Combination immunotherapy of B16 melanoma using anti-cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) and granulocyte/macrophage colony-stimulating factor (GM-CSF)-producing vaccines induces rejection of subcutaneous and metastatic tumors accompanied by autoimmune depigmentation. A van Elsas, A A Hurwitz, J P Allison. J Exp Med, 1999 Aug 03; 190(3). PMID: 10430624 Free PMC article. Highly Cited.
|
Synergism of cytotoxic T lymphocyte-associated antigen 4 blockade and depletion of CD25(+) regulatory T cells in antitumor therapy reveals alternative pathways for suppression of autoreactive cytotoxic T lymphocyte responses. R P Sutmuller, L M van Duivenvoorde, +6 authors, A van Elsas, T N Schumacher, M E Wildenberg, J P Allison, R E Toes, R Offringa, C J Melief. less J Exp Med, 2001 Sep 19; 194(6). PMID: 11560997 Free PMC article. Highly Cited.
|
Differential contribution of Toll-like receptors 4 and 2 to the cytokine response to Salmonella enterica serovar Typhimurium and Staphylococcus aureus in mice. Annalisa Lembo, Christoph Kalis, +5 authors, Carsten J Kirschning, Vincenzo Mitolo, Emilio Jirillo, Hermann Wagner, Chris Galanos, Marina A Freudenberg. less Infect Immun, 2003 Sep 23; 71(10). PMID: 14500530 Free PMC article.
|
Toll-like receptor 5 recognizes a conserved site on flagellin required for protofilament formation and bacterial motility. Kelly D Smith, Erica Andersen-Nissen, +5 authors, Fumitaka Hayashi, Katie Strobe, Molly A Bergman, Sara L Rassoulian Barrett, Brad T Cookson, Alan Aderem. less Nat Immunol, 2003 Nov 20; 4(12). PMID: 14625549 Highly Cited.
|
Tumour suppression induced by the macrophage activating lipopeptide MALP-2 in an ultrasound guided pancreatic carcinoma mouse model. C Schneider, T Schmidt, +9 authors, C Ziske, K Tiemann, K-M Lee, V Uhlinsky, P Behrens, T Sauerbruch, I G H Schmidt-Wolf, P F Mühlradt, J Schmidt, A Märten. less Gut, 2004 Feb 13; 53(3). PMID: 14960515 Free PMC article.
|
TLR2 is expressed on activated T cells as a costimulatory receptor. Mousa Komai-Koma, Louise Jones, +2 authors, Graham S Ogg, Damo Xu, Foo Y Liew. less Proc Natl Acad Sci U S A, 2004 Feb 26; 101(9). PMID: 14981245 Free PMC article. Highly Cited.
|
Toll-like receptor 4 dependence of innate and adaptive immunity to Salmonella: importance of the Kupffer cell network. Andrés Vazquez-Torres, Bruce A Vallance, +4 authors, Molly A Bergman, B Brett Finlay, Brad T Cookson, Jessica Jones-Carson, Ferric C Fang. less J Immunol, 2004 May 07; 172(10). PMID: 15128808
|
Targeted expression of Cre recombinase in macrophages and osteoclasts in transgenic mice. M Ferron, J Vacher. Genesis, 2005 Mar 09; 41(3). PMID: 15754380
|
Direct stimulation of human T cells via TLR5 and TLR7/8: flagellin and R-848 up-regulate proliferation and IFN-gamma production by memory CD4+ T cells. Gersende Caron, Dorothée Duluc, +4 authors, Isabelle Frémaux, Pascale Jeannin, Catherine David, Hugues Gascan, Yves Delneste. less J Immunol, 2005 Jul 22; 175(3). PMID: 16034093 Highly Cited.
|
The TLR-7 agonist, imiquimod, enhances dendritic cell survival and promotes tumor antigen-specific T cell priming: relation to central nervous system antitumor immunity. Robert M Prins, Noah Craft, +5 authors, Kevin W Bruhn, Haumith Khan-Farooqi, Richard C Koya, Renata Stripecke, Jeff F Miller, Linda M Liau. less J Immunol, 2005 Dec 21; 176(1). PMID: 16365406
|
Toll-like receptor 2 signaling modulates the functions of CD4+ CD25+ regulatory T cells. Haiying Liu, Mousa Komai-Koma, Damo Xu, Foo Y Liew. Proc Natl Acad Sci U S A, 2006 Apr 25; 103(18). PMID: 16632602 Free PMC article. Highly Cited.
|
TLR2 engagement on CD8 T cells lowers the threshold for optimal antigen-induced T cell activation. Anne Cottalorda, Claire Verschelde, +6 authors, Antoine Marçais, Martine Tomkowiak, Philippe Musette, Satoshi Uematsu, Shizuo Akira, Jacqueline Marvel, Nathalie Bonnefoy-Berard. less Eur J Immunol, 2006 Jun 09; 36(7). PMID: 16761317
|
CTLA4 blockade and GM-CSF combination immunotherapy alters the intratumor balance of effector and regulatory T cells. Sergio A Quezada, Karl S Peggs, Michael A Curran, James P Allison. J Clin Invest, 2006 Jun 17; 116(7). PMID: 16778987 Free PMC article. Highly Cited.
|
Development of TLR9 agonists for cancer therapy. Arthur M Krieg. J Clin Invest, 2007 May 04; 117(5). PMID: 17476348 Free PMC article. Highly Cited. Review.
|
CD4+CD25+Foxp3+ regulatory T cells induce alternative activation of human monocytes/macrophages. Machteld M Tiemessen, Ann L Jagger, +3 authors, Hayley G Evans, Martijn J C van Herwijnen, Susan John, Leonie S Taams. less Proc Natl Acad Sci U S A, 2007 Nov 29; 104(49). PMID: 18042719 Free PMC article. Highly Cited.
|
Engagement of Toll-like receptor-2 on cytotoxic T-lymphocytes occurs in vivo and augments antitumor activity. Nicole Asprodites, Liqin Zheng, +3 authors, Degui Geng, Cruz Velasco-Gonzalez, Luis Sanchez-Perez, Eduardo Davila. less FASEB J, 2008 Jul 01; 22(10). PMID: 18587008 Free PMC article.
|
HMGB1 mediates endogenous TLR2 activation and brain tumor regression. James F Curtin, Naiyou Liu, +14 authors, Marianela Candolfi, Weidong Xiong, Hikmat Assi, Kader Yagiz, Matthew R Edwards, Kathrin S Michelsen, Kurt M Kroeger, Chunyan Liu, A K M Ghulam Muhammad, Mary C Clark, Moshe Arditi, Begonya Comin-Anduix, Antoni Ribas, Pedro R Lowenstein, Maria G Castro. less PLoS Med, 2009 Jan 16; 6(1). PMID: 19143470 Free PMC article. Highly Cited.
|
Blockade of CTLA-4 on both effector and regulatory T cell compartments contributes to the antitumor activity of anti-CTLA-4 antibodies. Karl S Peggs, Sergio A Quezada, +2 authors, Cynthia A Chambers, Alan J Korman, James P Allison. less J Exp Med, 2009 Jul 08; 206(8). PMID: 19581407 Free PMC article. Highly Cited.
|
TLR4- and TLR2-mediated B cell responses control the clearance of the bacterial pathogen, Leptospira interrogans. Cécilia Chassin, Mathieu Picardeau, +10 authors, Jean-Michel Goujon, Pascale Bourhy, Nathalie Quellard, Sylvie Darche, Edgar Badell, Martine Fanton d'Andon, Nathalie Winter, Sonia Lacroix-Lamandé, Dominique Buzoni-Gatel, Alain Vandewalle, Catherine Werts. less J Immunol, 2009 Jul 29; 183(4). PMID: 19635914
|
PD-1 and CTLA-4 combination blockade expands infiltrating T cells and reduces regulatory T and myeloid cells within B16 melanoma tumors. Michael A Curran, Welby Montalvo, Hideo Yagita, James P Allison. Proc Natl Acad Sci U S A, 2010 Feb 18; 107(9). PMID: 20160101 Free PMC article. Highly Cited.
|
Improved survival with ipilimumab in patients with metastatic melanoma. F Stephen Hodi, Steven J O'Day, +26 authors, David F McDermott, Robert W Weber, Jeffrey A Sosman, John B Haanen, Rene Gonzalez, Caroline Robert, Dirk Schadendorf, Jessica C Hassel, Wallace Akerley, Alfons J M van den Eertwegh, Jose Lutzky, Paul Lorigan, Julia M Vaubel, Gerald P Linette, David Hogg, Christian H Ottensmeier, Celeste Lebbé, Christian Peschel, Ian Quirt, Joseph I Clark, Jedd D Wolchok, Jeffrey S Weber, Jason Tian, Michael J Yellin, Geoffrey M Nichol, Axel Hoos, Walter J Urba. less N Engl J Med, 2010 Jun 08; 363(8). PMID: 20525992 Free PMC article. Highly Cited.
|
Amplifying TLR-MyD88 signals within tumor-specific T cells enhances antitumor activity to suboptimal levels of weakly immunogenic tumor antigens. Degui Geng, Liqin Zheng, +4 authors, Ratika Srivastava, Cruz Velasco-Gonzalez, Adam Riker, Svetomir N Markovic, Eduardo Davila. less Cancer Res, 2010 Sep 03; 70(19). PMID: 20807806 Free PMC article.
|
A critical role for mast cells and mast cell-derived IL-6 in TLR2-mediated inhibition of tumor growth. Sharon A Oldford, Ian D Haidl, +3 authors, Mackenzie A Howatt, Carlos A Leiva, Brent Johnston, Jean S Marshall. less J Immunol, 2010 Nov 03; 185(11). PMID: 21041732
|
Engagement of TLR2 reverses the suppressor function of conjunctiva CD4+CD25+ regulatory T cells and promotes herpes simplex virus epitope-specific CD4+CD25- effector T cell responses. Gargi Dasgupta, Aziz Alami Chentoufi, +7 authors, Sylvaine You, Payam Falatoonzadeh, Lourie Ann A Urbano, Ayesha Akhtarmalik, Kimberly Nguyen, Lilit Ablabutyan, Anthony B Nesburn, Lbachir BenMohamed. less Invest Ophthalmol Vis Sci, 2011 Jan 29; 52(6). PMID: 21273544 Free PMC article.
|
TLR2 agonist PSK activates human NK cells and enhances the antitumor effect of HER2-targeted monoclonal antibody therapy. Hailing Lu, Yi Yang, +4 authors, Ekram Gad, Carol Inatsuka, Cynthia A Wenner, Mary L Disis, Leanna J Standish. less Clin Cancer Res, 2011 Sep 16; 17(21). PMID: 21918170 Free PMC article.
|
Protective and pathogenic functions of macrophage subsets. Peter J Murray, Thomas A Wynn. Nat Rev Immunol, 2011 Oct 15; 11(11). PMID: 21997792 Free PMC article. Highly Cited. Review.
|
Potent induction of tumor immunity by combining tumor cryoablation with anti-CTLA-4 therapy. Rebecca Waitz, Stephen B Solomon, +4 authors, Elena N Petre, Anne E Trumble, Marcella Fassò, Larry Norton, James P Allison. less Cancer Res, 2011 Nov 24; 72(2). PMID: 22108823 Free PMC article.
|
Intratumoral injection of CpG oligonucleotides induces the differentiation and reduces the immunosuppressive activity of myeloid-derived suppressor cells. Yuko Shirota, Hidekazu Shirota, Dennis M Klinman. J Immunol, 2012 Jan 11; 188(4). PMID: 22231700 Free PMC article. Highly Cited.
|
Toll-like receptor 7 agonist therapy with imidazoquinoline enhances cancer cell death and increases lymphocytic infiltration and proinflammatory cytokine production in established tumors of a renal cell carcinoma mouse model. Eric C Kauffman, Huixian Liu, Michael J Schwartz, Douglas S Scherr. J Oncol, 2012 Apr 07; 2012. PMID: 22481916 Free PMC article.
|
Synergy of topical toll-like receptor 7 agonist with radiation and low-dose cyclophosphamide in a mouse model of cutaneous breast cancer. M Zahidunnabi Dewan, Claire Vanpouille-Box, +5 authors, Noriko Kawashima, Sara DiNapoli, James S Babb, Silvia C Formenti, Sylvia Adams, Sandra Demaria. less Clin Cancer Res, 2012 Oct 11; 18(24). PMID: 23048078 Free PMC article.
|
Systemic delivery of a TLR7 agonist in combination with radiation primes durable antitumor immune responses in mouse models of lymphoma. Simon J Dovedi, Monique H M Melis, +4 authors, Robert W Wilkinson, Amy L Adlard, Ian J Stratford, Jamie Honeychurch, Timothy M Illidge. less Blood, 2012 Oct 23; 121(2). PMID: 23086756
|
Sphingosine-1-phosphate suppresses TLR-induced CXCL8 secretion from human T cells. Naveen Sharma, Ajay Suresh Akhade, Ayub Qadri. J Leukoc Biol, 2013 Jan 25; 93(4). PMID: 23345392
|
Nivolumab plus ipilimumab in advanced melanoma. Jedd D Wolchok, Harriet Kluger, +21 authors, Margaret K Callahan, Michael A Postow, Naiyer A Rizvi, Alexander M Lesokhin, Neil H Segal, Charlotte E Ariyan, Ruth-Ann Gordon, Kathleen Reed, Matthew M Burke, Anne Caldwell, Stephanie A Kronenberg, Blessing U Agunwamba, Xiaoling Zhang, Israel Lowy, Hector David Inzunza, William Feely, Christine E Horak, Quan Hong, Alan J Korman, Jon M Wigginton, Ashok Gupta, Mario Sznol. less N Engl J Med, 2013 Jun 04; 369(2). PMID: 23724867 Free PMC article. Highly Cited.
|
Depleting tumor-specific Tregs at a single site eradicates disseminated tumors. Aurélien Marabelle, Holbrook Kohrt, +13 authors, Idit Sagiv-Barfi, Bahareh Ajami, Robert C Axtell, Gang Zhou, Ranjani Rajapaksa, Michael R Green, James Torchia, Joshua Brody, Richard Luong, Michael D Rosenblum, Lawrence Steinman, Hyam I Levitsky, Victor Tse, Ronald Levy. less J Clin Invest, 2013 Jun 04; 123(6). PMID: 23728179 Free PMC article. Highly Cited.
|
Inflammatory monocytes are potent antitumor effectors controlled by regulatory CD4+ T cells. Arnaud Pommier, Alexandra Audemard, +10 authors, Aurélie Durand, Renée Lengagne, Arnaud Delpoux, Bruno Martin, Laetitia Douguet, Armelle Le Campion, Masashi Kato, Marie-Françoise Avril, Cédric Auffray, Bruno Lucas, Armelle Prévost-Blondel. less Proc Natl Acad Sci U S A, 2013 Jul 24; 110(32). PMID: 23878221 Free PMC article.
|
Fc-dependent depletion of tumor-infiltrating regulatory T cells co-defines the efficacy of anti-CTLA-4 therapy against melanoma. Tyler R Simpson, Fubin Li, +11 authors, Welby Montalvo-Ortiz, Manuel A Sepulveda, Katharina Bergerhoff, Frederick Arce, Claire Roddie, Jake Y Henry, Hideo Yagita, Jedd D Wolchok, Karl S Peggs, Jeffrey V Ravetch, James P Allison, Sergio A Quezada. less J Exp Med, 2013 Jul 31; 210(9). PMID: 23897981 Free PMC article. Highly Cited.
|
Activating Fc γ receptors contribute to the antitumor activities of immunoregulatory receptor-targeting antibodies. Yannick Bulliard, Rose Jolicoeur, +6 authors, Maurice Windman, Sarah M Rue, Seth Ettenberg, Deborah A Knee, Nicholas S Wilson, Glenn Dranoff, Jennifer L Brogdon. less J Exp Med, 2013 Jul 31; 210(9). PMID: 23897982 Free PMC article. Highly Cited.
|
TLR-mediated activation of NK cells and their role in bacterial/viral immune responses in mammals. Minou Adib-Conquy, Daniel Scott-Algara, Jean-Marc Cavaillon, Fernando Souza-Fonseca-Guimaraes. Immunol Cell Biol, 2013 Dec 25; 92(3). PMID: 24366517 Highly Cited. Review.
|
Engagement of the ICOS pathway markedly enhances efficacy of CTLA-4 blockade in cancer immunotherapy. Xiaozhou Fan, Sergio A Quezada, +2 authors, Manuel A Sepulveda, Padmanee Sharma, James P Allison. less J Exp Med, 2014 Apr 02; 211(4). PMID: 24687957 Free PMC article. Highly Cited.
|
Anti-CTLA-4 antibodies of IgG2a isotype enhance antitumor activity through reduction of intratumoral regulatory T cells. Mark J Selby, John J Engelhardt, +4 authors, Michael Quigley, Karla A Henning, Timothy Chen, Mohan Srinivasan, Alan J Korman. less Cancer Immunol Res, 2014 Apr 30; 1(1). PMID: 24777248 Highly Cited.
|
Impact of tumour microenvironment and Fc receptors on the activity of immunomodulatory antibodies. Andrew J S Furness, Frederick Arce Vargas, Karl S Peggs, Sergio A Quezada. Trends Immunol, 2014 Jun 24; 35(7). PMID: 24953012 Review.
|
Organoid models of human and mouse ductal pancreatic cancer. Sylvia F Boj, Chang-Il Hwang, +45 authors, Lindsey A Baker, Iok In Christine Chio, Dannielle D Engle, Vincenzo Corbo, Myrthe Jager, Mariano Ponz-Sarvise, Hervé Tiriac, Mona S Spector, Ana Gracanin, Tobiloba Oni, Kenneth H Yu, Ruben van Boxtel, Meritxell Huch, Keith D Rivera, John P Wilson, Michael E Feigin, Daniel Öhlund, Abram Handly-Santana, Christine M Ardito-Abraham, Michael Ludwig, Ela Elyada, Brinda Alagesan, Giulia Biffi, Georgi N Yordanov, Bethany Delcuze, Brianna Creighton, Kevin Wright, Youngkyu Park, Folkert H M Morsink, I Quintus Molenaar, Inne H Borel Rinkes, Edwin Cuppen, Yuan Hao, Ying Jin, Isaac J Nijman, Christine Iacobuzio-Donahue, Steven D Leach, Darryl J Pappin, Molly Hammell, David S Klimstra, Olca Basturk, Ralph H Hruban, George Johan Offerhaus, Robert G J Vries, Hans Clevers, David A Tuveson. less Cell, 2015 Jan 06; 160(1-2). PMID: 25557080 Free PMC article. Highly Cited.
|
TLR2/6 agonists and interferon-gamma induce human melanoma cells to produce CXCL10. Ileana S Mauldin, Ena Wang, +3 authors, Donna H Deacon, Walter C Olson, Yongde Bao, Craig L Slingluff. less Int J Cancer, 2015 Mar 15; 137(6). PMID: 25765738 Free PMC article.
|
Immune checkpoint targeting in cancer therapy: toward combination strategies with curative potential. Padmanee Sharma, James P Allison. Cell, 2015 Apr 11; 161(2). PMID: 25860605 Free PMC article. Highly Cited. Review.
|
Ipilimumab-dependent cell-mediated cytotoxicity of regulatory T cells ex vivo by nonclassical monocytes in melanoma patients. Emanuela Romano, Monika Kusio-Kobialka, +7 authors, Periklis G Foukas, Petra Baumgaertner, Christiane Meyer, Pierluigi Ballabeni, Olivier Michielin, Benjamin Weide, Pedro Romero, Daniel E Speiser. less Proc Natl Acad Sci U S A, 2015 Apr 29; 112(19). PMID: 25918390 Free PMC article. Highly Cited.
|
Intratumoral immunotherapy for melanoma. Manisha Singh, Willem W Overwijk. Cancer Immunol Immunother, 2015 Jun 08; 64(7). PMID: 26050024 Review.
|
FcγRs Modulate the Anti-tumor Activity of Antibodies Targeting the PD-1/PD-L1 Axis. Rony Dahan, Emanuela Sega, +3 authors, John Engelhardt, Mark Selby, Alan J Korman, Jeffrey V Ravetch. less Cancer Cell, 2015 Sep 17; 28(3). PMID: 26373277 Highly Cited.
|
Cross-talk between pathogen recognizing Toll-like receptors and immunoglobulin Fc receptors in immunity. Marjolein van Egmond, Gestur Vidarsson, Jantine E Bakema. Immunol Rev, 2015 Oct 27; 268(1). PMID: 26497530 Review.
|
Toll-like Receptor 2 Activation Promotes Tumor Dendritic Cell Dysfunction by Regulating IL-6 and IL-10 Receptor Signaling. Michael Tang, Jun Diao, +3 authors, Hongtao Gu, Ismat Khatri, Jun Zhao, Mark S Cattral. less Cell Rep, 2015 Dec 30; 13(12). PMID: 26711349
|
Trial Watch: Immunostimulation with Toll-like receptor agonists in cancer therapy. Kristina Iribarren, Norma Bloy, +9 authors, Aitziber Buqué, Isabelle Cremer, Alexander Eggermont, Wolf Hervé Fridman, Jitka Fucikova, Jérôme Galon, Radek Špíšek, Laurence Zitvogel, Guido Kroemer, Lorenzo Galluzzi. less Oncoimmunology, 2016 May 04; 5(3). PMID: 27141345 Free PMC article. Highly Cited. Review.
|
Fc Effector Function Contributes to the Activity of Human Anti-CTLA-4 Antibodies. Frederick Arce Vargas, Andrew J S Furness, +32 authors, Kevin Litchfield, Kroopa Joshi, Rachel Rosenthal, Ehsan Ghorani, Isabelle Solomon, Marta H Lesko, Nora Ruef, Claire Roddie, Jake Y Henry, Lavinia Spain, Assma Ben Aissa, Andrew Georgiou, Yien Ning Sophia Wong, Myles Smith, Dirk Strauss, Andrew Hayes, David Nicol, Tim O'Brien, Linda Mårtensson, Anne Ljungars, Ingrid Teige, Björn Frendéus, TRACERx Melanoma, TRACERx Renal, TRACERx Lung consortia, Martin Pule, Teresa Marafioti, Martin Gore, James Larkin, Samra Turajlic, Charles Swanton, Karl S Peggs, Sergio A Quezada. less Cancer Cell, 2018 Mar 27; 33(4). PMID: 29576375 Free PMC article. Highly Cited.
|
Anti-CTLA-4 Immunotherapy Does Not Deplete FOXP3+ Regulatory T Cells (Tregs) in Human Cancers. Anu Sharma, Sumit K Subudhi, +6 authors, Jorge Blando, Jorge Scutti, Luis Vence, Jennifer Wargo, James P Allison, Antoni Ribas, Padmanee Sharma. less Clin Cancer Res, 2018 Jul 29; 25(4). PMID: 30054281 Free PMC article. Highly Cited.
|
Enhancement of antitumor immunity by CTLA-4 blockade. D R Leach, M F Krummel, J P Allison. Science, 1996 Mar 22; 271(5256). PMID: 8596936 Highly Cited.
|