer Res, 2005 Feb 12; 65(3). PMID: 15705911
Highly Cited.
Infection as a cause of type 1 diabetes?
Urs Christen, Christine Bender, Matthias G von Herrath.
Curr Opin Rheumatol, 2012 Apr 17; 24(4). PMID: 22504578    Free PMC article.
Review.
Self-Reactive B Cells in the Germinal Center Reaction.
Robert Brink, Tri Giang Phan.
Annu Rev Immunol, 2018 Jan 23; 36. PMID: 29356584
Review.
Immunogenetics of type 1 diabetes mellitus.
Michael P Morran, Andrew Vonberg, Anmar Khadra, Massimo Pietropaolo.
Mol Aspects Med, 2015 Jan 13; 42. PMID: 25579746    Free PMC article.
Review.
A defect in central tolerance in NOD mice.
H Kishimoto, J Sprent.
Nat Immunol, 2001 Oct 23; 2(11). PMID: 11668341
Aire Enforces Immune Tolerance by Directing Autoreactive T Cells into the Regulatory T Cell Lineage.
Sven Malchow, Daniel S Leventhal, +3 authors, Peter A Savage.
Immunity, 2016 May 01; 44(5). PMID: 27130899    Free PMC article.
Highly Cited.
Type 1 diabetes induction in humanized mice.
Shulian Tan, Yang Li, +12 authors, Yong-Guang Yang.
Proc Natl Acad Sci U S A, 2017 Sep 07; 114(41). PMID: 28874533    Free PMC article.
Projection of an immunological self shadow within the thymus by the aire protein.
Mark S Anderson, Emily S Venanzi, +8 authors, Diane Mathis.
Science, 2002 Oct 12; 298(5597). PMID: 12376594
Highly Cited.
Tumour- and class-specific patterns of immune-related adverse events of immune checkpoint inhibitors: a systematic review.
L Khoja, D Day, +2 authors, A R Hansen.
Ann Oncol, 2017 Sep 26; 28(10). PMID: 28945858
Highly Cited. Systematic Review.
Monoclonal antibodies specific to the glutamic acid decarboxylase 65 kDa isoform derived from a non-obese diabetic (NOD) mouse.
B Ziegler, P Augstein, +6 authors, M Ziegler.
Diabetes Res, 1994 Jan 01; 25(2). PMID: 7544254
Confusing signals: recent progress in CTLA-4 biology.
Lucy S K Walker, David M Sansom.
Trends Immunol, 2015 Jan 15; 36(2). PMID: 25582039    Free PMC article.
Highly Cited. Review.
CTLA-4 blockade increases IFNgamma-producing CD4+ICOShi cells to shift the ratio of effector to regulatory T cells in cancer patients.
Chrysoula I Liakou, Ashish Kamat, +5 authors, Padmanee Sharma.
Proc Natl Acad Sci U S A, 2008 Sep 27; 105(39). PMID: 18818309    Free PMC article.
Highly Cited.
Insulitis and β-Cell Mass in the Natural History of Type 1 Diabetes.
Martha Campbell-Thompson, Ann Fu, +4 authors, Mark A Atkinson.
Diabetes, 2015 Nov 20; 65(3). PMID: 26581594    Free PMC article.
Highly Cited.
Receptor editing is the main mechanism of B cell tolerance toward membrane antigens.
Regina Halverson, Raul M Torres, Roberta Pelanda.
Nat Immunol, 2004 May 25; 5(6). PMID: 15156139
The regulatory role of B cells in autoimmunity, infections and cancer: Perspectives beyond IL10 production.
Melisa Gorosito Serrán, Facundo Fiocca Vernengo, +3 authors, Adriana Gruppi.
FEBS Lett, 2015 Oct 02; 589(22). PMID: 26424657
Review.
Humoral autoimmunity in type 1 diabetes: prediction, significance, and detection of distinct disease subtypes.
Massimo Pietropaolo, Roberto Towns, George S Eisenbarth.
Cold Spring Harb Perspect Med, 2012 Oct 03; 2(10). PMID: 23028135    Free PMC article.
Review.
Anti-DNA antibodies form immune deposits at distinct glomerular and vascular sites.
D V Vlahakos, M H Foster, +5 authors, M P Madaio.
Kidney Int, 1992 Jun 01; 41(6). PMID: 1501424
PD-1 regulates germinal center B cell survival and the formation and affinity of long-lived plasma cells.
Kim L Good-Jacobson, Courtney G Szumilas, +3 authors, Mark J Shlomchik.
Nat Immunol, 2010 May 11; 11(6). PMID: 20453843    Free PMC article.
Highly Cited.
Absence of autoantibodies against glutamate decarboxylase (GAD) in the non-obese diabetic (NOD) mouse and low expression of the enzyme in mouse islets.
L A Velloso, D L Eizirik, F A Karlsson, O Kämpe.
Clin Exp Immunol, 1994 Apr 01; 96(1). PMID: 8149657    Free PMC article.
CD8+ T cells specific for the islet autoantigen IGRP are restricted in their T cell receptor chain usage.
Yannick F Fuchs, Anne Eugster, +9 authors, Ezio Bonifacio.
Sci Rep, 2017 Mar 17; 7. PMID: 28300170    Free PMC article.
CTLA-4 blockade reverses CD8+ T cell tolerance to tumor by a CD4+ T cell- and IL-2-dependent mechanism.
P Shrikant, A Khoruts, M F Mescher.
Immunity, 1999 Nov 05; 11(4). PMID: 10549630
The NOD mouse: a model of immune dysregulation.
Mark S Anderson, Jeffrey A Bluestone.
Annu Rev Immunol, 2005 Mar 18; 23. PMID: 15771578
Highly Cited. Review.
Role of ICOS pathway in autoimmune and alloimmune responses in NOD mice.
Mohammed Javeed I Ansari, Paolo Fiorina, +7 authors, Mohamed H Sayegh.
Clin Immunol, 2007 Sep 25; 126(2). PMID: 17889619
Anti-islet autoantibodies trigger autoimmune diabetes in the presence of an increased frequency of islet-reactive CD4 T cells.
Diego G Silva, Stephen R Daley, +6 authors, Carola G Vinuesa.
Diabetes, 2011 Jul 27; 60(8). PMID: 21788582    Free PMC article.
Asymmetric thymocyte death underlies the CD4:CD8 T-cell ratio in the adaptive immune system.
Charles Sinclair, Iren Bains, Andrew J Yates, Benedict Seddon.
Proc Natl Acad Sci U S A, 2013 Jul 17; 110(31). PMID: 23858460    Free PMC article.
A functional variant of lymphoid tyrosine phosphatase is associated with type I diabetes.
Nunzio Bottini, Lucia Musumeci, +10 authors, Tomas Mustelin.
Nat Genet, 2004 Mar 09; 36(4). PMID: 15004560
Highly Cited.
In vivo blockade of CTLA-4 enhances the priming of responsive T cells but fails to prevent the induction of tumor antigen-specific tolerance.
E M Sotomayor, I Borrello, +2 authors, H I Levitsky.
Proc Natl Acad Sci U S A, 1999 Sep 29; 96(20). PMID: 10500201    Free PMC article.
Islet-specific CTL cloned from a type 1 diabetes patient cause beta-cell destruction after engraftment into HLA-A2 transgenic NOD/scid/IL2RG null mice.
Wendy W J Unger, Todd Pearson, +10 authors, Bart O Roep.
PLoS One, 2012 Nov 17; 7(11). PMID: 23155466    Free PMC article.
Enhanced thymic selection of FoxP3+ regulatory T cells in the NOD mouse model of autoimmune diabetes.
Markus Feuerer, Wenyu Jiang, +5 authors, Christophe Benoist.
Proc Natl Acad Sci U S A, 2007 Nov 10; 104(46). PMID: 17991775    Free PMC article.
Induction of peripheral T cell tolerance in vivo requires CTLA-4 engagement.
V L Perez, L Van Parijs, +3 authors, A K Abbas.
Immunity, 1997 Apr 01; 6(4). PMID: 9133420
Highly Cited.
Co-stimulation modulation with abatacept in patients with recent-onset type 1 diabetes: a randomised, double-blind, placebo-controlled trial.
Tihamer Orban, Brian Bundy, +17 authors, Type 1 Diabetes TrialNet Abatacept Study Group.
Lancet, 2011 Jul 02; 378(9789). PMID: 21719096    Free PMC article.
Highly Cited.
Type 1 diabetes is associated with enterovirus infection in gut mucosa.
Maarit Oikarinen, Sisko Tauriainen, +6 authors, Heikki Hyöty.
Diabetes, 2012 Feb 09; 61(3). PMID: 22315304    Free PMC article.
The diverse functions of the PD1 inhibitory pathway.
Arlene H Sharpe, Kristen E Pauken.
Nat Rev Immunol, 2017 Oct 11; 18(3). PMID: 28990585
Highly Cited. Review.
Negative regulation of T cell homeostasis by lymphocyte activation gene-3 (CD223).
Creg J Workman, Dario A A Vignali.
J Immunol, 2005 Jan 07; 174(2). PMID: 15634887
T Cell-Mediated Beta Cell Destruction: Autoimmunity and Alloimmunity in the Context of Type 1 Diabetes.
Adam L Burrack, Tijana Martinov, Brian T Fife.
Front Endocrinol (Lausanne), 2017 Dec 21; 8. PMID: 29259578    Free PMC article.
Review.
The CD4-related molecule, LAG-3 (CD223), regulates the expansion of activated T cells.
Creg J Workman, Dario A A Vignali.
Eur J Immunol, 2003 Apr 03; 33(4). PMID: 12672063
Thymus-specific deletion of insulin induces autoimmune diabetes.
Yong Fan, William A Rudert, +3 authors, Massimo Trucco.
EMBO J, 2009 Aug 15; 28(18). PMID: 19680229    Free PMC article.
Interleukin-10 Producing Regulatory B Cells Transformed CD4+CD25- Into Tregs and Enhanced Regulatory T Cells Function in Human Leprosy.
Mohd Tarique, Huma Naz, +7 authors, Alpana Sharma.
Front Immunol, 2018 Aug 08; 9. PMID: 30083152    Free PMC article.
Phenotypic analysis of the murine CD4-related glycoprotein, CD223 (LAG-3).
Creg J Workman, Dennis S Rice, +2 authors, Dario A A Vignali.
Eur J Immunol, 2002 Sep 05; 32(8). PMID: 12209638
Tolerance through indifference: autoreactive B cells to the nuclear antigen La show no evidence of tolerance in a transgenic model.
Brett D Aplin, Catherine L Keech, +3 authors, James McCluskey.
J Immunol, 2003 Nov 25; 171(11). PMID: 14634099
HLA DR-DQ haplotypes and genotypes and type 1 diabetes risk: analysis of the type 1 diabetes genetics consortium families.
Henry Erlich, Ana Maria Valdes, +11 authors, Type 1 Diabetes Genetics Consortium.
Diabetes, 2008 Feb 07; 57(4). PMID: 18252895    Free PMC article.
Highly Cited.
A polymorphic locus near the human insulin gene is associated with insulin-dependent diabetes mellitus.
G I Bell, S Horita, J H Karam.
Diabetes, 1984 Feb 01; 33(2). PMID: 6363172
Highly Cited.
PD-1/PD-L1 costimulatory pathway-induced mouse islet transplantation immune tolerance.
T Li, R Ma, +3 authors, X S Leng.
Transplant Proc, 2015 Feb 04; 47(1). PMID: 25645798
Receptor editing: an approach by autoreactive B cells to escape tolerance.
D Gay, T Saunders, S Camper, M Weigert.
J Exp Med, 1993 Apr 01; 177(4). PMID: 8459227    Free PMC article.
Highly Cited.
Fibrinogen-like Protein 1 Is a Major Immune Inhibitory Ligand of LAG-3.
Jun Wang, Miguel F Sanmamed, +18 authors, Lieping Chen.
Cell, 2018 Dec 26; 176(1-2). PMID: 30580966    Free PMC article.
Highly Cited.
Prolonged antigen presentation by immune complex-binding dendritic cells programs the proliferative capacity of memory CD8 T cells.
Beatriz León, André Ballesteros-Tato, Troy D Randall, Frances E Lund.
J Exp Med, 2014 Jul 09; 211(8). PMID: 25002751    Free PMC article.
Insulin-induced remission in new-onset NOD mice is maintained by the PD-1-PD-L1 pathway.
Brian T Fife, Indira Guleria, +7 authors, Jeffrey A Bluestone.
J Exp Med, 2006 Nov 23; 203(12). PMID: 17116737    Free PMC article.
Highly Cited.
Lymphocyte Activation Gene 3 (LAG-3) modulates the ability of CD4 T-cells to be suppressed in vivo.
Nicholas M Durham, Christopher J Nirschl, +4 authors, Charles G Drake.
PLoS One, 2014 Nov 06; 9(11). PMID: 25372844    Free PMC article.
Antibody effector functions mediated by Fcγ-receptors are compromised during persistent viral infection.
Andreas Wieland, Rangaiah Shashidharamurthy, +9 authors, Rafi Ahmed.
Immunity, 2015 Feb 15; 42(2). PMID: 25680276    Free PMC article.
Enhancement of antitumor immunity by CTLA-4 blockade.
D R Leach, M F Krummel, J P Allison.
Science, 1996 Mar 22; 271(5256). PMID: 8596936
Highly Cited.
Genetic evidence that the differential expression of the ligand-independent isoform of CTLA-4 is the molecular basis of the Idd5.1 type 1 diabetes region in nonobese diabetic mice.
Manabu Araki, Denise Chung, +11 authors, Linda S Wicker.
J Immunol, 2009 Sep 29; 183(8). PMID: 19783679    Free PMC article.
Molecular and transcriptional basis of CD4⁺ T cell dysfunction during chronic infection.
Alison Crawford, Jill M Angelosanto, +4 authors, E John Wherry.
Immunity, 2014 Feb 18; 40(2). PMID: 24530057    Free PMC article.
Highly Cited.
Lipopolysaccharide-activated B cells down-regulate Th1 immunity and prevent autoimmune diabetes in nonobese diabetic mice.
J Tian, D Zekzer, +3 authors, D L Kaufman.
J Immunol, 2001 Jul 07; 167(2). PMID: 11441119
Highly Cited.
Aspartate at position 57 of nonobese diabetic I-Ag7 beta-chain diminishes the spontaneous incidence of insulin-dependent diabetes mellitus.
R Quartey-Papafio, T Lund, +7 authors, E Simpson.
J Immunol, 1995 May 15; 154(10). PMID: 7730655
Mechanisms of Regulatory B cell Function in Autoimmune and Inflammatory Diseases beyond IL-10.
Avijit Ray, Bonnie N Dittel.
J Clin Med, 2017 Jan 27; 6(1). PMID: 28124981    Free PMC article.
Review.
BCG-Induced Cross-Protection and Development of Trained Immunity: Implication for Vaccine Design.
Camila Covián, Ayleen Fernández-Fierro, +7 authors, Alexis M Kalergis.
Front Immunol, 2019 Dec 19; 10. PMID: 31849980    Free PMC article.
Highly Cited. Review.
Pancreatic β-cells in type 1 and type 2 diabetes mellitus: different pathways to failure.
Décio L Eizirik, Lorenzo Pasquali, Miriam Cnop.
Nat Rev Endocrinol, 2020 May 14; 16(7). PMID: 32398822
Review.
From Mesenchymal Stromal/Stem Cells to Insulin-Producing Cells: Immunological Considerations.
Ayman F Refaie, Batoul L Elbassiouny, +5 authors, Mohamed A Ghoneim.
Front Immunol, 2021 Jul 13; 12. PMID: 34248981    Free PMC article.
Review.
The Role of Programmed Death-1 in Type 1 Diabetes.
Christopher G Tucker, Alexander J Dwyer, Brian T Fife, Tijana Martinov.
Curr Diab Rep, 2021 May 07; 21(6). PMID: 33956235    Free PMC article.
Review.
From Pancreatic β-Cell Gene Networks to Novel Therapies for Type 1 Diabetes.
Decio L Eizirik, Florian Szymczak, Maria Inês Alvelos, Frank Martin.
Diabetes, 2021 Aug 22; 70(9). PMID: 34417266    Free PMC article.
Review.